gute chemie. welcome to abcr. - inter-chem.pl · 28,086 14 si silanes, silicones and compounds, or...

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260,000 Specialty chemicals from grams to tons & service – all from a single source – just one click away: www.abcr.de

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› › ›

abcr. Gute Chemie is your complete service provider for special chemicals.

The company is a family-run business based in Germany that specializes in sales, production and research & development on behalf of customers. Our customers include almost all well-known companies in the pharmaceuticals and chemical industries, as well as universities. We offer over 260,000 organic, inorganic and organometallic chemical products in our online shop. We synthesize substances on behalf of our customers in our laboratories and production facilities in Germany and Europe, and also rely on an international network of qualified suppliers. Whether you need a few grams or several tons of a certain product - we deliver worldwide - safely and reliably.

Gute Chemie – created in Germany & Europe. www.abcr.de

Gute Chemie.Welcome to abcr.

abcr GmbHIm Schlehert 1076187 KarlsruheGermany

Phone +49 721 95061- [email protected]

Commercial Organofunctional Silanes for

Diagnostics and Separation 01 Gute Chemie

p-F-HHSiD an excellent M3 selective tool for muscarinic receptor studies

p-F-HHSiDp-Fluoro-hexahydro-sila-difenidol hydrochloride

› Related Categories: Antagonists, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Anticholinergics.2,4

› Most competitive price › Best quality › Similar products available upon request

F

SiHO N

HCl

Literature on the preparation and application of organozinc reagents:1) G. Lambrecht, R. Feifel, M. Wagner-Röder, C. Strohmann, H. Zilch, R. Tacke, M. Waelbroeck, J. Christophe, H. Boddeke, E. Mutschler, European Journal of Pharmacology 1989, 168, 71-80.2) A. C. Kruse, J. Hu, A. C. Pan, D. H. Arlow, D. M. Rosenbaum, E. Rosemond, H. F. Green, T. Liu, P. S. Chae, R. O. Dror, D. E. Shaw, W. I. Weis, J. H. Wess, B. K. Kobilka, Nature 2012, 482, 552– 556.3) http://en.wikipedia.org/wiki/Muscarinic_acetylcholine_receptor_M3; last accessed on June 4th, 2014 4) http://www.ncbi.nlm.nih.gov/gene/1131; last accessed on June 4th, 2014

AB 357493

CAS: 175615-76-6 (HCI)CAS: 116679-83-5 (free base)Assay: min. 98 % (HPLC)Appearance: white to beige powder

Hexahydro-sila-difenidol analogues are identified as a powerful tool for the characterization of muscarinic receptor subtypes.1

Hexahydrosila- difenidol analogues

Rat M3 muscarinic acetylcholine receptor lysozyme fusion protein with bound tiotropium.3

SiHO

HCI

N

F

Silicon

28,086

14

SiSilanes, Silicones and Inorganic Silicon Compounds

Gute Chemie

AB101280 Ruthenium(III) chloride hydrate 14898-67-0

.x H2OCl RhCl

Cl

AB101821 Hexachloroiridic(IV) acid hydrate 110802-84-1

.x H2OIr

ClCl

ClCl

Cl

ClH2

AB106079 Iridium(III) chloride hydrate (99.9%-Ir) 14996-61-3

.x H2OCl Ir Cl

Cl

AB113017 Chlorotris(triphenylphosphine)rhodium(I); 99% - Wilkinson‘s Catalyst

14694-95-2 ClRh

PPh3Ph3PPPh3

AB116702 Tetrakis(triphenylphosphine)palladium(0); 99.9% 14221-01-3

PdPPh3

PPh3Ph3P

Ph3P

Highly Effective Catalysts Co-catalysts and Precursors containing Ru, Rh, Pd, Ir

zertifiziertes Qualitätsmanagementsy

stem

O

OIr Ir

High Purity Metals 5N, 6N, 7N

Gute Chemie

abcr has been supplying specialty chemicals to pharmaceutical and chemical companies worldwide since 1987. As a “preferred supplier” for many prominent customers, we focus on individual needs and professional services in a friendly atmosphere.

One focus of abcr is high purity metals for the electronics and semiconductor industry. abcr has the highest purity available in the world for a variety of metals. abcr and Osaka Asahi work together to support our customers and provide expert knowledge. We can not only offer quantities for research and development, but also bulk quantities for commercial supply. Osaka Asahi have been focusing on manufacturing high purity metals since 1958.The high purity metals are available as ingots, shots, rods, tapered rods, chunks, and powders. Please specify the size in detail; we can inform you about the variety of sizes available.

Compound (Formula) CAS 5N Grade (99.999%)

6N Grade (99.9999%)

7N Grade (99.99999%)

Aluminum (Al)Main Applications:

LEDs

[7429-90-5]

Antimony (Sb)Main Applications:

DopantCompound semiconductor (InSb, GaSb)Epitaxy source for MBESolder for semiconductorsPeltier effect

[7440-36-0]

Bismuth (Bi)Main Applications:

Peltier effectSuperconductivity

[7440-69-9]

Cadmium (Cd)Main Applications:

Compound semiconductor (CdTe)Epitaxy source for MBESolar batteriesLEDsRadioactive detectorsInfrared detectors

[7440-43-9]

99,999%


stem

99.99999%Potassium Trifluoroborates

Gute Chemie

BF3Ks have been an amazing success but their scale-up pointed out structural anomalies.

The answer to this issue came from the Molander’s team who provided BoroChem a preview of the following information as part of their Scientific Board and the details will soon be published (1).

To summarize, aminomethyltrifluoroborates are not free bases but internal salts (zwitterionic ammoniometyltrifluoroborates with small amounts of KBr):

The products keep their amazing possibilities, especially in Suzuki cross-couplings.

AB 261034 Potassium trifluoro[(piperidin-1-yl)methyl]borate; 95% 888711-54-4

N BF3K

AB 289390 Potassium N-tert-butyl-aminomethyltrifluoroborate 1256366-05-8

N BF3K

H

AB 289391 Potassium N-cyclohexyl-aminomethyltrifluoroborate 888711-52-2

N BF3K

H

Br BF3K

R'HN

R''

R'N

R''H

BF3

Reaction conditions

N BF3R''

R'H X (Het)Ar N (Het)Ar

R''

R'[Pd]cat

Base


stem

O

N BF3K

Gute Chemie

AB-Nr. Molecular Weight (MW)

Regio- regularity (RR)

Polydispersity Index (PDI)

Comment Available packaging sizes

AB 391155 50000-70000 91-94% 91-94% 2.0-2.5 1g; 5g; 10g

AB 391156 50000-70000 91-94% 2.0-2.5 additionally purified 1g; 5g; 10g

AB 391157 60000-75000 96% or above 1.7-1.9 1g; 5g; 10g

AB 391159 60000-75000 96% or above 1.7-1.9 additionally purified 1g; 5g; 10g

AB 391160 34000-41000 90-94% 1.6-1.8 1g; 5g; 10g

AB 391161 34000-41000 90-94% 1.6-1.8 additionally purified additionally purified


stem

P3HT a versatile material for electronic devices

Poly(alkylthiophene)s are known as electrically conductive polymers ("synthetic metals").

Potential applications:

Solar cells Photochemical resists Electroluminescent devices Non-linear optical devices Batteries Diodes Chemical sensorsS n

CH3 Poly(3-hexylthiophene-2,5-diyl), regioregular

CAS: 104934-50-1

01Available in bulk quantities Fluoro Organic Intermediates

H2NFF

F

CI

New Organozinc Reagents for Organic Synthesis

F

01

01Palladium catalysts for C-C and C-N coupling reactions

Pd

P

ClCl

Fe

P

Advanced Ceramic Powders

Gute Chemie

ISO 9001:2008

DIN EN ISO 9001

abcr has been the exclusiv partner for the small quantities supply for H.C. Starcks Ceramic Powders for more than 15 years. We supply individual units adjusted to your R&D and production process worldwide from our warehouse. abcr has taken over the order and distribution responsibilities for quantities of 100 grams up to 100 kilograms worldwide.

abcr Gute Chemie – since our foundation in 1987 – has meant for us: good products and people who provide good services. We also supply Gute Chemie with more than 250,000 specialty chemical products, such as H.C. Starck ceramic powders.

Gute Chemie connects.Advanced Ceramic Powders from H.C.Starck

Borides: LaB6 • SiB6 • TiB2 • ZrB2

Boron: amorphous + crystalline

Carbides: B4C • Cr3C2 • Beta-SiC • TiC • ZrC

Nitrides: AIN • BN • Si3N4 • TiN • Ti(C,N)

Silicides: MoSi2

Oxides: Y2O3

Alpha-SiC powders

Alpha-SiC Premix (ready to press)

Alpha-Si3N4 Premix (ready to press)

Including H.C. Starck Ceramics in Selb with:

Including H.C. Starck GmbH in Goslar with:

Small quantities from a few 100 grams up to 100 kg available from abcr stock

Orders placed directly via webshop abcr.de, shipments sent to your address without intermediate storage

No minimum order value, you will be charged only for the quantity you order

Material shipments include the H.C. Starck Certificate of Analysis and MSDS

Short delivery times, typically within 1 - 2 days, ex works, shipped with high delivery reliability

Payment possible by bank transfer and credit card (Visa, Master Card)

The H.C. Starck Technical Service will continue to be at your disposal 3039

21.0

415.

3

SicherheitGlove Bags aus Polyethylen erleichtern das Arbeiten mit gefährlichen, luft- oder feuchtigkeitsempfi ndlichen Sub-stanzen. Aber auch übelriechende Stoffe können darin gehandhabt werden, ohne den Experimentator und die Umwelt zu gefährden. Glove Bags werden ähnlich wie eine Glove-Box verwendet, sind jedoch wesentlich vielseiti-ger. Sie können viel schneller mit Inertgas befüllt werden und verbrauchen darüber hinaus weniger Gas. Oftmals sind sie wiederverwertbar.

HandhabungDie Handhabung ist einfach: Glove Bags werden mit den notwendigen Arbeitsutensilien durch die Einfüllöffnung beschickt, per Clip verschlossen und mit Inertgas über den Gasanschluss befüllt (die Öffnungsmaße der Tabelle wurden alle liegend ermittelt).

Vorteile Erleichtert die Arbeit in jedem Labor Trägt zur Sicherheit des Benutzers bei Schont die Umwelt

Glove Bag –Einfach sicher

1 Zunächst muss die Glove Bag mittels eines Schlauchs an eine Inert-gasfl asche (N2 oder Ar) angeschlossen werden.

2 Danach stellen Sie die notwendigen Utensilien (z. B. Chemikalien, Waage, Spatel …) in die Glove Bag und spülen mit dem Schutzgas.

3 Die Glove Bag wird jetzt mit einem Verschlussclip geschlossen und danach mit Argon bzw. Stickstoff gefüllt; nun kann die Arbeit beginnen.

4 Nach dem Benutzen die Glove Bag zusammenfal-ten und bis zur nächsten Anwendung aufbewahren. Und das beliebig oft bis zur Entsorgung.

Die Funktion:

CatalogueSilanes

OrganozincReagents

PalladiumCatalysts

SiliconCompounds

Silanes Muscarinic

P3HT for electronic devices

Glove BagFlyer

H.C.StarckProducts

High PurityMetals

Potassium Trifluoroborates

Highly EffectiveCatalysts

Fluorinated Compounds

OTf

TMS

CsF

CO2R

ArO

R

Ar

O

CONR2

O

R1

R2

Ar

R

NN

N

R

ON

R

NNR2

R1

NN

R

TsN

R1

R2

R1

CO2R2

O

N

R1

R2

R3

NR1

R2

R3O O

R

etc.

MeCNrt

Organofunctional Silanes

Aryne Precursors

orto-(Trimethylsilyl)aryl triflates: arynes under mild reaction conditions for synthesis

The use of arynes in organic synthesis has under-gone a remarkable revival over the past few years. The key to this resurgence is the use of a method for the generation of benzyne and its derivatives under mild reaction conditions. In particular, fluo-ride-induced decomposition of orto-(trimethylsilyl)aryl triflates allows the generation of arynes in high yields, under neutral reaction conditions at mode-rate temperatures. As a result, this method has proved to be extremely useful in the synthesis of natural products, the preparation of large aromatic compounds, or the synthesis of heterocycles.

Figure 1. Some examples of structures that can be obtained in one pot from orto-(trimethylsilyl)aryl triflates via benzyne chemistry (in red the new bonds).

abcr offers a large variety of ortho-(trimethylsilyl)aryl triflates, including substituted benzyne precursors, polycyclic aryne precursors and bisaryne precursors.

Gute Chemie


stem

S

Si

OF

F F

O

O

Silanes Aryne

Life ScienceNew Chirals for Drug Design

NN

NN

01Life ScienceDrug Design

Functionalized Fluorinated Isoquinolin-1(2H)-ones for Crop Protection and Pharmaceutical Application

ISO 9001:2008

DIN EN ISO 9001

Gute Chemie

F O

NH

O

The substituted isoquinolin-1(2H)-ones are present in many natural products and pharmaceuticals [1]. On the other side, the isoquinolin-1(2H)-ones are applied in Crop Protection as active agents against abiotic stress in plants [2].

abcr GmbH presents the series of functionalized fluorinated isoquinolin-1(2H)-ones.

N

O

R3

HR1

R2

R4H

H

6-(Difluoromethyl)isoquinolin-1(2H)-one 6,8-Difluoroisoquinolin-1(2H)-one

NH

O

F

F

AB 426537CAS unknown

NH

O

F

F

AB 426541CAS 1368752-55-9

6-(Trifluoromethoxy)isoquinolin-1(2H)-one 8-Fluoro-6-methoxyisoquinolin-1(2H)-one

NH

O

OF

FF

AB 426538CAS 630423-43-7

NH

OF

OAB 426542CAS unknown

6-(Difluoromethoxy)isoquinolin-1(2H)-one 6-Fluoro-7-methoxyisoquinolin-1(2H)-one

NH

O

OF

F

AB 426539CAS 630423-41-5

NH

O

F

O

AB 426543CAS 905994-27-6

6,7-Difluoroisoquinolin-1(2H)-one 5,6,7-Trifluoroisoquinolin-1(2H)-one

NH

O

F

F

AB 400779CAS 444898-79-7

NH

O

F

F

F

AB 426544CAS 1506182-55-3

References(1) (a) Matsui, T., et. al. J. Med. Chem. 1992, 35, 3307; (b) Sunderland, P. T, et. al. J. Med. Chem. 2011, 54, 2049; (c) Busby, S. A., et. al. Chem Biol. 2011, 6, 618. (2) Frackenpohl, J., et. al., Patent WO2013004652 A1.

Fluorinated Isoquinolines

Find 260,000 specialty chemicals in our webshop: www.abcr.de

Important Fluorinated Compoundsfor chemical synthesis

Description Short name CAS Article no. Unit Packing Material

Trifluoroacetic acid; 99 % TFA 76-05-1 AB212435* 1 kg5 kg

50 kg

GlassStainless steel or glassStainless steel

Trifluoroacetic anhydride; 99,5 % TFAA 407-25-0 AB212439* 2,5 kg5 kg

35 kg75 kg

GlassStainless steel or glassStainless steelStainless steel

Ethyl trifluoroacetate; 99 % TFAE 383-63-1 AB222558* 1 kg5 kg

50 kg


Ethyl trifluoroacetoacetate; 98,5 % TFAAE 372-31-6 AB222559 1 kg5 kg

50 kg


2,2,2-Trifluoroacetamide; 99 % TFAN 354-38-1 AB223268 1 kg5 kg

35 kg


Methyl trifluoroacetate; 99 % TFAMe 431-47-0 AB255058 1 kg5 kg

25 kg


Description Shortname CAS Article no. Unit Packing Material

2,2-Difluoroacetic acid; 98 % DFA 381-73-7 AB227568 1 kg5 kg

25 kg


Ethyl difluoroacetate DFAE 454-31-9 AB255056 100 g5 kg

25 kg


Methyl difluoroacetate DFAMe 433-53-4 AB255057 500 g5 kg

25 kg


Trifluoroacetic acid and their derivatives

Difluoroacetic acids and their derivatives

Gute Chemie

ISO 9001:2008

DIN EN ISO 9001

S

O

OO

F

FF

Importand Compounds

Gute Chemie

Tetra(n-propyl)ammonium nonabromide (nPr4NBr9 ) a highly reactive and selective bromination reagent

Ph Ph

Br

BrPr4NBr9

(33 mol%)0-23 °C, < 1 min

(99%)

Advantages of Pr4NBr9 against elemental Br2 :

■ excellent selectivity ■ easy handling ■ safe storage

■ appearance: red crystals

Available at the abcr webshop

AB 400387 Tetra(n-propyl)ammonium nonabromide (nPr4NBr9 ) 1352657-69-2

N+

Br

BrBr

BrBr

Br BrBr Br

-

AB 400389 Tetraethylammonium nonabromide 1370414-03-1

AB 400390 Tetramethylammonium nonabromide 38932-79-5

AB 400391 1-Hexyl-3-methylimidazolium nonabromide 1642893-19-3

4022

36.0

515.

1

Bromination Reagents

03

Gute ChemieGreater diversity, choice and value

gute chemie. welcome to abcr. - inter-chem.pl · 28,086 14 si silanes, silicones and compounds, or...

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