HMP Shunt

Oxidative phase

STEP 1

STEP 2

STEP 3

STEP 4

Non-oxidative phase

STEP 1

STEP 2

STEP 3

Summary of phase 2

Regulation

gggGLU6PO4 is shunted between

glycolysis and HMP Shunt

• Glycolysis , gluconeogenesis and HMP shunt are inter -related

Physiological significance

• 1)NADPH

• 2)Pentose sugar ribose

Physiological significance

Free radical scavenging

Maintenance of RBC membrane integrity NADPH CONCENTRATION

5mM

Sorbitol pathway

Respiratory burst

Clinical significance

• 1)G6PD deficiency and favism

• Normal concentration of G6PD IS

• 6 – 12 U/ gm Hb

• 2)MethHb

• 3)Wernickes korsakoff syndrome