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Graduate School of ExcellenceGraduate School of Excellence

PhD Program “Molecular Medicine“

Hannover Medical School Hannover Biomedical Research School

Report 2010

PhD Program “Molecular Medicine“

Hannover Medical School Hannover Biomedical Research School (HBRS)

Responsible Univ. Prof. Dr. Reinhold E. Schmidt Chairman PhD Program Carl-Neuberg Str. 1 30625 Hannover Tel: 0511-532-6656 [email protected] PhD committee:

Prof. Dr. A. Gossler, Prof. Dr. G. Behrens, Prof. Dr. C. Klein, Prof. Dr. M. Gaestel, Prof. Dr. D. Manstein, Prof. Dr. B. Schlegelberger, PD Dr. A. Braun, N. Heinz, S. Müller, A. Kühl, A. Kühr Dr. Susanne Kruse, Marlies Daniel PhD Office

OE 9117 Carl-Neuberg Str. 1 30625 Hannover Tel. 0511-532-6011 [email protected] [email protected] Internet: www.mh-hannover.de/hbrs.html

Chairman of the PhD program

The PhD program “Molecular Medicine“ (former MD/PhD program) was established in autumn 2000. Our program has meanwhile become one of the leading PhD programs in Germany due to excellent interdisciplinary cooperation between the Hannover Medical School (MHH), the Leibniz University Hannover, the School of Veterinary Medicine Hannover, the Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), the Technical University Braunschweig and the Helmholtz Center for Infection Research (HZI), Braunschweig, due to the former support of the International Promotion Program (IPP) by DAAD and DFG. We are also proud to have international outstanding teachers, such as Prof. Fritz Melchers (Immunology; MPI Berlin), in our program. There is a good ratio between medical students and students from life sciences as well as between German and foreign students. This program attracts great national and international interest. Additionally, the PhD program is the basis for the Hannover Biomedical Research School (HBRS) founded in 2003, which is extremely successful in integrating all postgraduate programs at MHH. Joint curricula have been established.

We are very proud that the HBRS is funded since October 2006 with 5 Million Euro by the German Excellence Initiative (DFG) for five years. Meanwhile, more than hundred students have successfully graduated from the program. They are ambassadors for MHH around the world. Many sponsors are generously providing support for our workshop or stipends for our students. Many thanks to everyone who has supported this PhD program, especially to those students who determine the excellence of the program,

Reinhold E. Schmidt, MD Professor of Medicine and Immunology

Dean of Hannover Biomedical Research School

We express our thanks to our sponsors: DFG (Deutsche Forschungsgemeinschaft) Martin Lawrenz, Hannover

Table of Contents

I. Current Status, Problems and Prospects_________________________ 7

1. Current Status _____________________________________________________________________7 2. Common Rules___________________________________________________________________100 3. Cooperation with International Institutes_____________________________________________111 4. Success and measures for implementation _____________________________________________12

II. Measures and Results _______________________________________ 13

1. Personnel ________________________________________________________________________13 2. Language courses _________________________________________________________________14 3. Social Activities, Excursions and Final Exams __________________________________________14 4. Guest Lectures and additional colloquia_______________________________________________15 5. Travel ___________________________________________________________________________17

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I. Current Status, Problems and Prospects

1. Current Status

Statistics Applications 2010

Country Number of applicants (first preference)

Now in the program

Total female male Total female male

Germany 16 6 10 6 3 3

Western Europe: 9 4 5 1 - 1

Central and Eastern Europe

12 9 3 1 1 -

North America: 1 1 - - - -

Latin America: 2 1 1 - - -

Africa, Subsahara: 25 5 20 - - -

North Africa and Middle East:

61 23 38 4 2 2

Asia, Australia and Oceania:

293 105 188 8 5 3

Total: 419 154 265 20 11 9

Second preference: 285; Total number of all applicants for “Molecular Medicine”: 704 (for whole HBRS: 930)

Final exams in the PhD program 2010:

Sixteen students passed their final exams in June and November 2010. From 17 students of the year

2007, four did their final exams after exactly 3 years = 24%, six plan to finish after 3.5 years, seven

after 4 years.

Detailed Description At the moment (February 2011) there are 75 students in the program [42 females and 33 men; 48

international and 27 Germans; 16 medical students (incl. veterinary students) and 59 students from life

sciences]. The international students come from Austria (1), Belarus (2), Bulgaria (1), China (1),

Ethiopia (1), Greece (1), India (25), Italy (1), Iran (4), Indonesia (2), Jordan (1), Lebanon (1), Portugal

(1), Singapore (1), Taiwan (3), Venezuela (1) and Vietnam (1).

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Students are either financed by the corresponding departments or by scholarships (DAAD, DFG,

MHH, industry etc.). We are very happy that from 2007, HBRS provides a number of half stipends

(1.250,- or 1350,- Euro/month for 18 months) for the best ten students of the ranking list after selection

through funds of the German Excellence Initiative (DFG).

Concerning selection of the new students, a 3-step level procedure was introduced in 2002. It consists

of: 1. pre-selection by the PhD commission, 2. a written test in the individual home countries, 3. an

interview (in 2009 in Hannover, New Delhi and Chennai, India). For the period 2007/2008, HBRS has

introduced a new online application system, which worked successfully and was further improved for

the period 2008/2009 and 2009/2010.

The selection of the applicants is based on qualification only. The accepted candidates are supposed to

choose a department and a research project themselves. This means that there can be bottle-necks

regarding the guarantee of the financing of the students. For this reason scholarships were applied for

with e.g. the Excellence Initiative of the German government (see above).

In 2010, orientation weeks were organized from October 4th to 25th with the kind support by the

DAAD (STIBET) and Excellence Initiative.

Students work on a 3-year research project in one of the departments of the MHH or at cooperating

institutes (see list of students). In addition, there is an obligatory program of teaching consisting of

seminars and tutorials (see list of lecturers).

In October 2003, the Graduate School: “Hannover Biomedical Research School” (HBRS) was founded

at MHH (director: Prof. Dr. R.E. Schmidt, office: Dr. S. Kruse). Here, all graduate programs [PhD

(PhD “Molecular Medicine”, PhD “Infection Biology”, PhD “Regenerative Sciences”, Graduate

Colleges (GRK 1441 “Allergic response in lung and skin”, European GRK “Strategies of human

pathogens to establish acute and chronic infection”), etc.] are coordinated.

In 2004, a joint Curriculum of the HBRS [PhD program, PhD program “Infection Biology” (speaker:

Prof. Dr. Förster), PhD program “Regenerative Sciences” (speaker: Prof. Dr. Baum) and HRSIB (HZI,

Braunschweig, speaker: Prof. Dr. Hauser); and GRKs] was established in order to bundle resources. In

the first year, basics and methods of biology and medicine are taught. There are special in-depth

seminars for medical students as well as life scientists.

During the second academic year, focus lies more on current research projects (applied aspects). Since

2003, four main foci have been established in the PhD program: Immunology; Infection; Oncology

and Differentiation; Genetics and Cell Biology (Fig. 2).

Besides an extensive English curriculum, guest seminars, scientific colloquia, discussions with the

supervisors and technical practical courses took place.

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Most important are the so-called “soft skills“ as well as seminars about “Animal Experiments“,

“Scientific Writing“, “Presentation techniques”, “Intercultural communication”, “Stress Management”/

“Conflict Management”, “Bioinformatics”, “Translational research, Drug Development”, “Career

perspectives” etc. The students keep book about all seminars. The lecturers are regularly evaluated.

After 18 months, students give an oral intermediate exam in the respective main subject and the

subject of the co-examiner (presentation and discussion of a research paper). After 3 years the final

exam is given in form of a public disputation.

In 2010, sixteen PhD students (Arpita Baisantry, Gastroenterology/Hepatology/ Endocrinology,

India; Manoj B. Menon, Physiological Chemistry, India; Nidhi Narain, Gastroenterology/ TwinCore,

India; Amrita Rai, Biophysical Chemistry, India; Wilhelm Walter, Physiology, Germany;

Hengameh Abdollahpour, Pediatric Hemmatology and Oncology, Iran; Vijay Kumar Chennupati,

Immunology, India; Kshama Gupta, Molecular Hematopoesis, India; Niels Heinz, Experimental

Hematology, Germany; Sadaf Kasraie, Dermatology, Iran; Wolfgang Koestner, Pediatric

Hematology and Oncology, Germany; Jan Larmann, Anaestesiology, Germany; Harald Schütt,

Cardiology, Germany; Ratnesh Kumar Srivastav, Physiological Chemistry, India; Kristina Wiege,

Clinic for Immunology and Rheumatology, Germany; Xiangyue Zhang, Immunology, China)

successfully finished the program. Next final exams will be on June 17th and November 11th, 2011.

Figure 1. Structure of PhD Program “Molecular Medicine“

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3-year PhD project work (125 cp) Annual presentation in department (3x; 10 cp) Journal club (3x; 3 cp) Public annual presentation/project report (3x; 10 cp) Talk/presentation on international congress (2 cp)

Basics (seminar and tutorial; 3 h per week; 8 cp)

Year 1 Year 2 Year 3

Interdisciplinary seminars/courses (60 h; 6 cp) Project-orientated seminars/courses (80 h; 8 cp)

PHD thesis

and Final exam Complex and clinical

systems (seminar and tutorial; 3 h per week; 8 cp)

Intermediate Exam after 18 months

Figure 2. Curriculum 2009/10

In September 2002, a German-wide network of biomedically orientated PhD programs was

established, which was further enlarged by representatives of the DFG Graduate Schools of Excellence

working in the biomedical field in February 2008. In 2009, the sixth joint workshop on “Intercultural

communication” was organized by the PhD programs of Göttingen and Hannover in Germerode.

2. Common Rules

On 15.12.99, a rule for the PhD program was passed by the senate of Hannover Medical School. This

rule unites a regulations for studies and exams. On 12.02.02, the PhD program received authorization

from the Lower Saxony Ministry for Science and Culture to alternatively award besides the PhD title

for scientists the title Dr. rer. nat. Such changes in the rules and adaption to the program situation were

passed by the senate on 04.06.02. On 11.02.04, the rules were adapted to the suggestions by the

committee of referees for accreditation and were overall updated, same accounts for April 2005. On

March 14th, 2007, the PhD rules have been adapted for all programs in the HBRS. In addition, special

rules and regulations for HBRS were developed since then.

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For all: Seminar, 2h and Tutorial, 1h

1st year

In parallel: special in-depth seminars for medical students and students from life sciences, respectively

Basics in Molecular Medicine (Focus on Methods) Seminar, 2h

Tutorial, 1h

Tutorial for the respective seminar/tutorial series

1st sem. 2nd sem.

2nd year

1. Focus: Immunology

2. Focus: Genetics & Cell Biology

3. Focus: Infection

4. Focus: Differentiation & Oncology

or

or

4th sem. 3rd sem.

3rd year: concentration on individual research projects

Immunology/Stem Cell Biology/ Bacteriology/ Virology

Cell Biology/ Genetics/ Biochemistry/ Methods

3. Cooperation with International Institutes

Fortunately, within the MHH there is an active exchange, i.e. participation of almost all scientifically

active departments in the PhD program – whether by means of active organizing within the PhD

commission, by supervising the PhD students at the research laboratories or as lecturers in the

numerous educational programs. This goes for the basic scientific as well as for the clinically

orientated departments, for example: Biochemistry, Cardiology, Cell Biology, Clinical Immunology,

Dermatology, Gastroenterology-Hepatology-Endocrinology, Genetics, Hematology, Heart and

Thoracic Surgery, Immunology, Microbiology, Molecular Biology, Nephrology, Oncology, Pathology,

Physiology, Rheumatology, Tumor Biology, Virology, Visceral and Transplantation Surgery, etc.

Therefore intensive cooperation exists between collaborators (Post-docs etc.) from Graduate Colleges

with the PhD program. Moreover, the “Graduate School” (HBRS) was founded in October 2003.

There is close cooperation between the graduate and PhD programs of the School of Veterinary

Medicine Hannover, also concerning lecturers and students. In addition, there are very close

cooperations to the Helmholtz Center for Infection Biology (HZI) in Braunschweig and the Fraunhofer

Institute for Toxicology and Experimental Medicine (ITEM) in Hannover. Thanks to the scientists of

the MHH there is already intensive cooperation with European and internationally very well-known

research institutes (e.g. also by means of the two European Research Training Groups). Of course, the

PhD students profit from this cooperation, too.

A constant exchange and participation in education and research exists with the following institutes:

a) national and international:

• Helmholtz Center for Infection Research (HZI); Braunschweig • University of Veterinary Medicine, Hannover • Fraunhofer Institute for “Toxicology and Experimental Medicine” (ITEM), Hannover • Friedrich-Loeffler-Institute, Federal Institute for Animal Health (FLI), Mariensee (former FAL) • Max-Planck Institute for Immunobiology, Berlin

There is intensive cooperation with these national institutes concerning education (lecturers) as well as

concerning research, i.e. making three year projects available or the function of scientists as (co-)

supervisors.

b.) Economy/Industry (especially with):

Solvay GmbH Hannover, Schering AG Berlin and Novartis GmbH Basel

Industry excursions (e.g. Solvay AG, Bayer AG, Qiagen etc.) are regularly taking place.

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4. Success and measures for implementation

In 2010, sixteen students successfully finished the PhD program (see above). More than half of the

finalists continue to work at MHH or German universities (medical consultant, Postdoc etc.). Six of

them already plan or went to work as Postdocs abroad (USA, Austria, India, Switzerland), one is

working in a pharmaceutical company in Germany.

The PhD program has established an ALUMNI organization and student’s network. In 2010, the fifth

Alumni newsletter was created.

The PhD program plays a key role (scientific, organization) in Hannover Biomedical Research School

(HBRS).

In 2010, the 10th anniversary of the PhD program “Molecular Medicine” was celebrated on October

24th/25th. Alumni students and members of the international advisory board were invited. There was a

get-together, a scientific symposium as well as the celebration ceremony. An anniversary brochure of

HBRS was created.

In 2006, MHH was very successful in the German Excellence Initiative. HBRS (with its PhD program

„Molecular Medicine“) will be supported with 5 Million Euro for the next five years. This includes the

position of the scientific coordinator Dr. Kruse, 25 „half“ PhD stipends (18 months) per new year,

language teachers, student tutors, marketing, invitation of guest lecturers, soft skills, summer schools,

teaching aids, flexible funds, selection processes, travel of coordinators, support of student’s travel to

congresses, child care.

In 2009, HBRS was successful in raising money from the EU (EFRE – Strukturfonds), 300.000,- Euro

for three years. Support is given mainly for career measures: workshops, soft skill courses, travel to

congresses.

The program was very successful in gaining sponsors, either for the annual workshop, the year book or

for student’s grants (see list on page 5). A sponsoring concept as well as special flyers were developed.

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II. Measures and Results The PhD Program “Molecular Medicine“ started in winter semester 2000/01. From 2002 to 2006, the

program was supported by the DAAD/DFG by means of the “International Promotion Program” (IPP).

From 2007, the program is supported by means of the “German Excellence Initiative” (DFG) for the

Hannover Biomedical Research School (HBRS).

1. Personnel

Within the Excellence Initiative, the posts for a scientific coordinator (full time), funds for assistant

students (see “non scientific care”; 10 hours/week) and language teacher have been granted.

In addition, there are 25 (half) stipends per year for PhD students available. They are given to the best

students in the selection procedures of the PhD program “Molecular Medicine” and PhD program

“Infection Biology”.

1.1. Scientific collaborators and administrative personnel

Since 01.05.2002, Dr. Susanne Kruse has been working on the program as scientific coordinator. She

has various tasks; she is responsible for the total coordination and organization of the PhD program

and HBRS, e.g.

• Consultation of the PhD students and applicants

• Organization and coordination of the application and selection procedure

• Cooperation with the PhD commission and HBRS

• Processing of the PhD commission meetings

• Contact to supervisors and lecturers of the Medical School and cooperating institutes

• Public relations (articles, homepage design etc.)

• Marketing (flyers, poster, advertisements etc.)

• Fund raising (incl. sponsors); applications (DFG, BMBF etc.)

• Planning and coordination of the curriculum (including “Soft skills”)

• Organization of workshops/seminars

• Evaluation of seminars and tutorials

• Preparation of exams and coordination

• Organization of the inauguration, non scientific care and social activities

• Contact to DFG and other PhD programs (esp. PhD Network)

• Administration of the budget

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Mrs. Marlies Daniel works at the PhD Office (full time) as person in charge/correspondent. Her

position is financed by the Hannover Medical School.

Mrs. Daniel supports Dr. Kruse with the coordination und organization of the PhD program. She is

responsible for the total correspondence, telephone calls, organization of the application procedure,

organization of events, taking care of the students (esp. during the training period: organization of

accommodation, banks, insurance etc.), statistics etc.

1.2. Tutors

In 2010 six undergraduate students have been employed as assistant student on an hourly basis. They

especially take care of the PhD students in close cooperation with the “International Office”, help at

German authorities, support International evenings, exams and other celebration ceremonies.

2. Language courses

Mrs. Petra Marotz has been employed as the German teacher since 01.10.2002 (hourly basis). In

October 2008, Mrs Gesine Mann was hired. Both teach 2 hours/week; plus an intensive German course

during the orientation weeks. This concerns a course for beginners and an advanced course (1 year

experience). A total of over 20 PhD students of HBRS participate in the courses.

Mrs Lydia Lange is employed as teacher for Scientific English, also 2 hours/week.

3. Social Activities, Excursions and Final Exams

• On 04.02.10 students visited the opera house in Hannover („My Fair Lady“), in cooperation with

the International Office.

• On 11.06.10, final exams of five PhD students took place.

• Orientation weeks (04.10.-25.10.10) were organized for all three PhD programs in the HBRS.

• The opening of term / welcome of new students was celebrated also on 25.10.10. All students,

supervisors and lecturers of the PhD program “Molecular Medicine“, the PhD program “Infection

Biology”, the PhD program “Regenerative Sciences”, the Master programs “Biomedicine” and

“Biochemistry” as well as the president of MHH and several guests participated. Invited speaker

for the “Fritz-Hartmann Lecture” was Prof. Dr. Fritz Melchers (Max-Planck Institute Berlin; see

also 4.), musical introduction by: Uta Fricke + Band.

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• On 19.11.10, final exams of eleven PhD students and festive ceremony after the final exams took

place. Invited guest speaker was Prof. Dr. Fred Schaper (Magdeburg, Germany); see also 4.),

musical introduction by Katja Zakotnik (Cello).

• On 20.11.10, an international Party (Indian Diwali Festival) was celebrated with all students,

supervisors and lecturers of HBRS (all programs) and guests.

• On 09.12.10 students visited the opera house in Hannover („Guys and Dolls“), in cooperation with

the International Office.

• On 17.12.10, HBRS invited everybody to a Christmas party

4. Guest Lectures and additional colloquia

• From 12.01.-13.01.10, a workshop on „stress management“ was given by the trainer Grit Kümmele

(Berlin).

• On 22.01.10, Dr. Kruse held the seminar “Scientific writing“ at MHH.

• On 31.01./31.01. and on 12.02./13.02., the advance course Scientific writing was given by John

Chandler

• On 19.02.10, the first HBRS Career Day was organized. Lecturers and companies from different

professional fields were invited.

• From 04.-05.03.10, the annual Stephansstft Workshop (retreat) was taking place. Students had to

present and discuss their projects with all participants (students, supervisors, lecturers). In addition

assemblies of students as well as lecturers/supervisors were organized. The international evening

was planned for Friday. The workshop was financially supported by a number of sponsors.

• From 08.03.-12.03.10 and from 13.-17.12.10, Prof. Hedrich and colleagues held the course “Basics

in Laboratory Animal Sciences“ for HBRS students at MHH.

• From 13.04.-14.04.10 Dr. Mertsching and colleagues organized the course “Genetechnology

Safety“ only for HBRS students at MHH (in German) (the English course takes place in

September, also for other participants).

• On 16.04./17.04.10, the “Assessment center” course was given

• On 23.04.10, the “Time Management” course took place

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• On 03.-06.05.10 (in Braunschweig), Bioinformatics courses were organized in cooperation with

the TU Braunschweig (Prof. Schomburg)

• On 04.05.10 the written test for new applicants was given at MHH. In addition, tests were

organized in home countries of candidates.

• On 07.05.10. the “Team Work” Workshop took place

• From 04.-06.06.10, the workshop “Intercultural Communication“ took place in Frille in a joint

effort of PhD programs in Göttingen and Hannover.

• On 09.06.10, five PhD students had their final exams (public defences; in English). At least one

external examiner was invited (Daumke, Berlin; Diez, Dresden; Dobbelstein, Göttingen; König,

Göttingen; Niemann, Mariensee). The official festive act was celebrated on 19.11.10 (see below).

During their stay in Hannover, some of the external reviewers gave guest lectures talking about

their own research results.

• Altogether 73 applicants were invited for interview in Hannover, Teheran (Iran), New Delhi (India;

DAAD office), Chennai (India; DAAD office) in June/ July 2010. Candidates had to give short

presentations of previous experimental work and were asked questions (total 20 min).

• On 08./09.07.10, the workshop “Job hunting in the academic world” was organized (trainer:

Thomas Obieglo, Berlin)

• From 16.08.-20.08.10 the practical course “Functional Genomics” was organized by the group of

Dr. Franzke

• From 12.-16.09.10, the second HBRS Summer School on “Gene regulation, cell differentiation and

tolerance” in “Hessenkopf” Goslar was organized. About 15 outstanding invited speakers as well

as 50 students participated. Guest students from other German universities were invited.

• On 24.10.10, Alumni students and guests talked about “Career perspectives” in course of the get-

together for the 10th anniversary ceremony

• On 25.10.10, the HBRS symposium and the opening of the new study year was celebrated. Guest

speaker was Prof. Dr. Fritz Melchers (Max-Planck Institute, Berlin).

• On 08.11.10, Prof. Melchers gave lecture in course of the HBRS curriculum.

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• On 19.11.10, the final exams (public defence; in English) were organized for eleven PhD students.

At least one external examiner was invited (Hauser, Braunschweig; Mittrücker (2x), Hamburg;

Radeke, Frankfurt; Rosenberger, Frankfurt; Schaper, Magdeburg; Schmid-Grendelmeier, Zürich;

Schmitz, Giessen; Sperandio, Munich; Stocking-Harbers, Hamburg; Uckert, Berlin). On the

evening of the festive ceremony, Prof. Dr. Fred Schaper (Magdeburg) was invited as guest speaker.

Musical introduction was given by Katja Zakotnik. During their stay in Hannover, some of the

external reviewers gave guest lectures talking about their own research results.

• On 07.-08.12.10, a workshop on „Conflict management“ was given by the trainer Grit Kümmele,

Berlin.

5. Travel

• On 28.04.10, Dr. Kruse was invited to give a talk at the medical faculty of Tübingen (Tag der

Lehre).

• From 19.06.-24.06.10, Prof. Dr. Georg Behrens, Dr. Kruse, Prof. Dr. Tim Sparwasser performed

interviews with 49 Indian/ South Asian applicants for HBRS programs in the DAAD office in

Chennai. And ICGEB in Delhi.

• On 05.07.10, Dr. Kruse gave a talk in Düsseldorf in course of an “Orpheus” meeting.

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year 2005

Amrita Rai

Ratnesh K. Srivastav

Education

College/University:1999-2002 Banaras Hindu University, B.Sc. (Hons) in Chemistry2002-2004 Indian Institute of Technology Roorkee, Roorkee M.Sc. in Biotechnology.

Highest degree:M.Sc.

Major Subjects:Biotechnology

Projects/Research:1. Structure and function of Dynamin and Dynamin Related Proteins.2. Worked as J.R.F at National Centre for Cell Science,Pune India. I was working on project “ Differentiation of mouse embryonic stem cells (mES) into Pancreatic ß cell like clusters (2004-05)3. Project work on “ Studies on acid and salt tolerance of Rhizobial strains isolated from legumes(2004)4. Worked on cloning ,expression and characterization of phosphoenol pyruvate carboxylase,UV survival and thermoluminescence of wild and mutants of Anacystis nidulans (2003).

Scholarships:1. Junior Research Fellowship (JRF) awarded by Council for Scientific and Industrial Research (CSIR), India. Among top 20%2. Qualified Graduate Aptitude Test in Engineering (GATE). All India Rank 563. Received Biotechnology Scholarship for Masters (2002-04),it was sponsored by DBT ,India.

Scientific Interests and Goals:To learn more about Dynamins.

Hobbies and other interests:Music , Dress designing and Roaming

First name:Amrita

Last name:Rai

Date of birth:15-07-1980

Country:India

E-mail:[email protected]

Supervisor:Prof. D.J.MansteinBiophysical Chemistry

EducationCollege/University:2001-2003 Madurai kamaraj University M.Sc in Biotechnology.

Highest degree:M.Sc. in Biotechnology


Projects/Research:1.Expression, refolding and purification of ßketo acyl ACP reductase an indespansible enzyme of Fatty acid biosynthesisof plasmodium.2.Cloning, subcloning and expression of PKS antibiotics in E.coliexpression system.3. Refolding and purification of C and Z sigma factor of Micobacterium tuberculosis.

Scholarships:1. Awarded by DBT,india for selection in All india combinedM.Sc. biotechnology programe (2001-2003).2. Junior Research Fellowship (JRF) awarded by Council forScientific and Industrial Research (CSIR), India.3. R&D Assistantship from JNCASR, Bangalore, India.4. 40th rank in GATE coducted by Indian institute of technology India in 2003.

Scientific Interests and Goals:My main field of interest is Biochemistry.

Hobbies and other interests:Music, Cricket, Movies, literature, etc.

First name:Ratnesh

Middle nameKumar

Last name:Srivastav

Date of birth:11.10.1979

Country:India


Supervisor:Dr. R. Niedenthal/ Prof. Dr. M. GaestelPhysiological Chemistry

year 2006

Hengameh Adollahpour

Nora Anderson

Arpita Baisantry

Hari Balaji

Kshama Gupta

Niels Heinz

Wolfgang Koestner

Manoj Menon

Nidhi Narain

Daniel Poehnert

Wilhelm Walter

Kristina Wiege

Xiangyue Zhang

EducationCollege/University:1997-2005 Tehran University of Medical Sciences, school of Medicine2005-2006 Department of Experimental Pediatrics Hematologyand Oncology, Medical school of Hanover

Highest degree:Medical Doctor (MD)

Major Subjects:Medicine, Molecular Medicine and Cancer biology

Projects/Research1- To study different functions of transcription repression factorGfi1 in Hematopoieitic system2- Identification of new genes and mechansims, involved in severe congenital neutropenia

Award and Scholarship:1- First rank award of provincial pre-university college, Iran 19972- Ranked 16th in the University Entrance Exam held by the Ministry of Science, Research and Technology in Iran. 3- Graduated from medical school with GPA: A+

Scientific Interests and Goals:My aim is to identify new genes which are involved in congenitalneutropenia and therefore understanding the mechanisms of myeloid system development comprehensively.

Hobbies and other interests:Music, travelling, Movies, literature, etc.

Publications:Necrosis of nasal cartilage due to mucoromycosis in a patient with severecongenital neutropenia due to HAX1 deficiency.Fahimzad A, Chavoshzadeh Z, Abdollahpour H, Klein C, Rezaei N.J Investig Allergol Clin Immunol.2008;18(6):469-72

Novel HAX1 mutations in patients with severe congenital neutropenia revealisoform dependent genotype-phenotype associations.Germeshausen M, Grudzien M, Zeidler C, Abdollahpour H, Yetgin S, RezaeiN, Ballmaier M, Grimbacher B, Welte K, Klein C.Blood.2008 May 15;111(10):4954-7

A servey of pediatricians‘ knowledge on asthma management in childrenGharagozlou M, Abdollahpour H, Moinfar Z, Bemanian MH, Sedaghat MIran J Allergy Asthma Immunol 2008 Jun:7(2):85-90

First name:Hengameh

Last name:Abdollahpour


Country:Iran


Supervisor:Prof. Dr. Christoph KleinPediatrics HematologyOncology

EducationCollege/University:1998-2005 Hannover Medical School (MHH), Germany2003-2003 Doctoral student, Department of Anesthesiology,

University of Colorado: Health Sciences Center, Denver, CO, USA.

Highest degree:Dr.med.

Major Subjects:Medicine

Projects/Research:NMR- and MS-based metabonomic approaches to assess biomarkers of liver toxicity.

Scientific Interests and Goals:My specific focus of interest is the connection between aberrations of the cellular metabolism and pathological conditions, including the metabolic response to toxic injury andits role in malignant transformation and maintenance of the malignant phenotype. By working in the research field of metabonomics I hope I will be able to contribute to translation of basic research into advantages for clinical practice.

Hobbies and other interests:Hiking, Literature, Music, Movies

Publications:Klawitter, J. Anderson, N., Klawitter, J., Christians, U., Leibfritz, D. Eckhardt, S. G., Serkova, N.J. Time-Dependent Effects of Imatinib in Human LeukemiaCells: A Kinetic NMR-Profiling Study. British Journal of Cancer [accepted for publication in January 2009].Anderson, N. and Borlak, J., Molecular concepts in steatosis and steatohepatitis, Pharmacological Reviews 2008; 60:311Anderson, N. and Borlak, J., [Book chapter:] Mechanisms in Hepatotoxicity. In: Hepatotoxicity - From Genomics to In Vitro and In Vivo Models, edited bySaura Sahu, John Wiley & Sons, First Edition (2008).Anderson, N. and Borlak, J. Drug-induced phospholipidosis, FEBS Letters 2006; 580(23):5533. Gottschalk, S., Anderson, N., Hainz, C., Eckhardt, S.G.,Serkova, N. Imatinib(STI571) – mediated changes in glucose metabolism in human leukemia BCR-ABL-positive cells. Clinical Cancer Research 2004; 10: 6661-6668

First name:Nora

Last name:Anderson


Country:Germany

E-mail:Nora.andersonweb.de

Supervisor:Prof. Dr. J. BorlakMolecular ToxicologyFraunhofer Institute, ITEM

EducationCollege/University:2001-2004 : B.Sc. (Hons) Microbiolgy, Gargi College, Delhi University,

New Delhi, India.2004-2006 : M.Sc. Biotechnology, AIIMS, New Delhi, India.

Highest degree:M.Sc. in Biotechnology.

Major Subjects:Biotechnology, Molecular Biology, Immunology, Cell Biology

Projects/Research:Functional consequence of tinf2 haploinsufficiency in organismal aging

Awards and Scholarships:1. Junior Research Fellowship (JRF) awarded by Council for Scientific

and Industrial Research (CSIR), 2006, India. 2. Junior Research Fellowship (JRF) awarded by Department of

Biotechnology (DBT-JRF),2006, India.3. Junior Research Fellowship (JRF) awarded by Indian Council of

Medical Research, 2006, India.4. Secured University 2nd rank in B.Sc. (Hons) Microbiolgy (2001-

2004), Delhi University.5. Award for Best Student securing highest aggregate in South Campus

(2001-2004), Delhi University.

Scientific Interests and Goals:Telomere shortening likely influences human ageing by limiting stem cell function, regenerative reserve and organ homeostasis. The checkpoints that are induced by telomere dysfunction on stem cell level are unknown. The characterization of such checkpoints could help to define therapeutic targets aiming to improve regenerative reserve and organ homeostasis during ageing.

Hobbies and other interests:Reading, Listening to music.

First name:Arpita

Last name:Baisantry


Country:India


Supervisor:Prof. Dr. K. L. Rudolph(now Ulm)

EducationCollege/University:2001-2003 Madurai Kamaraj University M.Sc in Microbial Gene Technology

Highest degree:M.Sc. in Microbial Gene Technology

Major Subjects:Molecular Biology

Projects/Research:1. Rutin like compound from Punica granatum and itsbioactivities.2. Mechanisms of apotosis induced by phytochemicals in BC-8 cells3. cDNA library screening of AK-5 tumor for a ligand for theactivating NK cell receptor NKRP2

Scholarships:1. Junior Research Fellowship (JRF) awarded by Council forScientific and Industrial Research (CSIR), India.3. GATE scholarship

Scientific Interests and Goals:Translational Research ‘From bench to bedside’(and hopefully from mouse to man) : the ability to rapidly transfer new basic scientific knowledge to biomedical knowledge, in order to generate advanced diagnostic and therapeutic applications, at the same time offering new investigation tools. And in pursuit of that I would like to study common mechanisms in inflammation and cancer.But if someone would ask me to state my research interests in one word, then that would be ‘Immunology’

Hobbies and other interests:Music, dance, history ,literature and sports.

First name:Hari

Last name:Balaji


Country:India

E-mail: [email protected]

Supervisor:Prof. Dr. T. WerfelDermatology

EducationCollege/University:M.Sc. Biotechnology [M. Biotech, 2003-2005], Department of

Biotechnology, AIIMS, New Delhi, India.


Major Subjects:Biotechnology [Molecular Biology, Immunology,Cell biology,

Biochemistry, Biostats……]

Projects/Research:Signal transduction and Gene Regulation

Scholarships:1. Have been awarded in the All India Biotechnology Quiz

Competition held at the ‘Centre for Biotechnology ‚ JNU, New Delhi, on the ‘National Science Day‘ 2003.

2. Awarded with Junior Research Fellowship (JRF) by Department of Biotectnology (DBT-JRF, 2005) India, and Indian council of Medical Research (ICMR-JRF,2005) ,India.

3. Lecturership by CSIR, India.

Scientific Interests and Goals:My main field of interest is Cell Biology and Biophysics, and

would be fortunate if could get an opportunity to explore and contribute to the better understanding of the field of Neurosciences and neurodegenarative disorders….

Hobbies and other interests:Music, Instrumental Music (Tabla, Piano, Bongo,… .), Sketching,

Painting, Adventure Sports….etc.

First Name:Kshama

Last Name:Gupta


Country:India


Supervisor:Prof. Dr. K. Welte/ Dr. Julia SkokowaPediatrics, Hematology and Oncology

EducationCollege/University:1998 - 2004 University of Kaiserslautern (Germany)Diploma in Biology in January 2005Title of Thesis: „Analysis of conditional mdr-1 expression in human cells“ Diploma work done at the European Institute for research and development of transplantation strategies (EUFETS, FreseniusBiotech Group)

Major Subjects:Retroviral vectors, haematopoietic stem cell biology

Projects/Research:1) Evaluation and optimisation of „All-in-One“ retroviral vectorsbased on the Tetracycline-regulatory System2) Tet-regulated expression of HoxB4 in haematopoietic (stem) cells3) Tet-regulated expression of chemoresistance genes (MGMT/Mdr-1) in haematopoietic cells

Scientific Interests and Goals:The main interest of my work is to establish an optimized conditional gene expression system which is therapeutically applicable in the field of somatic gene therapy.

Hobbies and other interests:Meeting with friends, music, billard, card-games, soccer,

First name:Niels

Last name:Heinz


Country:Germany


Supervisor:Dr. B. SchiedlmeierProf. Dr. C. Baum Experimental Hematology

EducationUniversity:1997-2003 University Hamburg2000-2003 Medical thesis in the Inst.for Immunology, Hamburg2003-2004 University Lübeck: M.D.-degree2004-2006 Specialist training in neurology, Bad Segeberg

Highest degree:M.D., Dr.med.

Major Subjects:Immunology

Projects/Research:Evaluation of allogeneic versus autologous TCR gene transfer after

hematopoietic stem cell transplantation

Awards:Second poster-price in the 5th Joint Meeting of theSignal Transduction Society (STS), Weimar 2001

Scientific Interests and Goals:My main field of interest: tumor immunology/hematology. Projekt:Improving donor lymphocyte infusions by the use of TCRgene transfer. The impact of TCR gene transfer on graft versus hostdisease (GVHD), graft versus leukemia reactivity (GVL) is analysed in an mouse model for acule myeloid leukemia.

Hobbies and other interests:Playing the mouthorgan, out door activities

Publications:Krebs C., Koestner, W., Nissen M., Welge V., Parusel I., Malavasi F., Leiter E., H.

Santella R., M., Haag, F., Koch-Nolte F. Flow cytometric and immunoblotassays for cell surface ADP-ribosylation using a monoclonal antibody specificfor ethenoadenosine. Analytical Biochemistry 2003, 314(1):108-15.

Krebs C, Adriouch S, Braasch F, Koestner W, Leiter EH, Seman M, Lund FE, Oppenheimer N, Haag F, Koch-Nolte F. CD38 controls ADP-ribosyltransferase-2-catalyzed ADP-ribosylation of T cell surface proteins. J Immunol. 2005;174(6):3298-305.

Ghosh A, Koestner W, Hapke M, Schlaphoff V, Langer F, Baumann R, Koenecke C, Cornberg M, Welte K, Blazar B, Sauer M. Donor T cells primed on leukemialysate-pulsed recipient APCs mediate strong graft versus leukemia effects acrossMHC barriers in full chimeras. Blood. 2009 Jan 30. [Epub ahead of print]

First name:Wolfgang

Last name:Koestner


Country:Germany


Supervisor:PD Dr. M. SauerPediatric Hematology and Oncology

EducationCollege/University:2004-2006 Madurai Kamaraj University, M.Sc. (MGT). 2001-2004 Presidency College, Bangalore University, B.Sc. in Biotechnology.


Major Subjects:Microbial Gene Technology

Projects/Research:Biochemical and functional characterisation of p38MAPK-MAPKAPK2/3 complex. Identification of new downstreamtargets and studying the role of co-ordinated signaling by thecomplex.

Scholarships:1. Junior Research Fellowship (JRF) awarded by Council forScientific and Industrial Research (CSIR), India.2. Bharat Petroleum Scholarship (2004) for higher studiesawarded by Bharat Petroleum Corporation, India.

Scientific Interests and Goals:My main field of interest is Biochemistry. I have always tried and will always try to bring the branches of chemistry and biology together and see life as a set of co ordinated chemical events. I would like to add on to this basic understanding, which can makethings simple and life easier

Hobbies and other interests:Music, Reading, sketching etc.

First name:Manoj

Last name:BalakrishnaMenon


Country:India


Supervisor:Prof. Dr. M. Gaestel/ Dr. Alexey KotlyarovPhysiological Chemistry

EducationCollege/University:2001-2004 : B.Sc. (Hons) Microbiology, University of Delhi,

India.2004-2006 : M.Sc. Biotechnology, A.I.I.M.S, New Delhi, India.

Highest degree:Masters in Biotechnology

Major Subjects:Biotechnology, Molecular Biology, Immunology and Cell biology

Projects/Research:• To study the engraftment potential of multipotent adultprogenitor cells in Fah knockout liver injury mouse model.• To isolate and charecterise GFP positive oval cells in Nestin-EGFP mice..

Scholarships/Awards:Awarded Junior Research Fellowship by Indian Council of Medical Research (I.C.M.R) in Jul 2006Awarded lectureship in NET-CSIR Examination held in Dec 2005Awarded Junior Research Fellowship by Indian council for Agricultural Research in 2004. Received the award for “Best student in microbial World” in graduation.

Scientific Interests and Goals:My main field of interest is Stem Cell Biology.The role of the stem cells in giving rise to different cell types and entire organs for tissue repair and transplants, is what fascinates me the most. I welcome the challenge of serving global community by participating in such a dynamic and challenging field as that ofstem cell liver transplantation. I would consider myself flourishing in my endeavors if I am able to make a sound and humble contribution towards the betterment of patients suffering from liver injuries and failures.

Hobbies and other interests:Traveling to different places,listening to music, dancing and watching movies.

Publications:V. Baniasadi, N. Narain, R. Goswami & S.N. Das. Promoter region –318 C/T and –1661 A/G CTLA-4 Single nucleotide polymorphisms and type 1 diabetes in North Indians. Tissue antigens 2006 : 67 : 383-389.Haridass D, Narain N, Ott M. Hepatocyte transplantation : waititng for stemcells. Current opinions in organ transplantation ( Dec 2008;13(6):627-632)

First name:Nidhi

Last name:Narain


Country:India

E-mail:nidhinarain@@yahoo.com

Supervisor:Prof. Dr. M. OttGastroenterolgy, Hepatology & Endocrinology

EducationCollege/University:2000-2006 Medizinische Hochschule Hannover, Medicine

Highest degree:Dr.med.

Major Subjects:Transplantation Medicine

Projects/Research:1. In vitro studies of the natural killer cell complex: intra- and intercellular response to ligands2. In vivo experiments: the role of the natural killer cell complex in transplantation

Scientific Interests and Goals:Transplantation immunology is of most interest to me. Although there are great progresses done on this field of research a lot of pathomechanisms leading to graft loss or acceptance are still not known yet. It is my effort to gain a deeper insight of those mechanisms and to transfer this knowledge to clinical practice.

Hobbies and other interests:music, sports, movies, literature, etc.

Publications:Koch M., Mengel M., Poehnert D., Nashan B.: Effects of Everolimus on cellular and humoral immune processes leading to CAN in a rat model with sensitized recipients. Transplantation 2007; 83(4): 498-505.

First name:Poehnert

Last name:Daniel


Country:Germany


Supervisor:Dr. M. Koch/ Prof. KlempnauerVisceral Surgery

Education University:2001-2006 Universität Hannover

Highest degree:Diplom-Biologe

Major Subject:Biophysics

Projects/Research:Motor Mechanics of Cytoplasmic Dynein

Scientific Interests and Goals:Molecular motors like cytoplasmic dynein are the heart of almost all biological transport processes, whether in organized structures, such as in muscles and axonemes or acting in isolation to move single sub-micron-sized cargo. Understanding of the molecular interaction during the forcegenerating cycle and its regulation are still at an elementary stage. That is why I am working on cytoplasmic dynein's motor mechanics.

Scholarships:

Boehringer Ingelheim travel fellowship (2007)

Maurice Mueller fellowship (2009)

Publications:

Walter, Brenner, and SteffenCytoplasmic dynein is not a conventional processive motor.J Struct Biol. 2009 Dec 2. [Epub ahead of print]

Bintig, Baumgart, Walter, Heisterkamp, Lubatschowski, and NgezahayoPurinergic signalling in rat GFSHR-17 granulosa cells: an in vitro model of granulosa cells in maturing follicles.J Bioenerg Biomembr. 2009 Feb; 41(1):85-94.

Walter, Zeilinger, Bintig, Kolb, and Ngezahayo Phosphorylation in C-Terminus of the Rat Connexin46 (rCx46) and Regulaton of the Conducting Activity of the Formed Connexons.J Bioenerg Biomembr. 2008 Aug; 40(4):397-405

First name:Walter

Last name:Wilhelm


Country:Austria


Supervisor:PD Dr. Walter SteffenMolec. and Cell Physiology

EducationCollege/University:2000-2005 Carl von Ossietzky University, Oldenburg

Highest degree:Dipl. Biology

Major Subjects:Molecular Immunology

Projects/Research:Gαi-dependent leukocyte migration during IC mediated lung

inflammation

Scholarships:GRK 705 II „ Characterization of pathophysiological

animal models“, Medical School Hanover

Scientific Interests and Goals:My main field of interest is gene regulation and

signaltransduction in the immune system. I would like to understand some of the complex mechanism which providethe basis for the diverse organisation of the immune system.

Hobbies and other interests:Scuba Diving, Photography, Motorbike

First name:Kristina

Last name:Wiege


Country:Germany


Supervisor:Prof. Dr. J.E. GessnerClinic for Immunologyand Rheumatology

EducationCollege/University:2001-2004 Peking Union Medical College, P.R. China

Highest degree:M.Sc. In Molecular Immunology

Major Subjects:Immunology, Medicine

Projects/Research:1.Identification of alternative spliced isoforms of hIL-23R2.The role of IFN gamma on tumor stroma cells3.The role of stroma cells (including mesenchymal stem cells) in the

functional organization of lymphoid organs

Scholarships:Medical Education Scholarship of The United Laboratories (Hongkong) in the Medical Universities of mainland China, Golden Prize (1998-1999)

Scientific interests and goals:Immune system is quite fancy, finding something novel and interesting in basic immunological areas is my long term goal. My scientific goal during Ph.D study is to identify something new on stroma cells of lymphoid organs, e.g. what’s the special subset marker, how they function on the interactions of different immune cells especially their migration during the development of lymphoid organs and immune reactions. Besides this I also quite like transcriptional and epigenetics control of lymphocytes, in their functional differentiation and memory, etc.

Hobbies and other interests:Hiking, Music, Reading

Publication List:Xiangyue Zhang, Shuhui Wang. Progress in the study of IL-23 and IL-23 receptor,BasicMedical Sciences and Clinics,August, 2004; 24(4), p457-461.

Xiangyue Zhang, Zhiguang Li, Zhihai Qin. Cancer Immunosurveillance or not? (New view), Progress in biochemistry and biophysics, November,

2005;32(11), p1093-1098.

Xiangyue Zhang, Li Liu, et al. Alternative Splicing of Human IL-23 Receptor Gene Generates Multiple Isoforms in Selected Tumor Cell Lines. Immunogenetics, 2006 Jan;57(12):934-43

First name:Xiangyue

Last name:Zhang


Country:P. R. China


Supervisor:Prof. Dr. R. FörsterImmunology

year 2007

Rakesh Kumar Bakschi

Vijay Kumar Chennupati

Sheetal Ramachandran Chettiar

Sadaf Kasraie

Katja Kochrübe

Daniel Kotlarz

Jayendra Kumar Krishnaswamy

Jan Larmann

Subhashree Mahapatra

Ankita Minhas

Susann Müller

Mudita Pincha

Harald Schütt

Adrian Schwarzer

Theodros Solomon Tsegaye

Usriansyah

Susanne Wolf

EducationCollege/University:2002-2005- Delhi University Bachelors in Biochemistry (Honours)2005-2007-Madurai Kamaraj University, Masters in Biotechnology



Projects/Research:Role of heterologous immunity for natural resistance to HCV infection (current project).

Scholarships:1.CSIR JRF 2007(INDIA)2.DBT JRF(all India rank 14)3.Gate 97+percentile (INDIA).4.Budding scientist Award from Ukkunagram Club Visakhapatnam (INDIA)5. DBT Fellowship by Government of INDIA.6.CISF Personal Scholarship by ministry of home affairs Government of INDIA.7.Mahavir Sundaran Endowment Award for the outstandingperformance in Academics(MKU INDIA).

Scientific Interests and Goals:My main feild of interest is the immunology of viruses and I wish to study the biology behind the success of the viruses to infect and thefailure of human immune system , in order to understand the virusrelated diseases in a better way and then to find their remedies in a natural way.

Hobbies and other interests:1.Adventurous activities like mountaineering, paragliding etc.2.Sports like badminton, cricket etc

First name:Rakesh

Last name:Bakshi


Country:India

E-mail:[email protected]@mh-hannover.de

Supervisor:Dr. H. WedemeyerGastroenterology, Hepatology and Oncology

EducationCollege/University:2001-2003 Acharya Nagarjuna University, AP, India.

Highest degree:M.Sc. in Biochemistry

Major Subjects:Biochemistry and Molecular Biology

Projects/Research:γδ T lymphocyte migration, homing and site-specific function

Scientific Interests and Goals:Always I used to fascinate at the way a tiny cell programmes

itself for it’s own destiny .May be this includes hundreds of thousands molecules coordinated signalling or the way it executes it’s own programme at a specific pre-determined time. It’s just funny to think that a mega or gega Computer (human) is working all the time just to know about a micro system (cell). I used to believe in the concept “bedside to bench and bench to bedside”, as it evenly facilitates the flow of research knowledge into the field of medicine for effective treatment(s).

My scientific interest always finds it’s partner in the broader area of cell signalling .Currently I am working on some of the questions regarding γδ- T cells (Unconventional T cells) migration, homing and their role. Structural and multifaceted functional conservation of this γδ –T cells appears as a promising answer against many unsolved questions in the field of Immunology. Last but not least, It would be a great fortune for me If I get a chance to study and contribute something to the pathways of human emotions, pain and their interrelationship. .

Hobbies and other interests:Movies, Music, Cricket, and Reading gossips about film stars .

First name:Vijay

Last name:Kumar


Country:India

E-mail:[email protected]@mh-hannover.de

Supervisor:Dr. Immo Prinz,Institute of Immunology

EducationCollege/University:2004-2006 Madurai Kamaraj University, M.Sc. in MGT2001-2004 University of Kerala, B.Sc. in Biotechnology


Major Subjects:Microbial Gene Technology

Projects/Research:Working on characterization of THO complex member THOC5/FMIP in pre-mRNA processing and transport and its involvement in DNA damage signaling.

Scholarships:GATE scholarship, 2007

Scientific Interests and Goals:My main area of interest is applied biology or therapeutic field of medicine. I would like to work on areas where productive resultsshould come out that will make the life of suffering people easier.

Hobbies and other interests:Listening to music, dancing.

First name:Sheetal

Last name:Ramachandran


Country:India


Supervisor:Prof. Dr. Tamura-NiemannInstitute of Physiological Chemistry

EducationCollege/University:2000-2004 Azad University, BSc in Microbiology.

2006-2004 Azad University, Research and Science of Tehran,M.Sc in Microbiology.

2007-2005 Research Assistance in National Institute for GeneticEngineering & Biotechnology,Tehran, Iran.

Highest degree:M.Sc. in Microbiology

Major Subjects:Molecular Medicine (Genetics & Immunology)

Projects/Research:Dysregulation of innate and adaptive immunity in patients withatopic dermatitis: imapact of IL-31/IL-31RA

Award and Scholarship:1.Certificate of first ranked student in MSc of Microbiologywhich is awarded by Azad University .(January 2007)2. Certificate of first ranked student in BSc of Microbiologywhich is awarded by Azad University.(January 2004)

Scientific Interests and Goals:Investigation on immune mechanisms of Immunodeficiency diseases, Skin Inflammation, Hypersensitivity ,and Allergy. This field of study can provide us new insight into development of therapeutic strategies in these disorders.

Hobbies and other interests:Painting , Playing the Piano, Dancing,etc.

Publications:Ahari S,Houshmand M,Kasraie S,Shafa M,Moin M,Bahar M A.Investigationfor point mutations on mitochondrial tRNA lys/leu ,NDI and ATPase 6/8 in IranianMultiple Sclorosis Patients.Cell Mol Neurobiol 2007; 27 (6):695-700.

Kasraie S, Houshmand M, Banoei MM, Ahari SE, Panahi MS, Shariati P, Bahar M, Moin M. Investigation of tRNA(Leu/Lys) and ATPase 6 genes mutations in Huntington's disease. Cell Mol Neurobiol. 2008; 28(7):933-8

First name:Sadaf

Last name:Kasraie


Country:Iran


Supervisor:Prof. Dr.Thomas WerfelDepartment of Dermatology & Allergology

EducationCollege/University:2001 – 2007 University of Bayreuth, Diploma in Biochemistry

Highest degree:Diploma in Biochemistry

Major Subjects:Biochemistry

Projects/Research:Topic of diploma thesisIdentification of proteases responsible for the degradation of proteins with a proteolytic tag in Bacillus subtilis

Current topic at the Helmholtz Centre for Infection ResearchMechanisms of tumour colonization by Salmonella typhimurium

Scholarships:1. Scholarship for scientific books from Dehmel Foundation,

Schwarzheide2. Scholarship for PhD studies from Helmholtz Centre for

Infection Research

Scientific Interests and Goals:For me Immunology is an attractive area in science . This broadresearch field has still a lot of open questions, which I want to help finding answers for. Especially interesting are the processesof the immune system during tumour establishment.

Hobbies and other interests:Sports (Fitness and Volleyball), Painting

First name:Katja

Last name:Kochrübe


Country:Germany


Supervisor:Dr. S. WeissMolecular ImmunologyHZI Braunschweig

EducationCollege/University:2003-2005 University of Mumbai, B.Sc. (Microbiology,

Vocational Biotechnology)2005-2007 Pondicherry University, M.Sc (Biotechnology).



Projects/Research:Antigenic targeting of dendritic cell subsets for tolerance

induction to inhaled antigens.

Scholarships:1. Awarded by Dept. Of Biotechnology (DBT), India for

selection in All India Combined M.Sc. Biotechnologyprogramme (2005-2007).

2. Junior Research Fellowship (JRF) awarded by Dept. Of Biotechnology (DBT), India.(2007). (All India Rank 8)

3. Qualified GATE-2007 Examination for Research Fellowship granted by Government of India (All India Rank 131)

Scientific Interests and Goals:Clinical Immunology. Current intrests include studies on Dendritic cell subsets, Antigen presentation pathways and their regulation and Antigen targeting to specific DC subsets.

Hobbies and other interests:Cricket, Books, Travel, etc.

First name:Jayendra Kumar

Last name:Krishnaswamy


Country:India


Supervisor:Prof. Dr. Georg BehrensDept. of ClinicalImmunology

EducationCollege/University:1998 - 2005 University of Muenster Medical School, Germany2004 Tufts University Medical School, Boston, MA, USA

Highest degree:MD

Projects/Research:HDL-mimetics and sphingophosholipids for rapid stabilization of atherosclerotic lesions

Scholarships & Awards:*2006-2007 Postdoctoral Fellowship, Interdisciplinary Center for

Clinical Research, Faculty of Medicine, University of Muenster*2006 Recognition award for outstanding doctoral thesis project,

awarded by the president of the Univ. of Muenster, Germany*2003-2004 Biomedical Sciences Exchange Program, Hannover*2003 Scholarship, Dr. Carl-Duisberg Foundation

Scientific Interests and Goals:Help to tackle adverse inflammatory response by its molecular roots and develop optical and molecular imaging applications to gain deeper insights in inflammation and tissue regeneration.

Hobbies and other interests:Music (Dresden Dolls, Arcade Fire, HtH...), Movies (Jim Jarmusch, Richard Linklater), Contemporary Art (Hirst, Richter...)

Publications:Theilmeier G, Schmidt C, Herrmann J, Keul P, Schäfers M, Herrgott I, Mersmann J, Larmann J, Hermann S, Stypmann J, Schober O, Hildebrand R, Schulz R, Heusch G, Haude M, Wnuck Lipinski von K, Herzog C, Schmitz M, Erbel R, Chun J, Levkau B. High-Density Lipoproteins and Their Constituent, Sphingosine-1-Phosphate, Directly Protect the Heart Against Ischemia/ Reperfusion Injury In Vivo via the S1P3 Lysophospholipid Receptor. Circulation. 2006;114:1403

Larmann J, Schmidt C, Gammelin H, Van Aken HK, Frenzel T, Lanckohr C, Lox M, Boese N, Jurk K, Theilmeier G. ICAM-1-Inhibition ameliorates neurological and hepatic damage after resuscitation in mice. Anesthesiology 2005, 103: 1-6

Larmann, Theilmeier. Inflammatory response to cardiac surgery: cardiopulmonary bypass versus non-cardiopulmonary bypass surgery. Best Pract Res Clin Anaesthesiol. 2004;18(3):425 (Review)

please also visit: �http://www.openwetware.org/wiki/Jan_Larmann

First name:Jan

Last name:Larmann


Country:Germany


Supervisor:Prof. TheilmeierExperimental Anesthesiology

EducationCollege/University:2002-2005 AIIMS ; B.Sc. In Human Biology2000-2002 School of Biotechnology,JNU; M.Sc in Biotechnology.


Major Subjects:Biotechnology. Biochemistry

Projects/Research:Immunology

Scholarships:1. Awarded by DBT,india for selection in All india combined M.Sc. biotechnology programe (2005-2007).2. Junior Research Fellowship (JRF) awarded by Council for Scientificand Industrial Research (CSIR), India.3. R&D Assistantship from JNCASR, Bangalore, India.

Scientific Interests and Goals:My areas of interest are cancer research and immunology. My ambition is to add to the knowledge that will ultimately help us to understand this fascinating area of biology better.

Hobbies and other interests:Painting, Music, Movies, Exploring new places, etc. .

First name:Subhashree

Last name:Mahapatra


Country:India


Supervisor:Dr. DittrichSFB 587

Education (College/University):2001-2004 Bachelors in biochemistry, Delhi University2003-2007 Masters in Biotechnology, Hamdard University

New Delhi

Highest degree:M.Sc

Major Subjects:Bichemistry and Biotechnolgy

Research project topic:The use of morpholino based knockdown gene technology as well as genetic studies to determine the function of HAX1 in zebrafish.

Scholarships:1.Received scholarship by the Central Board for SecondaryEducation (CBSE) for being among the top 0.1% of students in mathematics in India (1999)2.Junior research fellowship (JRF) from DBT to work in International Centre for genetic engineering and biotechnology(ICGEB), Virology group.

Scientific Interests and Goals:As a student trained to correlate genotype and phenotype and seekanswers from genes im keen to explore the defects at genetic\genomic level that are responsible for various geneticdiseases including cancer.My project aims at understanding thebiological role of HAX1,a molecule defective in patients with a life threatening condition called severe congenital neutropenia. For which we would use zebrafish model system to analyse thefunction of HAX1.

Hobbies and other interests:Singing, Athletics, Astrology

First name:Ankita

Last name:Minhas


Country:India


Supervisor:Prof. KleinDepartment of PediatricHematology and Oncology

EducationCollege/University:2002-2007 Friedrich Schiller University Jena,

Biochemistry (Diplom)

Highest degree:Diplom in Biochemistry

Major Subjects:Molecular Medicine

Projects/Research:Identification of cardiogenic factors in a Rhesus monkeyembryonic stem cell model

Scientific Interests and Goals:The focus of interest in my work is on signalling in Rhesus monkey embryonic stem cells. I aim at identifying essential signals and their pathways directing these cells towardscardiomyocytes. If I am successful, it should be possible to generae cardiomyocytes in high yield and efficiency for artificialcardiac tissue or cell transplantation research.

Hobbies and other interests:Astronomy, Literature, Walking and Baking

First name:Susann

Last name:Müller


Country:Germany


Supervisor:Prof. Martin,Leibniz Laboratories forBiotechnology and Artificial Organs

EducationCollege/University:2001-2004 Bangalore University, B.Sc. In Microbiology2005-2007 Bangalore University, M.Sc in Biochemistry.

Highest degree:M.Sc. in Biochemistry


Projects/Research:Lentivirus programmed dendritic cells for immunotherapy of

melanoma

Scholarships and Awards:1. Sixth Rank in Bangalore University (Bsc. 2005.)2. Academic Excellence Award in Bsc. by M.S.Ramaiah

Degree College (Feb 2004)3. Academic Excellence Award by Bhagawan Mahaveer Jain

College (May 2006)

Scientific Interests and Goals:Construct and design lentiviral vectors to produce dendritic cell

vaccines against cancer and various infectious diseases.Research in this area is at the forefront of clinical trials, the major hurdle now being the construction of safer viral vectors and understanding the working and immunology of the dendritic cell vaccines. I hope to contribute to the following in the coming years.

Hobbies and other interests:Books, Music, Poetry,Adventure Sports.

First name:Mudita

Last name:Pincha


Country:India


Supervisor:Dr. Renata StripeckeLymphoid Cell TherapyLaboratory.Department of Hematolgy, Oncology and Hemostasiology.

EducationCollege/University:2000-2006 University of Rostock, Human Medicine

Highest degree:M.D.

Major Subjects:Human Medicine

Projects/Research:Investigation of cytokine signalling mechanisms in the course of

atherosclerosis

Scholarships and Awards:1. Participant of the 57th Nobel Laureate Meeting 20072. Class rank 1 graduate at the Faculty of Human Medicine,

University of Rostock 2006

Scientific Interests and Goals:I am generally interested in the pathophysiology of cardiovascular

diseases and want to gain a deeper insight in thebiomolecular mechanisms of initiation and progression of those. My primary goal in doing so is to become competentin the interconnection of good clinical and scientifical work.

Hobbies and other interests:music (from pop to electronic), sports - especially endurance

running and basketball, movies (e.g. from quentin tarantinoand guy ritchie)

Publications:Cantré D, Schuett H, Hildebrandt A, Dold S, Menger MD, Vollmar B, Eipel C. Nitric oxide reduces organ injury and enhances regeneration of reduced-size livers by elevation of hepatic arterial flow. BJS. 2007; accepted.Schuett H, Eipel C, Maletzki C, Menger MD, Vollmar B. NO counterbalances HO-1 overexpression-induced acceleration of hepatocyte proliferation in mice. Lab Invest. 2007;87:602-12.Eipel C, Eisold M, Schuett H, Vollmar B. Inhibition of hemeoxygenase-1 protects against tissue injury in carbon tetrachlorideexposed livers. J Surg Res. 2007;139:113-20.Eipel C, Schuett H, Glawe C, Bordel R, Menger MD, Vollmar B.Pifithrin-alpha induced p53 inhibition does not affect liver regenerationafter partial hepatectomy in mice. J Hepatol. 2005;43:829-35.

First name:Harald

Last name:Schuett


Country:Germany


Supervisor:Prof. Dr. med. SchiefferCardiology

EducationCollege/University:2007 M.D.2006-2007 Norris-Cotton-Cancer-Center,

Dartmouth Medical School, Hanover, NH2000-2007 Study of Medicine,

Technical University of Dresden

Highest degree:MD

Major Subjects:Medicine, Immunology, Molecular Biology

Projects/Research:1.Molecular characterization of mouse models of leukemia2.Mechanisms of induction of immunologic tolerance byleukemic cells3.Gene therapy for hematologic disorders

Scholarships:1.Studienstiftung des deutschen Volkes 2.Bayer Studienstiftung3.Scholar of the Biomedical Exchange Program (BMEP) of theInternational Academy of Life Sciences (IALS)

Scientific Interests and Goals:My main field of interest is elucidating the molecular relations between leukemia and the human immune systeme. We havefound that leukemic cells induce paralysis of several compoundsof the immune system and we wish to further investigate themechanisms of this phenomenon and design strategies via genetransfer into hematopoetic stem cells to overcome tumor inducedtolerance.

Hobbies and other interests:Cycling, running, reading, traveling

First name:Schwarzer

Last name:Adrian


Country:Germany


Supervisor:Prof. KleinExperimental PaediatricHematology & Oncology

EducationCollege/University:2000-2006 Jimma University, School of Medicine,Degree of

Doctor of Medicine,MD(with Hons)

Highest degree: M.D

Major Subjects:Medicine

Projects/Research:1. HIV interaction with platelets: the role of CLEC- 2 and DC-

SIGN receptors.

Scholarships:1. The JU-LMU link for Medical Education, Ludwig-Maximilians

University, Munich,Germany (July 2006)

Scientific Interests and Goals:I am highly interested in the pathogenesis and spread mechanismsof infectious diseases, particularly virus-mediated ones. I would love to explore and have an in depth insight into the interface between infection and immunity. By doing this, I aspire to have a career as a physician-scientist searching for break-throughfindings that could set free human life out of suffer; easy cure and prevention of infectious diseases in the clinics.

Hobbies and other interests:Reading, journalism, radio, music, surfing the net, friends…

First name:Theodros

Last name:Solomon Tsegaye


Country:Ethiopia

E-mail:[email protected]@gmail.com

Supervisor:Prof. PöhlmannInstitute of Virology

EducationCollege/University:1997-2002 Institut Teknologi Bandung, Indonesia, Bachelor of Pharmacy2002-2003 Institut Teknologi Bandung, Indonesia, Professional Degree(Pharmacist)2005-2007 Diamantina Institute for Cancer, Immunology and MetabolicMedicine, University of Queensland, Australia, Master of Philosophy in Immunology

Highest degree:M.Phil in Immunology


Projects/Research:The structural, cellular and molecualr basis of intestinal tolerance

Scholarships:1. Institut Teknologi Bandung Academic Achievement Scholarship(1998-1999)2. Unilever Top Student Scholarship (2000-2002)3. Australian Government Scholarship (Masters Degree, 2005-2007)

Scientific Interests and Goals :My specific field of interest is studying the correlation between cytokines and chemokines and their interaction with T cells development, activation, trafficking and regulation which may be useful in targeting immunotherapy for the diseases. My big goal is to be able to contribute to global competition in science particularly in immunology.

Hobbies and other interests:Dance, Music, Movies, Traveling

Publications :Jie Zhong, Usriansyah Hadis, Rachel de Kluyver, Germain Fernando, Grahan R. Leggatt, Ian Frazer, TLR 7/8 stimulation augments T effector mediated rejection of skin expressing neo-self antigen in keratinocytes, The European Journal of Immunology, in Press

First name:Usriansyah

Last name:Hadis


Country:Indonesia


Supervisor:PD. Dr. Oliver PabstInstitute of Immunology

EducationCollege/University:2001-2003 Johannes Gutenberg-Universität Mainz,

Pre-Diploma in Biology2003-2004 Cardiff University, Department of Biochemistry2004-2007 Johannes Gutenberg-Universität Mainz,

Diploma in Biology

Highest degree:Diploma in Biology

Major Subjects:Molecular Genetics, Physiological Chemistry, Microbiology

Projects/Research:Synergistic effects of histone methylation defects and oncogeneactivation and their contribution to the induction of chromosomalinstability in leukemogenesis

Scholarships:2004: Awarded by Erasmus exchange programme2006: Awarded by Johannes Gutenberg-Universität Mainz

for Diploma thesis

Scientific Interests and Goals:To get a better understanding of the mechanisms underlyingleukemogenesis. In particular which factors induce chromosomalinstability and how does chromosomal instability lead to maligntransformation.

Hobbies and other interests:Music, Literature, Sailing, Gardening, etc.

First name:Susanne

Last name:Wolf


Country:Germany


Supervisor:Prof. Schlegelberger,Cell and MolecularPathology

year 2008

Andrea Autengruber

Kiran Bala

Rajkumar Bhayadia

V. Krishna Chaitanya

Tamaryin Godinho

Dirk Heckl

Yarua Jaimes

Daniela Kieneke

Annika Kühl

Elena Lam

Hui Zhi Low

Aliaksandra Maroz

Martin May

Vanessa Melhorn

Pooja Mishra

Dhaarini Murugan

Nils Pfaff

Tim Ripperger

Volker Rust

Ayesha Sultan

EducationCollege/University:•2003-2006 Paris Lodron University Salzburg, B.Sc. in Geneticsand Molecular Biology.•2006-2008 Paris Lodron University Salzburg, MA.Sc in Geneticsand Biotechnology.

Highest degree:MA. rer.nat.


Projects/Research:Current project at MHH:„Characterization and manipulation of type II alveolar epithelialcell function in T cell mediated pulmonary inflammation“

Scholarships:FWF financial support during diploma thesisMD/PhD program

Scientific Interests and Goals:My main field of interest is concentrating on immunology in common. In particular, disease on the basis of immunology, ranging from cellular background and mechanism to possibleclinical treatments.

Hobbies and other interests:Sports, Friends, Literature, Movies, Art, Travels, Music

First name:Andrea

Last name:Autengruber


Country:Austria


Supervisor:Prof. BruderImmune Regulation,HZI Braunschweig

EducationCollege/University:2001-2004 Nagarjuna University, B.Sc. In Microbiology,

Biochemistry, Chemistry2004-2006 Banaras Hindu University, M.Sc in Biochemistry.

Highest degree:M.Sc. in Biochemistry.


Projects/Research:

Development of an animal model to test the in-vivo function of theKaposi Sarcoma Herpes Virus K15 protein.

Scholarships:1.Research fellowship to pursue PhD awarded by Indian Council

of Medical Research (ICMR). 2.Qualified for Lecturership awarded by the Council of Scientific nad

Industrial Research (CSIR). 3. Secured All India 14th rank in GATE 2006.4. Summer Research fellowship to undergo a summer training awarded by

Jawaharlal Nehru Centre for Advanced and Scientific Research (JNCASR) in May 2005.

Scientific Interests and Goals:My main field of interest is Virology. I want to study role of K15 proteinof KSHV in the mechanism of the invasion and migration of virus in thecells.

Hobbies and other interests:Music, Movies, playing badminton etc.

First name:Kiran

Last name:Bala


Country:India


Supervisor:Prof. SchulzInstitute of Virology

EducationCollege/University:2002-2006 G.B. Pant University of Agriculture and Technology, B.Sc. In Agricultural Sciences2006-2008 Jawaharlal Nehru University, M.Sc in Life Sciences.

Highest degree:M.Sc. in Life Sciences

Major Subjects:Molecular Biology, Biochemistry,Human Genetics, Cell Biology, Immunology etc.

Projects/Research:Research project at Jawaharlal Nehru UniversityCharacterization of a novel rat cDNA with repeat sequences:Implications for the rat piRNACurrent Project at HBRSImportance of Proteasomes in cell cycle regulation and developmentof anticancer therapeutics.

Scholarships:1. National Talent Scholarship (2002-2006) awarded by Indian Agriculture Research Institute in BSc. 2. Junior Research Fellowship (JRF) 2007 awarded by Council for Scientific and Industrial Research (CSIR), India.

Scientific Interests and Goals:My main field of interest is Molecular Cell Biology. Cancers puzzle me. I aspire to build a successful career as a scientist and independent investigator. In long-term I want to contribute more to my country by developing it in a strong nation in terms Science and Technology.

Hobbies and other interests:Music, Cricket, Movies, Reading Novels etc.

Publications:None

First name:Raj Kumar

Last name:Bhayadia


Country:India


Supervisor:Prof. Dr.med. Nisar P. MalekDept. of Gastroenterology, Hepatology and Endocrinologyand Institute for Molecular Biology

EducationCollege/University:2007-2008 National Center for Biological Sciences, JRF2005-2007 Sri Ramachandra University, M.Sc in Biotechnology2002-2005 Sri Bhagawan Mahaveer Jain College,

B.Sc. (Biotechnology, Genetics, Biochemistry)



Projects/Research:Current Project at HBRS:Role of Urokinase receptor in mobilization and differentiation

of mesenchymal stem cells: impact on blood vessel repair after vascular injury and organ transplantation.

Research Project at NCBS:Identification and Charecterization of Cervical Cancer Stem

Cells and its Implication in Cancer Initiation and Metastasis.

Scholarships:1. Junior Research Fellowship (JRF) at National Center for

Biological Sciences (NCBS), India.3. Qualified Graduate Aptitude Test in Engineering (GATE),

India.

Scientific Interests and Goals:My main field of interest is Stem cell Biology, My goal is, a career in research and educating people in science

and to achieve deep personal satisfaction from my work and in doing so hope to attain an unprecedented level of excellence in the intriguing world of research.

Hobbies and other interests:Acting, Movies, Music, Karate etc...

Publications:Krishna Chaitanya V, Jonnala Ujwal Kumar, Edible Vaccines, Sri

Ramachandra Journal of Medicine, 2006 Sep:vol I(1):33-34

First name:Krishna C

Last name:Vallabhaneni


Country:India


Supervisor:Prof. DumlerExperimental Nephrology

First name:Yarúa

Last name:Jaimes Becerra


Country:Venezuela


Supervisor:Prof. BlasczykDepartment of Transfusion Medicine

EducationCollege/University:2001-2006 Universidad de Los Andes. Diplom in Biology.

Highest degree:Diplom in Biology.

Major Subjects:Molecular Biology, Immunology.

Projects/Research:1. Decreasing the immunogenicity of cell based therapeutics

by regulating the expression of HLA class II and adhesion molecules.

Scholarships:1. Teaching assistantship in General biology and Cell

Regulation. Universidad de Los Andes, 2004- 2006. 2. PhD scholarship, Fundación Gran Mariscal de Ayacucho

(FUNDAYACUCHO) and the German Academic Exchange service (DAAD), 2007.

Scientific Interests and Goals:My current scientific interest is focus on immunogenetics areas,

mainly in the development of new strategies to achieve tolerance in allogeneic transplantation.

Hobbies and other interests:Literature, Languages, Latin American dances, Music, Movies.

EducationCollege/University:2002-2007 Leibniz University of Hannover / Hannover Medical School; study of biochemistry (diplom)

Highest degree:Diplom Biochemist

Major Subjects:Biochemistry, Biophysical Chemistry, Virology

Projects/Research:Biochemical Characterization of the recruitment of host factors such as microtubule motors and importins to the capsid of Herpes-Simplex-Virus

Scholarships:Studienstiftung der ehemaligen Riedel-de Haen GmbH (2005-2007: Honeywell, Seelze GmbH)

Scientific Interests and Goals:My main field of interest is Virology. I analyze the cell biology of Herpes Simplex Virus type 1. I want to study the intracellular transport of viral capsids, and how they recruit the host microtubule motors to catalyze their transport inside cells and host nuclear import factors for binding to the nuclear pore. These host factors are essential for efficient delivery of the vector genome into the nucleoplasm. If we would be able to understand this mechanism at the molecular level, we would be able to optimize viral vectors such that they are efficiently targeted to the host cell nucleus.

Hobbies and other interests:Tennis, Badminton, Inline-Skating, reading

Ongoing Projects:Radtke K, Kieneke D, Wolfstein A, Steffen W, Sodeik B. Kinesin binding to capsids of Herpes Simplex Virus type 1 requires inner tegument proteins. Manuscript in preparation

First name:Daniela

Last name:Kieneke


Country:Germany


Supervisor:Prof. SodeikVirology

EducationCollege/University:2002-2005 University of Lübeck, B.Sc. in Molecular Life Science2006-2008 University of Lübeck, M.Sc. in Molecular Life Science

Highest degree:M.Sc. in Molecular Life Science

Major Subjects:Molecular virology

Projects/Research:CAML, Tetherin and Vpu: Molecular studies and clinical relevance of a new potential therapeutic target in HIV-infection.

Scientific Interests and Goals:I am fascinated by how such tiny species as viruses manage to escape our immune system. Because HIV is one of the experts in escaping the cellular defense mechanisms I choose this extraordinary interesting project to elucidate the mechanism of how vpu targets the recently discovered host restriction factors CAML and tetherin.

Hobbies and other interests:Horseback riding, photography, traveling, languages

Publications:Boxhammer S, Glaser S, Kühl A, Wagner AK, Schmidt CL. Characterization of a recombinant Rieske [2Fe-2S] proteins HcaC and YeaW from E.coli. Biometals. 2008 Aug. 21(4):459-467.

Mamat U, Meredith TC, Aggarwal P, Kühl A, Kirchhoff P, Lindner B, A Hanuszkiewicz A, Sun J, Holst O, Woodard RW. Single amino acid substitutionsin either YhjD or MsbA confer viability to viability to 3-deoxy-d-manno-oct-2ulosonic acid-depleted Escherichia coli. Mol Microbiol. 2008 Feb. 67(3):633-648.

First name:Annika

Last name:Kühl


Country:Germany


Supervisor:Prof. G. Behrens (Clinicfor Imunology and Rheumatology)Prof. S. Pöhlmann (Virology)

EducationCollege/University:2003-2006 University of Applied Sciences Bonn-Rhein-Sieg,

B.Sc. In Biology.2006-2008 University of Applied Sciences Bonn-Rhein-Sieg,

M.Sc in Biology with Biomedical Sciences.

Highest degree:M.Sc in Biology with Biomedical Sciences.

Major Subjects:Biomedical Sciences.

Projects/Research:Investigation into the role of ILT6 in immunomodulation and in autoimmune diseases and cancer.

Scholarships:1. Kölner Gymnasial-und-Stiftungsfonds (2007).2. Richard Winter Stiftung (2006-2007)

Scientific Interests and Goals:I am interested in the study of immunological diseases, in whichhow such a highly fine tuned immune system can go awry and also the possible therapeutic options. I hope to be able to contribute new knowledge which would be of help in thetreatment of these diseases, and in the process also learn newthings and techniques.

Hobbies and other interests:Reading, computer games.

First name:Hui Zhi

Last name:Low


Country:Singapore


Supervisor:Prof. Dr. Torsten WitteClinic for ClinicalImmunology

EducationCollege/University:2003-2008 Belarusian State University, Dipl. in Biology

Highest degree:Diplom in Biology

Major Subjects:Genetics

Projects/Research:Molecular mechanisms of GATA1s-mediated transformation of hematopoietic progenitor cells.

Scholarships:1. Stipend of the Belarusian State University (2003-2007).2. Stipend of the Ruhr University, Bochum (09.2007-02.2008)

Scientific Interests and Goals:My main interests lie in cancer biology and hematology. I am fascinated to study the interplay of factors, leading to normal ormalignant hemopoiesis.

Hobbies and other interests:Theater, literature, foreign cultures, psychology, camping, canoeing.

First name:Alexandra

Last name:Maroz


Country:Belarus


Supervisor:Dr.med. KlusmannPediatric Oncology and Hematology

EducationCollege/University:2002 - 2007 Tech. Univ. Braunschweig, Diploma „Biology“

Highest degree:Diploma in Biology

Major Subjects:Plant and Cell Biology

Projects/Research:Regulation of RNA export and translation in retroviruses: the interplay of quality control and processing signals

Scientific Interests and Goals:To deepen my acquired knowledge about regulated gene expression in the post genome era using viruses as tools I wouldlike to work on virological aspects of regulation of gene expression and corresponding technologies in a well established network of basic and clinical research in close proximity.

Hobbies and other interests:playing piano, volleyball

Publications:Melhorn V, Matsumi K, Koiwai H, Ikegami K, Okamoto M, Nambara E, Bittner F, Koshiba T. (2008): Transient expression of AtNCED3 and AAO3 genes in guard cells causes stomatal closure in Vicia faba. J Plant Res., Jan;121(1):125-31.

Zychlinski D, Erkelenz S, Melhorn V, Schaal H, Baum C, Bohne J (2008): Interplay of secondary structure and limited pairing to U1 snRNAresults in dual attenuation of a retroviral 5’ splice site. Submitted.

First name:Vanessa

Last name:Melhorn


Country:Germany


Supervisor:Dr. BohneInstitute of Virology

EducationCollege/University:3/2007-9/2008 National Institute of Immunology, Jr. Project Fellow2004-2006 Chatrapati Shahuji Maharaj University, M.Sc. Biotechnology2001-2004 Lucknow University, B.Sc. (Botany,Chemistry,Zoology)



Projects/Research:Current Project at HBRS:The spatio-temporal distribution of regulatory T cells during chronic

organ rejection.Research Project at NII:Development and validation of a simple test using gold

nanoparticles/quantum dots and latex beads for DNA based diagnosis of Mycobacterium tuberculosis.

Scholarships/Awards:1. Department of Biotechnology Fellowship at National Institute of

Immunology (NII), India.2. Best presentaion award from Acworthy Leprosy Hospital Research

Society, India.

Scientific Interests and Goals:My main field of interest is Immunology. My goal is to provide answers

to unresolved problems involving comprehensive and fuctionalaspects of research.

Hobbies and other interests:Reading, Playing basketball, Music etc...

First name:Pooja

Last name:Mishra


Country:India


Supervisor:Prof. FörsterInstitute of Immunology

EducationCollege/University:2003-2006 Madurai Kamaraj University, B.Sc., in Zoology.2006-2008 Madurai Kamaraj University, M.Sc., in Genomics.

Highest degree:M.Sc.in Genomics.

Major Subjects:Genomics, Immunology, Molecular Biology, Bioinformatics.

Projects/Research:Investigation of the functional role of IL10R2 in thehematopoietic system and the deficient state being a potential cause of Immune disorder in Inflammatory bowel disease.

Scholarships:1. Awarded a DBT fellowship to work as a Junior Research fellow, 2008.2. Thillayambalam memorial award for the best outgoing studentin zoology, Lady Doak College, 2006.3. JP Samuel endowment award for academic excellence in B.Sc., Lady Doak College, 2003-2006.

Scientific Interests and Goals:I am very glad to begin my research career as a student in Immunology. To deal with the molecular mechanisms of immune disorders ,the immunogenetics behind it and the forward geneticapproach to determine the function of the responsible gene is of great interest to me.In long term, I like to establish myself in theadvancing field of stem cell research and gene therapy. Presentlyfor my Ph.D., I will be studying in detail about the response of various immune cells to the defect in signal transduction due tothe deficiency of IL10R2 in a mouse model.

Hobbies and other interests:Classical dance, music, reading.

First name:Dhaarini

Last name:Murugan


Country:India


Supervisor:Prof.Christoph Klein,Pediatric Hematology and Oncology

EducationCollege/University:2003-2006 Georg-August Universität Göttingen, B.Sc. in Molecular Medicine2006-2008 Georg-August Universität Göttingen, M.Sc. in Molecular Medicine

Highest degree:M.Sc. in Molecular Medicine

Major Subjects:Stem Cell Biology, Hematology, Molecular Oncology

Projects/Research:Only current project here at MHHGeneration of induced pluripotent stem cells with hematopoieticorigin

Scientific Interests and Goals:My major interest is the reprogramming of somatic cells to a pluripotent state. I want to establish the generation of inducedpluripotent stem cells with a hematopoietic origin using different viral vector systems. I am also interested in the (re-)differentiationof these iPS cells to hematopoietic precursors.

Hobbies and other interests:Music, Football, Literature, Travelling…

Publications:Fleige T, Pfaff N, Groß U, Bohne W. (2008): Localisation of gluconeogenesis and tricarboxylic acid (TCA)-cycle enzymes and first functional analysis of the TCA cycle in Toxoplasma gondii. Int J Parasitol. 2008 Aug;38(10):1121-32

First name:Nils

Last name:Pfaff


Country:Germany


Supervisor:Prof. Dr. Thomas MoritzRebirth AG Reprogramming

Education & College/University:1998-2005 medical student, Hannover Medical School (MHH) -clinical electives at the University of Vienna (Austria) and Hiroshima (Japan), final year training at the University of Glasgow and Aberdeen (Scotland)

Highest degree:Physician, Dr. med.

Major Subjects:Tumour biology, cancer susceptibility, clinical genetics

Projects/Research:Investigation of the ETS-transcription factor GABP

Scholarships:Scholarship, Hannover Biomedical Research School (since 2008); doctoral thesis prize for tumour research, Tumour Centre, MHH (2008); scholarship, German National Academic Foundation (2001-2005); grant from the Society of Friends of the MHH (2002)

Scientific Interests and Goals:My main field of interest is tumour biology, especially haematological malignancies. I am interested in genetic and epigenetic networks controlling cellular differentiation and proliferation, as well as aberrations of tumor cells allowing them to overcome cellular control mechanisms. I am investigating the ETS-transcription factor GABP and its function in lymphoid cells. I hope to identify some new target genes and learn more on its potential role in leukaemogenesis, especially in childhood acute lymphoblastic leukaemia.

Publications:Ripperger, T., Gadzicki, D., Meindl, A., Schlegelberger, B.:Breast cancer susceptibility – current knowledge and implications for genetic counselling. Eur J Hum Genet, in press

Ripperger, T., von Neuhoff, N., Kamphues, K., Emura, M., Lehmann, U., Tauscher, M., Schraders, M., Groenen, P., Skawran, B., Rudolph, C., Callet-Bauchu, E., van Krieken, J.H., Schlegelberger, B., Steinemann, D.: Promoter methylation of PARG1, a novel candidate tumor suppressor gene in mantle-cell lymphomas. Haematologica 92 (2007): 460-468.

Rudolph, C., Steinemann D., von Neuhoff, N., Gadzicki, D., Ripperger, T., Drexler H.G., Liehr, T., Claussen, U., Emura, M., Schrock, E., Schlegelberger, B.: Molecular cytogenetic characterization of the mantle cell lymphoma cell line GRANTA-519. Cancer Genet Cytogenet. 153 (2004): 144-50.

First name:Tim

Last name:Ripperger

Date of birth:26 September 1977

Country:Germany


Supervisors:Prof. Schlegelberger and Dr. Steinemann, Institute of Celland Molecular Pathology

EducationCollege/University:2003-2008:Leibniz University, Hannover: Study of Biology

Highest degree:Diploma in Biology (Dipl. Biol.)

Major Subjects:Genetics, Animal physiology, Virology

Projects/Research:

Interactions and motility of HCV structural proteins.

Scientific Interests and Goals:My main field of interest is the cell biology of viral infections.For me it is fascinating to deepen the understanding of the interactions of hosts and pathogens. Apart from this viruses provide a great tool to learn more about cellular processes like transport, signaling or antiviral strategies. Cell biology is another fascinating aspect of my current work I would like to keep at in the future.

Hobbies and other interests:Rowing, Movies, Geographic

First name:Volker

Last name:Rust


Country:Germany


Supervisor:Benno Wölk, MDInstitute of Virology

year 2009

Fareed Ahmad

Mariam Al-omari

Sumadi Lukman Anwar

Mona El Khatib

Stephan Emmrich

Lisa Föhse

Venkateswaran Ganesh

Franziska Greulich

Shashi Kumar Gupta

Christine Happle

Insa Hoffmann

Astrid Kühr

I-Na Lu

Erum Sughra Naqvi

Ramesh Pandey

Ruhi Phaltane

Amit Sharma

Georgios Sogkas

Antoaneta Toncheva

Haiyang Yun

EducationCollege/University:1999-2003, B.Sc. Biological sciences, Yarmouk University, Jordan2003-2006, M.Sc., Biotechnology/immunology, YarmoukUniversity, Jordan


Major Subjects:Molecular Immunology

Projects/Research:Studies on the link between Alpha-1-Antitrypsin deficiency, respiratory viral infection and development of chronic obstructive pulmonary diseases.

Scientific Interests and Goals:My research interests are focused on understanding the underlying biological roles of the alpha-antitrypsin protein (AAT) in lung physiology and pathophysiology. My hope is to add new knowledge that helps in improve the clinical of AAT augmentation therapy.

Hobbies and other interests:Reading, Cooking.

Publications:.l-Al-Qaoud. K, Al-Omari. M, Al-Aghbar. M and S. Abdel-Hafez. 2008. Production of monoclonal antibodies Aagainst the 8 kDaSubunit of Echinococcus granulosus Antigen B (EgAgB8/2) using DNA immunization. Hybridoma (Vol. 27):431-438

First name:Mariam

Last name:Al-Omari


Country:Jordan


Supervisor:Prof. S. Janciauskiene.Pulmonology

EducationCollege/University:1999-2005 Universitas Gadjah Mada, Medical Doctor.2007-2009 Vrije Universiteit Amsterdam, M.Sc in Oncology.

Highest degree:M.Sc. in Oncology

Major Subjects:Oncology

Projects/Research:Profiling of human cancers based on the epigenetic signatures.

Scholarships:1. Fellowship programme in Oncology at the VU Medisch Centrum, Amsterdam organized by the Indonesian and DutchCancer Society, 2006.2. Huygens Scholarship Programme awarded by Nuffic-Nederland organization for international cooperation in highereducation, 2007-2009.

Scientific Interests and Goals:My field of interest is in Oncology. The development of cancers is initiated by a multistep process involving genetic and epigenetic changes. Epigenetic events occur very early in carcinogenesis processes and also drive progression of tumors. Identification of molecular defects causing by epigenetic aberrations will bring into new standpoint of alternative diagnostic, prognostic, and predictive markers and potential therapeutic entities in cancers.

Hobbies and other interests:Photography, traveling, and music.

First name:Sumadi-Lukman

Last name:Anwar


Country:Indonesia


Supervisor:Prof. Ulrich LehmannInstitute of Pathology

EducationCollege/University:2004-2007 American University of Beirut, B.Sc. In Biology2007-2009 American Uiniversity of Beirut, M.Sc in Biology.

Highest degree:M.Sc. in Biology

Major Subjects:Cell and Molecular Biology/Cancer Biology

Projects/Research:Analysis and treatment of the Notch signaling pathway in

hepatocellular carcinoma and cholangiocarcinoma.

Scholarships:Graduate Assistantship from American University of Beirut (2007-2009)

Scientific Interests and Goals:My main field of interest is the intracellular signal transduction pathways especially in cancerous cells. I aspire that my work onthe Notch signaling pathway would contribute to our knowledge on Cancer Therapy.

Hobbies and other interests:Hiking, Reading, Music, Movies, Travel etc...

First name:Mona

Last name:El Khatib


Country:Lebanon


Supervisor:Prof. Ruben PlentzGastroenterology, Hepatology and Endocrinology

EducationCollege/University:2002-2008 University of Rostock, Diploma in Biology2008-2009 University of Rostock, Research Associate

Highest degree:Dipl. Biol.

Major Subjects:MicrobiologyGenetics/Molecular BiologyImmunobiology

Projects/Research:Characterization of chr21-encoded microRNAs in hematopoiesis and AML.1.Identification and functional Investigation of AML signaturemicroRNAs

Scholarships:1.HBRS Scholarship PhD Program ‚Molecular Medicine‘, MH-Hannover, Germany (2009-2010)2.R&D Assistantship from BMFZ, University of Rostock, MedicalSchool, Germany (2008-2009)

Scientific Interests and Goals:My main field of interest is RNA Biology. I am excited by themultitude of mechanisms by which RNAs regulate genes, governmetabolic processes and affect cell fates. I want to study microRNAsand other ncRNAs in leukaemia. My work aims to contribute in progress of understanding and treating childhood AML. Ultimately I want to decipher novel RNA molecules and their mechanisms as players in oncology and development.

Hobbies and other interests:Running, Powerlifting, Movies, Sci-Fi literature, Basketball, Spinning

Publications:Klusmann JH, Li Z, Böhmer K, Maroz A, Koch ML, Emmrich S, Godinho FJ, Orkin SH & Reinhardt D. miR-125b-2 is a potential oncomiR on human chromosome 21 in megakaryoblastic leukemia. Genes Dev. 2010; in press.

Alla V, Engelmann D, Niemetz A, Pahnke J, Schmidt A, Kunz M, Emmrich S, Steder M, Koczan D, Pützer BM. E2F1 in melanoma progression and metastasis. J Natl Cancer Inst. 2010 Jan 20;102(2):127-33.

Emmrich S, Wang W, John K, Li W, Pützer BM. Antisense Gapmers selectivelysuppress individual oncogenic p73 splice isoforms and inhibit tumor growth in vivo. Mol Cancer. 2009 Aug 11;8:61.

First name:Stephan

Last name:Emmrich


Country:Germany


Supervisor:Dr. KlusmannPediatric Hematology & Oncology

EducationCollege/University:2003-2007 University of Applied Sciences Lausitz, B.Sc. in

Biotechnology2007-2009 Hannover Medical School, M.Sc. in Biomedicine

Highest degree:M.Sc. in Biomedicine

Major Subjects:Biomedicine

Projects/Research:Controlling the controllers. Towards the modification of regulatory T cell populations in experimental inflammatory pathologies.

Scholarships:PhD program „Molecular Medicine“

Scientific Interests and Goals:My main field of interest is Immunology. I am fascinated of the organisation and function of the immune system and its defense against pathogens but also its failure.

Hobbies and other interests:Photography, literature, travelling, hiking...

Publications:Karwacki V, Kovac J, Mauceri G, Backhaus A, Föhse L, Schmidtke J, Schubert S.: Tspy is nonfunctional in the Mongolian gerbil but functional in the Syrian hamster. Genomics, 88:65-73, 2006

Haas JD, Gonzalez FH, Schmitz S, Chennupati V, Föhse L, Kremmer E, Förster RJ, Prinz I.: CCR6 and NK1.1 distinguishbetween IL-17A and IFN-gamma-producing gammadelta effectorT cells. Eur J Immunol, 2009

First name:Lisa

Last name:Föhse


Country:Germany


Supervisor:Dr. Immo PrinzInstitute of Immunology

EducationCollege/University:Friedrich-Schiller University of Jena

Highest degree:Dipl. Biochemist

Major Subjects:Biochemistry, Molecular Biology, Molecular Medicine

Projects/Research:The role of T-box transcription factor 18 (Tbx18) in murine heart development at the institute for molecular biology at the MHH.

Scientific Interests and Goals:Every researchers dream is to cure all diseases of the world and to understand nature. Of course, that is also my dream but I realized that is out of my power. So I am concentrating on heart development to understand developmental disorders as well as to learn from nature and maybe sometime I will find the way to heal some of the heart disease or even be able to regenerate a heart (or at least parts of it).

Hobbies and other interests:Cooking, travelling, sports (Volleyball, running especially very early in the morning), reading (due to lack in time: audio book listening)

First name:Franziska

Last name:Greulich

Date of birth:

Country:Germany


Supervisor:Prof. KispertMolecular Biology

EducationCollege/University:2003-2006 Allahabad University, B.Sc. In Botany, Chemistry, Zoology2007-2009 Jawaharlal Nehru University, M.Sc in Life Sciences

Highest degree:M.Sc. In Life Sciences

Projects/Research:Only current project here at MHH1. Micro RNAs as therapuetic targets in cardiac diseases.

Scholarships:1.Junior Research Fellowship (JRF) awarded by Council forScientific and Industrial Research (CSIR), India.2.GATE awarded by IITs.

Scientific Interests and Goals:My main field of interest is MiRNA Biology, I want to use the miRNA as therapuetic target in cadiovascular diseases.

Hobbies and other interests:Music, Cricket, Movies, Chess, etc.

First name:Shashi Kumar

Last name:Gupta


Country:India


Supervisor:Prof. Dr. Thomas Thum

EducationCollege/University:2001-2003 University of Leipzig, Medicine2003-2009 Hannover Medical School, Medicine

Highest degree:Staatsexamen

Major Subjects:

Projects/Research:“Neuroprotection by neuregulin-1 in the setting of systemic inflammation”

Scholarships:HBRS stipend

Scientific Interests and Goals:My current research interest is focused on fetal and neonatal brain development. Our project aims to further enlighten underlying mechanisms leading to preterm birth and perinatal brain damage and to identify potential approaches for preventive strategies. My long term goal is to make a contribution towards disease prevention in the newborn and the developing child, thereby contributing to the improvement of child health.

Hobbies and other interests:Sports (swimming, volleyball), literature etc.

Publications:Hoffmann I, Bueter W, Zscheppang K, Brinkhaus MJ, Liese A, Riemke S, Dörk T, Dammann O, Dammann CEL: Neuregulin-1, the Fetal Endothelium, and Brain Damage in Preterm Newborns (Brain Behavior and Immunity(2009), doi: 10.1016/j.bbi.2009.08.012, in Press) .

First name:Insa

Last name:Hoffmann


Country:Germany


Supervisor:Prof. Dr. Olaf DammannPerinatal Neuroepidemiology

EducationCollege/University:2002-2006 Chang Gung University, B.Sc. In MedicalBiotechnology2006-2008 National Taiwan University, M.Sc in Oral Biology.

Highest degree:M.Sc. in Oral Biology


Projects/Research:DC-SIGN targeted antigen cross-presentation and its role in asthma pathology amelioration

Scholarships:1.Chang Gung University Presidential Award, Taiwan

Scientific Interests and Goals:My main field of research is immunology. Of particular interest isthe role of populations of dendritic cells. These cells have beenimplicated in the maintenance of immune tolerance as well as in thegeneration of immune responses. It is hoped that targeting dendriticcells may be beneficial for a broad range of therapeutic approachesto inflammatory and autoimmune diseases, such as vaccinedevelopment.

First name:I-Na

Last name:Lu


Country:Taiwan


Supervisor:Prof. SparwasserImmunology

EducationCollege/University:2004-2007 University of Delhi, B.Sc. in Microbiology2007-2009 University of Delhi, M.Sc in Biomedical Sciences.

Highest degree:M.Sc. in Biomedical Sciences

Major Subjects:Biochemistry, Cell Biology, Molecular Biology

Projects/Research:1. Identification of specific substrates of SUMOylated components of the MAP kinase cascades and their function in signal transduction.

Scholarships:1. Qualified CSIR-UGC National Eligibility Test (NET) forLecturership (June,2008).2. Qualified CSIR-UGC National Eligibility Test (NET) forJunior Research Fellowship and Lecturership (December,2008).3. Qualified GATE 2009 with an All India Rank 30 (PercentileScore-99.78).

Scientific Interests and Goals:I have a major interest in molecular cell biology, particularly the molecular interactions involved during signal transduction. Further research in this field may lead to better understanding of gene regulation during numerous physiological processes as well as during cancer development.

Hobbies and other interests:Music, Movies, Badminton etc.

First name:Erum Sughra

Last name:Naqvi


Country:India


Supervisor:Prof. NiedenthalPhysiological Chemistry

EducationCollege/University:2000-2005: Pondicherry University, Bachlor of Veterinary Science 2007-2009: I I T Chennai, M.S. (by research) in Biotechnology.

Highest degree:M.S. (by research) in Biotechnology

Major Subjects:Veterinary Medicine, Biotechnology, Immunology, Functional genomics

Projects/Research:1. "A systematic and functional analysis of genetic variants in TLRpathways and their effect on asthma and allergy development".

Scholarships:1.All India Rank 08 and qualified for Junior Research Fellow (JRF) by Indian council of Agriculture research (2007)2.Qualified in GATE conducted by Indian Institute of Technology Kanpur, Percentile score – 98.33% (2007)3.Qualified for JRF/LS by CSIR-UGC, Govt of India (2008)

Scientific Interests and Goals:My research interest is in endeavour to understand biologicalprocesses by multidisciplinary approach. Currently, I am interestedin understanding the role of genetics variants in TLR pathways in relation to asthma and allergy.

Hobbies and other interests:Music, Table Tennis, Art and Science etc.

Publications:Ramesh Chandra Pandey, Debduti Datta, Ruma Mukerjee, AlagarsamySrinivasan, Sundarasamy Mahalingam, and Bassel E. Sawaya; ‘HIV-1 Vpr: a closer look at the multifunctional protein from the structural perspective’. Current HIV Research, 2009, Vol 7, Pp. 114-128.

First name:Ramesh

Middle name:Chandra

Last name:Pandey


Country:India


Supervisor:Prof. Dr. Michael KabeschDept. of Paediatric Pneumology and Neonatology

EducationCollege/University:2003-2006 Vidya Pratisthan‘s School of Biotechnology, Baramati(Pune University affiliation), BSc Biotechnology2006-2008 Vidya Pratisthan‘s School of Biotechnology, Baramati(Pune University affiliation), MSc Biotechnology



Projects/Research:1.Standardization of total RNA extraction method from Syzygiumcumini leaves for mRNA purification and RT-PCR.2. Multisite monitoring of human influenza in India3. Diagnosis and whole genome sequencing of the Novel A (H1N1) 2009 Influenza virus.

Scientific Interests and Goals:My main interest is gene therapy in Hematopoietic Stem Cells (HSCs). For successful gene therapy it is very necessary that the cells with corrected gene get incorporated in the immune system as well as it has minimum side effects. Thus my aim is to assessthe genotoxicity of various viral vectors in context to hematopoietic gene therapy and in vivo selection. With this research it would help to better define the risk profile of novel strategies of gene insertion and influence the future development of hematopoietic gene therapy.

Hobbies and other interests:Music, Badminton Movies, Observing nature etc.

First name:Ruhi

Last name:Phaltane


Country:India


Supervisors:Prof Dr. Thomas MoritzREBIRTHDr. Ute ModlichDept. Expt. Hematology

EducationCollege/ University:2004 – 2006 Faculty of Biology, Sofia University „St. KlimentOchridski“ and Dpartment of Medical Genetics, MedicalUniversity – Sofia, M. Sc. in Molecular Biology – Genetics2001 – 2004 Faculty of Biology, Sofia University „St. KlimentOchridski“, B. Sc. in Molecular Biology2000 – 2001 Faculty of Biology, Sofia University „St. KlimentOchridski“, Speciality „Biology and chemistry“

Highest degree:M.Sc. in Molecular Biology – Genetics

Major Subjects:Genetics, Molecular biology, Biochemistry

Projects/Research:The role of genetic variants in the chromosome 17q21 locus in childhood asthma

Scientific Interests and Goals:The main field of mine interest is Human Molecular Genetics. I want to go deeper in the area of the accosiation studies for geneticpredispozition to multifactor-based diseases. Asthma is one of them. I would be satisfied as a young scientistc if i am able to improve the knowledge that will help us to understand this area of genetics better.

Hobbies and other interests:traveling, summer holiday in the mountain, reading books, swimming, foreign languages, photography, theatre, music

First name:Antoaneta

Last name:Toncheva


Country:Bulgaria

e-mail:[email protected]

Supervisor:Prof. Dr. Michael KabeschDept. of PaediatricPneumology and Neonatology

EducationCollege/University:2000-2005 Tongji University, Bachelor in Medicine2005-2008 Shanghai Jiao Tong University, Master in Medicine

Highest Degree:Master in Medicine

Major Subjects:Internal Medicine (Hematology and Oncology)

Projects/Research:1. The role of Mll5 in leukemia stem cell self renewal and differentiation2. Functional validation and in vivo targeting of a high-risk gene signature in AML

Scholarships:1. First-Class Postgraduate Scholarship, Shanghai Jiao Tong University, China (2006/2008)2. Excellent University Graduate Award, Shanghai Municipal Education Commission, China (2005)3. Excellent Student Scholarship, Tongji University, China (2001/2002/2003/2004)

Scientific Interests and Goals:Experimental Hematology (leukemogenesis and therapeutics in AML), Cancer Stem Cell Biology, Molecular Biology, MolecularGenetics and Epigenetics.

Hobbies and Other Interests:Jogging, Travel, Basketball, Movies, Music

Publications:1. Damm F, Heuser M, Morgen M, Yun H, Schlegelberger B, Döhner K, Ottmann O, Lübbert M, Heit W, Kanz L, Schlimok G, Raghavachar A, Fiedler W, Kirchner H, Döhner H, Heil G, Ganser A, Krauter J. Journal of Clinical Oncology (In press). A single nucleotide polymorphism in the mutationalhotspot of WT1 predicts a highly favorable outcome in cytogenetically normal acute myeloid leukemia patients. 2. Pan Q, Zhu YJ, Gu BW, Cai X, Bai XT, Yun HY, HY, Zhu J, Chen B, Weng L, Chen Z, Xue YQ, Chen SJ. Oncogene (2008) 27, 3414-3423. A newfusion gene NUP98-IQCG identified in an acute T lymphoid/myeloid leukemiawith t(3;11)(q29q13;p15)del(3)(q29) translocation. 3. Yun HY, Chen SJ. International Journal of Genetics (In Chinese) 2008 31 (01). General review of the structural and functional research on IQ motif as to regulate calcium.

First name:Haiyang

Last name:Yun


Country:P.R.China


Supervisor:Dr. Michael HeuserDept. Hematology, Hemostaseology, Oncology and Stem Cell Transplantation

Faculty Jürgen Alves Ulrich Martin Christopher Baum Ulrich Maus Georg Behrens Eva Medina Jens Bohne Fritz Melchers Jürgen Borlak Martin Messerle Armin Braun (Fraunhofer Institute) Nils v. Neuhoff Anna-Maria Dittrich Heiner Niemann (TiHo, Mariensee) Matthias Eder Ruben Plentz Britta Eiz-Vesper Stefan Poehlmann Reinhold Förster Ulrike Raap Matthias Gaestel Francoise Routier Harald Genth Lenhard Rudolph (now Ulm) Engelbert Gessner Martin Sauer Achim Gossler Axel Schambach Karsten Grote Michaela Scherr Matthias Gunzer (prev. HZI) Bernhard Schieffer Carlos Alberto Guzmann (HZI) Brigitte Schlegelberger Hermann Haller Reinhold Ernst Schmidt Hansjörg Hauser (HZI) Jörg Schmidtke Denise Hilfiker Thomas F. Schulz Helmut Holtmann Reinhard Schwinzer Roland Jacobs Ursula Seidler Elmar Jaeckel Axel Seltsam Christine Josenhans Beate Sodeik Ingo Just Tim Sparwasser Andreas Kispert Renata Stripecke Christoph Klein Manfred Stuhrmann-Spangenberg Andreas Klos Sebastian Suerbaum Hannes Klump Gregor Theilmeier Alexey Kotlyarov Burkhard Tümmler Hans Kreipe Ernst Ungewickell Norbert Krug (Fraunhofer Institute) Claus Urbanke Ulrich Lehmann Jürgen Wehland (HZI) Zhixiong Li Siegfried Weiss (HZI) Robert Lindner Eva Weissinger Nisar Peter Malek Karl H. Welte Dietmar Manstein Thomas Werfel

Department and function:Professor, Biophysical Chemistry

Education:1975 – 1981 University of Hannover, Biochemistry1981 – 1984 PhD thesis

Positions:1984 – 1990 Postdoc Hannover Medical School1990 – 1995 PD Hannover Medical School1995 - Prof. Hannover Medical School

Major research interests:Protein design using different model systems:• Restriction endonuclease EcoRI• IS1 Transposase• Helikase I• DynaminCircular Dichroism Spectroscopy

Selected Publications:Kalthoff C, Alves J, Urbanke C, Knorr R, Ungewickell EJ. J Biol Chem 2002, 277: 8209-16.Scheele U, Alves J, Frank R, Duwel M, Kalthoff C, Ungewickell E. J Biol Chem. 2003; 278(28):25357-68.Fritsche P, Alves J. Biol Chem. 2004; 385(10):975-85Wierstra I, Alves J. Biochem Biophys Res Commun. 2006 Sep 15;348(1):99-108.Wierstra I, Alves J. Biol Chem. 2006 Jul;387(7):949-62. Wierstra I, Alves J. Biol Chem. 2006 Jul;387(7):963-76.Wierstra I, Alves J. FEBS J. 2006 Oct;273(20):4645-67Wierstra I, Alves J. Biochem Biophys Res Commun. 2007;352(1):61-8.Wierstra I, Alves J. Biol Chem. 2007;388(8):805-18Wierstra I, Alves J. Biochem Biophys Res Commun. 2008;368(1):107-15.

First name:Jürgen

Last name:Alves

Acad. Title:Prof. Dr. rer. nat.

Address:OE 4350Hannover Medical School

Phone and e-mail:++49-0511-532 [email protected]

Further information:http://www.bpc.mh-hannover.de/

Department and function:Professor, Experimental Hematology

Education:1981-1982 Philosophy1982-1989 Medicine

Positions:1989-1991 Research Clinics, Borstel b. Bad Oldesloe1991-1992 Toxicology, Univ. of Hamburg1993-1999 Heinrich-Pette-Institute Hamburg 2000 University Hospital Eppendorf, Hamburg2000 - MHH, Dept. Hematology and Oncology2002 - Cincinnati Children‘s Hospital Adjunct Position2006 - Head of Experimental Hematology

Major research interests:Cell Therapy, Gene Transfer and TherapyRetroviruses, Gene expressionStem Cell BiologyBiology of cell selection and clonal evolution

Oncogenesis

Selected Publications:Williams D, Baum C Nature. 2004; 429(6988):129Frank O, et al. Blood. 2004; 104(12):3543-9.von Kalle C, et al. Semin Hematol. 2004; 41(4):303-18.Modlich U, et al. Blood. 2005; 105(11):4235-46.Kustikova O, et al. Science. 2005; 308(5725):1171-4.Klump H, et al. Ann N Y Acad Sci. 2005; 1044:6-15.Schambach A, et al. Mol Ther. 2006 Feb;13(2):391-400.Schambach A, et al. Gene Ther. 2006; Apr;13(7):641-5Schambach A, et al. Gene Ther. 2006 Jul;13(13):1037-47Schambach A, et al. Exp Hematol. 2006 May;34(5):588-92.Modlich U, et al. Blood. 2006 Oct 15;108(8):2545-53.Kraunus J, et al. J Biol Chem. 2006 Dec 8;281(49):37381-90Kustikova OS, et al. Blood. 2007 Mar 1;109(5):1897-907.Li Z, et al. Ann N Y Acad Sci. 2007 Jun;1106:95-113. Schambach A, et al. Mol Ther. 2007 Jun;15(6):1167-73. Meyer J, et al. Leukemia. 2007 Oct;21(10):2171-80. Thornhill SI, et al. Mol Ther. 2008 Mar;16(3):590-8.Galla M, et al. J Virol. 2008 Mar;82(6):3069-77Zychlinski D, et al. Mol Ther. 2008;16(4):718-25.Modlich U, et al.Leukemia. 2008;22(8):1519-28.Li Z, et al. Blood. 2008 Dec 4. [Epub ahead of print]

First name:Christopher

Last name:Baum

Acad. Title:Prof. Dr. med.Prof. of Pediatrics



Further information:http://www.eh.mh-hannover.de/

Department and function:Clinic for Immunology and Rhematology, Juniorprofessor

Education:1996 Doktoral Thesis (Dr. med.), University of Giessen2007 Habilitation in Immunology, MHH

Positions:19996-2001: Internship in the Division of Clinical Immunology,

Department for Internal Medicine, MHH2001-2003: DFG-Postdoc/Research Officier, Walter and Eliza Hall

Institut, Melbourne; aUSTRALIA2003: Juniorprofessor for T Cell Immunology, Clinic for

Immunology and Rheumatology

Major research interests:Function of dendritic cellsAdaptive immunity to viral infectionToleranceHIV-pathogenesis, -therapy and treatment-associated side effects

Selected Publications:Bux J, Behrens G, Jaeger G, Welte K (1998). Blood 91:181-186.Behrens G, Schmidt H, Meyer D, Stoll M, Schmidt RE (1998). Lancet 351:1958Belz GT, Behrens GMN, Smith CM, Miller JFAP, Jones C, Lejon K, Garrison Fathman C, Mueller SN, Shortman K, Carbone FR, Heath WR (2002). J Exp Med. 196:1099-1104. Behrens GMN, Boerner A-R, Weber K, v d Hoff J, Ockenga J, Brabant G, Schmidt RE (2002). J Clin Invest. 110:1319-1327.Behrens GMN, Li M, Davey G, Allison J, Flavell R, Carbone FR, Heath WR (2004). J Immunol. 172:5420-5426.Wilson NS*, Behrens GMN*, Lundie RJ*, Smith CM, Waithmann J, Young L, Forehan SP, Mount A, Steptoe RJ, Shortman KD, de Koning-Ward TF, Belz GT, Carbone FR, Crabb BS, Heath WR, Villadangos JA (2006). Nat Immunol. 7:165-172. Schnorrer P*, Behrens GMN*, Wilson NS*, Pooley JL, Smith CM, El-Sukkari D, Davey G, Kupresanin F, Li M, Belz GT, Maraskovsky E, Belz GT, Carbone FR, Shortman KD, Heath WR, Villadangos JA (2006) Proc Natl Acad Sci USA 103:10729-34Stankov M, Schmidt RE, Behrens GMN (2007). Antivir Ther 2007; 12: 205-216Stankov MV, Schmidt RE, Behrens GM; German Competence Network HIV/AIDS. Antimicrob Agents Chemother. 2008;52(8):2882-9.Hartwig C, Constabel H, Neumann D, Gerd Hoymann H, Tschernig T, Behrens GM. Exp Toxicol Pathol. 2008;60(6):425-34. Jirmo AC, Nagel CH, Bohnen C, Sodeik B, Behrens GM.J Immunol. 2009; 182(1):283-92.

First name:Georg

Last name:Behrens

Acad. Title:Prof. Dr.


Phone and e-mail:++49- 511- 532 [email protected]

Further information:http://www.mh-hannover.de/klinimm.html

Department and function:Institute for Virology; Group leader (Cell & Virus Genetics)

Education:2002 PhD in Biology (Virology), University Heidelberg

Positions:2003-2006: Postdoc at the department of Experimental Hematology

(MHH), Co-leader of the vector team2007-recent: Group leader at the Institute for Virology

Major research interests:Retroviral gene expression on the RNA levelMutations in cellular genes, which affect RNA processingRNA expression in complex DNA viruses

Selected Publications:

Bohne J*, Schambach A, Zychlinski D. A new way of regulating alternative splicing in retroviruses: the promoter makes a difference. Journal of Virology. 2007 Apr 1;81(7):3652-6. Epub 2007 Jan 17. *Corresponding author.

Kraunus J, Zychlinski D, Heise T, Galla M, Bohne J*, Baum C*. Murine leukemiavirus regulates alternative splicing through sequences upstream of the 5’ splice site. Journal of Biological Chemistry. 2006 Dec 8; 281 (49):3 ;281(49):37381-90. Epub 2006 Oct 11. *Co-corresponding authors.

Modlich U*, Bohne J*, Schmidt M, v. Kalle C, Knöß S, Schambach A, Baum C. New cell culture assays reveal reduced insertional genotoxicity of self-inactivating retroviral vectors. Blood. 2006 Oct 15;108(8):2545-53. Epub 2006 Jul 6. *Joint first author.

Schambach A, Mueller D, Galla M, Verstegen M, Wagemaker G, Baum C, Bohne J. Overcoming promoter competition in packaging cells improves production of self-inactivating retroviral vectors. Gene Therapy. 2006 Nov;13(21):1524-33. Epub 2006 Jun 8.

Bohne J, Wodrich H, Kräusslich HG. Splicing of human immunodeficiency virus RNA is position-dependent suggesting sequential removal of introns from the 5’ end. Nucleic Acid Research. 2005 Feb 8;33(3):825-37

First name:Jens

Last name:Bohne

Acad. Title:Dr.


Phone and e-mail:++49- 511-532 [email protected]

Department and function:Director Fraunhofer ITEM and Chair in Pharmaco- and Toxicogenomics at the Medical School of Hannover

Education:1989 Ph.D. in biochemistry and biochemical toxicology2000 Habilitation (Pharmacology and Toxicology), Medical School of Hannover, Germany

Positions:2002-recent: Chair in Pharmaco- and Toxicogenomics, Medical

School of Hannover, Germany1989-recent: Departmenthead, Molecular Medicine and Medical

Biotechnology, Fraunhofer Institute of Toxicology and Experimental Medicine (ITEM), Hannover, Germany

1992-1998 Sectionhead - Preclinical Research - Pharmaceutical Industry, Germany

1990-1992 Senior Research Biochemist and Head, Unit of Pharmacogenetics, Marion Merrell Dow Research Centre, Strasbourg, France

1989 – 1990: Cancer Research Campaign funded Postdoctoral Research Fellow and Project Director, Molecular Oncology Group, University of Reading, UK

Major research interests:Molecular effects of drugs and xenobiotics, using a wide range of methods and technologies in cell biology, genomics and molecularbiologyMolecular toxicology of novel therapeuticsMolecular imaging using µCT, PET and optical imaging. Use of NIR fluorescent dyes for optical imaging of cell based therapies and of INPs in vivo. Identification of markers to image dysplasia.Novel strategies for safety studies on rebirth therapies

Selected Publications:Falck, C. v., Rodt, T., Halter, R., Spanel, R., Galanski, M and Borlak, J (2009) Frontiers in Bioscience. 14:2193-2202.Rodt, T., Falck, C. v., Halter, R., Ringe, K., Shin, H.O., Galanski, M. and Borlak, J. (2009) Frontiers in Bioscience. 14:1939-1944.

First name:Jürgen

Last name:Borlak


Address:Fraunhofer ITEM& OE 9646Hannover Medical School


Further information:http://www.item.fraunhofer.de

Department and function:Head of Immunology and Allergology, Fraunhofer Institute of Toxicology and Experimental Medicine

Education:1998 PhD in Immunology, Humboldt-University

Berlin

Positions:1999-2001 Scientific Assistant (“post doc”), Prof. Dr. Renz,

Department of Clinical Chemistry, Philipps University Marburg, Germany

2001- Head of Immunology and Allergology, FraunhoferInstitute of Toxicology and Experimental Medicine

Major research interests:Neuro-immun Interaction in asthma; Animal models of asthmaLung infection models; Immunotoxicology

Selected Publications:A. Braun, M. Lommatzsch, U. Neuhaus-Steinmetz, D. Quarcoo, H. Renz. Br J Pharmacol. 2004;141:431-440H. Weigt, P.F. Muhlradt, M. Larbig, N. Krug, A. Braun. J Immunol. 2004; 172(10):6080-6.R. Bälder, B. Fuchs, W. Bautsch, J. Zwirner, et al. J. Immunol. 2005; 174(2):783-9.Schulte-Herbruggen O, Nassenstein C, Lommatzsch M, Quarcoo D, Renz H, Braun A. J Neuroimmunol. 2005;160(1-2):204-9Weigt H, Nassenstein C, Tschernig T, Muhlradt PF, Krug N, Braun A. Am J RespirCrit Care Med. 2005;172(5):566-72.Lommatzsch M, Quarcoo D, Schulte-Herbruggen O, Weber H, Virchow JC, Renz H, Braun A. Int J Dev Neurosci. 2005;23(6):495-500.Nassenstein C, Schulte-Herbruggen O, Renz H, Braun A. Eur J Pharmacol. 2006; 533(1-3):195-206. Nassenstein C, Dawbarn D, Pollock K, Allen SJ, Erpenbeck VJ, Spies E, et al. J Allergy Clin Immunol. 2006;118(3):597-605Nassenstein C, Kammertoens T, Veres TZ, Uckert W, Spies E, Fuchs B, et al. J Allergy Clin Immunol. 2007;120(5):1089-96.Veres TZ, Rochlitzer S, Shevchenko M, Fuchs B, Prenzler F, Nassenstein C,et al. Am J Respir Cell Mol Biol. 2007;37(5):553-61.Henjakovic M, Sewald K, Switalla S, Kaiser D, Müller M, Veres TZ, Martin C, UhligS, Krug N, Braun A. Toxicol Appl Pharmacol. 2008;231(1):68-76. Henjakovic M, Martin C, Hoymann HG, Sewald K, Ressmeyer AR, Dassow C, Pohlmann G, Krug N, Uhlig S, Braun A. Toxicol Sci. 2008;106(2):444-53. Veres TZ, Shevchenko M, Krasteva G, Spies E, Prenzler F, Rochlitzer S, TschernigT, Krug N, Kummer W, Braun A. Am J Pathol. 2009;174(3):808-17.

First name:Armin

Last name:Braun

Acad. Title:PD Dr.

Address:Nikolai-Fuchs-Str. 130625 Hannover

Phone and e-mail:+49 511 5350 [email protected]

Further information:www.item.fraunhofer.de

Department and function:Junior Research Group Leader within the collaborative research center„immune responses of the lung in infection and allergy“

Education:1994-2001 Medical studies, Humboldt University Berlin2002 Medical Doctorate, Humboldt University Berlin

Positions:2002-2005: Residency Department for Pediatric Pneumology and

Immunology, Charité, University Medicine Berlin2005-2007: Postdoctoral Fellowship, Laboratory of Prof. Kim

Bottomly, Department for Immunobiology, Yale University School of Medicine, New Haven, CT, USA

Since 08/2007: Junior Research Group Leader, Collaborative Research

Center 587 “Immune Reactions of the Lung in Infection and Allergy”

Major research interests:Understanding the immunological mechanisms that underlie allergic sensitization with a focus on T cells and their mediators

Selected Publications:Hutloff, A., A.M. Dittrich, K.C. Beier, B. Eljaschewitsch, R. Kraft I. Nature 1999; 397:263-266.Beier, K.C., A. Hutloff, A.M. Dittrich, C. Heuck, A. Rauch, K. Büchner, B. Ludewig, H.D. Ochs, H.W. Mages, R.A. Kroczek. Eur. J. Immunol. 2000 30:3707-3717Dittrich A.M., Bunk R., Schulze I., Horn J., Schmolke K., Volk H.D., Wahn V., Hoflich C. Int Arch Allergy Immunol. 2006; 140:342-4Dittrich A.M., Erbacher A., Specht S., Diesner F., Krokowski M., Avagyan A., Stock P., Ahrens B., Hoffmann W.H., Hoerauf A., Hamelmann E. J Immunol 2008; 180: 1792-1799.Dittrich AM, Chen HC, Xu L, Ranney P, Connolly S, Yarovinsky TO, Bottomly HK.J Immunol. 2008;181(10):7307-15.

First name:Anna-Maria

Last name:Dittrich

Acad. Title:Dr.

Address:OE 9431.1Hannover Medical School


Further information:http://www.mh-hannover.de/nwg.html

Department and function:Professor, Hematology/Oncology unit; Consultant Bone marrow transplantation

Education:1982-89 Study of Medicine, Homburg/S and

Frankfurt/M1990 Doctoral thesis1989-91 Research assistant and fellow Int. Med.1991-93 Research fellow Dana Farber Cancer Inst., Boston1993-2000 Research fellow Int. Med. Frankfurt + MHHSince 2001 Habilitation, consultant Int. Medicine

Positions:1991-1993 Dana Farber Cancer Institute, Boston1993-1996 Johann Wolfgang v.Goethe University

FrankfurtSince 1996 MHH

Major research interests:Signal transduction by cytokine receptors in myeloid cellsModels for myeloproliferative disorders and acuteleukemiaLentiviral gene transferRNA interference

Selected Publications:Scherr M, Steinmann D, Eder M. Ann Hematol. 2004; 83(1):1-8.Scherr M, Eder M. Curr Opin Mol Ther. 2004; 6(2):129-35Scherr M, Battmer K, Schultheis B, Ganser A, Eder M. Gene Ther. 2005; 12:12-21.Eder M, Scherr M. N Engl J Med. 2005; 352(23):2446-8.Scherr M, Chaturvedi A, Battmer K, Dallmann I, Schultheis B, Ganser A, Eder M. Blood. 2006;107(8):3279-87.Venturini L, Battmer K, Castoldi M, Schultheis B, Hochhaus A, Muckenthaler MU, Ganser A, Eder M, Scherr M. Blood. 2007;109(10):4399-405.Chaturvedi A, Battmer K, Schaefer D, Ganser A, Eder M, Scherr M. Oligonucleotides. 2007 Spring;17(1):22-34.Scherr M, Venturini L, Battmer K, Schaller-Schoenitz M, Schaefer D, Dallmann I, Ganser A, Eder M. Nucleic Acids Res. 2007;35(22):e149. Epub 2007 Nov 19.Buchholz S, Dammann E, Koenecke Ch, Stadler M, Franzke A, Blasczyk R, Bremer M, Krauter J, Hertenstein B, Ganser A, Eder M. Ann Hematol. 2008;87(7):551-6.Scherr M, Venturini L, Eder M. Methods Mol Biol. 2009;506:207-19.

First name:Matthias

Last name:Eder

Acad. Title:Prof. Dr. med.



Further information:http://www.mh-hannover.de/250.html

Department and function:Professor, Institute for Transfusion Medicine

Education:1988 – 1993 Biology, University Greifswald1993 – 1996 PhD, Virology, MHH2003 W1-Professor for Immunogenetics, Institute for

Transfusion Medicine, MHH

Positions:1996-1999 Research Group Leader at the German Red Cross

Institute, Springe1999-2003 Research Group Leader, Institute for Transfusion

Medicine, MHH2003-recent W1-Professor for Immunogenetics, Institute for

Transfusion Medicine, MHH

Major research interests:• Minor histocompatibility antigens involved in GvL and GvHD• Antigen-specific cytotoxic T cells• Cell therapy• Expression of recombinant HLAs and proteins• Peptide sequencing

Selected Publications:Eiz-Vesper B, Seltsam A, Blasczyk R. Transfusion 2005; 45 (6): 960-968.Eiz-Vesper B, Horn PA, Daubert C, Khattab B, Blasczyk R. Transfusion 2006;

46(7):1210-20.Bade-Doeding C, Deluca DS, Seltsam A, Blasczyk R, Eiz-Vesper B. Immunogenetics

2007;59(4):253-9Eiz-Vesper B, Blasczyk R, Horn PA. Immunogenetics. 2007;59(6):507-10.Eiz-Vesper B, Deluca DS, Blasczyk R, Horn PA. Tissue Antigens. 2007;70(2):164-8.Eiz-Vesper B, Blasczyk R, Horn PA. Tissue Antigens. 2007;70(1):71-2 Paine A, Oelke M, Blasczyk R, Eiz-Vesper B. Transfusion. 2007;47(11):2143-52. Wang D, Drenker M, Eiz-Vesper B, Werfel T, Wittmann M. Evidence for a

pathogenetic role of interleukin-18 in cutaneous lupus erythematosus. Arthritis Rheum. 2008 Oct;58(10):3205-15.

Figueiredo C, Wittmann M, Wang D, Dressel R, Seltsam A, Blasczyk R, Eiz-VesperB. Heat shock protein 70 (HSP70) induces cytotoxicity of T-helper cells.Blood. 2008 Nov 18. [Epub ahead of print]

Hinrichs J, Figueiredo C, Hirv K, Mytilineos J, Blasczyk R, Horn PA, Eiz-Vesper B. Discrimination of HLA null and low expression alleles by cytokine-inducedsecretion of recombinant soluble HLA. Mol Immunol. 2009 Feb 3. [Epubahead of print]

First name:Britta

Last name:Eiz-Vesper


Address:OE 8355Institute for Transfusion MedicineHannover Medical School


Further information:http://www99.mh-hannover.de/institute/transfusion/transfusionsmedizin/

Department and function:Director, Immunology

Education:1981 Abitur, Gymnasium Pegnitz1988 DVM, Munich, Veterinary Faculty1988 - 1991 Ph.D. Thesis

Positions:1991-93 Postdoc, Insitute of Biochemistry, University of Munich1994-00 Research Associate, Max-Delbruck-Center for

Molecular Medicine, Berlin2000-01 Associate Professor for Experimental Surgery and

Immunology, University of Erlangen2001 – Director and Head, Institute of Imunology, Professor for

Immunology

Major research interests:Chemokines and chemokine receptors, role in lymphoid organorganogenesis and organization, development of immunology memory,cell migration, tumor metastasis

Selected Publications:Hintzen G, Ohl L, del Rio ML, Rodriguez-Barbosa JI, Pabst O, Kocks JR, Krege J, Hardtke S, Forster R. J Immunol. 2006 Nov 15;177(10):7346-54.Berberich S, Forster R, Pabst O. Blood. 2007 Feb 8; [Epub ahead of print] Davalos-Misslitz AC, Rieckenberg J, Willenzon S, Worbs T, Kremmer E, Bernhardt G, Forster R. Eur J Immunol. 2007; 37(3):613-22. Worbs T, Mempel TR, Bölter J, von Andrian UH, Förster R. J Exp Med. 2007;204(3):489-95. Epub 2007 Feb 26.Kocks JR, Davalos-Misslitz AC, Hintzen G, Ohl L, Förster R. J Exp Med. 2007;204(4):723-34. Epub 2007 Mar 19. Wendland M, Czeloth N, Mach N, Malissen B, Kremmer E, Pabst O, Förster R. ProcNatl Acad Sci U S A. 2007 Apr 10;104(15):6347-52. del Rio ML, Rodriguez-Barbosa JI, Kremmer E, Förster R. J Immunol. 2007;178(11):6861-6. Kahlmann D, Davalos-Misslitz AC, Ohl L, Stanke F, Witte T, Förster R. BMC Genet. 2007 Jun 22;8:33. Davalos-Misslitz AC, Worbs T, Willenzon S, Bernhardt G, Förster R. Blood. 2007;110(13):4351-9.Czeloth N, Schippers A, Wagner N, Müller W, Küster B, Bernhardt G, Förster R. J Immunol. 2007;179(9):5855-63. del Rio ML, Rodriguez-Barbosa JI, Bölter J, Ballmaier M, Dittrich-Breiholz O, Kracht M, Jung S, Förster R. J Immunol. 2008 Nov 1;181(9):6178-88.Koenecke C, Förster R. Expert Opin Ther Targets. 2009 Mar;13(3):297-306.

First name:Reinhold

Last name:Förster

Acad. Title:Prof. Dr. med. vet

Address:OE5240Hannover Medical School

Phone and e-mail:[email protected]

Department and function:Director, Biochemistry (Physiological Chemistry)

Education:1983 PhD in Biology (Biophysics), Humboldt-University

Berlin1993 Habilitation in Biochemistry, Free University Berlin

Positions:1991-1995: Junior Research Group Leader at the Max-Delbrück-

Centrum for Molecular Medicine (MDC), Berlin-Buch1995-1997: Heisenberg-Fellow of the German Research Council

(DFG), Guest Research Group Leader at the MDC,Berlin-Buch

1997-2000: Professor of Molecular Genetics; Innovationskolleg"Zellspezialisierung" of the Martin-Luther-UniversityHalle-Wittenberg

2001-recent: Chair and Head of Institute of Biochemistry/ Physiological Chemistry of Hannover Medical School

Major research interests:Analysis of mechanisms of stress-dependent signal transductionNucleo-cytoplasmic signallingRegulation of gene expression by protein phosphorylation at the post-transcriptional level

Selected Publications:Schumacher S, Laass K, Kant S, Shi Y, Visel A, Gruber AD, Kotlyarov A, Gaestel M EMBO J. 2004; 23(24):4770-4779Gaestel M. Nat Rev Mol Cell Biol. 2006; 7(2):120-30.Hitti E, Iakovleva T, Brook M, Deppenmeier S, Gruber AD, Radzioch D, Clark AR, Blackshear PJ, Kotlyarov A, Gaestel M. Mol Cell Biol. 2006;26(6):2399-407.Vertii A, Hakim C, Kotlyarov A, Gaestel M. J Biol Chem. 2006;281(37):26966-75Kant S, Schumacher S, Singh MK, Kispert A, Kotlyarov A, Gaestel M. J Biol Chem. 2006;281(46):35511-9.Jakobs A, Koehnke J, Himstedt F, Funk M, Korn B, Gaestel M, Niedenthal R. Nat Methods. 2007 Mar;4(3):245-50.Jakobs A, Himstedt F, Funk M, Korn B, Gaestel M, Niedenthal R. Nucleic Acids Res. 2007;35(17):e109.Zaru R, Ronkina N, Gaestel M, Arthur JS, Watts C. Nat Immunol. 2007;8(11):1227-35.Thomas T, Timmer M, Cesnulevicius K, Hitti E, Kotlyarov A, Gaestel M. J Neurochem. 2008;105(5):2039-52Thomas T, Hitti E, Kotlyarov A, Potschka H, Gaestel M. Eur J Neurosci. 2008; 28(4):642-54.Zimnik S, Gaestel M, Niedenthal R. Nucleic Acids Res. 2009 Jan 27. [Epub ahead of print]

First name:Matthias

Last name:Gaestel





Department and function:Group leader, Department of Toxicology

Education:1998-95 Chemistry, Technical University of Darmstadt,

Germany 1995-2000 PhD in Chemistry, Albert-Ludwigs-Universität

Freiburg

Positions:2000-recent: Group leader, Institute of Toxicology/

Hannover Medical School

Major research interests:Mode of action of bacterial protein toxinsSignal transduction pathways governed by Rho and Ras

Selected Publications:Genth, H., J. Selzer, C. Busch, J. Dumbach, F. Hofmann, K. Aktories, I. Just.. Infection and Immunity. 2000; 68: 1094-1101Genth, H., R. Gerhard, A. Maeda, M. Amano, K. Kaibuchi, K. Aktories, I. Just.. Journal of Biological Chemistry. 2003; 278:28523-28527.Gerhard,R., H. Tatge, H. Genth, T. Thum, J. Borlak, G. Fritz, I. Just.. Journal of Biological Chemistry 2005; 280(2):1499-505, 2005.Czeloth, N., G. Bernhardt, F. Hofmann, H. Genth, R. Foerster. Journal of Immunology 2005; 175(5):2960-7.Genth H, Huelsenbeck J, Hartmann B, Hofmann F, Just I, Gerhard R. FEBS Lett. 2006;580(14):3565-9Huelsenbeck J, Dreger S, Gerhard R, Barth H, Just I, Genth H. Infect Immun. 2007; 75(2):801-9.Huelsenbeck J, Dreger SC, Gerhard R, Fritz G, Just I, Genth H. Biochemistry. 2007 Apr 24;46(16):4923-31Halabi-Cabezon I, Huelsenbeck J, May M, Ladwein M, Rottner K, Just I, Genth H. FEBS Lett. 2008 Nov 12;582(27):3751-6.Dreger SC, Schulz F, Huelsenbeck J, Gerhard R, Hofmann F, Just I, Genth H. Biochemistry. 2009 Feb 6. [Epub ahead of print]

First name:Harald

Last name:Genth

Acad. Title:Dr. rer. nat.



Further information:http://www.mh-hannover.de/toxicology.html?&no_cache=1

Department and function:Group Leader, Laboratory of Molecular Immunology; ClinicalImmunology

Education:1993 PhD in Chemistry and Molecular Biology, Technical

University (TU) Berlin1999 Habilitation in Immunology, Hannover Medical School

Positions:1994-1996: Research Associate, Dept. of Clinical Immunology,

Hannover Medical School 1994: Visiting Scientist, Dept. of Immunology, University of

Utrecht, The Netherlands1997: EMBO Research Fellow, Dept. of Pathology, CMU

Geneva, Switzerland1997-recent: Research Group Leader, and from 2002 on, Scientific

Director and Head of the Laboratory of Molecular Immunology at the Department of Clinical Immunology, Hannover Medical School

Major research interests:I) Analysis of molecular mechanisms underlying immunoregulationduring disease development in gene knockout mice.II) Signal transduction of G-protein coupled receptors.III) Gene regulation of IgG Fc receptors and their targeting for theestablishment of new therapeutic strategies.

Selected Publications:Baumann U. et al. J Immunol. 2001; 167:1022-1027.Chouchakova N. et al. J Immunol. 2001; 166:5193-5200.Heusohn F. et al. J Immunol. 2002; 168:2857-2864.Radeke HH. et al. J Biol Chem. 2002; 277:27535-27544.Shushakova N. et al. J Clin Invest. 2002; 110:1823-1830.Nieswandt B. et al. Int Immunol. 2003; 15:341-349.Godau J, et al. J Immunol. 2004; 173(5):3437-45Skokowa J, et al. J Immunol. 2005; 174(5):3041-50.Wingender G, et al. Immunology. 2006; 117(1):117-26.Kumar V, et al. J Clin Invest. 2006;116(2):512-20.Konrad S, et al. Br J Haematol. 2006 Aug;134(3):345-7Konrad S, Engling L, Schmidt RE, Gessner JE. J Biol Chem. 2007;282(52):37906-12.Konrad S, Ali SR, Wiege K, et al. J Biol Chem. 2008;283(48):33296-303.

First name:J. Engelbert

Last name:Geßner

Acad. Title:Prof. Dr. rer.nat.Dr. hum.biol.habil.




Department and function:Director, Molecular Biology

Education:1982 B.S. Eberhard-Karls-University, Tübingen,) 1983 M.S. Friedrich-Miescher-Laboratory (FML) of

the Max-Planck-Society, Tübingen1986 Ph.D. Max-Planck-Society, Tübingen1987 - 1989 Postdoc at the Mount Sinai Hospital Res.

Institute, Toronto, Canada

Positions:June 1989- July 1994 Head of an independent research group at

Max-Delbrück-Lab., Cologne, GermanyApril 1994 Habilitation: University of Cologne Aug. 1994 - July 1997 Associate Staff Scientist, The Jackson

Laboratory, Bar Harbor, MEAug. 1997 - June 1999 Staff Scientist , The Jackson Laboratorysince July 1999 Professor for Molecular Biology, MHH

Major research interests:The main research interest of the group lies on the analysis of the molecular mechanisms underlying developmental processes during mammalian embryogenesis. Development of the Notochord The notochord is a transient embryonic structure that serves as a signaling center that is essential for the dorsoventralpatterning of the spinal cord and somites. Various mutations in mice disturb the development or maintenance of the notochord. Identification and functional characterization of the genes affected by these mutations is the subject of several projects. Somitogenesis Somites form as the result of segmentation of the paraxial mesoderm. They give rise to the vertebrae, ribs, the epaxial and hypaxialmuscles and the dorsal dermis. Their formation lays the basis for the metameric arrangement of the vertebrae and of the spinal ganglia. The formation of segments as well as their subdivision into cranial and caudal compartments is the subject of our investigations. We analyse the role of Notch signalling in these processes as well as spontaneous mouse mutants in which somitogenesis is disrupted.

Selected Publications:Schroder N, Sekhar A, Geffers I, Muller J, Dittrich-Breiholz O, Kracht M, Wedemeyer J, Gossler A. Gastroenterology. 2006;130(3):902-7.Schuster-Gossler K, Cordes R, Gossler A. Proc Natl Acad Sci U S A. 2007; 104(2): 537-42.Geffers I, Serth K, Chapman G, Jaekel R, Schuster-Gossler K, Cordes R, SparrowDB, et al. J Cell Biol. 2007;178(3):465-76.Beckers A, Alten L, Viebahn C, Andre P, Gossler A. Proc Natl Acad Sci U S A. 2007; 104(40):15765-70.Feller J, Schneider A, Schuster-Gossler K, Gossler A. Genes Dev. 2008;22(16):2166-71.Sorensen I, Adams RH, Gossler A. Blood. 2009 Jan 14. [Epub ahead of print]Schuster-Gossler K, Harris B, Johnson KR, Serth J, Gossler A.BMC Dev Biol. 2009; 9:6.

First name:Achim

Last name:Gossler





Department and function:Senior scientist (Cardiology & Angiology)

Education:1995 Diploma in Biology (Molecular Biology), University of

Hannover1998 PhD in Biology (Molecular Biology), University of

Würzburg

Positions:1999-2001: Postdoc at the GBF-Braunschweig,

Immunbiology Group2001-recent: Senior scientist at the Dept. of Cardiology & Angiology

of Hannover Medical School

Major research interests:• mechanisms of tissue regeneration• pathophysiology of vascular diseases/atherosclerosis

Selected Publications:Grote K., Flach I., Luchtefeld M., Akin E., et al. Circ Res. 2003; 92: e80-6Grote K., Bavendiek U., Grothusen C., Flach I., et al. J Biol Chem. 2004; 279: 55675-55681.Grote K., Ortmann M., Salguero G., Doerries C., et al. Cardiovasc Res. 2006; 71: 596-605.Luhrmann A., Grote K., Stephan M., Tschernig T., et al. Immunol Lett. 2007; 108): 167-73.Doerries C., Grote K., Hilfiker-Kleiner D., Luchtefeld M., et al. Circ Res. 2007; 100: 894-903.Grote K., Salguero G., Ballmaier M., Dangers M., et al. Blood. 2007; 110: 877-885.

First name:Karsten

Last name:Grote

Acad. Title:Dr.



Further information:www.99.mh-hannover.de/Klinken/kardiologie/html/Forschung009.html

Department and function:Head of Junior Research Group Immunodynamics, HZI

Education:1999 Diploma in Biochemistry, University of

Witten/Herdecke, Witten1999 PhD in Biology (Immunology), University of

Witten/Herdecke, Witten

Positions:2003-2007 Junior Research Group Leader at the HZI,

Braunschweig2007-recent Vice director and professor at Institute of for Molecular

and Clinical Immunology, Magdeburg

Major research interests:Analysis of cell migration in vitro and in vivoT cell activationImmunological defence against pathogens

Selected Publications:Gunzer, M., Kämpgen, E., Bröcker, E.-B., Zänker, K.S., Friedl, P. Adv. Exp. Med. Biol. 1997; 417: 97-103.Gunzer, M., Friedl, P., Niggemann, B., Bröcker, E.-B., Kämpgen, E., Zänker, K.S. J.Leukoc.Biol. 2000; 67: 622-629.Gunzer, M., Schäfer, A., Borgmann, S., Grabbe, S., Zänker, K.S., Bröcker, E.-B., Kämpgen, E., Friedl, P. Immunity 2000; 13: 323-332Gunzer, M., Weishaupt, C., Planelles, L., Grabbe, S. J Immunol Methods 2001; 258: 55-63Gunzer, M., Weishaupt C., Hillmer A., Basoglu Y., Friedl P., Dittmar K.E., KolanusW., Varga G., Grabbe S. Blood 2004; 104:2801-2809.Gunzer M, Riemann H, Basoglu Y, Hillmer A, Weishaupt C, Balkow S, et al. Blood. 2005; 106(7):2424-32.Friedl P, den Boer AT, Gunzer M. Nat Rev Immunol. 2005 Jul;5(7):532-45.Behnsen J, Narang P, Hasenberg M, Gunzer F, Bilitewski U, Klippel N, Rohde M, Brock M, Brakhage AA, Gunzer M. PLoS Pathog. 2007 Feb 2;3(2):e13Reichardt P, Dornbach B, Rong S, Beissert S, Gueler F, Loser K, Gunzer M. Blood. 2007;110(5):1519-29.Geiger H, Koehler A, Gunzer M. Cell Cycle. 2007 Apr 15;6(8):884-7.Niesner R, Andresen V, Neumann J, Spiecker H, Gunzer M. Biophys J. 2007; 93(7):2519-29.Reichardt P, Gunzer F, Gunzer M. Methods Mol Biol. 2007;380:253-69.

First name:Matthias

Last name:Gunzer


Address:Former HZINow:Institute for Immunology,Magdeburg

Phone and e-mail:++49- 391- [email protected]

Further information:http://www.med.uni-magdeburg.de/fme/institute/iim/gunzer_f.html

Department and function:Head Vaccine Research Group, Microbial Pathogenesis and Vaccine Research, Division of Microbiology, HZI Braunschweig

Education:1976-1981 Medicine, National University Rosario, Argentina1982-1986 Specialisation in Bacteriology, Rosario, Argentina 1988 MD, University of Genoa, Italy1989 Qualifying Medical Graduates Examination, School of

Medicine and Surgery, Genoa, Italy1993 PhD in Microbiology, University of Genoa, Italy2000 Habilitation Medical Microbiology, Hanover Medical

School

Positions:Since 1994 Head Vaccine Research, GBF, Braunschweig, Germany1991 - 1993 Laboratory of Microbial Pathogenesis, Univ. Genoa, Italy1989 - 1991 Division of Microbiology, GBF, Braunschweig, Germany1986 - 1989 Institute of Microbiology, Genoa, Italy1982 - 1986 National University of Rosario, Argentina1982 - 1986 Italian Hospital, Rosario, Argentina1982 - 1986 Children Hospital, Rosario, Argentina

Major research interests:Vaccinology, mucosal immunity, development of antigen delivery systems and adjuvants.

Selected Publications:Ebensen T, Schulze K, Riese P, Link C, Morr M, Guzman CA. Vaccine. 2007; 25(8):1464-1469Olive C, Schulze K, Sun HK, Ebensen T, Horvath A, Toth I, Guzman CA. Vaccine. 2007;25(10):1789-97.Ebensen T, Schulze K, Riese P, Morr M, Guzmán CA. Clin Vaccine Immunol. 2007; 14(8):952-8. Ebensen T, Link C, Riese P, Schulze K, Morr M, Guzmán CA. J Immunol. 2007; 179(4):2065-73.Schulze K, Goldmann O, Medina E, Guzmán CA. Int J Med Microbiol. 2008;298(1-2):3-10.Royo JL, Becker PD, Camacho EM, Cebolla A, Link C, Santero E, Guzmán CA. Nat Methods. 2007;4(11):937-42.Cazorla SI, Becker PD, Frank FM, Ebensen T, Sartori MJ, Corral RS, Malchiodi EL, Guzmán CA. Infect Immun. 2008;76(1):324-33Mastini C, Becker PD, Iezzi M, Curcio C, Musiani P, Forni G, Cavallo F, GuzmánCA. Curr Cancer Drug Targets. 2008;8(3):230-42.Cataldi A, Yevsa T, Vilte DA, Schulze K, Castro-Parodi M, Larzábal M, Ibarra C, Mercado EC, Guzmán CA. Vaccine. 2008;26(44):5662-7. Schulze K, Staib C, Schätzl HM, Ebensen T, Erfle V, Guzman CA. Vaccine. 2008 Sep 19. [Epub ahead of print]

First name:Carlos Alberto

Last name:Guzman

Acad. Title:MD, PhD

Address:HZIMascheroder Weg 138124-Braunschweig


Department and function: Director, Nephrology; Chairman, Department of Internal Medicine

Education:1972-1982 Chemistry, Art History, Medicine in

Tübingen, Berlin and Cardiff

Positions:1992-1996 Assistenzarzt FU Berlin1996-1999 Postdoctoral Fellowship Yale University1992-1997 Professor of Medicine, Franz-Volhard-Klinik

at the Max Delbrück Centre, Berlin1999 Professor of Medicine, MHH

Major research interests:I am interested in acute and chronic changes of the vasculature. I havestarted in analysing signal transduction pathways in vascular smooth muscle cells and gradually moved into endothelial cells. Additionally, I am interested in vascular development, circulating endothelialprogenitor cells and stem cells in the kidney.

Selected PublicationsAgrawal R, Marx A, Haller H. J Hypertens. 2006; 24(1):185-92Haller H, Viberti GC, Mimran A, Remuzzi G, Rabelink AJ, Ritz E, et al. J Hypertens. 2006; 24(2):403-8.Menne J, Meier M, Park JK, Boehne M, Kirsch T, Lindschau C, et al. Kidney Int. 2006 Oct;70(8):1456-62. Schwarz A, Rustien G, Merkel S, Radermacher J, Haller H. Nephrol Dial Transplant. 2007 Feb;22(2):584-91Tossidou I, Kardinal C, Peters I, Kriz W, Shaw A, Dikic I, et al. J Biol Chem. 2007 Jan 9; [Epub ahead of print]Meier M, Park JK, Overheu D, Kirsch T, Lindschau C, Gueler F, et al. Diabetes. 2007 Feb;56(2):346-54.Kiyan J, Kusch A, Tkachuk S, Krämer J, Haller H, Dietz R, Smith G, Dumler I. Atherosclerosis. 2007;195(2):254-61.Meier M, Menne J, Park JK, Holtz M, Gueler F, Kirsch T, Schiffer M, Mengel M, Lindschau C, Leitges M, Haller H. J Am Soc Nephrol. 2007;18(4):1190-8.Gueler F, Park JK, Rong S, Kirsch T, Lindschau C, Zheng W, Elger M, Fiebeler A, Fliser D, Luft FC, Haller H. Am J Pathol. 2007;170(4):1192-9.Schwarz A, Vatandaslar S, Merkel S, Haller H. Clin J Am Soc Nephrol. 2007; 2(4):750-6.Meier M, Menne J, Park JK, Haller H. Nephrol Dial Transplant. 2007;22(9):2421-5. Meier M, Menne J, Park JK, Haller H. Nephrol Dial Transplant. 2007;22(9):2421-5. Meier M, Menne J, Haller H. Diabetologia. 2009 Feb 24. [Epub ahead of print]

First name:Hermann

Last name:Haller




Further information:[email protected]

Department and function:Head, Gene Regulation and Differentiation And Division of Molecular Biotechnology, HZI Braunschweig

Education:1969-1974 University of Stuttgart-Hohenheim, Food technology1974-1977 PhD thesis at University of Konstanz, Biology

Positions:1978-1980 Post-Doc at MPI f. Molecular Genetics, Berlin and

DKFZ, Heidelberg1981- Research fellow, group leader, head of dept.,

head of division, HZI, Braunschweig

Major research interests:1.Signal transduction in the cytokine system (signalling molecules and their impact on transcription, cellular and systemic consequences)2.Biotechnology with mammalian cells (protein production, viral vectors, cellular vaccines)

Selected Publications:Spitzer D, Dittmar KE, Rohde M, Hauser H, Wirth D. J Virol. 2003; 77(10):6070-5Koster M, Lykke-Andersen S, Elnakady YA, Gerth K, et al. Exp Cell Res. 2003; 286(2):321-31Unsinger J, Lindenmaier W, May T, Hauser H, Wirth D. Biochem Biophys Res Commun. 2004; 319(3):879-87Niedick I, Froese N, Oumard A, Mueller PP, Nourbakhsh M, Hauser H, Koster M. J Cell Sci. 2004; 117(Pt 16):3447-58Wirth D, Hauser H. Methods Mol Biol. 2004;267:467-76.May T, Hauser H, Wirth D. Nucleic Acids Res. 2004; 32(18):5529-38May T, Wirth D, Hauser H, Mueller PP. Biochem Biophys Res Commun. 2005; 327(3):734-41May T, Mueller PP, Weich H, Froese N, Deutsch U, Wirth D, Kroger A, Hauser H.J Biotechnol. 2005; 120(1):99-110.Froese N, Schwarzer M, Niedick I, Frischmann U, Koster M, Kroger A, Mueller PP, Nourbakhsh M, Pasche B, Reimann J, Staeheli P, Hauser H. Mol Cell Biol. 2006; 26(1):293-302.Frahm T, Hauser H, Koster M. J Cell Sci. 2006 Mar 15;119(Pt 6):1092-104.Schucht R, Coroadinha AS, Zanta-Boussif MA, Verhoeyen E, Carrondo MJ, Hauser H, Wirth D. Mol Ther. 2006 Aug;14(2):285-92.Kröger A, Stirnweiss A, Pulverer JE, Klages K, Grashoff M, Reimann J, Hauser H. Cancer Res. 2007 Apr 1;67(7):2972-81.May T, Hauser H, Wirth D. Methods Mol Med. 2007;140:1-15.May T, Eccleston L, Herrmann S, Hauser H, Goncalves J, Wirth D. PLoS ONE. 2008; 3(6):e2372.

First name:Hansjörg

Last name:Hauser

Acad. Title:Dr. rer. nat

Address:HZIMascheroder Weg 138124 Braunschweig

Phone and e-mail:++49 [email protected]

Further information:www.helmholtz-hzi.de

Department and function:Professor, Molecular Cardiology (Cardiology and Angiology)

Education:1994 PhD in Biology (Genetics and Developmental Biology),

University of ZürichZürich, CH

Positions:1994-1996: Post Doc in the Department of Biology at the EMORY University in Atlanta (Georgia, USA)1997-2001: Post Doc in the Department of Cardiology and

Angiology of Hannover Medical School2001-recent: Group Leader in Molecular Cardiology in the

Department of Cardiology and Angiology2008: Professor of Molecular Cardiology

Major research interests:Analysis of mechanisms of stress-dependent signal transductionresponsible for the transition of compenatory hypertrophy to decompensated hypertrophy in the heart. Focus on the gp130-JAK/STAT signaling pathway and AP-1 transcription factors.Regulation and role of pro-angiogenic gene CCN1 in the pathophysiology of the heart.

Selected Publications:Hilfiker-Kleiner D, Kaminski K, Kaminska A., Fuchs M., Klein G., Podewski E., Kiian I., Wollert K.C., Hilfiker A., Drexler H. Circulation 2004; 109(18):2227-33Hilfiker-Kleiner D, Hilfiker A, Fuchs M, et al. Circ Res. 2004; 95(2):187-95.Schieffer B, Selle T, Hilfiker A, Hilfiker-Kleiner D, et al. Circulation. 2004; 110(22): 3493-500.Hilfiker-Kleiner D, Hilfiker A, Kaminski K, Schaefer A, Park JK, Michel K, Quint A, Yaniv M, Weitzman JB, Drexler H. Circulation. 2005; 112(10):1470-7.Hilfiker-Kleiner D, Hilfiker A, Castellazzi M, Wollert KC, Trautwein C, SchunkertH, Drexler H. Cardiovasc Res. 2006;71(1):108-17.Hilfiker-Kleiner D, Landmesser U, Drexler H. J Am Coll Cardiol. 2006;48(9 Suppl):A56-66Hilfiker-Kleiner D, Kaminski K, Podewski E, Bonda T, Schaefer A, Sliwa K, Forster O, Quint A, Landmesser U, et al. Cell. 2007;128(3):589-600.Hilfiker-Kleiner D, Meyer GP, Schieffer E, Goldmann B, Podewski E, Struman I, Fischer P, Drexler H. J Am Coll Cardiol. 2007;50(24):2354-5.Hilfiker-Kleiner D, Knöll R. Circulation. 2008 Apr 8;117(14):1775-7.Sliwa K, Tibazarwa K, Hilfiker-Kleiner D. Curr Heart Fail Rep. 2008 Dec;5(4):238-44.

First name:Denise

Last name:Hilfiker-Kleiner

Acad. Title:Prof Dr.




Department and function:Professor, Biochemistry (Physiological Chemistry)

Education:1980 Diploma in Biology, University of Hannover1985 Ph. D., Ludwig-Maximilians-University Munich1993 Habilitation in Immunology, Medical School Hannover

Positions:1985-1987: Postdoctoral fellow at the Weizmann Institute of

Science, Rehovot, Israel1987-2001: Group leader, Institute of Pharmacology, Medical

School Hannover2001-2003: GBF-BraunschweigSince 2003: Professor for Biochemistry of Cellular Signal

Transduction, Institute of Biochemistry/Physiological Chemistry, Medical School Hannover

Major research interests:Post-transcriptional control of gene expression in inflammation

- cis-acting RNA elements- regulatory RNA-binding proteins- signalling pathways affecting post-transcriptional mechanisms

Selected Publications:Winzen R., Kracht M., Ritter B., Wilhelm A., Chen C.-Y.A., Shyu A.-B., Müller M., Gaestel M., Resch K., Holtmann. H. EMBO J. 1999; 18:4969-4980.Holtmann H., Winzen R., Holland P., Eickemeier S., Hoffmann E., Wallach D., Malinin N., Cooper J.A., Resch K., Kracht M. Mol. Cell. Biol. 1999; 19:6742-6753.Bollig F., Winzen R., Kracht M., Ghebremedhin B., Ritter B., Wilhelm A., Resch K., Holtmann H. Eur. J. Biochem. 2002; 269:5830-5839.Bollig F, Winzen R, Gaestel M, Kostka S, Resch K, Holtmann H. Biochem BiophysRes Commun. 2003;301(3):665-7Winzen R, Gowrishankar G, Bollig F, Redich N, Resch K, Holtmann H .Mol Cell Biol. 2004; 24(11):4835-47Gowrishankar G, Winzen R, Bollig F, Ghebremedhin B, Redich N, Ritter B, Resch K, Kracht M, Holtmann H. Biol Chem. 2005; 386(12):1287-93. Gowrishankar G, Winzen R, Dittrich-Breiholz O, Redich N, Kracht M, Holtmann H.Biol Chem. 2006;387(3):323-7.Winzen R, Thakur BK, Dittrich-Breiholz O, Shah M, Redich N, Dhamija S, Kracht M, Holtmann H. Mol Cell Biol. 2007;27(23):8388-400.

First name:Helmut

Last name:Holtmann





Department and function: Group Leader, Clinical Immunology

Education:1981-1986 Biology in Hannover

Positions:1987-recent Scientist in the Division of Clinical Immunology, MHH1992 PhD in Biology, MHH2003 Habilitation in Immunology, MHH

Major research interests:Analysis of Natural Killer (NK) cell subpopulations. Our particularinterest is focused on NK cells with weak cytoxic capacity that aresupposed to play an important role in immune regulation.

Selected PublicationsJacobs R, Hintzen G., Kemper A., Beul K., et al. Eur J Immunol 2001; 31: 3121-3126.Jacobs R., Pawlak C. R., Mikeska E., Meyer-Olson D., et al.. Rheumatol 2001; 40: 868-875.Kittner J. M., Jacobs R., Pawlak C. R., Heijnen C. J., Schedlowski M., Schmidt R. E.. Rheumatol 2002; 41: 1031-1039.Straub R. H., Kittner J. M., Heijnen C. J., Schedlowski M., Schmidt R. E., Jacobs R. J Rheumatol 2002; 29: 1659-1664.Jacobs R, Weber K, Wendt K, Heiken H, Schmidt RE J Clin Immunol. 2004; 24(3):281-6Jacobs R, Heiken H, Schmidt RE Mol Immunol. 2005; 42(2):239-49Wendt K, Wilk E, Buyny S, Buer J, Schmidt RE, Jacobs R. J Leukoc Biol. 2006; 80(6):1529-41.Wendt K, Wilk E, Buyny S, Schmidt RE, Jacobs R. Immunology. 2007;122(4):486-95.Wilk E, Kalippke K, Buyny S, Schmidt RE, Jacobs R. Immunobiology. 2008;213(3-4):271-83.

First name:Roland

Last name:Jacobs

Acad. Title:PD Dr.




Department and function:Assistant and research group leader department gastroenterology, hepatology, endocrinology

Education:1996 Master in medicine, University of Hamburg1997 MD, Dept. Pharmacology, Friedrich-Alexander

University, Erlangen

Positions:1996-1999: Research fellow and assistant Dept. Gastroenterology,

MHH, Hannover1998: Research Fellow, German Primate Center Goettingen1999-2003: Postdoctoral fellowship dept. cancer immunology and

AIDS, Dana Farber Cancer Institue, Harvard MedicalSchool, Boston

2003-recent: Assistant and research group leader departmentGastroenterology, Hepatology, Endocrinology

Major research interests:Mechanisms and regulation of immune tolerance in autoimmunity, alloimmunity and chronic infection

Selected Publications:Jaeckel E, Heringlake S, Berger D, Brabant G, Hunsmann G, Manns MP. Diabetes 1999; 48(1):209-14. Jaeckel E, Cornberg M, Santantonio T, Mayer J, et al. New England Journal of Medicine 2001; 345:1452-1457.Jaeckel E, Klein L, Martin-Orozco N, von Boehmer H. J Exp Med 2003; 197: 1635-1644.Wiegand J, Jackel E, Cornberg M, Hinrichsen H, et al. Hepatology 2004; 40:98-107.Jaeckel E, El-Armouche A, Boheler KR, Boknik P, et al. Biochem Biophys Res Comm 2004; 318: 219-226.Jaeckel E, Lipes MA, von Boehmer H. Nat Immunol 2004; 5: 1038-1035.Jaeckel E, von Boehmer H, Manns MP Diabetes 2005; 54: 306-310.Jaeckel E, Kretschmer K, Apostolou I, von Boehmer H. Semin Immunol. 2006; 18(2):89-92Jaeckel E, Mpofu N, Saal N, Manns MP. Horm Metab Res. 2008 Feb;40(2):126-36

First name:Elmar

Last name:Jaeckel

Acad. Title:MD

Address:OE6819TPFZ, K11/01-1450


Further information:www99.mh-hannover.de/kliniken/gastro/gastro.htm

Department and function:Group leader (Institute of Medical Microbiology and Hospital Epidem.)

Education:1996 PhD in Biology (Microbiology/Biochemistry/Cell

Biology), Ruhr-University Bochum, Germany

2003 Habilitation in Medical Microbiology, University of Würzburg, Germany

Positions:1998-1999: Junior Research Group Leader, Dept. Medical

Microbiology, Ruhr-University Bochum, Germany

1999-2000: Post-Doctoral Research, Institute for Cellular Pathology, Université Catholique de Louvain, Bruxelles/Brussel, Belgium

2000-2004: Junior Research Group Leader, Institute for Hygiene and Microbiology, University of Würzburg, Germany

from 2004: Research Group Leader “Cellular Microbiology”Institute for Medical Microbiology and Hospital Epidem. at Hannover Medical School

Major research interests:Characterization of virulence mechanisms of pathogenic bacteriaBacterial sensing, signal transduction and gene regulationBacterial motility and secretion processesInfluence of bacteria on cellular signaling and immune responses in health (commensals) and disease (pathogens) in the gastrointestinal tract

Selected Publications:Schmausser B., Josenhans C., Endrich S., Suerbaum S., et al. Infect. Immun. 2004; 72: 6773-6779.Schreiber S, Bucker R, Groll C, Azevedo-Vethacke M, Garten D, Scheid P, et al. Infect Immun. 2005; 73(3):1584-9Schreiber S, Bucker R, Groll C, Azevedo-Vethacke M, Scheid P, Gatermann S, Josenhans C, Suerbaum S. Arch Microbiol. 2006;184(5):335-40.Andrzejewska J, Lee SK, Olbermann P, Lotzing N, Katzowitsch E, Linz B, et al. J Bacteriol. 2006;188(16):5865-77.Ye F, Niehus E, Drlica K, Josenhans C, Suerbaum S. Int J Med Microbiol. 2007; 297(2):65-81.Sterzenbach T, Lee SK, Brenneke B, von Goetz F, Schauer DB, Fox JG, SuerbaumS, Josenhans C. Infect Immun. 2007;75(6):2717-28.Schweinitzer T, Mizote T, Ishikawa N, Dudnik A, Inatsu S, Schreiber S, SuerbaumS, Aizawa SI, Josenhans C. J Bacteriol. 2008;190(9):3244-55.Sterzenbach T, Bartonickova L, Behrens W, Brenneke B, Schulze J, Kops F, et al. J Bacteriol. 2008 Oct;190(19):6398-408.

First name:Christine

Last name:Josenhans

Acad. Title:P.D. Dr. rer. nat. (Ph.D.)



Further information:www.mh-hannover.de/mikrobiologie.html

Department and function: Head of Department of Toxicology

Education:1976-1980 Pharmacy, Universität Münster1981-1987 Medicine, Freie Universität Berlin

Positions:1989-1995 Postdoc positions in Pharmacology at the Universities

of Giessen, Essen, Homburg/Saar1997 Post Orange Fellowship of INSERM in Nice, France1995-2000 Assistant Professor at the University of Freiburg2000 Professor of Toxicology, MHH

Major research interests:The molecular and cellular mode of action of bacterial proteintoxins and the functional consequences on the signal transductionof the target cells.

Selected PublicationsGerhard, R, John, H, Aktories, K, and Just, I Mol. Pharmacol. 2003; 63:1349-1355Genth H, Gerhard R, Maeda A, Amano M, Kaibuchi K, Aktories K, Just, I. J. Biol. Chem. 2003; 278: 28523-28527Ahnert-Hilger G, Höltje M, Große G, Pickert G, Mucke C, Nixdorf-Bergweiler B, Boquet P, Hofmann F, and Just I. J. Neurochem. 2004; 90:9-18Gerhard, R, Tatge, H., Genth, H., Thum, T., Borlak, J., Fritz, G., and Just, I.J. Biol. Chem. 2005; 280:1499-1505Theodoresu, D, Wittke, S, Ross, MM, Walden, M, Conaway, M, Just, I, Mischak, H, Frierson, H Lancet Oncology 2006; 7:230-240.Genth H, Huelsenbeck J, Hartmann B, Hofmann F, Just I, Gerhard R. FEBS Lett. 2006;580(14):3565-9.Teichert M, Tatge H, Schoentaube J, Just I, Gerhard R. Infect Immun. 2006; 74(10):6006-10.Huelsenbeck J, Dreger S, Gerhard R, Barth H, Just I, Genth H. Infect Immun. 2007; 75(2):801-9.Conrad S, Genth H, Hofmann F, Just I, Skutella T. J Biol Chem. 2007;282(22):16423-33.Huelsenbeck J, Dreger SC, Gerhard R, Fritz G, Just I, Genth H. Biochemistry. 2007; 46(16):4923-31.Nottrott S, Schoentaube J, Genth H, Just I, Gerhard R. Apoptosis. 2007;12(8):1443-53.Meyer GK, Neetz A, Brandes G, Tsikas D, Butterfield JH, Just I, Gerhard R. Infect Immun. 2007;75(8):3868-76.Höltje M, Hofmann F, Lux R, Veh RW, Just I, Ahnert-Hilger G. J Biol Chem. 2008;283(14):9289-99. Gerhard R, Nottrott S, Schoentaube J, Tatge H, Olling A, Just I. J Med Microbiol. 2008;57(Pt 6):765-70.

First name:Ingo

Last name:Just

Acad. title:Prof. Dr.



Further information:http://www.mh-hannover.de/institute/212.html?&no_cache=1/

Department and function:Professor, Molecular Biology of Vertebrates

Education:1983-1989 University of Tübingen, Biochemistry1987-1988 Queen Mary College, London, Biochemistry1989-1990 Diploma thesis, MPI Tübingen1990-1993 PhD thesis, MPI Tübingen

Positions:1993-1994 Postdoc, MPI Tübingen1994-1996 Postdoc, Harvard University1997-2001 Group leader, MPI FreiburgSince 2001 C3 Professor, MHH

Major research interests:Genetic control of vertebrate (mouse) development:- Organogenesis (organs of mesodermal origin like kidneys, skeleton,

muscles, heart)- Function of Wnt and Tbx genes in development

Selected Publications:Kohlhase J, Heinrich M, Liebers M, Frohlich Archangelo L, Reardon W, Kispert A. Cytogenet Genome Res. 2002; 98(4):274-7Moeller C, Swindell EC, Kispert A, Eichele G. Development. 2003; 130(21):5103-11. Bussen M, Petry M, Schuster-Gossler K, Leitges M, Gossler A, Kispert A. Genes Dev. 2004; 18(10):1209-21Haenig B, Kispert A . Dev Genes Evol. 2004; 214(8):407-11.Singh MK, Petry M, Haenig B, Lescher B, Leitges M, Kispert A. Mech Dev. 2005; 122(2):131-44Singh MK, Christoffels VM, Dias JM, Trowe MO, Petry M, Schuster-Gossler K, Burger A, Ericson J, Kispert A. Development. 2005 Jun;132(12):2697-707.Airik R, Bussen M, Singh MK, Petry M, Kispert A. J Clin Invest. 2006;116(3):663-74.Barrionuevo F, Taketo MM, Scherer G, Kispert A. Dev Biol. 2006;295(1):128-40.Christoffels VM, Mommersteeg MT, Trowe MO, Prall OW, de Gier-de Vries C, Soufan AT, Bussen M, Schuster-Gossler K, Harvey RP, Moorman AF, Kispert A. Circ Res. 2006 Jun 23;98(12):1555-63Farin HF, Bussen M, Schmidt MK, Singh MK, Schuster-Gossler K, Kispert A. J BiolChem. 2007 Aug 31;282(35):25748-59.Trowe MO, Maier H, Schweizer M, Kispert A. Development. 2008;135(9):1725-34.Farin HF, Mansouri A, Petry M, Kispert A. J Biol Chem. 2008;283(37):25372-80. Lüdtke TH, Christoffels VM, Petry M, Kispert A.Hepatology. 2008;49(3):969-978.

First name:Andreas

Last name:Kispert





Department and function:Professor and Head of Department; Pediatric Hematology/Oncology

Education:1983-1990 Medical School (University Ulm, Munich)1992 Magister Artium, Philosophy2000 Doctorat Immunology (Institut Pasteur, Paris)

Positions:1990 Residency in Pediatrics, University Munich1991-1994 Residency and Research Associate Hôpital Necker

Enfants Malades, Paris1994-1995 Residency in Pediatrics, University Freiburg1995-1998 Clinical and Research Fellow

Children‘s Hospital, Harvard Medical School Boston1998-2000 Instructor in Pediatrics and Research Associate, Howard

Hughes Medical Instit., Harvard Medical School, Boston2000- Hannover Medical School2008- Head of department Pediatric Hematology/ Oncology

Major research interests:Gene Therapy, Tumor Immunology, Stem Cell Biology

Selected Publications:Snapper SB, Takeshima F, Rosen FS, Antón I, Thomas S, et al. Nat Cell Biol 2001;3:897-904Cloppenborg T, Stanulla M, Zimmermann M, Schrappe M, Welte K, Klein C.Leukemia. 2005; 19(1):44-8.Rathinam C, Geffers R, Yucel R, Buer J, Welte K, Moroy T, Klein C. Immunity. 2005; 22(6):717-28.Maecker B, Mougiakakos D, Zimmermann M, Behrens M, Hollander S, Schrauder A, Schrappe M, Welte K, Klein C. Leukemia. 2006;20(4):645-9.Rathinam C, Sauer M, Ghosh A, Rudolph C, Hegazy A, Schlegelberger B, Welte K, Klein C. Leukemia. 2006;20(5):870-6.Dewey RA, Avedillo Diez I, Ballmaier M, Filipovich A, Greil J, Gungor T, Happel C, Maschan A, et al. Exp Hematol. 2006;34(9):1161-9.Klein C, Grudzien M, Appaswamy G, Germeshausen M, Sandrock I, Schaffer AA, Rathinam C, Boztug K, et al. Nat Genet. 2007;39(1):86-92.Bohn G, Allroth A, Brandes G, Thiel J, Glocker E, Schaffer AA, Rathinam C, Taub N, et al. Nat Med. 2007;13(1):38-45.Rathinam C, Klein C. PLoS ONE. 2007 Mar 21;2(3):e306.Boztug K, Baumann U, Ballmaier M, Webster D, Sandrock I, Jacobs R, et al. Hematologica. 2007; 92(3):e43-5.Maecker B, Jack T, Zimmermann M, Abdul-Khaliq H, Burdelski M, Fuchs A, et al. J Clin Oncol. 2007; 25(31):4902-8.

First name:Christoph

Last name:Klein

Acad. Title:Prof. Dr., PhD


Phone and e-mail:+49-511-532 [email protected]

Further information:www99.mh-hannover.de/Kliniken/paed_haemonko/

Department and function:Assistant Medical Director, Medical Microbiology

Education:1980 - 86 Study of Medicine at the Johannes-Gutenberg University

Mainz1988 - 91 Experimental training in Molecular Biology and Cell

Biology at the Baylor College of Medicine, Department ofCell Biology, Houston, Texas, Medical Center

2000 Consultant with board certification in Med. Microbiol.

Positions:1987 - 88 Research Assistent in the Department of Medical

Microbiology, Johannes-Gutenberg University, Mainz1991 -2000 Research Assistant and, from 2001 on, Assistant Medical

Director at the Department of Medical Microbiology, MHH

Major research interests:Basic research on …1. Chlamydia: Bacteria–host-cell interaction, regulated host-cell genes, mechanisms and signalling pathways2. Complement: Anaphylatoxic peptides C3a, C5a and their G-proteincoupled receptors as part of the innate immunity, receptor regulation on various levels including gene-regulation and interaction with cytokines

Selected Publications:Hess S, Peters J, Bartling G, Rheinheimer C, et al. Cell Microbiol. 2003; 5(11):785-95Otto M, Hawlisch H, Monk PN, Muller M, et al. J Biol Chem. 2004; 279(1):142-51Godau J, Heller T, Hawlisch H, Trappe M, et al. J Immunol. 2004; 173(5):3437-45.Fischer SF, Vier J, Kirschnek S, Klos A, et al. J Exp Med. 2004; 200(7):905-16.Peters J, Hess S, Endlich K, Thalmann J, Holzberg D, Kracht M, Schaefer M, Bartling G, Klos A. Cell Microbiol. 2005; 7(8):1099-108Schaefer M, Konrad S, Thalmann J, Rheinheimer C, Johswich K, Sohns B, Klos A. J Biol Chem. 2005; 280(51):42113-23Johswich K, Martin M, Thalmann J, Rheinheimer C, Monk PN, Klos A. J Biol Chem. 2006;281(51):39088-95.Eickhoff M, Thalmann J, Hess S, Martin M, Laue T, Kruppa J, Brandes G, Klos A.Infect Immun. 2007;75(6):2853-63.Sommer K, Njau F, Wittkop U, Thalmann J, Bartling G, Wagner A, Klos A. FEMS Immunol Med Microbiol. 2008 Dec 9. [Epub ahead of print] Klos A, Thalmann J, Peters J, Gérard HC, Hudson AP. FEMS Microbiol Lett. 2009; 291(1):120-6.

First name:Andreas

Last name:Klos




Further information:www.mh-hannover.de/mikrobiologie.html

Department and function:Former Dept. of Experimental Hematology (head: Prof.Dr.C.Baum),Project Leader

Education:1997 PhD in Biology (Molecular Genetics),

University of Vienna1993 Diploma (Mag.rer.nat.) in Molecular Genetics

University of Vienna

Positions:2009- University Clinics Essen2003-2008: Resarch Associate at the

Institute of Experimental Hematology(head Prof.Dr.C.Baum), Hannover Medical School

1998-2003: Research Associate at the Heinrich-Pette-Institute for Experimental Viroloy and Immunology (HPI), Hamburg

1995-1998: Assistant Professor (“Vertragsassistent”) at the University of Vienna,Institute of Medical Biochemistry.

Major research interests:- In vitro generation of Hematopoietic Stem Cells (HSCs) from

Embryonic Stem (ES-) Cells suitable for transplantation- Manipulation of stem cell self-renewal and differentiation by the

homeodomain transcription factor HOXB.

Selected Publications:Klump,H., Schiedlmeier,B., Vogt, B., et al. Gene Ther, 2001; 8: 811-817.Will, E., Klump, H., Heffner, N., et al. Nucl Acids Res 2002; 30: e59.Schiedlmeier, B., Klump, H., Will, E., et al. Blood 2003; 101: 1759-1768.Pilat, S., Carotta, S., Schiedlmeier, B., et al. PNAS 2005; 102: 12101-12106.Will, E., Speidel, D., Wang, Z. et al. Cell Cycle 2006; 5: 14-22.Schiedlmeier B, Santos AC, Ribeiro A, Moncaut N, Lesinski D, Auer H, KornackerK, Ostertag W, Baum C, Mallo M, Klump H. Proc Natl Acad Sci U S A. 2007; 104(43):16952-7.Chan KM, Bonde S, Klump H, Zavazava N. Blood. 2008;111(6):2953-61.

First name:Hannes

Last name:Klump

Acad. Title:Dr.rer.nat.



Department and function:Group Leader, Biochemistry (Physiological Chemistry)

Education: 1978-1985 Medical School, Charkov, Ukraine1987-1991 PhD thesis

Positions:Research Assistent

Major research interests:MAPK cascades activated by stress or cytokinesSignalling events that are triggered by p38 activity,and analyse how these events contribute to specific gene expression and cellular responses.

Selected Publications:Kotlyarov A., Neininger C., Schubert R., Eckert C., Birchmeier H-D, et al. Nature Cell Biol. 1999; 1: 94-97.Kotlyarov A, Gaestel M. Biochem. Soc. Trans. 2002; 30: 959-963.Kotlyarov A, Yannoni Y, Fritz S, Laaß K, Telliez J-B, et al. Mol. Cell. Biol. 2002; 22: 4827–4835.Shi Y, Kotlyarov A, Laabeta K, Gruber AD, Butt E, et al. Mol Cell Biol. 2003; 23(21):7732-41.Wu Y, Hannigan MO, Kotlyarov A, Gaestel M, Wu D, Huang CK. Biochem BiophysRes Commun. 2004; 316(3):666-7Schumacher S, Laass K, Kant S, Shi Y, et al. EMBO J. 2004; 23(24):4770-9.Hitti E, Iakovleva T, Brook M, Deppenmeier S, Gruber AD, Radzioch D, Clark AR, Blackshear PJ, Kotlyarov A, Gaestel M. Mol Cell Biol. 2006;26(6):2399-407Vertii A, Hakim C, Kotlyarov A, Gaestel M. J Biol Chem. 2006;281(37):26966-75.Kant S, Schumacher S, Singh MK, Kispert A, Kotlyarov A, Gaestel M. J Biol Chem. 2006;281(46):35511-9.Ronkina N, Kotlyarov A, Dittrich-Breiholz O, Kracht M, Hitti E, Milarski K, Askew R, Marusic S, Lin LL, Gaestel M, Telliez JB. Mol Cell Biol. 2007;27(1):170-81.Thomas T, Timmer M, Cesnulevicius K, Hitti E, Kotlyarov A, Gaestel M. J Neurochem. 2008;105(5):2039-52.Thomas T, Hitti E, Kotlyarov A, Potschka H, Gaestel M. Eur J Neurosci. 2008; 28(4):642-54.

First name:Alexey

Last name:Kotlyarov

Acad. Title:MD




Department and function:Director, Institute of Pathology

Education:1976-1982 Study of Medicine, University of Kiel1985 Doctoral thesis, University of Kiel1991 Habilitation , University of Kiel

Positions:1984 - 1993: Institute of Pathology, University of Kiel; senior

registrar since 19911993 - 1998: Professor and Deputy Director Institute of Pathology

University of Würzburgsince 1998: Professor and Head of the Department of Pathology,

Medizinische Hochschule Hannover

Major research interests:Molecular pathology of breast cancer and leukemiasDifferentiation and regeneration of normal tissues

Selected Publications:Mengel M, Gwinner W, Schwarz A, et a..Am J Transplant. 2007;7(2):356-65Hussein K, Bock O, Seegers A, Flasshove M, Henneke F, Buesche G, Kreipe HH. Blood. 2007;109(9):4106-7. Gaedcke J, Traub F, Milde S, et a. Mod Pathol. 2007;20(8):864-70.Hussein K, Bock O, Ballmaier M, Göhring G, Steinemann D, Lehmann U, Kemper J, Buhr T, Kreipe H. Leukemia. 2007;21(12):2566-8. Buesche G, Ganser A, Schlegelberger B, von Neuhoff N, Gadzicki D, Hecker H, Bock O, Frye B, Kreipe H. Leukemia. 2007 Dec;21(12):2420-7.Büsche G, Hussein K, Bock O, Kreipe H. Lancet Oncol. 2007;8(10):863-4.Lehmann U, Hasemeier B, Christgen M, Müller M, Römermann D, Länger F, KreipeH. J Pathol. 2008;214(1):17-24.Hussein K, Bock O, Theophile K, et al. Leukemia. 2007 Nov 1; [Epub ahead of print] Buesche G, Teoman H, Wilczak W, et al. Leukemia. 2008;22(2):313-22.Bock O, Höftmann J, Theophile K, Hussein K, Wiese B, Schlué J, Kreipe H. Am J Pathol. 2008;172(4):951-60.Iannitto E, Ferreri AJ, Minardi V, Tripodo C, Kreipe HH. Crit Rev Oncol Hematol. 2008;68(3):264-71.Lehmann U, Dobbelstein C, Fenner M, Römermann D, Hasemeier B, Metzig K,et al. Ann Hematol. 2009; 88(3):275-7.Wasielewski R, Hasselmann S, Rüschoff J, Fisseler-Eckhoff A, Kreipe H. Virchows Arch. 2008;453(6):537-43.Hussein K, Bock O, Theophile K, Schulz-Bischof K, Porwit A, Schlue J, Jonigk D, Kreipe H. Leukemia. 2009 Feb 5. [Epub ahead of print] Hussein K, Bock O, Theophile K, Schlue J, Ballmaier M, Kröger N, Göhring G, Büsche G, Kreipe H. Blood. 2009 Feb 5;113(6):1391-2.

First name:Hans H.

Last name:Kreipe




Further information:www99.mh-hannover.de/institute/pathologie

Department and function:Head of Immunology, Allergology and Clinical Inhalation Research, ITEM

Education:1981-89 Medicine in Hannover, Göttingen and Hartford (USA)1998-2000 Degree in Internal Medicine, Respiratory Medicine,

Allergology and Intensive Care Medicine, Hannover Medical School (MHH)

1999 Habilitation in Internal Medicine (MHH)

Positions:1989-93 and1995-2000: Assistenzarzt Medical School Hannover (MHH)1993-95: Postdoctoral Fellowship University Bochum and

University Southampton (German Research CouncilScholarship)

since 2000: Professor of Immunology, Allergology and Clinical Inhalation Research, MHHand Head of Department Immunology, Allergology and Clinical Inhalation Research, Fraunhofer ITEM

Major research interests:Pathophysiology and therapeutic interventions of airway diseases, in particular asthma. Preclinical and clinical research.

Selected Publications:Erpenbeck VJ, Hagenberg A, Krentel H, Discher M, Braun A, Hohlfeld JM, Krug N. Int Arch Allergy Immunol. 2006;139(4):306-316Erpenbeck VJ, Ziegert M, Cavalet-Blanco D, Martin C, Baelder R, Glaab T, Braun A, Steinhilber W, et al. Clin Exp Allergy. 2006;36(7):930-40.Larbig M, Burtin B, Martin L, Stamm H, Luettig B, Hohlfeld JM, Krug N. Br J ClinPharmacol. 2006;62(2):158-64.Nassenstein C, Dawbarn D, Pollock K, Allen SJ, Erpenbeck VJ, Spies E, Krug N, Braun A. J Allergy Clin Immunol. 2006;118(3):597-605.Veres TZ, Rochlitzer S, Shevchenko M, Fuchs B, Prenzler F, Nassenstein C, Fischer A, Welker L, Holz O, Müller M, Krug N, Braun A. Am J Respir Cell Mol Biol. 2007; 37(5):553-61Nassenstein C, Kammertoens T, Veres TZ, Uckert W, Spies E, Fuchs B, Krug N, Braun A. J Allergy Clin Immunol. 2007;120(5):1089-96.Schaumann F, Müller M, Braun A, Luettig B, Peden DB, Hohlfeld JM, Krug N. Am J Respir Crit Care Med. 2008 Jun 15;177(12):1307-13. Badorrek P, Dick M, Schauerte A, Hecker H, Murdoch R, Luettig B, Hohlfeld JM, Krug N. Int J Clin Pharmacol Ther. 2009 Feb;47(2):71-7.

First name:Norbert

Last name:Krug


Address:Fraunhofer Institute forToxicology and Experimental MedicineNikolai-Fuchs-Str. 130625 Hannover


Further information:www.item.fraunhofer.de

Department and f unction:Group Leader and Head of the Laboratory of Molecular Diagnostics; Pathology

Education:1986-1992 University of Hannover, Biochemistry1992-1996 PhD, Molecular Biology

Positions:1996-1998 Head Laboratory of Molecular Diagnostics

Institute of Pathology, Bielefeldsince 1999 Research Group Leader and Head of the

Laboratory of Molecular Diagnostics,Institute of Pathology, Hannover Medical School

Major research interests:Epigenetics of malignant neoplasiaTumor evolutionMolecular diagnosis of neoplasiaMain focus on breast cancer and hematological neoplasia in humans

Selected Publications:Tessema M, Langer F, Bock O, et al. Int J Oncol. 2005; 26(2):499-507.Langer F, Dingemann J, Kreipe H, Lehmann U. Leuk Res. 2005; 29(3):325-9.Lehmann U, Berg-Ribbe I, Wingen LU, et al. Clin Cancer Res. 2005; 11(10):3654-60.Brakensiek K, Langer F, Kreipe H, Lehmann U. Leuk Res. 2005; 29:1357-60.Brakensiek K, Langer F, Schlegelberger B, Kreipe H, Lehmann U. Br J Haematol. 2005; 130(2):209-17.Lehmann U, Kreipe H. Methods Mol Med. 2006;120:65-75.Brocker V, Langer F, Fellous TG, et al. Am J Respir Crit Care Med. 2006;173(11):1276-82.Brakensiek K, Wingen LU, Langer F, Kreipe H, Lehmann U. Clin Chem. 2007; 53(1):17-23.Lehmann U, Wingen LU, Brakensiek K, et al. Hum Mol Genet. 2007; 16(11):1335-42.Christgen M, Ballmaier M, Bruchhardt H, von Wasielewski R, Kreipe H, Lehmann U. Mol Cell Biochem. 2007;306(1-2):201-12.Christgen M, Lehmann U. Cancer Biol Ther. 2007;6(9):1355-7.Lehmann U, Hasemeier B, Christgen M, et al. J Pathol. 2008;214(1):17-24.Römermann D, Hasemeier B, Metzig K, et al. Leukemia. 2008;22(10):1954-6. Lehmann U, Dobbelstein C, Fenner M, et al. Ann Hematol. 2009; 88(3):275-7. Christgen M, Bruchhardt H, Ballmaier M, Krech T, Länger F, Kreipe H, Lehmann U. Int J Cancer. 2008 Nov 15;123(10):2239-46.Hasemeier B, Christgen M, Kreipe H, Lehmann U. BMC Biotechnol. 2008;8:90Christgen M, Bruchhardt H, Hadamitzky C, et al. J Pathol. 2008 Nov 10. [Epubahead of print]

First name:Ulrich

Last name:Lehmann




Further information:www99.mh-hannover.de/ institute/pathologie/

Department and function:Project leaderDept. Experimental Hematology

Education:1993 Master of Medicine (equivalent to MD)

Tongji Medical School, Wuhan, PR. China1998 MD, University of Hamburg, Hamburg2006 Habilitation and venia legendi in

Experimental Hematology, Hannover Medical School

Positions:1993-1995 Clinical and Research fellow, Tongji Medical School1995-1996 Clinical fellow, Clinic of Dr. Kleeberg (HOPA, Hamburg)1996-1998 Research fellow, Center for Bone Marrow

Transplantation, University Hospital Eppendorf,Hamburg

1999-2002 Faculty member and Deputy Director Department of HematologySun Yat-Sen Memorial HospitalSun Yat-Sen University, Guangzhou, PR. China

2000-2002 Postdoctoral fellowDepartment of Cell & Virus GeneticsHeinrich-Pette-Institute, University of Hamburg

2001-04.2006 Staff scientist, project leaderDept. Hematology, Hemostaseology and Oncology Hannover Medical School

04.2006- Project leader, Dept. Experimental Hematology

Major research interests:1) Leukemogenesis of receptor tyrosine kinases;2) Stem cell biology; 3) Gene therapy

Selected Publications:Li Z et al., Science 2002;296:497Li Z et al., Leukemia 2002;16:1655-63Baum C et al., Blood 2003;101:2099-2113Beutel G et al., Br J Haematol 2005;131:67-70Kustikova OS et al., Science 2005;308:1171-1174Kustikova OS et al., Blood 2007;109:1897-907Meyer J et al., Leukemia 2007;21:2171-2180Newrzela S et al., Blood 2008;112:2278-2286Daria D et al., Blood 2008;111:1894-902Li Z et al., Blood 2009, in press

First name:Zhixiong

Last name:Li

Acad. Title:PD Dr.med.



Department and functionGroup Leader, Cell Biology

Education:1982-1987 Biology, Technical University of Munich1988-1992 PhD Thesis, MPI for Biochemistry, Martinsried

Positions:1992-1997 Postdoc at Washington University, St. Louis, MO, USA1997-2000 Assistant in the Department of Immunobiology,

University of Bonnsince 2000 Assistant in the Department of Cell Biology

Major research interests:Antigen processing and presentation; intracellular sorting of MHC II molecules, antigens and cofactors for antigen processing; lipid rafts and their function in MHC II biology; roles of intestinal epithelial cells in mucosal immunity

Selected Publications:Lindner R., Unanue E. EMBO J. 1996; 15: 6910-6920.Lindner R. Electrophoresis 2001; 22: 386-393.Lindner R. Traffic 2002; 3: 133-146.Karacsonyi C, Knorr R, Fulbier A, Lindner R J Biol Chem. 2004; 279(33):34818-2Karacsonyi C, Bedke T, Hinrichsen N, Schwinzer R, Lindner R. J Leukoc Biol. 2005; 78(5):1097-105.

First name:

Robert

Last name:Lindner



Phone and e-mail:++49- 511- 532-2918

[email protected]

Further information:www99.mh-hannover.de/Institute/Zellbiologie/

Department and function:Group Leader, Gastroenterology, Hepatology and Endocrinologyand Molecular Biology

Education:6/96 MD1/98-12/00 Post Doc Fred Hutchinson Cancer Center, Seattle WA;

USA

Positions:since 1/96 Dept. of Gastroenterology, MHHsince 2/01 Dept.of Gastroenterology and Institute for Molecular

Biology

Major research interests:My scientific interest concentrates on the understanding of themammalian cell cycle, specifically on the control of cyclin dependentkinases. Our research tries to elucidate the molecular regulation of cyclin kinase inhibitors by proteolytic mechanisnms. We are usingbiochemistry and mouse models as our main tools.

Selected Publication:Malek NP, Sundberg H, McGrew S, Nakayama K, Kyriakides TR, Roberts J. Nature2001; 413: 323-27.Zender L, Hutker S, Liedtke C, Tillmann HL, Zender S, et al. Proc Natl Acad SciUSA 2003; 100(13):7797-802.Kossatz U, Dietrich N, Zender L, Buer J, Manns MP, Malek NP. Genes Dev. 2004; 18(21):2602-7Timmerbeul I, Garrett-Engele CM, Kossatz U, Chen X, Firpo E, Grunwald V, Kamino K, Wilkens L, Lehmann U, Buer J, Geffers R, Kubicka S, Manns MP, Porter PL, Roberts JM, Malek NP. Proc Natl Acad Sci U S A. 2006;103(38):14009-14.Kossatz U, Vervoorts J, Nickeleit I, Sundberg HA, Arthur JS, Manns MP, Malek NP. EMBO J. 2006;25(21):5159-70.Nickeleit I, Zender S, Kossatz U, Malek NP. Cell Div. 2007;2:13.Kossatz U, Malek NP. Cell Res. 2007;17(10):832-3. Nickeleit I, Zender S, Sasse F, Geffers R, Brandes G, Sörensen I, Steinmetz H, Kubicka S, Carlomagno T, Menche D, Gütgemann I, Buer J, Gossler A, Manns MP, Kalesse M, Frank R, Malek NP. Cancer Cell. 2008 Jul 8;14(1):23-35.

First name:Nisar Peter

Last name:Malek




Further information:http://www99.mh-hannover.de/ kliniken/gastro/gastro.htm

Department and function:Director, Biophysical Chemistry

Education:1986 PhD in Biochemistry, Heidelberg University1999 Venia Legendi for Biochemistry and Biophysics, Heidelberg University

Positions:1986 Research Associate, University of Michigan, USA1987-1990 Postdoctoral Fellow, Stanford University, USA1990-1996: Group Leader, National Institute for Medical

Research, London, UK1996-2002: Senior Group Leader, Max-Planck-Institute for

Medical Research, Heidelberg2002-: Professor of Biophysical Chemistry, MHH

Major research interests:Molecular motorsRegulation of dynamic changes in the cytoskeleton associated with cellmovements and cytokinesisG-protein mediated processes

Selected Publications:Knetsch, M.L.W., Schäfers, N., Horstmann, H., Manstein, D. J. EMBO J 2001, 20: 1620-1629.Klockow, B., Tichelaar, W., Madden, D., Niemann, H.H., Akiba, T., Hirose, K., Manstein, D.J. EMBO J 2002, 21: 240-250.Krylyshkina, O., Manstein, D.J. et al. J. Cell Biol. 2003, 161: 853-859.Reubold, T.F., Eschenburg, S., Becker, A., Kull, F.J., Manstein, D.J. Nature Struct. Biol2003, 10: 826-830.Tsiavaliaris G, Fujita-Becker S, Manstein DJ. Nature. 2004; 427(6974):558-61.Fujita-Becker S, Durrwang U, Erent M, Clark RJ, Geeves MA, Manstein DJ. J BiolChem. 2005; 280(7):6064-71Reubold TF, Eschenburg S, Becker A, Leonard M, Schmid SL, Vallee RB, Kull FJ, Manstein DJ. Proc Natl Acad Sci U S A. 2005; 102(37):13093-8.Durrwang U, Fujita-Becker S, Erent M, Kull FJ, Tsiavaliaris G, Geeves MA, Manstein DJ. J Cell Sci. 2006; 119(Pt 3):550-8.Fujita-Becker S, Tsiavaliaris G, Ohkura R, Shimada T, Manstein DJ, Sutoh K. J BiolChem. 2006;281(47):36102-9.Fedorov R, Witte G, Urbanke C, Manstein DJ, Curth U. Nucleic Acids Res. 2006;34(22):6708-17.Tsiavaliaris G, Fujita-Becker S, Dürrwang U, Diensthuber RP, Geeves MA, Manstein DJ. J Biol Chem. 2008;283(8):4520-7.Fedorov R, Böhl M, Tsiavaliaris G, Hartmann FK, Taft MH, Baruch P, Brenner B, Martin R, Knölker HJ, Gutzeit HO, Manstein DJ. Nat Struct Mol Biol. 2009;16(1):80-8.

First name:Dietmar

Last name:Manstein





Department and function:Professor and Head Leibniz Research Labs for Biotechnology andArtificial Organs (LEBAO), Department of Cardiac-, Thoracic-, Transplantation and

Vascular Surgery, Co-coordinator REBIRTH - Center for Regenerative Medicine

Education:1997 PhD in Biology, University of Hannover2001 Habilitation in Molecular Biology, Hannover Medical School

Positions:1997 Postdoctoral position at the Leibniz Research Laboratories for Biotechnology

and Artificial Organs (LEBAO), Hannover Medical School, Subject of research: Xenotransplantation

2001 Head of the section “Molecular Biotechnology and Stem Cell Research” and laboratory manager of the LEBAO.

2003 Assistant Professor for “Experimental Transplantation” at Hannover Medical School.

2004 Head of the DFG Clinical Research Unit “Lung Transplantation”.2005 Associate Professor for ““Experimental Lung Transplantation” at Hannover

Medical School2006 Visiting Professor and Member of the Scientific Advisory Board at People’s

Friendship University, Sochi, Russia2006 Deputy Coordinator of the Excellence Cluster “REBIRTH-From Regenerative

Biology to Reconstructive Therapy”2008 Full professor for `Cardiorespiratory Tissue Engineering` at Hannover Medical

School and head of the Leibniz Research Laboratories for Biotechnology and Artificial Organs

Major research interests:Stem cells, tissue engineering, cardio respiratory regeneration

Selected Publications:1. Mauritz, C., Schwanke, K., Reppel, M., et al. 2008. Generation of functional murine cardiac

myocytes from induced pluripotent stem cells. Circulation 118, no. 5:507.2. Winkler, M.E., Mauritz, C., Groos, S., et al. 2008. Serum-Free Differentiation of Murine

Embryonic Stem Cells into Alveolar Type II Epithelial Cells. Cloning Stem Cells 10, no. 1:49.

3. Martin, U. 2008. Methods for studying stem cells: Adult stem cells for lung repair. Methods45, no. 2:121.

4. Gruh, I., Wunderlich, S., Winkler, M., et al. 2008. Human CMV immediate-early enhancer: a useful tool to enhance cell-type-specific expression from lentiviral vectors. J Gene Med10, no. 1:21.

5. Wunderlich, S., Gruh, I., Winkler, M.E., et al. 2007. Type II Pneumocyte-Restricted Green Fluorescent Protein Expression After Lentiviral Transduction of Lung Epithelial Cells. Hum Gene Ther.

6. Schwanke, K., Wunderlich, S., Reppel, M., et al. 2006. Generation and characterization of functional cardiomyocytes from rhesus monkey embryonic stem cells. Stem Cells 24, no. 6:1423.

7. Gruh, I., Beilner, J., Blomer, U., et al. 2006. No evidence of transdifferentiation of human endothelial progenitor cells into cardiomyocytes after coculture with neonatal rat cardiomyocytes. Circulation 113, no. 10:1326.

8. Donath, S., Li, P., Willenbockel, C., et al. 2006. Apoptosis repressor with caspaserecruitment domain is required for cardioprotection in response to biomechanical and ischemic stress. Circulation 113, no. 9:1203.

9. Blomer, U., Gruh, I., Witschel, H., et al. 2005. Shuttle of lentiviral vectors via transplanted cells in vivo. Gene Ther 12, no. 1:67.

10. Amit, M., Winkler, M.E., Menke, S., et al. 2005. No evidence for infection of human embryonic stem cells by feeder cell-derived murine leukemia viruses. Stem Cells 23, no. 6:761.

First name:Ulrich

Last name:Martin




Further information:www.lebao.dewww.rebirth-hannover.de

Department and function:Department of Pulmonary MedicineHead, Laboratory for Experimental Lung Research

Education:1996 PhD in Biology, Justus-Liebig-University Giessen

2005 Habilitation in Molecular Medicine, Justus-Liebig-University Giessen

Positions:1997-1999: Post-Doc and Project Co-leader, SFB 547

“Cardiopulmonary Vascular System”, JLU Giessen1999-2004: Assistant Professor of Experimental Lung Research;

Justus-Liebig-University Giessen2005-recent: Head, Laboratory for Experimental Lung Research,

Hannover School of Medicine

Major research interests:Pathobiology of mononuclear phagocytes in acute and chronic lunginfections

Selected Publications:Holschermann H, Durfeld F, Maus U, et al. Blood 1996, 88: 3837.Maus U, v. Grote K, Kuziel WA, et al. Am J Respir Crit Care Med 2002; 166:268.Maus U, Huwe J, Ermert L, et al. Am J Respir Crit Care Med 2002; 165: 95.Maus UA, Waelsch K, Kuziel WA, et al. J Immunol 2003; 170: 3273.Maus U, Srivastava M, Paton JC, et al. J Immunol 2004; 173: 1307.Srivastava M, Jung S, Wilhelm J, et al. J Immunol 2005; 175: 1884 Maus U, Janzen S, Wall G, et al. Am J Respir Cell Mol Biol 2006; 35: 227.Srivastava M, Meinders A, Steinwede K, et al. Cell. Microbiol. 2007; 9:738.Maus UA, Backi M, Winter C, Srivastava M, Schwarz MK, Rückle T, et al. Am J Respir Crit Care Med. 2007;175(9):958-66.Winter C, Taut K, Srivastava M, Länger F, Mack M, Briles DE, Paton JC, Maus R, Welte T, Gunn MD, Maus UA. J Immunol. 2007;178(9):5828-38.Winter C, Taut K, Länger F, Mack M, Briles DE, Paton JC, Maus R, Srivastava M, Welte T, Maus UA. J Immunol. 2007;179(5):3099-108.von Wulffen W, Steinmueller M, Herold S, Marsh LM, Bulau P, Seeger W, Welte T, Lohmeyer J, Maus UA. Am J Respir Crit Care Med. 2007;176(9):892-901Taut K, Winter C, Briles DE, Paton JC, Christman JW, Maus R, Baumann R, WelteT, Maus UA. Am J Respir Cell Mol Biol. 2008;38(1):105-13.Srivastava M, Steinwede K, Kiviranta R, Morko J, Hoymann HG, Länger F, BuhlingF, Welte T, Maus UA.Respir Res. 2008;9:54.Schreiber O, Steinwede K, Ding N, Srivastava M, Maus R, Länger F, Prokein J, Ehlers S, Welte T, Gunn MD, Maus UA. J Infect Dis. 2008;198(7):1044-54.

First name:Ulrich

Last name:Maus

Acad. Title:Priv.-Doz. Dr.

Address:OE 6875Hannover School of Medicine


Further information:www.mh-hannover.de/3053.html

Department and function:Head of Infection Immunology Research Group

Education:1990 PhD in Clinical Biochemistry, University Medical

School, Seville, Spain

Positions:1991-1993: Postdoctoral Research fellow in the Immunology

Department at the Royal Free Hospital School of Medicine, London, UK.

1993-1996: Postdoctoral fellow at the Trudeau Institute, Saranac Lake, NY, USA.

1997-2004: Scientist in the Division of Microbiology, GBF-German Research Center for Biotechnology, Braunschweig, Germany.

2004-recent: Appointed Head of the Infection Immunology Research Group (INI), Department of Microbial Pathogenesis, HZI- Helmholtz Zentrum für Infektion Forschung, Braunschweig, Germany.

Major research interests:To unravel the dynamic processes involving the host response to gram-positive pathogens, in particular to Streptococcus pyogenes and Staphylococcus aureus, and the ability of these pathogens to evade, breach or suppress the host immune defences.

Selected Publications:Medina E. and North R.J. J. Exp. Med. 1996; 183:1045-1051.Medina E., Molinari G., Rohde M., Chhatwal G.S. and Guzmán C.A. J. Immunol. 1999; 163: 3396-3402.Goldmann O., Chhatwal G.S., and Medina E. J. Infect. Dis. 2003; 187: 854-861.Goldmann O., Lengeling A., Böse J, Bloecker H., Geffers R. et al. J. Immunol. 2005; 175: 3862-3872.von Köckritz-Blickwede M., Goldmann O., Thulin P., Heinemann K., Norrby-Teglund A., et al. Blood. 2008;111(6):3070-80. Loof TG, Rohde M, Chhatwal GS, Jung S, Medina E. J Infect Dis. 2007; 196(12):1794-803.Loof TG, Goldmann O, Medina E. Infect Immun. 2008;76(6):2785-92. von Köckritz-Blickwede M, Rohde M, Oehmcke S, Miller LS, Cheung AL, Herwald H, Foster S, Medina E. Am J Pathol. 2008;173(6):1657-68. Goldmann O, Sastalla I, Wos-Oxley M, Rohde M, Medina E. Cell Microbiol. 2009 Jan;11(1):138-55.

First name:Eva

Last name:Medina

Acad. Title:Dr.

Address:Inhoffenstraße 7Helmholtz Center for Infection Research



Department and function:Professor, Senior Research Group leader

Education:1961 Dipl. chem.., University of Cologne, Germany1964 Ph.D. (Dr.rer.nat.), University of Cologne, Germany1971 Dr.rer.nat. habil., Venia legendi, University of Freiburg

i.Br. Germany Faculty of Biology

Positions:1965-67 Research Associate, Salk Institute for Biological

Studies, La Jolla, CA, USA (Fulbright Travel Scholar)1968-69 Postdoctoral Fellow, Max Planck Institute for Molecular

Genetrics, Beriln, Germany1970 Senior Research Assistant, Max Planck Institute for

Molecular Genetrics, Berlin, Germany1970 Visiting Scientist, Weizmann Institute, Rehovot, Israel1970-71 Visiting Scientist, Department of Genetics, Stanford

University Medical School, Stanford, CA1970-1980 Permanent Member, Basel Institute for Immunology,

Basel, Switzerland1980-2001 Director, Basel Institute for Immunology, Basel,

Switzerland2003- Senior Research Group Leader, Max Planck Institute for

Infection Biology, Berlin, Germany

Major research interests:The senior group will continue to work on some projects which were developed at the Basel Institute for Immunology and which have focused on the development of cells of the innate and adaptive from stem cells and early progenitors and which have studied the development of B-lymphocytes in greater details.

Selected Publications:Shimizu T, Mundt C, Licence S, Melchers F, Martensson IL. J Immunol. 2002; 168: 6286-93.Rolink AG, Schaniel C, Melchers F. Immunol Rev. 2002; 187, 87-95.Hoffmann R, Bruno L, Seidl T, Rolink AG, Melchers F. J Immunol. 2003; 170:1339-53.Ohnishi K, Melchers F. Nat Immunol. 2003; 4:849-56.Melchers F. Nat Rev Immunol. 2005; 5:578-84.Melchers F, Rolink AR. Curr Top Microbiol Immunol. 2006;305:1-23.Melchers F. Immunity. 2006;25(6):864-7.Hoffmann R, Lottaz C, Kühne T, Rolink A, Melchers F. Mol Biol Evol. 2007; 24(12):2610-8. Melchers F. Eur J Immunol. 2007;37 Suppl 1:S125-33.

First name:Fritz

Last name:Melchers


Address:Max Planck Institute for Infection BiologyCampus Charité MitteSchumannstr. 21/2210117 Berlin, Germany


Further information:http://www.mpiib-berlin.mpg.de/

Department and function:Associate Professor, Virology

Education:1990 PhD in Biology (Genetics), Eberhard Karls-University

Tübingen2002 Habilitation in Experimental Virology,

Ludwig Maximilians-University München

Positions:1991-1994: Postdoc at the Department of Virology, University

of Ulm and Department of Haematology and Oncology, University of Freiburg

1995-2001: Research Group Leader at the Department of Virology, University of Heidelberg and at the Max von Pettenkofer-InstituteLudwig-Maximilians-University München

2001-2004: Leader of the Virus-Cell-Interaction Unit at the Medical Faculty, University of Halle-Wittenberg

since 2005: Professor of Molecular Virology, Hannover Medical School

Major research interests:Analysis of viral proteins involved in the interaction of herpesviruseswith their host cellsImmunomodulation by herpesvirusesDevelopment of viral vectors for gene transfer, vaccination and tumortherapy

Selected Publications:Borst E., Hahn G., Koszinowski U.H., Messerle M. J. Virol. 1999; 73:8320-8329. Borst E., Mathys S., Wagner M., Muranyi W., Messerle, M. J. Virol. 2001; 75:1450-1458.Mathys S., Schroeder T., Ellwart J., Koszinowski U.H., Messerle M., Just U. J. Inf. Dis. 2003; 187:988-999.Borst E., Messerle M. Hum. Gene Ther. 2003; 14:959-970. Loewendorf A., Krueger C., Borst E., Wagner M., Just U., Messerle M. J. Virol. 2004; 78:13062-13071.Borst E., Messerle, M. J. Virol. 2005; 79(6):3615-26.Gustems M, Borst E, Benedict CA, Perez C, Messerle M, Ghazal P, Angulo A. J Virol. 2006;80(19):9899-904.Borst EM, Wagner K, Binz A, Sodeik B, Messerle M. J Virol. 2008;82(5):2065-78.Glass M, Soling A, Messerle M. J Neurovirol. 2008 Oct 31:1-14. Busche A, Marquardt A, Bleich A, Ghazal P, Angulo A, Messerle M. J Virol. 2009 Feb 11. [Epub ahead of print]

First name:Martin

Last name:Messerle




Further information:www99.mh-hannover.de/institute/virologie/home.html

Department and function:Group Leader Molecular Genetic Diagnostics

Education:1988-1994 Study of marine biology, University of Kiel

Main focus: marine pathology1994 Thesis at Robert Koch Institut Berlin (AIDS Zentrum)1999 PhD in cell biology, University of Kiel

Positions:1994-2000: Group Leader, Stem Cell Transplantation Unit of the II.

Medical Clinic, University of Kiel2001 Head of Molecular Genetic Diagnostics, Institute of Cell

and Molecular Pathology, Hannover Medical School

Major research interests:- Modification of steroid resistance in childhood leukemia(ALL) by differentially expressed peptides and proteins-Mesenchymal stem cells and wnt-pathway regulation

Selected Publications:von Neuhoff N, Kaiser T, Wittke S, Krebs R, et al. Rapid Commun. Mass Spectrom2004; 18: 149-156Janke, V., von Neuhoff, N., Schlegelberger, B., Leyhausen, G., Geurtsen, W. Biomaterials. 2004; 25(19):4573-80.Ritgen M, Stilgenbauer S, von Neuhoff N, Humpe A, et al. Blood. 2004; 104:2600-2.Rudolph C, Steinemann D, von Neuhoff N, Gadzicki D, et al. Cancer Genet Cytogenet. 2004; 153(2):144-50.Cario G, Stanulla M, Fine BM, Teuffel O, Neuhoff NV, et al. Blood. 2005; 105(2):821-6.Dammann CE, Meyer M, Dammann O, von Neuhoff N. Biol Neonate. 2006; 89(2):126-32Lauten M, Schrauder A, Kardinal C, Harbott J, Welte K, Schlegelberger B, SchrappeM, von Neuhoff N. Leukemia. 2006;20(5):820-6.Balakrishnan A, von Neuhoff N, Rudolph C, Kamphues K, Schraders M, Groenen P, van Krieken JH, Callet-Bauchu E, Schlegelberger B, Steinemann D. Genes Chromosomes Cancer. 2006;45(10):883-92.Ripperger T, von Neuhoff N, Kamphues K, Emura M, Lehmann U, Tauscher M, Schraders M, Groenen P, Skawran B, Rudolph C, Callet-Bauchu E, van Krieken JH, Schlegelberger B, Steinemann D. Haematologica. 2007;92(4):460-8.Bertram C, von Neuhoff N, Skawran B, Steinemann D, Schlegelberger B, Hass R.BMC Cell Biol. 2008;9:12.

First name:Nils

Last name:von Neuhoff




Further information:www.mh-hannover.de/Zellpathologie.html

Department and function:Head, Biotechnology; FAL

Education:1973-1978 Veterinary Sciences, Veterinary University Hannover1978-1980 PhD thesis1985/86 Texas A&M University, College of Veterinary

Medicine1989: Habilitation Veterinary University Hannover1994: Apl. Professor for Reproductive Biology Veterinary

University Hannover

Positions:1980-1987: Scientist at the Institute for Animal Science1987-now: Head of Dept. Biotechnology at the Institute2008: Head of Institute of Farm Animal Genetics

Major research interests:Molecular regulation of preimplantation developmentTransgenesis in domestic species, Use of agricultural animals forbiomedical applications, Aspects of somatic cloningGenetic diversity

Selected Publications:Gebert C, Wrenzycki C, Herrmann D, Groger D, Reinhardt R, Hajkova P, Lucas-Hahn A, Carnwath J, Lehrach H, Niemann H. Genomics. 2006;88(2):222-9Kues WA, Schwinzer R, Wirth D, Verhoeyen E, Lemme E, Herrmann D, Barg-Kues B, Hauser H, Wonigeit K, Niemann H. FASEB J. 2006;20(8):1200-2.Ehling C, Rath D, Struckmann C, Frenzel A, Schindler L, Niemann H. Theriogenology. 2006;66(9):2160-4.Kues WA, Ollhoff RD, Carnwath JW, de Souza FP, Madeira HM, Niemann H. J Anim Breed Genet. 2006;123(5):326-30.Wrenzycki C, Herrmann D, Gebert C, Carnwath JW, Niemann H. Methods Mol Biol. 2006;348:285-304.Horn PA, Tani K, Martin U, Niemann H. Cloning Stem Cells. 2006;8(3):124-9Schwarzer M, Carnwath JW, Lucas-Hahn A, Lemme E, Kues WA, Wachsmann B, Haverich A, Martin U, Niemann H. Cloning Stem Cells. 2006;8(3):150-8.Iqbal K, Kues WA, Niemann H. Biochem Biophys Res Commun. 2007;358(3):727-32Racedo SE, Wrenzycki C, Herrmann D, Salamone D, Niemann H. Mol ReprodDev. 2008;75(1):17-25.Hornen N, Kues WA, Carnwath JW, Lucas-Hahn A, Petersen B, Hassel P, Niemann H. Cloning Stem Cells. 2007;9(3):364-73.Nowak-Imialek M, Wrenzycki C, Herrmann D, Lucas-Hahn A, Lagutina I, LemmeE, Lazzari G, Galli C, Niemann H. Mol Reprod Dev. 2008;75(5):731-43.Niemann H, Tian XC, King WA, Lee RS. Reproduction. 2008;135(2):151-163.

First name:Heiner

Last name:Niemann

Acad. Title:Prof. Dr. med.vet. Dr.habil.

Address:Dept. BiotechnologyInstitute of Farm AnimalGenetics, MarienseeFAL, Hoeltystr. 1031535 Neustadt

Phone and e-mail:++49-(0)[email protected]

Further information:www.fli.bund.de

Department:Gastroenterology, Hepatology and Endocrinology

Education:1994-2001 Medical studies at Medical School Hannover2001 Doctoral thesis, Department of Anesthesiology,

Medical School Hannover

Positions:2001-2002: Internship at the Department of Gastroenterology,

Hepatology and Endocrinology, Medical School Hannover, Director: Prof. Dr. m ed. M.P. Manns.

2002-2006: Residency, Department of Gastroenterology, Hepatology and Endocrinology, Medical School Hannover, Director: Prof. Dr. m ed. M.P. Manns

2001-2004, Research fellow in the laboratory of PD Dr. med. 2005 K.L. Rudolph, Department of Gastroenterology,

Hepatology and Endocrinology, Medical School Hannover.

2004 Research fellow in the laboratory of Prof. Dr. med. B. Schlegelberger, Institute of Cell- and

Molecularpathology, Medical School Hannover.2006-2008 Post Doctoral Fellowship from the Deutsche

Forschungsgemeinschaft, Prof. N. Bardeesy, MGH Cancer Center, Harvard Medical School, Boston, MA ,USA.

since 10/2008: Resident physician and Group leader, Department of Gastroenterology, Hepatology and Endocrinology, Medical School Hannover,Director: Prof. Dr. med. M.P. Manns.

Major research interests:GI-Cancer; pancreatic ductal adenocarcinoma, hepatocellular carcinoma, cholangiocellular carcinoma.Cancer treatment. Cancer stem cells.Notch signaling and JAK/STAT pathway.

Selected Publications:Plentz RR, et al Gastroenterology, 136:1741-1749; 2009.Faca VM,…Plentz RR, et. al. PLoS Med 2008 Juni 10;5 (6): e123.Plentz RR, et al. Hepatology 2007 April 45(4):968-976.Plentz RR, et al. Hepatology. 2005 September 42 (3): 522-526.Plentz RR, et al. Hepatology. 2004 Juli 40 (1): 80-6.Plentz RR, et al. GUT. 2003 Sep;52(9):1304-7.

First name:Ruben

Last name:Plentz

Acad. Title:Dr. med.

Address:OE 6810HannoverMedical School

Phone and e-mail:+49 511 532 3899

[email protected]

Department and function:Associate Professor, Virology

Education:2000 PhD in Biology, Friedrich-Alexander-University

Erlangen-Nürnberg2004 Habilitation in Virology, Friedrich-Alexander-

Universität Erlangen-Nürnberg

Positions:2000-2003: Postdoc at the University of Pennsylvania, Philadelphia,

USA2003-2007: Head of a DFG-Nachwuchsgruppe, Institute for Clinical

and Molecular Virology, Friedrich-Alexander-University Erlangen-Nürnberg

2007 - recent: Professor for Experimental Virology, Institute of Virology, Hannover Medical School

Major research interests:Cellular entry of HIV and (re)emerging virusesRole of cellular lectins in viral infectionsAssembly of HIV and its inhibition

Selected Publications:Hofmann H., Pyrc K., van der Hoek L., Geier M., Berkhout B., Pöhlmann S. Proc Natl Acad Sci U S A. 2005; 102:7988-93.Marzi A., Akhavan A., Simmons G., Gramberg T., Hofmann H., Bates P., LingappaV.R., Pöhlmann S. J. Virol. 2006; 80:6305-17. Suzuki-Inoue K., Fuller G.L., Garcia A., Eble J.A., Pöhlmann S., Inoue O., Gartner T.K., Hughan S.C., Pearce A.C., Laing G.D., Theakston R.D., Schweighoffer E., Zitzmann N., Morita T., Tybulewcz V.L., Ozaki Y., Watson S.P. Blood 2006; 107:542-9.Marzi A., Möller P., Hanna S.L., Harrer T., Eisemann J., Steinkasserer A., Becker S., Baribaud F., Pöhlmann S. J. Infect. Dis. 2007; 196:S237-S246 Münch J., Ständker L., Adermann K., Schulz A., Schindler M., Chinnadurai R., Pöhlmann S., Chaipan C., Biet T., Peters T., Meyer B., Wilhelm D., Lu H., Jing W., Jiang S., Forssmann W.G., Kirchhoff F. Cell 2007; 129:263-75.Powlesland A.S., Fisch T., Taylor M.E., Smith D.F., Tissot B., Dell A., Pöhlmann S., Drickamer K. J. Biol. Chem. 2008; 283:593-602 Chaipan C., Kobasa D., Bertram S., Glowacka I., Steffen I., Solomon Tsegaye T., Takeda M., Bugge T., Kim S., Park Y., Marzi A., Pöhlmann S. J. Virol. Im Druck

First name:Stefan

Last name:Pöhlmann




Further information:www99.mh-hannover.de/institute/virologie/home.html

Department and function:Specialist in Allergy and Dermatology (Dept. of Dermatology and Allergology)

Education:1999 MD, thesis: Programmed cell death of eosinophils

Hannover Medical School2004 Specialist of Dermatology2006 Specialist of Allergy

Positions:1999-2000: Post Doc, Dept. of Clinical Chemistry and Molecular

Diagnostics, Medical University of Marburg2001-recent: Lecturer, Dept. of Dermatology and Allergology, MHH2004-recent: Research group leader, Dept. of Dermatology and

Allergology, MHH

Major research interests:Neuroimmune interactions in allergic inflammation

Pathomechanisms of skin inflammation and pruritus

Selected Publications:Raap U, Schmid-Ott G, Bruder M, Wichmann K et al. J Allergy Clin Immunol2008; in press Raap U Wichmann K, Bruder M, Ständer S et al. J Allergy Clin Immunol2008; 122(2):421-3.Raap U, Wardlaw AJ. Exp Dermatol 2008; 17(9):731-8Raap U, Fokkens WJ, Bruder M, Hoogsteden H et al. Allergy 2008: 63(4):468-75.Raap U, Werfel T, Goltz C, Deneka N et al. Allergy 2006; 61(12):1416-8.Raap U, Goltz C, Deneka N, Bruder M et al. J Allergy Clin Immunol 2005; 115(6): 1268-75.Raap U, Brzoska T, Sohl S, Päth G et al. J Immunol 2003; 171(3): 353-9.

First name:Ulrike

Last name:Raap

Acad. Title:Dr. med.



Further information:www.hautklinik-linden.de

Department and function:Department of Cellular ChemistryJunior Professor

Education:1994 PhD in Biochemistry at Lille Universiy, France

Positions:1995-1996: Postdoctoral position at University College London, UK1997-1999: Postdoctoral position at University of Dundee, UK2000: Maternity break2001: Marie Curie Fellow at Wageningen Research Center,

The Netherlands2002: Research Scientist, Cellular Chemistry, Hannover

Medical School2003- present: Junior Professor in Parasitology

Cellular Chemistry, Hannover Medical School

Major research interests:Analysis of the glycosylation pathways of eukaryotic pathogenssuch as the parasite Leishmania major and the fungus AspergillusfumigatusGalactofuranose metabolism; Nucleotide sugar transportersDesign and testing of drug leads in collaboration with other laboratories

Selected Publications:Ashikov A, Routier FH, Fuhlrott J, Helmus Y, Wild M, Gerardy-Schahn R, Bakker H. J Biol Chem 2005; 280(29), 27230-27235 Higson AP, Ross AJ, Tsvetkov YE, Routier FH, Sizova OV, Ferguson MA, NikolaevAV. Chemistry 2005, 11 (7), 2019-2030.Routier FH, Bakker H, Oelmann S, Jordi W, Lommen A, Gerardy-Schahn R, Bosch D. Glycobiology 2005: 15(2), 193-201.Tiralongo J, Ashikov A, Routier FH, Eckhardt M, Bakker H, Gerardy-Schahn R, von Itzstein M. Glycobiology 2006; 16(1), 73-81Bakker H, Kleczka B, Gerardy-Schahn R, Routier FH. Biol Chem 2005;386(7), 657-661.Kleczka B, Lamerz AC, van Zandbergen G, Wenzel A, Gerardy-Schahn R, Wiese M, Routier FH. J Biol Chem. 2007; 282(14):10498-505.Bakker H, Routier F, Ashikov A, Neumann D, Bosch D, Gerardy-Schahn R. Carbohydr Res. 2008;343(12):2148-52. Schmalhorst PS, Krappmann S, Vervecken W, Rohde M, Müller M, Braus GH, Contreras R, Braun A, Bakker H, Routier FH. Eukaryot Cell. 2008;7(8):1268-77.

First name:Françoise

Last name:Routier




Further information:www.mh-hannover.de/zellulaere_ chemie.html

Department and function:Former Department of Gastroenterology, Team LeaderNow Professor at University Clinics of Ulm

Education:1997 Medical Doctor, Georg-August-University Göttingen2003 Habilitation in Experimental Gastroenterolgy, MHH

Positions:1998-2000: Postdoc with RA DePinho:

1. Albert-Einstein-college of Medicine, Bronx, New York2. Dana Faber Cancer Institute, Boston, MA

2001: Research Group Leader on Senescence, Aging and Carcinogenesis funded by the Emmy-Noether-Program

Major research interests:1. Exploring the role of telomere shortening in A) Senescence, Aging, and Regeneration and B) Induction of chromosomal instability and Cancer2. Identification of organ and tissue specific Aging Markers3. Exploring new model organisms for aging research

Selected Publications:Wiemann SU, Satyanarayana A, Buer J, Kamino K, et al. Oncogene 2005; 24(9):1501-9.Lechel A, Satyanarayana A, J u Z, Plentz RR, et al. EMBO Rep. 2005; 6(3):275-81Schaetzlein S, Rudolph KL. Reprod Fertil Dev. 2005;17(1-2):85-96.Plentz RR, Lankisch TO, Basturk M, Muller CC, Kirchhoff T, Gebel M, et al. J Gastroenterol Hepatol. 2005; 20(7):1134-6.Plentz RR, Tillmann HL, Kubicka S, Bleck JS, Gebel M, Manns MP, Rudolph KL. J Gastroenterol Hepatol. 2005; 20(9):1422-8.Djojosubroto MW, Chin AC, Go N, Schaetzlein S, Manns MP, Gryaznov S, Harley CB, Rudolph KL. Hepatology. 2005; 42(5):1127-36.Choudhury AR, Ju Z, Djojosubroto MW, Schienke A, Lechel A, Schaetzlein S, Jiang H, Stepczynska A, et al. Nat Genet. 2007;39(1):99-105. Plentz RR, Park YN, Lechel A, Kim H, Nellessen F, Langkopf BH, Wilkens L, et al. Hepatology. 2007;45(4):968-76.Lechel A, Holstege H, Begus Y, Schienke A, Kamino K, Lehmann U, Kubicka S, et al. Gastroenterology. 2007;132(4):1465-75.Ju Z, Jiang H, Jaworski M, Rathinam C, Gompf A, Klein C, Trumpp A, Rudolph KL. Nat Med. 2007;13(6):742-7. Schaetzlein S, Kodandaramireddy NR, Ju Z, Lechel A, Stepczynska A, Lilli DR, Clark AB, et al. Cell. 2007;130(5):863-77.Lechel A, Rudolph KL. Gastroenterology. 2008 Mar;134(3):875-8Jiang H, Schiffer E, Song Z, Wang J, Zürbig P, Thedieck K, et al. Proc Natl Acad Sci U S A. 2008;105(32):11299-304. Nalapareddy K, Jiang H, Guachalla Gutierrez LM, Rudolph KL. Exp Gerontol. 2008; 43(11):998-1004.Guachalla LM, Rudolph KL. Hepatology. 2009;49(1):330-2.

First name:K. Lenhard

Last name:Rudolph


Address:University of Ulm


Department and function:Pediatric Hematology/Oncology, and Blood Cell TransplantationOberarzt

Education:1995: MD Friedrich-Alexander-University Erlangen-Nürnberg2005: Habilitation in Pediatrics, MHH

Positions:1995-1999: Pediatric Residency, Friedrich-Schiller-University, Jena

Max-Planck-Institute for Experimental Hematostaseology, Jena

1999-2003: Clinical Fellow, Pediatric Hematology,Oncology, and Blood Cell Transplantation, University of Minnesota

2003-recent: Oberarzt Pediatric Hematology/Oncology, MHH Experimental Blood Stem Cell Transplantation, Transplantation Research Center, MHH

Major research interests:1. Adoptive Immunotherapy in allogeneic blood cell transplantation2. Experimental models for graft-versus-host-disease and graft-versus tumor-effects3. Development of “smart contrast agents”, molecular imaging

Selected Publications:Sauer M, Ericson M, Weigel B, Herron M, Angela Panoskaltisis-Mortari, Kren B, Levine B, Serody J, June C, Taylor P, Blazar B. Cancer Res. 2004;64(11):3914-21.Ghosh A, Wolenski M, Klein C, Welte K, Blazar BR, Sauer M. J Immunotherapy2008;31(2):121-31. Ghosh A, Koestner W, Hapke M, Schlaphoff V, Langer F, Baumann R, Koenecke C, Cornberg M, Welte K, Blazar B, Sauer M. Blood. 2009 Jan 30. [Epub ahead of print]

First name:Martin

Last name:Sauer

Acad. Title:PD Dr.



Department and function:Group Leader Junior Research Group Hematopoietic Cell Therapy(Department of Experimental Hematology), REBIRTH ExcellenceCluster

Education:1995-2001: MD, University of Hamburg2002-2005: PhD Program Molecular Medicine, HBRS Hannover

Positions:1996-2001: Subinternships and research fellowships at UCSF,

UCSD, Scripps Research Institute, UT SouthwesternMedical School, Childrens Hospital Zürich and LimbeProvincial Hospital (Cameroon). Doctorate student atHeinrich-Pette Institute for Immunology and Virology (Hamburg).

2002-2003: Pediatric resident, Childrens Hospital, Hannover Medical School (MHH)

Since 2002: Department of Experimental Hematology (Prof. C. Baum), MHH

Since 2007: Group Leader Junior Research Group “Hematopoietic Cell Therapy”, REBIRTH Excellence Cluster, MHH

Major research interests:Molecular medicine and development of gene vectors for clinical gene therapy of inherited and acquired diseases. Retrovirology. Modern Applications of Biotechnology. Gene Expression in mammalian cells.

Selected Publications:Schambach A, Baum C. Clinical application of lentiviral vectors – concepts and practice. Curr Gene Ther. 2008 Dec;8(6):474-82.Thornhill SI, Schambach A, Howe SJ, Baum C, Thrasher AJ et al. Self-inactivating Gammaretroviral Vectors for Gene Therapy of X-linked Severe Combined Immunodeficiency. Mol Ther. 2008 Mar;16(3):590-8.Schambach A, Galla M, Maetzig T, Loew R, Baum C. Improving transcriptional termination of self-inactivating gammaretroviral and lentiviral vectors. Mol Ther. 2007 Jun;15(6):1167-73. Schambach A, Schiedlmeier B, Kühlcke K, Verstegen M, Margison GP, Li Z, von Laer D, Baum C et al. Towards hematopoietic stem-cell mediated protection against infection with human immunodeficiency virus. Gene Ther 2006, 13(13):1037-47. Schambach A, Bohne J, Chandra S, Will E, Margison GP, Williams DA, Baum C.Equal potency of gammaretroviral and lentiviral SIN vectors for expression of O6-methylguanine-DNA-methyltransferase in bone marrow cells. Mol Ther. 2006. Feb;13(2):391-400.

First name:Axel

Last name:Schambach

Acad. Title:Dr. med., PhD



Further information:www.eh.mh-hannover.de

Department and function:Junior Professor of Molecular Hematology

Education:1997 PhD in Chemistry (Biological Chemistry), Johann

Wolfgang Goethe-University in Frankfurt/Main2002 Habilitation in Molecular Biology, Hannover Medical

School

Positions:1997-1998: Post-doc at the Beckman Research Institute of the City

of Hope, Dept. of Molecular Biology1998-2002 Post-doc at the Hannover Medical School, Dept. of

Hematology and Oncology2002-current: Junior Professor of Molecular Hematology at the

Hannover Medical School, Dept. of Hematology and Oncology

Major research interests:Gene silencing mediated by RNA interference (RNAi): functionalgenomics and therapeutic optionsLentiviral gene transfer into hematopoietic stem and precursor cells

Selected Publications:Scherr M., Battmer K., Ganser A., Eder M. Cell Cycle 2003; 2: 251-257.Scherr M., Battmer K., Winkler T., Heidenreich O., Ganser A., Eder M. Blood 2003;101:1566-1569.Scherr M., Battmer K., Dallmann I., Ganser A., Eder M. Oligonucleotides 2003; 13: 353-363.Scherr M., Battmer K., Schultheis B., Ganser A., Eder M. Gene Ther 2005; 12: 12-21.Eder M, Scherr M. N Engl J Med. 2005; 352(23):2446-8.Scherr M, Chaturvedi A, Battmer K, Dallmann I, Schultheis B, Ganser A, Eder M. Blood. 2006;107(8):3279-87.Venturini L, Eder M, Scherr M. J Biomed Biotechnol. 2006;2006(4):87340.Venturini L, Battmer K, Castoldi M, Schultheis B, Hochhaus A, Muckenthaler MU, Ganser A, Eder M, Scherr M. Blood. 2007;109(10):4399-405.Chaturvedi A, Battmer K, Schaefer D, Ganser A, Eder M, Scherr M. Oligonucleotides. 2007;17(1):22-34.Scherr M, Venturini L, Battmer K, Schaller-Schoenitz M, Schaefer D, Dallmann I, Ganser A, Eder M. Nucleic Acids Res. 2007;35(22):e149.Scherr M, Venturini L, Eder M. Methods Mol Biol. 2009;506:207-19.Nagel S, Venturini L, Przybylski GK, Grabarczyk P, Schmidt CA, Meyer C, Drexler HG, Macleod RA, Scherr M. Leuk Lymphoma. 2009;50(1):101-8.

First name:Michaela

Last name:Scherr





Department and function:Professor, Cardiology and Angiology

Education:1984-1990 Medical School, Albert Ludwigs

University Freiburg i. Br.1987-1990 Doctoral thesis: Role of the Renin-

Angiotensin System in Experimental Heart Failure.1992-1993 Clinical Residency, Dept. of Cardiology,

Freiburg, University Hospital1993-1996 Postdoc, Dept. Of Experimental

Pathology, EMORY University Atlanta, USA.1996- Dept. Of Cardiology and Angiology, MHH

Positions:1992-1993 Clincial Residency1993-1996 Post-doc1996-1999 Clinical Residency1999-2001 Research Associatesince 2001 Assistant Prof. of Medicine

Major research interests:Vascular biology and Signal transduction of G-Protein coupledreceptors. Experimental and clinical atherosclerosis research

Selected Publications:Luchtefeld M, Grote K, Grothusen C, Bley S, Bandlow N, Selle T, Struber M, Haverich A, Bavendiek U, Drexler H, Schieffer B. Biochem Biophys ResCommun. 2005; 328(1):183-8.Grothusen C, Bley S, Selle T, Luchtefeld M, Grote K, Tietge UJ, Drexler H, Schieffer B. Atherosclerosis. 2005; 182(1):57-69.Grote K, Luchtefeld M, Schieffer B. Vascul Pharmacol. 2005;43(5):357-63.Grote K, Ortmann M, Salguero G, Doerries C, Landmesser U, Luchtefeld M, Brandes RP, Gwinner W, Tschernig T, Brabant EG, Klos A, Schaefer A, DrexlerH, Schieffer B. Cardiovasc Res. 2006 Aug 1;71(3):596-605.Luchtefeld M, Bandlow N, Tietge UJ, Grote K, Pfeilschifter J, Kaszkin M, Beck S, Drexler H, Schieffer B. Atherosclerosis 2007;194(1):62-70.Grote K, Salguero G, Ballmaier M, Dangers M, Drexler H, Schieffer B. Blood. 2007;110(3):877-85Luchtefeld M, Schunkert H, Stoll M, Selle T, Lorier R, Grote K, et al. J Exp Med. 2007;204(8):1935-44.Salguero G, Akin E, Templin C, Kotlarz D, Doerries C, Landmesser U, Grote K, Schieffer B. J Hypertens. 2008;26(2):257-68. Divchev D, Grothusen C, Luchtefeld M, Thoenes M, Onono F, Koch R, Drexler H, Schieffer B. Eur Heart J. 2008;29(16):1956-65.

First name:Bernhard

Last name:Schieffer



Phone and e-mail:++49-511-532 4666++49-511-532 [email protected]

Further information:www.mh-hannover.de/ kardiologie.html

Department and function:Director, Cell and Molecular Pathology

Education:1975-1982 Studied medicine at the Ludwig Maximilian University

in Munich and the Christian Albrecht University of Kiel

Positions:1983-2000 Assistant, University Lecturer, then Professor at the

Institute of Human Genetics, University of Kiel1987-2000 Deputy Director of the Institute of Human Genetics,

University of Kiel2001- Director of the Institute of Cell and Molecular

Pathology, Hannover Medical School

Major research interests:My main interests are tumor genetics, with particular emphasis on thedissection of tumorigenesis, development of new diagnostic tools, and on genetic counseling in hereditary cancer syndromes.

Selected Publications:Rudolph C, Liehr T, Steinemann D, Emura M, Daibata M, Matsuo Y, et al. CytogenetGenome Res. 2006;112(3-4):213-21.Staal FJ, Cario G, Cazzaniga G, Haferlach T, et al. Leukemia. 2006;20(8):1385-92.Balakrishnan A, von Neuhoff N, Rudolph C, Kamphues K, et al. Genes Chromosomes Cancer. 2006;45(10):883-92Rudolph C, Bittner C, Feller AC, Merz H, Schlegelberger B. Cytogenet Genome Res. 2006;114(3-4):292-5.Gohring G, Hanke C, Kratz C, Kontny U, et al. Ann Hematol. 2006;85(12):883-5.Gadzicki D, Baumer A, Wey E, Happel CM, et al. Ann Hum Genet. 2006;70(Pt 6):958-64.Ripperger T, von Neuhoff N, Kamphues K, Emura M, et al. Haematologica. 2007; 92(4):460-8.Göhring G, Karow A, Steinemann D, Wilkens L, et al. Ann Hematol. 2007; 86(10):733-9.Göhring G, Erlacher M, van Buiren M, Jüttner E, et al. Cancer Genet Cytogenet. 2007; 179(2):162-4.Steinemann D, Cario G, Stanulla M, Karawajew L, et al. Genes ChromosomesCancer. 2008 ;47(6):471-80. Ripperger T, Gadzicki D, Meindl A, Schlegelberger B. Eur J Hum Genet. 2008 Dec17. [Epub ahead of print]Rudolph C, Schlegelberger B. Methods Mol Biol. 2009;506:453-66.Gadzicki D, Schubert A, Fischer C, Milde S, Lehmann U, Steinemann D, Lück HJ, Kreipe H, Schlegelberger B. Cancer Genet Cytogenet. 2009;189(2):105-11.

First name:Brigitte

Last name:Schlegelberger

Acad. Title:Prof. Dr..



Further information:www.mh-hannover.de/zellpathologie.html

Department and function:Director, Clinics of Immunology and RheumatologyChairman of the MD/PhD Program

Education:1976 M.D., Medical School of the Rheinische Friedrich-

Wilhelms-Universität Bonn1977 Masters of Psychology, Rheinische Friedrich-Wilhelms-

Universität Bonn

Positions:1978-83 Instructor in Medicine, Medical School of the University

of Bonn1986-94 Associate Professor of Medicine and Immunology,

Hannover Medical School1995- Head, Professor of Medicine and Immunology, Dept.

Clinical Immunology and Rheumatology, MHH

Major research interests:Fc receptors, regulation and activation, role in pathogenesis of diseases; activation mechanisms of human natural killer cells; pathogenesis of vasculitis and chronic rheumatoid arthritis; immunotherapy (cytokinesand immunoglobulins); immunodeficiencies, AIDS - pathogenesis and treatment; clinical therapy studies

Selected Publications:Skokowa J, et al. J Immunol. 2005; 174(5):3041-50.Koch S, et al. Genes Immun. 2005; 6(5):445-7.Mobius U, et al. J Acquir Immune Defic Syndr. 2005; 39(2):174-80.Rihl M, et al. J Infect. 2005 Nov 4;Kumar V, et al. J Clin Invest. 2006; 116(2):512-20.Momot T, et al. J Rheumatol. 2006;33(5):1029.Kittner JM, et al. J Clin Immunol. 2006; 26(4):400-5.Konrad S, et al. Br J Haematol. 2006;134(3):345-7.Ansari AW, et al. Int Immunol. 2006;18(10):1443-51.Wendt K, et al. J Leukoc Biol. 2006; 80(6):1529-41.Kittner JM, et al. Ann Allergy Asthma Immunol. 2007 Mar;98(3):294-8.Stankov MV, et al. Antivir Ther. 2007;12(2):205-16.Werwitzke S, et al. Ann Rheum Dis. 2008;67(2):154-61.Wendt K, et al. Immunology. 2007;122(4):486-95. Ansari AW, et al. Clin Immunol. 2007;125(1):1-4. Witte T, et al. Ann N Y Acad Sci. 2007;1108:414-7.Kabalak G, et al. Ann N Y Acad Sci. 2007;1110:10-4.Werwitzke S, et al. Scand J Immunol. 2008;67(5):501-8.Stankov MV, Schmidt RE, et al. Antimicrob Agents Chemother. 2008;52(8):2882-9. Moenkemeyer M, Schmidt RE, et al. J Med Virol. 2008;80(11):1933-40.

First name:Reinhold Ernst

Last name:Schmidt





Department and function:Director, Human Genetics

Education:1966-1973 Universities of Freiburg and Basel, Medicine

Positions: 1988-1990 Professor of Human Genetics, Berlin1990- Professor of Human Genetics, Director and Chair,

MHH

Major research interests:Molecular Basis of Inherited Disease, Genetics of Behavior in Subhuman Primates, Structure and Ethics of Genetic Service Provision

Selected Publications:Stuhrmann M, Strassburg C, Schmidtke J. Eur J Hum Genet. 2005; 13(1):69-78Krawczak M, Trefilov A, Berard J, Bercovitch F, et al. Biol Reprod. 2005; 72(5):1109-13.Singh KK, Schmidtke J. Immunogenetics. 2005; 57(3-4):289-92.Skawran B, Schubert S, Dechend F, Vervoorts J, Nayernia K, Luscher B, Schmidtke J. Mol Cell Biochem. 2005; 276(1-2):159-67.Singh KK, Ristau S, Dawson WW, Krawczak M, Schmidtke J. Exp Eye Res. 2005; 81(4):401-6.Trefilov A, Croucher PJ, Krawczak M, Schmidtke J. Twin Res Hum Genet. 2005; 8(6):551-2.Singh KK, Shukla PC, Rommel K, Schmidtke J, Arslan-Kirchner M. Eur J HumGenet. 2006;14(7):876-9.Karwacki V, Kovac J, Mauceri G, Backhaus A, Fohse L, Schmidtke J, Schubert S.Genomics. 2006;88(1):65-73.Singh KK, Rommel K, Mishra A, Karck M, Haverich A, Schmidtke J, Arslan-Kirchner M. Hum Mutat. 2006;27(8):770-7.Stuhrmann M, Nippert I, Hoy L, Schmidtke J. Clin Genet. 2006;70(1):73-7.Singh KK, Elligsen D, Liersch R, Schubert S, Pabst B, Arslan-Kirchner M, Schmidtke J. J Mol Cell Cardiol. 2007;42(2):352-6.Singh KK, Dawson WW, Krawczak M, Schmidtke J. Vet Ophthalmol. 2007; 10(5):274-7.Singh KK, Shukla PC, Schmidtke J. Eur J Hum Genet. 2008;16(7):869-72.Schubert S, Kamino K, Böhm D, Adham I, Engel W, von Wasielewski R,et al.Biol Reprod. 2008;79(1):125-33. Singh KK, Krawczak M, Dawson WW, Schmidtke J. Exp Eye Res. 2008. [Epubahead of print]Stuhrmann M, Brakensiek K, Argyriou L, Boehm I, Hinderhofer K, Bauer I, et al.Eur J Hum Genet. 2008 Dec 3. [Epub ahead of print] Söylen B, Singh KK, Abuzainin A, Rommel K, Becker H, Arslan-Kirchner M, Schmidtke J. Clin Genet. 2009 Jan 20. [Epub ahead of print]

First name:

Jörg

Last name:

Schmidtke


Address: OE 6300Hannover Medical School


Further information:www.human-genetik.net

Department and function:Director, Virology

Education:1980 MD Mainz1986 Habilitation Innsbruck

Positions:1996 MRCPath, London, 2003 FRCPath, London, 2004- Virology, MHH

Major research interests:Kaposi‘s sarcoma – associated herpesvirus/human herpesvirus 8

Selected Publications:Henke-Gendo C, Schulz TF, Hoeper MM. N Engl J Med. 2004; 350(2):194-5Henke-Gendo C, Schulz TF. Curr Opin Infect Dis. 2004; 17(1):53-7Dedicoat M, Newton R, Alkharsah KR, Sheldon J, et al. J Infect Dis. 2004; 190(6):1068Viejo-Borbolla A, Pizzato M, Blair ED, Schulz TF. Virus Res. 2005;108(1-2):45-55.Viejo-Borbolla A, Thomas P, Blair ED, Schulz TF. J Gen Virol. 2005;86:2469-80.Henke-Gendo C, Mengel M, Hoeper MM, Alkharsah K, Schulz TF. Am J Respir CritCare Med. 2005; 172(12):1581-5.Viejo-Borbolla A, Ottinger M, Bruning E, Burger A, Konig R, Kati E, Sheldon JA, Schulz TF. J Virol. 2005; 79(21):13618-29.Alkharsah KR, Dedicoat M, Deluca DS, Schulz TF, Blasczyk R. Tissue Antigens. 2006; 67(2):170-2Ottinger M, Christalla T, Nathan K, Brinkmann MM, Viejo-Borbolla A, Schulz TF.J Virol. 2006;80(21):10772-86.Barozzi P, Bosco R, Vallerini D, Potenza L, Torelli G, Luppi M, Facchetti F, GuaraldiG, Schulz TF. Transplantation. 2006;82(6):851-2.Brinkmann MM, Pietrek M, Dittrich-Breiholz O, Kracht M, Schulz TF. J Virol. 2007; 81(1):42-58.Alkharsah KR, Dedicoat M, Blasczyk R, Newton R, Schulz TF. J Infect Dis. 2007; 195(6):809-16. Wang L, Brinkmann MM, Pietrek M, Ottinger M, Dittrich-Breiholz O, Kracht M, Schulz TF. J Gen Virol. 2007;88(Pt 6):1698-707.Mattner F, Bitz F, Goedecke M, Viertel A, Kuhn S, Gastmeier P, et al. Infection. 2007;35(4):219-24.Schulz TF, Cordes S. Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2091-2. Ottinger M, Pliquet D, Christalla T, Frank R, Stewart JP, Schulz TF. J Virol. 2009 Feb 25. [Epub ahead of print]

First name:

Thomas F.

Last name:Schulz

Acad. Title:Prof. Dr. med., FRCPath



Department and function:Group Leader, Transplant Laboratory

Education:1983 Degree of „Diplom-Biologe“ (Masters Degree in

Biology), University of Braunschweig

1987 Degree of „Dr.rer.nat.“ (PhD), University of Hannover

1994 Habilitation; Venia legendi for Immunology, Hannover Medical School (MHH)

Positions:1983-1987 Research Assistant, MHH

1987-1990 Research Associate, MHH

1990-1991 Fellowship of the German Research Council (DFG), National Jewish Center for Immunology, Denver

1991- Group leader, Transplant Laboratory, MHH

1999- Professor of Immunology

Major research interests:Transplant Immunology/Xenotransplantation: Analysis of human anti-pig T cell responses, development of immunomodulatory antibodies, immunological monitoring of transplant recipients.Analysis of T cell activation in the human: Signal transduction, role of cell surface molecules (CD28, CD45), CD45 polymorphisms.

Selected Publications:Siefken R, Klein-Heßling S, Serfling E, Kurrle R, Schwinzer R. J Immunol 1998; 161:1645-1651 Jacobsen M, Schweer D, Ziegler A, et al. Nature Gen 2000; 26:495-499Niemann H, Verhoeyen E, Wonigeit K et al. Transplantation 2001; 72:1898-906 Dulat H, von Grumbkow C, Baars W, Schröder N, Wonigeit K, Schwinzer R. Eur J Immunol 2001; 31: 2217-2226Schwinzer R, Witte T, Hundrieser J, et al. Genes Immun 2003; 4:168-169Bedke T, Baars W, Schwinzer R Ann Transplant. 2003; 8(3):35-8Do HT, Baars W, Schwinzer R. Transplant Proc. 2005; 37(1):51-2.Do HT, Baars W, Borns K, Windhagen A, Schwinzer R. J Immunol. 2006; 176(2):931-8.Windhagen A, Sönmez D, Hornig-Do HT, Kalinowsky A, Schwinzer R. Clin Exp Immunol. 2007;150(3):509-17.

First name:Reinhard

Last name:Schwinzer

Acad. Title:Prof. Dr.rer.nat.



Further information:http://www.mh-hannover.de/ach.html

Department and function:Gastroenterology, Hepatology & EndocrinologyAttending in medicine and GI, principal investigator

Education:1977 -1985 Study of Medicine at the Ludwig-

Maximilian‘s University, Munich1985 Doctoral thesis2000 Venia legendi for international medicine

Positions:1985 - 1987 Postdoc, Dept. of Pharmacology, MHH1987 – 1988 Postdoc., Dig. Dis Center, Beth Israel Hospital, Boston1988 – 1995 Resident in Internal medicine and GI, Technical

University of Munich1995 - 2002 Attending, GI Division, Eberhard-Karls University,

Tübingen

Major research interests:1.Structure-function relationsships and protein-protein interactions in the regulation of the transport proteins for intestinal salt absorption and anion secretion.2.Mechanisms of volume regulation in gastrointestinal cells.3.Adaptive mechanisms in the gastrointestinal tract after selectiveknockout of transport and regulator proteins which are important in gastrointestinal salt and nutrient transport.

Selected publications:Bachmann O, Riederer B, Rossmann H, Groos S, et al. Am J Physiol GastrointestLiver Physiol. 2004; 287(1):G125-33.Schwab A, Rossmann H, Klein M, Dieterich P, Gassner B, Neff C, Stock C, Seidler U. J Physiol. 2005;568(Pt 2):445-58Tuo B, Riederer B, Wang Z, Colledge WH, Soleimani M, Seidler U. Gastroenterology. 2006;130(2):349-58Bachmann O, Reichelt D, Tuo B, Manns MP, Seidler U. Am J Physiol GastrointestLiver Physiol. 2006;291(4):G650-7.Bachmann O, Heinzmann A, Mack A, Manns MP, Seidler UE. Am J PhysiolGastrointest Liver Physiol. 2006 Nov 9; [Epub ahead of print]Bachmann O, Heinzmann A, Mack A, Manns MP, Seidler U. Am J PhysiolGastrointest Liver Physiol. 2007;292(3):G711-7.Cinar A, Chen M, Riederer B, Bachmann O, Wiemann M, Manns M, Kocher O, Seidler U. J Physiol. 2007;581(Pt 3):1235-46. Tuo BG, Wen GR, Seidler U. Am J Physiol Gastrointest Liver Physiol. 2007; 293(1):G279-87.

First name:Ursula

Last name:Seidler




Further information:http://www99.mh-hannover.de/kliniken/gastro/seidler_/agseidler_d.htm

Department and function:Institute for Transfusion Medicine

Education:1996 MD, Friedrich-Alexander-University

Erlangen2002 Medical specialist in transfusion medicine2003 W1-Professor for molecular immunohematology

Positions:1996-1998: Intern, Clinic I for Internal Medicine, Clinical Center

Fuerth1998-2001: Resident, Department of Hematology, Oncology and

Blood Bank, Humboldt-University Berlin1997-2000: Resourch Group Leader, Institute for Transfusion

Medicine, Hanover Medical School, Hanover, Germany2003-recent: W1-Professor, Institute for Transfusion Medicine,

Hanover Medical School, Hanover, Germany

Major research interests:Molecular biology of erythrocyte proteinsDecreasing Immunogenicity of Progenitor Cells by Regulating MHC Expression

Selected Publications:Seltsam A, Hallensleben M, Kollmann A, Blasczyk R. Blood 2003; 102: 3035-42.Eiz-Vesper B, Seltsam A, Blasczyk R. Transfusion 2005; 45:960-8.Seltsam A, Das Gupta C, Wagner FF, Blasczyk R. Transfusion. 2005;45:359-65.Wagner FF, Blasczyk R, Seltsam A. Transfusion 2005;45:1331-4.Figueiredo C, Seltsam A, Blasczyk R. J Mol Med. 2006;84(5):425-37.Seltsam A, Das Gupta C, Bade-Doeding C, Blasczyk R. Transfusion. 2006;46(3):434-40.Figueiredo C, Horn PA, Blasczyk R, Seltsam A. Transfusion. 2007;47(1):18-27.Seltsam A, Strigens S, Levene C, Yahalom V, Moulds M, Moulds JJ, Hustinx H, Weisbach V, Figueroa D, Bade-Doeding C, Deluca DS, Blasczyk R. Transfusion. 2007 Jan;47(1):133-46.Seltsam A, Grüger D, Blasczyk R. Transfusion. 2007;47(9):1630-6.Seltsam A, Wagner FF, Grüger D, Gupta CD, Bade-Doeding C, Blasczyk R. Transfusion. 2007;47(12):2330-5. Seltsam A, Agaylan A, Grueger D, Meyer O, Blasczyk R, Salama A. Transfusion. 2008;48(4):731-4.Seltsam A, Agaylan A, Grueger D, Meyer O, Blasczyk R, Salama A. Transfusion. 2008;48(6):1151-5.Seltsam A, Grüger D, Just B, Figueiredo C, Gupta CD, Deluca DS, Blasczyk R. Transfusion. 2008;48(9):1898-905.

First name:Axel

Last name:Seltsam

Acad. Title:Prof. Dr.med.


Phone and e-mail:++49- 511- 532 6704

Further information:www99.mh-hannover.de/institute/transfusion/transfusionsmedizin/

Department and function:Assistant Professor, Virology

Education:1982 – 1988 University of Bonn, Biology1988 – 1989 Columbia University, New York, NY, USA

Immunology1989 - 1993 European Molecular Biology Laboratory, Heidelberg,

Cell Biology

Positions:1993 - 1997 Postdoc and Staff Scientist, Yale University,

New Haven, CT, USA, Dept. Cell Biology1997 – 2002 Group leader, Biochemistry Dept., MHH2002- Assistant Professor

Major research interests:Our group is interested in the cell biology of complex DNA viruses. How does a virus get access to a cell, disassemble to uncover its genome for replication, and how is – within a couple of hours – the viral program switched to virus assembly and egress? We have developed several in vivo and in vitro motility assays to analyse the cell biology of Herpes Simplex Virus and particularly the microtubule-mediated capsid transport by digital video microscopy. Using these assays, we characterize cytosolic host factors as well as structural viral proteins important in HSV1 entry and egress.

Selected Publications:Döhner, Wolfstein, Prank, Echeverri, Dujardin, Vallee, & Sodeik. Molecular Biology Cell 2002; 13:2795-2809.Mabit H, Nakano MY, Prank U, Saam B, Dohner K, et al. J Virol. 2002; 76(19):9962-71Sodeik B. J Cell Biol. 2002; 159(3):393-5.Marozin S, Prank U, Sodeik B. J Gen Virol. 2004; 85(Pt 4):775-86.Haas M, Siegert M, Schurmann A, Sodeik B, Wolfes H. Biochemistry. 2004; 43(25):8152-9.Dohner K, Sodeik B. Curr Top Microbiol Immunol. 2005;285:67-108.Wolfstein A, Nagel CH, Radtke K, Dohner K, Allan VJ, Sodeik B. Traffic. 2006; 7(2):227-37Radtke K, Dohner K, Sodeik B. Cell Microbiol. 2006; 8(3):387-400.Dohner K, Radtke K, Schmidt S, Sodeik B. J Virol. 2006;80(16):8211-24.Nagel CH, Döhner K, Fathollahy M, Strive T, Borst EM, Messerle M, Sodeik B. J Virol. 2008;82(6):3109-24.Maurer UE, Sodeik B, Grünewald K. Proc Natl Acad Sci U S A. 2008; 105(30):10559-64.

First name:Beate

Last name:Sodeik

Acad. Title:Prof. Dr. rer.nat.



Further information:http://www99.mh-hannover.de/institute/virologie/home.html

Department and function:Director of the Institute of Infection Immunology at TWINCORE

Education:1989-1995 Studies of Medicine, Universities of Mainz, Munich and

Stony Brook University, New York, USA1996 Doctor of Medicine (Dr. med.), Johannes Gutenberg-

Universität Mainz („magna cum laude“)1997 Final State Medical Examination (3. Teil der Ärztlichen

Prüfung und Approbation)2008 Habilitation in Medical Microbiology at Technische

Universität München2008 Board certification as Medical Microbiologist

(Facharztprüfung)

Positions:1996-1999 Clinical Fellow, Institute of Medical Microbiology,

Immunology and Hygiene – Laboratory of Prof. H. Wagner, Technical University of Munich

1999-2002 Howard Hughes Postdoctoral Fellow, Skirball Instituteof Biomolecular Medicine, New York University Medical Centre, New York, USA

2002-2008 Group Leader at the Institute of Medical Microbiology, Immunology and Hygiene – Technical University of Munich

2008-recent Full Professor (W3) of Infection Immunology and Director, Institute of Infection Immunology (Twincore), Hannover Medical School

Major research interests:Pattern recognition receptors (TLRs, CLRs)Dendritic Cells, Regulatory T CellsHost-Pathogen Interaction, Vaccination

Selected Publications:Schildknecht, A., S. Brauer, C. Brenner, K. Lahl, H. Schild, T. Sparwasser*, H. C. Probst*, and M. v. d. Broek*. 2010. PNAS 107(1):199-203. *(equally contributed)Kim, J., K. Lahl, S. Hori, C. Loddenkemper, A. Chaudhry, P. Deroos, A. Rudensky, and T. Sparwasser. 2009. J Immunol 183(12):7631-7634.Schaefer, M., N. Reiling, C. Fessler, J. Stephani, I. Taniuchi, F. Hatam, A. O. Yildirim, H. Fehrenbach, K. Walter, J. Ruland, H. Wagner, S. Ehlers, and T. Sparwasser. 2008. J Immunol 180:6836-6845.Lahl, K., C. Loddenkemper, C. Drouin, J. Freyer, J. Arnason, G. Eberl, A. Hamann, H. Wagner, J. Huehn, and T. Sparwasser. 2007. J Exp Med 204:57-63.Gross, O., A. Gewies, K. Finger, M. Schafer, T. Sparwasser, C. Peschel, I. Forster, and J. Ruland. 2006. Nature 442:651-656.

First name:Tim

Last name:Sparwasser


Address:OE 9653TWINCOREFeodor-Lynen-Str. 730625 Hannover


Further information:www.twincore.de

Department andfunction:Hematology Hemostasiology, Oncologyand Stem CellTransplantation

Group LeaderLymphatic Cell Therapy

Education:1993 PhD in Molecular Biology(Gene Expression),

EuropeanMolecular BiologyLaboratory (EMBL)and University of Heidelberg

2002 Habilitation in Geneticsand Molecular BiologyUniversity of Hamburg

Positions:1999-2003: Assistant Professor, Department of Pathology,

University of Southern California (USC),Los Angeles, CA, USA

2003-2007: Assistant Professor, Department of Medicine,Co-Director Molecular Vector Core,University of California Los Angeles (UCLA),Los Angeles, CA, USA

2007-recent: Lecturer (Privat Dozent) W2 ProfessorshipMedical School Hannover,Hannover, Germany

Major research interests:Genetic programming of hematopoietic precursors and stem cells for

clinical development of engineered cellular vaccinesfor cancerand chronic infectious diseases.

Rational development of gene transfer systems.

SelectedPublications:

.

- Kimura T., et al (2007). MolTher 15(7):1390-9.

.

- Koya R., et al (2007). Mol Ther 15(5):971-80.

- Koya, RC, et al (2004). Human Gene Therapy , 15:733-48.

- Stripecke , R., et al (2002) Leukemia, 16 (10): 1974-83.

- Koya R.C., et al (2002). Leukemia, ; 16 (9): 1645-1654.

First name:Renata

Last name:Stripecke

Acad. Title:Priv. Doz.

Address:OE 6860HannoverMedicalSchool


Further information:www.stripecke-lab.de

- Stripecke R. Methods Mol Biol. 2009;506:139-58.

Department and function:Professor, Human Genetics

Education:1980 – 1986 Free University Berlin, Medicine1988 MD1995 Specialist in Human Genetics2002 apl. Professorship

Positions:1987 Guestdoc, Cerrahpasha Medical Faculty,

Istanbul, Turky1988 – 1990 Postdoc, Inst. Humangenetics, FU BerlinSince 1991 Head of Molecular Diagnostics, Inst. Human

Genetics, Medical School Hannover

Major research interests:Molecular genetics of several monogenenic disorders like cysticfibrosis, haemochromatosis, morbus Osler, ataxia telangiectasia; neuro-and psychiatro-genetics, genetic screening

Selected Publications:Stuhrmann M, Strassburg C, Schmidtke J. Eur J Hum Genet. 2005; 13(1):69-78.Kuehl HK, Caselitz M, Hasenkamp S, Wagner S, El-Harith el-HA, Manns MP, Stuhrmann M. Hum Mutat. 2005; 25(3):320.Stuhrmann M, Hoy L, Nippert I, Schmidtke J. Genet Test. 2005;9(3):242-54.Hildebrand F, Pape HC, Griensven M, Meier S, Hasenkamp S, Krettek C, StuhrmannM. Shock. 2005;24(6):518-22.Stuhrmann M, Nippert I, Hoy L, Schmidtke J. Clin Genet. 2006;70(1):73-7El-Harith el-HA, Kuhnau W, Schmidtke J, Gadzicki D, Ahmed M, Krawczak M, Stuhrmann M. Eur J Med Genet. 2006;49(4):323-30.Metzger S, Bauer P, Tomiuk J, Laccone F, Didonato S, Gellera C, Mariotti C, Lange HW, et al. Hum Genet. 2006;120(2):285-92Mössner R, Müller-Vahl KR, Döring N, Stuhrmann M. Mol Psychiatry. 2007; 12(7):617-9.Goebel JC, Soergel P, Pruggmayer M, Mühlhaus K, Stuhrmann M, Scharf A. Arch Gynecol Obstet. 2008 Feb;277(2):155-60.Seifert J, Ossege S, Emrich HM, Schneider U, Stuhrmann M. Neurosci Lett. 2007; 426(1):29-33.Stuhrmann M, Hennies HC, Bukhari IA, Brakensiek K, Nürnberg G, Becker C,et al. Clin Genet. 2008;73(6):566-72.Brakensiek K, Frye-Boukhriss H, Mälzer M, Abramowicz M, Bahr MJ, von Beckerath N, et al. Clin Genet. 2008;74(2):171-7. El-Harith el-HA, Roesl C, Ballmaier M, Germeshausen M, Frye-Boukhriss H, von Neuhoff N, et al. Br J Haematol. 2009 Jan;144(2):185-94. Stuhrmann M, Brakensiek K, Argyriou L, Boehm I, Hinderhofer K, Bauer I, et al. EurJ Hum Genet. 2008 Dec 3. [Epub ahead of print]

First name:Manfred

Last name:Stuhrmann-Spangenberg




Further information:www.mh-hannover.de/humangenetik.html

Department and function:Director, Institute for Med. Microbiology and Hospital Epidemiology

Education:1988 Doctor of Medicine (Dr. med.), Ruhr-University Bochum1995 Habilitation in Medical Microbiology, Ruhr-University

Bochum

Positions:01/88-12/88 Clinical Fellow, Bernhard Nocht-Institute for Tropical

Medicine, Hamburg1989-1991: Research Associate, Department of Medical

Microbiology and Immunology, Ruhr-University Bochum

1991-1993: Research Fellow in the group of Dr. Agnès Labigne, Institut Pasteur, Paris

1993-1999: Research Fellow (-1995) and Assistant Professor,Department of Medical Microbiology and Immunology, Ruhr-University Bochum

1999-2003: Associate Professor and Deputy Chairman, Institute of Hygiene and Microbiology, University of Würzburg

since 2003: Full Professor of Medical Microbiology at MHH

Major research interests:Investigations into molecular pathogenesis, genetic variability,evolution, population genetics and molecular epidemiology of Helicobacter pylori. Analysis of pathogenicity mechanisms of Helicobacter hepaticus.

Selected PublicationsSuerbaum, S., J. Maynard Smith, K. Bapumia, G. Morelli, N. H. Smith, E. Kunstmann, I. Dyrek, M. Achtman. 1998. Proc. Natl. Acad. Sci. U.S.A. 95:12619-12624.Falush, D., C. Kraft, P. Correa, N. S. Taylor, J. G. Fox, M. Achtman, S. Suerbaum. 2001. Proc. Natl. Acad. Sci. U.S.A. 98:15056-15061.Suerbaum, S., P. Michetti. 2002. N. Engl. J. Med. 347:1175-1186Falush, D., T. Wirth, B. Linz, …, M. Achtman, S. Suerbaum. 2003. Science 299:1582-1585.Suerbaum, S., C. Josenhans, T. Sterzenbach, …, M. Frosch, J. G. Fox. 2003. Proc. Natl. Acad. Sci. U.S.A. 100:7901-7906.Schreiber, S., M. Stüben, C. Groll, P. Scheid, G. Hanauer, H.-O. Werling, C. Josenhans, S. Suerbaum. 2004. Proc. Natl. Acad. Sci. 101:5024-5029.Linz, B., F. Balloux*, Y. Moodley, …, S. Suerbaum*, M. Achtman*. 2007. Nature 445:915-918. * Corr. AuthorsSuerbaum, S., C. Josenhans. 2007. Nat. Rev. Microbiol. 5:441-452.Schwarz, S., G. Morelli, B. Kusecek, A. Manica, F. Balloux, R. J. Owen, D. Y. Graham, S. van der Merwe, M. Achtman, S. Suerbaum. 2008. PLoS Pathogens 4:e1000180.

First name:Sebastian

Last name:Suerbaum




Further information:www.mh-hannover.de/mikrobiologie/html

Department and function:Vice Chair and Director of Research, Dept. of Anesthesiology and Intensive Care Medicine

Education:1995 MD, Westf. Wilhelms-Universität, Münster

2003 Habilitation in Anesthesiology and Intensive CareMedicine, Wilhelms-Universität, Münster

Positions:1992-1994: Research Associate Stanford University, Falk

Cardiovascular Rersearch Center1995-2003: Resident at the Dept. for Anesthesiology, University

Hospital Münster1997-2000: Research Fellowship: Center for Molecular and Vascular Biology, Katholieke Universiteit Leuven, Belgium2003-2007: Attd. Anesthesiologist, Director of Research,

Dept. for Anesthesiology, University Hospital Münster2007 -recent: Professor of Anesthesiology, Vice Chair and Director of

Research Dept. of Anesthesiology and Intensive Care Medicine, MHH

Major research interests:Identification and analysis of adhesion molecule modulators as therapeutic targets to taper inflammatory response and adverse tissue remodelling after cardiovascular complications in perioperativemedicine.

Selected Publications:Conway EM, Van de Wouwer M, ..., Theilmeier G. (2002) Journal of Experimental Medicine; 196(5): 565-577

Theilmeier G, Michiels C, Spaepen E, Vreys I, Collen D, Vermylen J, Hoylaerts MF. Blood 2002; 99(12): 4486-93.

Jan Larmann J, Schmidt C, Gammelin H, Van Aken HK, Frenzel T, Lanckohr C, LoxM, Boese N, Jurk K, Theilmeier G. Anesthesiology 2005; 103: 1-6

Stegger L, Hoffmeier AN, Schäfers KP, Hermann S, Schober O, Schäfers M, Theilmeier G. J Nucl Med. 2006; 47(11):1837-44

Theilmeier G., Schmidt C., Herrmann J, Keul P, ... Chun J, Levkau B. Circulation2006; 114(13):1403

First name:Gregor

Last name:Theilmeier

Acad. Title:Univ.-Prof. Dr.



Further information:http://openwetware.org/wiki/Theilmeier_Lab

Department and function:Head, ‘Clinical Reasearch Group Pseudomonas‘

Education and positions:1971 - 1976 study of biochemistry1974 - 1981 study of medicine1979 Dr. rer.nat.1984 Dr. med.1991 habilitation1992 professorship

Major research interests:• Genomics• Molecular pathology of cystic fibrosis• Pseudomonas genomics

Selected Publications:Stanke F, Becker T, Cuppens H, Kumar V, Cassiman JJ, Jansen S, et al. Hum Genet. 2006;:1-13van Barneveld A, Stanke F, Ballmann M, Naim HY, Tummler B. Biochim BiophysActa. 2006;1762(4):393-7.Charizopoulou N, Wilke M, Dorsch M, Bot A, Jorna H, Jansen S, Stanke F, HedrichHJ, de Jonge HR, Tummler B. BMC Genet. 2006;7:18.Reva ON, Weinel C, Weinel M, Bohm K, Stjepandic D, Hoheisel JD, Tummler B. J Bacteriol. 2006;188(11):4079-92.Bragonzi A, Wiehlmann L, Klockgether J, Cramer N, Worlitzsch D, Doring G, Tummler B. Microbiology. 2006;152(Pt 11):3261-9.Klockgether J, Wurdemann D, Reva O, Wiehlmann L, Tummler B. J Bacteriol. 2006 Dec 28; [Epub ahead of print]Chang YS, Klockgether J, Tummler B. FEMS Microbiol Lett. 2007;270(2):201-6.Wiehlmann L, Wagner G, Cramer N, Siebert B, Gudowius P, Morales G, et al. ProcNatl Acad Sci U S A. 2007; 104(19):8101-6. Wiehlmann L, Munder A, Adams T, Juhas M, Kolmar H, Salunkhe P, Tümmler B. IntJ Med Microbiol. 2007;297(7-8):615-23. van Barneveld A, Stanke F, Claaß A, Ballmann M, Tümmler B. J Cyst Fibros. 2007 Aug 15; [Epub ahead of print]Würdemann D, Tümmler B. FEMS Microbiol Lett. 2007;275(2):244-9.Stanke F, Ballmann M, Bronsveld I, Dörk T, Gallati S, Laabs U, et al.. J Med Genet. 2008;45(1):47-54.Rakhimova E, Munder A, Wiehlmann L, Bredenbruch F, Tümmler B. PLoS ONE. 2008 Feb 27;3(2):e1685.Tóth B, Wilke M, Stanke F, Dorsch M, Jansen S, Wedekind D, et al. BMC Genet. 2008;9:28.Klockgether J, Würdemann D, Wiehlmann L, Tümmler B. Microbiology. 2008; 154(Pt 6):1599-604.Davenport CF, Wiehlmann L, Reva ON, Tümmler B. Environ Microbiol. 2009 Jan 21. [Epub ahead of print]Tümmler B, Stanke F, Bronsveld I, Veeze H, Ballmann M. Thorax. 2009;64(2):179-80.

First name:Burkhard

Last name:Tümmler

Acad. Title:Prof. Dr. Dr.



Further information:http://www99.mh-hannover.de/kliniken/kinderheilkunde/kfg/

Department and function: Director, Cell Biology

Education:1974: Diploma in Biology from the Free University Berlin1976: PhD obtained from the Free University Berlin1977-79: EMBO Fellow at the MRC Unit for Biophysics at

King‘s College in London, UK1979-82: Postdoctoral fellow (DFG) at the Biological

Laboratories at Harvard University (Cambridge, Ma)1982-84: Heisenberg-Fellow at the LMB in Cambridge (UK)

and the Max-Planck Institute for BiophysicalChemistry in Göttingen, Germany.

Positions:1986-92: Junior-Research group leader at the Max-Planck-

Institute for Biochemistry, Martinsried, Germany1992-1998: Associate Professor at the Dept. of pathology at

Washington University St. Louis, MOsince 1998: Professor for Cell Biology at MHH

Major research interests:Intracellular vesicular transport, functions of molecular chaperones

Selected Publications:Ungewickell, E., H. Ungewickell, et al. Nature 1995; 378: 632-635.Umeda, A., A. Meyerholz, et al. Eur J Cell Biol 2000; 79(5): 336-342.Scheele, U., C. Kalthoff, et al. J Biol Chem 2001; 276(39): 36131-36138.Kalthoff, C., S. Groos, et al. Mol Biol Cell 2002; 13(11): 4060-4073.Kalthoff, C., J. Alves, et al. J Biol Chem 2002; 277(10): 8209-8216.Scheele, U., J. Alves, et al. J Biol Chem. 2003; 278(28):25357-68.Hinrichsen, L., J. Harborth, et al. J Biol Chem. 2003; 278(46): 45160-70.Tsukada M, Prokscha A, Ungewickell E, Eichele G. J Biol Chem. 2005; 280(12):11361-8.Meyerholz A, Hinrichsen L, Groos S, Esk PC, Brandes G, Ungewickell EJ. Traffic. 2005; 6(12):1225-34.Hasse S, Ungewickell EJ, Groos S. Histochem Cell Biol. 2006;126(2):219-29Hinrichsen L, Meyerholz A, Groos S, Ungewickell EJ. Proc Natl Acad Sci U S A. 2006;103(23):8715-20.Duwel M, Ungewickell EJ. Mol Biol Cell. 2006;17(10):4513-25.

First name:Ernst

Last name:Ungewickell



Phone and e-mail: ++49-511- 532 [email protected]

Further information:www99.mh-hannover.de/institute/zellbiologie/

Department and function:Head, Central Institute for Biophysical and BiochemicalProcedures

Education:1968-1972 Chemistry, Technical University Braunschweig1972 – 1976 Dissertation, University Hannover

Positions:1973- Hannover Medical School

Major research interests:Protein nucleic acid and protein protein interactions Single strandedDNA binding proteins, analytical ultracentrifugation, biophysicalchemistry in solution

Selected Publications:Grazulis S, Deibert M, Rimseliene R, Skirgaila R, Sasnauskas G, et al. NucleicAcids Res 2002; 30(4):876-85Meyer S, Urbanke C, Wahle E.. Biochemistry 2002 ;41(19):6082-9Landwehr M, Curth U, Urbanke C. Biol Chem 2002; 383(9):1325-33 Schubert WD, Urbanke C, Ziehm T, Beier V, Machner MP,et al. Cell 2002; 111(6):825-36Witte G, Urbanke C, Curth U. Nucleic Acids Res. 2003; 31(15):4434-40Zaremba M, Urbanke C, Halford SE, Siksnys V J Mol Biol. 2004; 336(1):81-92Dreisewerd K, Rohlfing A, Spottke B, Urbanke C, Henkel W. Anal Chem. 2004; 76(13):3482-91Hansen T, Urbanke C, Schonheit P Extremophiles 2004; 8(6):507-12Maheswaran M, Urbanke C, Forchhammer K. J Biol Chem. 2004; 279(53):55202-10Yildiz O, Doi M, Yujnovsky I, Cardone L, Berndt A, Hennig S, Schulze S, Urbanke C, Sassone-Corsi P, Wolf E. Mol Cell. 2005; 17(1):69-82.Brasen C, Urbanke C, Schonheit P. FEBS Lett. 2005; 579(2):477-82.Urbanke C, Witte G, Curth U. Methods Mol Biol. 2005;305:101-14.Zaremba M, Sasnauskas G, Urbanke C, Siksnys V. J Mol Biol. 2006;363(4):800-12.Manelyte L, Urbanke C, Giron-Monzon L, Friedhoff P. Nucleic Acids Res. 2006;34(18):5270-9.Fedorov R, Witte G, Urbanke C, Manstein DJ, Curth U. Nucleic Acids Res. 2006;34(22):6708-17.Lübben M, Güldenhaupt J, Zoltner M, Deigweiher K, Haebel P, Urbanke C, Scheidig AJ. J Mol Biol. 2007;369(2):368-85.Gasiunas G, Sasnauskas G, Tamulaitis G, Urbanke C, Razaniene D, Siksnys V.Nucleic Acids Res. 2008;36(3):938-49.Arad G, Hendel A, Urbanke C, Curth U, Livneh Z. J Biol Chem. 2008; 283(13):8274-82.Jurkowska RZ, Anspach N, Urbanke C, Jia D, Reinhardt R, Nellen W, Cheng X, Jeltsch A. Nucleic Acids Res. 2008 Dec;36(21):6656-63.

First name:Claus

Last name:Urbanke





Department and function:Head of Division of Cell Biology and Immunology, HZI

Education:1980 PhD in Cell Biology, Max-Planck-Institute for

Biophysical Chemistry, Göttingen; University Bonn1988 Habilitation in Cell Biology, University Bonn

Positions:1980-1982: Postdoc, National Cancer Institute, Bethesda,

USA (supported by EMBO fellowship)1983-1989: Research Assistant, Dept. of Biochemistry and Cell

Biology, Max-Planck-Institute for Biophysical Chemistry, Göttingen

1989-1993: Research Assistant, Project Leader in Dept. of Microbiology, HZI, Braunschweig

1994-1997: Acting head of the Division of Cell Biology and Immunology, HZI, Braunschweig

Since 1997: Full Professor (C4) for Cell Biology and Immunology, Technical University Braunschweig;Head of the Division of Cell Biology and Immunology, HZI, Braunschweig

Major research interests:Analysis of mechanisms of host/pathogen interactions signalling to the actin cytoskeleton; actin dynamics and cell motility.

Selected Publications:Schubert, W.-D., Urbanke, C., Ziehm, T., Beier, V., Machner, M., Domann, E., Wehland, J., Chakraborty, T. & Heinz, D.W. Cell 2002; 111: 825-836.Steffen, A., Rottner, K., Ehinger, J., Innocenti, M., Scita, G., Wehland, J. , Stradal, T. E. EMBO J. 2004; 23(4):749-59Erck C, Peris L, Andrieux A, Meissirel C, Gruber AD, Vernet M, Schweitzer A, Saoudi Y, Pointu H, Bosc C, Salin PA, Job D, Wehland J. Proc Natl Acad Sci U S A. 2005; 102(22):7853-8.Dieterich G, Karst U, Fischer E, Wehland J, Jansch L. Nucleic Acids Res. 2006; 34(Database issue):D402-6.Jenzora A, Behrendt B, Small JV, Wehland J, Stradal TE. FEBS Lett. 2006; 580(12):455-63.Baumgartner M, Karst U, Gerstel B, Loessner M, Wehland J, Jansch L. J Bacteriol. 2007;189(2):313-24.Thedieck K, Hain T, Mohamed W, Tindall BJ, Nimtz M, Chakraborty T, Wehland J, Jansch L. Mol Microbiol. 2006;62(5):1325-39.Wissing J, Jänsch L, Nimtz M, Dieterich G, Hornberger R, Kéri G, Wehland J, Daub H. Mol Cell Proteomics. 2007;6(3):537-47.

First name:Jürgen

Last name:Wehland


Address:Helmholtz Center forInfection Research (HZI)Braunschweig



Department and function: Head, Molecular Immunology, HZI

Education:1969-1978 Biology at the Free University of Berlin,

Special Studies: Molecular Biology and Genetics1974-1978 PhD Student at the Basel Institute for Immunology,

Basel, Switzerland

Positions:1978-1980 Research Associate at the Salk Institute for Biological

Studies, Department of Developmental Biology, San Diego,USA.

1980-1983: Scientific Assistant at the Friedrich-Miescher-Laboratorium of the Max-Planck-Gesellschaft, Tübingen, Germany.

1983-1989: Member at the Basel Institute for Immunology, Basel, Switzerland.

1989-1990: Visiting Professor at the Institute for Immunology and Rheumatology, University of Oslo, Oslo, Norway.

1990-present: Group leader at the HZI (Helmholtz Center for InfectionResearch), Braunschweig, Germany.

Major research interests:Interaction of bacteria with the immune system.B cell development.

Selected PublicationsBruder D,et al. Int Immunol. 2006;18(1):89-100.Loessner H, et al. FEMS Microbiol Lett. 2006;265(1):81-8.Jablonska J, et al. Infect Immun. 2007;75(1):462-70.Becker C, et al.. J Mol Med. 2007;85(1):63-73.Loessner H, et al. Cell Microbiol. 2007;9(6):1529-37.Gekara NO, et al. Cell Microbiol. 2007; 9(8):2008-21.Stoermann B, et al. Eur J Immunol. 2007;37(6):1613-20.Loessner H, et al. Int J Med Microbiol. 2008;298(1-2):21-6. Gekara NO, et al. Cell Microbiol. 2008;10(1):225-36. Gekara NO, et al. Infect Immun. 2008;76(2):857-62. Westphal K, et al. Cancer Res. 2008; 68(8):2952-60.Grenningloh R, et al. Scand J Immunol. 2008 Jun;67(6):594-602. Lienenklaus S, et al. J Interferon Cytokine Res. 2008 Nov;28(11):653-60.Gekara NO, et al. J Infect Dis. 2009; 199(1):124-33.Roy B, et al. Mol Immunol. 2009 Feb 9. [Epub ahead of print]

First name:Siegfried

Last name:Weiss

Acad. Title:Dr. rer.nat.

Address:AG MolekulareImmunologie,Mascheroder Weg 1a,38124 Braunschweig

Phone and e-mail:++49-0531-6181-230, [email protected]

Further information:http://www.helmholtz-hzi.de/de/forschergruppen/molekulare_biotechnologie/molekulare_immunologie/team/personal/infos/siegfried_weiss/

Department and function:Hematology, Hemostasis and OncologyScientist (bone marrow transplantation; Experimental Hematology)

Education:1987: MD Medical Faculty, University of Vienna, Austria1997: Habilitation in Experimental Hematology, Ludwig-

Maximillians-Universität / Munich2005: APL-Professor/ Experimental Hematology

Positions:1989-1992: Visiting fellow at the National Institutes of Health, NCI, Laboratory of Genetics1992-1993: Visiting associate (NIH/NCI/LG)1993-1998: Junior group leader GSF / Hämatologikum / Munich1998-1999: Invited scientist NIH/ National Heart/Lung/Blood

Institute1999-2002: Scientific and clinical staff fellow MHH/ Hematology2002-2003: Chief medical officer mosaiques diagnostics GmbH2003- recent: Scientific group leader MHH/ Hematology

Major research interests:Gene therapy of Graft versus Host diseaseStem Cell Transplantation: experimental and clinical application

Antigen-specific T-cells : therapeutic and researchProteomics in clinical research and diagnosis

Selected Publications:Kaiser T., Kamal H., Rank A., Kolb H.J., Holler E., Ganser A., HertensteinB., Mischak H., Weissinger E.M. Blood 2004; 104: 340-349Weissinger, E.M., Mischak, H. Transplant Med.2004; 16:1-5Weissinger EM, Oettrich K, Evans C, Genieser HG, Schwede F, Dangers M, Dammann E, Kolb HJ, Mischak H, Ganser A, Kolch W. Br J Cancer. 2004;91(1):186-92.Weissinger EM, Nguyen-Khoa T, Fumeron C, Saltiel C, Walden M, Kaiser T, Mischak H, Drueke TB, Lacour B, Massy ZA. Proteomics. 2006;6(3):993-1000.Weissinger EM, Mischak H, Ganser A, Hertenstein B. Ann Hematol. 2006;85(4):205-11Ganser A, Morgan MA, Weissinger EM. Proc Natl Acad Sci U S A. 2007; 104(4):1109-10.Weissinger EM, Schiffer E, Hertenstein B, Ferrara JL, Holler E, Stadler M, et al. Blood. 2007 15;109(12):5511-9.Weissinger EM, Mischak H. Methods Mol Med. 2007;134:217-28.Weissinger EM, Zürbig P, Ganser A. Methods Mol Biol. 2009;506:437-52.

First name:Eva

Last name:Mischak-Weissinger

Acad. Title:Prof. Dr.med univ.




Department and function:Pediatric Hematology/Oncology

Education:1969-1973 University Tübingen, Medicine1973-1975 Freie Universität Berlin1975 Dr. med.1976 Approbation1984 Board certified Pediatrician

Positions:1985-1987 Assist. Professor, Head Laboratory of

Cytokine Biology, Memorial Sloan KetteringCenter, New York

1987-1993 Professor for Pediatrics, MHH1993-1997 Professor for Specific Pediatric Hematology

and Oncology, MHHSince 1997 Dept. of Pediatric Hematology/ Oncology, MHH

Major research interests:Cytokines, Hematopoietic stem cells, Bone marrow failuresyndromes, Leukemias

Selected Publications:Lauten M, et al. Haematologica. 2003; 88(11):1253-8.Zeidler C, et al. Rev Clin Exp Hematol. 2003; 7(1):72-83.Beger C, et al. Clin Cancer Res. 2004; 10(11):3780-7.Meissner B, et al. Leukemia. 2004; 18(11):1920-3.Kracht T, et al. Haematologica. 2004; 89(12):1492-7Cario G, et al.. Blood. 2005; 105(2):821-6Cloppenborg T, et al. Leukemia. 2005; 19(1):44-8Stanulla M, et al. Blood. 2005;105(2):906-7Cario G, et al. Br J Haematol. 2005; 129(2):275-8.Wang Z, et al. Ann N Y Acad Sci. 2005; 1044:29-40.Kardinal C, et al. Blood. 2006 Feb 1;107(3):1133-40.Germeshausen M, et al. Hum Mutat. 2006; 27(3):296.Skokowa J, et al. Nat Med. 2006;12(10):1191-7.Germeshausen M, Ballmaier M, Welte K. Blood. 2007;109(1):93-9.Klein C, et al. Nat Genet. 2007;39(1):86-92.Grigull L, et al. Pediatr Transplant. 2007;11(3):261-6.Meissner B, et al. Bone Marrow Transplant. 2007;40(10):945-9. Maecker B, et al. Bone Marrow Transplant. 2008;41(9):833-5.Zeidler C, et al. Br J Haematol. 2009;144(4):459-67. Skokowa J, et al. Nat Med. 2009 Feb;15(2):151-8.

First name:Karl

Last name:Welte


Address:OE 6780Hannover MedicalSchool


Further information:http://www99.mh-hannover.de/kliniken/paed_haemonko/

Department and function:Professor, Dermatology

Education:Medical Doctor, Professor of Medicine

Positions:1985-1989 Post Doc in the Dept´s of Immunology in Hannover and in Goettingen1989-1994 Clinicail Education in the the Field of Dermatology in Hannoversince 1994: Registrar („Oberarzt“) in the Dept of Dermatology

Major research interests:Dermatoimmunology:Specifity and functions of skin infiltrating T-cells in eczemaRegulation of cytokine pattern in human T-cells and antigen-presentingcellsExpression and function of anaphylatoxin receptors

Selected Publications:Gutzmer R, Kother B, Zwirner J, Dijkstra D, Purwar R, Wittmann M, Werfel T. J Invest Dermatol. 2006;126(11):2422-9.Purwar R, Wittmann M, Zwirner J, Oppermann M, Kracht M, Dittrich-Breiholz O, Gutzmer R, Werfel T. J Immunol. 2006;177(7):4444-50.Turjanmaa K, Darsow U, Niggemann B, Rance F, Vanto T, Werfel T. Allergy. 2006; 61(12):1377-84.Langer K, Breuer K, Kapp A, Werfel T. Exp Dermatol. 2007;16(2):124-9.Purwar R, Werfel T, Wittmann M. J Invest Dermatol. 2007;127(5):1271-4.Dijkstra D, Leurs R, Chazot P, Shenton FC, Stark H, Werfel T, Gutzmer R. J AllergyClin Immunol. 2007;120(2):300-7.Niebuhr M, Elsner J, Kapp A, Werfel T. Eur J Dermatol. 2007;17(4):340-1.Werfel T, Ballmer-Weber B, Eigenmann PA, Niggemann B, Rancé F, Turjanmaa K, Worm M. Allergy. 2007l;62(7):723-8.Purwar R, Kraus M, Werfel T, Wittmann M. J Invest Dermatol. 2008;128(1):59-66. Dijkstra D, Stark H, Chazot PL, Shenton FC, Leurs R, Werfel T, Gutzmer R. J Invest Dermatol. 2008;128(7):1696-703. Niebuhr M, Langnickel J, Draing C, Renz H, Kapp A, Werfel T. Allergy. 2008; 63(6):728-34.Niebuhr M, Mai U, Kapp A, Werfel T. Exp Dermatol. 2008;17(11):953-7. Purwar R, Langer K, Werfel T. Exp Dermatol. 2009 Jan;18(1):30-4.Raap U, Wichmann K, Bruder M, Ständer S, Wedi B, Kapp A, Werfel T. J AllergyClin Immunol. 2008;122(2):421-3. Niebuhr M, Mühlradt PF, Wittmann M, Kapp A, Werfel T. Exp Dermatol. 2008 Dec;17(12):1052-6.Raap U, Schmid-Ott G, Bruder M, Wichmann K, Kapp A, Werfel T. J Allergy ClinImmunol. 2008;122(6):1227-9. Schmid-Ott G, Jaeger B, Boehm T, Langer K, Stephan M, Raap U, Werfel T. Br J Dermatol. 2009 Jan 28. [Epub ahead of print]

First name:Werfel

Last name:Thomas

Acad. Title:Prof Dr. med.

Address:Dept DermatologyHannover Medical SchoolRicklinger Str. 530449 Hannover

Phone and e-mail:[email protected]@gmx.de

Further information:http://www.hautklinik-linden.de/

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