histology laboratories molecules to systems 2003 compiled by james d. jamieson, md/phd
DESCRIPTION
Histology Laboratories Molecules to Systems 2003 Compiled by James D. Jamieson, MD/PhD Thomas L. Lentz, MD. No part of this image collection may be distributed outside of the Yale University Intranet. Acknowledgements. Sources of Micrographs, Diagrams and Figures. - PowerPoint PPT PresentationTRANSCRIPT
Histology LaboratoriesMolecules to Systems
2003Compiled by
James D. Jamieson, MD/PhDThomas L. Lentz, MD
No part of this image collection may be distributed outside of the Yale University Intranet.
Alberts, B. et al. Molecular Biology of the Cell. 4th Edition, Garland Science, New York, 2002.Gartner, L. P. and Hiatt, J. L. Color Atlas of Histology, Williams & Wilkins,
Baltimore, 1994.Kerr, J. B. Atlas of Functional Histology. Mosby, London, 1999.Kessel, R. G. and Kardon, R. H. Tissues and Organs: a text-atlas of scanning
electron microscopy. W. H. Freeman, San Francisco, 1979.Lentz, T. L. Cell Fine Structure. W. B. Saunders, Philadelphia, 1971.Lodish, H. et al. Molecular Cell Biology. W. H. Freeman, New York, 2000.Mizoguti, H. Color Slide Atlas of Histology. Nihon Shashin Shinbunsha, Tokyo.Young, B. and Heath, J. W. Wheater’s Functional Histology. Churchill
Livingstone, Edinburgh, 2000.Micrographs taken by George Palade, Marilyn Farquhar, James D. Jamieson,
Nicolai Simionescu, Maya Simionescu, David Castle, Thomas L. Lentz.
Web Resourceshttp://info.med.yale.edu/webpath/webpath.htmCushing Library Educational Software/Cell Biology/Several Histology Resources
AcknowledgementsSources of Micrographs, Diagrams and Figures
Lymphoid System Laboratory
Plasma Cell
Peyer’s Patches (Lymphoid Follicles) in Small Gut
Germinal Center (GC)
Organized GALT/MALT
Diffuse GALT in gut lamina propria
GALT: gut-associated lymphoid tissueMALT: mucosa-associated lymphoid tissue
Peyer’s Patch
Lymphoid follicleGerminal center
Lymph Node
Cortex
Medulla
Secondary follicles
Subcapsular sinus
Efferent lymphatics
Hilus Medullary cords
Afferent lymphatic
Medulla
Cortex
Germinal centers
Lymph Node
Subcapsular sinus
Afferent lymphatic with valve (V)
Secondary Follicle
Germinal center: B cell proliferation and maturation
Mantle of resting and memory B cells
Reticulin stain of lymph node
Palatine tonsil
Thymus
Cortex
Medulla
Thymus
Cortex (developing T cells)
Medulla
Thymic medulla with Hassall’s corpuscles
Hassall’s corpuscles
Development of T cells in Thymus
Spleen
Spleen
Red pulp
White pulp
PALS
Trabeular artery
B cell mantle
PALS (T cells)
GC
Central arteriole
Spleen
Spleen Red Pulp
Endothelial cells
Venous sinus
Direction of blood flow in spleen
Organization of the spleen
Some Pathology
Benign Reactive Lymph Node
Benign Reactive Lymph NodeWhich cells are responding?
Adenocarcinoma Metastases to Lymph NodeHow did the tumor cells get to this location?
Adenocarcinoma Metastases to Lymph NodeHow did the tumor cells get to this location?