Go Geous - beneficial drink that will definitely

awaken even the most weakest of cells.

This exquisite product brings to you the secrets

of the future so advanced that its formula cannot

be compared to any other existing health

supplement in the market.

Highly efficacious and balanced formulation consist of :

PhytoCellTec™ Malus Domestica (Apple Stem Cells),

Rousselot Fish Collagen,

Acai Berry Extract,

Pine Bark Extract,

Grape Seed Extract,

L-Arginine and Mixed Berries.

Uttwiler Spätlauber (Malus Domestica)- an Apple with an Excellent Storage Ability

• Storage ability of apples was an

important factor to guarantee fresh

fruits over winter in the 18th

century

• Modern apple cultivars are selected

for a sweet flavour and therefore the

Uttwiler Spätlauber disappeared

• Today the Uttwiler Spätlauber apple

is an endangered apple variety with

only a few trees left in the world

The Secret of Storage Ability

• Longevity of cells

• High acid and tannin concentrations

• Undiscovered metabolites?

Young and Old

Plant Cell Culture Technology (PCT)

• PCT makes it possible to cultivate cells

of endangered and rare species

• The technology is based on

dedifferentiated plant cells

• These cells are plant stem cells and can

be cultivated in liquid systems

What are Stem Cells?

• Stem cells have two properties:

Self-renewal - the ability to go through

numerous cycles of cell division in an

undifferentiated state

Differentiation - the capacity to

differentiate into other cell types

• Toti-, pluri-, multi-, unipotent stem cells

Human: Embryonic Stem Cells (Pluripotent)

• Cells derived from the inner cell

mass of an early stage embryo

• Blastocyst, 4-5 days post

fertilization, 50-150 cells

• Pluripotent: Differentiate into one of

the more than 220 different cell

types of an adult body

• The use of embryonic stem cells in

medicine is discussed

controversially

Human: Adult Stem Cells (Multipotent)

• Undifferentiated cells among

differentiated cells in a tissue or

organ

• Generate all the cell types of the

organ from which they originate —

potentially regenerating the entire

organ from a few cells

• Primary roles: Replenish dying cells

and regenerate damaged tissues

Plant Stem Cells

Formation of Callus Tissue

• If a plant is wounded, a callus tissue is

formed (wound healing tissue)

• In the callus tissue the normal

differentiated cells go back into a

dedifferentiated form and become stem

cells (not possible in humans)

• Mechanism is controlled by different

plant hormones (auxins)

PhytoCellTecTM by Mibelle Biochemistry

• PhytoCellTecTM utilizes this unique totipotency of plant cells

• Only a small quantity of plant material of endangered species is

needed

• Induction of callus tissue by cutting plant parts

• Isolation of stem cells and cultivation on agar plates

From Callus to Plants

PhytoCellTecTM

• Complete dedifferentiation of the cells into a homogenous culture (4 -12

months)

• Transformation of the cells into liquid suspension

(1 - 6 months)

• Find optimal conditions for cell cultivation

(1 - 6 months)

Stem Cells and Aging

• Stem cells are responsible for the rejuvenation

• Stem cells are sensitive to environmental threats

• Chronological aging leads to the depletion of the number and activity of

stem cells

Protection of stem cells and activation of stem cell function is of great

importance in our body

Epigenetic Factors in Stem Cells

• Normal differentiated cells express only a limited amount of genes

(fibroblast: collagen; blood cells: hemoglobin)

• Stem cells have the possibility to express the whole DNA

• The epigenetic profile regulates the gene expression in stem cells

Activity of PCT Malus Domestica

1. Use of plant stem cells to protect stem cells

The components of Malus domestica stem cells are rich in epigenetic

factors relevant to protect and maintain the function of skin stem

cells.

2. Use of plant metabolites to delay senescence

The active ingredients of Malus domestica var. Uttwiler Spätlauber

cells contain metabolites which insure longevity of cells.

Study Results

Increase in Cell Number (Human Umbilical Cord Stem Cells)

0.1%0.01%Control0.00E+00

2.00E+04

4.00E+04

6.00E+04

8.00E+04

1.00E+05

1.20E+05

1.40E+05

Ce

ll n

um

be

r

Malus Domestica stem cell extract

Protection Against UV

(Umbilical Cord Stem Cells)

0.01%Control 0.1%

-50

-40

-30

-20

-10

0

Decr

ease

of

the liv

ing

cell

num

ber

in %

Malus Domest ica stem cell extract

Growth of Hair Follicle

Hair follicles From human skin fragments

(from micro dissection)

Test substance PhytoCellTecTM Malus Domestica 0.2%

Design Length of hair follicle increases until day 14

→ after day 14 induction of senescence

→ length of hair follicle decreases

Day 0 Day 4 Day 7

Length of Hair Follicle

-70

-60

-50

-40

-30

-20

-10

0

10

20

Day 16 Day 18 Day 20

Chang

e in

leng

th c

om

pare

d to

day

14 in

%

Control 0.2% Malus Domestica stem cell extract

Senescence of hair

(stem cells) can be delayed

PhytoCellTecTM Malus DomesticaEffect on Gene Expression in Senescent

Dermal Fibroblasts

Cell line Normal Human Dermal Fibroblasts

Design H2O2 induced senescence (2h)

followed by a treatment with

2% PhytoCellTecTM Malus

Domestica or not (144 h)

Parameters Gene profile (microarray)

PhytoCellTecTM Malus Domestica

Gene Profile (Microarray)

↓ Gen, that is down-regulated by senescence induction (see control)

↑ Gen, that is up-regulated or normalized in senescent cells by PhytoCellTec Malus Domestica

Gen After H2O2

Control

After H2O2

+ 2% Malus Domestica

stem cell extract

cyclin B1: induces proliferation 73 ↓ 130 ↑

cyclin E1: tumor inducer 78 ↓ 135 ↑

p53: tumor suppressor gene 63 ↓ 137 ↑

insulin-like growth factor II: cell proliferation enhancer 71 ↓ 117 ↑

heme oxigenase 1: antioxidans enzyme 89 ↓ 211 ↑

Summary

Product from rare Swiss Malus domestica var. Uttwiler Spätlauber

PhytoCellTecTM to produce stem cells from this apple

Product activity

1. Activation and protection of stem cells

2. Delay of senescence

Results show

• Protection of stem cells against UV-radiation

• Increase of activity of stem cells

• Decrease of senescence markers in fibroblasts

• Increase of life span of hair follicles

Claims

• Delays senescence of essential cells

• Protects longevity of stem cells

• Protection of stem cells

• Rejuvenation of cells

• Maintains the power of regeneration

• Combats chronological aging

Properties of PhytoCellTecTM

• PhytoCellTecTM is a preparation of plant stem cells

• PhytoCellTecTM is produced in Switzerland by a

novel plant cell culture technology

• PhytoCellTecTM contains plant stem cells to protect

and maintain stem cells

• The protection of stem cells is a breakthrough

approach in anti-aging

• Studies showed that PhytoCellTecTM protects human

stem cells and rejuvenates them

• PhytoCellTecTM delays chronological aging

PhytoCellTec™ Malus Demestica -

Benefits

• PhytoCellTecTM plant stem cells are a

breakthrough in anti-aging therapy

• Stem cell treatment is a revolutionary new

approach in healthcare industry

• Plant stem cells are extremely efficient but

also safe to use

• PhytoCellTecTM is based on real plant

stem cells to trigger the rejuvenation of the

body

• PhytoCellTecTM delays the natural aging

process by maintaining the activity of stem

cells

According to the US

edition of Vogue, the First

Lady buys a £215 serum

which uses an extract

from stem cells of the

Uttwiller Spattauber

apple

Rousselot™ Fish Hydrolyzed Collagen

Rousselot™ Hydrolyzed Collagen are natural proteins,

derived from the collagen found in fish skins and bones.

Some definitions of Collagen

Merriam Webster Dictionary

“…an insoluble fibrous protein

that occurs in vertebrates as the

chief constituent of connective

tissue fibrils and in bones…

Chemistry and Biology of proteins-

F.Haurowitz

Academic Press, Inc. – New York,1950

“…a structural protein of connective tissues

and composes the larger part of the

tendons, ligaments…(and)… a portion of

the bones, cartilage and skins..”

Rousselot™ Fish Hydrolyzed Collagen

Rousselot™ Hydrolyzed Collagen is 92% pure protein made of all

essential amino-acids, particularly rich in alanine, arginine, glycine,

glutamic acid and proline.

Alanine*: Involved in the supply of energy to muscle tissues, brain and central

nervous system, alanine plays a role in the metabolism of sugars and organic

acids. It strengthens the immune system through its effect on antibody

production.

Arginine*: Useful for immune system stimulation, arginine is involved in the

wound healing process and the secretion of hormones.

Rousselot™ Fish Hydrolyzed Collagen

Glutamic Acid*: An important excitatory neurotransmitter, glutamic acid helps

speed the healing of ulcers and gives relief from fatigue.

Glycine*: Beside its nutrient role for a strong immune system, glycine triggers

the release of the oxygen required by the cell-making process. It is also a fast

inhibitory neurotransmitter.

Proline*: Important for joints and tendons adequate functioning, proline

participates in heart muscle strengthening.

*Non-essential amino-acid.

Rousselot™ Fish Hydrolyzed Collagen – Clinical

Studies

Comprehensive clinical studies carried out in Japan and France confirm the effect of

taking Rousselot™ Hydrolyzed Collagen on skin health.

Background :

Fine lines, wrinkles, and loss of elasticity are symptoms commonly associated with

aging skin. Accumulated environmental

exposure and a natural decrease in cell renewal contribute to other signs less often

associated with aging: dull, rough, or dry skin.

The latest investigative studies using state-of-the-art technology have challenged the effect of

Rousselot™ Hydrolyzed Collagen. Two clinical studies were carried out by global independent

skin health research organizations having a well

proven approach for verifying product performance claims. Mechanical measurements and

volunteers were assessed by certified skin experts.

Rousselot™ Fish Hydrolyzed Collagen – Clinical

Studies

Conclusion

These two clinical studies demonstrated the benefits of Rousselot™ on skin health.

Taken daily, up to 12 weeks, the results verify that regular intake of Rousslet™ Hydrolyzed

Collagen improves the basic skin condition and structure.

Rousslet™ Hydrolyzed Collagen has clinically shown to:

Improve skin moisture level

Improve skin smoothness by reducing the number of micro-relief furrows

Prevent the formation of deep-wrinkles

Improve skin suppleness

Rousslet™ Hydrolyzed Collagen, a completely characterized and scientifically

objectivized natural bioactive ingredient that improves epidermis moisture content and

prevents skin aging.

Acai Berry

The Acai (ah-sigh-ee) Berry has been around for thousands of years

and not until the 1990's was it introduced to the western world. The

acai berry was found to possess tremendous health properties. The

acai berry was first used by the tribes of the Amazon jungle as a

cure for various ailments.

The acai berry was discovered to have natural antioxidant properties,

as well as being a natural cholesterol controller. When eaten it helps

reduce the bad cholesterol in our blood and increases the good

cholesterol. The tribes of the Amazon knew of these properties and

found out that it helped build the immune system, fight infection,

protect the heart, and control prostate enlargement (nature's viagra).

It was a great energy food for the tribes-people.

Acai Berry - Benefits

• A remarkable concentration of antioxidants that help combat premature

aging, with 10 times more antioxidants than red grapes and 10 to 30 times

the anthocyanins of red wine.

• An almost perfect essential amino acid complex in conjunction with valuable

trace minerals, vital to proper muscle contraction and regeneration.

• The fatty acid content in açaí resembles that of olive oil, and is rich in

monounsaturated oleic acid. Oleic acid is important for a number of reasons:

• It helps omega-3 fish oils penetrate the cell membrane; together they help make

cell membranes more supple. By keeping the cell membrane supple, all

hormones, neurotransmitter and insulin receptors function more efficiently. This is

particularly important because high insulin levels create an inflammatory state,

and we know, inflammation causes aging.

• Acai Berry does contain Omega-3 fatty acids, Omega-6 and Omega-9. Each

of these can lower the so-called bad cholesterol, or LDL, and each can

maintain our HDL, or good cholesterol.

Acai Berry – Other Benefits

Healthier Skin- The berry contains many unique properties that work to make your

skin look and feel younger.

Weight loss - Increases the metabolism in the body, which helps in reducing

the unwanted fats from the body.

Increases Energy- Our active lifestyles leave us drained of energy. Many of us

don’t get enough sleep, and we walk around all day like zombies. This creates

serious long-term medical conditions. Thankfully, Acai Berry helps improve your

overall energy. You can rest better, and wake up more refreshed in the morning.

Improves Blood Flow- Poor circulation can lead to numerous medical

conditions (clotting, balding, and heart issues.) Acai Berry supplements work to

improve your blood flow, thus staving off many serious ailments. Improved

circulation makes you feel better and live longer.

Acai Berry – Other Benefits

Stronger Heart- Heart disease is one of the leading causes of death in America. From

lack of exercise to poor dietary habits, our hearts endure a lot of stress. Acai Berry

supplements give your heart the nutrients it needs to work properly.

Better Concentration- Another of the seemingly endless benefits of Acai Berry is

the improved mental clarity it produces. In a way, this goes back to the circulation

benefits. With better blood flow, your brain is able to operate more efficiently.

Reduced Cholesterol- When you think of lowering your cholesterol, you probably

recall images of eating healthy foods that taste terrible. Acai Berry supplements

save you the trouble of eating tasteless oats. This berry will lower your cholesterol

significantly over time.

Detoxifies Body- Acai Berry contains several antioxidants that work to eliminate

harmful substances from your body. Throughout our life, our body absorbs many

damaging substances. Acai Berry works to eradicate them, and to make your

immune system stronger than ever before.

Enhances Sexual Performance- Known as Viagra of Amazon

Pine Bark Extract

Pine bark extract is made from the bark of a European

coastal pine tree called the Landes or maritime pine,

whose scientific name is Pinus maritima.

Researchers have termed the group of

antioxidants found in pine bark extract oligomeric

proanthocyanidins, or OPCs for short. OPCs (also

referred to as PCOs) are some of the most

powerful antioxidants available.

Pine Bark Extract

Antioxidants play a key role of repairing and protecting cells in the body. They

help protect against free radicals, which are damaging byproducts of metabolism

and exposure to environmental pollutants. Free radical damage is believed to

contribute to aging, as well as too severe conditions including heart disease and

cancer.

Much research has been conducted on OPCs and on pine bark extract. In France,

pine bark extract and OPCs have been rigorously tested for safety and

effectiveness, and pine bark extract is a registered drug.

Pine Bark Extract

Pine bark extract has been shown to contain a powerful antioxidant that helps

protect cells from free radical damage and increases the effectiveness of vitamin C.

Pine bark extract has been shown to help lower cholesterol, and to decrease the risk

and severity of atherosclerosis, or damage to the arteries. It has been demonstrated

to help strengthen and repair tissues made of collagen, a protein that builds blood

vessels, skin, and connective tissue.

The OPCs in pine bark extract have also been shown to help reduce swelling and

inflammation in the body.

Pine Bark Extract - Benefits

Pine bark extract is used to reduce the risk and severity of heart

disease, strokes, high cholesterol, and circulation problems.

It is used in the nutritional treatment of varicose veins and oedema,

which is swelling in the body due to fluid retention and leakage of

blood vessels.

Arthritis and inflammation have also been improved in studies using

pine bark extract, as well as the uncomfortable symptoms of PMS and

menopause.

Pine Bark Extract - Benefits

The OPCs in pine bark extract are recommended for various eye

conditions that are caused by blood vessel damage, such as diabetic

retinopathy and macular degeneration.

Pine bark extract is recommended to improve the health and

smoothness of the skin, including damage caused by overexposure

to sunlight.

Pine bark extract is a supplement used for anti-aging and preventive

care as well.

Grape Seed Extract

Grape Seed Extract (GSE) is a natural plant

constituent (bioflavonoid) which strengthens and

protects living tissue. The Oligomeric

Proanthocyanidins (OPC) components in GSE are

50 times stronger than Vitamin E and 20 times

stronger than Vitamin C.

Grape Seed Extract is an antiallergenic,

antihistamine, anti-inflammatory, and antioxidant.

It strengthens blood vessels, improves skin, and

aids in circulation.

Grape Seed Extract is prescribed by doctors in several

European countries for the prevention and treatment of a

variety of health problems including cardiovascular

disease, varicose veins, water retention, collagen damage

and arthritis. Because it is used pharmaceutically, it has

undergone a tremendous amount of testing.

Grape Seed Extract

Grape Seed Extract is an extraordinarily safe and effective

nutritional supplement.

Grape Seed Extract provides cardiovascular protection by

preventing oxidation of lipoproteins (LDL), making them less

likely to stick to blood-vessel walls.

It also makes the linings of the arteries more resistant to damage

and helps control excessive clotting.

GSE strengthens the capillaries ensuring a good supply of oxygen

and nutrients to the brain and throughout the body. It also affects

enzymes that influence blood-fluid balances and therefore may be

helpful in lowering blood pressure.

Grape Seed Extract

Grape Seed Extract - Benefits

Below are some health benefits of grape seed extract:

* Grape seed extract is one of the most powerful antioxidants that fights free

radicals

* Grape seed extract is 20 times more potent than Vitamin C and 50 times stronger than Vitamin

E

* Grape seed extract helps improve cardiovascular health

* It also helps promote brain, skin and eye health

* Grape seed extract is also anti-bacterial, anti-viral, and anti-inflammatory

* Grape seed extract is one of the few antioxidants that can penetrate the blood

brain barrier to help protect the brain and nerve tissue

* Some studies have also shown grape seed extract to prevent the formation of

plaque in the arteries

* It can also improve mental alertness and help prevent senility

Recently, researchers discovered that Grape Seed Extract can help to stimulate healthy hair growth by defeating the hormone dihydrotestosterone (DHT) that stops the hair follicle growth cycle.

Grape Seed Extract - Benefits

L - Arginine

L-Arginine Could Be A Magic Bullet In Anti-Aging Arsenal

Columbia University refers to L-arginine as the "magic bullet" for the

cardiovascular system

Properties of L-arginine were validated by the 1998 Nobel Prize in Medicine, and

since then have created a frenzy of interest in the Pharmaceutical and Nutraceutical

fields.

Medical researchers have gathered enough clinical evidence to bring L-arginine to

the forefront of modern medicine as an accepted treatment for a variety of human

ailments. The L-arginine phenomen is changing standard treatment methodologies in

heart disease, immune function, adiposity-generated diseases, genetic growth

deficiencies, high blood pressure, sexual disfunction, and human aging.

L – Arginine - Benefits

The efficacy of L-arginine as a therapeutic agent has been validated

by thousands of clinical studies.

The benefits and functions attributed to oral ingestion of L-arginine

include:

• Precursor for the synthesis of Nitric Oxide (NO)

• Stimulation of the release of the most important anti-aging

hormone in the body; growth hormone.

• Improves immune function

• Reduces risk of heart disease

• Natural Alternative to Viagra

• Increases muscle mass

• Reduces adipose tissue body fat

• Helps improve insulin sensitivity

• Helps decrease blood pressure

• Alleviates male infertility, improving sperm production and motility

L – Arginine - Benefits

L – Arginine - Obesity

Obesity is characterized by increased levels of insulin (high glycemic foods and

drinks) and by subnormal growth hormone (GH) release.

Insulin promotes fat and carbohydrate storage while GH stimulates lipolysis (fat-

burning). The insulin/growth hormone ratio is significantly higher in obese

humans than in lean humans.

The combination of high insulin and low GH exacerbates the obese condition. L-

arginine is the main oral agent responsible for restoration of GH in humans, and

administration of L-arginine taken at bedtime on an empty stomach 30 minutes

prior to Delta sleep reinstates normal GH levels.

Mixed Berries – Strawberry, Bilberry, Raspberry,

Elderberry, Blackcurrant, Red Beet

They’re loaded with fiber, which helps you feel full (and eat less).

A recent study even showed that one-half to one cup of mixed

berries a day improved cognition and motor performance in

animals.

Mixed Berries – Strawberry, Bilberry, Raspberry,

Elderberry, Blackcurrant, Red Beet

Top the charts in antioxidant power, protecting your body

against inflammation and free radicals, molecules that can

damage cells and organs.

Mixed Berries – Strawberry, Bilberry, Raspberry,

Elderberry, Blackcurrant, Red Beet

James Joseph, PhD, director of the Neuroscience Lab at the

United States Department of Agriculture Human Nutrition

Research Center on Aging at Tufts University, Boston, which

conducted the study, notes that we become more susceptible to

the damaging effects of free radicals and inflammation as we

age.

Berries help prevent those effects by turning off the

inflammation signals triggered by cytokines and COX-2s,

making them an ideal part of your diet