Histology LaboratoriesMolecules to Systems

2003Compiled by

James D. Jamieson, MD/PhDThomas L. Lentz, MD

No part of this image collection may be distributed outside of the Yale University Intranet.

Alberts, B. et al. Molecular Biology of the Cell. 4th Edition, Garland Science, New York, 2002.Gartner, L. P. and Hiatt, J. L. Color Atlas of Histology, Williams & Wilkins,

Baltimore, 1994.Kerr, J. B. Atlas of Functional Histology. Mosby, London, 1999.Kessel, R. G. and Kardon, R. H. Tissues and Organs: a text-atlas of scanning

electron microscopy. W. H. Freeman, San Francisco, 1979.Lentz, T. L. Cell Fine Structure. W. B. Saunders, Philadelphia, 1971.Lodish, H. et al. Molecular Cell Biology. W. H. Freeman, New York, 2000.Mizoguti, H. Color Slide Atlas of Histology. Nihon Shashin Shinbunsha, Tokyo.Young, B. and Heath, J. W. Wheater’s Functional Histology. Churchill

Livingstone, Edinburgh, 2000.Micrographs taken by George Palade, Marilyn Farquhar, James D. Jamieson,

Nicolai Simionescu, Maya Simionescu, David Castle, Thomas L. Lentz.

Web Resourceshttp://info.med.yale.edu/webpath/webpath.htmCushing Library Educational Software/Cell Biology/Several Histology Resources

AcknowledgementsSources of Micrographs, Diagrams and Figures

Lymphoid System Laboratory

Plasma Cell

Peyer’s Patches (Lymphoid Follicles) in Small Gut

Germinal Center (GC)

Organized GALT/MALT

Diffuse GALT in gut lamina propria

GALT: gut-associated lymphoid tissueMALT: mucosa-associated lymphoid tissue

Peyer’s Patch

Lymphoid follicleGerminal center

Lymph Node

Cortex

Medulla

Secondary follicles

Subcapsular sinus

Efferent lymphatics

Hilus Medullary cords

Afferent lymphatic

Medulla

Cortex

Germinal centers

Lymph Node

Subcapsular sinus

Afferent lymphatic with valve (V)

Secondary Follicle

Germinal center: B cell proliferation and maturation

Mantle of resting and memory B cells

Reticulin stain of lymph node

Palatine tonsil

Thymus

Cortex

Medulla

Thymus

Cortex (developing T cells)

Medulla

Thymic medulla with Hassall’s corpuscles

Hassall’s corpuscles

Development of T cells in Thymus

Spleen

Spleen

Red pulp

White pulp

PALS

Trabeular artery

B cell mantle

PALS (T cells)

GC

Central arteriole

Spleen

Spleen Red Pulp

Endothelial cells

Venous sinus

Direction of blood flow in spleen

Organization of the spleen

Some Pathology

Benign Reactive Lymph Node

Benign Reactive Lymph NodeWhich cells are responding?

Adenocarcinoma Metastases to Lymph NodeHow did the tumor cells get to this location?

Adenocarcinoma Metastases to Lymph NodeHow did the tumor cells get to this location?