Perfect fit!

Whatever your sample preparation requirements, we help bring the pieces together for the perfect solution to meet your GC/MS and LC/MS needs:

Automated Sample Prep

Standards & Dilution Series

SPE, Dispersive SPE (DPX), Online SPE (SPExos)

Dynamic Headspace (DHS), HS & SPME

Twister & Thermal Desorption/Extraction

Intelligent PrepAhead productivity

Application support at your service

What can we do for you?

We bring the pieces together!

HPLC 2008 – Special Edition

NewsletterGERSTEL, Inc.

Food Safety · Beverages · F lavors · Metabolomics · Mater ia l Emiss ions

News from GERSTEL Inc. - 701 Digital Drive, Suite J Linthicum - MD 21090 - Phone: (800) 413-8160 - E-mail: sales@gerstelus.com

GERSTEL QuickMix QuickMix is now available for the GERSTEL MPS ro-botic series. QuickMix en-ables extremely fast and efficient mixing and extrac-tion of samples as part of the automated sample preparation process. The mixing power is compara-ble to that of vortex mixing. The sample is agitated in a special tray on the module, depending on the vial size holding up to 6 samples at a time. The tray can be

exchanged to operate with 2 mL, 4 mL, and 20 mL vials. If need-ed, Quick-Mix can be configured with a heated tray. All sample preparation steps are set up by mouse-click in the MAESTRO software in stand-alone operation, fully integrated with Agilent Technologies® MassHunter or ChemStation, or coupled with soft-ware from AB Sciex™ or Thermo Scientific®

Cryostatic Cooling Device CCD 2GERSTEL CCD 2 delivers cryostatic cooling for the GERSTEL CIS, TDU and TDS systems. The CCD 2 enables fast and independent cooling of up to 2 systems to temperatures as low as -40 °C. The CCD 2 is a perfect replacement for cryogenic cooling when only moderate trap temperatures are required. The temperatures are simply set as part of the MAESTRO method for the analysis. The display on the CCD 2 enables the user to verify the actual temperature.

GERSTEL MPS liquidThe new MPS liquid is a highly efficient liquid autosampler for GC/MS and LC/MS analysis work. Focusing on the core tasks of an autosampler, the MPS liquid offers large sample capacity, modern intuitive software control, as well as the capability to perform key

sample preparation steps such as the addition of in-ternal standards or a derivatization reagent. The MPS

liquid helps you ensure that your laboratory offers fast, responsive and pro-ductive analysis work while delivering reliable and ac-curate results.

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Evaporation StationA six-position evaporation station (mVAP) is available for the GERSTEL MultiPur-pose Sampler (MPS robotic). Samples are concentrated at user defined temperature and vacuum, enabling significantly improved limits of detection and solvent exchange to a GC or HPLC compatible solvent.mVAP can evaporate solvent after SPE, Dispersive SPE (DPX) or liquid/liquid extrac-tion and combine this with in-jection into GC/MS or LC/MS.

Thermal Desorption Unit – TDU 2The new GERSTEL Thermal Desorption Unit (TDU 2) is the heart of the most flexible and powerful sample introduction platform available for your GC/MS.

The TDU 2 is a third generation Thermal Desorption instrument from GERSTEL, building on more than 20 years of experience. The TDU 2 offer the highest performance, new low split pneumatics for improved LODs, built-in alignment support for easy liner change, and automation performed by the MPS robotic offering high precision delivery of samples, Barcode reading capability and up to 240 TDU tube sample capacity in standard configurations.

The TDU 2 enables ultra-trace analysis of a wide range of samples. Mounted directly on top of the CIS inlet without the need for a transfer line, the TDU provides a completely inert sample path for best possible analyte recovery.

The GERSTEL MultiPurpose Sampler (MPS/MPS robotic) is extremely versatile. The system performs automated spiking of adsorbent tubes with liquid standards as well as multiple sample introduction techniques such as Liquid, HS, SPME plus the following seven: • Thermal Desorption of adsorbent packed tubes • Direct Thermal desorption/extraction of solid samples • Thermal Extraction of liquids in μ-vials • Dynamic Headspace – DHS and DHS Large (1 L) • Hot injection and trapping (HIT) for HS • Stir Bar Sorptive Extraction (SBSE) • Pyrolysis using the GERSTEL PYRO

It is extremely easy to add – or switch between – sample introduction techniques. All techniques are fully controlled by GERSTEL’s powerful, yet easy to use MAESTRO software. The complete integration of MAESTRO into Agilent’s GC/MS software allows set up through dropdown menus and combined storage and reporting of all method parameters.

Filtration / DNPH ElutionThe Filtration / DNPH Elution option for the GERSTEL MultiPur-pose Sampler (MPS robotic) enables automated clean-up of up to 98 samples or extracts using standard filters. Alternatively, up to 20 DNPH cartridges can be eluted to determine formaldehyde and lower aldehydes sampled from air. Filtration/Elution can be combined with sample preparation and introduction to an LC-

MS/MS- or GC/MS system. Fil-tration can significantly improve the reliability of the analysis and of the analysis system. Liquid transfer is performed with exact control of flow and volume for highly reproducible results. MAE-STRO software offers simple and efficient control by mouse-click, requiring no macro program-ming.

MPS roboticPRO

The MPS roboticPRO is a highly efficient GC/MS autosampler, optimized for flexibil-ity and throughput. MPS roboticPRO holds a significantly larger number of samples and provides fast, reliable and highly accurate processing of all tasks. The sampler can au-tomatically change between Liquid, Head-space, and SPME injection techniques. Thermal Desorption / Thermal Extraction, Dynamic Headspace (DHS) and Automat-ed Liner Exchange (ALEX) can be added for increased flexibility and performance.

SPME calibration with derivatization and other liquid handling tasks are set up by mouse click without program-ming steps using MAESTRO software under integrated GC/MS system con-

trol. Priority samples can be added at any time without stopping the ongoing analysis se-quence. PrepAhead pro-ductivity ensures that the

complete GC/MS system is fully utilized.

SID Barcode ReaderThe new Sample ID (SID) Barcode reader for the GERSTEL Mul-tiPurpose Sampler (MPS) uses a dual camera setup and im-age analysis for positive identification of samples. SID can be connected to a PC or LAN using USB connectivity. Fully imple-

mented into the MAESTRO software, SID en-ables independent sample logging or fully in-

tegrated sample ID transfer to the data file with multiple user-defined op-

tions for sample verification and the handling of deviations.

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Automated micro-scale chamber

A new fully automated micro-scale chamber analysis system, the DHS L 3.5, for material emission testing is available from GERSTEL based on standard 3.5” sorbent tubes as specified in regulated methods. Samples

are placed in individual inert chambers with a volume of up to 1 Liter at defined temperature and air

exchange. Analytes are automatically collected at user-defined intervals followed by thermal desorption in the new TD 3.5+ and GC/MS determination. Automa-ted spiking of standards onto sorbent tubes is performed for calibra-tion and qualification purposes.

Accurate Add :Accurate Transfer of Liquids for highest

precision using a bench-top Workstation

Highly accurate standard addition and generation of standards and dilution series can significantly improve the quality of analysis results. Several useful tools and techniques are presented and evaluated, in-cluding thermostating; weighing; Accurate Add function for improved sampler precision; and vial venting to eliminate vial pressure build-up.

Download the full text of AppNote 187: http://www.gerstel.de/pdf/AppNote-187.pdf

Automating the Accurate Transfer of Highly Volatile to Highly Vis-cous Liquids using a Bench-top Workstation.

www.gerstelus.com

GERSTEL, Inc. President

Robert J. Collins, Ph.D.

Major Products and ServicesMAESTRO Software: Operates GERSTEL modules and systems independently or available as integrated solutions with Agilent ChemStation/MassHunter, LECO ChromaTOF, AB Sciex Analyst®, Thermo Scientific Xcalibur, and others. One method and sequence table run the complete system including GC/MS or LC/MS.MultiPurpose Sampler MPS: GC, GC/MS, LC, and LC/MS autosampler and sample preparation robot. Performs thesample preparation techniques listed below and more:Automated Centrifugation, Solvent Evaporation, Weighing, Filtration, Vortexing, and Bar Code Reading

GERSTEL, Inc.701 Digital Drive, Suite J

Linthicum, MD 21090

Phone:(800) 413-8160

E-mail:sales@gerstelus.com

Company DescriptionGERSTEL develops and produces automated sample preparation and sample introduction accessories for GC, GC/MS, LC, and LC/MS. GERSTEL technology enhances productivity and significantly improves detection limits. GERSTEL is recognized by Agilent Technologies as one of their Premier Solution Partners. GERSTEL solutions can also be integrated into other leading manufacturers’ systems.

Markets Served• Food, beverages, flavors, and fragrances• Personal care and cosmetics• Material Emissions • Polymers and packaging • Extractables and Leachables• Metabolomics and Forensics• Environmental and industrial hygiene

Automated DPX: Dispersive SPE technique for fast, ef-ficient extraction and concentration of analytes.Automated SPE: Independent of LC/MS or GC/MS or com-bined with sample introduction. Based on standard cartridges. Dynamic Headspace (DHS) and DHS Large up to 1 L volume: Concentrates VOCs from liquids or solids for ultra-low LODs.Thermal Desorption System (TDS): Ultra-low detec-tion limits for VOCs and SVOCs up to n-C40. Performs thermal desorption/ extraction and pyrolysis.Thermal Desorption Unit (TDU): Highly flexible, auto-mated analysis of up to 196 gaseous, liquid, or solid samples.Twister® Stir Bar Sorptive Extraction (SBSE): Ultra trace-level determination of organic compounds in liquid matrices. Up to 1000 times more sensitive than SPME.Cooled Injection System (CIS): Universal PTV inlet for optimized GC performance. High temperature version up to 650 °C, cryostatic cooling.Automated Liner EXchange (ALEX): For samples with a heavy matrix load. Multidimensional GC with Column Switching: Complex separations using two or more columns.Olfactory Detection Port (ODP): For GC or GC/MS; complete with voice recognition, intensity indication, and peak annotation.Preparative Fraction Collector (PFC): For GC or GC MS using up to six traps.

FacilitiesFull applications support laboratory at US headquarters near Baltimore, Maryland and a partner applications laboratory in Chicago, Illinois. Our applications team enables GERSTEL to assist customers in applying GC and LC analysis techniques to the solution of real-world challenges.

GERSTEL, Inc.

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Forensic and Doping analysis

Dried Blood Spot Autosampler DBSA

The GERSTEL Dried Blood Spot Autosampler (DBSA) pro-cesses up to 368 samples on DBS cards for Forensic or

Doping analysis. Automation is performed using the GERSTEL MultiPurpose Sampler (MPS) under MAESTRO software control.

can be added to the desorption eluent for quality purposes if required. An eluate clean-up step can further be performed based on an on-line SPE module which can be integrated into the overall analysis system. The online SPE system (GERSTEL-SPExos ) is based on replaceable SPE cartridges, ensuring mini-mal sample to sample carry over while efficiently transferring the analytes to the LC-MS/MS system with best possible re-covery for best possible LODs. Finally, the card is released and the associated tubing thoroughly rinsed with solvent. The card is again photographed to enable full documentation of the sample area, which has been desorbed.

Conclusion: The fully automated DBSA system enables fast and reliable determi-nation of salient blood levels with excellent LODs. This is about as efficient as it gets.

DBS Card SPExos

Cartridge

Waste

LC(-MS/MS)

Schematic diagram of DBS flow-through desorption (FTDTM) and SPE clean-up. FTD is patented by, and is a registered Trade Mark of, Spark Holland B.V.

The DBSA operates integrated with the LC-MS/MS system, en-abling fast and reliable determination of blood levels.

The MPS transports a DBS card to a camera. An image recog-nition software evaluates the dried blood spot and the card is loaded into the desorption interface and clamped into posi-tion. A desorption eluent flows through a defined area of the blood spot desorbing the analytes based on the patented Flow Through Desorption technique (FTDTM); an internal standard