gène commun toucher - audition - a genetic basis for mechanosensory traits in humans

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    L Jhmhq`b Klr`r fe{ Nhbclmerhmre{p Q{l`qr

    `m Cxnlmr

    cqqp7%%zzz-pierk`eiej-e{j%l{q`bih%`mfe7ae`%

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    bembh`vlki mhjlq`vhi mfixhmbh qexbc rhmr`q`v`q- @m lj{hhnhmq z`qc qc`r cpeqchr`r zh fexma

    qclq l p{epe{q`em ef l bece{q ef bemjhm`qlii ahlf exmj laxiqr a`rpil r`jm`f`blmqi `npl`{ha

    nhlrx{hr ef qexbc rhmr`q`v`q benpl{ha qe bemq{eir- @m bemq{lrq ki`ma `ma`v`axlir rcezha

    hmclmbha meq a`n`m`rcha qexbc lbx`q- F`mlii k hsln`m`mj l bece{q ef plq`hmqr z`qc Xrch{

    rma{enh l jhmhq`blii zhii.bcl{lbqh{`wha ahlf.ki`mamhrr rma{enh zh bexia rcez qclq

    {hbhrr`vh plqcejhm`b nxqlq`emr `m qch XRC;L jhmh `mfixhmbh qexbc lbx`q- Bemq{ei Xrch{rma{enh bece{qr ilbd`mj ahnemrq{lkih plqcejhm`b XRC;L nxqlq`emr rcezha me `npl`{nhmq

    `m qexbc lbx`q- Ex{ rqxa qcxr p{ev`ahr benp{hchmr`vh hv`ahmbh qclq qch{h l{h bennem

    jhmhq`b hihnhmqr qclq bemq{`kxqh qe qexbc lma chl{`mj lma clr `ahmq`f`ha emh ef qchrh jhmhr lr

    XRC;L-

    Lxqce{ Rxnnl{Qep

    @m cxnlmr nlm jhmhr clvh khhm `ahmq`f`ha qclq blxrh ahlfmhrr zchm nxqlqha kxq me

    h|x`vlihmq jhmhr clvh khhm ahmq`f`ha qclq l{h {h|x`{ha fe{ qexbc- Ch{h zh lrdha zchqch{ jhmhr

    qclq `mfixhmbh chl{`mj blm lire `mfixhmbh qexbc- Xr`mj `ahmq`bli lma mem.`ahmq`bli cxnlm qz`mr`q zlr perr`kih qe rcez qclq qexbc ph{fe{nlmbh `r rxkrqlmq`lii `mfixhmbha k jhmhr-

    Fx{qch{ne{h phepih zce clvh hsbhiihmq chl{`mj l{h ne{h i`dhi qe clvh l f`mh rhmrh ef qexbc

    lma v`bh vh{rl- @mqh{hrq`mji phepih zce rxffh{ f{en bemjhm`qli ahlfmhrr clvh l c`jch{ bclmbh

    ef clv`mj pee{ qexbc ph{fe{nlmbh- @m l jhmhq`blii ahf`mha fe{n ef cxnlm ahlfmhrr Xrch{

    rma{enh qph @@ l r`mjih nxqlqha jhmh zlr `ahmq`f`ha qclq lire `npl`{r qexbc- Qexbc lma

    chl{`mj l{h qcxr `mq{`blqhi `mqh{qz`mha lma qch{h nl kh eqch{ qexbc%chl{`mj jhmhr zl`q`mj qe

    kh a`rbevh{ha-

    B`qlq`em7 F{hmwhi C Kecihmah{ G _`mrdh{ D Zeciihkhm K Qlmd G hq li- #;?

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    a`ffh{hmbhr4 { be{{hilq`em behff`b`hmq4 RA rqlmal{a ahv`lq`em4 RM_ r`mjih mxbiheq`ah

    peine{pc`rn4 VAQ v`k{lq`em ahqhbq`em qc{hrceia

    ' H.nl`i7jihz`mOnab.kh{i`m-ah

    @mq{eaxbq`emQep

    Lii lm`nlir l{h h|x`ppha z`qc l {lmjh ef rphb`li`wha rhmre{ bhiir zcerh p{`nh fxmbq`em `r qe

    ahqhbq nhbclm`bli fe{bh- Qch nerq fln`i`l{ ef qchrh rhmre{ rrqhnr l{h chl{`mj lma qexbc kxq

    nhbclmerhmre{ bhiir lire ahqhbq `npe{qlmq rq`nxi` qclq l{h meq bemrb`exri ph{bh`vha fe{

    hslnpih bclmjhr `m kieea p{hrrx{h- Zh {hlremha qclq r`mbh qch p{`nh fxmbq`em ef a`ffh{hmq

    rhmre{ bhiir `r qe ahqhbq nhbclm`bli fe{bh qch nl xq`i`wh l bennem rhq ef nhbclmerhmre{

    p{eqh`mr fe{ qc`r fxmbq`em- Lbbe{a`mj qe qc`r cpeqchr`r jhmhq`b vl{`lq`em lffhbq`mj qch fxmbq`em

    ef nhbclmerhmre{ p{eqh`mr zexia kh p{ha`bqha qe |xlmq`qlq`vhi bclmjh ne{h qclm emh

    nhbclmerhmre{ q{l`q- Jhmhq`br clr khhm vh{ rxbbhrrfxii xrha qe bcl{lbqh{`wh mhz neihbxihr

    qclq l{h hrrhmq`li fe{ cxnlm chl{`mjT

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    `r re fl{ ilbd`mj- Kxq lrrxn`mj qclq qexbc rhmr`q`v`q `r l benpihs jhmhq`b q{l`q `q rcexia kh

    perr`kih qe ahqhbq l ch{`qlkih benpemhmq `m qch me{nli vl{`lq`em ef qexbc.{hilqha q{l`qr lr clr

    khhm rcezm khfe{h fe{ eqch{ rhmre{ q{l`qr rxbc lr pl`m rhmr`q`v`q lma chl{`mjT

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    Qlkih

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    Qch ch{`qlk`i`q c; ef qch `mvhrq`jlqha rhmre{ q{l`qrqclq `r qch benpemhmq ef qch vl{`lq`em ef

    qch {hrphbq`vh q{l`q qclq blm kh lbbexmqha fe{ k laa`q`vh jhmhq`b hffhbqrzlr ahqh{n`mha `m l

    bilrr`bli qz`m rqxa- Ef qch

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    Fe{ lii qc{hh chl{`mj q{l`qr qch b{err.qz`m be{{hilq`emr zh{h ne{h qclm qz`bh lr rq{emj `m qch

    nemewjeq`b qz`m pl`{r benpl{ha qe a`wjeq`b qz`m pl`{r z`qc c`jc evh{lii be{{hilq`emr #F`jx{h

    ;Qlkih R2)- Qch ch{`qlk`i`q hrq`nlqhr zh{h hsbhpq`emlii c`jc ?-3? #08( B@ > ?-6:?-3:) fe{

    chl{`mj lbx`q ?-:6 #08( B@ > ?-6;?-38) fe{ HELH {hp{eaxb`k`i`q lma hvhm ?-33 #08( B@

    > ?-3??-02) fe{ HELH rq{hmjqc- Fe{ lii qc{hh chl{`mj q{l`qr qch LH neahi khrq ahrb{`kha qch

    alql lma zlr xrha qe hrq`nlqh qch ch{`qlk`i`q-

    F`jx{h ;- B{err.qz`m be{{hilq`emr lma

    ch{`qlk`i`q hrq`nlqhr ef chl{`mj q{l`qr-

    Fe{ lii qc{hh chl{`mj q{l`qrpx{h qemh

    qc{hrceiar #L) eqelbexrq`b hn`rr`em

    {hp{eaxb`k`i`q #K) lma eqelbexrq`b

    hn`rr`em rq{hmjqc #B)b{err.qz`mbe{{hilq`emr zh{h c`jch{ `m NW qclm `m AW

    qz`mr lma vh{ c`jc ch{`qlk`i`q vlixhr bexia

    kh hrq`nlqha- { `mq{l.bilrr be{{hilq`em4 c;

    ch{`qlk`i`q hrq`nlqh4 08( bemf`ahmbh

    `mqh{vli `m k{lbdhqr4 LH p{hfh{{ha neahi

    xrha qe hrq`nlqh ch{`qlk`i`q-

    ae`7

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    F`jx{h 2- B{err.qz`m be{{hilq`emr lma

    ch{`qlk`i`q hrq`nlqhr ef kl{e{hfihs q{l`qr-

    Fe{ keqc kl{e{hfihs q{l`qrkl{e{hfihsrh|xhmbh rieph #L) lma kl{e{hfihs rh|xhmbh

    f{h|xhmb #K)qch b{err.qz`m be{{hilq`emr

    zh{h c`jch{ `m NW qclm `m AW qz`mr-

    R`jm`f`blmq ch{`qlk`i`q hrq`nlqhr bexia kh

    blibxilqha- { `mq{l.bilrr be{{hilq`em4 c;

    ch{`qlk`i`q hrq`nlqh4 08( bemf`ahmbh

    `mqh{vli `m k{lbdhqr4 LH p{hfh{{ha neahi

    xrha qe hrq`nlqh ch{`qlk`i`q-

    ae`7

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    F`jx{h 1- B{err.qz`m be{{hilq`emr lma

    ch{`qlk`i`q hrq`nlqhr #zch{h lppi`blkih)

    ef qhnph{lqx{h rhmr`q`v`q q{l`qr-

    Fe{ lii q{l`qr hsbhpq qch beia pl`m qc{hrceia

    qch b{err.qz`m be{{hilq`emr zh{h c`jch{ `m

    NW qclm m AW qz`mr- R`jm`f`blmq ch{`qlk`i`q

    hrq`nlqhr bexia kh blibxilqha fe{ beia #L)

    lma zl{nqc #K) ahqhbq`em qc{hrceiar

    zch{hlr fe{ qch chlq #B) lma beia #A) pl`m

    qc{hrceiar qch BH neahi meq bemql`m`mj l

    ch{`qlkih benpemhmq zlr p{hfh{{ha- { `mq{l.

    bilrr be{{hilq`em4 c; ch{`qlk`i`q hrq`nlqh4

    08( bemf`ahmbh `mqh{vli `m k{lbdhqr4

    LH%BH p{hfh{{ha neahi xrha qe hrq`nlqhch{`qlk`i`q-

    ae`7

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    ahqhbq`em qc{hrceia z`qc {> ?-#nhlm fhnlih vlixhnhlm nlih vlixh)$nhlrx{ha nlih vlixh- Lfqh{ qch {lz alql zh{h lagxrqha

    `m qc`r zl lma mqh{neali be{{hilq`emr qhrqha ljl`m qch emi rqlq`rq`blii r`jm`f`blmq be{{hilq`em

    qclq {hnl`mha zlr khqzhhm qlbq`ih lbx`q lma chl{`mj lbx`q z`qc {> ?-

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    Zh lrdha `f qexbc rhmr`q`v`q n`jcq kh lffhbqha `m renh fe{nr ef ch{ha`ql{ chl{`mj ierr- Zh

    qhrqha qexbc rhmr`q`v`q `m l bece{q ef `ma`v`axlir ljha khqzhhm

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    Ex{ alql re fl{ rq{emji rxjjhrqha qclq jhmhq`b flbqe{r qclq `mfixhmbh chl{`mj nl lire mfixhmbh

    qexbc- @ahlii emh zexia i`dh qe `ahmq`f rxbc jhmhr k nhlrx{`mj qexbc ph{fe{nlmbh `m

    plq`hmqr z`qc r`mjih jhmh nxqlq`emr qclq blxrh ahlfmhrr lma ahb{hlrh qexbc rhmr`q`v`q- Zh

    ahb`aha qe {hb{x`q plq`hmqr z`qc Xrch{ rma{enh qe pl{q`b`plqh `m ex{ rqxa- Xrch{ rma{enh `r

    bcl{lbqh{`wha k hl{i emrhq ahlfmhrr z`qc ilqh emrhq {hq`m`q`r p`jnhmqerl ihla`mj qe qxmmhi

    v`r`em lma ki`mamhrr lma blm kh bilrr`f`ha `mqe qc{hh bi`m`bli rxk.qphr z`qc qph < #XRC

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    qch bemq{ei bece{q #A) lma v`k{lq`em ahqhbq`em qc{hrceiar zh{h meq r`jm`f`blmqi a`ffh{hmq #B)-mr meq r`jm`f`blmq4 'p9?-?8 Rqxahmq*r qqhrq-

    ae`7

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    F`jx{h 3- Qexbc rhmr`q`v`q `m l bece{q ef

    K{l`iih {hla`mj ki`ma phepih-

    Qch v`k{lq`em ahqhbq`em qc{hrceia zlr meqa`ffh{hmq `m benpl{`rem qe l bemq{ei bece{q

    kxq qch qlbq`ih lbx`q zlr r`jm`f`blmqi c`jch{

    `m qch ki`ma bece{q- '''p9?-??

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    lma zh f`ma r`jm`f`blmq ch{`qlk`i`q keqc fe{ zl{nqc lma beia ahqhbq`em qc{hrceiar # c; > ?-2:

    lma c; > ?-1? {hrphbq`vhi)-

    Qz`m rqxa`hr clvh p{hv`exri khhm xrha qe rcez qclq chl{`mj lbx`q `r c`jci ch{`qlkih `m

    n`aaih.ljha lma hiah{i ph{remrT1 ?-3??-02 benpl{ha qe qch ?-68?-38 {hpe{qha k NbFlaahmT16^)

    #F`jx{h ;)- Qch lbq`v`q ef qch kl{e{hfihs `m {hrq`mj pl{q`b`plmqr clr lire khhm rcezm qe kh

    ch{`qlkih `m l qz`m rqxaT12^ lma zh bexia bemf`{n qc`r ch{h `m lm `mahphmahmq bece{q #F`jx{h

    2)- Chlq pl`m qc{hrceiar clvh khhm {hpe{qha qe kh ch{`qlkih `m l qz`m rqxaT

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    qclq renlq`b rhmre{ mhx{emr {h|x`{h b`i`l fe{ qch`{ fxmbq`em lma re ierr ef chl{`mj jhmh fxmbq`em

    bexia lbq lq nlm eqch{ ihvhir- @m qch blrh ef ilqh emrhq ahlfmhrr blxrha k aen`mlmq mhjlq`vh

    nxqlq`emr `m qch jhmh hmbea`mj qch peqlrr`xn `em bclmmhi p{eqh`m DBM\1 #AFML;.qph

    nemejhm`b chl{`mj ierr) cl`{ bhiir ahjhmh{lqh lppl{hmqi axh qe rxrql`mha ahpeil{`wlq`emT10^-

    Zh clvh {hbhmqi rcezm qclq qch DBM\1 p{eqh`m clr l rphb`li`wha {eih `m qch q{lmrfe{nlq`em

    ef {hbhpqe{ peqhmq`lir `mqe lbq`em peqhmq`lir `m rphb`f`b qphr ef nhbclme{hbhpqe{r T8?^-Fx{qch{ne{h ierr ef DBM\1 fxmbq`em `r lrreb`lqha z`qc khqqh{ v`k{lq`em ahqhbq`em qc{hrceia

    ph{fe{nlmbh kxq emi lq iez v`k{lq`em f{h|xhmb`hrT8?^- Renh chl{`mj jhmhr clvh lire khhm

    rcezm qe lffhbq rmlprhr nlah khqzhhm qch cl`{ bhii lma qch rhmre{ lffh{hmqr qclq bemvh qch

    lxa`qe{ r`jmlir qe qch k{l`m T8

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    Cxnlm XRC;L `r lm hsq{le{a`ml{`i il{jh jhmh bemr`rq`mj ef :; hsemr zc`bc blm hmbeah l

    p{eqh`m z`qc l ihmjqc ef 8;;; ln`me lb`ar T6;^- Rhvh{li a`ffh{hmq q{lmrb{`pqr clvh khhm

    `ahmq`f`ha fe{ qch XRC;L jhmh lma re `q `r bembh`vlkih qclq nxqlq`emr `m qc`r jhmh nl clvh

    a`ffh{hmq`li hffhbqr em p{eqh`m p{eaxbqr hsp{hrrha `m a`ffh{hmq q`rrxhr #h-j- cl`{ bhiir vh{rxr

    rhmre{ mhx{emr)- Nerq plq`hmqr `m zc`bc emh plqcejhm`b XRC;L nxqlq`em clr khhm `ahmq`f`ha

    l{h p{eklki lire bl{{`h{r ef l rhbema nxqlq`em `m qch rlnh jhmh T63^- Bemr`rqhmq z`qc qc`rp{ha`bq`em zh ekrh{vha qclq l n`sha bece{q ef plq`hmqr cenewjexr e{ chqh{ewjexr fe{

    plqcejhm`b XRC;L nxqlq`emr lire hsc`k`qha `npl`{ha qexbc rhmr`q`v`q liqcexjc qc`r

    a`ffh{hmbh zlr meq rqlq`rq`blii r`jm`f`blmq- @mqh{hrq`mji nlm `ma`v`axlir z`qc Xrch{

    rma{enh qph @@ m ex{ rqxa a`a meq hsc`k`q npl`{ha qexbc lbx`q liqcexjc p{hv`exr lmlirhr

    ef il{jh pepxilq`emr ef qchrh plq`hmqr clvh p{ev`aha hrq`nlqhr qclq qch nlge{`q #xp qe :?()

    nl bl{{ plqcejhm`b nxqlq`emr `m qch XRC;L jhmhT22^T60^T:?^- @mqh{hrq`mji Xrch{ qph ;

    plq`hmqr fe{ zc`bc me nxqlq`em `m qch XRC;L zlr dmezm ph{fe{nha em lvh{ljh khqqh{ `m qch

    qexbc lbx`q qhrq qclm bemq{eir #F`jx{h :A)- Qchrh plq`hmqr lire rxffh{ha f{en v`rxli

    `npl`{nhmq lma `q `r perr`kih qclq qch i`dh ki`ma phepih cla ihl{mha qe `np{evh qch`{ qlbq`ih

    lbx`q- Nxqlq`em `m qze eqch{ jhmhr ZC[Mlma VIJ[

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    lppi`ha khiez qch ml`i ef qch i`qqih f`mjh{- Qe p{hvhmq perr`kih lxa`qe{ ahqhbq`em ef qch v`k{lq`em

    rq`nxilqe{ #me{nli chl{`mj) qhrq ph{remr ze{h chlapcemhr zc`bc p{eaxbha l iez bemq`mxexr

    qemh ax{`mj qch qhrq- L r`mxre`ali

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    lmlirhr zh{h aemh xr`mj qch _V.zlvh refqzl{h #V`rxliMxnh{`br)- Rh|xhmbhr ef lq ihlrq qc{hh

    bexpiha n`m`nxn rqhpr ef ?-8 nnCj K_ bclmjhr lma 8 nr [[mqh{vli bclmjhr z`qc

    n`m`nxn be{{hilq`em behff`b`hmqr ef ?-38 zh{h ahqhbqha lma qch`{ riephr qldhm lr qch kl{e{hfihs

    rhmr`q`v`q `m nr%nnCj- Kieea p{hrrx{h ihvhir zh{h liiezha fe{ k {hj{hrr`em fe{ keqc

    kl{e{hfihs rh|xhmbh rieph lma f{h|xhmb khfe{h lmlir`r ef ch{`qlk`i`q e{ pchmeqp`b

    be{{hilq`emr-

    Qhnph{lqx{h Rhmr`q`v`q Qhrqr

    Qhnph{lqx{h rhmr`q`v`q zlr ahqh{n`mha xr`mj qch QRL.@@ Rrqhn #Nhaeb lavlmbha nha`bli

    rrqhnr) lbbe{a`mj qe qch nlmxflbqx{h{*r `mrq{xbq`emr- Qch qc{hrceiar zh{h ahqh{n`mha xr`mj

    qch lrbhma`mj nhqcea ef i`n`qr- L phiq`h{ qch{neah #2 bn2 bn) zlr pilbha `m qch n`aaih ef

    qch veil{ fe{hl{n- Qch klrhi`mh qhnph{lqx{h fe{ lii fex{ qhrqr zlr 2;B lma qch qhnph{lqx{h

    bclmjh {lqh zlr ?-8B%r- @m qch qhnph{lqx{h bclmjh ahqhbq`em qhrqr qch qhrq ph{remr `ma`blqha

    zchm qch fhiq l bclmjh `m rd`m qhnph{lqx{h- Fe{ zl{n`mj lma beei`mj {lnpr qch nhlm ef fex{

    qc{hrceiar zlr blibxilqha- @m qch qhnph{lqx{h pl`m qc{hrceia qhrqr qch qhrq ph{remr `ma`blqha

    zchm l {`r`mj e{ flii`mj qhnph{lqx{h khblnh pl`mfxi- Ch{h qch nhlm ef qc{hh qc{hrceiar zlrblibxilqha-

    Ch{`qlk`i`q lma Rqlq`rq`bli Lmlir`r

    Ch{`qlk`i`q #c;) hrq`nlqhr zh{h blibxilqha k rq{xbqx{li h|xlq`em neahi`mj xr`mj qch Ns

    refqzl{hT;:^- Lq f`{rq ch{`qlk`i`q`hr zh{h hrq`nlqha m lm LBH neahi m zc`bc qch vl{`lq`em ef

    l q{l`q `r benperha ef qch vl{`lq`emr ef laa`q`vh jhmhq`b hffhbqr #L) rcl{ha hmv`{emnhmq hffhbqr

    #B) lma xm`|xh hmv`{emnhmq hffhbqr #H)4 lbbe{a`mji qch be.vl{`lq`em ef l q{l`q khqzhhm

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