gastric ulcer
DESCRIPTION
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FATIMA AL-AWADH
Gastric Ulcer
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• THE STOMACH IS THE FIRST INTRA-ABDOMINAL PART OF
THE GASTROINTESTINAL TRACT.
• IT IS A MUSCULAR, HIGHLY VASCULAR BAG-SHAPED
ORGAN. • THE STOMACH LIES IN THE
LEFT UPPER QUADRANT OF THE ABDOMEN.
Introduction
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Objectives
Mention the anatomy and histology of the stomach.
Define and display the morphology of gastric ulcer.
Mention the risk factors & causes of gastric ulcer.
Explain the pathophysiology of gastric ulcer.
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Pylorus Pyloric canal
Anatomy of the stomach
FundusCardi
a
BodyPyloricantrum
ESOPHAGUS
Duodenum
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Histology of the stomach
Gastric pits
Gastric glands
Muscularis mucosa
Blood vesselsOblique muscle
layerCircular muscle layerLongitudinal muscle layerConnective tissue layerVisceral
peritunium
Mucosa
Sub-mucosa
Muscularis
Serosa
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Ulcers
An ulcer is a medical condition caused by a break in a bodily membrane.
Common forms of ulcers include:
Skin ulcer
Genital ulcer
Mouth ulcer
Peptic ulcer
Venous ulcer
Ulcerative
colitis
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Gastric ulcer
A break in the normal tissue that lines the stomach.
A type of peptic ulcers.
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Morphology
Gastric peptic ulcers are
predominantly located near the interface of the
body and antrum.
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Statistics per 100,000 inhabitant
no data less than 20 20-80 80-140 140-200 more than 200
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Risk Factors
Non-steroidal anti-inflammat-ory drugs
Helicobacter (H) Pylori infection
Smoking Increasing age
Alcohol abuse
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Pathophysiology
1 .Aggressive factor
H. PyloriNSAIDs; Aspirin Corticosteroi
ds
Alcohol abuse
Cigarette smoking
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Pathophysiology
2 .Increased gastric acidity
ClH K C
l
NaC
l
ClH
ClH K C
l
KCl
NaC
l
Na C
l
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The increasing acidity
Increase in the process pepsinogen→ pepsin rate
Activation
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Pathophysiology
3 .Impaired defensesDecrea
se in
Epithelial
transport
Mucosa secretio
n
HCO3¯ secreti
on
Blood flow
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Pathophysiology
4 .Gastric ulcerSome cells die
due to ↑ digestive enzymes and
↓ defense in the stomach.
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Pathophysiology
4. Gastric ulcer
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References
Clinically Ordinated Anatomy, 6th ed. Pg233,Figure2.37.B.
Anatomy of the stomach
http://www.britannica.com/EBchecked/media/68634/Structures-of-the-human-stomach-The-stomach-has-three-layers
Histology of the stomach
http://en.wikipedia.org/wiki/Ulcer Definition and types of ulcer
http://ak47boyz90.wordpress.com/2010/09/02/l5-patho-peptic-ulcer-disease/
Morphology
\http://www.umm.edu/patiented/articles/who_gets_peptic_ulcers_000019_5.htm
Risk factors
\http://www.histopathology-india.net/PepUlc.htm
Pathophysiology
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