hpa axis support booklet - fxmed · shows that epa promotes cardiovascular health, joint mobility,...
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Functional & Integrative Medicine Ltd, 77 Austin St, PO Box 19033, Onekawa, Napier 4146 NZPh 0800 439 633 Fax 0800 439 630 [email protected] www.fxmed.co.nz
HPA Axis Support Booklet
Presented by:
Dr Kamal Karl MBBS, FRNZCGP, FACNEM, FNZCAM, FACCS
“HPA Axis Dysfunction in Chronic Disease Management” Webinar
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CONTENTS
Page
11
9
9
10
10
9
11
11
11
12
13
13
14
14
12
15
16
Product
Improve Glycemic Control
Berberine-500
GlucoFunction
Medi Restore
UltraChrome-500
Decrease Inflammatory Signalling
Boswelya Plus
Curcutex
CytoQuel
ProOmega 2000
Increase Circadian Signaling
5HTP-CR
Ayu-Phos
CortisolCalm
L-Tyrosine
Magnesium Glycinate
Sleep & Relax
Balance Neurotransmitters/Neurosteroids
5HTP-CR
Double Strength Zinc Picolinate
L-5MTHF
L-Tyrosine
Magnesium Glycinate
MethylFortify
Page
1
1
2
2
3
3
4
4
5
5
10
6
6
6
7
7
7
8
8
Product
Balance Cortisol Feedback Mechanisms
a-Drenal
Ashwagandha
Ayu-Phos
CortisolCalm
L-theanine
Adrenal Support - Protect Zone Reticularis
a-Drenal
Ashwagandha
C-RLA – Liposomal Vitamin C
CytoQuel
Nutrient Support for Adrenal Steroidogenesis
a-Drenal
C-RLA – Liposomal Vitamin C
Double Strength Zinc Picolinate
Magnesium Glycinate
Niacinamide B3
Stress B – complex
Functional Testing
DUTCH Complete
DUTCH Plus
IMPROVE GLYCEMIC CONTROL
1.
Berberine-500 Berberine is an alkaloid present in a number of plants, includingBarberry,Treeturmeric,Oregongrape,Goldensealand Goldthread. Although most well-known for itsantimicrobialactivity(againstbacteria,viruses,protozoans,helminthes, fungi, and Chlamydia), this plant extract alsodemonstratesimportantbenefitsfor:
• Blood-sugarmanagementandinsulinsensitivity.• Cardiovascularsupportandhealthylipidlevels.• Gastrointestinal health – eradication of bacteria
overgrowth(hydrogenicbacteria).• Biofilmdisruptoractivity.• Weight management.• Oncologysupport, immunemodulation,andcognitive
support.
In a three-month clinical study, 116 subjects with type 2 diabetesanddyslipidemiareceivedeither1gberberinedaily or placebo. Statistically significant decreases wereseenintheberberinegroupinfastingandpost-prandialglucose levels,hemoglobinA1c(HbA1c),triglycerides,andtotal- and LDL-cholesterol.
GlucoFunction
A combination of key nutrients, antioxidants and herbalextracts designed to promote healthy glucose uptake and metabolism,microcirculationandpancreaticfunction.
• Chromium,MagnesiumandZinc–keynutrientsinvolvedinglucosetransport,utilizationandgluconeogenesis.
• Gymnema sylvestre – shown to promote healthyglucose uptake into the intestines, supports enzymeactivity for glucose utilization and promotes healthypancreaticbetacellfunction.
• Bitter melon – supports kidney health and bloodglucose metabolism.
• Cinnamon – promotes healthy glucose and lipid metabolismbysupportinghealthyreceptoractivity.
• VitaminCandAlphalipoicacid–antioxidantsupport,redbloodcellandvascularhealth.
• Chromium – shown to bemost effective in reducingdepressive symptoms for those individuals withpronounced carbohydrate craving and over-eatingfeatureswhicharepresentin‘atypicaldepression’.
Suggested Use: 1-2 capsules twice daily.
Clinical Research Paper available from ThorneResearch:A versatile Botanical Compound With Wide Clinical Application available.
Suggested Use: 3 capsules daily, in divideddoses,beforefood.
IMPROVE GLYCEMIC CONTROL
Medi Restore
ResearchNutrition’sMediRestoreisagreattasting,highlyconcentrated nutritional support formula. The formula iscomprisedoflowallergen,synergisticingredientstosupportnumerousbodyprocessesandsystemsincludingdigestion,detoxification, immune function, inflammatory balance,energyproductionandhealthyweightmanagement.
• Providesacompletesourceofprotein,100%certifiedorganic protein –28gramsofproteinperserve.
• Serves as a nutritious meal replacement providing atherapeuticandcomprehensivedoseofBvitaminsandtrace minerals.
• Supports healthy gut membrane integrity.• Providesasourceofprebioticfibreforhealthyintestinal
flora.• Supportshealthydetoxificationandliverfunction.• Contains botanicals Silymarin (Milk Thistle) –
detoxification,antioxidantandliversupport.• Matcha Green Tea powder and Pomegranante husk –
fordigestionandmicrobialbalance.• Ginger –supportsdigestionandbalancedinflammatory
response. • AdditionalaminoacidsGlutamine,GlycineandTaurine
forextrasupport.• Dairy/WheyandSoyfreeandVeganfriendly.
2.
UltraChrome 500
UltraChrome is Thorne Research’s patented chromiumproduct, consisting of chromium arginate and chromium4-oxopyridine, 2,6-dicarboxylate. Compared to otherchromium compounds, including picolinates, thiscombination of chromium chelates appears to have thehighestbioavailability.
• Showntoprovidehightissuelevelsofchromium.• Helpsmaintainhealthybloodsugarlevels.
Each Level Scoop (22.88g) Contains:
Oryza sativa (Rice) seed extract concentrate ........... 10,000 mg equiv. Oryza sativa dry seed ...................... 100,000 mgPisum sativum (Pea) seed extract concentrate ....... 3,320 mg equiv. to Pisum sativum dry seed ............... 28,220 mgL-Glutamine .................................................................... 1,500 mgL-Glycine ......................................................................... 1,500 mgLarix (Larch) Arabinogalactan ........................................ 1,000 mgTaurine .............................................................................. 350 mgAscorbic Acid (Vitamin C) ............................................ 250 mgPalm Tocotrienols Complex (Mixed Vitamin E) .......... 110 mg(from environmentally sustainable source)Choline Dihydrogen Citrate ............................................... 30 mgThiamine Hydrochloride ..................................................... 20 mg equiv. to Thiamine ............................................ 17.8 mgRiboflavin-5-Phosphate Sodium ........................................... 5 mg equiv. to Riboflavin .......................................... 3.93 mgNicotinamide ...................................................................... 50 mgCalcium Pantothenate ....................................................... 55 mg equiv. to Pantothenic Acid ................................. 50 mgPyridoxal-5-Phosphate ........................................................ 15 mg equiv. Pyridoxine ......................................... 10.26 mgCalcium L-5-methyltetrahydrofolate ............................ 220 mcg equiv. Levomefolic acid (L-5MTHF) ................ 200 mcgHydroxocobalamin ......................................................... 200 mcgBiotin ............................................................................... 50 mcgCholecalciferol (Vitamin D3) .......................... (400 IU) 10 mcgMagnesium Citrate ………………………………........…......….. 322 mg equiv. elemental Magnesium …….................……. 50 mg Calcified Lithothamnion Species (Red Algae) .............. 157 mg equiv. to elemental Calcium ................................ 50 mgZinc Citrate Dihydrate ..................................................... 46 mg equiv. elemental Zinc ......................................... 15 mgManganese Glycinate ................................................... 3,700 mcg equiv. elemental Manganese ....................... 1,000 mcgSelenomethionine ............................................................ 130 mcg equiv. elemental Selenium ................................. 50 mcgChromium Nicotinate ……………………………….........…..... 200 mcg equiv. elemental Chromium ……...…................... 25 mcgMolybdenum Trioxide ………………………...........………....… 75 mcg equiv. elemental Molybdenum .......................... 50 mcgPotassium Iodide .............................................................. 65 mcg equiv. elemental Iodine ...................................... 50 mcg Silybum marianum (Milk Thistle) extract (80% Silymarin) ... 150 mg equiv. Silybum marianum dry seed ............... 10,500 mgPunica granatum (Pomegranate Husk) extract ................. 200 mg equiv. Punica granatum dry peel ................... 4,000 mgCamellia sinesis leaf (Matcha Green Tea) powder ............ 250 mg equiv. Caffeine .................................................... 4.5 mgZingiber officinale (Ginger) root powder ........................ 135 mg
Excipients: Medium Chain Triglycerides, Hypromellose, Xanthan Gum, Xylitol, Monk Fruit Extract, Stevia, Natural Vanilla Flavour, Colloidal Anhydrous Silica.
Suggested Use: 1 capsule one to two timesdaily.
Suggested Use:Blend,shake,orbrisklymix1-2scoops with at least 200ml of water/coconutmilk per day.
DECREASE INFLAMMATORY SIGNALING
Boswelya Plus
BoswelyaPlus™containsastandardizedextractofBoswelliaserrata, which supports a healthy inflammatory responseandhealthybloodcirculation. • Zingiber officinale (Ginger), Withania somnifera, and
Curcuma longa have long been used in Ayurveda tohelpprovidesupportforjointandcartilagefunction.
• Curcumin – supports the maintenance of a healthyinflammatoryresponse.
• Glucosamine sulphate and chondroitin – nutritionalsupportforhealthyjoints.
• Bromelain – supportsahealthyinflammatoryresponse.
3.
Curcutex
Curcutex delivers a highly absorbable form of curcumin,using soy-free proprietary Meriva® phytosome complextechnology.
• Curcumin – shown to significantly reduce oxidation,inflammationandpain,offeringthepotentialtosupportabroadrangeofhealthconditions.
• Anti-inflammatory properties – supporting gut, skinand brain.
• Antioxidant properties – supporting vascular andmitochondria.
• May assist muscle recovery, reduce joint pain andstiffness.
Suggested Use: 1 caplet twice to three timesdaily.
Suggested Use: 1-6 capsules daily.
DECREASE INFLAMMATORY SIGNALING
4.
CytoQuel
CytoQuel™ has been developed to promote healthycytokineactivity.Offersyourpatientsaneffectivenewtoolinthequestforhealthyinflammationlevels.
• N-Acetyl-L-Cysteine (NAC) – promotes healthy NF-KBeta,IL-6,IL-8levels.
• BlackTeaExtract –polyphenol EGCGexert their anti-inflammatoryeffectsthroughtheinhibitionoftheNF-Kß signaling pathway, which decreases expression ofseveralinflammatoryproteins.
• CurcuWINTurmericExtract–46%betterabsorbedthanstandard curcumin.
• DeltaGold Tocotrienols – contains pure delta and gamma tocotrienols.
• Resveratrol–naturalTrans-resveratrolinhibitsavarietyofpro-inflammatorycompounds.
ProOmega 2000
Oneofourmostconcentratedformulas,highlevelsofEPAand DHA for those needing intensive support. Researchshows that EPA promotes cardiovascular health, jointmobility, proper immune function, and gastrointestinalhealth. EPA has also been shown to support a healthy mood.
• Deliciousnaturallemonflavour.• HighlyconcentratedEPAandDHAformula.• Promotescardiovascularhealth.• Promotesbrain,eye,andneurologicalhealth.• Supportsgastrointestinalhealth.• Helpsoptimizeimmunefunction.• Triglyceride form for better absorption of essential
omega-3s.• Contains Essential Fatty Acids (EFA) to help with
inflammatorysignaling.
Suggested Use:1capsuledailywithamealforthefirstweek,and3capsulesdailywithamealin week two and beyond.
Suggested Use: 2 capsules once to twice daily withfood.
INCREASE CIRCADIAN SIGNALING
5-HTP CR 100mg
5-hydroxytryptophan (5-HTP) is a precursor to serotonin.Supplementingwith5-HTPbypassesthesomewhatlimitedconversion of tryptophan to 5-HTP. Oral 5-HTP is well-absorbedintheintestinewithouttheneedforatransporter;otheraminoacidsdonotcompetewithitforabsorption.
• Supportshealthybiosynthesisofserotonin.• Supportshealthymoodandpositiveoutlook.• Promotesanormalappetiteandarestfulsleeppattern.• 5-HTP CR – controlled released tablet designed to
naturallyincreasethebody’slevelofserotoninquicklyandsteadilyovera12-hourperiod.
5.
Ayu-Phos
AyuPhos™ is soy-free and is naturally derived fromsunflowers. Phosphatidylserine is a natural phospholipidessentialforpropercellfunctionandsignalingandisfoundinparticularlyhighlevelsinthebrain.
• An important cell membrane phospholipid.• Promotescognitivefunction,ahealthystressresponse
and sleep. • Supportsmentalacuity,memoryandhealth.• Promotesemotionalwell-being.• Helpsmodulatecortisollevelsduringstress.• Improvescelltocellcommunicationinthebrain.• Improves cell metabloism (glucose utilisation) and
enhancedneurotransmitterformation.• Enhancesrecoveryfromstrenuousexercise.• Boundtoioniccalciumandmagnesiumwhichimprove
theabsorptionandutilizationofphosphatidylserineinthe body.
Suggested Use: 1 capsule once to twice daily.
Suggested Use: 1-3 tablets daily, individualdoses,beforemeals.
Magnesium Glycinate
Magnesiumactivatestheenzymesnecessaryforanumberof physiological functions, including neuromuscularcontractions, cardiac function, and the regulation of theacid-alkaline balance in the body.
• Magnesiumisanutritionalcofactorforserotonin.• ThisvitalmineralalsohelpsutilizeB-complexvitamins,
vitaminC,andvitaminE.• Magnesium also plays important roles in muscle
function,moodandcalming,andcranialvesselcomfort.• Magnesium helps activate neurotransmitters that are
responsibleforcalmingthebodyandthemind.• May help prepare your body andmind for sleep, by
calmingthenervoussystem.• Italsoregulatesthehormonemelatonin,whichguides
sleep-wake cycles in your body.
INCREASE CIRCADIAN SIGNALING
Sleep & Relax
Sleep&Relaxformula–ablendoforganicherbstraditionallyrecognized to support tranquil sleep, promotes a healthysleep cycle by calming tension and helping the mind unwind.
• Valerian–helpsimprovequalityofsleep,andreducesthetimeittakestofallasleep.Valeriandoesnotcausesomnolenceinthemorningoraffectdreamrecall.
• Passionflower – a knownnervine relaxant. Passiflorahasbeendemonstratedtocauseallostericmodulationof GABA-A receptor complex via interaction at thebenzodiazepinesite.
• Lemonbalm,Californiapoppy,LavenderandMarjoram–aproprietaryblendofcalming,restorativeherbs.
• Botanicalsofferawell-tolerated,lowtoxicityoptionforimprovingsleepquality.
• Aidsrelaxationandcalmsnervousagitation.• Promotesrelaxingandrestorativesleep.
6.
Suggested Use: 1–4capsulesdaily, individeddoses,withmeals.
Suggested Use: 2-3 capsules one to two hours beforebed.
L-Tyrosine
L-tyrosine is an amino acid precursor for synthesis of theneurotransmitters norepinephrine and dopamine. Thisimproved rate of neurotransmitter synthesis, stimulatesthecentralnervoussystem.L-tyrosineappearstofunctionasanadaptogenbyrelievingphysical symptomsofstress,suchasmoodswings.ChronicallystressedindividualsmaynotefficientlyconvertphenylalaninetoL-tyrosine,makingsupplementationwithL-tyrosinedesirable.
• Essential for neurotransmitter and thyroid hormonesynthesis. Supports the thyroid gland.
• Stimulatesgrowthhormoneandisinvolvedinadrenalandpituitaryfunction.
• A powerful antioxidant, scavenging and neutralizingfreeradicalsandinhibitingfatoxidation.
• Promotes a positive mental state and healthy stressmanagement.
Suggested Use: 1capsulethreetimesdaily.
25mg
7.
BALANCE NEUROTRANSMITTERS/NEUROSTEROIDS
Double Strength Zinc Picolinate
Zinc is essential for growth, immune system function,testosteronemetabolism,asacofactorfortheantioxidantenzymesuperoxidedismutase,andformanyotherfunctionsinthebody.Zincisinvolvedinthefunctioningofover200enzymes and plays a key role in genetic expression, celldivision, and growth. Zinc deficiency has been associatedwith adverse impacts on a number of structures andfunctionsofthebody.
• Zinc deficiency is common in those who suffer fromPyrolledisorder(Pyroluria)duetoHPLbindingtozinc,renderingitunavailablefornormalfunctions.
• Essentialforgrowthandimmunefunction.• Promotesreproductivehealth.• Picolinicacidfacilitatestheabsorptionofminerals,Zinc
Picolinate is absorbed to a higher degree than other zincsupplements.
5-HTP CR 100mg
5-hydroxytryptophan (5-HTP) is a precursor to serotonin.Supplementingwith5-HTPbypassesthesomewhatlimitedconversion of tryptophan to 5-HTP. Oral 5-HTP is well-absorbedintheintestinewithouttheneedforatransporter;otheraminoacidsdonotcompetewithitforabsorption.
• Supportshealthybiosynthesisofserotonin.• Supportshealthymoodandpositiveoutlook.• Promotesanormalappetiteandarestfulsleeppattern.• 5-HTP CR – controlled released tablet designed to
naturallyincreasethebody’slevelofserotoninquicklyandsteadilyovera12-hourperiod.
Suggested Use: 1 capsule once daily.
Suggested Use: 1-3 tablets daily, individualdoses,beforemeals.
L-5MTHF
Research Nutrition’s L-5MTHF is a pure and highlybioavailable form of folate. Directly facilitating methylgroupdonation in thebody, L-5MTHF supportsnumerousmetabolic processes for optimum healing, development,detoxification,mentalhealthandwellbeing.
• Providesamethylatedandmetabolicallyactiveformoffolate.
• Bypasses the biochemical steps normally required by otherfolates.Demonstratesgreatermetabolicactivitythan folic acid as a source of folate, with reducedpotentialforsideeffects.
• Contributestothenormalgrowthofthefoetusduringpregnancy.
• May support normal stress and cognitive functionthroughhealthyneurotransmitterproduction.
• Supportshealthyredbloodcellformation.• Plays an important role in supporting healthy
methylation.• Supports healthy homocysteine levels, cardiovascular
andvascularendothelialfunction.
Suggested Use: 1 capsule daily.
BALANCE NEUROTRANSMITTERS/NEUROSTEROIDS
8.
Methyl Fortify
Invaluablefordeliveringhighlyfocusedclinicalmethylationsupport,andtheoptimisationofcardiovascular,neurologicalanddetoxificationfunction.
• ProvidestheexternallymethylatedformsoffolateandvitaminB12.
• Activated forms of vitamin B2 and B6 provide crucialco-factorsupportforthepropermetabolismoffolate,B12andmethylation.
• ProvidesatherapeuticdoseofcholineforsupportofthealternateBHMThomocysteinemethylationpathway.
• May help to support the maintenance of healthyhomocysteinelevelsviaremethylationofhomocysteineback to methionine.
Magnesium Glycinate
Highly bioavailable magnesium chelate for sensitiveindividuals. Magnesium activates the enzymes necessaryfor a number of physiological functions, includingneuromuscular contractions, cardiac function, and theregulationoftheacid-alkalinebalanceinthebody.
• Magnesiumisanutritionalcofactorforneurotransmitterserotonins. Helps activate neurotransmitters that areresponsibleforcalmingthebodyandthemind.
• The body uses Magnesium for of 300 enzymaticreactions.
• ThisvitalmineralalsohelpsutilizeB-complexvitamins,vitaminC,andvitaminE.
• Magnesium also plays important roles in muscle function,moodandcalming,andcranialvesselcomfort.
Suggested Use: 1–4capsulesdaily, individeddoses,withmeals.
Suggested Use: 1 capsule daily.
Suggested Use: 1capsulethreetimesdaily.
L-Tyrosine
L-tyrosine is an amino acid precursor for synthesis of theneurotransmitters norepinephrine and dopamine. Thisimproved rate of neurotransmitter synthesis, stimulatesthecentralnervoussystem.L-tyrosineappearstofunctionasanadaptogenbyrelievingphysical symptomsofstress,suchasmoodswings.ChronicallystressedindividualsmaynotefficientlyconvertphenylalaninetoL-tyrosine,makingsupplementationwithL-tyrosinedesirable.
• Essential for neurotransmitter and thyroid hormonesynthesis. Supports the thyroid gland.
• Stimulatesgrowthhormoneandisinvolvedinadrenalandpituitaryfunction.
• A powerful antioxidant, scavenging and neutralizingfreeradicalsandinhibitingfatoxidation.
• Promotes a positive mental state and healthy stressmanagement.
BALANCE CORTISOL FEEDBACK MECHANISMS
9.
Ashwagandha
Ashwagandha, also known as Indian ginseng, and a dailyrasayana is one of the most highly regarded and widelyusedAyurvedicherbs. It acts as an adaptogen to supporttheimmunesystem,nourishingandstrengtheningtheinnerreserveofthehumanbody.
Suggested Use: 1capsuletwicetothreetimesdaily.
Suggested Use: 1 capsule once to twice daily.
• The key constituents of Ashwagandha, withanoloids,plan an important role in its ability to promote physical andmentalhealth,i.e.occasionalstress,cognitiveandbrain function, immune system support and healthymetabolism.
• The withanolides serve as important hormoneprecursors that convert into human physiologichormones as needed by the body that act as a natural anti-inflammatory.
• Helpsrestorevitalitytothosesufferingfromoverworkornervousexhaustion,oracute/chronicstress.
• Promotes physical and mental health. • Anti-stressandsupportivetotheadrenalglands.• Supportstheactivityoflymphocytesandmacrophages
andmaypromotethyroidfunctionhealth.
Ayu-Phos
AyuPhos™ is soy-free and is naturally derived fromsunflowers. Phosphatidylserine is a natural phospholipidessentialforpropercellfunctionandsignalingandisfoundinparticularlyhighlevelsinthebrain.
• An important cell membrane phospholipid.• Promotescognitivefunction,ahealthystressresponse
and sleep. • Supportsmentalacuity,memoryandhealth.• Promotesemotionalwell-being.• Helpsmodulatecortisollevelsduringstress.• Improvescelltocellcommunicationinthebrain.• Improves cell metabloism (glucose utilisation) and
enhancedneurotransmitterformation.• It is also helpful during recovery from strenuous
exercise. • This flower-powered brain food is bound to ionic
calciumandmagnesiumwhichimprovetheabsorptionandutilizationofphosphatidylserineinthebody.
10.
BALANCE CORTISOL FEEDBACK MECHANISMS
Cortisol Calm
Cortisol Calm is a blend of herbal extracts and vitamin Ddesignedtomaintainhealthycortisollevelsandtosupportrelaxation,restfulsleepandpositivemoodduringtimesofstress.
• In a recent study, Sensoril® Ashwagandha extractpromoted relaxation and maintained healthycortisol and C-reactive protein levels. Subjects in thisrandomized, double blind, placebo-controlled studyreportedsupportforhealthysleep,positivemoodandcognitivefunction.Theeffectsweremostpronouncedforsubjectstaking500mgperdaycomparedtolesserdoses.
• Rhodiola and Magnolia – supports healthy adrenal cortisolactivityandofferssupportforstress,moodandemotionalwell-being.
• L-Theanine – supports normal brain alpha-waveactivity,helpingcalmthesympatheticnervoussystemforarelaxingeffect.
• Vitamin D – recent research suggests that maintaining healthy vitamin D levels supports normal cortisolproductionwithinabdominaladipocytes.
L-Theanine
L-Theanine is a naturally occurring, amino acid found ingreen tea leaves. L-Theanine has shown to reduce stressby promoting relaxation without drowsiness, easingnervousness due to overwork and fatigue, and reducingnervousirritability.
• Supportsnervoussystemhealthandfunction.• May reduce systolic and diastolic blood pressure.• Supportsantioxidantanddetoxificationmechanisms.• Increases levels of dopamine and improves mental
awareness.• IncreasesGABAandreducesrestlessness,insomniaand
otherdisruptedconditions.• L-Theanine – supports normal brain alpha-wave
activity,helpingcalmthesympatheticnervoussystemforarelaxingeffect.
• L-theanine also appears to support neurological health by exerting a positive and significant impactonneurotrophicfactorsinthebrainandassistingcell-signalingactivity.
• Research suggests that L-theaninepositively supportsoverall nervous system health and activity due to itspositive effects on serotonin, dopamine, and GABAlevels, as well as its modulation of excitatory andinhibitory neurotransmission.
Suggested Use: 1 capsule in the morning and eveningwithmeals.
Suggested Use: 1-2 capsules twice daily.
ADRENAL SUPPORT - PROTECT ZONE RETICULARIS
11.
a-Drenal
Provides comprehensive support from stress inducedsymptoms, supportsadrenal functionandpromotescalm,balanced physical and mental energy.
• Comprehensive formulation of organic adrenal tissueand adaptogenic herbs.
• Helps maintain and normalize healthy cortisol andbloodsugarlevels.
• Supportshealthyadrenalfunction.• The adrenal cortex is responsible for synthesis of
corticosteroids therefore adrenal extracts play a rolein supporting normal adrenal function and healthycortisollevels.Thishelpsmaintainnormalimmuneandstressresponsesandmanyothervitalprocessesinthebody.
• Beta-Sitosterol – a plant sterol, known to aid theimmune system by maintaining a healthy balance between Th-1 and Th-2 white blood cells. It also helps tomodulatethestressresponsebysupportingnormalcortisolandDHEAlevels.
Suggested Use: 2 capsules twice daily.
CytoQuel
CytoQuel™ has been developed to promote healthycytokineactivity.Offersyourpatientsaneffectivenewtoolinthequestforhealthyinflammationlevels.
• N-Acetyl-L-Cysteine (NAC) – promotes healthy NF-KBeta,IL-6,IL-8levels.
• BlackTeaExtract –polyphenol EGCGexert their anti-inflammatoryeffectsthroughtheinhibitionoftheNF-Kß signaling pathway, which decreases expression ofseveralinflammatoryproteins.
• CurcuWINTurmericExtract–46%betterabsorbedthanstandard curcumin.
• DeltaGold Tocotrienols – contains pure delta and gamma tocotrienols.
• Resveratrol–naturalTrans-resveratrolinhibitsavarietyofpro-inflammatorycompounds.
Suggested Use: 1 capsule daily with a meal for thefirstweek,and3capsulesdailywithameal in week two and beyond. They may be taken at the same meal or spread amongst your meals.ForbestresultstakeawayfromVitaminE(tocopherol).
C-RLA
C-RLA™ offers a safe, efficacious delivery system of highdoseVitaminCandR-LipoicAcidinoneformulation.
• Eachservingcontains1500mgofVitaminCand70mgof R-Lipoic Acid in a natural (GMO-free) liposomalpreparation.
• Lipoic acid helps protect against oxidative stressgeneratedbyhighglucoselevels.
• The pure R-Lipoic Acid in C-RLA™ supports a healthy inflammatory response and is a potent free-radicalscavenger. Suggested Use:10ml (twoteaspoons)onceor
twiceperday,awayfromfood.
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NUTRIENT SUPPORT FOR ADRENAL STEROIDOGENESIS
Suggested Use: 2 capsules twice daily.
a-Drenal
Provides comprehensive support from stress inducedsymptoms, supportsadrenal functionandpromotescalm,balanced physical and mental energy.
• Comprehensive formulation of organic adrenal tissueand adaptogenic herbs.
• Helps maintain and normalize healthy cortisol andbloodsugarlevels.
• Supportshealthyadrenalfunction.• The adrenal cortex is responsible for synthesis of
corticosteroids therefore adrenal extracts play a rolein supporting normal adrenal function and healthycortisollevels.Thishelpsmaintainnormalimmuneandstressresponsesandmanyothervitalprocessesinthebody.
• Beta-Sitosterol – a plant sterol, known to aid theimmune system by maintaining a healthy balance between Th-1 and Th-2 white blood cells. It also helps tomodulatethestressresponsebysupportingnormalcortisolandDHEAlevels.
Stress B-complex
A vitamin B-complex with extra B5 for adrenal supportandstressmanagement.StressB-ComplexcontainsactiveB-vitamin forms for enhanced absorption. Healthy HPAaxis play an important role inmanaging stress effectively.Pantothenic acid (vitamin B5) is part of the B-vitamincomplex and is essential for healthy adrenal and immunefunction. In particular, pantothenic acid serves as thestartingmaterialforthesynthesisofcoenzymeA,whichisimportant formetabolismof fatsandsynthesisofadrenalhormones.Pantothenicacidplaysakeyroleintheformationof acetylcholine, which is needed in the transmission ofnerveimpulses.
• Stress B-Complex consists of a group of eight water-soluble compounds.
• Although each B vitamin is chemically distinct, theyregularly work together in various biochemicalfunctions throughout the body – including cellularenergy production, healthy red-blood-cell formation,andhealthyneurologicalfunction.
• Most B vitamins, with the exception of vitamin B12,are not stored in the body; consequently, theymustbe acquired daily from the diet in order tomaintainoptimalhealth.
Suggested Use: 1 capsule one to three timesdaily.
13.
NUTRIENT SUPPORT FOR ADRENAL STEROIDOGENESIS
C-RLA
C-RLA™ offers a safe, efficacious delivery system of highdoseVitaminCandR-LipoicAcidinoneformulation.
• Eachservingcontains1500mgofVitaminCand70mgof R-Lipoic Acid in a natural (GMO-free) liposomalpreparation.
• Lipoic acid helps protect against oxidative stressgeneratedbyhighglucoselevels.
• The pure R-Lipoic Acid in C-RLA™ supports a healthy inflammatory response and is a potent free-radicalscavenger.
25mg
Suggested Use:10ml (twoteaspoons)onceortwiceperday,awayfromfood.
Double Strength Zinc Picolinate
Zinc is essential for growth, immune system function,testosteronemetabolism,asacofactorfortheantioxidantenzymesuperoxidedismutase,andformanyotherfunctionsinthebody.Zincisinvolvedinthefunctioningofover200enzymes and plays a key role in genetic expression, celldivision, and growth. Zinc deficiency has been associatedwith adverse impacts on a number of structures andfunctionsofthebody.
• Zinc deficiency is common in those who suffer fromPyrolle disorder (Pyroluria) due to HPL binding tozinc, rendering it unavailable for normal functions.Supplementing with Zinc Picolinate may reducePyrolle levelsandseverityof thesignsandsymptomsexperienced.
• Essentialforgrowthandimmunefunction.• Promotesreproductivehealth.• Picolinicacidfacilitatestheabsorptionofminerals,Zinc
Picolinate is absorbed to a higher degree than is other zincsupplements.
• Contains25mgofzincpercapsule.
Suggested Use: 1 capsule once daily.
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NUTRIENT SUPPORT FOR ADRENAL STEROIDOGENESIS
Niacinamide B3
Research Nutrition’s Niacinamide B3 is a pure andhypoallergenicsourceofnon-flushingvitaminB3.Supportingcellular mitochondrial energy production and anti-aging,detoxification,skinprotection,andcalmingofneurologicalover-excitation(includingfromover-methylation).
• Nicotinamide improves choline retention and mayassist intheconsumptionofexcesscirculatingmethylgroups.
• Thisoptimisationofnicotinamideand choline/methylgroup availability is important for brain function andthepreventionofdegenerativeneurologicalconditions.
• EssentialtotheformationofNADandNADP,involvedinover400enzymereactionsinthebody.
• Assists the metabolism of carbohydrates, fats, andproteins.
• Mayhelpcalmthenervoussystem.• May assist in the detoxification of alcohol and the
recyclingofglutathione.• Enhancesmitochondrialquality,functionandlifespan.
Magnesium Glycinate
Highly bioavailable magnesium chelate for sensitiveindividuals. Magnesium activates the enzymes necessaryfor a number of physiological functions, includingneuromuscular contractions, cardiac function, and theregulationoftheacid-alkalinebalanceinthebody.
• Magnesiumisanutritionalcofactorforneurotransmitterserotonins.
• The body uses Magnesium for of 300 enzymaticreactions.
• ThisvitalmineralalsohelpsutilizeB-complexvitamins,vitaminC,andvitaminE.
• Magnesium also plays important roles in muscle function,moodandcalming,andcranialvesselcomfort.
• Nutrient Utilization; Bone Health and CardiovascularSupport.
• Supports metabolism of carbohydrates, amino acidsandfats;alsoforenergyproduction,andtheutilizationofcalcium,phosphorus,sodium,andpotassium.
• Supports sleep.
Suggested Use: 1–4capsulesdaily, individeddoses,withmeals.
Suggested Use: 1-4 capsules daily.
FUNCTIONAL TESTING
DUTCH Complete
Thisadvancedhormonetestingwasdevelopedtosurpassindustrystandardsforavailabletestingoptions.DUTCHtestingoffersthemostextensiveprofileofsexandadrenalsteroidhormones,alongwiththeirall-importantmetabolites.Thedaily(diurnal)patternoffreecortisol,alongwithmelatoninisincluded.Thisuniquecombinationofclinicalinformationisnotavailablebyanyothertestingmethod.
Thisadvancedhormonetestingwasdevelopedtosurpassindustrystandardsforavailabletestingoptions.DUTCHtestingoffersthemostextensiveprofileofsexandadrenalsteroidhormones,alongwiththeirall-important metabolites.
EFFECTIVE HRT MONITORING
DUTCHtestingwasspecificallymadetobeoptimallyeffectiveformostformsofhormonereplacementtherapy.Uniquemethodsareusedforimprovedmonitoringoforalprogesteroneandvaginalhormones.
THE EASIEST COLLECTION
Patientscollectjustfourorfivedriedurinesamplesovera24-hourperiod.Driedspecimensamplesareconvenienttocollect,easytoshipandstableforseveralweeks.
CLINICAL VALIDATIONAllPrecisionAnalyticaltestingmethodsgothrougharigorousandongoingvalidationprocesstoverifyaccuracy,precision,recovery,linearity,etc.inthepursuitofthe most accurate and precise techniques availableforhormonetesting.
15.
The DUTCH Plus™ Report includes:
DUTCH Complete (MetabolitesofEstrogens,Androgens,Progesterone,Cortisol,Melatoninand8-OHdG).PLUSCortisol Awakening Response (CAR)-showsincrementalcortisollevelsuponwaking,whichprovidesvaluableinformationonHPAAxisfunction.
What is the Cortisol Awakening Response and how do we test for it?• Uponwaking,cortisollevelsnaturallybegintoriseby50%.30minutesafterwaking,cortisollevelswillstillshowthis
sharpincrease.By60minutesafterwaking,cortisollevelshavepeakedandbegintodecline.• Measuringthisriseandfallofcortisollevelsatwakingcanbeusedasa“ministresstest”.• ResearchshowsthatthesizeofthisincreasecorrelateswithHPAAxisfunction,evenifthesamplemeasurementsare
all within range. • TheassessmentofthisendocrineresponseisabletouncoversubtlechangesinHPAAxisactivity,whichisassociated
withvarioushealthconditionsandriskfactors.• Aquicksaturationofsalivaswabsuponwaking,andat30and60minutesafterwaking,providewhatisrequiredto
assessapatient’sCortisolAwakeningResponse.
A low Cortisol Awakening Response • ThiscanbearesultofanunderactiveHPAAxis,excessivepsychologicalburnout,seasonalaffectivedisorder(SAD),
sleepapneaorpoorsleepingeneral,PTSD,chronicfatigueand/orchronicpain.• AdecreasedCARhasalsobeenassociatedwithsystemichypertension,functionalGIdiseases,postpartum
depression,andautoimmunediseases.
An elevated Cortisol Awakening Response• Thiscanbearesultofanover-reactiveHPAAxis,ongoingjobrelatedstress(anticipatorystressfortheday),glycemic
dysregulation,pain(i.e.wakingwithpainfuljointsormigraine),andgeneraldepression(notSAD).• Arecentstudyshowedthatneitherthewakingnorpost-wakingcortisolresultscorrelatedtoMajorDepressive
Disorder,buttheCARcalculation(thechangebetweenthefirsttwosamples)did.• Thismeasurementoftheresponsetowakinghasindependentclinicalvalueshowingdysfunctionthatmaybehidden
bycurrenttestingoptions.
What’s Included in the DUTCH Plus™? • TheDUTCHPlus™usesfourdriedurinesamplesandfivesalivasamples.• Thesesamplesarecollectedoverthecourseofoneday,fromwakingtobedtime.
FUNCTIONAL TESTING
16.
Functional & Integrative Medicine Ltd, 77 Austin St, PO Box 19033, Onekawa, Napier 4146, NZPh 0800 439 633 Fax 0800 439 630 [email protected] www.fxmed.co.nz
PleasecallourTechnicalSupportTeamon0800439633ifyouhavefurtherquestionsoremail [email protected]
Australian customerspleasecontactoursistercompanyResearchNutritionforfurtherinformationontestingor
ResearchNutritionproductsmentionedinthisbooklet.Phone:1800110158orEmail:[email protected]