Filename:KUL1802_13793_GLUMA_Desensitizer_PowerGel_Scientifi c_Informa-tion_Effi cacy_Bologna_Scientifi c_Info GB 012018

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Date Kulzer fi nal release04-05-2018

Clinical study – University of Bologna, ItalyIn vitro and in vivo evaluation of the effectiveness of three dentine desensitizing treatment regimens

Several clinical trials have demonstrated GLUMA Desensitizer’s effective and long-lasting reduction of dentine hypersensitivity. The following study confirms as well the efficacy of GLUMA Desensitizer PowerGel in reducing dentine hypersensitivity.

GLUMA® Desensitizer PowerGel

Giving a hand to oral health.

Scientifi c Information

KUL1802_13793_GLUMA_Desensitizer_PowerGel_Scientific_Information_Efficacy_Bologna_Scientific_Info GB 012018.indd 1KUL1802_13793_GLUMA_Desensitizer_PowerGel_Scientific_Information_Efficacy_Bologna_Scientific_Info GB 012018.indd 1 05.04.18 11:0605.04.18 11:06

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ObjectiveTo evaluate the in vitro and in vivo effects of 3 different treatments on dentine permeability and reduction of dentine hyper-sensitivity.

Materials & MethodsThe desensitisation treatments were: GLUMA Desensitizer PowerGel, MS Coat One (Sun Medical) and dentine burnishing with fiber-resin burs. A split-chamber device was used to investigate the permeability of dentine slices cut from human molars in vitro. Fluid flow through dentine was recorded with a photochemical method after EDTA cleaning, albumin soaking and desensitisa-tion treatment (n = 10). 61 study participants with three severely hypersensitive teeth each were recruited. Sensitivity was determined with an air stimulus before, immediately after treatment, and after 6 months, using a verbal rating scale.

Results

52 out of 61 patients were available for the 6-month recall. All treatments reduced fluid flow through dentine (P > 0.05). All treatments reduced dentine hypersensitivity significantly. Statistical results revealed significant differences among the treatments (P = 0.03). Statistical analysis revealed that GLUMA Desensitizer PowerGel and the fiber-resin bur led to a superior hypersensitivity reduction than MS Coat One.

ConclusionBoth the topical desensitiser applications and the dentine burnishing treatment were effective in reducing dentine hyper-sensitivity for 6 months. GLUMA Desensitizer PowerGel and dentine burnishing with fiber-resin burs showed consistently high reduction in sensitivity. Whereas teeth treated with the oxalate containing MS Coat One regained some sensitivity over time.

CommentGLUMA Desensitizer PowerGel is very effective in reducing cervical dentine hypersensitivity.

SourceDondi Dall’Orologio et al.: In vitro and in vivo evaluation of the effectiveness of three dentine desensitizing treatment regimens. Am J Dent, 2014, 27:139-144.The study was abbreviated, summarised and commented and all diagrams and titles have been established by Kulzer.

Clinical study – University of Bologna, Italy In vitro and in vivo evaluation of the effectiveness of three dentine desensitizing treatment regimens

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GLUMA Desensitizer PowerGel leads to an effective reduction of dentine hypersensitivity directly after application and up to 6 months

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no discomfort (0) slight discomfort (1) severe discomfort during stimulation (2)

severe pain during and continuing stimulation (3)

After 6 monthsBaselinePre-operative

MS Coat One fiber-resin bur

GLUMA Desensitizer

PowerGel

MS Coat One fiber-resin bur

GLUMA Desensitizer

PowerGel

MS Coat One fiber-resin bur

GLUMA Desensitizer

PowerGel

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3 3 3

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