i2b2 clinical datawarehouse at the pompidou university hospital in paris … · 2014. 5. 27. ·...
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i2b2 Clinical Datawarehouse at the Pompidou University Hospital
in Paris (APHP - HEGP)
Paul Avillach, MD, PhD
Hôpital Européen Georges Pompidou (HEGP) Faculté de Médecine René Descartes, Université Paris 5
INSERM UMR_S 872 eq22
CBMI – Harvard Medical School
ErasmusMC University
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Location • Paris 15th district
Within AP-HP • HEGP is the most recent acute care hospital within the 38 AP-HP hospitals
• HEGP meets the needs of the 600, 000 inhabitants of the Paris south-west
HEGP Background
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HEGP background
Hôpital Laennec (1634) Hôpital Boucicaut Hôpital Broussais
Opening : July 2000-
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HEGP BDW HER/CDW integration
EHR :
Operational Database
(ODS)
EHR :
Mirrored Database
Production environment Evaluation/Research environment
ETL suite (Talend Open Studio)
Clinical Data Warehouse
(CDW)
External Databases
Data Analysis Data Mining
R i2b2/tranSMART tools Business Object IBM Ilog Rules
Real time requests
CIO: Pr Patrice Degoulet Pr Anita Burgun
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PI: Isaac Kohane – Harvard - CBMI
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HEGP i2b2
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HEGP CDW
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CDW use
• 188 MD + Pharm trained
• IRB Creation of an HEGP research ethical committee linked to the regional IRB
i2b2 CDW queries (Jan. 2011-Dec 2013)
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HEGP CDW
• Level 1 studies : aggregated data (e.g. potential trial recruitment) Ø Free access for all HEGP health professionals Ø 2 209 requests
• Level 2 and 3 studies : access to patient level data Ø Structured written project Ø Validation by the HEGP IRB Ø Transmission to the regional IRB Ø Level 2 : anonymized patient data Ø Level 3 : de-anonymized patient data
Ø IRB approval for 35 projects
i2b2 CDW use (Jan. 2011-Dec. 2013)
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PheWAS study on i2b2
Datatypes:
• ICD10 • Drug prescription
• Lab results
• Clinical Notes
Time points+++
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Phenotype
Thiopurine dose
Low activity
Intermediate activity
Normal Activity
10 % dose
30 – 70 % dose
100 % dose
FDA & EMA recommendations
?
Methodes: Selection of trait:
enzymatic Activity TPMT
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TPMT
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ICD10
Very High TPMT activity VS others
256 ICD-10 based aggregated
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Acknowledgments
Informatics & Public Health Dept : • Eric Zapletal, • Antoine Neuraz, • Anita Burgun, • Patrice Degoulet
www.i2b2.org