gender differences in attitudes and practices toward body skin care
Post on 25-Oct-2016
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P1626Clinical efficacy and tolerance of a novel treatment serum for photo-damaged facial skin
Nathan Trookman, Colorado Springs Dermatology Clinic, Rocky Mountain LaserCenter, PC, Colorado Springs, CO, United States; Elizabeth Ho, SkinMedica, Inc,Carlsbad, CA, United States; Ronald Rizer, PhD, Thomas J. Stephens & Associates,Inc, Colorado Springs, CO, United States; Rosanne Ford, SkinMedica, Inc,Carlsbad, CA, United States; Vincent Gotz, MS, SkinMedica, Inc, Carlsbad, CA,United States
Oxidative damage induced by environmental factors, such as chronic ultravioletexposure, contributes to the process of photoaging and results in the formation ofreactive oxygen species (ROS). At a molecular level, ROS causes a cascade ofbiochemical events which leads to increased collagen degradation and the suppres-sion of collagen synthesis. Clinical manifestations of photodamage include a loss ofskin elasticity and firmness, fine lines and wrinkles, and uneven skin tone. Topicaltherapies formulated with peptides and antioxidants have been shown to increasecollagen levels in the skin. In addition, emerging treatments using human growthfactors have been shown to stimulate repair of dermal structures. To treat the effectsof photodamage, an innovative treatment serum was formulated containing aconcentrated antioxidant blend, multiple human growth factors and cytokines,collagen-building peptides and de-pigmenting agents. A single-center controlledusage study was conducted to determine if the treatment serum could improve thevisible signs of facial photodamage. Thirty-seven females 32 to 55 years of age withmild, moderate, or severe fine and coarse periocular wrinkles were enrolled.Subjects applied the treatment serum twice daily in conjunction with a basicskincare regimen including sun protection. Baseline and week 4 visits includedinvestigator assessments of fine and coarse wrinkles, skin texture, tone, andradiance. In addition, cutometer measurements of skin firmness, digital photogra-phy, tolerability assessments, and subject questionnaires were conducted. After 4weeks of treatment, statistically significant improvements were observed in allinvestigator assessments of fine and coarse periocular wrinkles, skin texture, tone,and radiance (all P # .0001). Cutometer readings also reflected significantimprovements in skin firmness (P ¼ .002). Digital photography confirmed thesignificant improvements seen in investigator assessments and cutometer readings.The treatment serum was well tolerated and no treatment-related adverse eventswere reported. The treatment serum was highly rated in product efficacy, asreflected in subject assessments. Results from this study show that this noveltreatment serum provided significant improvements in the visible signs ofphotodamage.
MARCH 2
cial support: 100% sponsored by SkinMedica, Inc.
CommerP1627Facial tolerance of a daily moisturizer containing a purified feverfewextract and SPF30 in a sensitive skin population
Warren Wallo, Johnson & Johnson Consumer & Personal Products Worldwide,Skillman, NJ, United States; Dara Miller, Johnson & Johnson CPPW, Skillman, NJ,United States; Judith Nebus, MBA, Johnson & Johnson CPPW, Skillman, NJ,United States
Patients with sensitive skin struggle to find skin care products that they can tolerateand will not irritate their skin. At the same time, these patients need to use a dailyproduct that provides effective protection from photodamage. Dermatologistsreinforce the need for broad-spectrum, ultraviolet A and B light, photostablesunscreen with a preferred SPF of 30. To provide additional benefits to patients withsensitive skin, specific naturally derived extracts can be included in topicalformulations to provide additional calming benefits, improving patient tolerabilityand daily compliance. A 4-week clinical facial study including daily application of acalming moisturizer with SPF 30 was conducted on 30 female subjects with self-assessed or clinically-defined sensitive skin. Tolerance and product performance wasassessed by investigator clinical evaluations and patient self-assessments at multipletime points over the course of the study. After 4 weeks of daily use of the feverfew-containing moisturizer with SPF30, patients exhibited statistically significantimprovements versus baseline in their facial erythema, dryness, and roughnessand in the overall appearance of their skin as graded by the investigator. There wereno statistically significant increases in facial irritation observed during the study.Subjects did not perceive any significant increases in sensory irritation parametersand self-assessments indicated that patients perceived improvements in their overallappearance and skin texture. In conclusion, a daily moisturizer with SPF30containing a purified feverfew extract has been shown to be well tolerated bypatients with sensitive skin, provided a high level of photostable sun protection, anddelivered improvements in overall appearance and texture while calming andsoothing their sensitive skin.
cial support: 100% sponsored by Johnson & Johnson Coes, Inc.
Commer nsumerCompani
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P1628Evaluating the effects of a body moisturizer with glycolic acid on epider-mal proliferation via fluorescence excitation spectroscopy
Michael Suero, MBChB, Johnson & Johnson Consumer Products Worldwide,Skillman, NJ, United States; Dara Miller, Johnson & Johnson Consumer ProductsWorldwide, Skillman, NJ, United States; Merryl Azriel, Johnson & JohnsonConsumer Products Worldwide, Skillman, NJ, United States; Warren Wallo, MS,Johnson & Johnson Consumer Products Worldwide, Skillman, NJ, United States
In a clinical setting, patients with dry skin often present with flakiness as a result of adisrupted desquamation process. The application of an exfoliating agent such as alfa-hydroxy acid (AHA) helps promote desquamation by breaking the bonds betweendead skin cells, thereby facilitating the removal of flakes and allowing newer cells toemerge. Fluorescence excitation spectroscopy allows for a noninvasive means ofdetermining the increase in the rate of cellular turnover via monitoring theintensities of the excitation band assigned to tryptophan, an established marker ofepidermal proliferation. A randomized, controlled clinical study was performed on25 healthy women between 40 and 59 years of age in order to evaluate the efficacy ofa new moisturizer formulated with 4% glycolic acid in increasing the rate of cellularturnover compared to an ordinary body lotion. Subjects applied one test product onone forearm and the second test product on the other forearm twice daily for 4weeks. Product efficacy was determined via fluorescence excitation scans of thevolar forearms at various time points over the 4-week period. An increase in theintensity at 295 nm signaled an increase in tryptophan and therefore proliferationrate. In as early as 1 week, the forearms treated with the new moisturizer with 4%glycolic acid exhibited fluorescence intensity increases that were significantlyhigher compared to those of the ordinary body lotion and untreated test site.Moreover, none of the subjects experienced any form of irritation on the treatedsites. In conclusion, this clinical study demonstrated that daily topical application ofa body moisturizer with 4% glycolic acid is well tolerated and effective inaccelerating cellular turnover and reducing flakiness associated with dry skin.Clinicians can apply this noninvasive methodology to measure proliferation ratesand obtain objective instrumental results to correlate with visual and texturalchanges observed on the cutaneous surface.
cial support: Sponsored by Johnson & Johnson Consumer Pe.
Commer roductsWorldwid
P1629Gender differences in attitudes and practices toward body skin care
Keith Ertel, MD, MPH, The Procter & Gamble Company, Cincinnati, OH, UnitedStates; Christina Dooley, The Procter & Gamble Company, Cincinnati, OH,United States; Heather Focht, The Procter & Gamble Company, Cincinnati, OH,United States; Jamie Moak, The Procter & Gamble Company, Cincinnati, OH,United States
Background: Female patients are the traditional focus for skin care product researchand development. This is because females are an easier test population, females aremore skin involved than males, and females purchase more products than males.However, males and females share baser skin care needs, such as those relating todry skin and moisturization, yet sex differences in skin physiology may provide abasis for gender-specific formulations.
Objective: This work assessed male and female views regarding skin care needs andtheir attitudes toward various treatment modalities.
Methods: This research was conducted on a study panel consisting of 303 males and313 females. Subjects completed a questionnaire regarding perceptions of body skincondition, skin care habits and practices, and attitudes toward various cosmeticinterventions. A 10% significance level, standard for this type of research, was usedfor comparisons.
Results: This research showed a strong contrast between males and females in theiruse of body skin care products. Males were less likely to use a body treatmentproduct than females. However, dry skin ranked high on the list of body skin careneeds for both sexes. Moisturizer use was identified as the best dry skin treatment,but males were less likely to apply moisturizer because of perceived a timeconstraint (P \.10). Skin-feel parameters were also more important to males thanfemales (P \ .10). Surprisingly, males were more likely to seek help from adermatologist for their dry skin than females (P \.10).
Conclusion: These results demonstrate a need for male-oriented dry skin treatmentsand suggest that moisturizers, moisturizing body cleansers, or in-shower bodylotions should be developed with acceptable aesthetics. Further, the results showthat dermatologists can play an important role in educating male patients on theimportance of proper skin care.
cial support: 100% of this poster is sponsored by The Procter &.
Commer GambleCompany
J AM ACAD DERMATOL AB85