hormonal systems: all cancers 1 - ccss€¦ · hormonal systems: all cancers 3 ccss data from...
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Hormonal systems: All cancers 1
CCSS data from Dec2010 and March 2015 data freeze 1 N and % based on response of 'Yes' 2 'Any hormonal problem' is based on a response of 'Yes' to one or more of the listed hormonal problems
Overactive thyroid
(E.1/E.1) 1
Underactive thyroid
(E.2/E.2) 1
Thyroid nodules (E.3/E.3) 1
Thyroid enlargement
(E.4/E.4) 1
Diabetes- diet (E.5/E.5)
1
All cases N % N % N % N % N %
Both sexes All cases 24362 428 1.8 2507 10.4 547 2.3 567 2.3 294 1.2
Age at baseline <18 5645 44 0.8 379 6.8 32 0.6 45 0.8 31 0.6
18-19 2102 24 1.2 159 7.6 27 1.3 31 1.5 15 0.7
20-24 5722 82 1.4 498 8.8 84 1.5 113 2.0 59 1.0
25-29 5186 106 2.1 569 11.1 119 2.3 147 2.9 75 1.5
30-34 3558 110 3.1 513 14.5 147 4.2 120 3.4 65 1.8
35+ 2149 62 2.9 389 18.2 138 6.5 111 5.2 49 2.3
Years since diagnosis 5-9 2581 25 1.0 175 6.8 10 0.4 25 1.0 13 0.5
10-14 8323 123 1.5 818 9.9 108 1.3 133 1.6 81 1.0
15-19 7727 148 1.9 807 10.5 183 2.4 197 2.6 81 1.1
20+ 5731 132 2.3 707 12.5 246 4.3 212 3.7 119 2.1
Age at diagnosis <1 1842 13 0.7 100 5.5 16 0.9 17 0.9 21 1.1
1-4 7771 92 1.2 576 7.5 101 1.3 124 1.6 58 0.7
5-9 5487 92 1.7 565 10.4 124 2.3 134 2.5 61 1.1
10-14 5181 125 2.4 602 11.7 156 3.0 153 3.0 83 1.6
15-20 4081 106 2.6 664 16.4 150 3.7 139 3.4 71 1.7
Treatment Surgery only 2068 24 1.2 69 3.4 12 0.6 24 1.2 16 0.8
Chemotherapy, no radiation 7360 61 0.8 265 3.6 61 0.8 91 1.2 89 1.2
Radiation, no chemotherapy 2017 57 2.9 453 22.7 105 5.3 81 4.1 11 0.5
Chemotherapy and radiation 10680 244 2.3 1551 14.6 338 3.2 335 3.2 158 1.5
Unknown 2237 42 1.9 169 7.6 31 1.4 36 1.6 20 0.9
Males All cases 13028 214 1.7 1163 9.0 163 1.3 200 1.5 118 0.9
Age at baseline <18 3041 33 1.1 223 7.4 15 0.5 24 0.8 15 0.5
18-19 1098 8 0.7 90 8.3 14 1.3 14 1.3 9 0.8
20-24 3013 39 1.3 250 8.3 26 0.9 37 1.2 22 0.7
25-29 2898 58 2.0 275 9.6 43 1.5 58 2.0 26 0.9
30-34 1884 44 2.4 192 10.3 36 1.9 36 1.9 26 1.4
35+ 1094 32 3.0 133 12.2 29 2.7 31 2.9 20 1.8
Years since diagnosis 5-9 1449 10 0.7 94 6.5 5 0.3 11 0.8 5 0.3
10-14 4458 69 1.6 412 9.3 40 0.9 57 1.3 33 0.7
15-19 4062 70 1.7 360 8.9 52 1.3 67 1.7 33 0.8
20+ 3059 65 2.2 297 9.8 66 2.2 65 2.2 47 1.5
Age at diagnosis <1 944 6 0.6 52 5.5 5 0.5 7 0.7 13 1.4
1-4 4070 53 1.3 312 7.7 38 0.9 48 1.2 25 0.6
5-9 3099 51 1.7 305 9.9 46 1.5 52 1.7 21 0.7
10-14 2742 53 1.9 258 9.5 38 1.4 43 1.6 26 1.0
15-20 2173 51 2.4 236 10.9 36 1.7 50 2.3 33 1.5
Treatment Surgery only 1028 13 1.3 29 2.8 3 0.3 7 0.7 8 0.8
Chemotherapy, no radiation 3870 32 0.8 108 2.8 14 0.4 25 0.7 38 1.0
Radiation, no chemotherapy 1046 29 2.8 205 19.7 34 3.3 28 2.7 3 0.3
Chemotherapy and radiation 5764 115 2.0 742 13.0 106 1.9 126 2.2 64 1.1
Unknown 1320 25 1.9 79 6.0 6 0.5 14 1.1 5 0.4
Females All cases 11334 214 1.9 1344 12.0 384 3.4 367 3.3 176 1.6
Age at baseline <18 2604 11 0.4 156 6.0 17 0.7 21 0.8 16 0.6
18-19 1004 16 1.6 69 6.9 13 1.3 17 1.7 6 0.6
20-24 2709 43 1.6 248 9.3 58 2.2 76 2.8 37 1.4
Hormonal systems: All cancers 2
CCSS data from Dec2010 and March 2015 data freeze 1 N and % based on response of 'Yes' 2 'Any hormonal problem' is based on a response of 'Yes' to one or more of the listed hormonal problems
Diabetes- pills
(E.6/E.6) 1
Diabetes- insulin
(E.7/E.7) 1
Growth hormone deficiency (E.8/E.8) 1
Osteoporosis (E.10/E.10) 1
Any hormonal problem2
All cases N % N % N % N % N %
Both sexes All cases 24362 233 1.0 365 1.5 1902 8.0 1107 4.6 5431 22.9
Age at baseline <18 5645 15 0.3 52 0.9 646 11.5 203 3.6 1026 18.4
18-19 2102 9 0.4 19 0.9 241 11.8 106 5.1 422 20.7
20-24 5722 41 0.7 81 1.4 525 9.4 273 4.8 1170 21.1
25-29 5186 64 1.3 93 1.8 364 7.2 262 5.1 1228 24.4
30-34 3558 51 1.5 66 1.9 104 3.0 167 4.7 916 26.6
35+ 2149 53 2.5 54 2.5 22 1.0 96 4.5 669 31.8
Years since diagnosis 5-9 2581 8 0.3 43 1.7 208 8.2 109 4.2 465 18.5
10-14 8323 39 0.5 109 1.3 706 8.6 397 4.8 1775 21.8
15-19 7727 66 0.9 99 1.3 590 7.8 336 4.4 1708 22.7
20+ 5731 120 2.1 114 2.0 398 7.1 265 4.7 1483 26.6
Age at diagnosis <1 1842 8 0.4 17 0.9 123 6.8 45 2.5 248 13.7
1-4 7771 60 0.8 74 1.0 917 12.0 309 4.0 1561 20.6
5-9 5487 43 0.8 66 1.2 616 11.5 298 5.5 1280 24.0
10-14 5181 58 1.1 122 2.4 213 4.2 286 5.6 1254 24.8
15-20 4081 64 1.6 86 2.1 33 0.8 169 4.2 1088 27.5
Treatment Surgery only 2068 11 0.5 11 0.5 36 1.8 35 1.7 174 8.6
Chemotherapy, no radiation 7360 67 0.9 98 1.3 158 2.2 302 4.1 887 12.3
Radiation, no chemotherapy 2017 20 1.0 20 1.0 272 14.2 80 4.0 771 39.8
Chemotherapy and radiation 10680 118 1.1 207 2.0 1285 12.3 607 5.7 3190 30.7
Unknown 2237 17 0.8 29 1.3 151 6.8 83 3.7 409 18.5
Males All cases 13028 108 0.8 166 1.3 1130 8.9 480 3.7 2611 20.5
Age at baseline <18 3041 7 0.2 22 0.7 392 13.0 114 3.8 604 20.1
18-19 1098 4 0.4 11 1.0 142 13.3 60 5.5 230 21.6
20-24 3013 17 0.6 37 1.2 309 10.5 121 4.0 581 19.8
25-29 2898 27 1.0 40 1.4 211 7.5 106 3.7 585 20.8
30-34 1884 27 1.5 32 1.7 64 3.5 46 2.5 361 19.8
35+ 1094 26 2.4 24 2.2 12 1.1 33 3.0 250 23.4
Years since diagnosis 5-9 1449 3 0.2 21 1.5 132 9.3 60 4.1 269 19.1
10-14 4458 19 0.4 49 1.1 428 9.8 191 4.3 909 20.8
15-19 4062 28 0.7 42 1.0 346 8.7 138 3.4 798 20.2
20+ 3059 58 1.9 54 1.8 224 7.5 91 3.0 635 21.3
Age at diagnosis <1 944 5 0.5 8 0.9 69 7.4 22 2.3 125 13.4
1-4 4070 26 0.6 31 0.8 542 13.5 145 3.6 827 20.7
5-9 3099 18 0.6 30 1.0 357 11.7 149 4.8 685 22.7
10-14 2742 28 1.0 53 1.9 143 5.3 108 4.0 544 20.3
15-20 2173 31 1.5 44 2.0 19 0.9 56 2.6 430 20.5
Treatment Surgery only 1028 6 0.6 7 0.7 25 2.5 18 1.8 87 8.7
Chemotherapy, no radiation 3870 29 0.8 48 1.2 87 2.3 123 3.2 390 10.3
Radiation, no chemotherapy 1046 10 1.0 6 0.6 144 14.4 34 3.3 362 36.2
Chemotherapy and radiation 5764 52 0.9 93 1.6 767 13.6 271 4.7 1560 27.8
Unknown 1320 11 0.8 12 0.9 107 8.2 34 2.6 212 16.2
Females All cases 11334 125 1.1 199 1.8 772 7.0 627 5.6 2820 25.6
Age at baseline <18 2604 8 0.3 30 1.2 254 9.8 89 3.4 422 16.5
18-19 1004 5 0.5 8 0.8 99 10.1 46 4.6 192 19.8
20-24 2709 24 0.9 44 1.6 216 8.2 152 5.7 589 22.5
Hormonal systems: All cancers 3
CCSS data from Dec2010 and March 2015 data freeze 1 N and % based on response of 'Yes' 2 'Any hormonal problem' is based on a response of 'Yes' to one or more of the listed hormonal problems
Overactive thyroid
(E.1/E.1) 1
Underactive thyroid
(E.2/E.2) 1
Thyroid nodules (E.3/E.3) 1
Thyroid enlargement
(E.4/E.4) 1
Diabetes- diet (E.5/E.5)
1
All cases N % N % N % N % N %
25-29 2288 48 2.1 294 13.0 76 3.3 89 3.9 49 2.2
30-34 1674 66 4.0 321 19.4 111 6.7 84 5.1 39 2.3
35+ 1055 30 2.9 256 24.4 109 10.4 80 7.7 29 2.8
Years since diagnosis 5-9 1132 15 1.3 81 7.2 5 0.4 14 1.2 8 0.7
10-14 3865 54 1.4 406 10.6 68 1.8 76 2.0 48 1.2
15-19 3665 78 2.1 447 12.3 131 3.6 130 3.6 48 1.3
20+ 2672 67 2.5 410 15.5 180 6.8 147 5.6 72 2.7
Age at diagnosis <1 898 7 0.8 48 5.4 11 1.2 10 1.1 8 0.9
1-4 3701 39 1.1 264 7.2 63 1.7 76 2.1 33 0.9
5-9 2388 41 1.7 260 11.0 78 3.3 82 3.5 40 1.7
10-14 2439 72 3.0 344 14.2 118 4.9 110 4.6 57 2.4
15-20 1908 55 2.9 428 22.6 114 6.0 89 4.7 38 2.0
Treatment Surgery only 1040 11 1.1 40 3.9 9 0.9 17 1.6 8 0.8
Chemotherapy, no radiation 3490 29 0.8 157 4.5 47 1.4 66 1.9 51 1.5
Radiation, no chemotherapy 971 28 2.9 248 25.9 71 7.4 53 5.6 8 0.8
Chemotherapy and radiation 4916 129 2.7 809 16.6 232 4.8 209 4.3 94 1.9
Unknown 917 17 1.9 90 9.9 25 2.7 22 2.4 15 1.6
Hormonal systems: All cancers 4
CCSS data from Dec2010 and March 2015 data freeze 1 N and % based on response of 'Yes' 2 'Any hormonal problem' is based on a response of 'Yes' to one or more of the listed hormonal problems
Diabetes- pills
(E.6/E.6) 1
Diabetes- insulin
(E.7/E.7) 1
Growth hormone deficiency (E.8/E.8) 1
Osteoporosis (E.10/E.10) 1
Any hormonal problem2
All cases N % N % N % N % N %
25-29 2288 37 1.7 53 2.3 153 6.9 156 6.9 643 28.8
30-34 1674 24 1.5 34 2.0 40 2.5 121 7.3 555 34.2
35+ 1055 27 2.6 30 2.9 10 1.0 63 6.0 419 40.5
Years since diagnosis 5-9 1132 5 0.4 22 1.9 76 6.8 49 4.4 196 17.7
10-14 3865 20 0.5 60 1.6 278 7.3 206 5.4 866 22.9
15-19 3665 38 1.1 57 1.6 244 6.8 198 5.4 910 25.5
20+ 2672 62 2.4 60 2.3 174 6.7 174 6.6 848 32.7
Age at diagnosis <1 898 3 0.3 9 1.0 54 6.1 23 2.6 123 13.9
1-4 3701 34 0.9 43 1.2 375 10.3 164 4.5 734 20.4
5-9 2388 25 1.1 36 1.5 259 11.1 149 6.3 595 25.6
10-14 2439 30 1.3 69 2.8 70 2.9 178 7.4 710 29.9
15-20 1908 33 1.8 42 2.2 14 0.8 113 6.0 658 35.4
Treatment Surgery only 1040 5 0.5 4 0.4 11 1.1 17 1.6 87 8.6
Chemotherapy, no radiation 3490 38 1.1 50 1.4 71 2.1 179 5.2 497 14.6
Radiation, no chemotherapy 971 10 1.1 14 1.5 128 13.9 46 4.8 409 43.7
Chemotherapy and radiation 4916 66 1.4 114 2.3 518 10.8 336 6.9 1630 34.2
Unknown 917 6 0.7 17 1.9 44 4.8 49 5.4 197 21.8
CCSS data from Dec2010 and March 2015 data freeze 1 N and % based on response of 'Yes' 2 'Any hormonal problem' is based on a response of 'Yes' to one or more of the listed hormonal problems
Hormonal systems: All leukemias 5
Overactive thyroid
(E.1/E.1) 1
Underactive thyroid
(E.2/E.2) 1
Thyroid nodules (E.3/E.3) 1
Thyroid enlargement
(E.4/E.4) 1
Diabetes- diet (E.5/E.5)
1
All cases N % N % N % N % N %
Both sexes All cases 7319 80 1.1 375 5.2 79 1.1 110 1.5 110 1.5
Age at baseline <18 2222 14 0.6 98 4.4 6 0.3 14 0.6 18 0.8
18-19 819 6 0.7 44 5.4 9 1.1 13 1.6 10 1.2
20-24 1817 19 1.1 99 5.5 20 1.1 25 1.4 19 1.0
25-29 1435 24 1.7 74 5.2 23 1.6 34 2.4 31 2.2
30-34 712 13 1.8 41 5.8 11 1.6 14 2.0 17 2.4
35+ 314 4 1.3 19 6.1 10 3.3 10 3.2 15 4.8
Years since diagnosis 5-9 977 4 0.4 15 1.5 5 0.5 8 0.8 7 0.7
10-14 2626 22 0.8 139 5.3 11 0.4 29 1.1 33 1.3
15-19 2232 30 1.4 115 5.2 24 1.1 33 1.5 33 1.5
20+ 1484 24 1.6 106 7.2 39 2.7 40 2.7 37 2.5
Age at diagnosis <1 226 2 0.9 29 12.9 3 1.3 2 0.9 9 4.0
1-4 3429 33 1.0 175 5.1 33 1.0 45 1.3 24 0.7
5-9 1806 17 0.9 79 4.4 16 0.9 30 1.7 26 1.4
10-14 1216 17 1.4 62 5.1 19 1.6 17 1.4 32 2.7
15-20 642 11 1.7 30 4.7 8 1.3 16 2.5 19 3.0
Treatment Surgery only 2 . . . . . . . . . .
Chemotherapy, no radiation 2929 17 0.6 111 3.8 15 0.5 29 1.0 33 1.1
Radiation, no chemotherapy 4 . . . . . . . . . .
Chemotherapy and radiation 3740 53 1.4 239 6.4 63 1.7 74 2.0 72 1.9
Unknown 644 10 1.6 25 3.9 1 0.2 7 1.1 5 0.8
Males All cases 3906 39 1.0 177 4.6 28 0.7 39 1.0 42 1.1
Age at baseline <18 1214 11 0.9 57 4.7 4 0.3 9 0.7 4 0.3
18-19 439 1 0.2 28 6.4 2 0.5 5 1.2 6 1.4
20-24 921 5 0.5 39 4.3 5 0.5 7 0.8 8 0.9
25-29 783 16 2.1 34 4.4 9 1.2 12 1.5 13 1.7
30-34 372 3 0.8 11 3.0 4 1.1 4 1.1 4 1.1
35+ 177 3 1.7 8 4.6 4 2.3 2 1.1 7 4.0
Years since diagnosis 5-9 556 2 0.4 8 1.4 2 0.4 4 0.7 1 0.2
10-14 1407 12 0.9 74 5.3 5 0.4 13 0.9 12 0.9
15-19 1153 12 1.0 47 4.1 7 0.6 12 1.0 14 1.2
20+ 790 13 1.7 48 6.1 14 1.8 10 1.3 15 1.9
Age at diagnosis <1 105 1 1.0 13 12.5 1 1.0 . . 5 4.8
1-4 1835 16 0.9 91 5.0 11 0.6 18 1.0 10 0.5
5-9 973 10 1.0 45 4.7 6 0.6 9 0.9 6 0.6
10-14 601 7 1.2 18 3.0 4 0.7 5 0.8 13 2.2
15-20 392 5 1.3 10 2.6 6 1.5 7 1.8 8 2.0
Treatment Surgery only 1 . . . . . . . . . .
Chemotherapy, no radiation 1459 8 0.6 47 3.2 5 0.3 8 0.6 15 1.0
Radiation, no chemotherapy 3 . . . . . . . . . .
Chemotherapy and radiation 2055 25 1.2 115 5.6 23 1.1 29 1.4 25 1.2
Unknown 388 6 1.6 15 3.9 . . 2 0.5 2 0.5
Females All cases 3413 41 1.2 198 5.8 51 1.5 71 2.1 68 2.0
Age at baseline <18 1008 3 0.3 41 4.1 2 0.2 5 0.5 14 1.4
18-19 380 5 1.3 16 4.3 7 1.9 8 2.1 4 1.1
20-24 896 14 1.6 60 6.8 15 1.7 18 2.0 11 1.2
CCSS data from Dec2010 and March 2015 data freeze 1 N and % based on response of 'Yes' 2 'Any hormonal problem' is based on a response of 'Yes' to one or more of the listed hormonal problems
Hormonal systems: All leukemias 6
Diabetes- pills
(E.6/E.6) 1
Diabetes- insulin
(E.7/E.7) 1
Growth hormone deficiency (E.8/E.8) 1
Osteoporosis (E.10/E.10) 1
Any hormonal problem2
All cases N % N % N % N % N %
Both sexes All cases 7319 74 1.0 194 2.7 502 7.0 429 5.9 1363 19.2
Age at baseline <18 2222 7 0.3 30 1.4 193 8.7 107 4.8 366 16.7
18-19 819 5 0.6 10 1.2 90 11.3 55 6.8 165 21.0
20-24 1817 10 0.6 46 2.5 120 6.8 102 5.6 319 18.2
25-29 1435 24 1.7 55 3.9 81 5.8 93 6.5 309 22.2
30-34 712 11 1.6 28 4.0 12 1.7 53 7.5 130 18.9
35+ 314 17 5.6 25 8.0 6 2.0 19 6.1 74 24.4
Years since diagnosis 5-9 977 2 0.2 34 3.5 44 4.6 52 5.4 141 14.7
10-14 2626 13 0.5 63 2.4 202 7.8 172 6.6 490 19.0
15-19 2232 21 1.0 48 2.2 157 7.3 128 5.8 398 18.5
20+ 1484 38 2.6 49 3.3 99 6.8 77 5.2 334 23.3
Age at diagnosis <1 226 3 1.4 8 3.6 34 15.2 15 6.7 61 27.4
1-4 3429 26 0.8 37 1.1 313 9.3 152 4.5 610 18.2
5-9 1806 14 0.8 32 1.8 118 6.7 111 6.2 302 17.3
10-14 1216 15 1.3 74 6.1 33 2.8 105 8.7 261 22.0
15-20 642 16 2.6 43 6.7 4 0.6 46 7.2 129 20.9
Treatment Surgery only 2 . . . . . . . . . .
Chemotherapy, no radiation 2929 24 0.8 61 2.1 73 2.5 178 6.1 406 14.1
Radiation, no chemotherapy 4 . . 1 25.0 . . 1 25.0 2 50.0
Chemotherapy and radiation 3740 44 1.2 120 3.2 380 10.5 225 6.1 854 23.7
Unknown 644 6 0.9 12 1.9 49 7.7 25 3.9 101 15.9
Males All cases 3906 31 0.8 92 2.4 325 8.5 207 5.3 701 18.4
Age at baseline <18 1214 2 0.2 14 1.2 133 11.0 69 5.7 229 19.1
18-19 439 3 0.7 6 1.4 61 14.3 32 7.4 97 22.8
20-24 921 5 0.6 21 2.3 72 8.0 49 5.3 156 17.4
25-29 783 9 1.2 24 3.1 50 6.5 37 4.7 142 18.6
30-34 372 4 1.1 14 3.8 7 1.9 12 3.2 43 11.9
35+ 177 8 4.7 13 7.4 2 1.2 8 4.6 34 19.9
Years since diagnosis 5-9 556 . . 18 3.2 31 5.6 29 5.2 87 15.8
10-14 1407 5 0.4 28 2.0 141 10.1 94 6.7 274 19.8
15-19 1153 10 0.9 22 1.9 93 8.4 55 4.8 187 16.8
20+ 790 16 2.1 24 3.1 60 7.7 29 3.7 153 19.9
Age at diagnosis <1 105 1 1.0 2 1.9 20 19.4 9 8.7 30 29.1
1-4 1835 12 0.7 19 1.0 205 11.3 86 4.7 341 18.9
5-9 973 4 0.4 15 1.5 76 8.0 60 6.2 167 17.7
10-14 601 8 1.4 30 5.0 20 3.4 34 5.7 99 16.7
15-20 392 6 1.6 26 6.6 4 1.1 18 4.6 64 16.9
Treatment Surgery only 1 . . . . . . . . . .
Chemotherapy, no radiation 1459 9 0.6 32 2.2 38 2.6 81 5.6 192 13.4
Radiation, no chemotherapy 3 . . . . . . 1 33.3 1 33.3
Chemotherapy and radiation 2055 18 0.9 55 2.7 247 12.4 112 5.5 446 22.4
Unknown 388 4 1.0 5 1.3 40 10.4 13 3.4 62 16.1
Females All cases 3413 43 1.3 102 3.0 177 5.3 222 6.6 662 20.1
Age at baseline <18 1008 5 0.5 16 1.6 60 6.0 38 3.8 137 13.8
18-19 380 2 0.5 4 1.1 29 7.9 23 6.1 68 18.8
20-24 896 5 0.6 25 2.8 48 5.5 53 6.0 163 19.0
CCSS data from Dec2010 and March 2015 data freeze 1 N and % based on response of 'Yes' 2 'Any hormonal problem' is based on a response of 'Yes' to one or more of the listed hormonal problems
Hormonal systems: All leukemias 7
Overactive thyroid
(E.1/E.1) 1
Underactive thyroid
(E.2/E.2) 1
Thyroid nodules (E.3/E.3) 1
Thyroid enlargement
(E.4/E.4) 1
Diabetes- diet (E.5/E.5)
1
All cases N % N % N % N % N %
25-29 652 8 1.2 40 6.1 14 2.2 22 3.4 18 2.8
30-34 340 10 3.0 30 8.8 7 2.1 10 2.9 13 3.8
35+ 137 1 0.7 11 8.1 6 4.5 8 5.9 8 5.9
Years since diagnosis 5-9 421 2 0.5 7 1.7 3 0.7 4 1.0 6 1.4
10-14 1219 10 0.8 65 5.4 6 0.5 16 1.3 21 1.7
15-19 1079 18 1.7 68 6.3 17 1.6 21 2.0 19 1.8
20+ 694 11 1.6 58 8.4 25 3.6 30 4.4 22 3.2
Age at diagnosis <1 121 1 0.8 16 13.3 2 1.7 2 1.7 4 3.3
1-4 1594 17 1.1 84 5.3 22 1.4 27 1.7 14 0.9
5-9 833 7 0.8 34 4.1 10 1.2 21 2.5 20 2.4
10-14 615 10 1.6 44 7.2 15 2.5 12 2.0 19 3.1
15-20 250 6 2.4 20 8.1 2 0.8 9 3.6 11 4.4
Treatment Surgery only 1 . . . . . . . . . .
Chemotherapy, no radiation 1470 9 0.6 64 4.4 10 0.7 21 1.4 18 1.2
Radiation, no chemotherapy 1 . . . . . . . . . .
Chemotherapy and radiation 1685 28 1.7 124 7.4 40 2.4 45 2.7 47 2.8
Unknown 256 4 1.6 10 3.9 1 0.4 5 2.0 3 1.2
CCSS data from Dec2010 and March 2015 data freeze 1 N and % based on response of 'Yes' 2 'Any hormonal problem' is based on a response of 'Yes' to one or more of the listed hormonal problems
Hormonal systems: All leukemias 8
Diabetes- pills
(E.6/E.6) 1
Diabetes- insulin
(E.7/E.7) 1
Growth hormone deficiency (E.8/E.8) 1
Osteoporosis (E.10/E.10) 1
Any hormonal problem2
All cases N % N % N % N % N %
25-29 652 15 2.3 31 4.8 31 4.9 56 8.6 167 26.4
30-34 340 7 2.1 14 4.1 5 1.5 41 12.2 87 26.8
35+ 137 9 6.8 12 8.8 4 3.0 11 8.1 40 30.3
Years since diagnosis 5-9 421 2 0.5 16 3.8 13 3.1 23 5.6 54 13.2
10-14 1219 8 0.7 35 2.9 61 5.1 78 6.4 216 18.1
15-19 1079 11 1.1 26 2.4 64 6.2 73 6.8 211 20.4
20+ 694 22 3.2 25 3.6 39 5.8 48 7.0 181 27.2
Age at diagnosis <1 121 2 1.7 6 5.0 14 11.7 6 5.0 31 25.8
1-4 1594 14 0.9 18 1.1 108 6.9 66 4.2 269 17.4
5-9 833 10 1.2 17 2.1 42 5.2 51 6.2 135 16.8
10-14 615 7 1.2 44 7.2 13 2.2 71 11.7 162 27.3
15-20 250 10 4.2 17 6.9 . . 28 11.3 65 27.1
Treatment Surgery only 1 . . . . . . . . . .
Chemotherapy, no radiation 1470 15 1.0 29 2.0 35 2.4 97 6.6 214 14.9
Radiation, no chemotherapy 1 . . 1 . . . . . 1 .
Chemotherapy and radiation 1685 26 1.6 65 3.9 133 8.2 113 6.8 408 25.4
Unknown 256 2 0.8 7 2.8 9 3.6 12 4.7 39 15.6
CCSS data from Dec2010 and March 2015 data freeze 1 N and % based on response of 'Yes' 2 'Any hormonal problem' is based on a response of 'Yes' to one or more of the listed hormonal problems
Hormonal systems: ALL 9
Overactive thyroid
(E.1/E.1) 1
Underactive thyroid
(E.2/E.2) 1
Thyroid nodules (E.3/E.3) 1
Thyroid enlargement
(E.4/E.4) 1
Diabetes- diet (E.5/E.5)
1
All cases N % N % N % N % N %
Both sexes All cases 6148 61 1.0 245 4.0 45 0.7 82 1.3 78 1.3
Age at baseline <18 1932 10 0.5 61 3.2 4 0.2 12 0.6 16 0.8
18-19 706 5 0.7 27 3.9 5 0.7 9 1.3 6 0.9
20-24 1555 13 0.8 68 4.4 9 0.6 19 1.2 13 0.8
25-29 1188 20 1.7 46 3.9 12 1.0 21 1.8 20 1.7
30-34 545 10 1.8 30 5.5 9 1.7 12 2.2 12 2.2
35+ 222 3 1.4 13 5.9 6 2.7 9 4.1 11 5.0
Years since diagnosis 5-9 842 4 0.5 11 1.3 3 0.4 6 0.7 7 0.8
10-14 2214 16 0.7 79 3.6 3 0.1 19 0.9 27 1.2
15-19 1851 21 1.1 79 4.3 13 0.7 26 1.4 19 1.0
20+ 1241 20 1.6 76 6.2 26 2.1 31 2.5 25 2.0
Age at diagnosis <1 121 1 0.8 14 11.7 2 1.7 2 1.7 7 5.8
1-4 3043 25 0.8 125 4.1 22 0.7 35 1.2 14 0.5
5-9 1588 13 0.8 50 3.2 7 0.4 21 1.3 20 1.3
10-14 956 14 1.5 38 4.0 10 1.1 12 1.3 22 2.3
15-20 440 8 1.8 18 4.1 4 0.9 12 2.7 15 3.4
Treatment Chemotherapy, no radiation 2300 11 0.5 57 2.5 5 0.2 19 0.8 22 1.0
Radiation, no chemotherapy 3 . . . . . . . . . .
Chemotherapy and radiation 3283 42 1.3 168 5.2 39 1.2 58 1.8 55 1.7
Unknown 562 8 1.4 20 3.6 1 0.2 5 0.9 1 0.2
Males All cases 3308 32 1.0 120 3.6 17 0.5 30 0.9 25 0.8
Age at baseline <18 1057 8 0.8 37 3.5 2 0.2 7 0.7 2 0.2
18-19 382 1 0.3 16 4.2 1 0.3 3 0.8 4 1.0
20-24 789 5 0.6 31 3.9 3 0.4 7 0.9 6 0.8
25-29 660 13 2.0 23 3.5 6 0.9 8 1.2 7 1.1
30-34 290 2 0.7 6 2.1 3 1.0 3 1.0 2 0.7
35+ 130 3 2.3 7 5.4 2 1.6 2 1.6 4 3.1
Years since diagnosis 5-9 480 2 0.4 6 1.3 1 0.2 2 0.4 1 0.2
10-14 1195 10 0.8 46 3.9 2 0.2 8 0.7 8 0.7
15-19 969 10 1.0 33 3.4 2 0.2 11 1.1 7 0.7
20+ 664 10 1.5 35 5.3 12 1.8 9 1.4 9 1.4
Age at diagnosis <1 59 1 1.7 7 11.9 . . . . 3 5.1
1-4 1623 13 0.8 62 3.8 8 0.5 16 1.0 5 0.3
5-9 864 7 0.8 34 4.0 5 0.6 6 0.7 5 0.6
10-14 487 6 1.2 11 2.3 2 0.4 4 0.8 8 1.7
15-20 275 5 1.8 6 2.2 2 0.7 4 1.5 4 1.5
Treatment Chemotherapy, no radiation 1142 6 0.5 24 2.1 4 0.4 5 0.4 8 0.7
Radiation, no chemotherapy 2 . . . . . . . . . .
Chemotherapy and radiation 1823 22 1.2 84 4.6 13 0.7 24 1.3 16 0.9
Unknown 341 4 1.2 12 3.5 . . 1 0.3 1 0.3
Females All cases 2840 29 1.0 125 4.4 28 1.0 52 1.8 53 1.9
Age at baseline <18 875 2 0.2 24 2.7 2 0.2 5 0.6 14 1.6
18-19 324 4 1.2 11 3.4 4 1.3 6 1.9 2 0.6
20-24 766 8 1.1 37 4.9 6 0.8 12 1.6 7 0.9
25-29 528 7 1.3 23 4.4 6 1.1 13 2.5 13 2.5
30-34 255 8 3.2 24 9.4 6 2.4 9 3.5 10 3.9
CCSS data from Dec2010 and March 2015 data freeze 1 N and % based on response of 'Yes' 2 'Any hormonal problem' is based on a response of 'Yes' to one or more of the listed hormonal problems
Hormonal systems: ALL 10
Diabetes- pills
(E.6/E.6) 1
Diabetes- insulin
(E.7/E.7) 1
Growth hormone deficiency (E.8/E.8) 1
Osteoporosis (E.10/E.10) 1
Any hormonal problem2
All cases N % N % N % N % N %
Both sexes All cases 6148 47 0.8 155 2.5 382 6.4 327 5.3 1027 17.2
Age at baseline <18 1932 4 0.2 24 1.2 149 7.8 95 4.9 288 15.1
18-19 706 3 0.4 7 1.0 74 10.8 45 6.4 130 19.2
20-24 1555 6 0.4 36 2.3 88 5.9 81 5.2 242 16.2
25-29 1188 16 1.4 45 3.8 61 5.3 68 5.7 227 19.7
30-34 545 9 1.7 25 4.6 9 1.7 31 5.7 92 17.6
35+ 222 9 4.1 18 8.1 1 0.5 7 3.2 48 22.0
Years since diagnosis 5-9 842 2 0.2 30 3.6 38 4.5 46 5.5 120 14.5
10-14 2214 9 0.4 50 2.3 144 6.6 131 5.9 357 16.4
15-19 1851 13 0.7 38 2.1 121 6.8 101 5.5 302 17.0
20+ 1241 23 1.9 37 3.0 79 6.5 49 4.0 248 20.6
Age at diagnosis <1 121 1 0.8 6 5.0 23 19.2 9 7.4 35 29.2
1-4 3043 17 0.6 26 0.9 259 8.7 132 4.4 491 16.6
5-9 1588 7 0.5 25 1.6 82 5.3 92 5.8 232 15.1
10-14 956 12 1.3 64 6.7 15 1.6 68 7.2 183 19.6
15-20 440 10 2.3 34 7.7 3 0.7 26 5.9 86 20.1
Treatment Chemotherapy, no radiation 2300 16 0.7 42 1.8 37 1.6 139 6.1 271 12.0
Radiation, no chemotherapy 3 . . 1 33.3 . . 1 33.3 2 66.7
Chemotherapy and radiation 3283 29 0.9 103 3.2 303 9.6 168 5.1 670 21.2
Unknown 562 2 0.4 9 1.6 42 7.6 19 3.4 84 15.1
Males All cases 3308 19 0.6 71 2.2 261 8.1 171 5.2 551 17.1
Age at baseline <18 1057 . . 9 0.9 102 9.7 58 5.5 179 17.1
18-19 382 3 0.8 6 1.6 53 14.3 27 7.1 78 21.1
20-24 789 4 0.5 16 2.0 60 7.9 41 5.2 127 16.6
25-29 660 4 0.6 19 2.9 40 6.2 33 5.0 111 17.3
30-34 290 4 1.4 12 4.2 5 1.8 9 3.1 33 11.7
35+ 130 4 3.1 9 7.0 1 0.8 3 2.3 23 18.1
Years since diagnosis 5-9 480 . . 17 3.5 26 5.4 25 5.2 72 15.1
10-14 1195 3 0.3 20 1.7 107 9.1 78 6.6 210 17.9
15-19 969 6 0.6 17 1.8 77 8.3 47 4.9 151 16.2
20+ 664 10 1.5 17 2.6 51 7.8 21 3.2 118 18.2
Age at diagnosis <1 59 . . 1 1.7 13 22.4 4 6.8 17 29.3
1-4 1623 8 0.5 12 0.7 171 10.7 75 4.6 275 17.3
5-9 864 2 0.2 12 1.4 63 7.5 54 6.3 140 16.8
10-14 487 7 1.5 26 5.4 11 2.3 24 5.0 74 15.4
15-20 275 2 0.7 20 7.3 3 1.1 14 5.1 45 16.8
Treatment Chemotherapy, no radiation 1142 6 0.5 20 1.8 21 1.9 68 6.0 131 11.7
Radiation, no chemotherapy 2 . . . . . . 1 50.0 1 50.0
Chemotherapy and radiation 1823 11 0.6 46 2.5 205 11.6 92 5.1 366 20.7
Unknown 341 2 0.6 5 1.5 35 10.4 10 2.9 53 15.7
Females All cases 2840 28 1.0 84 3.0 121 4.4 156 5.5 476 17.3
Age at baseline <18 875 4 0.5 15 1.7 47 5.4 37 4.2 109 12.6
18-19 324 . . 1 0.3 21 6.7 18 5.6 52 16.9
20-24 766 2 0.3 20 2.6 28 3.8 40 5.3 115 15.8
25-29 528 12 2.3 26 4.9 21 4.1 35 6.6 116 22.7
30-34 255 5 2.1 13 5.1 4 1.7 22 8.8 59 24.5
CCSS data from Dec2010 and March 2015 data freeze 1 N and % based on response of 'Yes' 2 'Any hormonal problem' is based on a response of 'Yes' to one or more of the listed hormonal problems
Hormonal systems: ALL 11
Overactive thyroid
(E.1/E.1) 1
Underactive thyroid
(E.2/E.2) 1
Thyroid nodules (E.3/E.3) 1
Thyroid enlargement
(E.4/E.4) 1
Diabetes- diet (E.5/E.5)
1
All cases N % N % N % N % N %
35+ 92 . . 6 6.6 4 4.4 7 7.7 7 7.6
Years since diagnosis 5-9 362 2 0.6 5 1.4 2 0.6 4 1.1 6 1.7
10-14 1019 6 0.6 33 3.3 1 0.1 11 1.1 19 1.9
15-19 882 11 1.3 46 5.3 11 1.3 15 1.7 12 1.4
20+ 577 10 1.7 41 7.1 14 2.4 22 3.8 16 2.8
Age at diagnosis <1 62 . . 7 11.5 2 3.3 2 3.3 4 6.6
1-4 1420 12 0.8 63 4.5 14 1.0 19 1.3 9 0.6
5-9 724 6 0.8 16 2.2 2 0.3 15 2.1 15 2.1
10-14 469 8 1.7 27 5.8 8 1.7 8 1.7 14 3.0
15-20 165 3 1.8 12 7.3 2 1.2 8 4.9 11 6.7
Treatment Chemotherapy, no radiation 1158 5 0.4 33 2.9 1 0.1 14 1.2 14 1.2
Radiation, no chemotherapy 1 . . . . . . . . . .
Chemotherapy and radiation 1460 20 1.4 84 5.8 26 1.8 34 2.3 39 2.7
Unknown 221 4 1.8 8 3.6 1 0.5 4 1.8 . .
CCSS data from Dec2010 and March 2015 data freeze 1 N and % based on response of 'Yes' 2 'Any hormonal problem' is based on a response of 'Yes' to one or more of the listed hormonal problems
Hormonal systems: ALL 12
Diabetes- pills
(E.6/E.6) 1
Diabetes- insulin
(E.7/E.7) 1
Growth hormone deficiency (E.8/E.8) 1
Osteoporosis (E.10/E.10) 1
Any hormonal problem2
All cases N % N % N % N % N %
35+ 92 5 5.5 9 9.8 . . 4 4.3 25 27.5
Years since diagnosis 5-9 362 2 0.6 13 3.6 12 3.3 21 5.9 48 13.6
10-14 1019 6 0.6 30 2.9 37 3.7 53 5.2 147 14.8
15-19 882 7 0.8 21 2.4 44 5.2 54 6.1 151 17.9
20+ 577 13 2.3 20 3.5 28 5.0 28 4.9 130 23.4
Age at diagnosis <1 62 1 1.6 5 8.2 10 16.1 5 8.1 18 29.0
1-4 1420 9 0.6 14 1.0 88 6.3 57 4.0 216 15.7
5-9 724 5 0.7 13 1.8 19 2.7 38 5.3 92 13.2
10-14 469 5 1.1 38 8.1 4 0.9 44 9.5 109 24.1
15-20 165 8 5.0 14 8.5 . . 12 7.3 41 25.8
Treatment Chemotherapy, no radiation 1158 10 0.9 22 1.9 16 1.4 71 6.2 140 12.3
Radiation, no chemotherapy 1 . . 1 . . . . . 1 .
Chemotherapy and radiation 1460 18 1.3 57 3.9 98 7.0 76 5.2 304 21.9
Unknown 221 . . 4 1.8 7 3.2 9 4.1 31 14.3
CCSS data from Dec2010 and March 2015 data freeze 1 N and % based on response of 'Yes' 2 'Any hormonal problem' is based on a response of 'Yes' to one or more of the listed hormonal problems
Hormonal systems: AML 13
Overactive thyroid
(E.1/E.1) 1
Underactive thyroid
(E.2/E.2) 1
Thyroid nodules (E.3/E.3) 1
Thyroid enlargement
(E.4/E.4) 1
Diabetes- diet (E.5/E.5)
1
All cases N % N % N % N % N %
Both sexes All cases 868 18 2.1 101 11.8 24 2.8 18 2.1 21 2.4
Age at baseline <18 227 4 1.8 27 12.0 2 0.9 2 0.9 2 0.9
18-19 89 1 1.2 13 15.1 3 3.5 3 3.5 3 3.5
20-24 187 6 3.2 28 15.1 9 4.8 4 2.1 5 2.7
25-29 181 3 1.7 18 9.9 6 3.3 7 3.9 5 2.8
30-34 123 3 2.4 9 7.3 2 1.6 2 1.6 4 3.3
35+ 61 1 1.7 6 10.2 2 3.5 . . 2 3.4
Years since diagnosis 5-9 84 . . 4 4.9 2 2.4 1 1.2 . .
10-14 318 6 1.9 42 13.4 6 1.9 8 2.5 2 0.6
15-19 297 8 2.7 30 10.1 10 3.4 5 1.7 12 4.1
20+ 169 4 2.4 25 15.0 6 3.7 4 2.4 7 4.2
Age at diagnosis <1 90 1 1.1 13 14.6 1 1.1 . . 2 2.2
1-4 294 8 2.7 39 13.4 8 2.7 7 2.4 9 3.1
5-9 160 4 2.5 20 12.7 6 3.8 6 3.8 3 1.9
10-14 183 2 1.1 18 9.9 6 3.4 2 1.1 4 2.2
15-20 141 3 2.1 11 7.9 3 2.2 3 2.1 3 2.1
Treatment Surgery only 2 . . . . . . . . . .
Chemotherapy, no radiation 525 6 1.2 46 8.8 9 1.7 10 1.9 8 1.5
Radiation, no chemotherapy 1 . . . . . . . . . .
Chemotherapy and radiation 285 10 3.5 51 18.1 15 5.3 6 2.1 11 3.9
Unknown 55 2 3.6 4 7.3 . . 2 3.7 2 3.7
Males All cases 429 6 1.4 45 10.6 9 2.1 6 1.4 10 2.4
Age at baseline <18 123 3 2.5 15 12.3 2 1.6 2 1.6 2 1.6
18-19 45 . . 10 23.3 1 2.3 1 2.3 1 2.3
20-24 90 . . 8 8.9 2 2.2 . . 2 2.2
25-29 81 2 2.5 6 7.4 2 2.5 2 2.5 1 1.3
30-34 60 1 1.7 5 8.3 1 1.7 1 1.7 2 3.4
35+ 30 . . 1 3.4 1 3.6 . . 2 6.9
Years since diagnosis 5-9 50 . . 2 4.1 1 2.0 1 2.0 . .
10-14 158 2 1.3 20 12.7 2 1.3 3 1.9 1 0.6
15-19 138 1 0.7 11 8.0 5 3.6 1 0.7 5 3.6
20+ 83 3 3.7 12 14.6 1 1.3 1 1.2 4 5.0
Age at diagnosis <1 38 . . 5 13.5 1 2.7 . . 2 5.4
1-4 160 3 1.9 24 15.1 3 1.9 2 1.3 4 2.5
5-9 74 3 4.1 8 11.0 1 1.4 2 2.7 . .
10-14 77 . . 4 5.3 1 1.3 . . 1 1.3
15-20 80 . . 4 5.0 3 3.8 2 2.5 3 3.8
Treatment Surgery only 1 . . . . . . . . . .
Chemotherapy, no radiation 253 2 0.8 22 8.8 1 0.4 3 1.2 4 1.6
Radiation, no chemotherapy 1 . . . . . . . . . .
Chemotherapy and radiation 143 2 1.4 21 14.9 8 5.7 2 1.4 6 4.3
Unknown 31 2 6.5 2 6.5 . . 1 3.3 . .
Females All cases 439 12 2.8 56 12.9 15 3.4 12 2.7 11 2.5
Age at baseline <18 104 1 1.0 12 11.7 . . . . . .
18-19 44 1 2.3 3 7.0 2 4.7 2 4.7 2 4.7
20-24 97 6 6.2 20 21.1 7 7.2 4 4.1 3 3.1
CCSS data from Dec2010 and March 2015 data freeze 1 N and % based on response of 'Yes' 2 'Any hormonal problem' is based on a response of 'Yes' to one or more of the listed hormonal problems
Hormonal systems: AML 14
Diabetes- pills
(E.6/E.6) 1
Diabetes- insulin
(E.7/E.7) 1
Growth hormone deficiency (E.8/E.8) 1
Osteoporosis (E.10/E.10) 1
Any hormonal problem2
All cases N % N % N % N % N %
Both sexes All cases 868 20 2.4 23 2.7 87 10.2 70 8.1 237 28.0
Age at baseline <18 227 3 1.3 5 2.2 30 13.4 11 4.9 59 26.5
18-19 89 2 2.4 1 1.2 14 16.3 8 9.3 28 32.9
20-24 187 4 2.1 7 3.8 24 12.8 13 7.0 57 30.6
25-29 181 7 4.0 5 2.8 14 8.0 17 9.4 52 29.5
30-34 123 . . 1 0.8 2 1.6 13 10.6 25 20.5
35+ 61 4 7.1 4 6.8 3 5.3 8 13.6 16 29.1
Years since diagnosis 5-9 84 . . . . 3 3.8 5 6.0 13 16.7
10-14 318 4 1.3 10 3.2 40 12.8 31 9.8 95 30.4
15-19 297 8 2.7 7 2.4 31 10.5 15 5.1 73 24.8
20+ 169 8 4.9 6 3.6 13 7.9 19 11.4 56 34.6
Age at diagnosis <1 90 2 2.2 1 1.1 9 10.2 5 5.7 22 25.0
1-4 294 8 2.7 9 3.1 41 14.1 16 5.5 89 30.8
5-9 160 5 3.1 5 3.1 25 15.6 13 8.1 51 32.1
10-14 183 1 0.6 3 1.7 11 6.1 24 13.3 47 26.4
15-20 141 4 3.0 5 3.6 1 0.8 12 8.6 28 21.1
Treatment Surgery only 2 . . . . . . . . . .
Chemotherapy, no radiation 525 7 1.4 11 2.1 28 5.4 29 5.6 108 21.0
Radiation, no chemotherapy 1 . . . . . . . . . .
Chemotherapy and radiation 285 11 4.0 11 3.9 55 19.9 37 13.2 118 42.9
Unknown 55 2 3.7 1 1.9 4 7.4 4 7.3 11 20.4
Males All cases 429 11 2.6 10 2.4 44 10.4 30 7.0 108 25.7
Age at baseline <18 123 2 1.6 4 3.3 20 16.3 10 8.1 39 32.0
18-19 45 . . . . 7 16.3 5 11.4 17 39.5
20-24 90 1 1.1 2 2.2 8 8.9 6 6.7 21 23.3
25-29 81 5 6.3 1 1.2 7 8.9 4 5.0 17 21.5
30-34 60 . . 1 1.7 2 3.3 2 3.3 8 13.3
35+ 30 3 11.1 2 6.9 . . 3 10.3 6 22.2
Years since diagnosis 5-9 50 . . . . 3 6.1 4 8.0 11 22.9
10-14 158 2 1.3 5 3.2 22 14.1 14 8.9 45 28.8
15-19 138 4 2.9 2 1.5 13 9.5 5 3.6 27 19.7
20+ 83 5 6.3 3 3.7 6 7.4 7 8.6 25 31.3
Age at diagnosis <1 38 1 2.7 . . 5 13.5 4 11.1 10 27.0
1-4 160 4 2.5 5 3.1 23 14.4 10 6.3 52 32.5
5-9 74 2 2.7 1 1.4 10 13.5 5 6.8 21 28.8
10-14 77 1 1.4 1 1.3 5 6.7 9 11.8 13 17.3
15-20 80 3 3.9 3 3.8 1 1.3 2 2.5 12 15.8
Treatment Surgery only 1 . . . . . . . . . .
Chemotherapy, no radiation 253 3 1.2 6 2.4 13 5.2 10 4.0 49 19.6
Radiation, no chemotherapy 1 . . . . . . . . . .
Chemotherapy and radiation 143 7 5.0 4 2.8 28 20.1 17 12.1 53 38.4
Unknown 31 1 3.3 . . 3 9.7 3 9.7 6 19.4
Females All cases 439 9 2.1 13 3.0 43 10.0 40 9.2 129 30.3
Age at baseline <18 104 1 1.0 1 1.0 10 9.9 1 1.0 20 19.8
18-19 44 2 4.7 1 2.3 7 16.3 3 7.1 11 26.2
20-24 97 3 3.1 5 5.3 16 16.5 7 7.2 36 37.5
CCSS data from Dec2010 and March 2015 data freeze 1 N and % based on response of 'Yes' 2 'Any hormonal problem' is based on a response of 'Yes' to one or more of the listed hormonal problems
Hormonal systems: AML 15
Overactive thyroid
(E.1/E.1) 1
Underactive thyroid
(E.2/E.2) 1
Thyroid nodules (E.3/E.3) 1
Thyroid enlargement
(E.4/E.4) 1
Diabetes- diet (E.5/E.5)
1
All cases N % N % N % N % N %
25-29 100 1 1.0 12 12.0 4 4.0 5 5.0 4 4.0
30-34 63 2 3.2 4 6.3 1 1.6 1 1.6 2 3.2
35+ 31 1 3.3 5 16.7 1 3.4 . . . .
Years since diagnosis 5-9 34 . . 2 6.1 1 3.0 . . . .
10-14 160 4 2.5 22 14.0 4 2.5 5 3.1 1 0.6
15-19 159 7 4.4 19 11.9 5 3.1 4 2.5 7 4.4
20+ 86 1 1.2 13 15.3 5 6.0 3 3.5 3 3.5
Age at diagnosis <1 52 1 1.9 8 15.4 . . . . . .
1-4 134 5 3.8 15 11.3 5 3.7 5 3.7 5 3.8
5-9 86 1 1.2 12 14.3 5 5.8 4 4.7 3 3.5
10-14 106 2 1.9 14 13.3 5 4.8 2 1.9 3 2.9
15-20 61 3 5.0 7 11.7 . . 1 1.7 . .
Treatment Surgery only 1 . . . . . . . . . .
Chemotherapy, no radiation 272 4 1.5 24 8.9 8 3.0 7 2.6 4 1.5
Chemotherapy and radiation 142 8 5.7 30 21.4 7 5.0 4 2.8 5 3.5
Unknown 24 . . 2 8.3 . . 1 4.2 2 8.3
CCSS data from Dec2010 and March 2015 data freeze 1 N and % based on response of 'Yes' 2 'Any hormonal problem' is based on a response of 'Yes' to one or more of the listed hormonal problems
Hormonal systems: AML 16
Diabetes- pills
(E.6/E.6) 1
Diabetes- insulin
(E.7/E.7) 1
Growth hormone deficiency (E.8/E.8) 1
Osteoporosis (E.10/E.10) 1
Any hormonal problem2
All cases N % N % N % N % N %
25-29 100 2 2.1 4 4.0 7 7.3 13 13.0 35 36.1
30-34 63 . . . . . . 11 17.5 17 27.4
35+ 31 1 3.4 2 6.7 3 10.3 5 16.7 10 35.7
Years since diagnosis 5-9 34 . . . . . . 1 3.0 2 6.7
10-14 160 2 1.3 5 3.2 18 11.5 17 10.8 50 31.8
15-19 159 4 2.5 5 3.2 18 11.3 10 6.3 46 29.3
20+ 86 3 3.6 3 3.5 7 8.4 12 14.1 31 37.8
Age at diagnosis <1 52 1 1.9 1 1.9 4 7.8 1 1.9 12 23.5
1-4 134 4 3.0 4 3.0 18 13.7 6 4.6 37 28.7
5-9 86 3 3.5 4 4.7 15 17.4 8 9.3 30 34.9
10-14 106 . . 2 1.9 6 5.7 15 14.3 34 33.0
15-20 61 1 1.8 2 3.4 . . 10 16.7 16 28.1
Treatment Surgery only 1 . . . . . . . . . .
Chemotherapy, no radiation 272 4 1.5 5 1.9 15 5.6 19 7.1 59 22.3
Chemotherapy and radiation 142 4 2.9 7 5.0 27 19.7 20 14.3 65 47.4
Unknown 24 1 4.2 1 4.2 1 4.3 1 4.2 5 21.7
CCSS data from Dec2010 and March 2015 data freeze 1 N and % based on response of 'Yes' 2 'Any hormonal problem' is based on a response of 'Yes' to one or more of the listed hormonal problems
Hormonal systems: All CNS 17
Overactive thyroid
(E.1/E.1) 1
Underactive thyroid
(E.2/E.2) 1
Thyroid nodules (E.3/E.3) 1
Thyroid enlargement
(E.4/E.4) 1
Diabetes- diet (E.5/E.5)
1
All cases N % N % N % N % N %
Both sexes All cases 4325 108 2.5 823 19.3 73 1.7 80 1.9 39 0.9
Age at baseline <18 948 16 1.7 191 20.3 8 0.9 6 0.6 6 0.6
18-19 371 8 2.2 72 19.6 7 1.9 6 1.6 1 0.3
20-24 1136 29 2.6 237 21.1 15 1.3 22 2.0 6 0.5
25-29 1037 31 3.0 190 18.6 22 2.2 24 2.3 10 1.0
30-34 584 17 2.9 100 17.2 14 2.4 13 2.2 8 1.4
35+ 249 7 2.9 33 13.5 7 2.9 9 3.7 8 3.3
Years since diagnosis 5-9 461 9 2.0 91 19.9 1 0.2 1 0.2 3 0.7
10-14 1536 33 2.2 293 19.2 18 1.2 20 1.3 13 0.9
15-19 1349 33 2.5 255 19.2 27 2.0 30 2.3 5 0.4
20+ 979 33 3.5 184 19.1 27 2.8 29 3.0 18 1.9
Age at diagnosis <1 209 2 1.0 39 18.9 1 0.5 1 0.5 2 1.0
1-4 1275 32 2.6 247 19.6 22 1.8 23 1.8 6 0.5
5-9 1349 32 2.4 301 22.7 29 2.2 26 1.9 10 0.7
10-14 1031 35 3.4 182 17.8 13 1.3 21 2.1 14 1.4
15-20 461 7 1.5 54 11.8 8 1.8 9 2.0 7 1.5
Treatment Surgery only 1221 19 1.6 59 4.9 8 0.7 15 1.2 10 0.8
Chemotherapy, no radiation 317 9 2.9 44 14.0 2 0.6 5 1.6 6 1.9
Radiation, no chemotherapy 1133 19 1.7 202 18.1 22 2.0 24 2.2 8 0.7
Chemotherapy and radiation 1262 51 4.1 465 37.5 38 3.1 33 2.7 12 1.0
Unknown 392 10 2.6 53 13.7 3 0.8 3 0.8 3 0.8
Males All cases 2360 62 2.7 466 19.9 27 1.2 28 1.2 16 0.7
Age at baseline <18 527 13 2.5 117 22.3 4 0.8 3 0.6 5 1.0
18-19 188 4 2.1 36 19.3 4 2.1 3 1.6 1 0.5
20-24 610 16 2.7 141 23.4 5 0.8 8 1.3 1 0.2
25-29 595 21 3.6 105 17.9 5 0.9 8 1.4 2 0.3
30-34 308 5 1.6 54 17.6 3 1.0 2 0.7 4 1.3
35+ 132 3 2.3 13 10.0 6 4.7 4 3.1 3 2.3
Years since diagnosis 5-9 262 4 1.5 57 21.9 . . 1 0.4 2 0.8
10-14 830 24 2.9 174 21.0 7 0.8 5 0.6 7 0.8
15-19 736 17 2.3 140 19.3 12 1.7 13 1.8 1 0.1
20+ 532 17 3.3 95 18.1 8 1.5 9 1.7 6 1.1
Age at diagnosis <1 120 1 0.8 27 22.9 1 0.8 1 0.9 1 0.8
1-4 677 23 3.4 137 20.4 10 1.5 11 1.6 2 0.3
5-9 755 18 2.4 175 23.5 7 0.9 9 1.2 6 0.8
10-14 553 18 3.3 103 18.7 3 0.5 3 0.5 3 0.5
15-20 255 2 0.8 24 9.5 6 2.4 4 1.6 4 1.6
Treatment Surgery only 625 9 1.4 25 4.0 1 0.2 2 0.3 4 0.6
Chemotherapy, no radiation 169 8 4.8 27 16.2 . . 2 1.2 3 1.8
Radiation, no chemotherapy 593 10 1.7 105 17.9 12 2.1 10 1.7 2 0.3
Chemotherapy and radiation 755 28 3.8 283 38.0 14 1.9 12 1.6 6 0.8
Unknown 218 7 3.2 26 12.0 . . 2 0.9 1 0.5
Females All cases 1965 46 2.4 357 18.4 46 2.4 52 2.7 23 1.2
Age at baseline <18 421 3 0.7 74 17.9 4 1.0 3 0.7 1 0.2
18-19 183 4 2.2 36 19.9 3 1.7 3 1.7 . .
20-24 526 13 2.5 96 18.5 10 1.9 14 2.7 5 1.0
CCSS data from Dec2010 and March 2015 data freeze 1 N and % based on response of 'Yes' 2 'Any hormonal problem' is based on a response of 'Yes' to one or more of the listed hormonal problems
Hormonal systems: All CNS 18
Diabetes- pills
(E.6/E.6) 1
Diabetes- insulin
(E.7/E.7) 1
Growth hormone deficiency (E.8/E.8) 1
Osteoporosis (E.10/E.10) 1
Any hormonal problem2
All cases N % N % N % N % N %
Both sexes All cases 4325 52 1.2 33 0.8 951 22.5 256 6.0 1500 35.6
Age at baseline <18 948 5 0.5 8 0.9 304 32.4 45 4.8 386 41.5
18-19 371 2 0.6 2 0.5 104 29.1 26 7.0 137 38.5
20-24 1136 11 1.0 8 0.7 272 24.5 78 7.0 407 36.6
25-29 1037 19 1.9 6 0.6 198 19.6 65 6.3 348 34.4
30-34 584 8 1.4 3 0.5 63 11.1 31 5.3 161 28.5
35+ 249 7 2.9 6 2.4 10 4.1 11 4.5 61 25.2
Years since diagnosis 5-9 461 3 0.7 4 0.9 126 27.9 24 5.2 172 38.4
10-14 1536 10 0.7 8 0.5 344 22.9 96 6.3 536 35.7
15-19 1349 13 1.0 11 0.8 298 22.5 72 5.4 457 34.7
20+ 979 26 2.7 10 1.0 183 19.1 64 6.6 335 35.4
Age at diagnosis <1 209 1 0.5 1 0.5 53 25.7 13 6.3 73 35.8
1-4 1275 14 1.1 7 0.6 377 30.2 68 5.4 498 40.1
5-9 1349 16 1.2 13 1.0 366 27.8 93 7.0 524 39.9
10-14 1031 12 1.2 5 0.5 135 13.3 62 6.1 315 31.0
15-20 461 9 2.0 7 1.5 20 4.5 20 4.4 90 20.4
Treatment Surgery only 1221 7 0.6 6 0.5 29 2.4 28 2.3 132 11.1
Chemotherapy, no radiation 317 5 1.6 1 0.3 42 13.5 9 2.9 81 26.1
Radiation, no chemotherapy 1133 14 1.3 8 0.7 262 23.9 66 5.9 416 38.1
Chemotherapy and radiation 1262 22 1.8 14 1.1 550 44.6 135 10.9 756 61.4
Unknown 392 4 1.0 4 1.0 68 17.5 18 4.6 115 29.6
Males All cases 2360 18 0.8 9 0.4 572 24.7 124 5.3 827 36.0
Age at baseline <18 527 3 0.6 2 0.4 178 34.0 21 4.0 228 43.8
18-19 188 . . 1 0.5 58 32.2 15 8.0 73 40.6
20-24 610 2 0.3 2 0.3 172 28.8 40 6.6 235 39.4
25-29 595 8 1.4 2 0.3 117 20.0 31 5.3 185 31.9
30-34 308 4 1.3 1 0.3 39 13.1 13 4.3 79 27.0
35+ 132 1 0.8 1 0.8 8 6.2 4 3.1 27 21.3
Years since diagnosis 5-9 262 2 0.8 1 0.4 79 31.1 15 5.7 108 42.7
10-14 830 4 0.5 3 0.4 202 24.8 47 5.7 302 37.1
15-19 736 3 0.4 2 0.3 183 25.3 36 5.0 255 35.5
20+ 532 9 1.7 3 0.6 108 20.7 26 4.9 162 31.6
Age at diagnosis <1 120 1 0.8 . . 29 24.4 6 5.1 41 35.0
1-4 677 4 0.6 1 0.1 229 34.4 26 3.9 279 42.0
5-9 755 8 1.1 5 0.7 210 28.3 53 7.1 296 40.3
10-14 553 1 0.2 1 0.2 94 17.2 30 5.5 169 31.1
15-20 255 4 1.7 2 0.8 10 4.2 9 3.6 42 17.6
Treatment Surgery only 625 3 0.5 3 0.5 19 3.1 14 2.3 62 10.2
Chemotherapy, no radiation 169 2 1.2 . . 21 12.5 2 1.2 44 26.5
Radiation, no chemotherapy 593 4 0.7 2 0.3 142 24.7 29 4.9 217 38.1
Chemotherapy and radiation 755 6 0.8 3 0.4 345 46.5 75 10.1 443 60.0
Unknown 218 3 1.4 1 0.5 45 20.8 4 1.8 61 28.2
Females All cases 1965 34 1.8 24 1.2 379 19.7 132 6.8 673 35.1
Age at baseline <18 421 2 0.5 6 1.4 126 30.4 24 5.8 158 38.5
18-19 183 2 1.1 1 0.6 46 26.0 11 6.0 64 36.4
20-24 526 9 1.7 6 1.1 100 19.5 38 7.3 172 33.5
CCSS data from Dec2010 and March 2015 data freeze 1 N and % based on response of 'Yes' 2 'Any hormonal problem' is based on a response of 'Yes' to one or more of the listed hormonal problems
Hormonal systems: All CNS 19
Overactive thyroid
(E.1/E.1) 1
Underactive thyroid
(E.2/E.2) 1
Thyroid nodules (E.3/E.3) 1
Thyroid enlargement
(E.4/E.4) 1
Diabetes- diet (E.5/E.5)
1
All cases N % N % N % N % N %
25-29 442 10 2.3 85 19.7 17 3.9 16 3.7 8 1.8
30-34 276 12 4.4 46 16.8 11 4.1 11 4.0 4 1.5
35+ 117 4 3.5 20 17.4 1 0.9 5 4.3 5 4.3
Years since diagnosis 5-9 199 5 2.5 34 17.3 1 0.5 . . 1 0.5
10-14 706 9 1.3 119 17.1 11 1.6 15 2.1 6 0.9
15-19 613 16 2.6 115 19.0 15 2.5 17 2.8 4 0.7
20+ 447 16 3.7 89 20.4 19 4.4 20 4.6 12 2.7
Age at diagnosis <1 89 1 1.1 12 13.6 . . . . 1 1.1
1-4 598 9 1.5 110 18.7 12 2.1 12 2.0 4 0.7
5-9 594 14 2.4 126 21.6 22 3.8 17 2.9 4 0.7
10-14 478 17 3.6 79 16.7 10 2.1 18 3.8 11 2.3
15-20 206 5 2.5 30 14.7 2 1.0 5 2.5 3 1.5
Treatment Surgery only 596 10 1.7 34 5.7 7 1.2 13 2.2 6 1.0
Chemotherapy, no radiation 148 1 0.7 17 11.6 2 1.4 3 2.0 3 2.0
Radiation, no chemotherapy 540 9 1.7 97 18.3 10 1.9 14 2.6 6 1.1
Chemotherapy and radiation 507 23 4.7 182 36.8 24 4.9 21 4.2 6 1.2
Unknown 174 3 1.8 27 15.7 3 1.7 1 0.6 2 1.2
CCSS data from Dec2010 and March 2015 data freeze 1 N and % based on response of 'Yes' 2 'Any hormonal problem' is based on a response of 'Yes' to one or more of the listed hormonal problems
Hormonal systems: All CNS 20
Diabetes- pills
(E.6/E.6) 1
Diabetes- insulin
(E.7/E.7) 1
Growth hormone deficiency (E.8/E.8) 1
Osteoporosis (E.10/E.10) 1
Any hormonal problem2
All cases N % N % N % N % N %
25-29 442 11 2.5 4 0.9 81 18.9 34 7.8 163 37.8
30-34 276 4 1.5 2 0.7 24 8.9 18 6.5 82 30.3
35+ 117 6 5.2 5 4.3 2 1.7 7 6.0 34 29.6
Years since diagnosis 5-9 199 1 0.5 3 1.5 47 23.9 9 4.5 64 32.8
10-14 706 6 0.9 5 0.7 142 20.7 49 7.0 234 34.0
15-19 613 10 1.6 9 1.5 115 19.1 36 5.9 202 33.7
20+ 447 17 3.9 7 1.6 75 17.2 38 8.6 173 40.0
Age at diagnosis <1 89 . . 1 1.1 24 27.6 7 8.0 32 36.8
1-4 598 10 1.7 6 1.0 148 25.3 42 7.1 219 37.9
5-9 594 8 1.4 8 1.4 156 27.0 40 6.8 228 39.4
10-14 478 11 2.3 4 0.8 41 8.7 32 6.8 146 31.0
15-20 206 5 2.5 5 2.4 10 4.9 11 5.4 48 23.6
Treatment Surgery only 596 4 0.7 3 0.5 10 1.7 14 2.4 70 12.0
Chemotherapy, no radiation 148 3 2.1 1 0.7 21 14.6 7 4.8 37 25.7
Radiation, no chemotherapy 540 10 1.9 6 1.1 120 23.0 37 7.0 199 38.1
Chemotherapy and radiation 507 16 3.2 11 2.2 205 41.7 60 12.0 313 63.4
Unknown 174 1 0.6 3 1.7 23 13.4 14 8.1 54 31.4
CCSS data from Dec2010 and March 2015 data freeze 1 N and % based on response of 'Yes' 2 'Any hormonal problem' is based on a response of 'Yes' to one or more of the listed hormonal problems
Hormonal systems: Astrocytomas 21
Overactive thyroid
(E.1/E.1) 1
Underactive thyroid
(E.2/E.2) 1
Thyroid nodules (E.3/E.3) 1
Thyroid enlargement
(E.4/E.4) 1
Diabetes- diet (E.5/E.5)
1
All cases N % N % N % N % N %
Both sexes All cases 2594 53 2.1 322 12.5 23 0.9 33 1.3 24 0.9
Age at baseline <18 527 6 1.1 82 15.7 1 0.2 2 0.4 4 0.8
18-19 211 4 1.9 25 12.0 3 1.4 1 0.5 . .
20-24 690 10 1.5 96 14.0 5 0.7 11 1.6 3 0.4
25-29 634 20 3.2 65 10.4 5 0.8 7 1.1 8 1.3
30-34 363 7 1.9 38 10.5 4 1.1 7 1.9 4 1.1
35+ 169 6 3.6 16 9.6 5 3.0 5 3.0 5 3.0
Years since diagnosis 5-9 237 6 2.5 38 16.1 . . . . 1 0.4
10-14 904 9 1.0 107 11.9 4 0.4 4 0.4 9 1.0
15-19 796 19 2.4 93 11.8 7 0.9 13 1.7 3 0.4
20+ 657 19 2.9 84 13.0 12 1.9 16 2.5 11 1.7
Age at diagnosis <1 142 2 1.4 31 22.3 . . . . 2 1.4
1-4 774 14 1.8 101 13.2 7 0.9 11 1.4 5 0.6
5-9 767 15 2.0 98 12.9 9 1.2 10 1.3 3 0.4
10-14 619 17 2.8 69 11.2 2 0.3 6 1.0 9 1.5
15-20 292 5 1.7 23 8.0 5 1.7 6 2.1 5 1.7
Treatment Surgery only 1004 17 1.7 41 4.1 7 0.7 10 1.0 9 0.9
Chemotherapy, no radiation 229 7 3.1 35 15.4 1 0.4 3 1.3 5 2.2
Radiation, no chemotherapy 704 14 2.0 102 14.7 6 0.9 8 1.2 5 0.7
Chemotherapy and radiation 403 9 2.3 115 29.0 7 1.8 10 2.5 4 1.0
Unknown 254 6 2.4 29 11.5 2 0.8 2 0.8 1 0.4
Males All cases 1354 29 2.2 169 12.6 8 0.6 13 1.0 7 0.5
Age at baseline <18 279 5 1.8 50 17.9 . . 2 0.7 3 1.1
18-19 106 2 1.9 12 11.4 1 0.9 . . . .
20-24 342 4 1.2 50 14.7 1 0.3 4 1.2 . .
25-29 357 12 3.4 35 9.9 1 0.3 3 0.8 1 0.3
30-34 181 3 1.7 18 10.0 1 0.6 2 1.1 2 1.1
35+ 89 3 3.4 4 4.5 4 4.6 2 2.3 1 1.1
Years since diagnosis 5-9 125 2 1.6 24 19.2 . . . . . .
10-14 477 7 1.5 62 13.0 1 0.2 2 0.4 5 1.1
15-19 404 9 2.3 47 11.8 4 1.0 7 1.8 1 0.3
20+ 348 11 3.2 36 10.5 3 0.9 4 1.2 1 0.3
Age at diagnosis <1 79 1 1.3 21 27.3 . . . . 1 1.3
1-4 391 8 2.1 51 13.1 1 0.3 5 1.3 1 0.3
5-9 407 9 2.2 54 13.4 2 0.5 4 1.0 1 0.2
10-14 320 10 3.1 35 10.9 1 0.3 2 0.6 1 0.3
15-20 157 1 0.6 8 5.2 4 2.6 2 1.3 3 1.9
Treatment Surgery only 504 7 1.4 16 3.2 1 0.2 1 0.2 3 0.6
Chemotherapy, no radiation 127 6 4.8 24 19.0 . . 2 1.6 2 1.6
Radiation, no chemotherapy 356 7 2.0 51 14.4 6 1.7 6 1.7 1 0.3
Chemotherapy and radiation 229 4 1.8 66 29.3 1 0.4 3 1.3 1 0.4
Unknown 138 5 3.6 12 8.7 . . 1 0.7 . .
Females All cases 1240 24 2.0 153 12.5 15 1.2 20 1.6 17 1.4
Age at baseline <18 248 1 0.4 32 13.1 1 0.4 . . 1 0.4
18-19 105 2 1.9 13 12.5 2 1.9 1 1.0 . .
20-24 348 6 1.7 46 13.3 4 1.2 7 2.0 3 0.9
CCSS data from Dec2010 and March 2015 data freeze 1 N and % based on response of 'Yes' 2 'Any hormonal problem' is based on a response of 'Yes' to one or more of the listed hormonal problems
Hormonal systems: Astrocytomas 22
Diabetes- pills
(E.6/E.6) 1
Diabetes- insulin
(E.7/E.7) 1
Growth hormone deficiency (E.8/E.8) 1
Osteoporosis (E.10/E.10) 1
Any hormonal problem2
All cases N % N % N % N % N %
Both sexes All cases 2594 29 1.1 24 0.9 371 14.6 125 4.9 657 26.1
Age at baseline <18 527 3 0.6 5 1.0 130 24.9 21 4.0 171 32.9
18-19 211 2 1.0 2 1.0 37 18.3 14 6.6 57 28.4
20-24 690 5 0.7 5 0.7 106 15.6 34 5.0 177 26.3
25-29 634 11 1.8 6 1.0 71 11.5 37 5.9 152 24.7
30-34 363 3 0.8 3 0.8 21 6.0 11 3.0 66 18.9
35+ 169 5 3.0 3 1.8 6 3.6 8 4.8 34 20.9
Years since diagnosis 5-9 237 1 0.4 3 1.3 50 21.6 9 3.8 72 31.2
10-14 904 6 0.7 6 0.7 131 14.8 49 5.5 223 25.3
15-19 796 5 0.6 6 0.8 108 13.8 32 4.1 189 24.3
20+ 657 17 2.6 9 1.4 82 12.8 35 5.4 173 27.4
Age at diagnosis <1 142 1 0.7 1 0.7 40 28.8 9 6.5 56 40.6
1-4 774 8 1.0 4 0.5 157 20.7 37 4.8 228 30.2
5-9 767 9 1.2 10 1.3 119 15.8 37 4.9 193 25.9
10-14 619 6 1.0 5 0.8 46 7.5 30 4.9 133 21.9
15-20 292 5 1.8 4 1.4 9 3.2 12 4.2 47 17.0
Treatment Surgery only 1004 3 0.3 3 0.3 22 2.2 24 2.4 100 10.2
Chemotherapy, no radiation 229 4 1.8 1 0.4 32 14.2 8 3.5 63 28.1
Radiation, no chemotherapy 704 10 1.5 7 1.0 153 22.4 44 6.3 233 34.4
Chemotherapy and radiation 403 10 2.5 9 2.3 132 33.4 39 9.8 195 50.0
Unknown 254 2 0.8 4 1.6 32 12.7 10 4.0 66 26.3
Males All cases 1354 8 0.6 7 0.5 211 16.0 51 3.8 335 25.5
Age at baseline <18 279 1 0.4 1 0.4 74 26.6 6 2.2 97 35.0
18-19 106 . . 1 1.0 23 23.2 10 9.4 33 33.3
20-24 342 . . 1 0.3 60 17.9 13 3.8 88 26.3
25-29 357 4 1.1 2 0.6 38 10.9 14 3.9 74 21.3
30-34 181 2 1.1 1 0.6 12 6.9 5 2.8 31 18.2
35+ 89 1 1.1 1 1.1 4 4.6 3 3.4 12 14.1
Years since diagnosis 5-9 125 . . 1 0.8 29 24.0 5 4.0 43 35.5
10-14 477 2 0.4 2 0.4 78 16.7 22 4.6 123 26.4
15-19 404 1 0.3 1 0.3 61 15.5 14 3.5 98 24.9
20+ 348 5 1.5 3 0.9 43 12.7 10 2.9 71 21.3
Age at diagnosis <1 79 1 1.3 . . 21 26.9 4 5.2 31 40.3
1-4 391 1 0.3 . . 94 24.5 8 2.1 117 30.5
5-9 407 3 0.8 4 1.0 62 15.6 20 4.9 100 25.4
10-14 320 1 0.3 1 0.3 31 9.8 13 4.1 66 21.0
15-20 157 2 1.4 2 1.3 3 2.1 6 3.9 21 14.5
Treatment Surgery only 504 1 0.2 2 0.4 14 2.9 11 2.2 45 9.2
Chemotherapy, no radiation 127 1 0.8 . . 18 14.2 2 1.6 37 29.4
Radiation, no chemotherapy 356 3 0.9 2 0.6 82 23.8 15 4.2 117 34.2
Chemotherapy and radiation 229 1 0.4 2 0.9 74 33.2 19 8.4 102 46.4
Unknown 138 2 1.5 1 0.7 23 16.9 4 2.9 34 25.0
Females All cases 1240 21 1.7 17 1.4 160 13.1 74 6.0 322 26.6
Age at baseline <18 248 2 0.8 4 1.6 56 22.9 15 6.1 74 30.5
18-19 105 2 1.9 1 1.0 14 13.6 4 3.8 24 23.5
20-24 348 5 1.5 4 1.2 46 13.4 21 6.1 89 26.3
CCSS data from Dec2010 and March 2015 data freeze 1 N and % based on response of 'Yes' 2 'Any hormonal problem' is based on a response of 'Yes' to one or more of the listed hormonal problems
Hormonal systems: Astrocytomas 23
Overactive thyroid
(E.1/E.1) 1
Underactive thyroid
(E.2/E.2) 1
Thyroid nodules (E.3/E.3) 1
Thyroid enlargement
(E.4/E.4) 1
Diabetes- diet (E.5/E.5)
1
All cases N % N % N % N % N %
25-29 277 8 3.0 30 11.1 4 1.5 4 1.5 7 2.6
30-34 182 4 2.2 20 11.0 3 1.7 5 2.8 2 1.1
35+ 80 3 3.8 12 15.4 1 1.3 3 3.8 4 5.1
Years since diagnosis 5-9 112 4 3.6 14 12.6 . . . . 1 0.9
10-14 427 2 0.5 45 10.7 3 0.7 2 0.5 4 0.9
15-19 392 10 2.6 46 11.8 3 0.8 6 1.6 2 0.5
20+ 309 8 2.6 48 15.8 9 3.0 12 3.9 10 3.3
Age at diagnosis <1 63 1 1.6 10 16.1 . . . . 1 1.6
1-4 383 6 1.6 50 13.2 6 1.6 6 1.6 4 1.0
5-9 360 6 1.7 44 12.4 7 2.0 6 1.7 2 0.6
10-14 299 7 2.4 34 11.5 1 0.3 4 1.4 8 2.7
15-20 135 4 3.0 15 11.3 1 0.7 4 3.0 2 1.5
Treatment Surgery only 500 10 2.0 25 5.0 6 1.2 9 1.8 6 1.2
Chemotherapy, no radiation 102 1 1.0 11 10.9 1 1.0 1 1.0 3 3.0
Radiation, no chemotherapy 348 7 2.0 51 14.9 . . 2 0.6 4 1.2
Chemotherapy and radiation 174 5 2.9 49 28.7 6 3.5 7 4.1 3 1.7
Unknown 116 1 0.9 17 14.9 2 1.7 1 0.9 1 0.9
CCSS data from Dec2010 and March 2015 data freeze 1 N and % based on response of 'Yes' 2 'Any hormonal problem' is based on a response of 'Yes' to one or more of the listed hormonal problems
Hormonal systems: Astrocytomas 24
Diabetes- pills
(E.6/E.6) 1
Diabetes- insulin
(E.7/E.7) 1
Growth hormone deficiency (E.8/E.8) 1
Osteoporosis (E.10/E.10) 1
Any hormonal problem2
All cases N % N % N % N % N %
25-29 277 7 2.6 4 1.5 33 12.3 23 8.5 78 29.1
30-34 182 1 0.6 2 1.1 9 5.0 6 3.3 35 19.6
35+ 80 4 5.1 2 2.5 2 2.5 5 6.3 22 28.2
Years since diagnosis 5-9 112 1 0.9 2 1.8 21 18.9 4 3.6 29 26.4
10-14 427 4 1.0 4 0.9 53 12.6 27 6.4 100 24.0
15-19 392 4 1.0 5 1.3 47 12.1 18 4.7 91 23.6
20+ 309 12 3.9 6 2.0 39 13.0 25 8.1 102 34.2
Age at diagnosis <1 63 . . 1 1.6 19 31.1 5 8.1 25 41.0
1-4 383 7 1.9 4 1.1 63 16.8 29 7.7 111 29.8
5-9 360 6 1.7 6 1.7 57 16.1 17 4.8 93 26.5
10-14 299 5 1.7 4 1.4 15 5.1 17 5.8 67 22.9
15-20 135 3 2.3 2 1.5 6 4.5 6 4.5 26 19.7
Treatment Surgery only 500 2 0.4 1 0.2 8 1.6 13 2.6 55 11.2
Chemotherapy, no radiation 102 3 3.0 1 1.0 14 14.3 6 6.0 26 26.5
Radiation, no chemotherapy 348 7 2.0 5 1.5 71 21.0 29 8.5 116 34.6
Chemotherapy and radiation 174 9 5.2 7 4.0 58 33.7 20 11.6 93 54.7
Unknown 116 . . 3 2.6 9 7.8 6 5.2 32 27.8
CCSS data from Dec2010 and March 2015 data freeze 1 N and % based on response of 'Yes' 2 'Any hormonal problem' is based on a response of 'Yes' to one or more of the listed hormonal problems
Hormonal systems: Medulloblastoma/PNET 25
Overactive thyroid
(E.1/E.1) 1
Underactive thyroid
(E.2/E.2) 1
Thyroid nodules (E.3/E.3) 1
Thyroid enlargement
(E.4/E.4) 1
Diabetes- diet (E.5/E.5)
1
All cases N % N % N % N % N %
Both sexes All cases 997 42 4.3 388 39.7 37 3.8 28 2.8 8 0.8
Age at baseline <18 245 6 2.5 88 36.2 7 2.9 2 0.8 1 0.4
18-19 83 3 3.7 33 40.2 1 1.2 2 2.4 1 1.2
20-24 280 15 5.5 112 40.9 9 3.3 5 1.8 1 0.4
25-29 242 9 3.8 99 42.1 12 5.1 13 5.5 1 0.4
30-34 120 8 6.9 49 41.5 8 6.8 4 3.4 3 2.5
35+ 27 1 3.8 7 26.9 . . 2 8.0 1 3.8
Years since diagnosis 5-9 123 1 0.8 40 33.1 1 0.8 1 0.8 . .
10-14 354 18 5.2 139 39.6 11 3.2 7 2.0 2 0.6
15-19 329 11 3.4 133 41.6 15 4.7 13 4.0 2 0.6
20+ 191 12 6.6 76 40.9 10 5.4 7 3.7 4 2.1
Age at diagnosis <1 27 . . 4 14.8 . . . . . .
1-4 289 13 4.6 117 41.1 12 4.2 5 1.7 1 0.3
5-9 402 14 3.6 174 44.5 17 4.4 13 3.3 5 1.3
10-14 221 14 6.5 80 36.9 7 3.2 9 4.1 2 0.9
15-20 58 1 1.7 13 22.4 1 1.8 1 1.8 . .
Treatment Surgery only 9 . . 3 33.3 . . . . . .
Chemotherapy, no radiation 46 1 2.2 4 8.7 . . . . . .
Radiation, no chemotherapy 201 3 1.6 60 30.9 13 6.7 10 5.1 . .
Chemotherapy and radiation 672 35 5.3 307 46.4 23 3.5 17 2.6 7 1.0
Unknown 69 3 4.4 14 20.9 1 1.5 1 1.5 1 1.4
Males All cases 608 26 4.4 239 40.0 14 2.3 10 1.7 4 0.7
Age at baseline <18 147 5 3.5 55 37.7 4 2.7 1 0.7 1 0.7
18-19 47 1 2.1 19 40.4 1 2.1 1 2.1 1 2.2
20-24 178 11 6.3 76 43.4 4 2.3 2 1.1 . .
25-29 152 7 4.7 56 38.1 3 2.0 5 3.4 1 0.7
30-34 68 2 3.0 29 42.6 2 3.0 . . 1 1.5
35+ 16 . . 4 26.7 . . 1 6.7 . .
Years since diagnosis 5-9 76 . . 23 30.7 . . 1 1.3 . .
10-14 207 12 5.9 90 43.7 5 2.4 1 0.5 2 1.0
15-19 209 8 3.9 76 37.4 5 2.5 5 2.4 . .
20+ 116 6 5.4 50 43.9 4 3.5 3 2.6 2 1.7
Age at diagnosis <1 15 . . 3 20.0 . . . . . .
1-4 176 12 6.9 70 40.0 8 4.6 4 2.3 1 0.6
5-9 255 8 3.2 112 45.0 5 2.0 4 1.6 3 1.2
10-14 127 6 4.9 48 38.7 1 0.8 1 0.8 . .
15-20 35 . . 6 17.1 . . 1 2.9 . .
Treatment Surgery only 6 . . 3 50.0 . . . . . .
Chemotherapy, no radiation 22 1 4.5 1 4.5 . . . . . .
Radiation, no chemotherapy 110 2 1.9 30 28.0 4 3.8 2 1.9 . .
Chemotherapy and radiation 431 21 5.0 197 46.2 10 2.4 7 1.6 4 0.9
Unknown 39 2 5.3 8 21.6 . . 1 2.6 . .
Females All cases 389 16 4.3 149 39.2 23 6.1 18 4.7 4 1.0
Age at baseline <18 98 1 1.0 33 34.0 3 3.2 1 1.0 . .
18-19 36 2 5.7 14 40.0 . . 1 2.9 . .
20-24 102 4 4.1 36 36.4 5 5.0 3 3.0 1 1.0
CCSS data from Dec2010 and March 2015 data freeze 1 N and % based on response of 'Yes' 2 'Any hormonal problem' is based on a response of 'Yes' to one or more of the listed hormonal problems
Hormonal systems: Medulloblastoma/PNET 26
Diabetes- pills
(E.6/E.6) 1
Diabetes- insulin
(E.7/E.7) 1
Growth hormone deficiency (E.8/E.8) 1
Osteoporosis (E.10/E.10) 1
Any hormonal problem2
All cases N % N % N % N % N %
Both sexes All cases 997 11 1.1 3 0.3 469 47.9 96 9.7 637 65.1
Age at baseline <18 245 1 0.4 1 0.4 140 57.9 20 8.2 165 69.0
18-19 83 . . . . 53 66.3 5 6.2 59 73.8
20-24 280 3 1.1 1 0.4 137 49.8 30 10.9 179 64.9
25-29 242 5 2.1 . . 102 43.0 22 9.3 151 63.2
30-34 120 1 0.8 . . 35 29.7 18 15.1 73 61.9
35+ 27 1 3.8 1 3.7 2 7.4 1 3.7 10 37.0
Years since diagnosis 5-9 123 . . 1 0.8 58 47.5 11 8.9 74 61.2
10-14 354 1 0.3 . . 172 49.7 31 8.9 230 66.1
15-19 329 5 1.5 2 0.6 155 48.0 27 8.4 208 64.6
20+ 191 5 2.6 . . 84 44.7 27 14.3 125 66.5
Age at diagnosis <1 27 . . . . 8 29.6 2 7.4 10 38.5
1-4 289 4 1.4 . . 176 62.0 25 8.7 208 73.8
5-9 402 5 1.3 2 0.5 214 54.6 42 10.6 278 70.9
10-14 221 2 0.9 . . 65 29.8 23 10.6 123 55.7
15-20 58 . . 1 1.7 6 10.3 4 6.9 18 31.0
Treatment Surgery only 9 1 11.1 . . 2 22.2 . . 4 44.4
Chemotherapy, no radiation 46 . . . . 8 17.4 . . 10 22.2
Radiation, no chemotherapy 201 . . 1 0.5 67 34.4 12 6.0 108 55.4
Chemotherapy and radiation 672 10 1.5 2 0.3 366 55.5 79 11.9 481 72.8
Unknown 69 . . . . 26 37.7 5 7.2 34 49.3
Males All cases 608 5 0.8 1 0.2 306 50.8 59 9.8 389 64.9
Age at baseline <18 147 1 0.7 . . 85 58.2 12 8.2 102 70.8
18-19 47 . . . . 31 67.4 3 6.5 33 71.7
20-24 178 . . 1 0.6 98 55.4 21 11.9 121 68.8
25-29 152 4 2.6 . . 68 45.3 15 10.1 91 60.7
30-34 68 . . . . 22 32.8 8 11.8 37 55.2
35+ 16 . . . . 2 12.5 . . 5 31.3
Years since diagnosis 5-9 76 . . . . 38 50.0 7 9.2 45 60.0
10-14 207 1 0.5 . . 105 51.5 19 9.3 139 68.1
15-19 209 2 1.0 1 0.5 105 50.7 17 8.3 128 62.4
20+ 116 2 1.7 . . 58 50.4 16 13.8 77 67.0
Age at diagnosis <1 15 . . . . 5 33.3 1 6.7 6 42.9
1-4 176 2 1.1 . . 112 64.0 16 9.1 131 75.3
5-9 255 3 1.2 1 0.4 141 56.2 28 11.2 176 70.7
10-14 127 . . . . 46 36.5 13 10.5 70 55.1
15-20 35 . . . . 2 5.7 1 2.9 6 17.1
Treatment Surgery only 6 . . . . 2 33.3 . . 3 50.0
Chemotherapy, no radiation 22 . . . . 2 9.1 . . 4 19.0
Radiation, no chemotherapy 110 . . . . 37 33.9 8 7.3 56 52.3
Chemotherapy and radiation 431 5 1.2 1 0.2 249 58.5 51 12.0 307 72.1
Unknown 39 . . . . 16 41.0 . . 19 48.7
Females All cases 389 6 1.6 2 0.5 163 43.2 37 9.6 248 65.3
Age at baseline <18 98 . . 1 1.0 55 57.3 8 8.2 63 66.3
18-19 36 . . . . 22 64.7 2 5.7 26 76.5
20-24 102 3 3.0 . . 39 39.8 9 9.0 58 58.0
CCSS data from Dec2010 and March 2015 data freeze 1 N and % based on response of 'Yes' 2 'Any hormonal problem' is based on a response of 'Yes' to one or more of the listed hormonal problems
Hormonal systems: Medulloblastoma/PNET 27
Overactive thyroid
(E.1/E.1) 1
Underactive thyroid
(E.2/E.2) 1
Thyroid nodules (E.3/E.3) 1
Thyroid enlargement
(E.4/E.4) 1
Diabetes- diet (E.5/E.5)
1
All cases N % N % N % N % N %
25-29 90 2 2.3 43 48.9 9 10.1 8 9.0 . .
30-34 52 6 12.0 20 40.0 6 12.0 4 7.8 2 3.9
35+ 11 1 9.1 3 27.3 . . 1 10.0 1 10.0
Years since diagnosis 5-9 47 1 2.2 17 37.0 1 2.1 . . . .
10-14 147 6 4.2 49 33.8 6 4.2 6 4.1 . .
15-19 120 3 2.6 57 48.7 10 8.5 8 6.8 2 1.7
20+ 75 6 8.7 26 36.1 6 8.3 4 5.5 2 2.7
Age at diagnosis <1 12 . . 1 8.3 . . . . . .
1-4 113 1 0.9 47 42.7 4 3.7 1 0.9 . .
5-9 147 6 4.3 62 43.7 12 8.5 9 6.3 2 1.4
10-14 94 8 8.5 32 34.4 6 6.4 8 8.5 2 2.1
15-20 23 1 4.3 7 30.4 1 4.5 . . . .
Treatment Surgery only 3 . . . . . . . . . .
Chemotherapy, no radiation 24 . . 3 12.5 . . . . . .
Radiation, no chemotherapy 91 1 1.1 30 34.5 9 10.3 8 9.1 . .
Chemotherapy and radiation 241 14 6.0 110 46.6 13 5.6 10 4.2 3 1.3
Unknown 30 1 3.3 6 20.0 1 3.3 . . 1 3.3
CCSS data from Dec2010 and March 2015 data freeze 1 N and % based on response of 'Yes' 2 'Any hormonal problem' is based on a response of 'Yes' to one or more of the listed hormonal problems
Hormonal systems: Medulloblastoma/PNET 28
Diabetes- pills
(E.6/E.6) 1
Diabetes- insulin
(E.7/E.7) 1
Growth hormone deficiency (E.8/E.8) 1
Osteoporosis (E.10/E.10) 1
Any hormonal problem2
All cases N % N % N % N % N %
25-29 90 1 1.1 . . 34 39.1 7 7.9 60 67.4
30-34 52 1 2.0 . . 13 25.5 10 19.6 36 70.6
35+ 11 1 10.0 1 9.1 . . 1 9.1 5 45.5
Years since diagnosis 5-9 47 . . 1 2.1 20 43.5 4 8.5 29 63.0
10-14 147 . . . . 67 47.2 12 8.3 91 63.2
15-19 120 3 2.5 1 0.8 50 43.1 10 8.4 80 68.4
20+ 75 3 4.1 . . 26 35.6 11 15.1 48 65.8
Age at diagnosis <1 12 . . . . 3 25.0 1 8.3 4 33.3
1-4 113 2 1.8 . . 64 58.7 9 8.0 77 71.3
5-9 147 2 1.4 1 0.7 73 51.8 14 9.7 102 71.3
10-14 94 2 2.2 . . 19 20.7 10 10.8 53 56.4
15-20 23 . . 1 4.3 4 17.4 3 13.0 12 52.2
Treatment Surgery only 3 1 33.3 . . . . . . 1 33.3
Chemotherapy, no radiation 24 . . . . 6 25.0 . . 6 25.0
Radiation, no chemotherapy 91 . . 1 1.1 30 34.9 4 4.5 52 59.1
Chemotherapy and radiation 241 5 2.1 1 0.4 117 50.0 28 11.8 174 74.0
Unknown 30 . . . . 10 33.3 5 16.7 15 50.0
CCSS data from Dec2010 and March 2015 data freeze 1 N and % based on response of 'Yes' 2 'Any hormonal problem' is based on a response of 'Yes' to one or more of the listed hormonal problems
Hormonal systems: Hodgkin 29
Overactive thyroid
(E.1/E.1) 1
Underactive thyroid
(E.2/E.2) 1
Thyroid nodules (E.3/E.3) 1
Thyroid enlargement
(E.4/E.4) 1
Diabetes- diet (E.5/E.5)
1
All cases N % N % N % N % N %
Both sexes All cases 2996 143 4.8 870 29.3 259 8.7 208 7.0 40 1.3
Age at baseline <18 61 1 1.7 17 28.8 1 1.7 4 6.8 . .
18-19 62 2 3.3 8 13.1 5 8.1 5 8.1 1 1.6
20-24 372 17 4.6 59 15.9 20 5.4 20 5.4 1 0.3
25-29 783 24 3.1 205 26.4 46 5.9 49 6.3 12 1.5
30-34 912 57 6.3 286 31.7 84 9.4 62 6.9 17 1.9
35+ 806 42 5.3 295 36.7 103 12.9 68 8.5 9 1.1
Years since diagnosis 5-9 242 7 2.9 48 19.9 4 1.7 12 5.0 1 0.4
10-14 947 40 4.3 252 26.9 44 4.7 43 4.6 13 1.4
15-19 967 52 5.4 306 31.9 92 9.6 73 7.7 13 1.4
20+ 840 44 5.3 264 31.7 119 14.3 80 9.7 13 1.6
Age at diagnosis 1-4 79 3 3.8 18 22.8 8 10.3 9 11.5 1 1.3
5-9 404 22 5.5 73 18.2 43 10.8 37 9.3 5 1.2
10-14 1075 47 4.4 271 25.5 101 9.5 82 7.7 15 1.4
15-20 1438 71 5.0 508 35.5 107 7.5 80 5.6 19 1.3
Treatment Surgery only 2 . . 1 50.0 1 50.0 1 50.0 . .
Chemotherapy, no radiation 327 6 1.8 26 8.0 8 2.5 12 3.7 5 1.5
Radiation, no chemotherapy 626 36 5.8 237 38.2 78 12.6 52 8.5 3 0.5
Chemotherapy and radiation 1750 87 5.0 545 31.4 155 9.0 132 7.6 27 1.6
Unknown 291 14 4.9 61 21.1 17 5.9 11 3.8 5 1.7
Males All cases 1576 69 4.4 340 21.7 67 4.3 78 5.0 17 1.1
Age at baseline <18 46 1 2.2 14 31.1 1 2.2 2 4.4 . .
18-19 49 1 2.1 7 14.3 4 8.2 5 10.2 . .
20-24 238 11 4.6 30 12.6 10 4.2 10 4.2 1 0.4
25-29 437 10 2.3 97 22.3 21 4.8 24 5.5 5 1.1
30-34 458 25 5.5 100 22.0 20 4.4 22 4.9 7 1.5
35+ 348 21 6.1 92 26.5 11 3.2 15 4.4 4 1.2
Years since diagnosis 5-9 138 2 1.5 21 15.3 3 2.2 4 2.9 1 0.7
10-14 493 17 3.5 107 21.7 13 2.6 20 4.1 5 1.0
15-19 515 27 5.3 119 23.2 23 4.5 25 4.9 6 1.2
20+ 430 23 5.4 93 21.8 28 6.6 29 6.9 5 1.2
Age at diagnosis 1-4 61 3 5.0 15 24.6 5 8.3 6 10.0 1 1.6
5-9 297 17 5.7 45 15.2 23 7.8 24 8.2 2 0.7
10-14 558 17 3.1 103 18.6 27 4.9 24 4.4 5 0.9
15-20 660 32 4.9 177 26.9 12 1.8 24 3.7 9 1.4
Treatment Surgery only 2 . . 1 50.0 1 50.0 1 50.0 . .
Chemotherapy, no radiation 168 1 0.6 9 5.4 . . 4 2.4 3 1.8
Radiation, no chemotherapy 323 18 5.6 93 29.1 19 6.0 16 5.1 1 0.3
Chemotherapy and radiation 906 42 4.7 211 23.4 42 4.7 52 5.8 11 1.2
Unknown 177 8 4.6 26 14.8 5 2.8 5 2.8 2 1.1
Females All cases 1420 74 5.3 530 37.8 192 13.7 130 9.3 23 1.6
Age at baseline <18 15 . . 3 21.4 . . 2 14.3 . .
18-19 13 1 8.3 1 8.3 1 7.7 . . 1 7.7
20-24 134 6 4.5 29 21.8 10 7.5 10 7.5 . .
25-29 346 14 4.1 108 31.6 25 7.3 25 7.4 7 2.0
30-34 454 32 7.2 186 41.7 64 14.4 40 9.0 10 2.2
CCSS data from Dec2010 and March 2015 data freeze 1 N and % based on response of 'Yes' 2 'Any hormonal problem' is based on a response of 'Yes' to one or more of the listed hormonal problems
Hormonal systems: Hodgkin 30
Diabetes- pills
(E.6/E.6) 1
Diabetes- insulin
(E.7/E.7) 1
Growth hormone deficiency (E.8/E.8) 1
Osteoporosis (E.10/E.10) 1
Any hormonal problem2
All cases N % N % N % N % N %
Both sexes All cases 2996 37 1.3 31 1.0 33 1.1 97 3.3 1238 42.4
Age at baseline <18 61 . . 1 1.7 6 10.0 1 1.7 24 40.7
18-19 62 1 1.7 . . 2 3.3 2 3.2 17 28.3
20-24 372 1 0.3 . . 10 2.8 11 3.0 107 29.7
25-29 783 6 0.8 7 0.9 6 0.8 18 2.3 270 35.5
30-34 912 14 1.6 13 1.4 6 0.7 33 3.6 409 46.1
35+ 806 15 1.9 10 1.2 3 0.4 32 4.0 411 51.8
Years since diagnosis 5-9 242 2 0.9 . . 4 1.8 5 2.1 70 30.0
10-14 947 6 0.7 7 0.7 13 1.4 25 2.7 340 37.2
15-19 967 9 1.0 12 1.2 8 0.9 32 3.3 432 45.8
20+ 840 20 2.4 12 1.4 8 1.0 35 4.2 396 47.6
Age at diagnosis 1-4 79 2 2.6 1 1.3 6 7.7 2 2.5 31 39.2
5-9 404 2 0.5 2 0.5 14 3.5 14 3.5 137 34.7
10-14 1075 13 1.3 15 1.4 9 0.9 41 3.8 414 39.5
15-20 1438 20 1.4 13 0.9 4 0.3 40 2.8 656 46.9
Treatment Surgery only 2 . . . . . . 1 50.0 1 50.0
Chemotherapy, no radiation 327 9 2.8 1 0.3 3 0.9 9 2.8 60 19.1
Radiation, no chemotherapy 626 6 1.0 7 1.1 2 0.3 7 1.1 319 52.9
Chemotherapy and radiation 1750 18 1.1 21 1.2 21 1.2 66 3.8 766 44.7
Unknown 291 4 1.4 2 0.7 7 2.4 14 4.8 92 31.9
Males All cases 1576 26 1.7 11 0.7 19 1.2 33 2.1 507 33.0
Age at baseline <18 46 . . . . 4 8.7 1 2.2 19 42.2
18-19 49 1 2.1 . . 2 4.3 2 4.1 14 29.8
20-24 238 1 0.4 . . 7 3.0 7 2.9 57 24.8
25-29 437 4 0.9 3 0.7 2 0.5 9 2.1 129 30.5
30-34 458 9 2.0 5 1.1 3 0.7 6 1.3 154 34.4
35+ 348 11 3.2 3 0.9 1 0.3 8 2.3 134 39.1
Years since diagnosis 5-9 138 1 0.8 . . 3 2.3 2 1.4 33 25.4
10-14 493 5 1.1 3 0.6 7 1.5 12 2.4 147 30.8
15-19 515 6 1.2 5 1.0 5 1.0 9 1.8 179 35.7
20+ 430 14 3.3 3 0.7 4 0.9 10 2.3 148 34.6
Age at diagnosis 1-4 61 2 3.3 . . 4 6.6 2 3.3 23 37.7
5-9 297 1 0.3 . . 10 3.4 9 3.0 88 30.3
10-14 558 10 1.8 6 1.1 4 0.7 14 2.5 164 30.1
15-20 660 13 2.0 5 0.8 1 0.2 8 1.2 232 36.2
Treatment Surgery only 2 . . . . . . 1 50.0 1 50.0
Chemotherapy, no radiation 168 6 3.7 1 0.6 2 1.2 . . 19 11.7
Radiation, no chemotherapy 323 6 2.0 2 0.6 1 0.3 2 0.6 130 42.1
Chemotherapy and radiation 906 11 1.2 7 0.8 10 1.1 21 2.3 311 35.1
Unknown 177 3 1.7 1 0.6 6 3.4 9 5.1 46 26.1
Females All cases 1420 11 0.8 20 1.4 14 1.0 64 4.5 731 52.8
Age at baseline <18 15 . . 1 7.1 2 14.3 . . 5 35.7
18-19 13 . . . . . . . . 3 23.1
20-24 134 . . . . 3 2.4 4 3.0 50 38.5
25-29 346 2 0.6 4 1.2 4 1.2 9 2.6 141 41.8
30-34 454 5 1.1 8 1.8 3 0.7 27 6.0 255 58.0
CCSS data from Dec2010 and March 2015 data freeze 1 N and % based on response of 'Yes' 2 'Any hormonal problem' is based on a response of 'Yes' to one or more of the listed hormonal problems
Hormonal systems: Hodgkin 31
Overactive thyroid
(E.1/E.1) 1
Underactive thyroid
(E.2/E.2) 1
Thyroid nodules (E.3/E.3) 1
Thyroid enlargement
(E.4/E.4) 1
Diabetes- diet (E.5/E.5)
1
All cases N % N % N % N % N %
35+ 458 21 4.6 203 44.5 92 20.2 53 11.7 5 1.1
Years since diagnosis 5-9 104 5 4.8 27 26.0 1 1.0 8 7.7 . .
10-14 454 23 5.2 145 32.6 31 6.9 23 5.2 8 1.8
15-19 452 25 5.6 187 41.8 69 15.5 48 10.9 7 1.6
20+ 410 21 5.2 171 42.0 91 22.4 51 12.5 8 2.0
Age at diagnosis 1-4 18 . . 3 16.7 3 16.7 3 16.7 . .
5-9 107 5 4.8 28 26.7 20 19.0 13 12.3 3 2.8
10-14 517 30 5.9 168 33.1 74 14.5 58 11.4 10 2.0
15-20 778 39 5.1 331 42.9 95 12.4 56 7.3 10 1.3
Treatment Chemotherapy, no radiation 159 5 3.2 17 10.8 8 5.1 8 5.1 2 1.3
Radiation, no chemotherapy 303 18 6.0 144 48.0 59 19.7 36 12.2 2 0.7
Chemotherapy and radiation 844 45 5.4 334 40.1 113 13.6 80 9.6 16 1.9
Unknown 114 6 5.4 35 31.0 12 10.6 6 5.3 3 2.7
CCSS data from Dec2010 and March 2015 data freeze 1 N and % based on response of 'Yes' 2 'Any hormonal problem' is based on a response of 'Yes' to one or more of the listed hormonal problems
Hormonal systems: Hodgkin 32
Diabetes- pills
(E.6/E.6) 1
Diabetes- insulin
(E.7/E.7) 1
Growth hormone deficiency (E.8/E.8) 1
Osteoporosis (E.10/E.10) 1
Any hormonal problem2
All cases N % N % N % N % N %
35+ 458 4 0.9 7 1.5 2 0.4 24 5.3 277 61.4
Years since diagnosis 5-9 104 1 1.0 . . 1 1.0 3 2.9 37 35.9
10-14 454 1 0.2 4 0.9 6 1.4 13 2.9 193 44.3
15-19 452 3 0.7 7 1.6 3 0.7 23 5.1 253 57.2
20+ 410 6 1.5 9 2.2 4 1.0 25 6.1 248 61.4
Age at diagnosis 1-4 18 . . 1 5.6 2 11.8 . . 8 44.4
5-9 107 1 1.0 2 1.9 4 3.8 5 4.7 49 46.7
10-14 517 3 0.6 9 1.8 5 1.0 27 5.3 250 49.7
15-20 778 7 0.9 8 1.0 3 0.4 32 4.1 424 55.9
Treatment Chemotherapy, no radiation 159 3 1.9 . . 1 0.6 9 5.7 41 27.0
Radiation, no chemotherapy 303 . . 5 1.7 1 0.4 5 1.7 189 64.3
Chemotherapy and radiation 844 7 0.8 14 1.7 11 1.3 45 5.4 455 55.0
Unknown 114 1 0.9 1 0.9 1 0.9 5 4.4 46 41.1
CCSS data from Dec2010 and March 2015 data freeze 1 N and % based on response of 'Yes' 2 'Any hormonal problem' is based on a response of 'Yes' to one or more of the listed hormonal problems
Hormonal systems: NHL 33
Overactive thyroid
(E.1/E.1) 1
Underactive thyroid
(E.2/E.2) 1
Thyroid nodules (E.3/E.3) 1
Thyroid enlargement
(E.4/E.4) 1
Diabetes- diet (E.5/E.5)
1
All cases N % N % N % N % N %
Both sexes All cases 1987 23 1.2 118 6.0 40 2.0 43 2.2 33 1.7
Age at baseline <18 212 1 0.5 8 3.8 1 0.5 1 0.5 1 0.5
18-19 131 1 0.8 9 6.9 2 1.5 1 0.8 . .
20-24 459 5 1.1 26 5.7 5 1.1 10 2.2 9 2.0
25-29 534 6 1.1 24 4.6 7 1.3 8 1.5 5 0.9
30-34 441 6 1.4 32 7.4 18 4.1 14 3.2 10 2.3
35+ 210 4 1.9 19 9.1 7 3.3 9 4.3 8 3.9
Years since diagnosis 5-9 144 1 0.7 3 2.1 . . . . 1 0.7
10-14 673 7 1.1 31 4.7 11 1.7 9 1.4 8 1.2
15-19 684 8 1.2 48 7.1 13 1.9 21 3.1 10 1.5
20+ 486 7 1.5 36 7.5 16 3.3 13 2.7 14 2.9
Age at diagnosis <1 15 . . . . 1 6.7 . . . .
1-4 327 3 0.9 21 6.5 1 0.3 2 0.6 3 0.9
5-9 601 9 1.5 37 6.2 16 2.7 17 2.9 9 1.5
10-14 635 7 1.1 28 4.5 10 1.6 13 2.1 9 1.4
15-20 409 4 1.0 32 7.9 12 3.0 11 2.7 12 3.0
Treatment Surgery only 15 . . . . . . 1 6.7 . .
Chemotherapy, no radiation 983 10 1.0 23 2.4 12 1.2 14 1.4 18 1.8
Radiation, no chemotherapy 37 . . 5 13.5 1 2.7 1 2.7 . .
Chemotherapy and radiation 759 10 1.3 80 10.7 24 3.2 21 2.8 13 1.7
Unknown 193 3 1.6 10 5.3 3 1.6 6 3.2 2 1.0
Males All cases 1346 12 0.9 62 4.7 12 0.9 16 1.2 14 1.0
Age at baseline <18 146 1 0.7 6 4.1 . . . . 1 0.7
18-19 96 . . 6 6.3 1 1.1 . . . .
20-24 298 2 0.7 12 4.1 . . 1 0.3 3 1.0
25-29 379 5 1.3 11 2.9 1 0.3 5 1.3 1 0.3
30-34 288 2 0.7 12 4.2 6 2.1 5 1.8 5 1.8
35+ 139 2 1.4 15 10.8 4 2.9 5 3.6 4 2.9
Years since diagnosis 5-9 109 1 0.9 2 1.8 . . . . 1 0.9
10-14 458 3 0.7 15 3.3 3 0.7 4 0.9 4 0.9
15-19 445 5 1.1 23 5.2 5 1.1 8 1.8 2 0.5
20+ 334 3 0.9 22 6.7 4 1.2 4 1.2 7 2.1
Age at diagnosis <1 5 . . . . . . . . . .
1-4 221 2 0.9 14 6.4 . . . . . .
5-9 421 3 0.7 17 4.1 3 0.7 4 1.0 4 1.0
10-14 431 4 0.9 15 3.5 2 0.5 5 1.2 4 0.9
15-20 268 3 1.1 16 6.0 7 2.6 7 2.6 6 2.3
Treatment Surgery only 12 . . . . . . 1 8.3 . .
Chemotherapy, no radiation 663 6 0.9 8 1.2 3 0.5 4 0.6 8 1.2
Radiation, no chemotherapy 28 . . 5 17.9 1 3.6 1 3.6 . .
Chemotherapy and radiation 506 5 1.0 42 8.4 8 1.6 8 1.6 6 1.2
Unknown 137 1 0.7 7 5.2 . . 2 1.5 . .
Females All cases 641 11 1.7 56 8.8 28 4.4 27 4.2 19 3.0
Age at baseline <18 66 . . 2 3.0 1 1.5 1 1.5 . .
18-19 35 1 2.9 3 8.6 1 2.9 1 2.9 . .
20-24 161 3 1.9 14 8.8 5 3.1 9 5.7 6 3.8
CCSS data from Dec2010 and March 2015 data freeze 1 N and % based on response of 'Yes' 2 'Any hormonal problem' is based on a response of 'Yes' to one or more of the listed hormonal problems
Hormonal systems: NHL 34
Diabetes- pills
(E.6/E.6) 1
Diabetes- insulin
(E.7/E.7) 1
Growth hormone deficiency (E.8/E.8) 1
Osteoporosis (E.10/E.10) 1
Any hormonal problem2
All cases N % N % N % N % N %
Both sexes All cases 1987 23 1.2 36 1.8 62 3.2 51 2.6 303 15.7
Age at baseline <18 212 . . 2 0.9 13 6.1 4 1.9 27 13.0
18-19 131 . . 1 0.8 9 7.1 2 1.5 17 13.5
20-24 459 4 0.9 10 2.2 21 4.7 9 2.0 68 15.1
25-29 534 3 0.6 7 1.3 10 1.9 19 3.6 70 13.4
30-34 441 8 1.9 10 2.3 8 1.9 10 2.3 75 17.6
35+ 210 8 3.9 6 2.9 1 0.5 7 3.4 46 22.5
Years since diagnosis 5-9 144 . . 2 1.4 . . . . 7 5.0
10-14 673 4 0.6 12 1.8 18 2.7 19 2.9 90 13.8
15-19 684 7 1.0 10 1.5 30 4.5 24 3.5 121 18.1
20+ 486 12 2.5 12 2.5 14 2.9 8 1.7 85 18.1
Age at diagnosis <1 15 . . . . 2 13.3 . . 3 20.0
1-4 327 2 0.6 3 0.9 29 8.9 5 1.5 50 15.7
5-9 601 2 0.3 6 1.0 22 3.7 14 2.4 92 15.6
10-14 635 9 1.4 16 2.5 9 1.5 17 2.7 83 13.5
15-20 409 10 2.5 11 2.7 . . 15 3.7 75 18.9
Treatment Surgery only 15 . . . . . . . . 1 6.7
Chemotherapy, no radiation 983 14 1.4 19 1.9 11 1.1 25 2.6 108 11.3
Radiation, no chemotherapy 37 . . 1 2.7 . . 3 8.1 10 28.6
Chemotherapy and radiation 759 8 1.1 13 1.7 47 6.4 20 2.7 157 21.4
Unknown 193 1 0.5 3 1.6 4 2.1 3 1.6 27 14.2
Males All cases 1346 13 1.0 20 1.5 40 3.0 24 1.8 162 12.4
Age at baseline <18 146 . . . . 9 6.2 3 2.1 17 12.1
18-19 96 . . 1 1.0 4 4.3 2 2.1 10 10.9
20-24 298 2 0.7 3 1.0 16 5.4 4 1.4 32 10.9
25-29 379 1 0.3 4 1.1 6 1.6 9 2.4 38 10.3
30-34 288 6 2.2 9 3.2 5 1.8 4 1.4 39 14.1
35+ 139 4 2.9 3 2.2 . . 2 1.4 26 19.1
Years since diagnosis 5-9 109 . . . . . . . . 4 3.7
10-14 458 3 0.7 5 1.1 13 2.9 9 2.0 46 10.4
15-19 445 3 0.7 6 1.4 19 4.4 12 2.7 64 14.7
20+ 334 7 2.2 9 2.7 8 2.5 3 0.9 48 15.0
Age at diagnosis <1 5 . . . . . . . . . .
1-4 221 . . . . 20 9.1 4 1.8 30 14.1
5-9 421 . . 4 1.0 13 3.1 8 1.9 47 11.4
10-14 431 8 1.9 10 2.3 7 1.7 8 1.9 46 11.1
15-20 268 5 1.9 6 2.2 . . 4 1.5 39 15.0
Treatment Surgery only 12 . . . . . . . . 1 8.3
Chemotherapy, no radiation 663 8 1.2 9 1.4 8 1.2 13 2.0 51 7.9
Radiation, no chemotherapy 28 . . 1 3.6 . . 1 3.6 8 29.6
Chemotherapy and radiation 506 4 0.8 8 1.6 30 6.1 9 1.8 87 17.9
Unknown 137 1 0.7 2 1.5 2 1.5 1 0.7 15 11.2
Females All cases 641 10 1.6 16 2.5 22 3.5 27 4.2 141 22.5
Age at baseline <18 66 . . 2 3.0 4 6.1 1 1.5 10 15.2
18-19 35 . . . . 5 14.3 . . 7 20.6
20-24 161 2 1.3 7 4.4 5 3.2 5 3.1 36 22.9
CCSS data from Dec2010 and March 2015 data freeze 1 N and % based on response of 'Yes' 2 'Any hormonal problem' is based on a response of 'Yes' to one or more of the listed hormonal problems
Hormonal systems: NHL 35
Overactive thyroid
(E.1/E.1) 1
Underactive thyroid
(E.2/E.2) 1
Thyroid nodules (E.3/E.3) 1
Thyroid enlargement
(E.4/E.4) 1
Diabetes- diet (E.5/E.5)
1
All cases N % N % N % N % N %
25-29 155 1 0.6 13 8.4 6 3.9 3 1.9 4 2.6
30-34 153 4 2.6 20 13.2 12 7.9 9 5.9 5 3.3
35+ 71 2 2.9 4 5.7 3 4.3 4 5.7 4 5.8
Years since diagnosis 5-9 35 . . 1 2.9 . . . . . .
10-14 215 4 1.9 16 7.5 8 3.8 5 2.3 4 1.9
15-19 239 3 1.3 25 10.5 8 3.4 13 5.5 8 3.4
20+ 152 4 2.6 14 9.3 12 8.0 9 6.0 7 4.7
Age at diagnosis <1 10 . . . . 1 10.0 . . . .
1-4 106 1 0.9 7 6.6 1 1.0 2 1.9 3 2.8
5-9 180 6 3.3 20 11.2 13 7.2 13 7.2 5 2.8
10-14 204 3 1.5 13 6.4 8 3.9 8 4.0 5 2.5
15-20 141 1 0.7 16 11.5 5 3.6 4 2.9 6 4.3
Treatment Surgery only 3 . . . . . . . . . .
Chemotherapy, no radiation 320 4 1.3 15 4.7 9 2.8 10 3.2 10 3.1
Radiation, no chemotherapy 9 . . . . . . . . . .
Chemotherapy and radiation 253 5 2.0 38 15.1 16 6.4 13 5.2 7 2.8
Unknown 56 2 3.6 3 5.5 3 5.4 4 7.1 2 3.6
CCSS data from Dec2010 and March 2015 data freeze 1 N and % based on response of 'Yes' 2 'Any hormonal problem' is based on a response of 'Yes' to one or more of the listed hormonal problems
Hormonal systems: NHL 36
Diabetes- pills
(E.6/E.6) 1
Diabetes- insulin
(E.7/E.7) 1
Growth hormone deficiency (E.8/E.8) 1
Osteoporosis (E.10/E.10) 1
Any hormonal problem2
All cases N % N % N % N % N %
25-29 155 2 1.3 3 1.9 4 2.6 10 6.5 32 20.9
30-34 153 2 1.3 1 0.7 3 2.0 6 4.0 36 24.2
35+ 71 4 5.8 3 4.3 1 1.5 5 7.1 20 29.4
Years since diagnosis 5-9 35 . . 2 5.7 . . . . 3 9.1
10-14 215 1 0.5 7 3.3 5 2.4 10 4.7 44 20.9
15-19 239 4 1.7 4 1.7 11 4.6 12 5.1 57 24.3
20+ 152 5 3.3 3 2.0 6 4.0 5 3.3 37 25.0
Age at diagnosis <1 10 . . . . 2 20.0 . . 3 30.0
1-4 106 2 1.9 3 2.9 9 8.5 1 0.9 20 19.0
5-9 180 2 1.1 2 1.1 9 5.0 6 3.4 45 25.3
10-14 204 1 0.5 6 3.0 2 1.0 9 4.5 37 18.7
15-20 141 5 3.6 5 3.6 . . 11 7.9 36 26.5
Treatment Surgery only 3 . . . . . . . . . .
Chemotherapy, no radiation 320 6 1.9 10 3.1 3 0.9 12 3.8 57 18.2
Radiation, no chemotherapy 9 . . . . . . 2 22.2 2 25.0
Chemotherapy and radiation 253 4 1.6 5 2.0 17 6.9 11 4.4 70 28.3
Unknown 56 . . 1 1.8 2 3.6 2 3.6 12 21.4
CCSS data from Dec2010 and March 2015 data freeze 1 N and % based on response of 'Yes' 2 'Any hormonal problem' is based on a response of 'Yes' to one or more of the listed hormonal problems
Hormonal systems: Wilms 37
Overactive thyroid
(E.1/E.1) 1
Underactive thyroid
(E.2/E.2) 1
Thyroid nodules (E.3/E.3) 1
Thyroid enlargement
(E.4/E.4) 1
Diabetes- diet (E.5/E.5)
1
All cases N % N % N % N % N %
Both sexes All cases 2159 13 0.6 42 2.0 14 0.7 31 1.4 19 0.9
Age at baseline <18 825 4 0.5 9 1.1 4 0.5 3 0.4 3 0.4
18-19 297 3 1.0 5 1.7 1 0.3 4 1.3 . .
20-24 639 1 0.2 11 1.7 3 0.5 9 1.4 7 1.1
25-29 327 5 1.5 15 4.6 5 1.6 12 3.8 9 2.8
30-34 57 . . 2 3.5 1 1.8 2 3.5 . .
35+ 14 . . . . . . 1 7.1 . .
Years since diagnosis 5-9 175 1 0.6 1 0.6 . . . . . .
10-14 738 4 0.5 12 1.6 5 0.7 5 0.7 3 0.4
15-19 722 4 0.6 10 1.4 3 0.4 12 1.7 4 0.6
20+ 524 4 0.8 19 3.7 6 1.2 14 2.7 12 2.3
Age at diagnosis <1 313 1 0.3 6 1.9 . . 2 0.6 2 0.6
1-4 1326 5 0.4 20 1.5 9 0.7 17 1.3 13 1.0
5-9 444 7 1.6 14 3.2 5 1.1 9 2.0 3 0.7
10-14 53 . . 2 3.8 . . 2 3.8 1 1.9
15-20 23 . . . . . . 1 4.3 . .
Treatment Surgery only 31 . . . . . . . . . .
Chemotherapy, no radiation 804 2 0.2 6 0.8 . . 3 0.4 5 0.6
Radiation, no chemotherapy 4 . . . . . . . . . .
Chemotherapy and radiation 1117 11 1.0 33 3.0 13 1.2 26 2.3 13 1.2
Unknown 203 . . 3 1.5 1 0.5 2 1.0 1 0.5
Males All cases 970 2 0.2 11 1.1 3 0.3 7 0.7 6 0.6
Age at baseline <18 400 1 0.3 4 1.0 1 0.3 2 0.5 2 0.5
18-19 124 . . . . . . . . . .
20-24 271 . . 5 1.8 . . 2 0.7 2 0.7
25-29 146 1 0.7 2 1.4 2 1.4 3 2.1 2 1.4
30-34 24 . . . . . . . . . .
35+ 5 . . . . . . . . . .
Years since diagnosis 5-9 77 . . . . . . . . . .
10-14 334 1 0.3 4 1.2 1 0.3 2 0.6 1 0.3
15-19 321 . . 3 0.9 . . 1 0.3 2 0.6
20+ 238 1 0.4 4 1.7 2 0.9 4 1.7 3 1.3
Age at diagnosis <1 163 1 0.6 1 0.6 . . 1 0.6 2 1.2
1-4 597 . . 8 1.3 2 0.3 5 0.8 4 0.7
5-9 181 1 0.6 2 1.1 1 0.6 1 0.6 . .
10-14 20 . . . . . . . . . .
15-20 9 . . . . . . . . . .
Treatment Surgery only 17 . . . . . . . . . .
Chemotherapy, no radiation 370 1 0.3 . . . . . . 1 0.3
Chemotherapy and radiation 481 1 0.2 11 2.3 3 0.6 7 1.5 5 1.0
Unknown 102 . . . . . . . . . .
Females All cases 1189 11 0.9 31 2.6 11 0.9 24 2.0 13 1.1
Age at baseline <18 425 3 0.7 5 1.2 3 0.7 1 0.2 1 0.2
18-19 173 3 1.7 5 2.9 1 0.6 4 2.3 . .
20-24 368 1 0.3 6 1.6 3 0.8 7 1.9 5 1.4
25-29 181 4 2.2 13 7.3 3 1.7 9 5.1 7 3.9
CCSS data from Dec2010 and March 2015 data freeze 1 N and % based on response of 'Yes' 2 'Any hormonal problem' is based on a response of 'Yes' to one or more of the listed hormonal problems
Hormonal systems: Wilms 38
Diabetes- pills
(E.6/E.6) 1
Diabetes- insulin
(E.7/E.7) 1
Growth hormone deficiency (E.8/E.8) 1
Osteoporosis (E.10/E.10) 1
Any hormonal problem2
All cases N % N % N % N % N %
Both sexes All cases 2159 10 0.5 20 0.9 48 2.2 41 1.9 178 8.4
Age at baseline <18 825 1 0.1 4 0.5 16 1.9 10 1.2 42 5.2
18-19 297 . . 2 0.7 6 2.0 5 1.7 22 7.5
20-24 639 3 0.5 5 0.8 13 2.1 10 1.6 51 8.2
25-29 327 5 1.6 9 2.8 13 4.0 15 4.6 57 17.9
30-34 57 1 1.8 . . . . 1 1.8 5 8.8
35+ 14 . . . . . . . . 1 7.7
Years since diagnosis 5-9 175 . . . . 2 1.1 1 0.6 3 1.7
10-14 738 1 0.1 5 0.7 16 2.2 11 1.5 50 6.9
15-19 722 2 0.3 6 0.8 15 2.1 12 1.7 54 7.6
20+ 524 7 1.4 9 1.7 15 2.9 17 3.3 71 13.9
Age at diagnosis <1 313 . . 2 0.6 7 2.2 5 1.6 20 6.4
1-4 1326 7 0.5 12 0.9 27 2.1 23 1.7 101 7.8
5-9 444 3 0.7 6 1.4 14 3.2 12 2.7 51 11.7
10-14 53 . . . . . . 1 1.9 5 9.4
15-20 23 . . . . . . . . 1 4.5
Treatment Surgery only 31 . . . . 2 6.7 1 3.2 3 10.0
Chemotherapy, no radiation 804 . . 2 0.2 7 0.9 8 1.0 31 3.9
Radiation, no chemotherapy 4 . . . . . . . . . .
Chemotherapy and radiation 1117 9 0.8 16 1.4 35 3.2 29 2.6 132 12.0
Unknown 203 1 0.5 2 1.0 4 2.0 3 1.5 12 6.0
Males All cases 970 3 0.3 8 0.8 16 1.7 9 0.9 51 5.4
Age at baseline <18 400 1 0.3 2 0.5 6 1.5 3 0.8 17 4.3
18-19 124 . . . . 1 0.8 2 1.6 3 2.4
20-24 271 1 0.4 2 0.7 5 1.9 2 0.7 15 5.6
25-29 146 1 0.7 4 2.8 4 2.8 1 0.7 15 10.6
30-34 24 . . . . . . 1 4.2 1 4.2
35+ 5 . . . . . . . . . .
Years since diagnosis 5-9 77 . . . . . . . . . .
10-14 334 1 0.3 2 0.6 5 1.5 3 0.9 15 4.6
15-19 321 1 0.3 2 0.6 5 1.6 4 1.2 15 4.7
20+ 238 1 0.4 4 1.7 6 2.6 2 0.8 21 9.1
Age at diagnosis <1 163 . . 1 0.6 3 1.8 2 1.2 10 6.1
1-4 597 3 0.5 4 0.7 10 1.7 5 0.8 31 5.3
5-9 181 . . 3 1.7 3 1.7 2 1.1 10 5.6
10-14 20 . . . . . . . . . .
15-20 9 . . . . . . . . . .
Treatment Surgery only 17 . . . . 2 11.8 1 5.9 3 17.6
Chemotherapy, no radiation 370 . . 1 0.3 3 0.8 3 0.8 8 2.2
Chemotherapy and radiation 481 3 0.6 6 1.3 9 1.9 5 1.0 37 7.8
Unknown 102 . . 1 1.0 2 2.0 . . 3 3.0
Females All cases 1189 7 0.6 12 1.0 32 2.7 32 2.7 127 10.9
Age at baseline <18 425 . . 2 0.5 10 2.4 7 1.7 25 6.0
18-19 173 . . 2 1.2 5 2.9 3 1.7 19 11.0
20-24 368 2 0.5 3 0.8 8 2.2 8 2.2 36 10.1
25-29 181 4 2.2 5 2.8 9 5.0 14 7.8 42 23.6
CCSS data from Dec2010 and March 2015 data freeze 1 N and % based on response of 'Yes' 2 'Any hormonal problem' is based on a response of 'Yes' to one or more of the listed hormonal problems
Hormonal systems: Wilms 39
Overactive thyroid
(E.1/E.1) 1
Underactive thyroid
(E.2/E.2) 1
Thyroid nodules (E.3/E.3) 1
Thyroid enlargement
(E.4/E.4) 1
Diabetes- diet (E.5/E.5)
1
All cases N % N % N % N % N %
30-34 33 . . 2 6.1 1 3.0 2 6.1 . .
35+ 9 . . . . . . 1 11.1 . .
Years since diagnosis 5-9 98 1 1.0 1 1.0 . . . . . .
10-14 404 3 0.7 8 2.0 4 1.0 3 0.7 2 0.5
15-19 401 4 1.0 7 1.8 3 0.7 11 2.8 2 0.5
20+ 286 3 1.1 15 5.3 4 1.4 10 3.5 9 3.2
Age at diagnosis <1 150 . . 5 3.3 . . 1 0.7 . .
1-4 729 5 0.7 12 1.7 7 1.0 12 1.7 9 1.2
5-9 263 6 2.3 12 4.6 4 1.5 8 3.1 3 1.1
10-14 33 . . 2 6.1 . . 2 6.1 1 3.0
15-20 14 . . . . . . 1 7.1 . .
Treatment Surgery only 14 . . . . . . . . . .
Chemotherapy, no radiation 434 1 0.2 6 1.4 . . 3 0.7 4 0.9
Radiation, no chemotherapy 4 . . . . . . . . . .
Chemotherapy and radiation 636 10 1.6 22 3.5 10 1.6 19 3.0 8 1.3
Unknown 101 . . 3 3.0 1 1.0 2 2.0 1 1.0
CCSS data from Dec2010 and March 2015 data freeze 1 N and % based on response of 'Yes' 2 'Any hormonal problem' is based on a response of 'Yes' to one or more of the listed hormonal problems
Hormonal systems: Wilms 40
Diabetes- pills
(E.6/E.6) 1
Diabetes- insulin
(E.7/E.7) 1
Growth hormone deficiency (E.8/E.8) 1
Osteoporosis (E.10/E.10) 1
Any hormonal problem2
All cases N % N % N % N % N %
30-34 33 1 3.0 . . . . . . 4 12.1
35+ 9 . . . . . . . . 1 12.5
Years since diagnosis 5-9 98 . . . . 2 2.0 1 1.0 3 3.1
10-14 404 . . 3 0.7 11 2.7 8 2.0 35 8.8
15-19 401 1 0.3 4 1.0 10 2.5 8 2.0 39 9.9
20+ 286 6 2.1 5 1.8 9 3.2 15 5.3 50 18.0
Age at diagnosis <1 150 . . 1 0.7 4 2.7 3 2.0 10 6.7
1-4 729 4 0.6 8 1.1 17 2.4 18 2.5 70 9.8
5-9 263 3 1.1 3 1.1 11 4.2 10 3.8 41 15.9
10-14 33 . . . . . . 1 3.0 5 15.2
15-20 14 . . . . . . . . 1 7.7
Treatment Surgery only 14 . . . . . . . . . .
Chemotherapy, no radiation 434 . . 1 0.2 4 0.9 5 1.2 23 5.4
Radiation, no chemotherapy 4 . . . . . . . . . .
Chemotherapy and radiation 636 6 1.0 10 1.6 26 4.1 24 3.8 95 15.2
Unknown 101 1 1.0 1 1.0 2 2.0 3 3.0 9 9.1
CCSS data from Dec2010 and March 2015 data freeze 1 N and % based on response of 'Yes' 2 'Any hormonal problem' is based on a response of 'Yes' to one or more of the listed hormonal problems
Hormonal systems: Neuroblastoma 41
Overactive thyroid
(E.1/E.1) 1
Underactive thyroid
(E.2/E.2) 1
Thyroid nodules (E.3/E.3) 1
Thyroid enlargement
(E.4/E.4) 1
Diabetes- diet (E.5/E.5)
1
All cases N % N % N % N % N %
Both sexes All cases 1852 18 1.0 87 4.7 32 1.7 32 1.7 24 1.3
Age at baseline <18 942 4 0.4 34 3.6 9 1.0 11 1.2 3 0.3
18-19 228 3 1.3 11 4.8 . . 1 0.4 2 0.9
20-24 503 6 1.2 23 4.6 11 2.2 12 2.4 13 2.6
25-29 141 4 2.9 11 7.9 7 5.0 5 3.6 2 1.4
30-34 32 1 3.1 6 19.4 5 15.6 2 6.3 4 12.5
35+ 6 . . 2 33.3 . . 1 16.7 . .
Years since diagnosis 5-9 159 . . 5 3.1 . . 1 0.6 . .
10-14 606 4 0.7 28 4.6 5 0.8 8 1.3 3 0.5
15-19 607 5 0.8 25 4.2 9 1.5 10 1.7 6 1.0
20+ 480 9 1.9 29 6.1 18 3.8 13 2.7 15 3.1
Age at diagnosis <1 950 8 0.8 23 2.4 10 1.1 11 1.2 8 0.8
1-4 716 8 1.1 44 6.2 17 2.4 14 2.0 10 1.4
5-9 140 2 1.4 13 9.4 4 2.9 5 3.6 5 3.6
10-14 28 . . 6 21.4 . . 2 7.4 . .
15-20 18 . . 1 5.6 1 5.6 . . 1 5.6
Treatment Surgery only 514 2 0.4 4 0.8 2 0.4 4 0.8 4 0.8
Chemotherapy, no radiation 527 4 0.8 14 2.7 6 1.2 5 1.0 6 1.1
Radiation, no chemotherapy 138 . . 5 3.6 1 0.7 3 2.2 . .
Chemotherapy and radiation 510 11 2.2 58 11.5 19 3.7 16 3.1 13 2.6
Unknown 163 1 0.6 6 3.7 4 2.5 4 2.5 1 0.6
Males All cases 904 9 1.0 39 4.3 8 0.9 13 1.5 15 1.7
Age at baseline <18 469 3 0.6 15 3.2 3 0.6 6 1.3 3 0.6
18-19 100 2 2.0 9 9.0 . . 1 1.0 1 1.0
20-24 253 3 1.2 7 2.8 2 0.8 4 1.6 7 2.8
25-29 66 1 1.5 5 7.7 2 3.1 1 1.5 2 3.0
30-34 13 . . 1 7.7 1 7.7 . . 2 15.4
35+ 3 . . 2 66.7 . . 1 33.3 . .
Years since diagnosis 5-9 75 . . 2 2.7 . . 1 1.3 . .
10-14 302 3 1.0 15 5.0 2 0.7 5 1.7 2 0.7
15-19 288 4 1.4 11 3.8 2 0.7 4 1.4 4 1.4
20+ 239 2 0.8 11 4.6 4 1.7 3 1.3 9 3.8
Age at diagnosis <1 496 3 0.6 11 2.2 3 0.6 5 1.0 5 1.0
1-4 318 4 1.3 19 6.0 4 1.3 4 1.3 7 2.2
5-9 71 2 2.9 6 8.6 1 1.4 2 2.9 3 4.2
10-14 13 . . 2 15.4 . . 2 16.7 . .
15-20 6 . . 1 16.7 . . . . . .
Treatment Surgery only 248 1 0.4 1 0.4 . . 1 0.4 3 1.2
Chemotherapy, no radiation 262 2 0.8 7 2.7 2 0.8 2 0.8 3 1.1
Radiation, no chemotherapy 62 . . 1 1.6 . . . . . .
Chemotherapy and radiation 247 5 2.0 27 11.0 5 2.0 7 2.8 9 3.6
Unknown 85 1 1.2 3 3.5 1 1.2 3 3.5 . .
Females All cases 948 9 1.0 48 5.1 24 2.6 19 2.0 9 1.0
Age at baseline <18 473 1 0.2 19 4.1 6 1.3 5 1.1 . .
18-19 128 1 0.8 2 1.6 . . . . 1 0.8
20-24 250 3 1.2 16 6.5 9 3.6 8 3.2 6 2.4
CCSS data from Dec2010 and March 2015 data freeze 1 N and % based on response of 'Yes' 2 'Any hormonal problem' is based on a response of 'Yes' to one or more of the listed hormonal problems
Hormonal systems: Neuroblastoma 42
Diabetes- pills
(E.6/E.6) 1
Diabetes- insulin
(E.7/E.7) 1
Growth hormone deficiency (E.8/E.8) 1
Osteoporosis (E.10/E.10) 1
Any hormonal problem2
All cases N % N % N % N % N %
Both sexes All cases 1852 19 1.0 24 1.3 112 6.1 48 2.6 257 14.2
Age at baseline <18 942 2 0.2 5 0.5 57 6.1 17 1.8 100 10.8
18-19 228 1 0.4 4 1.8 11 4.9 7 3.1 31 13.9
20-24 503 10 2.0 10 2.0 30 6.1 18 3.6 83 17.0
25-29 141 4 2.9 3 2.1 12 8.8 5 3.6 31 22.8
30-34 32 2 6.7 2 6.3 2 6.7 1 3.1 10 33.3
35+ 6 . . . . . . . . 2 33.3
Years since diagnosis 5-9 159 . . 1 0.6 11 7.0 8 5.1 21 13.5
10-14 606 1 0.2 6 1.0 41 6.8 12 2.0 76 12.7
15-19 607 6 1.0 5 0.8 33 5.5 15 2.5 76 12.9
20+ 480 12 2.5 12 2.5 27 5.8 13 2.7 84 18.0
Age at diagnosis <1 950 4 0.4 6 0.6 19 2.0 9 1.0 79 8.5
1-4 716 9 1.3 13 1.8 73 10.4 30 4.2 129 18.5
5-9 140 6 4.3 4 2.9 18 13.0 9 6.4 38 27.7
10-14 28 . . . . 2 7.7 . . 7 26.9
15-20 18 . . 1 5.6 . . . . 4 23.5
Treatment Surgery only 514 3 0.6 2 0.4 3 0.6 2 0.4 19 3.8
Chemotherapy, no radiation 527 1 0.2 2 0.4 15 2.9 9 1.7 48 9.2
Radiation, no chemotherapy 138 . . 1 0.7 6 4.7 2 1.5 13 10.4
Chemotherapy and radiation 510 15 3.0 15 3.0 82 16.3 33 6.5 161 32.1
Unknown 163 . . 4 2.5 6 3.7 2 1.2 16 9.9
Males All cases 904 13 1.5 14 1.6 51 5.7 16 1.8 112 12.7
Age at baseline <18 469 1 0.2 2 0.4 30 6.5 8 1.7 51 11.0
18-19 100 . . 3 3.0 6 6.1 2 2.0 16 16.3
20-24 253 6 2.4 7 2.8 10 4.1 5 2.0 29 11.8
25-29 66 4 6.3 1 1.5 4 6.3 1 1.6 12 19.0
30-34 13 2 16.7 1 7.7 1 8.3 . . 2 16.7
35+ 3 . . . . . . . . 2 66.7
Years since diagnosis 5-9 75 . . . . 7 9.5 5 6.7 12 16.2
10-14 302 1 0.3 4 1.3 20 6.7 4 1.3 37 12.5
15-19 288 2 0.7 3 1.0 16 5.7 4 1.4 32 11.4
20+ 239 10 4.3 7 2.9 8 3.4 3 1.3 31 13.3
Age at diagnosis <1 496 3 0.6 5 1.0 12 2.5 4 0.8 38 7.8
1-4 318 5 1.6 6 1.9 26 8.3 8 2.5 50 16.1
5-9 71 5 7.2 3 4.2 12 17.4 4 5.6 21 30.9
10-14 13 . . . . 1 9.1 . . 2 18.2
15-20 6 . . . . . . . . 1 16.7
Treatment Surgery only 248 2 0.8 2 0.8 2 0.8 . . 8 3.3
Chemotherapy, no radiation 262 1 0.4 1 0.4 9 3.5 3 1.1 24 9.3
Radiation, no chemotherapy 62 . . . . . . . . 1 1.8
Chemotherapy and radiation 247 10 4.1 10 4.1 36 14.8 12 4.9 71 29.2
Unknown 85 . . 1 1.2 4 4.7 1 1.2 8 9.4
Females All cases 948 6 0.6 10 1.1 61 6.5 32 3.4 145 15.7
Age at baseline <18 473 1 0.2 3 0.6 27 5.8 9 1.9 49 10.6
18-19 128 1 0.8 1 0.8 5 3.9 5 3.9 15 12.0
20-24 250 4 1.6 3 1.2 20 8.2 13 5.2 54 22.1
CCSS data from Dec2010 and March 2015 data freeze 1 N and % based on response of 'Yes' 2 'Any hormonal problem' is based on a response of 'Yes' to one or more of the listed hormonal problems
Hormonal systems: Neuroblastoma 43
Overactive thyroid
(E.1/E.1) 1
Underactive thyroid
(E.2/E.2) 1
Thyroid nodules (E.3/E.3) 1
Thyroid enlargement
(E.4/E.4) 1
Diabetes- diet (E.5/E.5)
1
All cases N % N % N % N % N %
25-29 75 3 4.1 6 8.1 5 6.7 4 5.3 . .
30-34 19 1 5.3 5 27.8 4 21.1 2 10.5 2 10.5
35+ 3 . . . . . . . . . .
Years since diagnosis 5-9 84 . . 3 3.6 . . . . . .
10-14 304 1 0.3 13 4.3 3 1.0 3 1.0 1 0.3
15-19 319 1 0.3 14 4.4 7 2.2 6 1.9 2 0.6
20+ 241 7 2.9 18 7.6 14 5.9 10 4.2 6 2.5
Age at diagnosis <1 454 5 1.1 12 2.7 7 1.6 6 1.3 3 0.7
1-4 398 4 1.0 25 6.4 13 3.3 10 2.5 3 0.8
5-9 69 . . 7 10.1 3 4.3 3 4.3 2 2.9
10-14 15 . . 4 26.7 . . . . . .
15-20 12 . . . . 1 8.3 . . 1 8.3
Treatment Surgery only 266 1 0.4 3 1.1 2 0.8 3 1.1 1 0.4
Chemotherapy, no radiation 265 2 0.8 7 2.7 4 1.5 3 1.1 3 1.1
Radiation, no chemotherapy 76 . . 4 5.3 1 1.4 3 4.0 . .
Chemotherapy and radiation 263 6 2.3 31 12.0 14 5.3 9 3.4 4 1.5
Unknown 78 . . 3 3.8 3 3.8 1 1.3 1 1.3
CCSS data from Dec2010 and March 2015 data freeze 1 N and % based on response of 'Yes' 2 'Any hormonal problem' is based on a response of 'Yes' to one or more of the listed hormonal problems
Hormonal systems: Neuroblastoma 44
Diabetes- pills
(E.6/E.6) 1
Diabetes- insulin
(E.7/E.7) 1
Growth hormone deficiency (E.8/E.8) 1
Osteoporosis (E.10/E.10) 1
Any hormonal problem2
All cases N % N % N % N % N %
25-29 75 . . 2 2.7 8 11.0 4 5.3 19 26.0
30-34 19 . . 1 5.3 1 5.6 1 5.3 8 44.4
35+ 3 . . . . . . . . . .
Years since diagnosis 5-9 84 . . 1 1.2 4 4.8 3 3.6 9 11.0
10-14 304 . . 2 0.7 21 7.0 8 2.6 39 13.0
15-19 319 4 1.3 2 0.6 17 5.4 11 3.5 44 14.2
20+ 241 2 0.8 5 2.1 19 8.1 10 4.2 53 22.6
Age at diagnosis <1 454 1 0.2 1 0.2 7 1.6 5 1.1 41 9.2
1-4 398 4 1.0 7 1.8 47 12.1 22 5.6 79 20.5
5-9 69 1 1.4 1 1.4 6 8.7 5 7.2 17 24.6
10-14 15 . . . . 1 6.7 . . 5 33.3
15-20 12 . . 1 8.3 . . . . 3 27.3
Treatment Surgery only 266 1 0.4 . . 1 0.4 2 0.8 11 4.2
Chemotherapy, no radiation 265 . . 1 0.4 6 2.3 6 2.3 24 9.2
Radiation, no chemotherapy 76 . . 1 1.3 6 8.3 2 2.7 12 17.1
Chemotherapy and radiation 263 5 1.9 5 1.9 46 17.7 21 8.0 90 34.9
Unknown 78 . . 3 3.8 2 2.6 1 1.3 8 10.4
CCSS data from Dec2010 and March 2015 data freeze 1 N and % based on response of 'Yes' 2 'Any hormonal problem' is based on a response of 'Yes' to one or more of the listed hormonal problems
Hormonal systems: STS 45
Overactive thyroid
(E.1/E.1) 1
Underactive thyroid
(E.2/E.2) 1
Thyroid nodules (E.3/E.3) 1
Thyroid enlargement
(E.4/E.4) 1
Diabetes- diet (E.5/E.5)
1
All cases N % N % N % N % N %
Both sexes All cases 1706 23 1.4 125 7.4 21 1.2 31 1.8 11 0.6
Age at baseline <18 339 4 1.2 20 5.9 3 0.9 6 1.8 . .
18-19 122 1 0.8 10 8.4 3 2.5 . . 1 0.8
20-24 412 3 0.7 32 7.8 5 1.2 10 2.5 1 0.2
25-29 377 7 1.9 33 8.8 3 0.8 6 1.6 4 1.1
30-34 282 8 2.8 22 7.9 6 2.1 5 1.8 2 0.7
35+ 174 . . 8 4.6 1 0.6 4 2.3 3 1.7
Years since diagnosis 5-9 181 2 1.1 7 3.9 . . . . 1 0.6
10-14 521 7 1.4 40 7.7 7 1.4 10 1.9 2 0.4
15-19 525 9 1.7 28 5.4 6 1.2 8 1.5 5 1.0
20+ 479 5 1.1 50 10.5 8 1.7 13 2.7 3 0.6
Age at diagnosis <1 119 . . 3 2.5 1 0.8 1 0.9 . .
1-4 535 7 1.3 46 8.7 8 1.5 13 2.5 1 0.2
5-9 387 3 0.8 38 9.9 7 1.8 6 1.6 2 0.5
10-14 338 8 2.4 26 7.7 3 0.9 5 1.5 2 0.6
15-20 327 5 1.5 12 3.7 2 0.6 6 1.8 6 1.8
Treatment Surgery only 167 1 0.6 2 1.2 . . 1 0.6 1 0.6
Chemotherapy, no radiation 346 2 0.6 5 1.5 1 0.3 1 0.3 2 0.6
Radiation, no chemotherapy 60 2 3.3 3 5.0 2 3.3 . . . .
Chemotherapy and radiation 959 16 1.7 109 11.5 17 1.8 28 2.9 6 0.6
Unknown 174 2 1.2 6 3.5 1 0.6 1 0.6 2 1.1
Males All cases 922 11 1.2 53 5.8 8 0.9 10 1.1 4 0.4
Age at baseline <18 191 3 1.6 9 4.7 2 1.1 2 1.0 . .
18-19 66 . . 4 6.3 3 4.8 . . 1 1.5
20-24 233 1 0.4 15 6.5 2 0.9 4 1.7 . .
25-29 199 2 1.0 15 7.6 . . 2 1.0 1 0.5
30-34 150 5 3.3 9 6.0 1 0.7 1 0.7 1 0.7
35+ 83 . . 1 1.2 . . 1 1.2 1 1.2
Years since diagnosis 5-9 100 1 1.0 3 3.0 . . . . . .
10-14 288 5 1.7 18 6.3 6 2.1 5 1.7 1 0.3
15-19 271 3 1.1 12 4.5 1 0.4 2 0.7 2 0.7
20+ 263 2 0.8 20 7.6 1 0.4 3 1.2 1 0.4
Age at diagnosis <1 51 . . . . . . . . . .
1-4 318 4 1.3 26 8.3 4 1.3 4 1.3 1 0.3
5-9 216 . . 12 5.6 4 1.9 2 0.9 . .
10-14 181 4 2.2 13 7.2 . . 2 1.1 1 0.6
15-20 156 3 1.9 2 1.3 . . 2 1.3 2 1.3
Treatment Surgery only 74 1 1.4 . . . . . . 1 1.4
Chemotherapy, no radiation 201 1 0.5 3 1.5 . . . . 1 0.5
Radiation, no chemotherapy 30 1 3.3 . . 1 3.3 . . . .
Chemotherapy and radiation 515 7 1.4 49 9.6 7 1.4 10 2.0 2 0.4
Unknown 102 1 1.0 1 1.0 . . . . . .
Females All cases 784 12 1.5 72 9.2 13 1.7 21 2.7 7 0.9
Age at baseline <18 148 1 0.7 11 7.4 1 0.7 4 2.8 . .
18-19 56 1 1.8 6 10.9 . . . . . .
20-24 179 2 1.1 17 9.7 3 1.7 6 3.4 1 0.6
CCSS data from Dec2010 and March 2015 data freeze 1 N and % based on response of 'Yes' 2 'Any hormonal problem' is based on a response of 'Yes' to one or more of the listed hormonal problems
Hormonal systems: STS 46
Diabetes- pills
(E.6/E.6) 1
Diabetes- insulin
(E.7/E.7) 1
Growth hormone deficiency (E.8/E.8) 1
Osteoporosis (E.10/E.10) 1
Any hormonal problem2
All cases N % N % N % N % N %
Both sexes All cases 1706 3 0.2 11 0.6 170 10.2 68 4.0 331 19.9
Age at baseline <18 339 . . 1 0.3 52 15.3 14 4.1 69 20.6
18-19 122 . . . . 17 14.4 6 5.0 28 23.7
20-24 412 . . 1 0.2 51 12.8 18 4.4 86 21.6
25-29 377 1 0.3 4 1.1 40 10.9 18 4.8 81 22.1
30-34 282 . . 3 1.1 9 3.2 5 1.8 46 16.6
35+ 174 2 1.2 2 1.2 1 0.6 7 4.1 21 12.4
Years since diagnosis 5-9 181 . . 1 0.6 18 10.3 8 4.4 30 17.1
10-14 521 . . 5 1.0 63 12.3 24 4.7 110 21.5
15-19 525 1 0.2 1 0.2 43 8.4 20 3.9 93 18.2
20+ 479 2 0.4 4 0.8 46 9.7 16 3.4 98 20.9
Age at diagnosis <1 119 . . . . 6 5.2 2 1.7 10 8.7
1-4 535 . . 1 0.2 86 16.3 22 4.1 124 23.7
5-9 387 . . 2 0.5 57 14.9 21 5.5 95 25.1
10-14 338 1 0.3 3 0.9 18 5.4 14 4.2 64 19.3
15-20 327 2 0.6 5 1.5 3 0.9 9 2.8 38 11.9
Treatment Surgery only 167 1 0.6 . . 2 1.2 1 0.6 8 5.0
Chemotherapy, no radiation 346 . . 1 0.3 3 0.9 6 1.8 16 4.7
Radiation, no chemotherapy 60 . . 2 3.3 1 1.8 1 1.7 9 15.5
Chemotherapy and radiation 959 1 0.1 6 0.6 154 16.4 49 5.2 270 28.8
Unknown 174 1 0.6 2 1.2 10 5.8 11 6.3 28 16.3
Males All cases 922 1 0.1 4 0.4 96 10.6 28 3.1 160 17.8
Age at baseline <18 191 . . 1 0.5 29 15.2 7 3.7 36 18.8
18-19 66 . . . . 10 15.6 3 4.5 15 23.1
20-24 233 . . 1 0.4 25 11.1 8 3.5 44 19.6
25-29 199 . . 2 1.0 26 13.2 7 3.6 40 20.5
30-34 150 . . . . 6 4.1 1 0.7 20 13.7
35+ 83 1 1.3 . . . . 2 2.4 5 6.3
Years since diagnosis 5-9 100 . . 1 1.0 11 11.6 6 6.0 18 18.8
10-14 288 . . 3 1.0 37 12.9 9 3.1 59 20.6
15-19 271 . . . . 21 8.0 8 3.0 39 14.9
20+ 263 1 0.4 . . 27 10.4 5 1.9 44 17.1
Age at diagnosis <1 51 . . . . 4 8.0 1 2.0 5 10.0
1-4 318 . . 1 0.3 46 14.7 11 3.5 65 20.8
5-9 216 . . . . 29 13.5 6 2.8 42 19.8
10-14 181 . . 2 1.1 15 8.5 7 3.9 35 19.9
15-20 156 1 0.7 1 0.6 2 1.3 3 1.9 13 8.7
Treatment Surgery only 74 1 1.4 . . 2 2.9 . . 4 5.8
Chemotherapy, no radiation 201 . . . . 3 1.5 3 1.5 8 4.1
Radiation, no chemotherapy 30 . . 1 3.3 . . 1 3.3 3 10.3
Chemotherapy and radiation 515 . . 2 0.4 84 16.6 21 4.1 133 26.2
Unknown 102 . . 1 1.0 7 6.9 3 2.9 12 12.0
Females All cases 784 2 0.3 7 0.9 74 9.6 40 5.1 171 22.4
Age at baseline <18 148 . . . . 23 15.5 7 4.8 33 22.9
18-19 56 . . . . 7 13.0 3 5.6 13 24.5
20-24 179 . . . . 26 14.9 10 5.6 42 24.0
CCSS data from Dec2010 and March 2015 data freeze 1 N and % based on response of 'Yes' 2 'Any hormonal problem' is based on a response of 'Yes' to one or more of the listed hormonal problems
Hormonal systems: STS 47
Overactive thyroid
(E.1/E.1) 1
Underactive thyroid
(E.2/E.2) 1
Thyroid nodules (E.3/E.3) 1
Thyroid enlargement
(E.4/E.4) 1
Diabetes- diet (E.5/E.5)
1
All cases N % N % N % N % N %
25-29 178 5 2.8 18 10.1 3 1.7 4 2.2 3 1.7
30-34 132 3 2.3 13 9.9 5 3.8 4 3.1 1 0.8
35+ 91 . . 7 7.7 1 1.1 3 3.3 2 2.2
Years since diagnosis 5-9 81 1 1.2 4 4.9 . . . . 1 1.2
10-14 233 2 0.9 22 9.5 1 0.4 5 2.2 1 0.4
15-19 254 6 2.4 16 6.3 5 2.0 6 2.4 3 1.2
20+ 216 3 1.4 30 14.0 7 3.3 10 4.6 2 0.9
Age at diagnosis <1 68 . . 3 4.5 1 1.5 1 1.5 . .
1-4 217 3 1.4 20 9.3 4 1.9 9 4.2 . .
5-9 171 3 1.8 26 15.4 3 1.8 4 2.4 2 1.2
10-14 157 4 2.5 13 8.3 3 1.9 3 1.9 1 0.6
15-20 171 2 1.2 10 5.8 2 1.2 4 2.3 4 2.3
Treatment Surgery only 93 . . 2 2.2 . . 1 1.1 . .
Chemotherapy, no radiation 145 1 0.7 2 1.4 1 0.7 1 0.7 1 0.7
Radiation, no chemotherapy 30 1 3.3 3 10.0 1 3.3 . . . .
Chemotherapy and radiation 444 9 2.0 60 13.6 10 2.3 18 4.1 4 0.9
Unknown 72 1 1.4 5 6.9 1 1.4 1 1.4 2 2.8
CCSS data from Dec2010 and March 2015 data freeze 1 N and % based on response of 'Yes' 2 'Any hormonal problem' is based on a response of 'Yes' to one or more of the listed hormonal problems
Hormonal systems: STS 48
Diabetes- pills
(E.6/E.6) 1
Diabetes- insulin
(E.7/E.7) 1
Growth hormone deficiency (E.8/E.8) 1
Osteoporosis (E.10/E.10) 1
Any hormonal problem2
All cases N % N % N % N % N %
25-29 178 1 0.6 2 1.1 14 8.2 11 6.2 41 23.8
30-34 132 . . 3 2.3 3 2.3 4 3.0 26 19.8
35+ 91 1 1.1 2 2.2 1 1.1 5 5.6 16 17.8
Years since diagnosis 5-9 81 . . . . 7 8.8 2 2.5 12 15.2
10-14 233 . . 2 0.9 26 11.4 15 6.5 51 22.6
15-19 254 1 0.4 1 0.4 22 8.8 12 4.8 54 21.7
20+ 216 1 0.5 4 1.9 19 9.0 11 5.1 54 25.6
Age at diagnosis <1 68 . . . . 2 3.0 1 1.5 5 7.7
1-4 217 . . . . 40 18.8 11 5.1 59 28.1
5-9 171 . . 2 1.2 28 16.7 15 8.9 53 31.9
10-14 157 1 0.6 1 0.6 3 1.9 7 4.5 29 18.7
15-20 171 1 0.6 4 2.3 1 0.6 6 3.5 25 14.8
Treatment Surgery only 93 . . . . . . 1 1.1 4 4.3
Chemotherapy, no radiation 145 . . 1 0.7 . . 3 2.1 8 5.6
Radiation, no chemotherapy 30 . . 1 3.3 1 3.7 . . 6 20.7
Chemotherapy and radiation 444 1 0.2 4 0.9 70 16.1 28 6.4 137 31.9
Unknown 72 1 1.4 1 1.4 3 4.2 8 11.1 16 22.2
CCSS data from Dec2010 and March 2015 data freeze 1 N and % based on response of 'Yes' 2 'Any hormonal problem' is based on a response of 'Yes' to one or more of the listed hormonal problems
Hormonal systems: All bone 49
Overactive thyroid
(E.1/E.1) 1
Underactive thyroid
(E.2/E.2) 1
Thyroid nodules (E.3/E.3) 1
Thyroid enlargement
(E.4/E.4) 1
Diabetes- diet (E.5/E.5)
1
All cases N % N % N % N % N %
Both sexes All cases 2017 20 1.0 67 3.3 29 1.4 32 1.6 18 0.9
Age at baseline <18 96 . . 2 2.1 . . . . . .
18-19 72 . . . . . . 1 1.4 . .
20-24 383 2 0.5 11 2.9 5 1.3 5 1.3 3 0.8
25-29 552 5 0.9 17 3.1 6 1.1 9 1.6 2 0.4
30-34 538 8 1.5 24 4.5 8 1.5 8 1.5 7 1.3
35+ 376 5 1.3 13 3.5 10 2.7 9 2.4 6 1.6
Years since diagnosis 5-9 241 1 0.4 5 2.1 . . 3 1.3 . .
10-14 676 6 0.9 23 3.4 7 1.0 9 1.3 6 0.9
15-19 641 7 1.1 20 3.1 9 1.4 10 1.6 5 0.8
20+ 459 6 1.3 19 4.2 13 2.8 10 2.2 7 1.5
Age at diagnosis <1 10 . . . . . . . . . .
1-4 83 1 1.3 5 6.3 3 3.8 1 1.3 . .
5-9 356 . . 10 2.8 4 1.1 4 1.1 1 0.3
10-14 805 11 1.4 25 3.1 10 1.2 11 1.4 10 1.2
15-20 763 8 1.1 27 3.6 12 1.6 16 2.1 7 0.9
Treatment Surgery only 116 2 1.7 3 2.6 1 0.9 2 1.7 1 0.9
Chemotherapy, no radiation 1127 11 1.0 36 3.2 17 1.5 22 2.0 14 1.2
Radiation, no chemotherapy 15 . . 1 6.7 1 6.7 1 6.7 . .
Chemotherapy and radiation 583 5 0.9 22 3.8 9 1.5 5 0.9 2 0.3
Unknown 176 2 1.1 5 2.8 1 0.6 2 1.1 1 0.6
Males All cases 1044 10 1.0 15 1.4 10 1.0 9 0.9 4 0.4
Age at baseline <18 48 . . 1 2.1 . . . . . .
18-19 36 . . . . . . . . . .
20-24 189 1 0.5 1 0.5 2 1.1 1 0.5 . .
25-29 293 2 0.7 6 2.1 3 1.0 3 1.0 . .
30-34 271 4 1.5 5 1.8 1 0.4 2 0.7 3 1.1
35+ 207 3 1.5 2 1.0 4 1.9 3 1.5 1 0.5
Years since diagnosis 5-9 132 . . 1 0.8 . . 1 0.8 . .
10-14 346 4 1.2 5 1.4 3 0.9 3 0.9 1 0.3
15-19 333 2 0.6 5 1.5 2 0.6 2 0.6 2 0.6
20+ 233 4 1.7 4 1.7 5 2.2 3 1.3 1 0.4
Age at diagnosis <1 4 . . . . . . . . . .
1-4 43 1 2.4 2 4.8 2 4.8 . . . .
5-9 185 . . 3 1.6 1 0.5 1 0.5 . .
10-14 385 3 0.8 4 1.0 2 0.5 2 0.5 . .
15-20 427 6 1.4 6 1.4 5 1.2 6 1.4 4 0.9
Treatment Surgery only 49 2 4.1 2 4.2 1 2.0 2 4.2 . .
Chemotherapy, no radiation 578 5 0.9 7 1.2 4 0.7 5 0.9 4 0.7
Radiation, no chemotherapy 7 . . 1 14.3 1 14.3 1 14.3 . .
Chemotherapy and radiation 299 2 0.7 4 1.3 4 1.3 1 0.3 . .
Unknown 111 1 0.9 1 0.9 . . . . . .
Females All cases 973 10 1.0 52 5.4 19 2.0 23 2.4 14 1.4
Age at baseline <18 48 . . 1 2.1 . . . . . .
18-19 36 . . . . . . 1 2.8 . .
20-24 194 1 0.5 10 5.2 3 1.6 4 2.1 3 1.5
CCSS data from Dec2010 and March 2015 data freeze 1 N and % based on response of 'Yes' 2 'Any hormonal problem' is based on a response of 'Yes' to one or more of the listed hormonal problems
Hormonal systems: All bone 50
Diabetes- pills
(E.6/E.6) 1
Diabetes- insulin
(E.7/E.7) 1
Growth hormone deficiency (E.8/E.8) 1
Osteoporosis (E.10/E.10) 1
Any hormonal problem2
All cases N % N % N % N % N %
Both sexes All cases 2017 15 0.8 16 0.8 24 1.2 116 5.8 260 13.3
Age at baseline <18 96 . . 1 1.1 5 5.3 5 5.3 12 12.6
18-19 72 . . . . 2 2.8 3 4.2 5 7.1
20-24 383 2 0.5 1 0.3 8 2.1 26 6.8 48 12.9
25-29 552 2 0.4 2 0.4 4 0.7 29 5.3 62 11.7
30-34 538 7 1.3 7 1.3 4 0.8 33 6.2 80 15.4
35+ 376 4 1.1 5 1.3 1 0.3 20 5.3 53 14.2
Years since diagnosis 5-9 241 1 0.4 1 0.4 3 1.3 10 4.1 20 8.7
10-14 676 4 0.6 3 0.4 9 1.4 38 5.7 83 12.6
15-19 641 7 1.1 6 0.9 6 0.9 33 5.2 77 12.3
20+ 459 3 0.7 6 1.3 6 1.3 35 7.7 80 17.9
Age at diagnosis <1 10 . . . . 2 20.0 1 10.0 2 20.0
1-4 83 . . . . 6 7.5 6 7.5 17 21.3
5-9 356 . . 1 0.3 7 2.0 24 6.8 41 11.7
10-14 805 8 1.0 9 1.1 7 0.9 46 5.7 105 13.4
15-20 763 7 0.9 6 0.8 2 0.3 39 5.1 95 12.8
Treatment Surgery only 116 . . 3 2.6 . . 2 1.7 10 9.0
Chemotherapy, no radiation 1127 14 1.3 11 1.0 4 0.4 58 5.2 137 12.5
Radiation, no chemotherapy 15 . . . . 1 6.7 . . 2 13.3
Chemotherapy and radiation 583 1 0.2 2 0.3 16 2.8 50 8.6 94 16.5
Unknown 176 . . . . 3 1.7 6 3.4 17 9.7
Males All cases 1044 3 0.3 8 0.8 11 1.1 39 3.8 91 9.0
Age at baseline <18 48 . . 1 2.1 3 6.3 2 4.2 7 14.6
18-19 36 . . . . . . 2 5.6 2 5.7
20-24 189 . . 1 0.5 2 1.1 6 3.2 13 7.1
25-29 293 . . . . 2 0.7 11 3.8 24 8.6
30-34 271 2 0.7 2 0.7 3 1.1 9 3.4 23 8.7
35+ 207 1 0.5 4 1.9 1 0.5 9 4.3 22 10.7
Years since diagnosis 5-9 132 . . 1 0.8 1 0.8 3 2.3 7 5.6
10-14 346 . . 1 0.3 3 0.9 13 3.8 29 8.7
15-19 333 3 0.9 2 0.6 4 1.2 10 3.0 27 8.3
20+ 233 . . 4 1.7 3 1.3 13 5.6 28 12.2
Age at diagnosis <1 4 . . . . 1 25.0 . . 1 25.0
1-4 43 . . . . 2 4.8 3 7.1 8 19.0
5-9 185 . . . . 4 2.2 7 3.8 14 7.7
10-14 385 1 0.3 4 1.0 2 0.5 15 3.9 29 7.7
15-20 427 2 0.5 4 0.9 2 0.5 14 3.3 39 9.4
Treatment Surgery only 49 . . 2 4.1 . . 2 4.1 8 16.7
Chemotherapy, no radiation 578 3 0.5 4 0.7 3 0.5 18 3.1 44 7.9
Radiation, no chemotherapy 7 . . . . 1 14.3 . . 2 28.6
Chemotherapy and radiation 299 . . 2 0.7 6 2.1 16 5.4 32 11.1
Unknown 111 . . . . 1 0.9 3 2.7 5 4.5
Females All cases 973 12 1.3 8 0.8 13 1.4 77 8.0 169 17.8
Age at baseline <18 48 . . . . 2 4.3 3 6.4 5 10.6
18-19 36 . . . . 2 5.6 1 2.8 3 8.6
20-24 194 2 1.0 . . 6 3.1 20 10.3 35 18.5
CCSS data from Dec2010 and March 2015 data freeze 1 N and % based on response of 'Yes' 2 'Any hormonal problem' is based on a response of 'Yes' to one or more of the listed hormonal problems
Hormonal systems: All bone 51
Overactive thyroid
(E.1/E.1) 1
Underactive thyroid
(E.2/E.2) 1
Thyroid nodules (E.3/E.3) 1
Thyroid enlargement
(E.4/E.4) 1
Diabetes- diet (E.5/E.5)
1
All cases N % N % N % N % N %
25-29 259 3 1.2 11 4.3 3 1.2 6 2.3 2 0.8
30-34 267 4 1.5 19 7.2 7 2.6 6 2.3 4 1.5
35+ 169 2 1.2 11 6.5 6 3.6 6 3.6 5 3.0
Years since diagnosis 5-9 109 1 0.9 4 3.7 . . 2 1.9 . .
10-14 330 2 0.6 18 5.5 4 1.2 6 1.8 5 1.5
15-19 308 5 1.6 15 4.9 7 2.3 8 2.6 3 1.0
20+ 226 2 0.9 15 6.7 8 3.6 7 3.1 6 2.7
Age at diagnosis <1 6 . . . . . . . . . .
1-4 40 . . 3 7.9 1 2.6 1 2.6 . .
5-9 171 . . 7 4.1 3 1.8 3 1.8 1 0.6
10-14 420 8 1.9 21 5.0 8 1.9 9 2.2 10 2.4
15-20 336 2 0.6 21 6.3 7 2.1 10 3.0 3 0.9
Treatment Surgery only 67 . . 1 1.5 . . . . 1 1.5
Chemotherapy, no radiation 549 6 1.1 29 5.3 13 2.4 17 3.1 10 1.8
Radiation, no chemotherapy 8 . . . . . . . . . .
Chemotherapy and radiation 284 3 1.1 18 6.3 5 1.8 4 1.4 2 0.7
Unknown 65 1 1.5 4 6.2 1 1.5 2 3.1 1 1.5
CCSS data from Dec2010 and March 2015 data freeze 1 N and % based on response of 'Yes' 2 'Any hormonal problem' is based on a response of 'Yes' to one or more of the listed hormonal problems
Hormonal systems: All bone 52
Diabetes- pills
(E.6/E.6) 1
Diabetes- insulin
(E.7/E.7) 1
Growth hormone deficiency (E.8/E.8) 1
Osteoporosis (E.10/E.10) 1
Any hormonal problem2
All cases N % N % N % N % N %
25-29 259 2 0.8 2 0.8 2 0.8 18 7.0 38 15.0
30-34 267 5 1.9 5 1.9 1 0.4 24 9.1 57 22.3
35+ 169 3 1.8 1 0.6 . . 11 6.5 31 18.6
Years since diagnosis 5-9 109 1 1.0 . . 2 1.9 7 6.4 13 12.3
10-14 330 4 1.2 2 0.6 6 1.8 25 7.6 54 16.8
15-19 308 4 1.3 4 1.3 2 0.7 23 7.5 50 16.7
20+ 226 3 1.3 2 0.9 3 1.4 22 9.8 52 23.7
Age at diagnosis <1 6 . . . . 1 16.7 1 16.7 1 16.7
1-4 40 . . . . 4 10.5 3 7.9 9 23.7
5-9 171 . . 1 0.6 3 1.8 17 10.0 27 16.1
10-14 420 7 1.7 5 1.2 5 1.2 31 7.4 76 18.6
15-20 336 5 1.5 2 0.6 . . 25 7.5 56 17.1
Treatment Surgery only 67 . . 1 1.5 . . . . 2 3.2
Chemotherapy, no radiation 549 11 2.0 7 1.3 1 0.2 40 7.4 93 17.5
Radiation, no chemotherapy 8 . . . . . . . . . .
Chemotherapy and radiation 284 1 0.4 . . 10 3.6 34 12.0 62 22.2
Unknown 65 . . . . 2 3.1 3 4.6 12 18.5
CCSS data from Dec2010 and March 2015 data freeze 1 N and % based on response of 'Yes' 2 'Any hormonal problem' is based on a response of 'Yes' to one or more of the listed hormonal problems
Hormonal systems: Ewings 53
Overactive thyroid
(E.1/E.1) 1
Underactive thyroid
(E.2/E.2) 1
Thyroid nodules (E.3/E.3) 1
Thyroid enlargement
(E.4/E.4) 1
Diabetes- diet (E.5/E.5)
1
All cases N % N % N % N % N %
Both sexes All cases 714 8 1.1 27 3.8 12 1.7 8 1.1 3 0.4
Age at baseline <18 61 . . . . . . . . . .
18-19 36 . . . . . . 1 2.8 . .
20-24 168 1 0.6 5 3.0 3 1.8 2 1.2 2 1.2
25-29 199 3 1.5 5 2.5 2 1.0 2 1.0 . .
30-34 155 3 1.9 12 7.7 1 0.6 . . . .
35+ 95 1 1.1 5 5.3 6 6.3 3 3.2 1 1.1
Years since diagnosis 5-9 103 . . 1 1.0 . . 2 2.0 . .
10-14 245 3 1.2 6 2.5 1 0.4 . . 2 0.8
15-19 213 4 1.9 9 4.2 5 2.3 3 1.4 . .
20+ 153 1 0.7 11 7.3 6 3.9 3 2.0 1 0.7
Age at diagnosis <1 5 . . . . . . . . . .
1-4 52 . . 2 4.0 2 4.0 1 2.0 . .
5-9 181 . . 7 3.9 3 1.7 2 1.1 1 0.6
10-14 267 6 2.2 7 2.6 2 0.7 2 0.8 1 0.4
15-20 209 2 1.0 11 5.3 5 2.4 3 1.4 1 0.5
Treatment Surgery only 1 . . . . . . . . . .
Chemotherapy, no radiation 199 1 0.5 7 3.6 3 1.5 2 1.0 1 0.5
Radiation, no chemotherapy 2 . . . . . . . . . .
Chemotherapy and radiation 457 5 1.1 18 3.9 8 1.8 5 1.1 2 0.4
Unknown 55 2 3.6 2 3.6 1 1.8 1 1.8 . .
Males All cases 371 4 1.1 6 1.6 4 1.1 1 0.3 1 0.3
Age at baseline <18 27 . . . . . . . . . .
18-19 20 . . . . . . . . . .
20-24 85 1 1.2 . . 1 1.2 . . . .
25-29 102 . . 2 2.0 1 1.0 1 1.0 . .
30-34 85 2 2.4 3 3.5 . . . . . .
35+ 52 1 2.0 1 2.0 2 3.8 . . 1 1.9
Years since diagnosis 5-9 55 . . . . . . 1 1.8 . .
10-14 119 1 0.8 . . . . . . . .
15-19 117 2 1.7 3 2.6 2 1.7 . . . .
20+ 80 1 1.3 3 3.8 2 2.5 . . 1 1.3
Age at diagnosis <1 2 . . . . . . . . . .
1-4 27 . . . . 1 3.8 . . . .
5-9 90 . . 3 3.3 1 1.1 . . . .
10-14 141 3 2.1 1 0.7 1 0.7 . . . .
15-20 111 1 0.9 2 1.8 1 0.9 1 0.9 1 0.9
Treatment Chemotherapy, no radiation 104 1 1.0 2 1.9 . . . . 1 1.0
Radiation, no chemotherapy 1 . . . . . . . . . .
Chemotherapy and radiation 233 2 0.9 4 1.7 4 1.7 1 0.4 . .
Unknown 33 1 3.0 . . . . . . . .
Females All cases 343 4 1.2 21 6.2 8 2.3 7 2.1 2 0.6
Age at baseline <18 34 . . . . . . . . . .
18-19 16 . . . . . . 1 6.3 . .
20-24 83 . . 5 6.1 2 2.4 2 2.5 2 2.4
25-29 97 3 3.1 3 3.1 1 1.0 1 1.0 . .
CCSS data from Dec2010 and March 2015 data freeze 1 N and % based on response of 'Yes' 2 'Any hormonal problem' is based on a response of 'Yes' to one or more of the listed hormonal problems
Hormonal systems: Ewings 54
Diabetes- pills
(E.6/E.6) 1
Diabetes- insulin
(E.7/E.7) 1
Growth hormone deficiency (E.8/E.8) 1
Osteoporosis (E.10/E.10) 1
Any hormonal problem2
All cases N % N % N % N % N %
Both sexes All cases 714 3 0.4 4 0.6 15 2.1 48 6.8 104 15.0
Age at baseline <18 61 . . . . 4 6.7 3 5.0 6 10.0
18-19 36 . . . . 1 2.8 2 5.6 3 8.6
20-24 168 . . 1 0.6 6 3.6 12 7.1 25 15.2
25-29 199 1 0.5 . . 1 0.5 14 7.1 26 13.5
30-34 155 2 1.3 1 0.6 3 2.0 11 7.1 27 18.1
35+ 95 . . 2 2.1 . . 6 6.3 17 18.1
Years since diagnosis 5-9 103 . . . . 3 3.0 4 3.9 9 8.9
10-14 245 1 0.4 1 0.4 6 2.5 16 6.6 31 13.1
15-19 213 2 1.0 1 0.5 2 1.0 12 5.7 28 13.5
20+ 153 . . 2 1.3 4 2.6 16 10.5 36 24.0
Age at diagnosis <1 5 . . . . 1 20.0 1 20.0 1 20.0
1-4 52 . . . . 3 6.0 4 8.0 10 20.0
5-9 181 . . . . 6 3.3 15 8.3 27 15.3
10-14 267 1 0.4 2 0.7 5 1.9 17 6.4 38 14.6
15-20 209 2 1.0 2 1.0 . . 11 5.3 28 13.9
Treatment Surgery only 1 . . . . . . . . . .
Chemotherapy, no radiation 199 2 1.0 3 1.5 . . 5 2.6 17 8.9
Radiation, no chemotherapy 2 . . . . . . . . . .
Chemotherapy and radiation 457 1 0.2 1 0.2 13 2.9 40 8.8 78 17.5
Unknown 55 . . . . 2 3.6 3 5.5 9 16.4
Males All cases 371 . . 3 0.8 5 1.4 14 3.8 34 9.4
Age at baseline <18 27 . . . . 2 7.4 1 3.7 3 11.1
18-19 20 . . . . . . 1 5.0 1 5.0
20-24 85 . . 1 1.2 1 1.2 2 2.4 6 7.1
25-29 102 . . . . . . 5 5.0 8 8.3
30-34 85 . . . . 2 2.4 3 3.6 9 11.0
35+ 52 . . 2 3.8 . . 2 3.8 7 13.7
Years since diagnosis 5-9 55 . . . . 1 1.9 1 1.8 3 5.6
10-14 119 . . 1 0.8 1 0.9 3 2.5 6 5.2
15-19 117 . . . . 1 0.9 5 4.3 12 10.6
20+ 80 . . 2 2.5 2 2.5 5 6.3 13 16.7
Age at diagnosis <1 2 . . . . . . . . . .
1-4 27 . . . . 1 3.8 2 7.7 4 15.4
5-9 90 . . . . 3 3.3 4 4.4 9 10.2
10-14 141 . . 1 0.7 1 0.7 7 5.0 14 10.1
15-20 111 . . 2 1.8 . . 1 0.9 7 6.5
Treatment Chemotherapy, no radiation 104 . . 2 1.9 . . . . 5 5.0
Radiation, no chemotherapy 1 . . . . . . . . . .
Chemotherapy and radiation 233 . . 1 0.4 5 2.2 13 5.6 27 11.9
Unknown 33 . . . . . . 1 3.0 2 6.1
Females All cases 343 3 0.9 1 0.3 10 3.0 34 9.9 70 21.0
Age at baseline <18 34 . . . . 2 6.1 2 6.1 3 9.1
18-19 16 . . . . 1 6.3 1 6.3 2 13.3
20-24 83 . . . . 5 6.1 10 12.0 19 23.8
25-29 97 1 1.0 . . 1 1.1 9 9.3 18 18.8
CCSS data from Dec2010 and March 2015 data freeze 1 N and % based on response of 'Yes' 2 'Any hormonal problem' is based on a response of 'Yes' to one or more of the listed hormonal problems
Hormonal systems: Ewings 55
Overactive thyroid
(E.1/E.1) 1
Underactive thyroid
(E.2/E.2) 1
Thyroid nodules (E.3/E.3) 1
Thyroid enlargement
(E.4/E.4) 1
Diabetes- diet (E.5/E.5)
1
All cases N % N % N % N % N %
30-34 70 1 1.4 9 12.9 1 1.4 . . . .
35+ 43 . . 4 9.3 4 9.3 3 7.0 . .
Years since diagnosis 5-9 48 . . 1 2.1 . . 1 2.1 . .
10-14 126 2 1.6 6 4.8 1 0.8 . . 2 1.6
15-19 96 2 2.1 6 6.3 3 3.1 3 3.1 . .
20+ 73 . . 8 11.0 4 5.5 3 4.1 . .
Age at diagnosis <1 3 . . . . . . . . . .
1-4 25 . . 2 8.3 1 4.2 1 4.2 . .
5-9 91 . . 4 4.4 2 2.2 2 2.2 1 1.1
10-14 126 3 2.4 6 4.8 1 0.8 2 1.6 1 0.8
15-20 98 1 1.0 9 9.2 4 4.1 2 2.0 . .
Treatment Surgery only 1 . . . . . . . . . .
Chemotherapy, no radiation 95 . . 5 5.4 3 3.2 2 2.2 . .
Radiation, no chemotherapy 1 . . . . . . . . . .
Chemotherapy and radiation 224 3 1.3 14 6.3 4 1.8 4 1.8 2 0.9
Unknown 22 1 4.5 2 9.1 1 4.5 1 4.5 . .
CCSS data from Dec2010 and March 2015 data freeze 1 N and % based on response of 'Yes' 2 'Any hormonal problem' is based on a response of 'Yes' to one or more of the listed hormonal problems
Hormonal systems: Ewings 56
Diabetes- pills
(E.6/E.6) 1
Diabetes- insulin
(E.7/E.7) 1
Growth hormone deficiency (E.8/E.8) 1
Osteoporosis (E.10/E.10) 1
Any hormonal problem2
All cases N % N % N % N % N %
30-34 70 2 3.0 1 1.4 1 1.5 8 11.4 18 26.9
35+ 43 . . . . . . 4 9.3 10 23.3
Years since diagnosis 5-9 48 . . . . 2 4.3 3 6.3 6 12.8
10-14 126 1 0.8 . . 5 4.0 13 10.4 25 20.7
15-19 96 2 2.1 1 1.0 1 1.1 7 7.3 16 17.0
20+ 73 . . . . 2 2.7 11 15.1 23 31.9
Age at diagnosis <1 3 . . . . 1 33.3 1 33.3 1 33.3
1-4 25 . . . . 2 8.3 2 8.3 6 25.0
5-9 91 . . . . 3 3.3 11 12.1 18 20.2
10-14 126 1 0.8 1 0.8 4 3.2 10 7.9 24 19.5
15-20 98 2 2.1 . . . . 10 10.2 21 22.1
Treatment Surgery only 1 . . . . . . . . . .
Chemotherapy, no radiation 95 2 2.2 1 1.1 . . 5 5.3 12 13.2
Radiation, no chemotherapy 1 . . . . . . . . . .
Chemotherapy and radiation 224 1 0.5 . . 8 3.6 27 12.1 51 23.3
Unknown 22 . . . . 2 9.1 2 9.1 7 31.8
CCSS data from Dec2010 and March 2015 data freeze 1 N and % based on response of 'Yes' 2 'Any hormonal problem' is based on a response of 'Yes' to one or more of the listed hormonal problems
Hormonal systems: Osteosarcoma 57
Overactive thyroid
(E.1/E.1) 1
Underactive thyroid
(E.2/E.2) 1
Thyroid nodules (E.3/E.3) 1
Thyroid enlargement
(E.4/E.4) 1
Diabetes- diet (E.5/E.5)
1
All cases N % N % N % N % N %
Both sexes All cases 1205 12 1.0 33 2.8 16 1.3 23 1.9 15 1.2
Age at baseline <18 29 . . 1 3.4 . . . . . .
18-19 30 . . . . . . . . . .
20-24 198 1 0.5 5 2.5 2 1.0 3 1.5 1 0.5
25-29 333 2 0.6 10 3.0 4 1.2 7 2.1 2 0.6
30-34 356 5 1.4 10 2.8 6 1.7 7 2.0 7 2.0
35+ 259 4 1.6 7 2.7 4 1.5 6 2.3 5 1.9
Years since diagnosis 5-9 131 1 0.8 2 1.5 . . 1 0.8 . .
10-14 394 3 0.8 15 3.8 5 1.3 8 2.1 4 1.0
15-19 401 3 0.7 10 2.5 4 1.0 7 1.8 5 1.3
20+ 279 5 1.8 6 2.2 7 2.5 7 2.5 6 2.2
Age at diagnosis 1-4 24 1 4.3 1 4.3 1 4.3 . . . .
5-9 159 . . 3 1.9 1 0.6 2 1.3 . .
10-14 509 5 1.0 16 3.2 8 1.6 9 1.8 9 1.8
15-20 513 6 1.2 13 2.5 6 1.2 12 2.3 6 1.2
Treatment Surgery only 83 2 2.4 1 1.2 1 1.2 2 2.4 1 1.2
Chemotherapy, no radiation 907 10 1.1 28 3.1 14 1.6 19 2.1 13 1.4
Radiation, no chemotherapy 9 . . . . 1 11.1 1 11.1 . .
Chemotherapy and radiation 91 . . 1 1.1 . . . . . .
Unknown 115 . . 3 2.6 . . 1 0.9 1 0.9
Males All cases 624 6 1.0 7 1.1 6 1.0 7 1.1 3 0.5
Age at baseline <18 20 . . 1 5.0 . . . . . .
18-19 12 . . . . . . . . . .
20-24 95 . . 1 1.1 1 1.1 1 1.1 . .
25-29 180 2 1.1 3 1.7 2 1.1 2 1.1 . .
30-34 172 2 1.2 1 0.6 1 0.6 1 0.6 3 1.8
35+ 145 2 1.4 1 0.7 2 1.4 3 2.1 . .
Years since diagnosis 5-9 74 . . 1 1.4 . . . . . .
10-14 208 3 1.4 4 1.9 3 1.4 2 1.0 1 0.5
15-19 203 . . 2 1.0 . . 2 1.0 2 1.0
20+ 139 3 2.2 . . 3 2.2 3 2.2 . .
Age at diagnosis 1-4 13 1 7.7 1 7.7 1 7.7 . . . .
5-9 82 . . . . . . 1 1.2 . .
10-14 235 . . 3 1.3 1 0.4 2 0.9 . .
15-20 294 5 1.7 3 1.0 4 1.4 4 1.4 3 1.0
Treatment Surgery only 31 2 6.5 1 3.2 1 3.2 2 6.5 . .
Chemotherapy, no radiation 464 4 0.9 5 1.1 4 0.9 4 0.9 3 0.6
Radiation, no chemotherapy 5 . . . . 1 20.0 1 20.0 . .
Chemotherapy and radiation 50 . . . . . . . . . .
Unknown 74 . . 1 1.4 . . . . . .
Females All cases 581 6 1.0 26 4.5 10 1.7 16 2.8 12 2.1
Age at baseline <18 9 . . . . . . . . . .
18-19 18 . . . . . . . . . .
20-24 103 1 1.0 4 3.9 1 1.0 2 2.0 1 1.0
25-29 153 . . 7 4.6 2 1.3 5 3.3 2 1.3
30-34 184 3 1.6 9 4.9 5 2.7 6 3.3 4 2.2
CCSS data from Dec2010 and March 2015 data freeze 1 N and % based on response of 'Yes' 2 'Any hormonal problem' is based on a response of 'Yes' to one or more of the listed hormonal problems
Hormonal systems: Osteosarcoma 58
Diabetes- pills
(E.6/E.6) 1
Diabetes- insulin
(E.7/E.7) 1
Growth hormone deficiency (E.8/E.8) 1
Osteoporosis (E.10/E.10) 1
Any hormonal problem2
All cases N % N % N % N % N %
Both sexes All cases 1205 12 1.0 12 1.0 6 0.5 62 5.2 140 11.9
Age at baseline <18 29 . . 1 3.4 . . 2 6.9 4 13.8
18-19 30 . . . . . . . . . .
20-24 198 2 1.0 . . 2 1.0 14 7.1 22 11.5
25-29 333 1 0.3 2 0.6 2 0.6 15 4.6 34 10.6
30-34 356 5 1.4 6 1.7 1 0.3 20 5.7 48 13.9
35+ 259 4 1.5 3 1.2 1 0.4 11 4.2 32 12.5
Years since diagnosis 5-9 131 1 0.8 1 0.8 . . 6 4.6 9 7.3
10-14 394 3 0.8 2 0.5 2 0.5 20 5.1 46 11.9
15-19 401 5 1.3 5 1.2 3 0.8 20 5.0 46 11.7
20+ 279 3 1.1 4 1.4 1 0.4 16 5.8 39 14.3
Age at diagnosis 1-4 24 . . . . 1 4.3 1 4.3 3 13.0
5-9 159 . . 1 0.6 1 0.6 9 5.7 14 9.0
10-14 509 7 1.4 7 1.4 2 0.4 28 5.5 64 13.0
15-20 513 5 1.0 4 0.8 2 0.4 24 4.7 59 11.8
Treatment Surgery only 83 . . 3 3.6 . . 2 2.4 8 10.0
Chemotherapy, no radiation 907 12 1.3 8 0.9 4 0.4 53 5.9 118 13.4
Radiation, no chemotherapy 9 . . . . . . . . 1 11.1
Chemotherapy and radiation 91 . . 1 1.1 1 1.1 4 4.4 5 5.6
Unknown 115 . . . . 1 0.9 3 2.6 8 7.0
Males All cases 624 3 0.5 5 0.8 4 0.7 22 3.5 50 8.2
Age at baseline <18 20 . . 1 5.0 . . 1 5.0 3 15.0
18-19 12 . . . . . . . . . .
20-24 95 . . . . 1 1.1 4 4.2 7 7.8
25-29 180 . . . . 1 0.6 6 3.4 15 8.6
30-34 172 2 1.2 2 1.2 1 0.6 6 3.5 12 7.1
35+ 145 1 0.7 2 1.4 1 0.7 5 3.4 13 9.0
Years since diagnosis 5-9 74 . . 1 1.4 . . 2 2.7 4 5.9
10-14 208 . . . . 1 0.5 9 4.4 19 9.4
15-19 203 3 1.5 2 1.0 3 1.5 5 2.5 15 7.5
20+ 139 . . 2 1.4 . . 6 4.3 12 8.7
Age at diagnosis 1-4 13 . . . . . . . . 2 15.4
5-9 82 . . . . 1 1.2 3 3.7 5 6.3
10-14 235 1 0.4 3 1.3 1 0.4 8 3.4 15 6.6
15-20 294 2 0.7 2 0.7 2 0.7 11 3.8 28 9.8
Treatment Surgery only 31 . . 2 6.5 . . 2 6.5 7 22.6
Chemotherapy, no radiation 464 3 0.7 2 0.4 3 0.7 18 3.9 38 8.4
Radiation, no chemotherapy 5 . . . . . . . . 1 20.0
Chemotherapy and radiation 50 . . 1 2.0 . . . . 1 2.1
Unknown 74 . . . . 1 1.4 2 2.7 3 4.1
Females All cases 581 9 1.6 7 1.2 2 0.4 40 6.9 90 15.9
Age at baseline <18 9 . . . . . . 1 11.1 1 11.1
18-19 18 . . . . . . . . . .
20-24 103 2 2.0 . . 1 1.0 10 9.7 15 14.9
25-29 153 1 0.7 2 1.3 1 0.7 9 6.0 19 12.8
30-34 184 3 1.7 4 2.2 . . 14 7.7 36 20.3
CCSS data from Dec2010 and March 2015 data freeze 1 N and % based on response of 'Yes' 2 'Any hormonal problem' is based on a response of 'Yes' to one or more of the listed hormonal problems
Hormonal systems: Osteosarcoma 59
Overactive thyroid
(E.1/E.1) 1
Underactive thyroid
(E.2/E.2) 1
Thyroid nodules (E.3/E.3) 1
Thyroid enlargement
(E.4/E.4) 1
Diabetes- diet (E.5/E.5)
1
All cases N % N % N % N % N %
35+ 114 2 1.8 6 5.3 2 1.8 3 2.6 5 4.4
Years since diagnosis 5-9 57 1 1.8 1 1.8 . . 1 1.8 . .
10-14 186 . . 11 6.0 2 1.1 6 3.3 3 1.6
15-19 198 3 1.5 8 4.1 4 2.0 5 2.6 3 1.5
20+ 140 2 1.4 6 4.3 4 2.9 4 2.9 6 4.3
Age at diagnosis 1-4 11 . . . . . . . . . .
5-9 77 . . 3 3.9 1 1.3 1 1.3 . .
10-14 274 5 1.8 13 4.8 7 2.6 7 2.6 9 3.3
15-20 219 1 0.5 10 4.6 2 0.9 8 3.7 3 1.4
Treatment Surgery only 52 . . . . . . . . 1 1.9
Chemotherapy, no radiation 443 6 1.4 23 5.2 10 2.3 15 3.4 10 2.3
Radiation, no chemotherapy 4 . . . . . . . . . .
Chemotherapy and radiation 41 . . 1 2.4 . . . . . .
Unknown 41 . . 2 4.9 . . 1 2.4 1 2.4
CCSS data from Dec2010 and March 2015 data freeze 1 N and % based on response of 'Yes' 2 'Any hormonal problem' is based on a response of 'Yes' to one or more of the listed hormonal problems
Hormonal systems: Osteosarcoma 60
Diabetes- pills
(E.6/E.6) 1
Diabetes- insulin
(E.7/E.7) 1
Growth hormone deficiency (E.8/E.8) 1
Osteoporosis (E.10/E.10) 1
Any hormonal problem2
All cases N % N % N % N % N %
35+ 114 3 2.6 1 0.9 . . 6 5.3 19 17.0
Years since diagnosis 5-9 57 1 1.9 . . . . 4 7.0 5 9.1
10-14 186 3 1.6 2 1.1 1 0.5 11 5.9 27 14.8
15-19 198 2 1.0 3 1.5 . . 15 7.7 31 16.1
20+ 140 3 2.2 2 1.4 1 0.7 10 7.2 27 20.1
Age at diagnosis 1-4 11 . . . . 1 10.0 1 10.0 1 10.0
5-9 77 . . 1 1.3 . . 6 7.9 9 11.8
10-14 274 6 2.2 4 1.5 1 0.4 20 7.4 49 18.5
15-20 219 3 1.4 2 0.9 . . 13 6.0 31 14.5
Treatment Surgery only 52 . . 1 1.9 . . . . 1 2.0
Chemotherapy, no radiation 443 9 2.1 6 1.4 1 0.2 35 8.0 80 18.6
Radiation, no chemotherapy 4 . . . . . . . . . .
Chemotherapy and radiation 41 . . . . 1 2.4 4 9.8 4 9.8
Unknown 41 . . . . . . 1 2.4 5 12.2