hd introducing xenium xph - baxter · latest innovation in baxter’s hd product portfolio builds...

hd

Xenium XPHIntroducing Xenium XPHHigh-Flux Synthetic Dialyzers

Xenium XPH Dialyzers

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� Latest innovation in Baxter’s HD product portfolio� Builds on success of Xenium dialyzer to deliver exceptional

performance


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� Available in six surface area sizes� Incorporates Polynephron synthetic membrane

Polynephron membrane

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� Next-generation polyethersulfone (PES) offers� Improved middle molecule clearances1

� Excellent urea clearances1

� Biocompatibility

1. Manufacturers’ published data sheets (Baxter Xenium XPH series, Gambro Polyflux H series and Revaclear series dialyzers, and Fresenius Optiflux series dialyzers)

Competitive Comparisons

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� Urea and Vitamin B12 clearance comparisons� Xenium XPH Dialyzer� Polyflux� Optiflux� Revaclear

Xenium XPH vs. competition

Sm

all M

olec

ule

Cle

aran

ce (

Ure

a, m

L/m

in)

HIGH-FLUX DIALYZER IN-VITRO CLEARANCE COMPARISONS (QB 300 mL/min Q D 500 mL/min)Optiflux, Polyflux and Revaclear data adjusted to 10 mL/min Ultrafiltration Rate Qf†

275—

280—

285—

290—

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245—|

140

Sm

all M

olec

ule

Cle

aran

ce (

Ure

a, m

L/m

in)

Middle Molecule Clearance (Vitamin B 12, mL/min)

� Improved middle molecule clearance

� Excellent urea clearance

� Advanced synthetic membrane

Best-in-class features:

250—

255—

260—

265—

270—

275—

|150

|160

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|180

|190

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†Adjustment performed per Table A-3: Equations for dialyzer KoA from In vitro clearances. In Handbook of Dialysis, 4th ed, Daugirdas JT, Blake PB, Ing TS (Eds), Lippincott Williams and Wilkins, Philadelphia, 2007, p. 729.

Xenium XPH vs. OptifluxS

mal

l Mol

ecul

e C

lear

ance

(U

rea,

mL/

min

)

275—

280—

285—

290—

HIGH-FLUX DIALYZER IN-VITRO CLEARANCE COMPARISONS (QB 300 mL/min Q D 500 mL/min)Optiflux data adjusted to 10 mL/min Ultrafiltration Rate Qf†

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245—|

140

Sm

all M

olec

ule

Cle

aran

ce (

Ure

a, m

L/m

in)



250—

255—

260—

265—

270—

275—

|150

|160

|170

|180

|190

|200

|210

|220





Xenium XPH vs. PolyfluxS

mal

l Mol

ecul

e C

lear

ance

(U

rea,

mL/

min

)

275—

280—

285—

290—

HIGH-FLUX DIALYZER IN-VITRO CLEARANCE COMPARISONS (QB 300 mL/min Q D 500 mL/min)Polyflux data adjusted to 10 mL/min Ultrafiltration Rate Qf†

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245—|

140

Sm

all M

olec

ule

Cle

aran

ce (

Ure

a, m

L/m

in)



250—

255—

260—

265—

270—

275—

|150

|160

|170

|180

|190

|200

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Does size matter?

� The Polynephron membrane allows the Xenium XPH dialyzer to achieve better clearance rates with similar or smaller surface areas

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Does size matter?S

mal

l Mol

ecul

e C

lear

ance

(U

rea,

mL/

min

)

275—

280—

285—

290—

HIGH-FLUX DIALYZER IN-VITRO CLEARANCE COMPARISONS (QB 300 mL/min Q D 500 mL/min)Optiflux and Polyflux data adjusted to 10 mL/min Ultrafiltration Rate Qf†

10

245—|

140

Sm

all M

olec

ule

Cle

aran

ce (

Ure

a, m

L/m

in)



250—

255—

260—

265—

270—

275—

|150

|160

|170

|180

|190

|200

|210

|220





Xenium XPH vs. RevaclearS

mal

l Mol

ecul

e C

lear

ance

(U

rea,

mL/

min

)

275—

280—

285—

290—

HIGH-FLUX DIALYZER IN-VITRO CLEARANCE COMPARISONS (QB 300 mL/min Q D 500 mL/min)Revaclear data adjusted to 10 mL/min Ultrafiltration Rate Qf†

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245—|

140

Sm

all M

olec

ule

Cle

aran

ce (

Ure

a, m

L/m

in)



250—

255—

260—

265—

270—

275—

|150

|160

|170

|180

|190

|200

|210

|220





Xenium XPH performance factors

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� Polynephron fiber� Designed with micro-undulations built into fibers2

� Delivers optimal flow dynamics to avoid dialysate channeling� Provides for ideal dialysate distribution

2. Data on file


�Polynephron membrane (magnified)

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� Xenium XPH fibers’ optimized structure3

� Provides uniform pore distribution and wall thickness

�Polynephron membrane (magnified)

3. Data on file

Endotoxin adsorption

� A recent study titled “Cytokine-Inducing-Substances with New High Flux Membranes”4 conducted by Pokropinski, S., et al, concluded that Xenium XPH’s Polynephron fibers:� Exhibit remarkable capacity to adsorb endotoxins

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� Exhibit remarkable capacity to adsorb endotoxins� May be impermeable to endotoxins

4. Pokropinski S, Supina C, Gewalt P, et al. Cytokine-Inducing-Substances with New High Flux Membranes. Abstract. Hemodialysis International 13, no. 1, (2009): 98-99


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� Casing technology� Designed with slim-line chamber

� Allows for tight fiber pack-factor� Facilitates optimized dialysate flow

Xenium XPH safety features

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� Safety features� Unique, oxygen-free gamma sterilization process helps reduce risk

from free radical formation during sterilization

Xenium XPH safety features

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� Safety features� Added caps on dialysate ports� Easily identifiable blood inlet and outlet colors� Easy-to-distinguish color-coded labels, by size


Warning: This product is intended for single use on ly.

Caution: Federal (US) law restricts these devices to sale by

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Caution: Federal (US) law restricts these devices to sale by or on the order of a physician or other licensed practitioner.

For safe and proper use of these devices refer to the device instructions.


References:1. Manufacturers’ published data sheets (Baxter Xenium XPH series, Gambro Polyflux H series and

Revaclear series dialyzers, and Fresenius Optiflux series dialyzers)2. Data on file3. Data on file4. Pokropinski S, Supina C, Gewalt P, et al. Cytokine-Inducing-Substances with New High Flux

Membranes. Abstract. Hemodialysis International 13, no. 1, (2009): 98-99

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Membranes. Abstract. Hemodialysis International 13, no. 1, (2009): 98-99

Baxter and Xenium are trademarks of Baxter International Inc. Polynephron is a trademark of Nipro Corporation. Optiflux is a trademark of Fresenius Medical Care. Polyflux and Revaclear are trademarks of Gambro AB Corporation.

AL09299 10/09

hd introducing xenium xph - baxter · latest innovation in baxter’s hd product portfolio builds...

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