Gold Collection

Hallmark findings

•Autosplenectomy

– Sickle cell anemia: switch a glu val in chain

– Low O2 increased sickling– Aplastic crisis w/ B19 (Parvovirus

ssDNA) infection– Salmonella osteomyelitis– Vaso-occlusive painful crisises– Hydroxyurea as Txt (increased HbF)

& Bone marrow transplant

•Brushfield Spots

•Down’s

•Call-Exner Bodies

– Granulosa cell tumor: associated w/ endometrial hyperplasia & carcinoma– Granuloma-Theca cell

tumor

•Charcot Triad

•Multiple sclerosis = nystagmus, intention

tremor, scanning speech

•Cold Agglutinins

–Mycoplasma pneumoniae– Infectious

mononucleosis

•Cotton Wool Spots

– HTN– Aka, cytoid bodies seen w/ SLE (yellowish cotton

wool fundal lesions)

•Curschmann’s Spirals

•Bronchial asthma

•Donovan Bodies

–Granuloma inguinale (STD)

•Glitter Cells

–Acute Pyelonephritis

•Michealis-Gutmann Bodies

–Malakoplakia lesion on bladder due to macros &

calcospherites (M-G Bodies): usually due to

E. Coli

•Non-pitting Edema

–Myxedema–Anthrax Toxin

•Owls Eye Cells

– CMV– Reed Sternburg Cells

(Hodkins Lymphoma)– Aschoff cells seen w/

Rheumatic Fever

•Pautrier’s Microabscesses

–Mycosis fungoides (cutaneous T-cell

lymphoma), Sezary

•Psammoma Bodies

– Papillary adenocarcinoma of the thyroid

– Serous papillary cystadenocarcinoma of the ovary

– Meningioma– Mesothelioma

•Rash on Palms & Soles

– 2°Syphilis– RMSF

–Coxsackie virus infection: Hand-Foot-Mouth Disease

•Reinke Crystals

–Leydig cell tumor

•S3 Heart Sound

–LR Shunt (VSD, PDA, ASD)

–Mitral Regurg–LV Failure

•S4 Heart Sound

–Pulmonary Stenosis– Pulmonary HTN

•Schwartzman Reaction

•Neisseria meningitidis impressive rash with

bugs

•Smith Antigen

– SLE (also anti-dsDNA)– Malar Rash, Wire loop kidney

lesions, Joint pain, False (+) syphilis test (VDRL)

– 90% 14-45 yo females– also seen w/ use of INH;

Procainamide; Hydralazine = SLE-like syndrome

•Thyroidization of Kidney

•Chronic pyelonephritis

•Warthin-Finkeldey Giant Cells

–Measles

•Whipple’s Triad

–CNS dysfunction – Hypoglycemic

episodes - glu injection reverses CNS Sympt’s

•“Ground Glass” on chest x-ray (Hyaline)

–Due to Pneumocystis carinii

– Seen w/ Atelectasia

•Honey Combing of the lung

–Seen w/ Asbestosis (a restrictive lung

disease)

•PAS(+) Dutcher Bodies

•Waldenstrom’s Macroglobulinemia =

increased IgM = Hyperviscosity

•“Ground Glass” in Abdomen(Hyaline)

•Seen in the hepatocytes of healthy carriers of HBsAg in

liver biopsies

•Ground Glass Appearance (Hyaline)

– Seen w/ Progressive Multifocal

Leukoencephalopathy oligodendrocytes

– Nuclei seen in Papillary CA of the thyroid (malignant)

•Devic’s Syndrome

–“Neuromyelitis Optica”– A variant of multiple

sclerosis: rapid demyelination of the optic nerve & spinal cord w/ paraplegia

•c-erb B2 –

•Breast Cancer association

•Foster-Kennedy Syndrome

–A tumor causing blindness & loss of

smell w/ papilloedema

•Red Nucleus Destruction

•Intention tremors of the arm

•Ventral Spinocerebellar tr.

•Unconscious proprioception of lower extremities

•Dorsal Spinocerebellar tr.

•Unconscious prorpioception & fine

motor movements

•Cuneocerebellar tr.

•Unconscious proprioception & fine motor movements of

upper extremities

•Ventral Spinothalamic tr.

•Light touch perception

•LMN Lesion

–Werndig Hoffman (progressive infantile

muscular atrophy)– Poliomyelitis

•Sensory Pathway Lesion

– Subacute Combined Degeneration =

Friedrich’s Ataxia = B12 deficiency

– Tabes Dorsalis (Neurosyphilis)

•Suprachiasmatic Nucleus

•Controls circadian rhythm

•Ventromedial Nucleus

•Satiety center. Savage behavior & obesity

when lesioned

•Lateral Nucleus

•Induces eating. Starvation when

lesioned

•Arcuate Nucleus

•Releases PIF (dopaminergic

neurons)

•Acanthocytes

•RBSc w/ spiny projections. Seen in

Abetalipoproteinemia.