glucose-6-phosphate dehydrogenase (g6pd) …...distribution of g6pd, fava beans, and malaria ....
TRANSCRIPT
Glucose-6-Phosphate Dehydrogenase (G6PD)
Deficiency
Introduction
GENETICS
INHERITANCE RACE
INHERITANCE PD dehydrogenase gene is carried 6G
on the X chromosome
Females produce the same amount of G6PD enzyme as males
There are variant alleles of the G6PD gene
18.5 Size of gene (in kilobases)
DNA 13 Number of exons
12 Number of introns
2269
Size (in nucleotides) mRNA
515 Number of amino acids
Protein 59,265
Molecular weight (in Daltons)
2 or 4 Subunits per molecule of active enzyme
The G6PD enzyme catalyzes an oxidation/reduction reaction
CLINICAL ASPECTS
Definition Causes
Complications
Diagnosis Treatment
Medications that expose RBCs to higher than normal amounts of
Oxidative stress
Aspirin
Sulfonamides
Quinine Chloroquine
Primaquine