holistic approach · 2020. 11. 22. · holistic approach to target skin ageing - 7th anti-ageing...

Holistic approach

to target skin ageing

Aïna QUEIROZ

Innovation & Scientif ic Communication

7 t h A n t i - A g e i n g S k i n C a r e C o n f e r e n c e

3 - 5 N o v e m b e r 2 0 2 0

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— Blockchain to guarantee tracability of cosmetic ingredients

The Evolutionary Biology of Beauty

Section 2 - Offer

Reproductive Strategy

Jokela, Markus. "Physical attractiveness and reproductive success in humans: evidence from the late 20th century United States." Evolution and Human Behavior 30.5 (2009): 342-350.

Section 2 Holistic approach to target skin ageing - 7th Anti-Ageing Skin Care Conference – Aïna Queiroz

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The Evolutionary Biology of Beauty

Section 2 - Offer

Section 2 Holistic approach to target skin ageing - 7th Anti-Ageing Skin Care Conference – Aïna Queiroz

Jokela, Markus. "Physical attractiveness and reproductive success in humans: evidence from the late 20th century United States." Evolution and Human Behavior 30.5 (2009): 342-350.

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The Human Beauty & the Brain

Section 2 - Offer 8

LONGEVITY AND HEALTHY AGING

Yarosh, Daniel B. "Perception and deception: Human beauty and the brain." Behavioral Sciences 9.4 (2019): 34.

Interpretation

Facial movement, emotion

Evaluation

Neurological rewards

STS

Identification

Facial images

OFC

STS

Deciding the value of attractiveness

Holistic approach to target skin ageing - 7th Anti-Ageing Skin Care Conference – Aïna Queiroz

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Don't get old: programmed failure


2. New inspirations: models of successful aging

Anti-ageing

A paradox leading to • Anxiety • Self-depreciation

Positive Aging

Holistic and multidimensionalwell-being, self-esteem andpositive emotional life

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Pro-aging: Research & Innovation strategies


Healthy aging

2. New scientific models: neuroscience & psychology

Self-perception

EMOSPINHolistic approach to target skin ageing - 7th Anti-Ageing Skin Care Conference – Aïna Queiroz

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Healthy aging


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— Blockchain to guarantee tracability of cosmetic ingredientsPChi, February 28th, 2019

“Longevity Hotspots”


Focus on Nutritional &Psychosocial aspects

Ikaria

Sardinia

Okinawa

Nicoya

Loma Linda


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Investigations into “Longevity Hotpots”


Local biodiversity study

Section 2 - Offer8LONGEVITY AND HEALTHY AGING

Scientific Surveys

Interview with Lilina, 99 years old

Gennargentu Mountains in central-southern Sardinia, April 2019


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Focusing on Okinawan Longevity


Ikaria

Sardinia

OkinawaNicoya

Loma Linda

Getto (Alpin ia spec iosa)

Quercetin-3-O-glucuronide, Quercetin-3-O-glucoside, Kaempférol-3-O-glucuronide, Kaempférol -3-O-glucoside


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Getto, a “life-expanding plant””

LONGEVITY AND HEALTHY AGINGHolistic approach to target skin ageing - 7th Anti-Ageing Skin Care Conference – Aïna Queiroz

Zingiberaceae, Alpinia genusEnglish common name: Shell ginger

Getto (Alpinia Zerumbet)syn. Alpinia speciosa

Getto extract significantly increase mean lifespan (by 22.6%)*

Treatment with getto extract (ALP) at 0, 25, 50, 100 µg/ml & resveratrol (RES) 100 µM.

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— Blockchain to guarantee tracability of cosmetic ingredients29th European dermocosmetology days, February 1st, 2019

*DEJ : dermal-epidermal junction

Pool of human dermal fibroblasts:

Passage 7 (normal human

dermal fibroblasts)

Passage 17 (aged human dermal

fibroblasts)

Hayfl ick cel lular senescence model

Cell-matrix interactions

Getto extract stimulates the

expression of key markers:

DEJ structuration

PChi, February 28th, 2019LONGEVITY AND HEALTHY AGINGHolistic approach to target skin ageing - 7th Anti-Ageing Skin Care Conference – Aïna Queiroz

Getto extract and skin ageing

1. In vitro model

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“Healthier aspect” of Skin and DEJ morphology

Untreated 2% of gettoextract

After 10 days of treatment with getto leaf extract:

Larger cells, with fulfilled and uniform cellular content

No spongiosis, early sign of cellular and tissue “suffering”

DEJ undulation is enhanced


Living explants from

abdominoplasty coming from

Caucasian woman.

Topical application (D0, D2,

D3, D6 & D8)

Laminin-5 immunostaining

2. Ex vivo Model

Getto extract and skin ageing

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Living explants from

abdominoplasty coming from

Caucasian woman.

Topical application (D0, D2,

D3, D6 & D8)

Laminin-5 immunostaining

After 10 days of treatment with getto leaf extract:

Laminin 5 synthesis is significantly boosted

** p

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Skin texture & Glow

3Section 1 - Strategic territories and know how

3. Clinical Model

Skin texture is smoothed

Skin glow is enhanced

Hemi-face application

• 25 woman with urban life

• 40-60 years old

• Double-blind study

• Evaluation at T0, T28, T56 days:

Skin texture

Skin glow

placebo 2% gettoextract


After 28 days of topical application:

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Healthy aging


Self-perception


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Exopolysaccharides: underwater symbiosis

Emotional Beauty : Towards a more holistic view of age and self-perception Arnaud Aubert - Aïna QUEIROZ

The symbiosis between sea anemone & clownfish is not exclusive…

Example of symbiosis: translocation of nitrogen from bacteria to sea anemone 2

Hosting of bacteria: co-evolution and mutualistic relationship1

1Blackall et al. (2015)2Li Zhiyong et al. (2009)


EPS Glycuron 2.78

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3D sugar deciphering & biological predictions Biometric and emotional

parameter measurements

GLYcoPROFILING

Mirror-test

In vitro study

Clinical study

Deciphering giant exopolysaccharides

EPS Glycuron 2.78


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From biometric parameters to the emotional state


Exceptional Longevity & Perception of Beauty - SFC SYMPOSIUM - December 4th, 2019 – Aïna Queiroz

Clinical Model

Quantification of emotional load in voice modulations

• Loudness (dB)• Pitch (tone): (Hz)

Two groups

• 45 Healthy caucasian

• 45-60 years old


• Two measure points:

T0, T28

B1% active

APlacebo

1. Biometrics measurements

Analysis of spontaneous lexical field

• Self-perception• Allo-perception

Verbatim

• Luminosity• Skin texture

2. Emotional assessment

Vocal prosody


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Biometrical & Emotional assessments



2. Clinical Model

Skin luminosity & texture are enhanced

1. Biometrics measurements

Two groups


• 45-60 years old



T0, T28

B1% active

APlacebo


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2. Clinical Model

Quantification of emotional load in voice modulations

• Loudness (dB)• Pitch (tone): (Hz)

Vocal prosody

Two groups


• 45-60 years old



T0, T28

B1% active

APlacebo


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2. Clinical ModelVeratim

Group A (Placebo)

– Sociable (t=3,0; p=0,0012)

– Looking tired (t=2,4; p=0,0074)

– Wrinkly (t=2,2; p=0,0355)

– Simple (t=1,8; p=0,0355)

– Average (t=1,6; p=0,0556)

Group B (1% of active)

– Joyful (t=2,5; p=0,0071)

– Fun (t=2,0; p=0,0238)

– Feel good about myself (t=2,0;p=0,0238)

– Less red spots (t=1,8; p=0,0371)

– Smiling (t=1,7; p=00485)

– Look tired (t=1,5; p=0,0630)

Statistically significant terms used by:

Verbatim2. Emotional assessment

Two groups


• 45-60 years old



T0, T28

B1% active

APlacebo


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From the perception of change to self-esteem enhancement

Active ingredient

Skin properties

Self-perception: brain selection of specific visual cuesAmplification of changes in relevant visual cues

Positive emotional response

Self-esteem and well-being

+

+++

Section 2 - Offer 8

LONGEVITY AND HEALTHY AGINGExceptional Longevity & Perception of Beauty - SFC SYMPOSIUM - December 4th, 2019 – Aïna Queiroz

EPS Glycuron 2.78


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Conclusion


Healthy aging


Self-perception


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Aging is the new black ?

Section 2 - Offer 8

LONGEVITY AND HEALTHY AGINGExceptional Longevity & Perception of Beauty - SFC SYMPOSIUM - December 4th, 2019 – Aïna QueirozHolistic approach to target skin ageing - 7th Anti-Ageing Skin Care Conference – Aïna Queiroz

Thanks

For your attention

Aïna QUEIROZ

Innovation & Scientif ic Communication

7 t h A n t i - A g e i n g S k i n C a r e C o n f e r e n c e

3 - 5 N o v e m b e r 2 0 2 0

holistic approach · 2020. 11. 22. · holistic approach to target skin ageing - 7th anti-ageing...

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