Presented at Foot Health 2012, Kettering

The next generation treatment for Podiatry

Gary Beale

Emblation Limited

Presented at Foot Health 2012, Kettering

overview

microwave and heating

microwaves place in medicine today

current technology shortfalls and limitations

introduction of new technology

potential medical applications

the swift approach for Podiatry and Dermatology

Presented at Foot Health 2012, Kettering

what are microwaves?

ionising radiation non-ionising radiation

the electromagnetic spectrum

300MHz – 300GHz range

Presented at Foot Health 2012, Kettering

microwaves like water!!!

When electric field is applied, water dipole tries to align with field

low frequency (RF), easily aligns => no heating occurs (conduction only)

high frequency (laser) – field too quick - no dipole movement => no heating

in between (microwave) frequency – dipole tries to align but lags behind field

causing molecules to collide.

friction => internal heat generation!

how do microwaves heat?

Presented at Foot Health 2012, Kettering

Mostly operating theatre based procedures:

Acute and chronic conditions

Oncology (liver lung kidney breast)

Urology (BPH)

Gynaecology (menorrhagia)

expensive – both system and applicator

not portable

high maintenance

They are but in limited fields of medicine due to generator size!!

why are microwaves not used more readily?

Presented at Foot Health 2012, Kettering

innovation created opportunities

What differentiates the swift system from the current microwave medical devices?

Generator suitable for BOTH office and theatre

small – approximate size of A4 ream of paper

light (~4kg) and very portable

cost effective for end-users to purchase and operate

reliable – cheap to maintain!

Platform Technology

Presented at Foot Health 2012, Kettering

market identification

What are the markets suitable for swift microwave technology?

Oncology

Malignant neoplasms of skin

Malignant melanoma of skin

Gynaecology

Endometriosis

vaginal warts

Ear Nose Throat (ENT)

Acute tonsillitis, unspecified

Malignant neoplasm of tonsil

Podiatry & Dermatology

HPV - Common warts (cutaneous, hands, face)

HPV - Plantar warts (foot verrucas)

Nail - ingrown toenail; fungal nail

Presented at Foot Health 2012, Kettering

swift in Podiatry

No gold standard treatment

Low to moderate efficacy

Complications

Literature favours thermal ablation

Regulatory ease

Salicylic acid:

•slow, painful, ineffective

Liquid nitrogen cryotherapy:

• slow, painful, ineffective

• repeat treatments (4-5)

• only slightly better than placebo (44% efficacy)

• HPV can survive cryotherapy

Pulsed Dye Laser:

• less painful

• very expensive (limited usage)

• repeat treatments (3-4 with 81% efficacy)

RF:

• painful

• tissue damage

• recurrence (70% efficacy)

Presented at Foot Health 2012, Kettering

swift advantage

Energy Deposition

capable of treating whole wart without breaking skin surface

reduced cross-contamination

reduced scarring

superior deposition of energy

magnitude cheaper than pulsed laser – lower maintenance costs

no plume

minimal procedural risk - no return electrode pad

Energy Absorption

Presented at Foot Health 2012, Kettering

swift surface applicator

ergonomic

designed with minimal components

cheap to manufacture

affordable consumable product

ease of use

numerous medical applications

surface based ablation and coagulation

dermatology, podiatry, oncology etc…

Presented at Foot Health 2012, Kettering

swift surface applicator

fast and controllable – time dictates ablation size with accuracy ability to spot ablate or ablate along a path

Presented at Foot Health 2012, Kettering

swift preclinical study

Preclinical outcome:

Ability to carry out very short or long ablations

Repeatable and precise (very localised)

Predetermined cell death “with confidence”

Presented at Foot Health 2012, Kettering

why use swift??

energy modality suited for application

ease of use

repeatable procedure – reduce human error

compact and portable system to fit with typical clinic/ user requirements

small – approximate size of A4 ream of paper

platform technology - adaptable for new procedures e.g. nail

affordable disposable applicators

cost effective for end-users to purchase and operate

Presented at Foot Health 2012, Kettering

next stages

Corporate

CE Mark expected end of month

UK roll-out to follow

Clinical

capture clinical data for procedure approach

energy dosage versus condition

podiatry and dermatology applications

Technical

develop nail applicators

certify procedure (CE Mark)

Presented at Foot Health 2012, Kettering

thank you

www.treatwithswift.com