v

ABSTRAK

Telah dilakukan pengujian efek ekstrak etanol daun dewa (Gynura pseudochina

(L) D.C.) dan rimpang temu ireng (Curcuma aeruginosa Roxb.) terhadap jumlah

trombosit, eritrosit, dan kadar hematokrit pada tikus putih galur wistar dengan

metode induksi heparin. Ekstrak diberikan dengan cara oral selama 7 hari

berturut-turut, dosis ekstrak etanol daun dewa 250mg/kgBB dan 500mg/kgBB;

ekstrak etanol temu ireng 250mg/kgBB dan 500mg/kg BB. Pengamatan parameter

– parameter tersebut dilakukan pada hari ketujuh dengan menggunakan alat

sysmex XE-5000 hematology analyzer. Hasil penelitian terhadap jumlah trombosit

menunjukkan bahwa ekstrak etanol daun dewa pada dosis 500mg/kgBB dan

rimpang temu ireng pada dosis 250mg/kgBB dan 500mg/kgBB memiliki

perbedaan nyata terhadap kontrol negatif pada taraf nyata α=0,05 dimana

peningkatan jumlah trombosit paling baik yaitu ekstrak etanol rimpang temu ireng

dosis 500mg/kgBBdenganpersentase 26,98% terhadap kontrol negatif, hasil

penelitian terhadap jumlah eritrosit dan kadar hematokrit menunjukkan bahwa

ekstrak etanol rimpang temu ireng pada dosis 500mg/kgBB dan daun dewa pada

dosis 250mg/kgBB dan 500mg/kgBB memiliki perbedaan nyata terhadap kontrol

negatif pada taraf nyata α=0,05 dimana peningkatan jumlah eritrosit yang paling

baik yaitu ekstrak etanol daun dewa dosis 500mg/kgBB dengan persentase

peningkatan jumlah ertirosit terbesar 17,27% terhadap kontrol negatif, dan

peningkatan kadar hematokrit yang paling besar yaitu ekstrak etanol daun dewa

dosis 500mg/kgBB dengan persentase peningkatan kadar hematokrit sebesar

10,97% terhadap kontrol negatif.

Kata Kunci: Dewa, (Gynura pseudochina (L) D.C.), Temu ireng, (Curcuma

aeruginosa Roxb.) Trombosit, Eritrosit, Hematokrit

FAKULT

AS FARM

ASI

UNIVERSIT

AS PADJA

DJARAN

vi

ABSTRACT

The aim of this research was to determine the effects of ethanol extracts of dewa

leaves (Gynura pseudochina (L) D.C) and temu ireng (Curcuma aeruginosa

Roxb.) against the number of trombocytes, erythrocytes, and hematocrit level on

male white rats (Rattus novergicus) by using Heparin Induction Method. Extracts

was given orally for 7 continous days, dosages used for dewa leaves ethanol

extracts were 250 mg/kgBW and 500 mg/kgBW, the temu ireng rhizome ethanol

extracts dosages used were 250 mg/kgBW and 500 mg/kgBW. Observation of the

parameters was tested on seventh day with using sysmex XE-5000 hematology

analyzer after the extracts was given. The result showed that the rats group which

are given extracts of dewa leaves 500mg/kgBW; temu ireng rhizomes on

250mg/kgBW and 500mg/kgBW groups gave a significant differences in numbers

of trombocytes againts negative control group (α=0,05). Temu ireng rhizome

extracts at dosage 500mg/kgBB gave the highest effects in increasing rats

trombocytes number against negative control with a percentage value 26,98%.

The rats group which are given extracts of dewa leaves on 250mg/kgBW and

500mg/kgBW; temu ireng rhizome on 500mg/kgBW groups gave a significant

differences in numbers of eritrocytes and hematocrit’s level against negative

control group (α=0,05). Dewa leaves extracts at dosage 500mg/kgBW gave the

highest effects in increasing rats eritocytes number against negative control with

a percentage value 17,27%, while improvement rate of hematocrit that is dewa

leaves extracts on 500mg/kgBW gave the highest effects against negative control

with percentage 10,97%.

Keyword :Dewa, (Gynura pseudochina (L) D.C), Temu Ireng, (Curcuma

aeruginosa Roxb.) Trombocyte, Eritrocyte, Hematocrit

FAKULT

AS FARM

ASI

UNIVERSIT

AS PADJA

DJARAN