Global Academic Programs

Oliver Bogler, PhD

VP Global Academic Programs

Senior VP, Academic Affairs

Kian Ang, M.D., Ph.D.

• Professor, Radiation Oncology

• Vice President Global Academic Programs 2012/3

• expert clinician• highly accomplished

clinical and translational scientist

• a respected educator• trusted friend & valued

colleague

Mission and Objectives

• MD Anderson’s mission:– … to eliminate

cancer in Texas, the nation and the world …

– Global Academic Programs (GAP) supports the work of our faculty via the Sister Institution Network:

• 33 Sister Institutions in 24 countries incl. 5 consortia– list at www.mdanderson.org/gap

• the largest global network of cancer centers working collaboratively to accelerate the mission of Making Cancer History

– Network is a platform to support work in patient care, research, prevention and education

University Cancer Centers• China - Fudan University Cancer Hospital, Shanghai• China - Cancer Hospital and Institute, Chinese Academy of

Medical Sciences, Beijing• China - Sun Yat-Sen University Cancer Center, Guangzhou• China - Tianjin Medical University Cancer Institute and

Hospital, Tianjin• China - Chinese University of Hong Kong, Hong Kong• Japan - Kyoto University, Kyoto• Korea - Yonsei University Medical Center, Seoul• Lebanon - The American University in Beirut Faculty of

Medicine and Medical Center, Beirut• Taiwan - China Medical University Hospital, Taichung• Thailand – Chulalongkorn University• Turkey - Hacettepe University Institute of Oncology, Ankara• United Kingdom - Imperial College of London, London

Consortia• Italy – Italian Alliance Against Cancer• Japan - Tokyo Oncology Consortium - Keio University and

St. Luke’s International Hospital, Tokyo• Norway - Norwegian Cancer Consortium, Oslo including

Oslo University Radium Hospital, Stavanger University Hospital and the National Cancer Registry

• Poland - Polish Cancer Consortium• Thailand – Mahidol University, Siriraj Hospital and Bangkok

Hospital

Meet our Sister InstitutionsNational / Regional Cancer Centers or Equivalent• Australia - Peter MacCallum Cancer Centre, Melbourne• China – Hunan Cancer Hospital, Changsha, Hunan Province• France - Institut Gustave Roussy (IGR), Villejuif• Germany - German Cancer Research Center, Heidelberg• India - Tata Memorial Center, Mumbai• Jordan - King Hussein Cancer Center, Amman• Mexico - Instituto Nacional de Cancerologia, Mexico City• Peru - Instituto Nacional de Enfermedades Neoplásicas (INEN),

Lima• Sweden - Karolinska Institutet, Stockholm

Private Non-Profit Academic Hospitals with strong Cancer Programs• Brazil - Hospital Israelita Albert Einstein, Sao Paulo• Chile - Clinica Alemana, Santiago• Colombia - Instituto de Cancerología - Clinica Las Américas

(IDC), Medellin

Private Non-Profit Academic Cancer Hospitals• Brazil - Hospital de Câncer, A.C. Camargo, Sao Paulo• Brazil - Barretos Cancer Hospital, Barretos

Academic Hospitals with strong Cancer Programs• Denmark - Rigshospitalet, Copenhagen University Hospital,

Copenhagen• Israel - Chaim Sheba Medical Center, Tel Hashomer

Why Associate With MD Anderson?

UT MD Anderson

Part of Houston’s Texas Medical Center

• 53 health and academic institutions– UT Health & MD Anderson– Baylor College of Medicine– Rice University

• 106,000 employees• 7,000 beds• 7.2 million visitors/year• MD Anderson is the largest single

entity in the TMC• www.texasmedicalcenter.org

Part of the University of Texas• 9 academic institutions• 6 health institutions

– UT Southwestern Medical Center– UT Medical Branch at Galveston– UT Health Science Center at Houston– UT Health Science Center at San

Antonio– UT MD Anderson Cancer Center– UT Health Science Center at Tyler

Mission Driven

Patient Care

Prevention

Education

Research

Patient Care

Research

Research & Game Changing Initiatives

• Moon Shots: • Ambitious and comprehensive plan to

dramatically accelerate the pace of scientific discoveries into clinical advances, focused on six key areas: – breast & ovarian– lung– prostate– melanoma– leukemia (CLL)– leukemia (AML/MDS)

Education & Prevention

Departmental Structure

Clinical Divisions• Anesthesiology & Critical Care• Cancer Medicine• Cancer Prevention & Population

Science• Diagnostic Imaging• Internal Medicine• Nursing• Pathology/Laboratory Medicine• Pediatrics• Quantitative Sciences• Radiation Oncology• Surgery

research driven, multidisciplinary patient care

Basic Science Departments• Biochemistry & Molecular Biology• Biomedical Engineering • Cancer Biology• Cancer Genetics• Epigenetics & Molecular

Carcinogenesis• Immunology• Molecular & Cellular Oncology• Molecular Genetics• Veterinary Medicine & Surgery• Veterinary Sciences

Multi-Disciplinary Care Centers

• Bone Marrow/Stem Cell

• Brain and Spine• Breast • Gastrointestinal • Genitourinary• Gynecology

• Head and Neck• Leukemia• Lymphoma and

Myeloma• Melanoma/Skin • Sarcoma• Thoracic

research driven, multidisciplinary patient care

Sister Institution Membership

• Sister Institutions are academic partners with broad engagement across multiple areas/departments/disciplines

• Relationships built around faculty champions – “GAP follows the faculty”

• Relationships take 1-2 years to build• Thorough assessment of partner with reciprocal visits, seminars• Assess/score

various criteria• Presented to advisory

committee, which makes a recommendation to the President

• 5-year renewable agreement

Status in country/regionImpact & Significance of relationshipStrategic Plan for collaborationsBasis/activities already ongoingInfrastructure and capabilities of partnerFeasibility & institutional support

GAP Activities – Patient CareSister Institution Referral Assistance Center

• SIRAC Supports the collaborative management of patients from abroad, between our physicians and those at the home institution.

• SIRAC provides language and “concierge-light” services & community to those patients to ease their entry to MD Anderson’s International Center.

www.mdanderson.org/sirac

• ~110 patients / 3 years• Focus on China & Latin America• Recently added 2nd opinion pathology service

“Fudan University […] Tumor hospital and American MD Anderson Cancer Center [are] sisters hospital, [and] we have the treatment determination, [and] help to recommend the US to treat!!”

GAP Activities – ResearchSister Institution Network Fund

• 82 projects • 4 RFAs (FY11/12/13/14) • 47 collaborating institutions • 27 countries

Clinical

Basic

Total ~ $16M (MD Anderson: $8.2; Network ~ $8M)

Papers (71):• Nature (3), Nature Cell Biol. (4),

Nature Imm., NEJM, Cell, Mol. Cell, Dev. Cell, JNCI, PNAS

Grants (19):• NIH/NCI (11), CPRIT (6), ASCO,

Foundations

• 20+ cancer types• broad range of research• http://bit.ly/SINF_2014

“collaborate globally & fund

locally”

GAP Activities – ResearchSister Institution Network Fund

What are the projects focused on?

1999

2000

2001

2002

2003

2004

2005

2006

2007

2008

2009

2010

2011

2012

2013

2014

0

50

100

150

200

250

6 7 9 14 2336

4961 64

112 116137

204221 231

204

Co-Publications between MD Anderson and Sister Institutions

Num

ber o

f Pub

licat

sions

in S

COPU

SGAP Activities – Research

Publications

Data obtained from SCOPUS - www.mdanderson.org/scival

GAP started

SINF started

Global Cancer Collaboration MapNCI initiative to coordinate global engagement

http://gcpm.globalonc.org/

GAP Activities – ResearchClinical Trials

• In 2011 gathered an “inventory” of the capabilities of 17 of our Sister Institutions regarding clinical trials – shared this internally with clinical investigators

• With Institute De Cancerologia, Clinica Las Americas, Medellin, Colombia:• *Conservative surgery for women with low-risk, early cervical cancer• *Laparoscopic approach to cervical carcinoma: a phase III randomized clinical trial of

laparoscopic or robotic radical hysterectomy versus abdominal radical hysterectomy in patients with early stage cervical cancer

• With Fudan University Cancer Center, Shanghai, China:• External qigong therapy for women with breast cancer prior to surgery• Pilot study of Huachansu in patients with hepatocellular carcinoma, small cell lung cancer or

pancreatic cancer (Phase I)• *Huachansu and gemcitabine in pancreatic cancer (Phase II)

• With Sheba Medical Center, Tel Hashomer, Israel & University of Heidelberg, Germany:• A phase I, open-label, dose escalation study to evaluate the safety, tolerability and

pharmacokinetics of INNO-406 in adult patients with Imatinib-resistant or intolerant Ph+ leukemias

• With Institute Gustave Roussy, Paris, France:• A phase II trial of the multitargeted kinase inhibitor E7080 in advanced radioiodine (RAI)

refractory differentiated thyroid cancer (DTC)

Total: 7 trials (*3 are ongoing)

GAP Activities – PreventionTobacco Control with Moon Shots Platform

Nov. 2012 – LOI signed by the Commission of National Institutes and High Specialty Hospitals of Mexico, the National Cancer Institute of Mexico and MD Anderson Cancer Center (picture)

Oct. 2013 – LOI signed by the Government of the City of Medellin, the Instituto de Cancerologia Clinica las Americas and MD Anderson Cancer Center

The implementation, evaluation, refinement and dissemination of prevention and control programs:• community-based tobacco use prevention and control pilot programs for

children and adolescents• formalized prevention and control programs, including programs related to

public health policy, education for the public and professionals, clinical and community services, comprehensive initiatives, research endeavors, and other public health and academic programs

GAP Activities – EducationAnnual GAP Conference

Conference held at MD Anderson in odd years and hosted by a Sister Institution in even years. 2012 - Norwegian Cancer Consortium and 2014 - Yonsei Cancer in Seoul, South Korea.

• Global Participation• Program built to

foster collaboration• Brings entire

network together

www.MDAnderson.org/GapConference

Norway

Korea

http://gapbrazil2016.org/

GAP Activities – EducationVisitors, Video-Conferences, Conferences

multidisciplinary patient video conference

Institutional Investment• Organization and governance

– Part of Division of Academic Affairs, reports through Provost– 10 team members in GAP office

• GAP is a significant institutional investment– SINF & GAP Conference supported by the MD Anderson Cancer Foundation

(unrestricted donor funds); SINF some support from the National Breast Cancer Foundation.

• Return on investment– SINF:

• leverages from network at 1:1• $14M in new grants from NCI/NIH, CPRIT, foundations etc have been obtained in

connection with SINF grants (updated 4/15)– SIRAC supported >120 patients who gained access to expertise, technology

and drugs not available in their home country– GAP activity has resulted in Cancer Network projects e.g. at Hospital Israelita

Albert Einstein, Sao Paulo; GAP provides academic component for Cancer Network activities

Program Stewardship and Integration

GAPMD Anderson Faculty

– “GAP follows the faculty”

International Advisory BoardMD Anderson

Committee

Sister Institution Directors

Presidents/CEOs/Representatives of

the Sister Institutions

Sister Institution Network Fund• Study Section• Sister Institution

Program Board

International Advisory

Board

GAP

Business Development

International Fund Raising Development

Office

Other programs

GAP Directors Meeting, April 2015

MD Anderson +

Sister Institutions+

Partners

Onsite Workshops

Observerships / Fellowships

Online Teaching / Telementoring

Train 1000 healthcare providers over the next 5 years

Africa Initiative

5 African PG Trainees, New Oncology Masters Program, 2 SINF grants, 1 NCI grant, Multi-disciplinary Onc Seminars

Telementoring for Women’s Cancer with Project Echo (MDACC, Barretos & HIAE)

March 2015: 1st In-Country Workshop w/MOH- Zambia with all the partners shown above

3yr Training & Education Plan developed focused on breast and cervical cancer, including telementoring, rotations, fellowships etc

Ultimately also aim to develop research infrastructure

RecognitionMD Anderson Cancer Center was presented the People’s Republic of China International Science and Technology Cooperation Award at a ceremony held January 9, 2015 at Beijing’s Great Hall of the People.

“It is increasingly important to share information and create ties that help all nations in our collective fight against cancer. Receiving this coveted award from China is an honor for our institution and one that speaks to our commitment to collaboration, here at home and across the globe.”- Ron DePinho, M.D., President of MD Anderson