gunn’s dots with rtx1 - frcrnet · originally described by robert marcus gunn in 1883, gunn’s...
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Gunn’s dots with RTX1Pr Michel Paques
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Gunn’s dots
White glistening dots found in normal eyesFirst decribed in 19th centry; few publicationsAttributed to Müller cells without histological demonstration
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Originally described by Robert Marcus Gunn in 1883, Gunn’s dots are observed
in the majority of healthy subjects up to 50 years of age
They are commonly attributed to Müller cell’s footplates
Despite their potentiel interest, no specific study yet
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Paques et al. 2014
Gunn’s dots imaging by FIAO
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Mean diameter 13.5µm ±6 Peak density ~ 200/mm2
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While their distribution remain stable, the density of Gunn’s dots slowlydecreases over years
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This suggest that they are flat and very close to the ILM
Gunn’s dots are highly anisotropic; their reflectance parallels that of
the ILM
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→ This suggests that Gunn’s dots are flat
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Franze K et al. PNAS 2007;104:8287-8292
Müller cellfootplate
ILM
Vitreous
From the Jastrow electron microscopy atlaswww.uni-
mainz.de/FB/Medizin/Anatomie/workshop/EM/EMHRetinaE.html
Müller cells footplates are much smaller and much more numerous than Gunn’s dots; However, confluence may increase their apparent size
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Ogawa K. Arch Histol Cytol 2002
Qiao et al. BJO 2005
Guinea pig
Rat
Gunn’s dots are still present over the ILM after PVD, raising doubts
that they could be hyalocytes, furthermore, few histological evidence
of a flattened morphology of hyalocytes. However, it is unclear
wether or not all hyalocytes actually detach from the ILM following
PVD
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Gunns dots are (probably) not in the retina