human genome project, gene therapy, and cloning
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Human Genome Project, Gene Therapy, and Cloning. Spring 2010 Adapted from the University of Utah Genetic Science Learning Center and The National Genome Research Institute, National Institutes of Health. The Human Genome Project. - PowerPoint PPT PresentationTRANSCRIPT
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Human Genome Project, Gene Therapy, and Cloning
Spring 2010
Adapted from the University of Utah Genetic Science Learning Center
and The National Genome Research Institute, National Institutes of Health
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The Human Genome Project An international effort to decipher the DNA
blueprint of a human being
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Human Genome Project Goals: To sequence & determine the exact order of the
nucleotides (A,C,T,G) for ALL of the DNA in a human cell
To determine which sections of DNA represent the individual genes
To store this information in databases for analysis
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DNA Sequencing
DNA Sequencing Tutorial
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Publishing the human genome
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Gene Therapy
1. Isolate the normal sequence for a gene and package it into a virus (vector).
2. Infect a target cell, usually the one with the illness, such as a liver or lung cell (remember cystic fibrosis).
3. The cell uses the normal sequence to produce the missing protein and is thus repaired.
Replacement of an abnormal protein with a normal one
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Success of Gene Therapy in Treating the Blind
YouTube: Gene Therapy
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Problems with Gene Therapy Short lived, so patients have to go through
multiple rounds
Immune response to foreign invaders
Problems with the viruses
Very expensive
Multigene disorders
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What is Cloning?
Cloning is the creation of an organism that is the EXACT genetic copy of the mother
Identical twins are natural clones, they share 100% of their DNA
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