histology of kidney and urinary system

7/28/2019 Histology of Kidney and Urinary System

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Dr. Maolin


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Urinary tract

Urinary tract 2 kidneys

2 ureter

1 urinary bladder

1 urethra

Kidney function Acid base balance

Excrete waste product

Maintain volume extracelluler fluid Endocrine function

Eritropoietin

renin


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Kidney

Retroperitoneal

Length 10-12cm, width 5-6cm, AP 3-4cm

Medial border : hillum

Renal sinus Renal pelvis

Nephrons (1,5-3 million) Renal corpuscle

Proximal convoluted tubule (PCT) Loop of henle

Distal convoluted tubule (DCT)


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Kidney

Uriniferous tubule Nephrons

Collecting tubule

Collecting duct

Corteks

Renal corpuscle PCT and DCT

Collecting tubule

Medulla Loopof henle

Collecting duct

Filtrate nephron composition (+ metabolic waste &selective reabsorb) collecting segment absorb water concentrate urine to papillary duct (duct of bellini)


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Nephron

Renal corpuscle

Prox. Convoluted Tubule (PCT)

Loop of Henle

Distal Convoluted Tubule (DCT)

Collecting segment


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Nephron::renal corpuscle

Bowman capsule : cup shape,

expansion of PCT

Visceral layer (podocyte)

Parietal layer

Glomerulus

Vascular pole

Urinary pole

Podocyte


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Podocytes Pedicles (foot processes)

Slit diafragma, consist of neprin space,fx:filtration slit for water, glucose, as, amino,metabolic waste produt, no protein plasma

Basal lamina Lamina rara eksterna

Intermediate lamina densa

Lamina rara interna

Sel mesangial : space between glomerularcapillary, fx: fagosit, basal lamina turnover


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Nephron::PCT

Cuboidal/lowcolumnar cell

Brush border

Apical canaliculi endocytosis

macromolecule

Absorb 85% water and salt, glucose,

as.amino, excrete creatinine


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Nephron::loop of Henle

Descending thick limb

Descending thin limb, fx: pump NA and Cl,

reabsorb 5% of water

Junction between desc thick limb n thin limb

Brush border ends n cuboidal epithelium

squamous epithelium, few microvilli.


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Nephron::DCT

Cuboidal cell, short microvilli, no brush

border, no apical canaliculi

Specialized darker staining cell

macula densa

Fx: controlled by ADH absorb Na,

secretes K, absorb 8% of water


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Nephron::collecting segment

Principal cell (short microvilli)

Intercalated cell, fx: acid base balance

by reabsorb bicarbonate

Controlled by ADH, absorb 4% of water


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Juxtaglomerular complex

1. Specialized cell of macula densa DCT

2. JGC modifying smooth muscle cell of

afferent arteriola

3. Mesangial cell

Produce secretory granule renin


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Blood supply

Renal artery lobar artery interlobar

artery arcuate artery interlobular

artery intralobular artery afferent

arteriol efferent artriol vasa recta Vena : stellate vein interlobular vein

arcuate vein interlobar vein

renal vein


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Renal pelvis and ureter

Trantitional epithel

Muscle contraction : peristaltic waves


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Urinary bladder

Mucosa : transtitional epithel

Muscle layer

Outer : longitudinal

Medial : circular/oblique

Inner : longitudinal


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Urethra

Above ejaculatory duct : transtitional

epithel

Distal ejaculatory duct : pseudostratified

columnar

Penile : stratified squamous epithel

Women : stratified squamous epithel

histology of kidney and urinary system

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