histo on your nerves
DESCRIPTION
Histo On Your Nerves. SSN Histology October 26th, 2004 Missy Walker, [email protected] So Young Kim, [email protected]. So what’s in a nerve?. Dendrite. Axon Terminal. Perikaryon. Nucleus of myelin-producing cells. Node of Ranvier. Axon. Myelin-Producing Cell. Axon Hillock. - PowerPoint PPT PresentationTRANSCRIPT
Histo On Histo On Your NervesYour Nerves
SSN HistologySSN Histology
October 26th, 2004October 26th, 2004
Missy Walker, [email protected] Walker, [email protected]
So Young Kim, [email protected] Young Kim, [email protected]
Node of Ranvier
Perikaryon
Myelin-Producing Cell
So what’s in a nerve? So what’s in a nerve?
Axon Hillock
Dendrite
Axon Terminal
Axon
Nucleus of myelin-producing cells
Axon vs. DendriteAxon vs. Dendrite
Axon DendriteNONO Synthetic Synthetic Machinery! Machinery!
Nervous System ClassificationsNervous System Classifications
Nervous System
CNS PNS
Spinal Cord Cerebellum Cerebral Cx ANS Somatic Enteric (Ganglia) (Peripheral Nerve)
Spinal CordSpinal Cord
Spinal Cord: White MatterSpinal Cord: White Matter
Myelin Production in CNSMyelin Production in CNS
Oligodendrocytes
Spinal Cord Gray MatterSpinal Cord Gray Matter
Spinal CordSpinal Cord
Cajal’s Silver
MeningesMeninges
AstrocytesAstrocytes
No collagen in the CNS!!! No collagen in the CNS!!!
BrainBrain
CerebellumCerebellum
CerebellumCerebellum
Purkinje CellPurkinje Cell
Cerebral CortexCerebral Cortex
Cerebral CortexCerebral Cortex
Cerebellum vs. Cerebral CxCerebellum vs. Cerebral Cx
Cerebellum vs. Cerebral CortexCerebellum vs. Cerebral Cortex
Pyramidal Cells vs. Spinal Cord Gray Pyramidal Cells vs. Spinal Cord Gray MatterMatter
Peripheral Nervous System (PNS)Peripheral Nervous System (PNS) Nervous tissue outside of the brain and spinal cordNervous tissue outside of the brain and spinal cord
Somatic Nervous System
• Innervates skeletal muscle
• For conscious movement
• Cell bodies in CNS
Autonomic Nervous System
• Innervates smooth muscle and glands
• For organ function and regulation
• Cell bodies in CNS and PNS
Sympathetic & Parasympathetic
ANS - GangliaANS - Ganglia
Sympathetic GANGLIA in thorax contain:
• neuronal cell bodies
• satellite cells (support cells of the neuron)
Synapses occur
• Presynaptic fibers myelinated
• Postsynaptic fibers unmyelinated
Enteric NS - GangliaEnteric NS - Ganglia
Myenteric plexus in ENS
• Within Smooth Muscle of Gut
• NO Collagen (as in CNS)
• Glial cells (no Schwann cells)
• Nuclei are euchromatic
• Gut has “mind of its own”
ENS Ganglion vs ANS Ganglion ENS Ganglion vs ANS Ganglion
Cross section of nerveCross section of nerve
Organization by
Connective Tissues
• Endoneurium collagen fibers associated with individual neurons -Schwann cells within
• Perineurium layer(s) of connective tissue cells, create fascicles
• Epineurium dense cnxtive tissue binding fascicles into a bundle
Peripheral nervePeripheral nerve
• Epineurium
• Perineurium
• Endoneurium
Periph nerve Periph nerve - longitudinal section- longitudinal section
• Endoneurium• Perineurium• Epineurium
Longitudinal Section – Cajal stainLongitudinal Section – Cajal stain
Peripheral Nerve – High Power (Cajal)Peripheral Nerve – High Power (Cajal)
• Nodes of Ranvier• Neurilemma
(cytoplasm of Schwann cells)
• What’s the black?
Peripheral Nerve – High Power (H&E)Peripheral Nerve – High Power (H&E)
What’s the purple? What’s the white?
Cross Section – Peripheral NerveCross Section – Peripheral Nerve
• What’s the purple?
Peripheral NervePeripheral Nerve
• Why is this a Nerve, not a Ganglion?
Key Points for PNSKey Points for PNS• Ganglia
– Contain cell bodies for motor ANS
– Satellite cells are the supporting cell bodies (not glial, Schwann, or others of CNS)
• Peripheral Nerves
– Schwann cells make mylin sheath
– Node of Ranvier / saltatory conduction / Na channels
– Endoneurium around neurons, which form fascicles
– Perineurium around fascicles, which form bundles
– Epineurium around bundles
Same or different?Same or different?
Same or different?Same or different?
What are these?What are these?
Questions 1 & 2. . .
A
B
Question 3. . . Question 3. . .
Figure A Figure B
Question 4. . . Question 4. . .
Question 5. . . Question 5. . .
Question 6. . . Question 6. . .