Growth of Stem Cells in Artificial Organs

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Growth of Stem Cells in Artificial Organs. By: Chelcy Branon. What is it?. Stem cell regrowth is a process in which a patients stem cells are taken from their body and placed on a scaffold to grow an organ in an InBreath bioreactor. - PowerPoint PPT Presentation

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<ul><li><p>Growth of Stem Cells in Artificial OrgansBy: Chelcy Branon</p></li><li><p>What is it?Stem cell regrowth is a process in which a patients stem cells are taken from their body and placed on a scaffold to grow an organ in an InBreath bioreactor. Succesfully transplanted bladders and a trachea, looking to grow heart, kidney, pancreas, etc.</p></li><li><p>ProblemsIn the United States there are over 100,000 people waiting for an organ transplant. Risk of rejection.Risk of injection.</p></li><li><p>HistoryArtificial heart devices were developed in the 1970s. Stem cell growth for artificial organs has been researched since the 1970s.In 2006, a team at the McGowan Institute for Regenerative Medicine in Pittsburgh successfully transplanted bladders grown in the lab for children with spina bifida.First synthetic windpipe was inserted into a patient in 2009.Dr. Anthony Atala and his research team at Wake Forest University Medical Center made the first lab-grown bladder.</p></li><li><p>Current State of Art30 people have received the bladder transplant with a bladder that is grown in an incubator. Takes about 6 to 8 weeks.Heart transplants are taking place in rats to successfully grow an artificial heart.June 2011 a successful trachea transplant was given to patient in Sweden suffering from cancer.Wake Forest is the worlds largest regenerative medicine research center. Currently trying to grow 22 different types of tissue: heart valves, muscle cells, arteries, and even fingers.Artificial Lung</p></li><li><p>Current continuedDr. Nicholas Kotov and his lab at the University of Michigan have grown artificial bone marrow from stem cells; even antibodies.</p><p>May 2012: Removing adult stem cells, breaking them down into fibroblasts and rerouting them to grow into whichever tissue is needed.</p></li><li><p>Saving TissueBill Weir visited Dr. Tom Nelson at a clinic in Minnesota.80% chance he will see his own cardiac tissue beating outside of his body.Took tissue from bone marrow and rerouted it into growing a heart.Used to help future injuries.</p></li><li><p>Neo-Bladder: Tengion: a Biotech company based outside of Philadelphia. Created the Neo-bladder, which has a 5-7 week growth span. It is currently in Phase ll testing. After phase lll, it will become commercially available.Artificial pancreas: 23.6 million diabetic sufferers. Doctors would restore natural control of blood glucose by giving insulin.InBreath bioreactor</p></li><li><p>LimitationsAll organs are different per person.Its much harder to grow organs that arent hollow such as kidneys, hearts and livers.Not all organs can be duplicated depending on the condition.Life expectancy.</p></li><li><p>Future DirectionUse stem cells to generate a heart. Making the prosthetics more permanent and to have longer expectancy. Better preservation when being transported to lengthen the survival of the organ. Cure for diseases and conditions such as diabetes.Growing the cells taking days, not weeks.Printing tissue organs. Inkjet cartridges are replaced with human cell and smart gel. Print out layer on top of layer to produce a 3D organ. </p></li><li><p>Bibliography"BIO-ARTIFICIAL ORGANS." Bio-Artificial Organs. 2011. Web. 26 Feb. 2012. .Burmester, Jochen Ringe, Christian Kaps, Gerd-Rdiger, and Michael Sittinger. "Stem Cells for Regenerative Medicine: Advances in the Engineering of Tissues and Organs." SpringerLink. Springer Science+Business Media. Web. 20 Feb. 2012. .Niklason, Laura E., and Robert Langer. "Prospects for Organ and Tissue Replacement." Opportunities for Medical Research. American Medical Association, 26 Feb. 2012. Web. 26 Mar. 2012. .Saenz, Aaron. "Singularity Hub - Science, Technology, The Future of Mankind." Stem Cells Used to Grow Hearts: Cool New Pics and Vid. 23 June 2009. Web. 26 Feb. 2012. .Duke Medicine News and Communications. "Newly-Identified Growth Factor Promotes Stem Cell Growth, Regeneration." - DukeHealth.org. 21 Mar. 2010. Web. 26 Feb. 2012. .Vezina, Kenrick. "First Fully Synthetic Organ Transplant Saves Cancer Patient." Technology Review. MIT, 11 Oct. 2012. Web. 11 Oct. 2011. .Halley, Drew. "Growing Organs in the Lab | Singularity Hub." Growing Organs in the Lab | Singularity Hub. N.p., 6 Aug. 2009. Web. 11 Oct. 2012. .Monroy, Bill Weir, C. Michael Kim, David Miller, Justin Bare &amp; Mark. "Grow Your Own Organs." Yahoo! News. Yahoo!, 03 May 2012. Web. 11 Oct. 2012. .</p></li></ul>