growing - sivanto.bayer.com · control severe sucking pests while ... efficacy environmental...

Growingin Unison

Growing crops with environmental responsibility & economic success

Content

About

SIVANTO® prime at a glance

Inspired by nature

Using

Safety profile

Spectrum of SIVANTO® prime

Pome fruits

Citrus

Vegetables

Coffee

The science behind

Features & benefits

Mode of action

Classification

Summary

3 - 9

10 - 11

14 - 17

18 - 19

20 - 21

22 - 23

24 - 25

26 - 27

30

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34

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01

02

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Our strong safety profile allows us to control severe sucking pests while staying mindful of the environment. SIVANTO® prime’s protective measures include strong and quick efficacy providing effective virus vector control, flexibility in method and timing of application, and resistance management of selected pests. SIVANTO® prime is highly selective and affects neither the quality of the crop nor that of the harvest, thus ensuring greater safety in agriculture and sustainable farm management.

About 01

GLANCE

6 7 8 9

Dr. Ralf Nauen Research Fellow, Bayer CropScience AG

Its unique pharmacophore system makes

SIVANTO® prime chemically distinct from

established sucking pest chemistry.

““

SIVANTO® prime at a glance SIVANTO® prime - an innovation for sucking pest control

SIVANTO® prime is a modern insecticide with an outstanding safety profile for the control of major sucking pests like aphids, whiteflies, and other key insect pests including larval and adult stages.

The active ingredient of SIVANTO® prime, flupyradifurone, belongs to Bayer CropScience’s own chemical class of butenolides.

It is a systemic insecticide which is most effective when used as foliar application, but also has excellent drench application properties.

SIVANTO® prime also has excellent safety characteristics: it is highly compatible with honey and bumblebees allowing wide application windows and treatments during flowering. Its selectivity to most beneficials in fruit and field-grown vegetable crops provides a perfect fit for Integrated Pest Management (IPM) programs.

It is a valuable tool for resistance management, in particular for selective neonicotinoid-resistant pests like whiteflies and selected aphids.

Additionally, SIVANTO® prime provides a wide range of signi-ficant benefits to growers, such as excellent speed of action, quick feeding cessation, effective virus vector control and flexible applicability at any crop stage.

Growing crops with environment responsibility and economic success

SIVANTO® delivers something new with its state-of-the-art family of insecticides. It answers the needs of value-driven fruit, plantation and vegetable growers: quick and effective care of difficult-to-control sucking pest, high safety standards and an excellent IPM fit, new resistance management tools with maximum application flexibility, and easy crop management for superior profitability of produce.

Growing in unison with the farmer

Product profile

Active ingredient: Flupyradifurone

Chemical class: Butenolide

Brand name: SIVANTO® prime

Formulation: SL 200 | Soluble liquid

Mode of action: Agonist of the insect nicotinic acetylcholine receptor (nAChR)

IRAC* classification: Group 4D

Crops: Vegetables, fruits incl. grapes, citrus and plantation crops (coffee, cocoa),

as well as cotton, soybean (seed treatment) and ornamental plants

Key pests: Aphids, whiteflies and psyllids, selected hoppers,scales, psyllids, beetles,

mirids, leaf miners and sawflies CONVENIENCE

EFFICACY ENVIRONMENTAL RESPONSIBILITY

NON-hAzARdOUS TO BEES & BUMBLEBEES

UNIqUENESSSELECTIVITY

1 2 3 4

5 6 7 8

9 10 11 12

*IRAC – Insecticide Resistance Action Committee

a b o u t s i v a n t o

10 11

Innovative pest control derived from nature for gentle usage

Inspired by nature

The creation of flupyradifurone was inspired by the natural compound stemofoline – an isolate from Stemona japonica, a medicinal plant that grows mainly in South-East Asia. Stemofoline is an alkaloid with exciting insecticidal properties. For decades, scientists around the world have tried using this knowledge to develop a com-mercial crop protection but have failed in their attempts.

Bayer’s research scientists have now succeeded in identifying which part of this complex natural product is responsible for its insecticidal action: the butenolide pharmacophore system addres-sing the nicotinic acetylcholine receptor (nAChR) in targeted pests. By combining it with two other chemical fragments, the scientists discovered that the efficacy and selectivity of the active ingredient could be significantly improved.

About 01

Stemofoline

12 13

Using 02We are bringing pest control back to its natural beginnings. SIVANTO® prime offers an uncomplicated pest control solution that is inspired by nature’s own formula.The result is a more sustainable, responsible and convenient way to grow and harvest your crops; a new concept that has never before been offered in the world of agrochemistry. SIVANTO® prime: a sustainable way to farm for more rewarding results.

Growing in unison with environmental responsibility.

14 15

Non-hazardous for humans and mammals

SIVANTO® prime’s active ingredient (flupyradifurone) has low acute toxicity when exposed through ingestion, inhalation, and dermal absorption. It is only slightly irritating to the eyes and is not a skin irritant.

According to all scientific data currently available, the agricultural use of flupyradifurone does not pose a cancer risk to humans.

Ecotoxicological profile

The intrinsic toxicity of SIVANTO® prime’s active ingredient was evaluated on a broad range of indicator species under worst-case exposure scenarios.

The results found that there are no adverse effects on non-target arthropod populations when it is used under practical conditions in the field.

Meeting the diverse safety needs of modern agriculture

02

Test type (SIVANTO® prime) Result

Acute oral toxicity, rat Ld50: 5000 mg/kg

Acute dermal toxicity, rat Ld50: > 2000 mg/kg

Acute inhalation toxicity, rat Ld50: 3.5 mg/L

Acute skin irritation: not irritating

Acute eye irritation: not irritating

Skin sensitization: sensitizing

Ecotoxicological properties on non-target organisms

Birds (bobwhite quail): Acute oral LD50 : 232 mg a.i./kg bw

Fish (rainbow trout): Acute LC50 >74.2 mg a.i./L (practical limit of solubility)

Aquatic invertebrates (daphnia): Acute EC50 > 77.6 mg a.i./L

Aquantic plants (algae): EC50 > 80 mg a.i./L

Earthworms (Eisenia) 14 day: LC50 193 mg a.i./kg dry wt soil

Safety profileUsing

02

16 17

Mar. Apr. May Jun. Jul. Aug. Sep. Oct. Nov.

00 09 10 55 56 57 59 60 65 67 69 72 74 75 79 81 87 91 93

Beneficial group Species Stage Crop Foliar drench

Predatory mites: Amblyseius swirskii Bell pepper 2 1-2

Typhlodromus pyri Motile Apple 1 Not applicable

Kampimodromus aberrans Apple/grape 1 Not applicable

Predatory bugs: Orius laevigatus Mixed Bell pepper 3 1-2

Anthocoris nemoralis Mixed Pear/corn 3 1

Coccinellidae: Coccinella septempunctata Larvae Apple 1 1

hover flies: Episyrphus balteatus Larvae Cabbage 1

Lacewing: Chrysoperla spp. Adult 1-2 1

Parasitoid wasps: Encarsia formosa/ Mixed/ 1-3 1 Eretmocerus mummies

Aphidius colemani Mixed 1 Not applicable

Aphelinus mali Mixed Apple 1-2 Not applicable

IOBC rating = International Organization for Biological and Integrated Control

Rosy apple aphid

Predatory mites (Typhlodromus pyri) 1

Aphid predators (Coccinelids) 1

2Woolly aphid parasitoid (Aphelinus mali)

Selectivityto beneficials

Pre

senc

e o

f b

enefi

cial

sP

est

infe

stat

ion

or*

*in the EU

2 3 41

non-hazardous

Analogous toIOBC rating

harmfulSlightly harmful

Moderately harmful

2 3 41

non-hazardous

Analogous toIOBC rating

harmfulSlightly harmful

Moderately harmful

No adverse effects on honey bees and bumblebees

Higher tier studies demonstrate that exposure under worst-case conditions cause no adverse effects on honey bees and honey bee colonies when applied during full bloom and when bees were actively foraging – including in the long term.

Field studies(Bee-attractive crop)

Tunnel studies(Bee-attractive crop, confined & forced exposure)

No adverse effects in honey bees and honey bee colonies when applied during full bloom and when bees were actively foraging.

Selectivity to beneficials

Positioning in IPM systems (example: in pome fruits)

Based on the recommended field rates and positioning of SIVANTO® prime, the results show that the compound is selective to most beneficials in fruit and outdoor grown vegetable crops.

Safety profile

SIVANTO® prime has been tested in laboratory and extensive semi-field and field studies using crops that are highly attractive to bees.

Acute and chronic laboratory studies show that it has a low intrinsic toxicity to adult and immature honey bees.

When applied at the proposed label rates, SIVANTO® prime presents no adverse effects on honey bees – even when applied to flowering crops.

Using

Studies indicate that SIVANTO® prime has no adverse effects on foraging honey bees, foraging activity, brood and colony development, hive vitality and honey bee health or on over-wintering colonies when used in accordance with the proposed label instructions.

Two IPM-compatible foliar applications of SIVANTO® prime to control rosy apple aphids have no adverse effects on predatory mites and coccinellidae in pome fruits

02

18 19

Whiteflies

SPECTRUM

Green peach aphids

Coffee leaf miners

Citrus thrips

Rosy appleaphids

Lygus bugs

Potato psyllids

Pear suckers

Grapevineleafhoppers

Cocoa mirids

Perennial crops (example)

Confidor

Movento

Envidor

Mites

Scales, mealybugs

Aphids

Caterpillars

Calypso

<Dormancy & Prebloom>BBCH 00-59

<Flowering>BBCH 60-69

<Summer growing>BBCH 71-89

<Fall Harvest>BBCH 91-97

<Dormancy & Prebloom>BBCH 00-59

<Flowering>BBCH 60-69

<Summer growing>BBCH 71-89

<Fall Harvest>BBCH 91-97

Caterpillars

Calypso, Belt

Mites

Confidor

Aphids

Various

MoventoOberon

Whiteflies, psyllids

Annual crops (example)

Offering protection to a wide variety of fruit, vegetable, plantation and defined broadacre crops

Whiteflies (Bemisia tabaci, B. argentifolii & Trialeurodes vaporariorum), aphids (Myzus persicae, Nasonovia ribisnigri), potato psyllids (Bactericera cockerelli)

Aphids (Dysaphis plantaginea, Aphis pomi), scales (Quadraspidiotus perniciosus), psyllids (Psylla piri)

Leafhoppers (Empoasca vitis; Scaphoideus titanus, Erythroneura spp.),grapevine mealybugs (Planococcus ficus)

Cotton aphids (Aphis gossypii),lygus bugs (Lygus spp.)

Asian citrus psyllids (Diaphorina citri),citricola scales (Coccus pseudomagnoli-arum), thrips (Scirtothrips citri)

Coffee leaf miners (Leucoptera coffeella)

Cocoa mirids (Distantiella theobroma, Sahlbergella singularis)

Grapes

Vegetables Cotton

Coffee

Cocoa

Fruits

Citrus


SIVANTO® prime is a systemic insecticide that is flexible in application and highly target-selective against a broad range of sucking pests, such as aphids, hoppers and whiteflies. It is also effective against mealybugs, leaf miners, soft scales, citrus psyllids as well as some weevils, thrips and beetles.


Crop positioning

SIVANTO® prime complements Bayer CropScience’s sucking insect solution portfolio in perennial and annual crops. It fits ideally into integrated spray programs – together with e.g. ketoenols, biologics –in our sustainable crop solutions. It answers the needs of even the most challenging spray programs.

In addition, SIVANTO® prime conveniently supports different types of application (foliar, soil, drip irrigation) and provides adaptable application timing (including during blooming).

Excellent control of key adult and immature sucking pests

Reaching a large spectrum of sucking pests in a diverse range of crops

Fits into spray programs in sustainable crop solutions

Using

Referenced products are registered for use in certain countries and national label instructions must be read and followed. Please check the approval status of SIVANTO® prime in your country. For specific instructions please consult the SIVANTO® prime product label.

02

20 21

Luk de Maeyer, Renske Petre, Christof SchoevaertsBayer CropScience BelgiumAgronomic Development Horticulture

SIVANTO® prime controls pear suckers at flowering

perfectly. It’s really a major step for maximum fruit

quality at harvest! During the development of SIVANTO®

prime we appreciated its consistency and excellent

performance in all the trials on rosy apple aphids. The

long-lasting efficacy of this pre-flowering application

was absolutely striking! Rhopalosiphum insertum aphids

were additionally controlled. A post-flower application

also controls Aphis pomi and Aphis spiraecola, and

showed useful side effects on Eriosoma.

“

“

51 DAA

L4L5 23 DAA

SIVANTO® prime 60g a.i.

Reference

Calypso 60g a.i.+Trend

0 20 40 60 80 100 % efficacy

L4L5 15 DAA

15 DAA: 170 L4L5 per 25 clusters23 DAA: 165 L4L5 per 25 clusters

g a.i./ha mCh*

SIVANTO® prime 40g a.i.

Reference

Calypso 60g a.i.

70 75 80 85 90 95 100 % efficacy

27 DAA 36 DAA 43 DAA

27 DAA: 1323 36 DAA: 494843 DAA: 5433 51 DAA: 6160

g a.i./ha mCh*

Pome fruits

Rosy apple aphids and pear suckers remain a major concern for pome fruit growers in Belgium.

SIVANTO® prime is highly effective in protecting pome fruits against these pests, which are responsible

for significant damage and quality issues each year.

Solving apple and pear problems for growers in Belgium

Efficacy on Psylla pyri[Number of larvae, Ransberg/Belgium, 2010]

Efficacy on Dysaphis plantaginea[Number of aphids, Sint-Truiden/Belgium, 2011]

Fruits: pome fruitsUsing


*meter canopy height

Asian citrus psyllid (Diaphorina citri)

02

22 23

SIVANTO® prime 102.5g a.i./ha

Thiametoxam &

chlorantraniliprole 70g a.i./ha

Sulfoxaflor70g a.i./ha

0 20 40 60 80 100 % efficacy55 DAA 50 DAA 34 DAA

0 20 40 60 80 100 % efficacy143DAA (41DAB)

97DAA 85DAA 27DAA


(A)


(AB)

Admire152.7g a.i./ha

(AB)

Standard Water

Feeding phases [%]

Non-probingPhloem ingestion*

Stylet penetrationSalivation into phloem*

Xylem ingestionPhloem penetration*

27.1

64.6

8.3 13.8

86.243.5

7.1

34.84.54.6

5.6

Citrus

Presenting a new tool for sustainable, effective citrus production

With the invasion of citrus greening disease into Brazil, the United States and other major citrus production areas, the survival of the citrus industry in the Americas is at risk. So far, there is no cure for citrus greening, a disease caused by a bacterium named Candidatus liberibacter which is transmitted by the Asian citrus psyllid (ACP) Diaphorina citri as its vector.

Fighting psyllids is still an enormous task; citrus greening continues to spread further and losses due to the disease are increasing. Available ACP

control options, especially during blooming, are limited and only marginally effective. SIVANTO® prime successfully fills this gap with fast feeding cessation that minimizes the probing of target pests and thus reduces the risk of virus and bacteria transmission.

Efficacy on Diaphorina citri[Winter Garden/FL, USA, number of adults/sweep, 2013]

Efficacy on Coccus pseudomagnoliarum[Tulare/CA, USA, number of nymphs/10 leaves, 2012]

Fruits: citrus

Frequency of Asian citrus psyllid adult feeding phases (measured by EPG** technique)

SIVANTO® prime minimizes the probing of target pests (fast feeding cessation), and thus reduces the risk of virus and bacteria transmission.

* Potential for pathogen transmission to occur** EPG = Electrical Penetration Graph

Using


SIVANTO® Standard

02

24 25

Dr. John Palumbo University of Arizona, USA

Among the newer active ingredients recently developed for

whitefly and CYSDV management (e.g. Cyazypyr, sulfoxaflor),

SIVANTO® prime is clearly the most effective and has the

best fit in desert melon IPM programs. In experimental trials

conducted over the past five years, soil at-planting applications

of SIVANTO® prime have provided excellent residual control of

immatures and adults. When used in conjunction with a foliar

spray program, these applications have provided as good as

or significantly better reductions in the incidence of CYSDV on

fall melons than the industry standard.

“

“

Dr. José Antonio Garzon, Universidad Autónoma de Sinaloa, Mexico

I‘ve had a higher yield and better

fruit quality at harvest since using

SIVANTO® prime in my trials. Many

colleagues have asked me many times

what I have applied to

my tomatoes.

“

“


Cyantraniliprole 110g a.i./ha

Sulfoxaflor100g a.i./ha

SIVANTO® prime 205g a.i./ha

0 20 40 60 80 100 % efficacy 16 DAC

16DAC: 118 infected plants/40 feet | all treatments with DYNE-AMIC 0.25%

Application: 27/05/2013; 03/06/2013; 11/06/2013

Efficacy on virus infection[% virus infected plants]


Standard 1150g a.i./ha

Standard 2200g a.i./ha

0 10 20 30 40 % infection

Application: 03/01/2013;

7DAA: 10; 14DAA: 3021DAA: 90; 49-77DAA: 100

21 DAA 14 DAA

77 DAA 49 DAA

7 DAA

Vegetables: Melon

A major concern for cantaloupe melons is the difficult-to-control whitefly (Bemisia tabaci) and the damage caused by the Cucurbit Yellow Stunting Disorder Virus (CYSDV) it transmits. SIVANTO® prime directly manages the problem of both whiteflies and CYSDV while allowing production of cantaloupe melons to thrive.

Controlling whiteflies and CYSdV in Western melons

Efficacy on Bemisia tabaci[Number of virus-infected plants, Yuma/AR, USA, 2013]

Vegetables: tomatoes

Whiteflies and aphids are major pests on tomatoes that transmit several viruses and permanent yellowing diseases. SIVANTO® prime applied to foliage provides rapid knockdown of whiteflies and potato psyllid adults. Furthermore, it has been demonstrated in various trials that when SIVANTO® prime (400g a.i./ha) is applied as a drench after transplanting, a lower number of plants with diseases transmitted by sucking pests is observed. In addition, more tomatoes with greater overall fruit quality are harvested.

Trial set-up: Tomato Yellow Leaf Curl Virus (TYLCV, transmitted by whiteflies), comparison of SIVANTO® prime with neonicotinoid insecticides; data generated 2012 by Dr. José Antonio Garzon, Universidad Autónoma de Sinaloa, Mexico

Vegetables: melons | tomatoesUsing

higher share of marketable tomatoes due to SIVANTO® prime’s rapid control of virus vector transmission in Mexico

Visual comparison 76 days after application

02

26 27

Rodolfo San Juan and Francisco Lozano, Agronomic Development, Bayer CropScience Brazil; Elias Tapia, Marketing Insecticides, Bayer CropScience Region Latin America

SIVANTO® prime is a flexible compound which does not create any

effects on predatory mites and is selective to beneficials in coffee. It

is an excellent tool for integrated programs in alternation with other

compounds. Besides its efficacy, we have observed an outstanding

vigor-enhancing effect, especially in young plantings, giving significant

growth promotion, and with that, an earlier harvest of the crop. Other

products used in coffee often cause mites to flare up.

We have not seen this effect with SIVANTO® prime.

“

“

70 DAB

50 DAB 20 DAB

80 DAB

SIVANTO® primeat proposed field dosage

400g a.i./ha

Standardat 250g a.i./ha

0 20 40 60 80 100 % efficacy

Application: 30/11/2011; 03/02/2012;


SIVANTO® prime150g a.i./ha

Chlorantraniliprole31.5g a.i./ha

0 20 40 60 80 100 % efficacy

Application: 06/12/2013;

13DAA: 13 %; 28DAA: 19%41DAA: 18.8%; 83DAA: 47.9%

41 DAA

28 DAA 13 DAA

83 DAA

Coffee leaf miner (Leucoptera coffeela)

drench foliar

Sep. Oct. Nov. Dec. Jan. Feb. Mar. Apr. May. Jun.

Coffee

The coffee leaf miner (Leucoptera coffeella) makes its home in coffee trees. Digging into the leaves, this pest creates large brown spots. Rubbing and bending an infested leaf will break it apart and often expose the presence of tiny larval miners.

Leaves damaged by this pest typically die and drop off the tree early, impacting the tree’s ability to produce coffee beans. SIVANTO® prime is used not only as a foliar treatment but also as a soil application in order to maximize its long-lasting efficacy against coffee leaf miners.

Excellent control of coffee leaf miners through versatile application methods

Coffee in Ituverava area Riberao Preto/ Brazil

Coffee leaf miner (Leucoptera coffeella)

Soil efficacy on Leucoptera coffeela[Mined leaf %, Araguari/Brazil, 2012]

Foliar efficacy on Leucoptera coffeela[Mined leaf %, Ituverava/Brazil, 2013]

Growth stages

Plantation: coffeeUsing


28 29

The Science behind03

Growing in unison with your harvest

We are making day-to-day farm management more successful and convenient. Considering every detail – from distribution on your crops to speed of efficacy – SIVANTO® prime doesn’t leave anything to chance.The long-lasting efficacy of SIVANTO® prime ensures long-term protection of your crops resulting in higher-quality produce at harvest.SIVANTO® prime: finding new ways to bring out the best in your crops.

03

30 31

Improvedcold stability

20%a.i.

40%Others

40%uniqueemulgator

Excellent

spontaneity Adva

nced

rete

ntio

n

Easy handling and storage

Rapid solubility and good miscibility in

the spray tank

high bioavailability and enhanced plant penetration

for rapid activity

Droplet placement

Leaf cross-section: Translaminardistribution throughout the leaf.

Insects controlled at the base on the bottom of the leaf.

Insects controlled on the distal end on the bottom of the leaf.

Contact & feeding Translaminar

Crop Pest Rate Contact & feeding

Crop Pest Rate Trans- laminar

Pepper Myzus persicae 60g a.i./ha ++++

Pepper Myzus persicae 12g a.i./ha ++++

Cotton Aphis gossypii 75g a.i./ha +++

Cabbage Myzus persicae 75g a.i./ha ++++

spray droplet on upper leaf surface

active ingredienttranslocation

spray droplet on lower leaf surface

A novel formulation concept for convenient and efficient farm management

Using a unique formulation concept, SIVANTO® prime 200 SL (soluble liquid) is based on a specifically tailored emulgator system that has never been used before within the agrochemical industry.

Translaminar and xylem-systemic movement

SIVANTO® prime’s active ingredient is taken up into the leaves and stems with spray application and via the roots when applied to soil or alternative substrates. After absorption into the plant, SIVANTO® prime is translocated acropetally in the xylem, in the direction of the transpiration stream, and is translaminarily distributed into adjacent plant cells.

due to this translaminar movement, it is successful against insects feeding on the underside, even when applied only to the topside of the leaf.

Contact, feeding and translaminar efficacy

Compared to standard competitors, SIVANTO® prime provides very fast feeding cessation(measured by honeydew excretion) even on aphids feeding on the underside of leaves.

hard-to-reach spots and pests are no longer a problem

Foliar application: SIVANTO® prime’s systemic translocation properties distribute the active substance rapidly throughout the leaves to reach even hidden pests.

The formulation of SIVANTO® prime is easy to handle and store thanks to its improved cold stability and provides rapid solubility and good miscibility in the spray tank due to the excellent spontaneity of its formulation. After spray application the advanced retention properties result in high bioavailability of the compound and enhanced plant penetration to ensure rapid activity of the active ingredient.

The Science behind Features & benefits

03

32 33

Days afterdrench

application1 4 8 142 5 9 ...3 7 ...6 10 24

Numbers and letters indicate leaf positions: c = cotyledons | leaf 1 = oldest leaf | 12 = youngest leaf | f = flowers

Uptake and distribution of 14C-labelled (*pyridinylmethyl-14C) SIVANTO® prime a.i. formulated as SL200 after soil drench application of 24 mg a.i./ plant at 80-90% water holding capacity 1 to 24 days after treatment (dat); exposition time 6 days.

Two droplets on either side of the

midrib of two center pinnate leaves

One droplet on main stem above leaf 8

Single droplet on center midrib of leaf 7

1 dAT 4 dAT

Uptake and distribution of [pyridinylmethyl-14C]-labelled FPF formulated as SL200 after defined droplet applications on different leaf parts of tomato plants grown at 50% water holding capacity 1 and 4 days after treatment (dat). White rings indicate application points; exposition time 3 days.

1 Bq 2,5 Bq 5 Bq 10 Bq 25 Bq 50 Bq 100 Bq

1 Bq 2,5 Bq 5 Bq 10 Bq 25 Bq 50 Bq 100 Bq

Mode of action

As an agonist of the insect nicotinic acetylcholine receptor (nAChR), flupyradifurone mimics the natural neurotransmitter acetylcholine.

Nerve connections in the central nervous system of insects.

Neurotransmitter release from pre-synaptic vesicles and their binding to post-synaptic nAChRs.

SIVANTO® prime binds to and opens the post-synaptic nAChR.

In contrast to the natural neurotransmitter the active substance of SIVANTO® prime cannot be inactived by the respective enzyme, causing excitation of the nerve cell. The lasting effect of the product results in a disorder of the insect nervous system and subsequent collapse.

due to take-up through the roots and rapid distribution within the entire plant, SIVANTO® prime is ideal for drench applications.

Systemic translocation after drench application

Systemic translocation after foliar application

SIVANTO® prime’s systemic translocation properties distributes the active substance rapidly throughout the leaves to reach even hidden pests.


03

34 35

Flupyradifurone

Butenolides

Imidacloprid

Thiamethoxam

Clothianidin

Dinotefuran

Nitenpyram Thiacloprid

(E=SCH2CH2)

Acetamiprid

(E=CH2)

IRAC classification

Nitroguanidines Nitromethylenes N-cyanoamidines

Neonicotinoids

Sulfoxaflor

Sulfoximines

The butenolide

pharmacophore is a

new bioactive scaffold

for commercial nAChR

agonists.

4A

4C 4d

N

CI

N

F

F

O

O

N N

NNO2

##

# #

N E

NCN

#

#

NF3CN

S

O

CN

N N

NO2

##

# #

Classification

Flupyradifurone is an agonist of the nicotinic acetylcholine receptor (IRAC MoA Group 4). It binds to the nAChR but with a different pharmacophore than neonicotinoids (4A) and sulfoximines (4C). Thus, flupyra-difurone presents little to no metabolism-based cross-resistance with neonicotinoids in target species.

However, target-site mutation-based cross-resistance affects all compounds within IRAC group 4. This results in loss of sensitivity in target pests. Therefore, a clear resistance management strategy has been developed to keep SIVANTO® prime working against neonicotinoid-resistant populations (e.g. whiteflies).

With its unique pharmacophore system, flupyradifurone is chemically distinct from neonicotinoid insecticides and sulfoxaflor

An innovation for sucking pest control

SIVANTO® prime

A modern insecticide with an excellent safety profile for the control of major sucking pests including selected neonicotinoid-resistant pest populations (e.g. whiteflies, selected aphids)

Non-hazardous to honey bees and bumblebees allowing wide application windows; an innovation for sucking pest control and treatments during flowering

Selectivity to most beneficials in fruit and outdoor grown vegetable crops provides a perfect fit for IPM programs

Fast activity leading to quick feeding cessation provides effective virus vector control

The unique butenolide chemistry even allows applications against selected neonicotinoid-resistant pest populations

Favorable crop compatibility and applications at any crop stage give full flexibility in optimizing successful and easy farm management.


1 2 3 4

5 6 7 8

9 10 11 12

Growingin Unison

Referenced products are registered for use in certain countries and national label instructions must be read and followed. Use plant protection products safely. For further product information visit www.cropscience.bayer.com.

Please check the approval status of SIVANTO® prime in your country. For specific instructions please consult the SIVANTO® prime product label.

SIVANTO® prime and other referenced products are trademarks of Bayer AG.

Bayer CropScience AG Alfred-Nobel-Str. 50 D - 40789 Monheim am Rhein Germany

www.sivanto.bayer.com

© Bayer CropScience · June 2014

www.sivanto.bayer.com

growing - sivanto.bayer.com · control severe sucking pests while ... efficacy environmental...

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