GLOBAL INJECTABLE DRUGDELIVERY TECHNOLOGYMARKET

Market Shares, Forecasts& Trends

2014 - 2020

mordorintelligence.com

Global Injectable Drug Delivery Technology Market | Sample 1 | Mordor Intelligence

TABLE OF CONTENTS

1. INTRODUCTION 1

1.1 Report Description 1

1.2 Research Methodology 2

1.3 Stakeholders 3

2. EXECUTIVE SUMMARY 4

2.1 Key Findings 4

2.2 Market Overview 5

3. MARKET OVERVIEW 6

3.1 Market Definition 6

3.1.1 Introduction 6

3.1.2 Modes of Injectable Drug Delivery systems 7

3.2 Market Drivers 8

3.2.1 Increasing prevalence of Chronic Diseases 8

3.2.2 Increased Demand 9

3.2.3 Technological Advances 10

3.3 Market Limitations 11

3.3.1 Injuries and Infections 11

3.3.2 Recent Advancements 12

3.3.3 Regulatory Framework 13

3.4 Market Challenges 14

3.4.1 Sustainability 14

3.5 Market Opportunities 15

3.5.1 Emerging Countries 15

Global Injectable Drug Delivery Technology Market | Sample 1 | Mordor Intelligence

4. Global Injectables Drug Delivery Technology Market Segmentation 17

4.1 Types 17

4.2 Devices 20

4.3 Application 23

4.4 Geography 27

5. Global Injectables Drug Delivery Technology Device Market 32

5.1 Conventional Drug Delivery Devices 32

5.2 Self Injectable Devices 35

5.2.1 Prefilled Syringes 36

5.2.2 Injectable Pen 39

5.2.3 Auto Injectors 42

5.2.4 Needle free Injectors 45

5.2.5 Self flushing infusion bag 48

6. GLOBAL MARKETS: SEGMENTATION BY GEOGRAPHY 51

6.1 North America 51

6.1.1 US 52

6.1.2 Canada 54

6.2 Europe 56

6.2.1 UK 57

6.2.2 Germany 59

6.2.3 France 61

6.3 APAC 64

6.3.1 India 65

Global Injectable Drug Delivery Technology Market | Sample 1 | Mordor Intelligence

6.3.2 China 67

6.3.3 South Korea 69

6.3.4 Japan 71

6.4 Rest of the World 73

6.4.1 Brazil 74

6.4.2 Middle East 76

6.4.3 Australia 78

7. Competitive Landscape 79

7.1 Introduction 79

7.2 Mergers & Acquisitions 80

7.3 Expansions 84

7.4 New Product Launch 87

7.5 Collaborations 90

8. Top Company Profiles 94

8.1 Alkermes Inc. 95

8.2 Genentech Inc. 99

8.3 Bend Research 103

8.4 QLT Inc. 106

8.5 Endocyte 109

8.6 BIND Biosciences, Inc. 112

8.7 UCB Group (UCB) 115

8.8 Presage Bioscience 118

8.9 Polymer Factory 121

8.10 MicroCHIPS, Inc. 124

Global Injectable Drug Delivery Technology Market | Sample 1 | Mordor Intelligence

8.11 Pearl Therapeutics Inc. 127

8.12 Piedmont Pharmaceuticals 130

8.13 Zogenix, Inc. 133

8.14 Liquidia Technologies 136

8.15 Impax Laboratories Inc. 140

8.16 Boehringer Ingelheim 143

8.17 Crossject Medical Technology 146

8.18 Apogee Technology 149

8.19 Pulmatrix 152

8.20 Medicago 155

9. Appendix 159

9.1 Abbreviations 159

9.2 Sources 161

9.3 Bibliography 163

9.4 Disclaimer 165

Global Injectable Drug Delivery Technology Market | Sample 1 | Mordor Intelligence

1. INTRODUCTION

1.1 REPORT DESCRIPTION

Injectables allow the transport of drugs formulated in liquid form, directly in the body. Such drug delivery

technology is majorly segmented based on devices and formulations. Based on product, the injectable drug

delivery devices technologies market is further categorized into conventional injection devices, self-injection

devices, and others (micro needles, nano needles and blunt needle injections), while injectable drug delivery

formulation technologies market is categorized into conventional drug delivery formulations and novel drug

delivery formulations.

The Injectable Drug Delivery Market is estimated to be USD 34.3 billion for the year 2014 and is expected to grow

during the forecasted period by a CAGR of about 18.1% and is expected to reach 78.79 billion USD by the end of

the year 2019.

The Market is basically segmented into four categories namely on the basis of formulation, devices, application

and geographical basis. Based on formulation the market is segmented into categories which are Conventional

drug delivery and Novel Drug Delivery. On the basis of devices the market is segmented into categories which are

Conventional devices and self-injectable devices. On the basis of application the market can be segmented into

categories like Oncology, Diabetes, Hep C and others, etc. The market analysis is also provided for different

geographical areas which include North America, Europe, APAC and rest of the world.

The major factors which drive the market growth are technological advances and increasing demand for devices.

With the major limitations being injuries and infections due to Injectables and regulatory framework issues.

Global Injectable Drug Delivery Technology Market | Sample 1 | Mordor Intelligence

1.2 RESEARCH METHODOLOGY

1) Secondary Research: Information was collected from a number of public and paid data sources. Public

sources involved Government websites, publications from the testing programs of different countries,

company annual reports, white papers and research publications by recognized industry experts. Paid

data sources include authentic industry databases.

2) Primary Research: After collecting data from secondary sources, primary interviews were conducted with

stakeholders at different points of the value chain like manufacturers, distributors, ingredient suppliers,

companies producing enzymes and key opinion leaders of the industry. Primary research is used both to

validate the data points obtained from secondary research and to fill any gaps in data.

3) Market Analysis: The market analysis phase involves analyzing the collected data, market breakdowns

and forecasting. Macroeconomic indicators and bottom-up and top-down approaches are used to arrive

at a complete set of data points that give way to valuable qualitative and quantitative insights. Each data

point is verified by the process of data triangulation to validate the numbers and arrive at a close

estimate.

4) Expert Validation: The market analysis data is verified and validated by a number of experts, both in-

house and external.

5) Report Writing: After the data is curated through the process, our analysts begin to write the report.

Garnering insights from data and forecasts, insights are drawn to visualize the entire business

ecosystem in a single report.

Global Injectable Drug Delivery Technology Market | Sample 1 | Mordor Intelligence

3. MARKET OVERVIEW

3.2 MARKET DRIVERS

3.2.1 INCREASING PREVALENCE OF CHRONIC DISEASES

Due to the changing demographic conditions there is an increase in the global aging population. This has

increased the prevalence of chronic diseases like diabetes, rheumatism, or cancer which often needs parenteral

drug usage. Administering these parenteral drugs at medical center or clinics puts a great strain on the

healthcare systems budget and also on the patient’s quality of life. Prefilled syringes or auto injectors suitable for

home treatment are therefore becoming more and more significant.

3.2.2 INCREASED DEMAND AND COST

With close to 60% of the global population being 50 or above the demand for treatment for chronic diseases is on

the rise. With this rise the pressure on costs are also going up. The rising cost in the healthcare system is turning

to be a point of concern for healthcare providers as well as patients. These increasing costs are leading to the

scenario called ‘patient cliff’. This is leading to increased dependence on generic versions of essential drugs

which only cost half the innovators. In this case the prefilled syringes would be selected on the basis of cost with

cheaper version selling more, making cost effectiveness a necessity

3.2.3 TECHNOLOGICAL ADVANCES

The drug delivery design is now shifting to incorporate more ergonomic design features to simplify the

administration process for both patients and medical practitioners. In this context the vial and ampoule systems

are being increasingly replaced by prefilled syringes and autoinjectors, which guarantee precise dosage and

saves time as the medication need not be drawn into the syringe and there are no disposable needles to change.

Another factor driving innovation is the primary packaging section which is seeing tougher safety requirement to

prevent needle stick injuries, leading to the development of new primary packaging systems that are more

ergonomic in nature and easier to use, plus the fact that using autoinjectors allows the medication to be provided

at home for patients in need thus driving the overall costs down.

Global Injectable Drug Delivery Technology Market | Sample 1 | Mordor Intelligence

5. GLOBAL INJECTABLES DRUG DELIVERY TECHNOLOGY DEVICE MARKET

Geographically, North America is the leading market in terms of market share. Following North America is Europe.

Emerging markets like China and India will show significant growth in the future and the market is yet to be

penetrated.

Global IDDS Market 2014-2019 ($ Billion)

Region 2012 2013 2014 2019 CAGR

NA XX 8.71 XX XX XX

EU 11.08 XX XX XX XX

APAC XX XX XX 12.61 XX

ROW XX XX 3.77 XX XX

Total XX XX XX XX XXSource: Mordor Intelligence Analysis

Globally, developing markets hold the market share as high as 85% on the global arena. Below is the table for

market share on the basis of geography.

Source: Mordor Intelligence Analysis

Global IDDS Market Distribution 2013

NA

EU

APAC

ROW

DATA HIDDEN FROM VIEW

Global Injectable Drug Delivery Technology Market | Sample 1 | Mordor Intelligence

5.2 SELF INJECTABLE DEVICES

5.2.1 PREFILLED SYRINGES

It is estimated that nearly 48000 deaths occur on an yearly basis due to nosocomial infections and the additional

expenses incurred due to these nosocomial infections is nearly $8 billion. In light of these numbers it is not

surprising that the market for Prefilled syringes has witnesses a significant growth in the recent times. This can

be attributed to the immense advantage it possesses over the other forms of drug delivery. From an end user

point of view prefilled syringes offer ease of administration and compliance benefits; from a pharmacy

perspective prefilled syringes offer potential to avoid mixture related medical errors; from a manufacturer

perspective, increased competition for scarce economic resources within healthcare system to provide for the

additional requirements in the event that the product’s commercialization objectives are achieved. Although the

market is relatively new, it accounts for about 25% of the total injectable drug delivery market on a global scale.

Depending on the type of material used to manufacture the syringe barrel, prefilled syringes can be divided into

two categories namely glass prefilled syringes and plastic (polymer) prefilled syringes. It is expected that the use

of plastic prefilled syringes will increase significantly in the near future. Developed markets of US and Europe

account for more than 83% of the global prefilled syringes market in 2014.

Prefilled Syringes market is forecasted to grow significantly during the period of 2014-2019. The market is valued

at nearly $4.5 billion in 2014. It is expected to grow at a CAGR of 11.91%.

Global Injectable Drug Delivery Technology Market | Sample 1 | Mordor Intelligence

Source: Mordor Intelligence Analysis

0

1

2

3

4

5

6

7

8

9

2012 2013 2014 2015 2016 2017 2018 2019

$ Bi

llion

Growth of Prefilled Syringe Market (2012-2019)

DATA HIDDEN FROM VIEW

Global Injectable Drug Delivery Technology Market | Sample 1 | Mordor Intelligence

6. GLOBAL MARKETS: SEGMENTATION BY GEOGRAPHY

6.1 NORTH AMERICA

The North American injectable drug delivery technologies market was valued at $10.29 billion in 2014 and is

poised to grow at a CAGR of 20.37% from 2014 to 2019 to reach $26 billion by 2019.The US predominantly uses

MDV’s, but PFSs have gained market share throughout the past few year. Currently PFSs hold approximately 30%

of the market share for influenza vaccine. Preparation of injectable medications, the opportunity to extend

medication or vaccine supply due to the reduced overfills requirements (vs. vials) are the major driving factors for

the market in US region. Around a third of novel injectable drugs and vaccines launched in the US during recent

years have been in lyophilized format.

North American Market For IDDS 2014- 2019 ($billion)

Country 2012 2013 2014 2019 CAGR (%)

USA 4.43 5.23 6.17 14.30 18.31

Canada 2.58 3.05 3.60 9.62 21.72

Source: Mordor Intelligence Analysis

Global Injectable Drug Delivery Technology Market | Sample 1 | Mordor Intelligence

8. COMPANY PROFILES

8.16 BOEHRINGER INGELHEIM

Headquarters

Boehringer Ingelheim GMBH

Binger Strasse 173

55216 Ingelheim am Rhein

Phone +49 - 6132 - 77 0

Fax +49 - 6132 - 72 0

INTRODUCTION:

Boehringer Ingelheim founded in Ingelheim am Rhein in 1885 is one of the world’s top 20 pharmaceutical

companies. It is a group of companies dedicated to the research, developing, manufacturing and marketing novel

products of high therapeutic value for human and veterinary healthcare. As of 2013, it has 142 affiliated

companies worldwide and a workforce of about 47,492 employees.

FINANCIALS:

The company generated revenue of 14.065 billion Euros for the year 2013. This was a 4% decrease in global

revenue compared to the year 2012 when the revenue generated at that time was 14.691 Euro.

PRODUCTS:

Boehringer Ingelheim’s major business areas comprise of products in the field of Consumer healthcare,

prescription medicines, animal healthcare and Boehringer Ingelheim BioXcellence.

The Consumer healthcare sector of Boehringer Ingelheim generates 11% of the global revenue

generated. The consumer healthcare sectors constitute of nine major brands. These are Antistax,

Bisolvon, Buscopan, Dulcolax, Mucoangin, Mucosolvan, Pharmaton, Thomapyrin and Zantac.

Prescription Medicine accounts for about 77% of the total revenue generated by Boehringer Ingelheim.

The major products in this sectors are Spiriva, Trajenta, Viramune, Aptivus, Micardis, Afatinib, Metalyse,

Mirapex, Sifrol, Pradaxa, and Actilyse.

Global Injectable Drug Delivery Technology Market | Sample 1 | Mordor Intelligence

Animal Health business generated 8% of the total revenue generated. The major products in this sector

are Enterisol Iletis, Metacam and Ingelvac.

Boehringer Ingelheim BioXcellence is a world-leading biopharmaceutical contract manufacturer.

ANALYST VIEW

Boehringer Ingelheim’s business division BioXcellence is a leading biopharmaceutical contract manufacturer. It

offers its customers the drug product manufacturing chain comprising of filling, lyophilisation, packaging and

labeling. The company’s recent entry into China for the development of biopharmaceuticals in an agreement with

Zhangjiang Biotech & Pharmaceutical Base Development Company with an investment of about 65 million Euros

is a signal of intent from Boehringer Ingelheim to penetrate the untapped market of biopharmaceuticals in China.

It is observed that Boehringer is the first international company using cell culture technology in China to produce

biopharmaceuticals. Its recent collaboration with the Swedish pharmaceutical company Sobi in getting the

approval of FDA in the manufacture of Kineret has been big news in the pharmaceutical market. The acquisition

of Amgen’s Fremont by Boehringer Ingelheim has also been a sign of its strength of Boehringer Ingelheim on a

global scale. The technological expertise at Amgen will strengthen the manufacturing business of Boehringer

Ingelheim. It has also expanded its biopharmaceutical development and manufacturing capabilities at its cell

culture sites in Germany and Austria. The recent shift from the use of MDV drug delivery to the primary use of

PFS (prefilled syringes) has been a major technological change compared to other competitors where the use of

prefilled syringes is still in the starting stages. This has given Boehringer a head start in the drug delivery

technology market. PFS related costs are less and is simple. Boehringer is able to save a lot of capital due to this

transition. At this rate Boehringer is inclined to become the leading biopharmaceutical solution provider in the

emerging market sector. It has also started a novel project transfer program which enables fast track launch for

Global Injectable Drug Delivery Technology Market | Sample 1 | Mordor Intelligence

biopharmaceuticals. With its wide range of facilities in the development of drug delivery technologies, Boehringer

Ingelheim is a company with intent to become the top global organization in the field of biopharmaceuticals.

Global Injectable Drug Delivery Technology Market | Sample 1 | Mordor Intelligence

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