gaucher disease: bone imaging. dxa (dual-energy x-ray absorptiometry)

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Gaucher Disease: Bone Imaging

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Page 1: Gaucher Disease: Bone Imaging. DXA (Dual-Energy X-ray Absorptiometry)

Gaucher Disease: Bone Imaging

Page 2: Gaucher Disease: Bone Imaging. DXA (Dual-Energy X-ray Absorptiometry)

DXA (Dual-Energy X-ray Absorptiometry)

Page 3: Gaucher Disease: Bone Imaging. DXA (Dual-Energy X-ray Absorptiometry)

DXA Spine Image and Test Results

Page 4: Gaucher Disease: Bone Imaging. DXA (Dual-Energy X-ray Absorptiometry)

DXA Hip Image and Test Results

Page 5: Gaucher Disease: Bone Imaging. DXA (Dual-Energy X-ray Absorptiometry)

Absorptiometry

Page 6: Gaucher Disease: Bone Imaging. DXA (Dual-Energy X-ray Absorptiometry)

BMD ↓

BMD ↓

BMD ↓

DXA: Trabecular Bone Change

Page 7: Gaucher Disease: Bone Imaging. DXA (Dual-Energy X-ray Absorptiometry)

BMD ↓

BMD ↓

BMD ↓

DXA: Cortical Bone Change

Page 8: Gaucher Disease: Bone Imaging. DXA (Dual-Energy X-ray Absorptiometry)

1

2

MeasurementSlice

Computed Tomography

Page 9: Gaucher Disease: Bone Imaging. DXA (Dual-Energy X-ray Absorptiometry)

Whole-body CT Scan With Vertebra

Page 10: Gaucher Disease: Bone Imaging. DXA (Dual-Energy X-ray Absorptiometry)

Close-up of Vertebra

Page 11: Gaucher Disease: Bone Imaging. DXA (Dual-Energy X-ray Absorptiometry)

Forearm CT Scan

Page 12: Gaucher Disease: Bone Imaging. DXA (Dual-Energy X-ray Absorptiometry)

Image of Radius and Ulna

Page 13: Gaucher Disease: Bone Imaging. DXA (Dual-Energy X-ray Absorptiometry)

TBD ↓

TBD ↓

TBD ↔

Quantitative Computed Tomography (QCT): Trabecular Bone Change

Page 14: Gaucher Disease: Bone Imaging. DXA (Dual-Energy X-ray Absorptiometry)

CBD ↓

CBD ↔

CBD ↔

QCT: Cortical Bone Change

Page 15: Gaucher Disease: Bone Imaging. DXA (Dual-Energy X-ray Absorptiometry)

Possible Conditions for Bone Loss

Resorption ↑ Formation ↔

Resorption ↔

Formation ↓

Resorption ↑

Formation ↓

Negative Balance

Page 16: Gaucher Disease: Bone Imaging. DXA (Dual-Energy X-ray Absorptiometry)

Follow-up Measurements

1 2 3

Measurement

0.5

0.6

0.7

0.8

BM

D [

g/c

m2 ]

Page 17: Gaucher Disease: Bone Imaging. DXA (Dual-Energy X-ray Absorptiometry)

Significant Differences

1 2

Measurement Point

0.60

0.65

0.70

0.75

0.80

0.85

BM

D [

g/c

m2]

2.8 sd(p>95%)

sd