CROI 2012

Hansjakob Furrer

Clinical aspectsAntiretroviral Drugs

Amy JusticeAging with HIV or Premature Aging

Accentuated

Acceleratedand

Accentuated

Ann Intern Med. 2010;153:452-460.

CVD Risk: Are Patients with HIV any Different? (Stein)

Independent Biomarkers of CHDin the cardiology world

Anal Intraepithelial Neoplasia in HIV+ MSM, Randomized Trial of TTT

N=148 Imiquimod 5-Fluoruracil ElectrocauteryResponse 39% 29% 48%

CompleteResponse

26% 17% 41%

Recurrence 25% 57% 17%

Severe AE 43% 27% 18%

LEDGIN: Inhibitoren der LEDGF –Integrase Interaktion (Christ)

• LEDGF/p75 verbindet die Integrase mit dem Chromatin und ermöglicht damit die Integration

• Allosterische Inhibitoren dieser Interaktion werden präklinisch evaluiert

Cell. Mol. Life Sci. Vol. 65, 2008

Kombination LEDGIN und INI

QUAD vs Atripla: non-inferior (Sax)

Kreatininanstieg: tubuläre Kreatininsekretion gehemmt

Nebenwirkungen

Dolutegravir 2B (SPRING) Stellbrink

Impact of switching from AZT/3TC to TDF/FTC on bone mineral density and

bone metabolism in virologicallysuppressed HIV-1 infected patients

The PREPARE Bone Biomarker Sub-Study

Aoife G. Cotter

% Change in BMD (Week 48–baseline)

Randomisation groupContinue AZT/3TC Switch to TDF/FTC

BMDMedian (IQR)

Within Group

P-value

Median (IQR)

Within GroupP-value

Between GroupP-value

Femoral Neck 0.14 (-3.26, 1.63) 0.74 -1.52 (-3.04, 0.22) 0.16 0.48

Lumbar Spine -0.18 (-2.35, 1.85) 0.91 -2.04 (-3.28, -0.40) 0.01 0.03

Associations between change in bone biomarkers and change in lumbar spine BMD

CTX-1 OC P1NP

Change in CTX-1 Effect 95% C.I. P-valueSwitch to TDF/FTC 8.2 5.3, 11.2 <0.0001Baseline CTX-1 (µg/L) -17.1 -26.0, -8.1 0.0005Male gender 2.2 -2.0, 6.4 0.31Caucasian ethnicity 0.45 -2.78, 3.68 0.79

Change in OC Effect 95% C.I. P-valueSwitch to TDF/FTC 297.1 209.5, 384.7 <0.0001Baseline OC (µg/L) -4.7 -11.2, 1.8 0.16Male gender -26.4 -154.2, 101.5 0.69Caucasian ethnicity -43.8 -142.3, 54.7 0.39

Change in P1NP Effect 95% C.I. P-valueTDF/FTC 841.4 564.8, 1132.8 <0.0001Baseline P1NP (µg/L) -2.9 -11.7, 6.4 0.55Male gender -145.4 -154.2, 101.5 0.48Caucasian ethnicity -18.4 -142.3, 54.7 0.91

Results of multivariable linear regression models for predictors of change in CTX-1, OC & P1NP

GS-7340; neue Tenofovir ProdrugRuane

10 Tages virologisches Ansprechen

CD4 bei ART Start 2009 (Egger)