greentech(presenta0on€¦ · may 2015. march)2017 phytosterols ecdysone (12%) mw 464.63 g/mol logp...

GREENTECH presenta0on

©GREENTECH -‐ DOC 03_904 V01/17

March 2017

Europe trends in cosme0cs

‣A"rac&on for natural ingredients Our por5olio Zoom on the charcoal

‣ Use of probioDcs

‣ Always looking young Zoom on the masks phenomenon

‣ Hair care products Zoom on « low poo » products

‣ PersonalizaDon and ethnical beauty

A8rac0on for natural ingredients

March 2017

Organic cosme0cs

‣ Revenue of the market for organic skin care products expected to grow at a rate of 9,9% from 2012 to 2018

‣ Products with natural ingredients: more prone to microbial a[acks

Top factors impacting world cosmetics market

↗ Rate of use of natural ingredients by 2022

March 2017

GREENTECH’s answer

ACTIVE INGREDIENTS: Liquid, Pasty, Solid •Titrated in acDve molecules / purified molecules •Quality et traceability: tracer of acDvity and idenDficaDon •In tubo, vitro, vivo tests for efficiency •New technology: CryoextracDon, Chromatography, Soc extracts…

INGREDIENTS: •SOFT BUTTERS, OILS •EXTRACTS: on different supports for several formulaDons •SPECIFIC WATERS: seawaters, fresh waters… •SCRUBS •OTHERS: DisDllates, essenDal oils… •For history MarkeDng of the plant, the origin

More than 3 000 ingredients from any natural sources

March 2017

Zoom on the charcoalCoal se"les into our beauty rou&ne to purify and detoxify deeply our skin. Masks, micellar water, toothpaste ... It is found in various hygiene and beauty products.

History :

The use of charcoal in

cosmetics is very old. Evidence

of its use goes back to

antiquity. The first archives of

its use in skincare products

date from the XIXth century.

Do not confuse :- Black carbon : used as a base

pigment in black make-up products such as eye pencils, eye-liners or mascaras.

- Active plant charcoal : now widely used in a multitude of treatments

Vegetable charcoal properties :- absorb bacteria and toxins- alleviate body odors- detoxify the epidermis

March 2017


‣ A[racDon for natural ingredients Zoom on the charcoal

‣Use of probio&cs BIOTILYS®




Use of probio0cs

March 2017

Probio0cs

‣ Emergence of food-‐based and probioDc facial skincare

‣In cosmeDcs, no standardised defini&on of probioDcs

‣ ProbioDcs : microbes added to formulaDons

According to the CEO of The South African ESSE which markets products containing live probio=cs., the company is growing at an

impressive 300% per annum.

March 2017

DEFINITION: ProbioDcs are live microorganisms that may confer a health benefit on the host

Balance our immune system

Enhance the intes&nal barrier func&on

Prevent intes&nal barrier dysfunc&on

Inhibit the growth of some pathogens

Probio0cs

Regulate intes&nal homeostasis

Probio0cs

March 2017

“Protects your skin under any

circumstances”

Issued from probio0cs

BIOTILYS®

March 2017

Barrier homeostasis maintenance for a beau0ful skin

‣ Protects the skin from the first applicaDon

‣ Protects the skin in a long-‐term way

‣ Helps the skin to repair faster

‣ Improves skin moisturizaDon

‣ Increases skin radiance

‣ Reduces shiny skin

SKIN HYDRATION RADIANCE, LUMINOSITY,

YOUTHFULNESS

BIOTILYS®

March 2017

BIOTILYS® for an immediate and

op0mal protec0on

BIOTILYS® : test on volunteers

ColdTemperature

Wind Excessive heat Washing

Allergens

Daily environmental a"acks

Pathogens

March 2017

BIOTILYS® : ma8ifies shine and illuminates

skin

AXer only 3h, BIOTILYS® decreases the skin shininess in 87% of the

volunteers

AXer 7 days of applica&on, BIOTILYS® increases the radiance of the skin in

87% of the volunteers

Before AXer one week of use

BIOTILYS® : test on volunteers

March 2017

Complete range of skin care -‐ Protec=on

Face cream -‐ Protec=on, An=-‐redness

BIOTILYS® in the market

March 2017




‣Always looking young LIFTISS®, REVERSKIN®, SOLIBERINE® Zoom on the masks phenomenon



Always looking young

March 2017

Looking young

‣ Good looks : sensaDon of well-‐being, posiDve self-‐esteem

‣Health : increasing concerns about skin cancer and prevenDng signs of aging

‣Emerging trends in anD-‐aging is in hair care

March 2017

LIFTISS®Immediate effect on wrinkles surface

March 2017

• Issued from Baobab pulp

• Sustainable development and fair trade: the major product from the Burkina Faso chain

Tensor -‐ Immediate liRing effect Instant an0-‐wrinkles effect to get a revitalized and liRed skin

LIFTISS®

March 2017

• 20 volunteers : smoothing effect 5 min acer the applicaDon of formula containing 5% LIFTISS®

• Analysis by profilometry on eye contour area

‣ For 72% of volunteers, LIFTISS® allows decreasing the furrows number of the microrelief by -‐ 41%

‣ For 67% of volunteers, LIFTISS® allows decreasing the wrinkled surface by -‐ 24% ‣ For 61% of volunteers, LIFTISS® allows decreasing the deep wrinkles number by -‐ 8%

‣ For 67% volunteers, LIFTISS® allows decreasing medium wrinkles number by -‐7%

T0 T5min

LIFTISS® : test on volunteers

March 2017

SENSORIAL TEST

Tensor/lifting effect

No tensor/lifting effect

Improvement in cutaneous aspect

No improvement in cutaneous aspect

• 67% volunteers felt an immediate liXing effect

• More than 60% volunteers felt an improvement in cutaneous aspect

LIFTISS® : test on volunteers

March 2017

An=-‐aging eye essence -‐ Firming

Eye serum -‐ Firming, LiHing

LIFTISS® in the market

Radiance resurfacing care -‐ Renewing, Revealing,

Refining

May 2015

March 2017

PHYTOSTEROLS

Ecdysone (12%)

MW 464.63 g/mol

LogP 2.92

• Issued from a tropical fern named metuapua’a in French Polynesia (Microsorum grossum)

One of the most frequently used fern species in Polynesian traditional medicine Rich in a phytobioactive agent namely phytoecdysones obtained by adsorption chromatography

GREENTECH uses it for the first time in cosmetics

REVERSKIN®

March 2017

Recreates volume and relief of young skin

Restores stratum corneum cohesion and skin barrier integrity

Strengthens the basal membrane

SDmulates definiDon and cohesion of the DEJ

Maintains the structure, funcDon and stability of the ECM

Improves the elasDcity, the density and the firmness of aged skin

APPLICATIONS: An&-‐aging skin care -‐ Regenera&ng, densifying, an&-‐

wrinkling, firming, and restoring benefits

REVERSKIN®Reverses the signs of skin aging

March 2017

DEJ

Epidermis

Dermis

DEJ : DERMAL-‐EPIDERMAL JUNCTION

Collagens IV and VII: markers of elasDcity and firmness

Laminin 5: contribuDon to resistance of the DEJ ➡ epidermal cohesion and integrity

Perlecan: anchorage factor, stabilizes the DEJ ➡ skin firmness and density

REVERSKIN®SCIENTIFIC PROCESS

March 2017

Control reconstructed skin (with 50 years old fibroblasts)

REVERSKIN® (0,2%) reconstructed skin (with 50 years old fibroblasts)

Young reconstructed skin (with 20 years old fibroblasts)

27 µm73 µm 62 µm

REVERSKIN® increases the epidermal thickness

of reconstructed skin model with old

fibroblasts, comparable to skin equivalents

made with young fibroblasts (*p<0.05;

**p<0.01)

x2.3

***

Epidermis thickness (µm)

REVERSKIN® : test on 3D reconstructed skin

D35

March 2017

REVERSKIN®Control

D35

REVERSKIN® significantly increases basal kera0nocyte self-‐renewal responsible for the epidermal thickness

x3.3

Ki67 positive cells***

REVERSKIN® significantly increases cell prolifera&on

marker, Ki67, by 3.3 &mes, demonstra&ng pro-‐

regenera&ve proper&es (***p<0.001)


March 2017

REVERSKIN® improves skin elas0city and firmness

REVERSKIN® increases fibrillin expression, a

glycoprotein, essen&al for the forma&on of elas&c

fibers (p<0.05)

REVERSKIN®Control

D35

Fibrillin positive area

+25%


March 2017

x 2.5 (p<0.05)

x 1.5 (p<0.05)

Control ControlREVERSKIN® REVERSKIN®

D28 D56

Measurement of hydra0on using Corneometer®

REVERSKIN® significantly increases skin hydra&on compared to placebo

REVERSKIN® : test on volunteers

March 2017

REVERSKIN® 2% increases skin isotropy demonstra&ng an an&-‐aging/

restructuring effect (n=30 volunteers)

Measurement of isotropy (evalua0on of surface wrinkles) parameter (3D PRIMOS® Lite)


March 2017

Measurement of firmness-‐ R0 parameter (Cutometer®)

REVERSKIN® improves the

biomechanical parameters of the

skin, skin firmness and refines

skin texture


(*p<0.05) (**p=0.08)

March 2017

At D28, wrinkles are visibly smoothed

REVERSKIN® D28Control D0

Visible an0-‐wrinkle effect


Volunteer 16

March 2017

GLOBAL PHOTOPROTECTOR

March 2017

‣ From Buddleja officinalis flowers ‣ Tree from area of the sacred mountains in Sichuan province (in China)

‣Highly concentrated in VERBASCOSIDE and ECHINACOSIDE (2 photoprotective shields, powerful natural active ingredients)

SOLIBERINE®

Echinacoside ≈ 3% (DM*)

*Dry Matter

Verbascoside ≈ 15%

March 2017

SOLIBERINE® as a global photoprotector

SOLIBERINE®‣A powerful skin defense system, which maintains skin’s YOUTH, QUALITY and RADIANCE.

‣SOLIBERINE® prevents from dark spots, redness and premature wrinkles.

March 2017

In vitro 2D Models

NHEK or NHDF

In vitro 3D Models and explants

In vivo Clinical study

In tubo Chemical assays

Antioxidant Colorimetric assay FRAP & DPPH

Anti-‐inflammation Enzymatic assay 5-‐LOX and COX-‐2

Lipid peroxidation + UVB on liposomal fraction

TBARS

Free Radicals on NHEK + Blue Light (HEV)

Urocanic Acid on tape strips from Stratum corneum + UV(A+C) MMP-‐1 on NHDF + IR

On 30 volunteers + 4 UV(A+B) from 290 to 400 nm exposures for 21 days versus Placebo

▪ Parameter a* (measurement of erythema)

▪ Calculation of ITA°(measurement of skin pigmentation)

On 3D reconstructed full-‐thickness model + UVB

▪ Apoptotic cells (TUNEL) ▪ Sunburns cells (Melan-‐A) ▪ Melanin

▪MMP-‐1

▪ Elastin

Dermal absorption on ex vivo Human skin

SOLIBERINE®

March 2017

On Keratinocytes irradiated with blue light (HEV). ROS measurement

after irradiation.

‣ SOLIBERINE® significantly reduces ROS production induced by blue light ‣ SOLIBERINE® protects from oxidative damages induced by blue light

Control (no blue light)

UntreatedSOLIBERINE®

0.1%SOLIBERINE®

0.01%SOLIBERINE®

0.03%

-‐43%-‐42%-‐37%

ROS prod

uction

(RFU

, Relative Fuorescence Units)

+ Blue light (7 mW/cm2, 20 min), λ = 420 nm

******* ****

***p<0.001 ****p<0.0001

Protection against free radicals after Blue Light exposure

SOLIBERINE® : test In vitro

March 2017

On Fibroblasts irradiated with IR. Measurement of MMP-‐1 release by ELISA (colorimetric assay).

‣ SOLIBERINE® reduces by 22% infrared-‐induced MMP-‐1 release ‣ SOLIBERINE® preserves extracellular matrix and prevents its premature degradation induced by IR

Control (no IR)

+ INFRARED (0.66 kJ/cm2) 1h + quantification at 48h

Untreated Dexamethasone (+ control, 10-‐7 M)

SOLIBERINE® 0.1%

-‐22%

MMP-‐1 release (pg/ml) *

*p<0.05

Protection against ECM degradation after Infrared exposure


March 2017

‣ SOLIBERINE® stimulates Elastin production in normal condition and under UV exposure ‣ SOLIBERINE® preserves extracellular matrix

SOLIBERINE® 0.1% + UVB

Control + UVB (200 mJ/cm2)

On 3D reconstructed full-‐thickness model irradiated with UVB. Elastin quantification by fluorescence after 24h.

*p<0.05 ***p<0.001

+ UVB

Stimulation of Elastin production


March 2017

Volunteer n°01

Untreated area

Placebo area

SOLIBERINE® 2%

Without UV + UV

D11 (24h after the last irradiation at 1.2 MED)

D21

Without UV + UV

Visible protective effect against UV-‐induced erythema

SOLIBERINE® : test In vivo

March 2017

Zoom on the masks phenomenon« Masks make the buzz by mul&plying their offer and their effec&veness care »

Advantages :

-‐ Efficient thanks to a big quanDty of acDves

-‐ PracDcal and fast acDng

-‐ Typically feminine but also ideal for men

-‐ Creamy textures, allowing to offer a "cocooning" and comforDng treatment

Efficient, prac&cal and comfortable

This trend is in keeping with the dream of a perfect skin obtained in a night or in few minutes.

March 2017





‣Hair care products TILICINE®, INCA INCHI Oil Zoom on « low poo » products


Hair care products

March 2017

Hair care products

‣ In 2016, global haircare arket esDmated around USD 83,1 billion → Expected to grow to reach 94,5 billion in 2021

‣Health, baldness, hair loss and grey hair = major preoccupaDons

‣HairceuDcals very popular

March 2017

Cryoextract of Linden buds

CryoextracDon

Patented process

TILICINE®

March 2017

CRYOEXTRACTION

ADVANTAGES ‣ Preserva0on of the integrity of the ac0ves principles (enzymes, vitamins and polyphenols) ‣ Preserva0on of colour, odour, and biological integrity ‣ The ac0ve molecules content is higher than the one obtained from dried plants

Patented cryogenic process

March 2017

Hair volume + An0-‐sta0c

TILICINE®

March 2017

Coa0ng + Smoothing EFFECT

TILICINE®

March 2017

Shampoo & condi=oner -‐ Extra volume, Revitalizing, Enhancing

body Gently condi=ons

TILICINE® in the market

Mist for fine and normal hair -‐ Volumizing, Gives body

March 2017

Mascara -‐ Volumizing, Thicker effect, Longer eyelashes

TILICINE® in the market

INCA INCHI :

An example of sustainable

development with La&n America

January 2017

‣ Pressed from Amazonia plant known by local people for thousands of years; Incas civilizaDon already consumed it.

‣ The richest oil in unsaturated fa[y acids: up to 94% of total content

‣ The richest oil in Omega 3 (compared with oils of all oleaginous seeds)

INCA INCHI Oil

January 2017

REPAIRING effect on hair

INCA INCHI Oil

March 2017

Complete range of hair care -‐ Hair

repair

INCA INCHI Oil in the market

Precious oil for face, body and hair -‐

Nutri=on, Embellishment

March 2017

Zoom on the « low poo products »

‣ IniDally, ritual used by women with curly and frizzy hair to give a fresh blow to their mane : applicaDon of condiDoner and a good rinse ‣ Widely used in the summer acer the beach to feed without drying more

‣ Today, many brands offer a new generaDon of products that they call "low poo" or "co-‐washing" for washing condiDoner : these neo-‐shampoos contain few surfactants and many care agents.

What is the « low poo trend »?

✓without s

ilicones

✓without p

arabens

✓without s

ulphates

✓without m

ineral or

essenDal o

ils

March 2017






‣Personaliza&on and ethnical beauty

Personaliza0on and ethnical beauty

March 2017

Personaliza0on and ethnic beauty

‣ Desire for more individuality and personalized products

‣Beauty code more natural and diverse

‣Each skin and hair type -‐> its own characterisDc and needs

March 2017

Example : adapted complexes

‣ Complex blond hair (German camomile)

‣Complex brown hair (Walnut tree)

‣Complex red-‐brown hair (Henna)

www.greentech.fr [email protected]

Thank you !

greentech(presenta0on€¦ · may 2015. march)2017 phytosterols ecdysone (12%) mw 464.63 g/mol logp...

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