hepático 1
TRANSCRIPT
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Patologia Especial Veterinária2010 – 1AULA 01
Profa. Josiane Bonel-Raposo
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Anatomia e Histologia Insuficiência Hepática Padrões de Lesão
Hepática Hepatopatias Neoplasias
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Cápsula de Glisson Parênquima:
Lâminas de hepatócitos Sinusóides Áreas portais:
veia porta, artéria hepática, vasos linfáticos, ductos biliares e nervos
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Veia porta: sangue venoso com nutrientes
Artéria hepática: sangue arterial com oxigênio
Misturam-se nos sinusóides
Fluxo biliar é o oposto ao do sangue
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Metabolismo da bilirrubina
Metabolismo dos ácidos graxos
Metabolismo de carboidratos e
lipídios
Metabolismo de xenobióticos
Síntese protéica
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EtiopatogenEtiopatogeniaia
Metabolismo normal das gorduras
TGColestero lFosfo lip íd ios
TG
Acetil-COACetonas
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1) Aporte excessivo de ácidos graxos
para o fígado
2) Diminuição no volume de oxidação
dos ácidos graxos
3) Síntese excessiva de triglicerídeos
4) Falha na formação da lipoproteína
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Aporte excessivo de ácidos graxos Aporte excessivo de ácidos graxos para o fígadopara o fígado
TGColestero lFosfo lip íd ios
TG
Acetil-COACetonas
Dieta rica em gorduras Cetose
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Diminuição no volume de oxidação Diminuição no volume de oxidação dos ácidos graxosdos ácidos graxos
TGAnemiaHipóxiaTóxicos
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Síntese excessiva de triglicérides Síntese excessiva de triglicérides no RERno RER
Álcool
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Falha na formação da lipoproteínaFalha na formação da lipoproteína
Déficit protéico na dieta
Falha na liberação de proteínas no hepatócito
Distúrbio na síntese protéica
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Fígado normal
Degeneraçãogordurosa
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H-E
Sudan IV
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CetoseCetose
Doença metabólica que resulta da mobilização de CH e AGV prejudicados.
Ocorre quando o metabolismo das gorduras se torna excessivo devido ao aumento nas necessidades de energia.
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Final da gestação
Partos gemelares
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Vacas prenhes ou em lactação Demanda contínua por glicose e aminoácidos Pico da lactação
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Anatomia e Histologia
Padrões de lesão
Hepática
Insuficiência hepática
Hepatopatias
Neoplasias
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NecroseNecrose
Normal
Normal
Agressão tóxica aguda
Sem agressão adicional
Agressão repetida
Agressão repetida
Fibrose Fibrose inicialinicial
Fibrose progressiv
a
CirroseCirrose
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Necrose
Regeneração
Fibrose
Cirrose
Hiperplasia de Ductos Biliares
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InflamaçõesInflamaçõesFígado
Hepatite aguda Hepatite crônica
Trato biliar Colangite
Colangio-hepatiteColangio-hepatite
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Individual
Periportal
Mediozonal
Centrolobular
Massiva ou maciça (Hepatose
dietética)
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Regeneração
Fibrose (Cirrose)
Hiperplasia biliar
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Regeneração
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Regeneração
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Regeneração
Fibrose (Cirrose)
Hiperplasia biliar
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Fibrose
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Fibrose
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Regeneração
Fibrose (Cirrose)
Hiperplasia biliar
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Hiperplasia biliar
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Anatomia e Histologia
Padrões de lesão Hepática
Insuficiência hepática
Hepatopatias
Neoplasmas
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Icterícia
Fotossensibilização
Distúrbios Metabólicos Tendências hemorrágicas Hipoalbuminemia e edemas
Encefalopatia Hepática
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Conceito
Alterações Extra-hepáticas
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Icterícia
Fotossensibilização
Doenças
hemorrágicas
Encefalopatia
hepática
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Intoxicação crônica por cobre
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LeptospirosLeptospiroseeIcterícia pré-
hepática
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Icterícia
Fotossensibilização
Distúrbios metabólicos
Encefalopatia hepática
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Fotossensibilização PrimáriaFotossensibilização Primária
Substância fotodinâmica exógena
Fotossensibilização Fotossensibilização
HepatógenaHepatógena
Lesão no fígado
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Subst. Subst. fotodinâmicafotodinâmica
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Ammi majusAmmi majus
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Ammi majus
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Rúmen
Fígado
ClorofilaClorofila
ClorofilaClorofila
FiloeritrinaFiloeritrina
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Brachiaria sp.
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Brachiaria sp.
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Brachiaria sp.
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Brachiaria sp.
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Brachiaria sp.
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Brachiaria sp.
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Myoporum laetum
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Myoporum laetum
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Myoporum laetum
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Myoporum laetum
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Icterícia
Fotossensibilização
Distúrbios metabólicos
Encefalopatia hepática
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Diátese hemorrágica
Deficiência dos fatores de coagulação
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Icterícia
Fotossensibilização
Doenças hemorrágicas
Encefalopatia hepática
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Coma hepático, encefalopatia portossistêmica
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