Ingredient Applications: Nutritional Supplements | Foods & Beverages | Cosmetics | Pharmaceutical

Graminex L.L.C. ®

GRAMINEX at a glance

• Established in 1997• NSF cGMP certified since 2003• Manufacturing and R&D located in

Deshler, OH, surrounded by nearly 6,500 acres of corporate farmland.

• World’s exclusive grower, harvester and producer of non-solvent extracted, standardized, flower pollen.

• Worldwide distribution: North America, Mexico, South America, Europe, Russia, Asia

• Vertical integration means: QUALITY, CONSISTENCY, EFFICACY

GRAMINEX: Capacity• Corporate Office:

Saginaw, MI

• Manufacturing/R&D:

Deshler, OH

• Farm Land:6,500+ acres / 2,630 hectares

• Plant Facility: 75,025 ft2/ 6,970 m2

• Warehouse: 285,000 ft3/ 8,070 m3

• Silos: 365,000 ft3/ 10,335 m3

Manufacturing Process

Flower Pollen Extract Quick Facts• Graminex Flower Pollen is NOT BEE POLLEN

– Graminex Flower Pollen Extract is a mechanically harvested, highly controlled, extracted and is a standardized ingredient.

– Graminex Flower Pollen Extract is NON-ALLERGENIC (oral and dermal safety studies available)

– Contains no heavy metals or environmental contaminants– Is highly bio-available– Over 100 Clinical Studies conducted supporting safety and efficacy

• KOSHER Approved• Free from: Solvent Residue | Pesticides | Allergens | Aflatoxins | Lactose |

Gluten | Talc | Salt | Sugar | Yeast | Wheat | Soy | Starch | Dairy

A flower pollen granule has an outer crust which protects the nutrient material contained inside the pollen. The allergic portion on the outer crust contains: Hair Fungus Yeasts Molds

Each pollen grain has a micro-hole, that when ruptured, allows for the separation of the allergenic outer crust and the essential internal nutrients. This leaves the nourishing substances found in the internal grain readily available to the body for absorption.

Graminex® uses a special manufacturing process to rupture the micro-hole through a non-solvent extraction process. The ruptured pollen grains are then centrifuged to separate the nutritional components from the allergens.

The flower pollen nutrients are concentrated to exact nutritional specifications by Graminex®. The remaining components are recycled and used for various industrial applications.

Benign Prostatic Hyperplasia (BPH)

• Disorder in which central core of prostate over-grows

• Parts surrounding urethra become water-logged and swollen

• Creates pressure on the urinary passage making it more difficult to function properly

• Two types of symptoms are related: obstructive and irratative

Obstructive Symptoms• Hesitancy• Poor Stream• Interruption• Incomplete emptying of the bladder• Needing to strain• Terminal Dribbling

Irritative Symptoms• Nocturia• Urgency• Pain when urinating• Increased frequency of urination

Assessment of Symptoms• Physical Examination• Diagnostic Testing• Symptom Index Evaluation

Incidence of BPH in Men by Age

40 45 50 55 60 65 70 75 800

10

20

30

40

50

60

70

80

90

100

Age in Years

Pe

rce

nt

of

Me

n

Treatment Therapy Options• Watchful Waiting• Prescription Drugs

– Flomax, Proscar, Hytrin

• Phytotherapies– Flower Pollen, Pumpkin Seed, Saw Palmetto

• Surgical Procedures– Transurethral Resection of the Prostate (TURP),

Transurethral Incision of the Prostate (TUIP), and Open Prostatectomy

• Minimally Invasive Techniques– Laser Prostatectomy, Transurethral Thermotherapy, High Instensity Focused

Ultrasound, Transurethral Needle Ablation (TUNA), Prostastic Stents, Transurethral Electrovaporization.

• Testosterone Replacement– Increases the development of prostate cancer– Increases the development of cardiovascular disease– Only 2% of the men over the age of 50 have reduced testosterone levels

U.S. Market Size for Prescription Drug Treatments for BPH

2000 2001 2002 2003 2004 2005 20060

2000

4000

6000

8000

10000

12000

14000

Year

Drug

Rev

enue

s , $

Mill

ions

World Market Size for Prescription Drug Treatments for BPH

2000 2001 2002 2003 2004 2005 20060

2000

4000

6000

8000

10000

12000

Other Japan Europe US

Year

Dru

g R

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ues

, $

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Treatment Preferences

Mild Moderate Severe0

10

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30

40

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60

70

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Treatment Choices of BPH Patients

Watchful Waiting Drug Therapy Surgery

Symptoms

Perc

ent o

f Res

pond

ents

Prostate: Clinical Benefits of Flower Pollen

Shrinkage of the prostate after treatment with Flower

Pollen

• Anti-inflammatory to reduce the size of the prostate gland

• Anti-oxidative effects to reduce free radicals

• Immune system stimulation

• Effective for chronic, non-bacterial prostatitis

Graminex Flower Pollen Extracts• Graminex

G63™ Flower Pollen Extract inhibits the arachidonic acid cascade to prevent intraprostatic tissue edema and fibrosis.

Graminex Flower Pollen Extract• Contains health promoting nutrients including:

- Vitamins- Amino acids- Nucleic acids- Minerals

- Long chain alcohols- Unsaturated fatty acids, - Prostaglandin precursors - Plant hormones

• Applications include: - Pharmaceutical- Nutraceutical- Cosmeceutical

- Functional food- Functional beverage- Pet food and supplement industries

• Indications and uses include: - Anti-inflammatory- Immune system booster- Accelerate wound healing

- Improves osteoarthritis symptoms- Improves tiredness- Improves prostatitis symptoms

G63 Flower Pollen Extract• Used in the Pharmaceutical,

Nutraceutical, Functional Food and Beverage Industries

• Scientifically substantiated to support normal prostate function and urinary flow.

• High degree of efficacy and safety, established by use and substantiated by science in over 100 clinical references for 12 indications.

• Standardized full spectrum formula• Developed for turn-key production;

easily flows in capsules or pressed into tablets

• Therapeutical claims are currently approved by the authorities in various countries.

G60 / G60WS Flower Pollen Extract• Water soluble portion of Flower

Pollen Extract• Standardized for Amino Acids; not

less than 6%• Fully water soluble provides high

degree of usability for nutritional supplements, functional foods, beverages and cosmetic applications

• Clinically supported for safety and efficacy

• Contains a complete amino acid profile, high level of antioxidants.

NAX 7% Paste• Lipid soluble portion of Flower

Pollen Extract• Standardized for Phytosterols, not

less than 7%• Available nutrients include

phytosterols, isoflavones, enzymes and antioxidants.

• Applications include women’s health, skin health and heart health.

GraminexG63

GraminexG60

GraminexNAX 7%

Bee Pollen Saw Palmetto

Full Spectrum of Active Ingredients

Standardized

Solvent Free

Clinically Backed

Water Soluble

Lipid Soluble

World-Wide Registrations

Drug Master File

Bio-Available

Non-Allergenic

Oxygen Radical Absorption Capacity:a measure of antioxidant value

The antioxidant activity found in foods, minerals, and plants is found by performing an Oxygen Radical Absorbance Capacity Test, which gives you the ORAC value of a substance. The substances are then given a “score” to rank how well it can neutralize or destroy free radicals. All values are shown in (umole TE / g) as reported by the FDA.

Oxygen Radical Absorption Capacity:a measure of antioxidant value

0

50

100

150

200

250

300

5 11 14 21 24 26 27 32 39 51

102105

146164

288

ORA

C V

alue

ORAC Values Fruit vs. Graminex Flower Pollen Extracts

0

50

100

150

200

250

300

3 3 5 10 12 1224

37 39 42

102

146

288

ORA

C V

alue

ORAC ValuesVegetables vs. Graminex Flower Pollen Extracts

* These charts compare various foods and supplements to Graminex Flower Pollen Extract™, based on their values as reported by the US FDA.

Additional Studies upon request.

Recommended Daily Dosage: 500 – 1500mg

Products and ServicesIngredients:

Standardized Flower Pollen Extracts

Blending

Private Labeling

Over 100 Clinical Studies on the following indications:

Prostate Health | Urinary Function | Anti-Inflammatory Effect |

Liver Health | Seasonal Allergies | Menopausal Health |

General Health and Nutritional Support | Diabetes |

Malnutrition | Fertility | Immune System Support

Ingredient Applications:

Nutritional Supplement | Functional Foods &

Beverages | Pharmaceutical | Cosmetics

2010 Graminex LLC

Flower Pollen ExtractMade in USA

www.GRAMINEX.com