genetic predictors of weight loss and weight regain after intensive lifestyle
DESCRIPTION
Featured Article :. Genetic Predictors of Weight Loss and Weight Regain After Intensive Lifestyle Modification,Metformin Treatment, or Standard Care in the Diabetes Prevention Program. - PowerPoint PPT PresentationTRANSCRIPT
![Page 1: Genetic Predictors of Weight Loss and Weight Regain After Intensive Lifestyle](https://reader035.vdocuments.mx/reader035/viewer/2022070502/56814bfe550346895db8fd6e/html5/thumbnails/1.jpg)
Genetic Predictors of Weight Loss andWeight Regain After Intensive Lifestyle
Modification,Metformin Treatment,or Standard Care in the Diabetes
Prevention Program
Featured Article:
Linda M. Delahanty, M.S., R.D., Qing Pan, Ph.D., Kathleen A. Jablonski, Ph.D., Karol E. Watson, M.D., Ph.D., Jeanne M. McCaffery, Ph.D., Alan Shuldiner, M.D., Steven E. Kahn, M.B., ChB., William C. Knowler, M.D., Dr.PH, Jose C. Florez, M.D., Ph.D., Paul W. Franks, Ph.D., M.Phil, M.S., FOR THE DIABETES PREVENTION PROGRAM RESEARCH GROUP*
Diabetes Care Volume 35:363–366
February, 2012
![Page 2: Genetic Predictors of Weight Loss and Weight Regain After Intensive Lifestyle](https://reader035.vdocuments.mx/reader035/viewer/2022070502/56814bfe550346895db8fd6e/html5/thumbnails/2.jpg)
Study Objective
• To test genetic associations with weight loss and weight regain in the Diabetes Prevention Program
Delahanty L et al. Diabetes Care 2012;35:363-366
![Page 3: Genetic Predictors of Weight Loss and Weight Regain After Intensive Lifestyle](https://reader035.vdocuments.mx/reader035/viewer/2022070502/56814bfe550346895db8fd6e/html5/thumbnails/3.jpg)
Study Design
• 16 obesity-predisposing SNPs tested for association with short-term (baseline to 6 months) and long-term (baseline to 2 years) weight loss and weight regain (6 months to study end).
Delahanty L et al. Diabetes Care 2012;35:363-366
![Page 4: Genetic Predictors of Weight Loss and Weight Regain After Intensive Lifestyle](https://reader035.vdocuments.mx/reader035/viewer/2022070502/56814bfe550346895db8fd6e/html5/thumbnails/4.jpg)
Delahanty L et al. Diabetes Care 2012;35:363-366
![Page 5: Genetic Predictors of Weight Loss and Weight Regain After Intensive Lifestyle](https://reader035.vdocuments.mx/reader035/viewer/2022070502/56814bfe550346895db8fd6e/html5/thumbnails/5.jpg)
Conclusion
•Genetic information may help identify people who require additional support to maintain reduced weight after clinical intervention
Delahanty L et al. Diabetes Care 2012;35:363-366