hba 09 presentation
DESCRIPTION
This is a presentation on the process of formulating customized cosmeceuticals.TRANSCRIPT
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Custom Cosmeceutical Formulations Utilizing Medical Image Analysis and
Biometric Markers
Robert P. ManzoSkinprint
1997 Rt 17MGoshen, New York 10921
845-294-8501www.skinprint.com
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� Mass Customization and Personalization is now common� Automobiles� Clothing� Shoes
� Cosmeceutical Technology & Diagnostics Have Converged� Skin diagnostics have become more user friendly� Medical imaging has become more accessible� Cosmetic active ingredients are efficacious� Consumers are more educated� Demographics are creating demand
Background
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3 Types of Pigmentation
.
A specific combination of biometric
measurements and imaging will yield
optimal results in most cases
Imaging
� High resolution macro photography � Color ultraviolet reflectance
photography
Epidermal Biometrics
� Hydration� pH� Elasticity & Firmness� TEWL (Barrier)� Sebum� Melanin and redness
Customized/Personalized Cosmeceutical Formulation
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� Wrinkles� Color tone� Stratum corneum texture� Hyper pigmentation root cause
� Oxidative damage� Melasma� Post-inflammatory hyper pigmentation� Melanin banding patterns
� Pore size� Bacterial presence (UV)� Determination of epidermal vs. dermal Melasma (UV)� Product occlusion� Lesion count
Imaging Quantitative Markers
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Confidential
Subject with Melasma and minor oxidative damage (sun damage)
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Confidential
Subject with Melasma and minor oxidative damage (sun damage) and melanin banding
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Bacterial presence
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Bacterial presence
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Confidential
Product Occlusion
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� Hydration� Dose and type of moisturizing ingredient
� pH� Bacterial proliferation (acne root cause)� Too many chemical peels (barrier function impairment)
� Elasticity & Firmness� Type and dose of collagen and elastin initiators� Dose of MMP suppressors
� TEWL (Barrier)� Humectant or occlusive moisturizer� Acne initiator
� Sebum� Acne root cause
� Melanin and redness� Baseline for in office procedures (lasers, peels, etc.)� Rosacea quantification� Healing rates
Epidermal Biometrics
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Case Study
� 46 year old subject
� Self described issues� “spots” on face� Under eye darkness and puffiness� Chronic dryness� Skin laxicity
� Medical History� Healthy, non-remarkable� Pre-menopausal� 12 year use of Retin-A
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Visible and UVCR Analysis
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Subject Biometrics Before Treatment
•Hydration 38.0 >62•pH 5.9 4.5 - 5.5•Elasticity & Firmness 47.0 >60•TEWL (Barrier) 9.0 <3•Sebum 3.0 15 - 25•Melanin 15 (spots = 36) 7 (spots = 22)•redness 46 17
Reading Optimal Range
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� Cleanser: anionic surfactant base for thorough cleansing
� 3 dimensional bio-peptide approach� Collagen I & III initiator� Fibril bundling strengthener� Matrix Metalloproteinase inhibitor
� Two phase eye treatment approach� Capillary seal� Chelant for removal of iron (hemoglobin)
� Three phase lightening approach� MSH suppressor� Tyramine competition� Tyrosinase inhibitor
� Treatment Lotion� Liposomal ursolic acid (barrier repair)� Occlusive and humectant moisturizers
Treatment Course
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Confidential
Results
� Hydration 38.0 67.0� pH 5.9 5.3� Elasticity & Firmness 47.0 56.0� TEWL (Barrier) 9.0 2.0� Sebum 3.0 4*� Melanin 15 (spots = 36) 8 (spots = 25)� redness 46 17
Before After
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Results
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Results
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1997 RT 17M
Goshen, New York 10924
845-294-8501
www.skinprint.com
Robert Manzo