ISSN 0036-807529 OCTOBER 1993VOLUME 262NUMBER 5134

AMERICANASSOCIATION FOR THEADVANCEMENT OFSCIENCE

NEWS & COMMENT MW&

Is There Life After the SSC?

New Rules Squeeze EPA Scientists

No Way to Cool the Ultimate Greenhouse

New Sellafield Study Poses a Puzzle

EMF-Cancer Links: Yes, No, and Maybe

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RESEARCH NEWSHuman Embryo Cloning Reported 652

E 653New Protein Appears to BeLong-Sought Neural Inducer

Going for the Old: Ancient DNADraws a Crowd

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El Ninlo Metamorphosis Throws Forecasters 656

Lithium Hints at Possessed Stars

Nonlinear Codes Straighten Up-andGet to Work

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New Crater Age Undercuts Killer Comets M' 659

FRONTIERS IN NEUROSCIENCE

PERSPECTIVES

Singte MindM.Il . Posner:EX ::

Moieular Genetics of tNeuological:Diseases

jsJ.;B. Martin~rT M goati olbExcement ut Calum Signaling Innexcitable CellsX :t~~;0 ;0J. W. Putney Jr.

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ARTICLESThalam oal Oscllatns in the 679SleepingandAroused Brain

M. Steriade0.;A. M0cCormick. T. J SejnowskiNeurono mecaim fO~c8Recognition0? 0;f~K. TanhakaOida* Stress, Glumate, and 689Neu~rodegeeralv isorers f0t. f

J T Coylead .PuaiittfreProgaramed Ca11 Death and the 695Control f Call Survival:XLessons frm

McC.RfB. A. Bre,1.F. Burne,H. S. Colef, Y. Ishizaki, M. D. Jacobson

DEPARTMENTS

THIS WEEK IN SCIENCE

EDITORIALFrontiers in Neuroscience

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LETTERS 637NIH Support for Graduate Students: J. Hegde *

NCRR Funding Mechanisms: J. L. Vaitukaitis 9

Environmental Hazards: Real or Exaggerated?:M. D. Green; B. Weiss; D. Redfield * Carcinogeni-city Certification: P. Shubik * Excluded Gender?:D. Arnosti * Volcanology in Europe: F. Barberi eMesostructure Silicate Names: G. Stucky

SCIENCESCOPE

RANDOM SAMPLES

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BOOK REVIEWS 771Research and Relevant Knowledge, reviewed byD. A. Wilson * Galileo, Courtier, R. J. Blackwell *The Great Paleozoic Crisis, P. W. Signor * Atmo-spheric Remote Sensing by Microwave Radiometry,T. T. Wilheit * Vignettes * Books Received

INSIDE AAAS

PRODUCTS & MATERIALS

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mn Board of Reviewing Editors wGottfried SchatzJozef SchellRonald H. SchwartzTerrence J. SejnowskiEllen SolomonThomas A. SteitzMichael P. StrykerRichard F. ThompsonRobert T. N. TjianEmil R. UnanueGeerat J. Vermeij

Bert VogelsteinHarold WeintraubZena WerbGeorge M. WhitesidesOwen N. WitteWilliam A. WulfKeith Yamamoto

SCIENCE * VOL. 262 * 29 OCTOBER 1993

SCIENCE

653 & 713Noggin protein,identified as aneural inducer

John AbelsonFrederick W. AltDon L. AndersonMichael AshburnerStephen J. BenkovicDavid E. BloomFloyd E. BloomPiet BorstMichael S. BrownHenry R. BourneJames J. Bull

Kathryn CalameC. Thomas CaskeyDennis W. ChoiJohn M. CoffinPaul J. CrutzenRobert DesimoneNicole Le DouarinBruce F. EldridgePaul T. EnglundRichard G. FairbanksDouglas T. Fearon

Harry A. FozzardK. FriedrichTheodore H. GeballeMargaret J. GellerJohn C. GerhartRoger 1. M. GlassStephen P. GoffPeter N. GoodfellowCorey S. GoodmanStephen J. GouldIra Herskowitz

Eric F. JohnsonStephen M. KosslynMichael LaBarberaCharles S. Levings IllAlexander LevitzkiHarvey F. LodishRichard LosickDiane MathisAnthony R. MeansShigetada NakanishiRoger A. Nicoll

William H. Orme-Johnson I11Stuart L. PimmYeshayau PockerDennis A. PowersRalph S. QuatranoV. RamanathanDouglas C. ReesT. M. RiceErkki RuoslahtiDavid C. Rubie

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COVER

Salvador Dali's Raphaelesque Head Breaking (1951)portrays the logarithmic spirals of the rhinoceros horn,the dome of the Pantheon, and the contemplativeMadonna. Scientists are pushing the frontiers of neuro-science in all directions and may even enter into therealms of mathematics, architecture, and faith. This

RESEARCH ARTICLENeural Induction by the Secreted 713Polypeptide NogginT. M. Lamb, A. K. Knecht, W. C. Smith,S. E. Stachel, A. N. Economides, N. Stahl,G. D. Yancopolous, R. M. Harland

REPORTSLaser Ablation and the Production of 719Polymer FilmsG. B. Blanchet, C. R. Fincher Jr., C. L. Jackson,S. I. Shah, K. H. Gardner

Identification of Complex Aromatic 721Molecules in Individual InterplanetaryDust ParticlesS. J. Clemett, C. R. Maechling, R. N. Zare,P. D. Swan, R. M. Walker

The Effect of Changing Land Use on SoilRadiocarbonK. G. Harrison, W. S. Broecker, G. Bonani

Crustal Thickness on the Mid-AtlanticRidge: Bull's-Eye Gravity Anomalies andFocused AccretionM. Tolstoy, A. J. Harding, J. A. Orcutt

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The Manson Impact Structure: F 7294Ar/39Ar Age and Its Distal Impact Ejecta inthe Pierre Shale in Southeastern South DakotaG. A. Izett, W. A. Cobban, J. D. Obradovich,M. J. Kunk

Mississippian Fossils from Southern 732Appalachian Metamorphic Rocks and TheirImplications for Late Paleozoic TectonicEvolutionR. A. Gastaldo, G. M. Guthrie, M. G. Steltenpohl

Structure at 2.5 A of a Designed Peptide 734That Maintains Solubility of Membrane ProteinsC. E. Schafmeister, L. J. W. Miercke,R. M. Stroud

AAAS Board of Directors BE

special issue samples the variety in neuroscience. Seethe Editorial, the News story on page 653, the Re-search Article on page 713, and the section of Per-spectives and Articles beginning on page 673. [Trans-parency: Bridgeman/Art Resources, NY. Reproducedwith permission from Artists Rights Society, NY]

Analysis of a Nucleoprotein Complex:The Synaptosome of yb ResolvaseN. D. F. Grindley

Calcium Sparks: Elementary EventsUnderlying Excitation-Contraction Couplingin Heart MuscleH. Cheng, W. J. Lederer, M. B. Cannell

Microdomains with High Ca2+ Close to1P3-Sensitive Channels That Are Sensed byNeighboring MitochondriaR. Rizzuto, M. Brini, M. Murgia, T. Pozzan

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Alterations of a Zinc Finger-Encoding 747Gene, BCL-6, in Diffuse Large-Cell LymphomaB. H. Ye, F. Lista, F. L. Coco, D. M. Knowles,K. Offit, R. S. K. Chaganti, R. Dalla-Favera

Isolation of the Cyclosporin-Sensitive 750T Cell Transcription Factor NFATpP. G. McCaffrey, C. Luo, T. K. Kerppola, J. Jain,T. M. Badalian, A. M. Ho, E. Burgeon,W. S. Lane, J. N. Lambert, T. Curran,G. L. Verdine, A. Rao, P. G. Hogan

Nonuniform Probability of Glutamate 754Release at a Hippocampal SynapseC. Rosenmund, J. D. Clements, G. L. Westbrook

Functional Stoichiometry of ShakerPotassium Channel InactivationR. MacKinnon, R. W. Aldrich, A. W. Lee

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TECHNICAL COMMENTS c

Spatial Learning in Mutant Mice 760J. A. Deutsch; A. J. Silva, R. Paylor,J. M. Wehner, S. Tonegawa; S. G. N. Grant,T. J. O'Dell, K. A. Karl, P. L. Stein, P. Soriano,E. R. Kandel

Gravitational Separation in Polar Firn 763H. Craig; D. Raynaud, J. M. Bamola,J. Chappellaz, R. J. Delmas, C. Lorius, J. Jouzel,J. Schwander

2 Indicates accompanying featureF. Sherwood Rowland

Retiring President,Chairman

Eloise E. ClarkPresident

Francisco J. AyalaPresident-elect

Robert A. FroschFlorence P. Haseltinewilliamn A. Lester, Jr.

Alan SchriesheimJean'ne M. ShreeveChang-Lin TienWarren M. WashingtonNancy S. Wexler

William T. GoldenTreasurer

Richard S. NicholsonExecutive Officer

* SCIENCE (ISSN 0036-8075) is published weekly on Friday, exceptthe last week in December, by the American Association for the Ad-vancement of Science, 1333 H Street, NW, Washington, DC 20005. Sec-ond-class postage (publication No. 484460) paid at Washington, DC, and addi-tional mailing offices. Copyright 1993 by the American Association for theAdvancement of Science. The title SCIENCE is a registered trademark of theAAAS. Domestic individual membership and subscription (51 issues): $87 ($47allocated to subscription). Domestic institutional subscription (51 issues): $205.Foreign postage extra: Mexico, Caribbean (surface mail) $50; other coun-tries (air assist delivery) $95. First class, airmail, student and emeritus rateson request. Canadian rateswith GSTavailable upon request, GST #125488122.

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SCIENCE * VOL. 262 * 29 OCTOBER 1993

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