gabriel g. haddad, m.d. curriculum vitae personal home

GABRIEL G. HADDAD, M.D.

CURRICULUM VITAE

PERSONAL HOME ADDRESS P.O. Box 5000, PMB 162 Rancho Santa Fe, CA 92067 OFFICE ADDRESS University of California, San Diego Rady Children’s Hospital of San Diego Department of Pediatrics Office of the Chairman 115 Leichtag Building 9500 Gilman Drive, Mailcode 0735 San Diego, CA 92093-0735 Phone: 858-822-4740 Fax: 858-534-6972 E-mail: [email protected] MARITAL STATUS Married, three children

EDUCATION & TRAINING 1965 – 1969 B.S., Biology/Chemistry, American University of Beirut, Beirut, Lebanon 1969 – 1974 M.D., Intern & Jr. Resident, American University of Beirut, Beirut, Lebanon 1974 - 1975 Senior Resident in Pediatrics University of Texas Medical Center Houston, Texas 1975 - 1978 Fellow, Pediatric Pulmonary Division Columbia University, College of Physicians & Surgeons

CURRENT APPOINTMENTS

UNIVERSITY

Professor of Pediatrics and Neuroscience

University of California, San Diego School of Medicine Chairman, Department of Pediatrics

HOSPITAL

Physician-in-Chief and Chief Scientific Officer

Rady Children’s Hospital of San Diego

mailto:[email protected]

PROFESSIONAL EXPERIENCE 1978 - 1984 Columbia University, College of Physicians & Surgeons Assistant Professor of Pediatrics 1980 - 1988 Columbia University, College of Physicians & Surgeons Department of Pediatrics Director, Sleep Physiology Laboratory 1988 Columbia University, College of Physicians & Surgeons Associate Professor of Pediatrics 1988 - July 1990 Yale University School of Medicine Associate Professor of Pediatrics Director, Section of Respiratory Medicine Chief of Clinical Service, Respiratory Medicine July 1990 - July 2002 Yale University School of Medicine Professor of Pediatrics Director, Section of Respiratory Medicine Chief of Clinical Service, Respiratory Medicine July 1993 - July 2002 Yale University School of Medicine Professor of Cellular & Molecular Physiology (Joint Appointment) July 2002 – August 2005 Albert Einstein College of Medicine Professor of Pediatrics and Neuroscience University Chairman, Department of Pediatrics The Children’s Hospital at Montefiore Pediatrician-in-Chief August 2005 - University of California, San Diego School of Medicine Professor of Pediatrics& Neuroscience Chairman, Department of Pediatrics Rady Children’s Hospital of San Diego Physician-in-Chief

SABBATICALS July 1986 – June 1987 Sabbatical Year University of Iowa Department of Physiology & Biophysics Laboratory of Dr. Peter Getting Jan. 1996 – Dec. 1996 Sabbatical Year Yale University School of Medicine Boyer Center for Molecular Medicine Department of Genetics Laboratory of Tian Xu, Ph.D.

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BOARD CERTIFICATION 1980 American Board of Pediatrics License in the states of Connecticut, New York and California

AWARDS AND HONORS 1972 Alpha Omega Alpha Honor Medical Society 1976 - 1979 Parker B. Francis Fellowship Award The Francis Families Foundation 1977 - 1978 Milton Singer Fellow Columbia University College of Physician & Surgeons 1979 - 1982 Edward Livingston Trudeau Scholar Award American Lung Association 1985 - 1990 Established Investigator Award American Heart Association 1991 Pediatric Faculty Teaching Award Yale University School of Medicine 1992 Award for Excellence in Pediatric Research American Academy of Pediatrics 2001 Parker B. Francis Distinguished Alumnus Fellow of the Year The Francis Families Foundation 2002 Recognition for Scientific Accomplishments Award American Thoracic Society 2005 Julius H. Comroe Jr. Distinguished Lectureship International Union Physiological Sciences Meeting

2008 Elected to the Association of American Physicians 2009-2010 Elected to the 2009-2010 Best Doctors in America

PROFESSIONAL ACTIVITIES

TEACHING

Physiology Course

First Year Medical Students Yale University School of Medicine

Introduction to Medicine, Lung Module

Second Year Medical Students Yale University School of Medicine

Interdepartmental Neuroscience Program: Seminars for

Graduate Students

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Yale University School of Medicine

Teaching Rounds, Developmental Biology M.D./Ph.D. Students

Yale University School of Medicine

Teaching Chairman Rounds Pediatric Residents

Albert Einstein College of Medicine

MD/PhD and Genetics graduate student seminars Albert Einstein College of Medicine

Students Interested in Pediatrics

First-year Medical Students University of California, San Diego

Medical Scientists Training Program University of California, San Diego

Professors Rounds

University of California, San Diego Rady Children’s Hospital, San Diego

Oxygen Biology Group

Pediatric Postdoctoral Fellows, Students & Principal Investigators University of California, San Diego

Rady Children’s Hospital, San Diego

Fellow Research Conferences Pediatric Fellows

University of California, San Diego Rady Children’s Hospital, San Diego

Faculty Research Conferences

Pediatric Postdoctoral Fellows and Faculty University of California, San Diego

Rady Children’s Hospital, San Diego

Medical students/Pharmacy Students Genetics Course Organized the Genetics course this past year (2008-2009) Gave a number of talks as part of the course (2008-2009)

Genetics Course Director for Medical and Pharmacy Students (2009-2010)

EDITORIAL APPOINTMENTS 1983 -1995 Editorial Board, Journal of Applied Physiology 1989 - 1993 Associate Editor, Journal of Applied Physiology 1993 - 1998 Associate Editor, Pediatric Research

1999 - 2002 Consulting Editor, Journal of Applied Physiology

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COMMITTEES Academic: 1992 - 1994 Member, Yale University School of Medicine Committee on Priorities and

Planning/Tenure Allocation 1998 – 2001 Scholar Awards Committee, Yale University School of Medicine 1999 – 2002 Senior Appointments and Promotions Committee,

Yale University School of Medicine 2002 – 2005 Member, Committee of Professors (Promotions Committee) Albert Einstein College of Medicine 2002 – 2005 Member, Rank subcommittee, University Department of Pediatrics Albert Einstein College of Medicine 2002 – 2005 Member, Senate Council Albert Einstein College of Medicine 2005 – present Ex-Officio Member, Board of Trustees Rady Children’s Hospital, San Diego 2005 – present Member, Board of Directors Children’s Specialists of San Diego 2005 – present Member, President’s Council/Executive Team Rady Children’s Hospital, San Diego 2005 – present Member, Medical Executive Committee Rady Children’s Hospital, San Diego 2005 – present Member, Board of Trustees, Medical Affairs Committee Rady Children’s Hospital, San Diego 2005 – present Board of Governors/Clinical Strategies and Operations Committee University of California, San Diego 2005 – present Stem Cell Academic Working Group University of California, San Diego 2005 – present EngMed Initiative Executive Committee University of California, San Diego 2005 – present Board of Governors Committee University of California, San Diego 2008-present Institute of Engineering in Medicine Advisory Committee University of California, San Diego 2008-present Master of Advanced Studies (MAS) Advisory Committee University of California, San Diego

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2009-present The Institute for Genomic Medicine Advisory Committee University of California, San Diego 2010-present Health Sciences Faculty Development Committee University of California, San Diego School of Medicine National/International:

1982 - 1983 NICHD Study Section Embryology and Human Development 1983 NICHD Conference Future Research in SIDS 1984 NIH reviewer SBI Research 1985 & 1990 NIHLB site visitor Program Project, Cleveland 1987 NIHLB conference, Session Chairman Developmental Neurobiology of Breathing 1988 NIHLB conference Respiratory muscle fatigue 1988 NICHD conference, subcommittee chairman Future Research in SIDS 1988 - Present Respiratory Neurobiology & Sleep Section American Thoracic Society - Long Term Planning Committee - Secretary for Assembly (1991-1992) - Chair of Assembly (1995 - 1997)

1991 Session Chair, International Conference on Sleep and Cardiorespiratory Control,

Paris, France, September 1991.

1992 Member, Long Range Planning Committee, American Thoracic Society 1992 Session Co-Chairman and organizer: Brain hypoxia and the regulation of breathing.

American Thoracic Society Meeting, Miami, FL, May, 1992.

1992 NICHD, Consultant, Steering Committee, Review of apnea monitors, July, 1992.

1992 NIH ad hoc Study Section, Lung Biology and Pathology, July 1992.

1993 Chair, Session on Neurobiology. Society of Pediatric Research Meeting, Washington, DC, May, 1993.

1993 Session Co-Chair, “How the carotid body senses hypoxia”. American Thoracic

Society Meeting, San Francisco, CA, May, 1993. 1993 Chair, NIH ad hoc Study Section, Lung Biology and Pathology, December, 1993.

1994 - 1996 Vice President

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Pediatric Pulmonary Training Directors Association (PEPTDA) 1995 – 1997 Chairman, Section of Respiratory Neurobiology and Sleep, American Thoracic Society 1995 - 1997 American Thoracic Society Board of Directors 1996 Member, Revenue Development Committee,

American Lung Association 1996 - 2002 Clinical Research Advisory Committee

March of Dimes Birth Defects Foundation 1996 American Thoracic Society Leadership Retreat and Board of Directors Meeting,

Orlando, FL, February 28-31, 1996.

1997 - 1998 Planning Committee, American Thoracic Society 1997 “Neurocognitive function in children with obstructive sleep apnea”. Co-organizer, NIH-American Thoracic Society Workshop, Washington, D.C. March 17, 1997. 1998 Co-chair and organizer, Sponsored by the NIH-NHBLI and the American Thoracic

Society Workshop – “Molecular and Genomic Effects of Tissue Oxygen Deprivation in Sleep Apnea”. Also, Session Moderator – “Hypoxia and Neuronal Injury”. Rockville, MD, September 24-25, 1998.

2002 Session Chair, Winter Conference on Brain Research (WCBR). Snowmass, CO,

January 26-February 2, 2002. 2002 External Advisory Committee Member - Specialized Neuroscience Program,

Howard University College of Medicine. Washington, D.C., April 3-4, 2002. 2003 Nominating Committee for President of the American Thoracic Society, January,

2003 2003 ACGME (American Academy of Sleep Medicine) Ad Hoc Committee Member.

Chicago, Illinois, January 13, 2003. 2001 – 2006 External Advisory Committee Member - Specialized Neuroscience Program,

Howard University College of Medicine. Washington, D.C., March 26-27, 2003. 2004 – 2005 Member, American Thoracic Society Awards Committee 2006 - present Chairman, Data Safety and Monitoring Board for Sickle Cell Anemia, HLB

Institute, National Institute of Health Ph.D. ADVISOR/THESIS COMMITTEE MEMBER 1981 Thesis Committee Member for PhD thesis of I. Gopal. "Spectral analysis of RR

interval". Columbia University. 1986 Thesis Committee Member for PhD thesis of H.J. Jeng. "Statistical analysis of the

electromyogram". Columbia University.

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1988 Advisor for PhD thesis of Sharon Akabas. "Oxidative enzyme induction". Columbia University.

1993 Thesis Committee Member for PhD thesis of Charlotte Youngson. “Characterization

of the O2-sensing mechanism in pulmonary neuro-epithelial bodies and their role as hypoxia-sensitive airway chemoreceptors”. University of Toronto.

1996 Advisor for PhD thesis of Theodore Reichley Cummins. "Molecular Pathophysiology

of a mutant sodium channel". Yale University. 1997 Advisor for PhD thesis of John Patrick O'Reilly. "Hypoxia in the Central Nervous

System: Electrophysiologic Responses and the Role of Na+ channels". Yale University.

2000 Thesis Committee Member for PhD thesis of Lei Xu. Yale University. 2003 Advisor for PhD thesis of Vernon Ruffin. “The Gardos channel and responsiveness

to hypoxia in an oocyte system”. Howard University. 2006 - present PhD Advisor, DeeAnn Visk, Biology graduate student, UCSD 2006 - 2008 Thesis Committee Member for PhD of Jake Feala, UCSD 2008-present PhD Advisor, Erilynn Russo, Biomedical Sciences graduate student, UCSD 2008-present Thesis Committee Member for Daniel Popa, UCSD

INVITED SPEAKER/VISITING PROFESSORSHIPS / SELECTED NATIONAL PRESENTATIONS (1991 – PRESENT)

Visiting Professor, Karolinska Institute, Department of Pediatrics and Physiology, Sweden, September, 1991. Visiting Professor, University of Oklahoma, Department of Physiology and Program in Neurobiology, April, 1992. Visiting Professor, University of Colorado, Department of Pediatrics, Division of Pulmonary Medicine, May, 1992. Invited speaker and Session chair, Chair, Session on O2 sensing and chemoreceptors; Presented, “Role of Na+ current and transport during anoxia: Developmental aspects”. Wellcome Trust, England, October 16-21, 1992. Invited speaker, NIH-INSERM Meeting, "How neurons can survive O2 deprivation: ion channel mechanisms”. Nancy, France, September 7-9, 1992. Invited speaker, Winter Conference on Brain Research “ATP-sensitive K+ channels and brain anoxia”. Vancouver, British Columbia, January, 1993. Invited speaker, Experimental Biology Meeting. “Cardio-respiratory interactions during sleep in early life”. New Orleans, LA, March, 1993. “Developmental neuronal sensitivity to anoxia: Role of extra-cellular calcium and sodium”. Presented at the Society for Pediatric Research Meeting, Washington, DC, May, 1993. “Development and distribution of voltage-sensitive sodium channels in the rat CNS”. Presented at the Society for Pediatric Research Meeting, Washington, DC, May, 1993.

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Invited speaker, American Thoracic Society Meeting. “Cellular mechanisms of effect of hypoxia on hypoglossal motoneurons”. San Francisco, CA, May, 1993. Invited speaker, University of Toronto Research Institute. “Neuronal survival during O2 deprivation”. Toronto, Canada, May, 1993. “Hypoxia activates an ATP- and Ca++ -sensitive K+ channel in canthal neurons”. Presented at the XXXII Congress of the International Union of Physiological Sciences, Glasgow, Scotland, August, 1993. Invited speaker, Howard University. International Symposium on “Ventral brainstem mechanisms and control functions”. Washington, DC, November, 1993. “Effect of anoxia on intracellular pH in isolated newborn and mature rat hippocampal CA1 neurons”. Presented at the Society for Pediatric Research Meeting, Washington, DC, November, 1993. “Cloning of a glutamate transporter from human brain”. Presented at the Society for Neuroscience Meeting, Washington, DC, November, 1993. “Cloning of a novel human brain ion channel highly similar to KATP channel in rat kidney”. Presented at the Society for Neuroscience Meeting, Washington, DC, November, 1993. “Different responses of brainstem and cortical neurons to graded hypoxia”. Presented at the Society for Neuroscience Meeting, Washington, DC, November, 1993. “Anoxia induces an increase in intracellular sodium in primary neocortical neuronal cultures”. Presented at the Society for Neuroscience Meeting, Washington, DC, November, l993. Invited speaker, Twelfth Conference on Apnea of Infancy. “Control of respiration in early life: Molecular, Integrated and Practical Issues”. Annenberg Center at Eisenhower, Rancho Mirage, CA, January, 1994. Invited speaker, American Pediatric Society and the Society for Pediatric Research Meeting. “Respiratory and Pulmonary Adaptation to Birth”. Seattle, WA, May, 1994. Invited speaker, 29th Middle East Medical Assembly. “Overview of SIDS”. Beirut, Lebanon, May, 1994. Invited speaker, 29th Middle East Medical Assembly. Naji Sahyoun Memorial Lecture: “Brain hypoxia and neuronal survival strategies”. Beirut, Lebanon, May, 1994. “Anoxia increases intracellular sodium in neurons”. Presented at the American Thoracic Society Meeting, Boston, MA, May, 1994. “Brain hypoxia: Role and molecular characterization of ATP-sensitive potassium channels in neuronal membranes”. Presented at the American Thoracic Meeting, Boston, MA, May, 1994. “Is neonatal neuronal resistance to anoxia due to decreased glutamate sensitivity?” Presented at the American Thoracic Society Meeting, Boston, MA, May, 1994. “Increased neuronal sensitivity to acute hypoxia in rats after long-term exposure to a reduced oxygen environment”. Presented at the American Thoracic Society Meeting, Boston, MA, May, 1994. Invited speaker, 3rd International Symposium on Hypoxia. “Brain Hypoxia: Role and molecular characterization of ATP-sensitive potassium channels in neuronal membranes”. Berlin, September, 1994. “Adenosine activates a glilbenclamide-sensitive K+ current in postsynaptic neurons”. Presented at the Society for Neuroscience Meeting, Miami, FL, November, 1994.

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“Increased neuronal sensitivity to acute hypoxia in rats after long-term exposure to a reduced oxygen environment. Presented at the Society for Neuroscience Meeting, Miami, FL, November, 1994. “Anoxia causes cleavage and rearrangement of cytoskeletal proteins in rat cortical neurons”. Presented at the Society for Neuroscience Meeting, Miami, FL, November, 1994. “Neonatal CA1 neurons do not respond to glutamate concentrations that kill adult neurons: Time-lapse confocal studies in vitro. Presented at the Society for Neuroscience Meeting, Miami, FL, November, 1994. “Different responses of cortical and brainstem neurons to graded hypoxia”. Presented at the American Thoracic Society Meeting, Seattle, WA, May, 1995. “Drosophila melanogaster survive prolonged periods of anoxia”. Presented at the American Thoracic Society, Seattle, WA, May, 1995. American Thoracic Society Leadership Retreat and Board of Directors Meeting, Orlando, FL, February 28-31, 1996. Invited speaker, The Society for Gynecologic Investigation Symposium. “Do Na+ dependent exchanges play a role in anoxic injury in the mammalian CNS”. Philadelphia, PA, March 23, 1996. Invited participant, American Lung Association/American Thoracic Society, Respiratory, Neurobiology and Sleep Workshop, Bethesda, MD, May 3, 1996. American Thoracic Society Board of Directors Meeting, New York, New York, May 20-21, 1996. Invited speaker, ISN Forefront Symposium, Oxygen sensing on the cellular and molecular level. “Chemoreceptor Function”. Regensburg, Germany, June 22-29, 1996. Invited speaker, The American Physiological Society Conference on the Neural Control of Breathing: Molecular to Organismal Perspectives. “Hypoxic effects on the CNS neurons”. Madison, WI, July 21-25, 1996. Invited speaker, APS Intersociety Meeting, Integrative Biology of Exercise. “Nerve growth during development: Implications for exercise in children”. Vancouver, British Columbia, October 16-19, 1996. Invited speaker, Oxygen regulation of ion channels and gene expression workshop. “Ion channel function during hypoxia: Direct and indirect modulation”. Madrid, Spain November 24-26, 1996. “Effect on amiloride and its derivatives on the electrical properties of hippocampal CA1 neurons at rest and during anoxia”. Presented at the Society for Neuroscience Meeting, Washington, DC, November 16-21, 1996. Invited speaker, Oxygen Regulation International Meeting. “Ion channel function during hypoxia: Direct and indirect modulation”. Madrid, Spain, November 22-26, 1996. Co-organizer and speaker, NIH-American Thoracic Society Workshop. “Neurocognitive function in children with obstructive sleep apnea”. Washington, DC, March 17, 1997. “Genetic determination of anoxic tolerance in Drosophila melanogaster flies”. Presented at the Drosophila Research Conference, Chicago, IL, April, 1997. “Genetic determination of anoxic tolerance in Drosophila melanogaster flies”. Presented at the American Thoracic Society Meeting, San Francisco, Ca, May, 1997. Invited speaker, International Society on oxygen transport to tissue meeting (ISOTT). “Genetic basis for anoxia tolerance in Drosophila melanogaster". Milwaukee, WI, August 21, 1997.

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"Genetic basis for anoxia tolerance in Drosophila melanogaster. Presented at the Society for Neuroscience Meeting, New Orleans, LA, October 25-30, 1997. “Modulation of the sodium hydrogen exchanger: Effect of development and hypoxic stress. Presented at the Society for Neuroscience Meeting, New Orleans, LA, October 25-30, 1997. “Modulation of the calcium-activated potassium channels in excised patches by low oxygen”. Presented at the Society for Neuroscience Meeting, New Orleans, LA, October 25-30, 1997. Studies on anoxia tolerance and susceptibility. Presented at the Cellular and Molecular Physiology Department Retreat, Woods Hole, MA, November 14-16, 1997. Use of Drosophila melanogaster in anoxia tolerance. Presented at the Interdepartmental Neuroscience Program Retreat (INP), Woods Hole, MA, February, 1998. Invited speaker, University of Pennsylvania Medical Center, Center for Sleep and Respiratory Neurobiology. "Drosophila melanogaster: A model system to study nerve cell response to O2 deprivation”. Philadelphia, PA, February 27, 1998. “Genetic basis of hypoxia-anoxia tolerance in Drosophila melanogaster”. Presented at the Experimental Biology Meeting, San Francisco, CA, April 18-22, 1998. Invited speaker, Penn State College of Medicine. “Molecular basis for anoxia tolerance: Use of Drosophila as a model system”. Hershey, PA, May 7, 1998. Invited speaker, Membrane Transport Research Group Workshop. “O2 sensors”. Montreal, Canada, May 21-22, 1998. Invited participant, NIH - SIDS Pathogenesis – Approaches to Identifying High Risk Infants Working Group Meeting. Lake Arrowhead, Ca, September 13-16, 1998. Co-chair and organizer, sponsored by the NIH-NHLBI and the American Thoracic Society Workshop – “Molecular and Genomic Effects of Tissue Oxygen Deprivation in Sleep Apnea”. Session Moderator – “Hypoxia and Neuronal Injury”. Rockville, MD, September 24-25, 1998. Guest Lecturer, Research Update in Neurosciences for Neurosurgeons Course (RUNN). “Fruit fly genes and neuronal tolerance to hypoxia”. Woods Hole, MA, October 20-29, 1998. Invited participant, The RSV-Asthma Link: The Emerging Story Conference sponsored by the American Thoracic Society. Washington, D.C., November 6-7, 1998. “Cloning and genetic analysis of Drosophila melanogaster HIF1β homolog, a hypoxia-regulated transcription factor”. Presented at the Society for Neuroscience Meeting, Los Angeles, CA, November 7-12, 1998. “Developmental and stress-induced profile of two CNS pH regulatory proteins: The Na/H exchanger and the Na/HCO3 cotransporter”. Presented at the Society for Neuroscience Meeting, Los Angeles, CA, November 7-12, 1998. “Effects of hypoxia on embryonic Drosophila neurons in culture. Presented at the Society for Neuroscience Meeting, Los Angeles, CA, November 7-12, 1998. “pH regulation of CA1 neurons isolated from NHE-1 null mice”. Presented at the Society for Neuroscience Meeting, Los Angeles, CA, November 7-12, 1998.

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“Differential effects of chronic hypoxia on neuronal and astrocytic glutamate transporters in developing rat brains”. Presented at the Society for Neuroscience Meeting, Los Angeles, CA, November 7-12, 1998. Invited guest, Middle Eastern & Mediterranean Pediatric Society Meeting. “Asthma Pathogenesis”. American University of Beirut, Beirut, Lebanon, April 15-17, 1999. Invited guest, Middle Eastern & Mediterranean Pediatric Society Meeting. “Obstructive Sleep Apnea”. The American University of Beirut, Beirut, Lebanon, April 15-17, 1999. “A rat chronic hypoxia model: Differential responses of various organs to oxygen (O2) deprivation”. Presented at the ALA/ATS International Conference, Chicago, IL, April 24-29, 1999. “The effect of oxygen deprivation on the cell cycle of Drosophila melanogaster embryos”. Presented at the Pediatric Academic Societies’ Annual Meeting (APS/SPR), San Francisco, CA, May 1-4, 1999. “Tolerance to O2 deprivation: Genetic basis using a Drosophila model system”. Presented at the Pediatric Academic Societies’ Annual Meeting (APS/SPR), San Francisco, CA, May 1-4, 1999. Invited speaker, Cardeza Foundation for Hematologic Research and Division of Hematology, Jefferson Medical College, Thomas Jefferson University, Research Seminar. “Tolerance to lack of O2: A model approach in the fruit fly”. Philadelphia, PA, May 12, 1999. Invited participant, Oxygen Sensing: Molecule to Man Symposium, University of Pennsylvania Medical Center. “Oxygen deprivation of rat hippocampal neurons”. Philadelphia, PA, June 24-28, 1999. Session Chair, Ion Channel Structures & Function Conference. Yale University School of Medicine, Department of Pediatrics and Boyer Center for Molecular Medicine, July 16-18, 1999. Member, Site Visit Team, National Institutes of Health, National Center for Research Resources, Bethesda, MD. Review Application for a General Clinical Research Center (GCRC). University of Virginia, Charlotttesville, Virginia, July 21-22, 1999. Invited lecturer, Research Update in Neuroscience for Neurosurgeons (RUNN) Course. “Neuronal response to lack of oxygen”. Marine Biology Laboratory, Woods Hole, MA, October 9-17, 1999. Invited Speaker, Veterans Memorial Medical Center, Department of Neurology. “Drosophila melanogaster as a animal model to study anoxia tolerance”. West Haven, CT, March 1, 2000. Visiting Professor/Invited speaker, Shanghai Medical University. "NHE in anoxia"; "Na+, K+ channels and their role in anoxia"; "Tolerance of Drosophila melanogaster to anoxia"; "RNA editase and its role in anoxia", Shanghai, China, June 22 - 30, 2000. Invited speaker, Research Update in Neuroscience for Neurosurgeons (RUNN) Course, "Fly Genes and Resistance to Hypoxia". Marine Biology Laboratory, Woods Hole, MA, October 16, 2000. Invited participant, NHLBI RFA Investigator Coordination Meeting, "Oxygen Sensing During Intermittent Hypoxia". National Institutes of Health, Bethesda, MD, January 22, 2001. Invited speaker, Case Western Reserve University - Rainbow Babies & Children's Hospital. Neonatal Physiology Course - "Molecular and cellular basis for neuronal responses to hypoxia". Pediatric Research Conference - "Genes that protect against hypoxic injury: Use of genetic model systems". Cleveland, OH, January 25 - 26, 2001. Invited reviewer, University of Pennsylvania, Center for Sleep and Respiratory Neurobiology, External Review. Philadelphia, PA, January 30-31, 2001.

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Invited speaker, St Luke's Hospital of Kansas City - "Tissue hypoxia and mechanisms of Cellular Injury". Kansas City, MO, May 18, 2001. Invited participant, NHLBI RFA Investigator Coordination Meeting, "Oxygen Sensing During Intermittent Hypoxia". National Institutes of Health, Bethesda, MD, February 11, 2002. Invited speaker, Howard University, Department of Physiology and Biophysics. “Understanding mammalian cellular response to hypoxia using Drosophila as a genetic model”. Washington, D.C., February 12, 2002. Invited speaker, Neuroscience Program Retreat. “Understanding oxygen sensing and response to O2 deprivation using a genetic model”. Marine Biology Laboratory, Woods Hole, MA, February 15-17, 2002. Invited Professor session moderator, Eastern Society for Pediatric Research. “Preparing for a Career as a Pediatrician-Scientist”. Hyatt Regency Hotel, Greenwich, CT, March 9, 2002. Invited speaker, Ion Channels and Hypoxia Symposium. “Effect of hypoxia on neuronal sodium channels”. Experimental Biology 2002, New Orleans, LA, April 20-24, 2002. Invited speaker, American Thoracic Society International Conference. “Understanding mammalian cellular responses to hypoxia using Drosophila as a genetic model”. Atlanta, GA, May 17-22, 2002. Invited speaker, Sleep & Breathing Symposium. Session – Adaptation to Altitude: Brain Hypoxia and Gene Response. Reykjavik, Iceland, May 31-June 2, 2002. Invited speaker, International Union of Pharmacology (IUPHAR) Congress of Pharmacology. “Oxygen-sensitive channels in the CNS”. San Francisco, CA, July 7-12, 2002. Invited speaker, International Congress of Pathophysiology. “Drosophila Melanogaster: A genetic model for studying anoxia tolerance”. Budapest, Hungary, July 3-10, 2002. Ad Hoc Committee Member, ACGME American Academy of Sleep Medicine Meeting. Chicago, Illinois, January 13, 2003. Invited speaker, National Institutes of Health (NIH/NICHD). “Tissue hypoxia and cell injury: old questions but some new answers”. Bethesda, MD, January 30, 2003. External Advisory Committee Member, Specialized Neuroscience Meeting. Howard University, Washington, DC, March 26 - 27, 2003. Advisory Board Member, COBRE Grant External Advisory Board Meeting. University of Louisville, Louisville, KY, June 24 – 25, 2003. Invited speaker, Journal of Experimental Biology Symposium- Defenses against Brain Hypoxia: Molecule to Organism. “Drosophila: Genetic model of neuronal hypoxia tolerance”. Tuscany, Italy, September 13-17, 2003. Invited speaker, Sickle Cell Disease Advisory Committee. National Institutes of Health (NIH/NHLBI). “Sleep disturbances and hypoxemia in the pediatric population”. Bethesda, MD, November 3, 2003. Invited speaker, Grand Rounds, Bronx-Lebanon Hospital Center. “Pediatric Asthma – Challenges and Advances”. Bronx, New York, April 13, 2004. Invited speaker, Grand Rounds, New York University School of Medicine. “Lessons from flies: Understanding mammalian responses to hypoxia”. New York, NY, June 2, 2004. Invited speaker, University of Iowa. “Tissue (brain) hypoxia and cell injury: Some insights from invertebrates”. Iowa City, IA, June 22, 2004.

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Invited speaker, SIDS International Conference. “Mechanisms of hypoxia cell death or tolerance: insights from genetic models”. Edmonton, Alberta, Canada, July 2-6, 2004. Invited speaker, XXII International Congress of Entomology. “Genetic mechanisms underlying anoxia tolerance in insects”. Brisbane, Australia, August 15-21, 2004. Distinguished APS Julius Comroe Speaker, Experimental Biology Meeting. “Tolerance to low O2: Lessons from invertebrate genetic models.” San Francisco, CA, April 1-5, 2005. Invited speaker, Pediatric Grand Rounds. “Hypoxic Brain Injury.” UCSD, La Jolla, CA, November 4, 2005. Invited Moderator/Organizer, 47th Annual Drosophila Research Conference. “Gas sensing and responses in Drosophila.” Houston, Texas, April 1, 2006. Chairman, NIH/NHLBI DSMB Meeting. “Pulmonary Complications of Sickle Cell Disease DSMB”. National Institutes of Health, Bethesda, MD, January 12, 2006. Invited speaker, J. Christian Gillin Sleep Seminar. "Sleep, intermittent hypoxia, and CNS injury." UCSD, La Jolla, CA, June 6, 2006. Invited speaker, Inflammation, Degeneration and Regeneration from Basic Mechanisms to Clinical Manifestations International Symposium. “Hypoxic neuronal injury: insights from vertebrate and invertebrate models.” Magdeburg, Germany, November 30, 2006. Invited speaker, Pulmonary, Critical Care and Sleep Medicine Grand Rounds at University Hospitals Case Medical Center. “Hypoxia: From flies, to mammals, and humans.” Case Western Reserve University, Cleveland, OH, February 16, 2007. Invited speaker, Department of Physiology. “Genetic basis for Hypoxia tolerance for susceptibility: insights using invertebrates.” UCSD, La Jolla, CA, February 23, 2007. Invited speaker, Hypoxia Conference. “Selection for hypoxia tolerance in Drosophila.” Lake Louise, Canada, February 28, 2007. Invited speaker, 5th Lung Science Conference. “HIF-independent hypoxia induced gene regulation and protein modification.” Taormina, Italy, March 23, 2007. Invited speaker, Biomedical & Clinical Research Center Seminar. “Hypoxic cell injury: insights from vertebrates and invertebrates” UCSD, La Jolla, CA, April 4, 2007. Invited speaker, Basic Science Lecture. “Insights from Drosophila: Hypoxia-sensing and cell injury.” LAC Harbor – UCLA Medical Center, UCLA School of Medicine, Los Angeles, CA, April 10, 2007. Invited speaker, Department of Surgery Grand Rounds. “Hypoxic tissue injury: insights from vertebrates and invertebrates.” UCSD, La Jolla, CA, April 11, 2007. Invited speaker, Experimental Biology 2007, Respiratory Control in Insects: Integration from the Gene to the Organism. “Genetic basis for hypoxia tolerance in Drosophila melanogaster.” Washington, DC, April 29, 2007. Invited speaker, Medical Grand Rounds, "Hypoxia and CNS injury: newer insights from vertebrates and invertebrates". UCSD, La Jolla, CA, May 2, 2007. Invited speaker, Residents/Intern Seminar, “Cilia and Primary Ciliary Dyskinesia.” UCSD, La Jolla, CA, September 6, 2007.

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Invited speaker, Burnham Institute for Medical Research, “Flying high at low O2 with Drosophila.” September 20, 2007. Invited speaker, “Hypoxia Tolerance: Insights from Drosophila melanogaster”, Loma Linda University, Loma Linda, CA, February 14, 2008. Invited speaker, Physiology Seminar. “Hypoxic Cell Injury: Insights from Invertebrate Models." Emory University, Atlanta, GA, April 10, 2008. Invited speaker, American Thoracic Society Annual Meeting. “Hypoxia Effects on the Developing Brain." Toronto, Ontario, Canada, May 16, 2008. Invited speaker, American Thoracic Society Annual Meeting. “An Evolutionary Approach to Hypoxic Adaptation." Toronto, Ontario, Canada, May 18, 2008. Invited speaker, Southern California Drosophila Conference, “Tolerance to alterations in environmental oxygen in Drosophila melanogaster”, University of California, Irvine, Irvine, CA, September 5, 2008. Invited speaker and Conference Organizer, New York Academy of Sciences Conference, Hypoxia and Consequences: From Molecule to Malady, “Insights from an Invertebrate Model: Role of Specific Genetic Pathways in Survival to Extreme Hypoxia”, New York, NY, March 12, 2009. Invited speaker, Southern California Stem Cell Consortium, San Diego, CA, April 9, 2009. Invited speaker, American Thoracic Society Annual Meeting, “Hypoxia and Hypercapnia in Sleep: The Good and the Bad”, San Diego, CA, May 18, 2009. Invited speaker, PRISM (Progress in the Science of Medicine) Lecture Series, UCSD, La Jolla, CA, October 9, 2009. Invited Keynote speaker at ISOTT, Cleveland Ohio, July 6-8, “Flying high with flies: Insights from a genetic model system”, July 6, 2009. Invited speaker 2010 Keystone Symposium on Hypoxia: Molecular Mechanisms of Oxygen Sensing and Response Pathways, Jan 19 - Jan 24, 2010, Keystone, CO.

EXTERNAL REVIEWER

American Journal of Physiology Regulatory, Integrative and Comparative Physiology

Lung Cellular and Molecular Physiology Cell Physiology

American Journal of Respiratory and Critical Care Medicine Brain Research, Molecular Brain Research Comparative Biochemistry and Physiology Cortex Diabetes European Journal of Neuroscience European Journal of Physiology FASEB Journal Journal of Applied Physiology Journal of Clinical Investigation Journal of Membrane Biology Journal of Neurochemistry Journal of Neurophysiology

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Journal of Neuroscience Journal of Physiology Neuropharmacology Neuroscience Neuroscience Letters Open Journal of Neuroscience Pediatric Pulmonology Pediatric Research Physiologic Genomics Proceedings of the National Academy of Sciences Trends in Neuroscience PLoS Genetics PLoS One

ASSOCIATIONS AND SOCIETIES (Member since): 1978 American Thoracic Society 1980 American Physiological Society 1982 Society for Pediatric Research 1983 American Association for the Advancement of Science 1985 Society for Neuroscience 1985 American Heart Association 1991 Biophysical Society 1991 New York Academy of Sciences 1993 American Pediatric Society 1995 Society for General Physiologists 1996 Pediatric Pulmonary Training Directors Association 1997 The American Society for Cell Biology

1997 The Genetics Society of America 2003 Fellow, New York Academy of Medicine 2004 American Society of Cell and Molecular Biology

2006 Association of Medical School Pediatric Departments 2007 American Academy of Pediatrics 2008 Association of American Physicians

GRANT SUPPORT -Active

Ongoing Research Support 5 P01 HD 32573 (PI, Haddad) 12/01/96–07/31/10 NIH Total support: $6,441,769 Hypoxia in development: Injury and adaptation mechanisms The major goals of Project 1 are focused on voltage-sensitive Na+ channels and excitability in hypoxia. This project will investigate the electrophysiologic response to hypoxia in rat cortical neurons. Core A will provide administrative support and it will facilitate intellectual interactions. 1 R01 NS 37756 (PI, Haddad) 01/01/2000–04/30/10 NIH Total Support: $1,475,404 Molecular Basis of Cell Tolerance to O2 Deprivation The major goals of this grant are to identify, map and clone the genes that seem to be responsible and critical for recovery to O2 deprivation in Drosophila melanogaster using a genetic mutagenesis screen and ascertain the role of these genes at cellular and whole fly levels using several assays (e.g. ectopic expression, cell function under

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various conditions etc.). 1R21HL093611 (PI, Haddad) 4/1/09-3/31/11 NIH Total Support: $275,000 Resistance to oxidant injury In this proposal, we are studying the reasons why flies that have been selected experimentally over many generations resist very high O2 levels. Since the majority of disease genes in humans are present in flies, studying flies and the mechanisms that operate in these organisms becomes important and useful. Indeed, in the past we have been able to use fly genes to make human cells more resistant to certain stresses.

Pending Research Support 1P01HL098053 (Haddad P.I.) NIH/NHLBI (Haddad) 07/01/10-06/30/15 Molecular mechanisms of hypoxia tolerance and susceptibility Role on Projects: Program Project – P.I. Project 1 – P.I. Core A – P.I. Core C – Co-Inv This PPG is dedicated to the understanding of how tissues die or survive when animal or human tissues are deprived of oxygen. This is basic for many disease states such as obstructive sleep apnea, and cardio-respiratory diseases (e.g., Asthma and Sickle cell disease as well as COPD). We employ two animal models, one being susceptible and the other tolerant to low O2 to understand the differences and be able to render mammalian tissues that are sensitive to low O2 much more resistant to it. 1R01GM089897 (Haddad P.I.) 7/1/10-6/30/15 NIH Total Support: $1,250,000 Genetic Dissection of Hypoxia Tolerance This application addresses questions that will lead to our basic understanding of how flies, which are tolerant to low O2, manage to escape from cell and tissue damage when they are exposed to low O2. Furthermore, when we develop a framework for our understanding of tolerance and learning from flies, we will engineer cells or tissues from mammals that will be much more tolerant to low O2.

(Completed Research Support of the previous 3 years) 5 P01 HD 32573 (PI, Haddad) 02/10/95 - 11/30/04 NIH/ NICHD Total support: $3,696,500 Program Project - Hypoxia in development: Injury and adaptation mechanisms Project 1 - Na+ channels & excitability in hypoxia The major goals of Project 1 are focused on voltage-sensitive Na+ channels and excitability in hypoxia. This project will investigate the electrophysiologic response to hypoxia in rat cortical neurons. Core A will provide administrative support and it will facilitate intellectual interactions. 1 R01 HL 66327 (PI, Haddad) 09/30/00 - 08/31/04 NIH/ NHLBI Total Support: $700,000 Cyclical Hypoxia: Susceptibility to neuronal injury The goals of this project are to study cyclical hypoxia and determine the cellular and molecular mechanisms that can lead to cell injury (or adaptation and survival). In order to be consistent, and because cortical neurons have been shown to be vulnerable to hypoxic exposure, this work will be focused on the neocortex.

1 R01 NS 37756 (PI, Haddad) 01/01/00 – 12/31/04

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NIH/NINDS Molecular Basis of Cell Tolerance to O2 Deprivation The major goals of this grant are to identify, map and clone the genes that seem to be responsible and critical for recovery to O2 deprivation in Drosophila melanogaster using a genetic mutagenesis screen and ascertain the role of these genes at cellular and whole fly levels using several assays. 1 P01 NS42202 (PI, Kaczmarek, PI Haddad on Project 4) 07/01/01 – 06/30/06 NIH Total Support: $4,886,610 Hypoxia induces inhibition of BK(Ca) channel: Role and Mechanisms The major goals of this project are to study BK(Ca) channels and understand how they sense O2 lack and the role they play in hypoxic responses in both brainstem and neocortical neurons in mice and humans. 2 R01 HD34852 (PI, Xia) 04/01/02 - 03/31/07 NIH Total Support: $1,125,000 Hypoxia & Neuronal excitability: Cellular mechanisms The major goals of this project are to investigate the modulation of neuronal excitability and Na+ channel expression and the mechanisms by which Na+ channels are up regulated during chronic hypoxia. Role: Collaborator

BIBLIOGRAPHY

Original Published Articles

1. Haddad GG, Hajjar E, and Abufaisal K. Hyperosmolar, hyperglycemic, non-ketotic coma. Lebanese Med J, 26: 277-286, 1973.

2. Sanjad SA, Haddad GG, and Nassar VH. Nephropathy an underestimated complication of methicillin therapy. J

Pediatr, 84: 873-877, 1974. 3. Haddad GG and Mellins RB. The role of airway receptors in the control of respiration in infants. A review. J

Pediatr, 91: 281-286, 1977. 4. Haddad GG, Mazza NM, Defendini RF, Blanc WA, Driscoll JM, Epstein MA, Epstein RA and Mellins RB.

Congenital failure of automatic control of ventilation, gastrointestinal motility and heart rate. Medicine 57: 517-526, 1978.

5. Haddad GG, Krongrad E, Law HS, Mazza NM, Epstein MAF, Katz JB, Epstein RA, and Mellins RB. Effect of

sleep state on QT intervals in normal infants. Pediatr Res, 13: 139-141, 1979. 6. Haddad GG, Epstein MAF, Epstein RA, Mazza NM, Mellins RB, and Krongrad E. The QT interval in aborted

SIDS infants. Pediatr Res, 13: 136-138, 1979. 7. Haddad GG, Epstein RA, Epstein MAF, Leistner HL, Marino PA, and Mellins RB. Maturation of ventilation and

ventilatory pattern in normal sleeping infants. J Appl Physiol, 46: 998-1002, 1979. 8. Mazza NM, Epstein MAF, Haddad GG, Law HS, Mellins RB, and Epstein RA. Relation of beat to beat variability

to heart rate in normal sleeping infants. Pediatr Res, 14: 232-235, 1980. 9. Haddad GG, Epstein RA, Epstein MAF, Leistner HL, and Mellins RB. The R-R interval and R-R variability in

normal infants during sleep. Pediatr Res, 14: 809-811, 1980. 10. Leistner HL, Haddad GG, Epstein RA, Lai TL, Epstein MAF, and Mellins RB. Heart rate and heart rate

variability in aborted SIDS infants. J Pediatr, 97: 51-55, 1980. 11. Haddad GG, Leistner HL, Epstein RA, Epstein MAF, Grodin WK, and Mellins RB. C02-induced changes in

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ventilation and ventilatory pattern in normal sleeping infants. J Appl Physiol, 48: 684-688, 1980. 12. Epstein, RA, Epstein MAF, Haddad GG, and Mellins RB: Practical implementation of the barometric method for

measurement of tidal volume. J Appl Physiol, 49: 1107-1115, 1980. 13. Haddad GG, Walsh EM, Leistner HL, Grodin WK, and Mellins RB. Abnormal maturation of sleep of states in

infants with aborted Sudden Infant Death Syndrome. Pediatr Res, 15: 1055-1057, 1981. 14. Haddad GG, Leistner HL, Lai TL, and Mellins RB. Ventilation and ventilatory pattern during sleep in aborted

SIDS infants. Pediatr Res, 15: 879-883, 1981. 15. Gopal IS and Haddad GG. Automatic detection of eye movements in REM sleep using the electroculogram. Am J

Physiol, 241: R217-R221, 1981. 16. Haddad GG, Gandhi MR, and Mellins RB. Maturation of the ventilatory response to hypoxia in puppies during

sleep. J Appl Physiol, 52: 309-314, 1982. 17. Haddad GG, Lai TL, Epstein MAF, Epstein RA, Leistner HL, and Mellins RB. Breath to breath variations of rate

and depth of ventilation in normal sleeping infants. Am J Physiol, 243: R164-R169, 1982. 18. Haddad GG, Lai TL, and Mellins RB. Determination of the ventilatory pattern in REM sleep in normal infants. J

Appl Physiol, 53(1): 52-56, 1982. 19. Martin E, Bazzy AR, Gandhi MR, and Haddad GG. An investigation in the venous drainage of the diaphragm of

the sheep. Invest Radiol, 18: 272-274, 1983. 20. Leistner HL, Haddad GG, Lai TL, and Mellins RB. Heart rate pattern during sleep in an infant with congenital

prolongation of the QT interval (Romano-Ward syndrome). Chest, 84: 191-194, 1983. 21. Haddad GG, Gandhi MR, Hochwald G, and Lai TL. Enkephalin induced changes in ventilation and ventilatory

pattern in unanesthetized adult dogs. J Appl Physiol, 55: 1311-1320, 1983. 22. Bazzy AR, Haddad GG, Chang SL, and Mellins RB. Respiratory pauses during sleep in near-miss Sudden Infant

Death Syndrome. Am Rev Respir Dis, 128: 973-976, 1983. 23. Haddad GG, Bazzy AR, Chang SL, and Mellins RB. Heart rate pattern during respiratory pauses in normal

infants during sleep. J Dev Physiol, 6: 329-337, 1984. 24. Haddad GG, Jeng HJ, Lee SH, and Lai Tl. Rhythmic variations in the R-R interval during sleep and wakefulness

in puppies and dogs. Am J Physiol, 247 (Heart & Circ): H67-H73, 1984. 25. Bazzy AR and Haddad GG. Diaphragmatic fatigue in the unanesthetized adult sheep. J Appl Physiol, 57: 182-

190, 1984. 26. Haddad GG, Schaeffer JI, and KJ Chang. Opposite effects of the delta- and mu- opioid receptor agonists on

ventilation in conscious adult dogs. Brain Res, 323: 73-82, 1984. 27. Sadoul N, Bazzy AR, Akabas SR, and Haddad GG. Ventilatory response to fatiguing and non-fatiguing resistive

loads in awake sheep. J Appl Physiol, 59(3): 969-978, 1985. 28. Schaeffer JI and Haddad GG. Regulation of ventilation and oxygen consumption by delta- and mu- opiod

receptor agonists. J Appl Physiol, 59(3): 959-968, 1985. 29. Haddad GG, Jeng HG, and Lai TL. Effect of endorphins on heart rate, and blood pressure in adult dogs. Am J

Physiol, 250: H796-H805, 1986.

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30. Bazzy AR, Korten JB, and Haddad GG. Increase in electromyogram low-frequency power in non-fatigued contracting skeletal muscle. J Appl Physiol, 61 (3): 1012-1017, 1986.

31. Donnelly DF and Haddad GG. Respiratory changes induced by prolonged laryngeal stimulation in awake

piglets. J Appl Physiol, 61: 1018-1024, 1986. 32. Haddad GG, Jeng HJ, Bazzy AR, and Lai TL. Within breath electromyographic changes during loaded breathing

in adult sheep. J Appl Physiol, 61: 1316-1321, 1986. 33. Donnelly DF and Haddad GG. Effect of graded anesthesia on laryngeal-induced central apnea. Respir Physiol,

66: 235-245, 1986. 34. Haddad GG and Lasala PA. Effect of parasympathetic blockade on ventilatory and cardiac depression induced

by opioids. Respir Physiol 67: 101-114, 1987. 35. Haddad GG, Jeng HJ, Lai TL, and Mellins RB. Determination of sleep state in infants using respiratory

variability. Pediatr Res, 21 (6): 556-562, 1987. 36. Haddad GG, Jeng HJ, and Lai Tl. Heart rate variability during respiratory pauses in puppies and dogs. Pediatr

Res, 22(3): 306-311, 1987. 37. Moessinger AC, Singh M, Donnelly DF, Haddad GG, Collins MJ, and James LS. The effect of prolonged

oligohydramnios on fetal lung development, maturation and ventilatory pattern in newborn guinea pigs. J Dev Physiol, 9: 419-427, 1987.

38. Bazzy AR, Akabas SR, and Haddad GG. Respiratory muscle response to load and glycogen content in type I and

II fibers. Exp Neurol, 101: 17-28, 1988. 39. Sanocka UM, Donnelly DF, and Haddad GG. Cardiovascular and neurophysiologic changes during graded

duration of apnea in piglets. Pediatr Res, 23: 402-407, 1988. 40. Schaeffer JI and Haddad GG. Ventilatory response to moderate and severe hypoxia in adult dogs: role of

endorphins. J Appl Physiol, 65: 1383-1388, 1988. 41. Akabas SR, Bazzy AR, DiMauro S, and Haddad GG. Metabolic and functional adaptation of the diaphragm to

training with resistive loads. J Appl Physiol, 66: 529-535, 1989. 42. Rosen CL, Cote A, and Haddad GG. Effect of enkephalins on cardiac output and regional blood flow

distribution in the conscious dog. Am J Physiol, 256: H1651-H1658, 1989. 43. Bazzy AR, Pang LM, AKabas SR, and Haddad GG. O2 metabolism of the sheep diaphragm during flow resistive

loaded breathing. J Appl Physiol, 66: 2305-2311, 1989. 44. Singh M, Rosen CL, Chang KJ, and Haddad GG. Plasma B-casomorphin-7 immunoreactive peptide increases

after milk intake in newborn but not in adult dogs. Pediatr Res, 26: 34-38, 1989. 45. Korten JB and Haddad GG. Respiratory Waveform Pattern Recognition Using Digital Techniques. Comput

Biol Med, 19 (4): 207-217, 1989. 46. Haddad GG and Getting PA. Repetitive firing properties of neurons in the ventral region of the nucleus tractus

solitarius. In-vitro studies in adult and neonatal rat. J Neurophysiol, 62: 1213-1224, 1989. 47. Donnelly DF and Haddad GG. Prolonged apnea and impaired survival in piglets after sinus and aortic nerve

section. J Appl Physiol, 68(3): 1048-1052, 1990. 48. Cote A and Haddad GG. Effect of sleep on regional blood flow distribution in piglets. Pediatr Res, 28: 218-222,

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49. Haddad GG and Donnelly DF. O2 Deprivation induces a major depolarization in brainstem neurons in the adult

but not in the neonatal rat. J Physiol (London), 429: 411-428, 1990. 50. Haddad GG, Donnelly DF, and Getting PA. Biophysical properties of hypoglossal neurons in-itro: intracellular

studies in adult and neonatal rats. J Appl Physiol, 69: 1509-1517, 1990. 51. Xia Y and Haddad GG. Ontogeny and distribution of opioid receptors in the rat brainstem. Brain Res, 549:

181-193, 1991. 52. Jiang C and Haddad GG. The effect of anoxia on intracellular and extracellular potassium activity in

hypoglossal neurons in-vitro. J Neurophysiol, 66: 103-111, 1991. 53. Feldman JD, Bazzy AR, Cummins TR, and Haddad GG. Developmental changes in neuromuscular transmission

in the rat diaphragm. J Appl Physiol, 71(1): 280-296, 1991. 54. Cummins TR, Donnelly DF, and Haddad GG. Effect of metabolic inhibition on the excitability of isolated

hippocampal CA1 neurons: Developmental aspects. J Neurophysiol, 66: 1471-1482, 1991. 55. Xia Y and Haddad GG. Major differences in CNS sulfonylurea receptor distribution between the rat (newborn,

adult) and turtle. J Comp Neurol, 314: 278-289, 1991. 56. Jiang C, Agulian S, and Haddad GG. O2 tension in adult and neonatal brain slices under several experimental

conditions. Brain Res, 568: 159-164, 1991. 57. Jiang C, Xia Y, and Haddad GG. Role of ATP sensitive K+ channels during anoxia: Major differences between

rat (newborn, adult) and turtle neurons. J Physiol (London), 448: 599-612, 1992. 58. Jiang C, Agulian S, and Haddad GG. Cl- and Na+ homeostasis during anoxia in hypoglossal neurons:

intracellular and extracellular in-vitro studies. J Physiol (London), 448: 697-708, 1992. 59. Xia Y, Jiang C, and Haddad GG. Oxidative and glycolytic pathways in rat (newborn, adult) and turtle brain:

Role during anoxia. Am J Physiol, 262: R595-603, 1992. 60. Donnelly DF, Jiang C, and Haddad GG. Comparative responses of brainstem and hippocampal neurons to O2

deprivation: in vitro intracellular studies. Am J Physiol, 262: L549-554, 1992. 61. Sanocka UM, Donnelly DF, and Haddad GG. Auto-Resuscitation: A survival mechanism in piglets. J Appl

Physiol, 73: 749-753, 1992. 62. Xia Y and Haddad GG. Ontogeny and distribution of GABAA receptors in rat brainstem and rostral brain

regions. Neuroscience, 49(4): 973-989, 1992. 63. Rosen CL, D'Andrea L, and Haddad GG. Adult criteria for obstructive sleep apnea do not identify children with

serious obstruction. Am Rev Respir Dis, 146: 1231-1234, 1992. 64. Jiang C and Haddad GG. Differential responses of neocortical neurons to glucose and/or O2 deprivation in the

human and rat. J Neurophysiol, 68(6): 2165-2173, 1992. 65. Friedman JE and Haddad GG. Major differences in Ca2+

i between neonatal and adult rat CA1 neurons in response to anoxia: Role of Cao2+ and Nao

+. J Neurosci, 13(1): 63-72, 1993. 66. Rosen CL, Schecter WS, Mellins RB, and Haddad GG. Effect of Acute Hypoxia On Metabolism And Ventilation

In Awake Piglets. Respir Physiol, 91: 307-319, 1993.

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67. Marks JD, Donnelly DF, and Haddad GG. Adenosine-induced inhibition of vagal motoneuron excitability: receptor subtype and mechanisms. Am J Physiol, 264(8): L124-L132, 1993.

68. Cummins TR, Jiang C, and Haddad GG. Human neocortical excitability is decreased during anoxia via sodium

channel modulation. J Clin Invest, 91: 608-615, 1993. 69. Cummins TR, Agulian SK, and Haddad GG. Oxygen tension clamp around single neurons in-vitro: A

computerized method for studies on O2 deprivation. J Neurosci Methods, 46: 183-189, 1993. 70. Pincus SM, Cummins TR, and Haddad GG. Heart rate control in normal and aborted-SIDS infants. Am J

Physiol, 264(33): R638-R646, 1993. 71. Young RS, During MJ, Donnelly DF, Aquila WJ, Perry VL, and Haddad GG. Effect of anoxia on excitatory

amino acids in brain slices of rats and turtles: In vitro microdialysis study. Am J Physiol, 264(33): R716-719, 1993.

72. Xia Y and Haddad GG. Neuroanatomical distribution and binding properties of saxitoxin sites in the rat and

turtle CNS. J Comp Neurol, 330: 363-380, 1993. 73. Jiang C and Haddad GG. Short periods of hypoxia activate a K+ current in central neurons. Brain Res, 64:

352-356, 1993. 74. Kwei S, Jiang C, and Haddad GG. Acute anoxia-induced alterations in MAP2 immunoreactivity and neuronal

morphology in rat hippocampus. Brain Res, 620: 203-210, 1993. 75. Haddad GG and Jiang C. Mechanisms of anoxia-induced depolarization in brainstem neurons: in-vitro current

and voltage clamp studies in the adult rat. Brain Res, 625: 261-268, 1993. 76. D'Andrea L, Rosen CL, and Haddad GG. Severe hypoxemia in children with upper airway obstruction during

sleep does not lead to significant changes in heart rate? Pediatr Pulm, 16: 362-369, 1993. 77. Xia Y, Eisenman D, and Haddad GG. Sulfonylurea receptor expression in rat brain: Effect of chronic hypoxia

during development. Pediatr Res, 34: 634-641, 1993. 78. Xia Y and Haddad GG. Voltage-sensitive Na+ channels increase in number in newborn rat brain after in utero

hypoxia. Brain Res, 635: 339-344, 1994. 79. Friedman JE and Haddad GG. Removal of extracellular sodium prevents anoxia-induced injury in rat CA1

hippocampal neurons. Brain Res, 641: 57-64, 1994. 80. Cummins TR, Xia Y, and Haddad GG. Functional properties of rat and human neocortical voltage-sensitive

sodium currents. J Neurophysiol, 71(3): 1052-1064, 1994. 81. Xia Y and Haddad GG. Postnatal development of voltage-sensitive Na+ channels in rat brain. J Comp Neurol,

345: 279-287, 1994. 82. Narayan D, Krishnan SN, Upender M, Ravikumar TS, Mahoney MJ, Dolan TF, Teebi AS, and Haddad GG.

Unusual inheritance of Primary Ciliary Dyskinesia (Kartagener's Syndrome). J Med Genet, 31: 493-496, 1994. 83. Jiang C and Haddad GG. A direct mechanism for sensing low oxygen levels by central neurons. Proc Nat’l

Acad Sci, USA, 91: 7198-7201, 1994. 84. Jiang C, Cummins TR, and Haddad GG. Membrane ionic currents and properties of freshly dissociated rat

brainstem neurons. Exp Brain Res, 100: 407-420, 1994. 85. Jiang C, Sigworth FJ, and Haddad GG. O2 deprivation activates an ATP-inhibitable K+ channels in substantia

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nigra neurons. J Neurosci, 14: 5590-5602, 1994. 86. Friedman JE and Haddad GG. Anoxia induces an increase in intracellular sodium in rat central neurons. Brain

Res, 663: 329-334, 1994. 87. Jiang C and Haddad GG. Oxygen deprivation inhibits a K+ channel independently of cytosolic factors in central

neurons. J Physiol (London), 481.1: 15-26, 1994. 88. Krishnan SN and Haddad GG. Cloning of glucose transporter-3 (GLUT 3) from rat brain, Life Sciences,

56(14): 1193-1199, 1995. 89. Xia Y, Warshaw JB and Haddad GG. Chronic hypoxia causes opposite effects on glucose transporter 1 mRNA

in mature versus immature rat brain. Brain Res, 675: 224-230, 1995. 90. O'Reilly JP, Jiang C, and Haddad GG. Major differences in response to graded hypoxia between hypoglossal

and neocortical neurons. Brain Res, 683: 179-186, 1995. 91. Krishnan SN, Desai T, Ward DC and Haddad GG. Isolation and chromosomal localization of a human ATP-

regulated potassium channel. Human Genet, 96: 155-160, 1995. 92. O'Reilly JP and Haddad GG. Chronic hypoxia in vivo renders neocortical neurons more vulnerable to

subsequent acute hypoxic stress. Brain Res, 711: 203-210, 1996. 93. Bevensee MO, Cummins TR, Haddad GG, Boron WF and Boyarsky G. pH regulation in single CA1 neurons

acutely isolated from the hippocampi of immature and mature rats. J Physiol (London), 494.2: 315-328, 1996. 94. Marks JD, Friedman JE and Haddad GG. Vulnerability of CA1 neurons to glutamate is developmentally

regulated. Dev Brain Res, 97(2): 194-206, 1996. 95. Jiang C and Haddad GG. Modulation of K+ channels by intracellular ATP in human neocortical neurons. J

Neurophysiol, 77: 93-102, 1997. 96. Haddad GG. K+ ions and channels: Mechanisms of sensing O2 deprivation in central neurons. Kidney Intl, 51:

467-472, 1997. 97. Krishnan SN, Sun Y-A, Mohsenin A, Wyman RJ and Haddad GG. Behavioral and electrophysiologic responses

of Drosophila melanogaster to prolonged periods of anoxia. J Insect Physiol, 43(3): 203-210, 1997. 98. Ma E and Haddad GG. Anoxia regulates gene expression in the central nervous system of Drosophila

melanogaster. Mol Brain Res, 46: 325-328, 1997. 99. Chidekel AS, Friedman JE and Haddad GG. Anoxia-induced neuronal injury: Role of Na+ entry and Na+-

dependent transport. Exp Neurol, 146: 403-413, 1997. 100. Ma E and Haddad GG. Expression and localization of Na+/H+ exchangers in rat central nervous system.

Neuroscience, 79(2): 591-603, 1997. 101. Haddad GG, Sun Y-A, Wyman RJ and Xu T. Genetic basis of tolerance to O2 deprivation in Drosophila

melanogaster. Proc Nat’l Acad Sci, USA, 94: 10809-10812, 1997. 102. O'Reilly J, Cummins TR and Haddad GG. Oxygen deprivation inhibits Na+ current in rat hippocampal neurones

via protein Kinase C. J Physiol (London), 503.3: 479-488, 1997. 103. Fung M-L and Haddad GG. Anoxic-induced depolarization in CA1 hippocampal neurons: Role of Na+-

dependent mechanisms. Brain Res, 762: 97-102, 1997.

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104. Xia Y, Warshaw JB and Haddad GG. Effect of chronic hypoxia on glucose transporters in heart and skeletal muscle of immature and adult rats. Am J Physiol, 273(42): R1734-1741, 1997.

105. Friedman JE, Chow EJ and Haddad GG. State of actin filaments is changed by anoxia in cultured rat

neocortical neurons. Neuroscience, 82(2): 421-427, 1998. 106. Chow E and Haddad GG. Differential effects of anoxia and glutamate on cultured neocortical neurons. Exp

Neurol, 150: 52-59, 1998. 107. Croning MDR and Haddad GG. Comparison of brain slice chamber designs for investigations of oxygen

deprivation in-vitro. J Neurosci Meth, 81: 103-111, 1998. 108. Banasiak KJ and Haddad GG. Hypoxia-induced Apoptosis: Effects of severity of hypoxia and role of p53 in

neuronal cell death. Brain Res, 797: 295-304, 1998. 109. Haddad GG. Mechanisms of anoxia tolerance. A novel approach using a Drosophila model system. Adv Exp

Med Biol, 454: 273-280, 1998. 110. Ma E, Xu T and Haddad GG. Gene regulation by O2 deprivation: An anoxia-regulated novel gene in Drosophila

Melanogaster. Mol Brain Res, 63: 217-224, 1999. 111. Yao H, Ma E, Gu XQ and Haddad GG. Intracellular pH regulation of CA1 neurons in Na+/H+ isoform 1 mutant

mice. J Clin Invest, 104: 637-645, 1999. 112. Liu H, Moczydlowski E and Haddad GG. O2 deprivation inhibits Ca2+ -activated K+ channels via channels via

cytosolic factors in mice neocortical neurons. J Clin Invest, 104: 577-588, 1999. 113. Ma E and Haddad GG. A Drosophila Cdk5α-like molecule and its possible role in response to O2 deprivation.

Biochem Biophys Res Comm, 261: 459-463, 1999. 114. Banasiak BJ, Cronin T and Haddad GG. bcl-2 prolongs neuronal survival in graded hypoxia. Mol Brain Res,

72: 214-225, 1999. 115. Gu XQ and Haddad GG. Drosophila neurons respond differently to hypoxia and cyanide than rat neurons.

Brain Res, 845(1): 6-13, 1999. 116. Xia Y and Haddad GG. Effect of prolonged O2 deprivation on Na+ channels: Differential regulation in adult

versus fetal rat brain. Neuroscience, 94(4): 1231-1243, 1999. 117. Ma E and Haddad GG. Isolation and characterization of the hypoxia-inducible factor 1β in Drosophila

melanogaster. Mol Brain Res, 73: 11-16, 1999. 118. Fung M-L, Croning MDR and Haddad GG. Sodium homeostasis in hippocampal slices during oxygen and

glucose deprivation: Role of voltage-sensitive sodium channels. Neurosci Lett, 5;275(1): 41-44, 1999. 119. Xia Y, Fung M-L, O’Reilly J and Haddad GG. Increased neuronal excitability after long term O2 deprivation is

mediated mainly by sodium channels. Mol Brain Res, 76: 211-219, 2000. 120. Banasiak KJ, Xia Y and Haddad GG. Mechanisms underlying hypoxia-induced neuronal apoptosis. Prog

Neurobiol, 62(3): 215-249, 2000. 121. Schmitt BM, Berger UV, Douglas RM, Bevensee MO, Hediger MA, Haddad GG and Boron WF. Na/HCO3

cotransporters in rat brain: Expression in Glia, Neurons and Choroid Plexus. J Neurosci, 20(18): 6839-6848, 2000.

122. Gu XQ, Yao H and Haddad GG. Effect of extracellular HCO3

- on Na+ channel characteristics in hippocampal

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CA1 neurons. J Neurophysiol, 84: 2477-2483, 2000. 123. Zhang J, Haddad GG and Xia Y. δ-, But not μ- and κ-, opioid receptor activation protects neocortical neurons

from glutamate-induced excitotoxic injury. Brain Res, 885(2): 143-153, 2000. 124. Novotny EJ, Ariyan C, Mason GF, O'Reilly J, Haddad GG and Behar KL. Differential increase in cerebral

cortical glucose oxidative metabolism during rat postnatal development is greater in vivo than in vitro. Brain Res, 888(2): 193-202, 2001.

125. Douglas RM, Schmitt BM, Xia Y, Bevensee MO, Biemesderfer D, Boron WF and Haddad GG. Sodium-

Hydrogen exchangers and Sodium-Bicarbonate transporters: Ontogeny of protein expression in the rat brain. Neuroscience, 102(1): 217-228, 2001.

126. Ma E, Gu XQ,, Wu X, Xu T and Haddad GG. Mutation in pre-RNA editase markedly attenuates neuronal

tolerance to O2 deprivation in Drosophila melanogaster. J Clin Invest, 107(6): 685-693, 2001. 127. Douglas RM, Xu T and Haddad GG. Cell cycle progression & cell division are sensitive to hypoxia in

Drosophila melanogaster embryos. Am J Physiol, 280(5): R1555-R1563, 2001. 128. Gu XQ, Yao H and Haddad GG. Increased neuronal excitability and seizures in the Na+/H+ exchanger null

mutant mouse. Am J Physiol, 281(2): C496-503, 2001. 129. Xia Y and Haddad GG. Major difference in the expression of μ- and δ- opioid receptors between turtle and rat

brain. J Comp Neurol, 436(2): 202-210, 2001. 130. Gu XQ and Haddad GG. Decreased neuronal excitability in hippocampal neurons of mice exposed to cyclic

hypoxia. J Appl Physiol, 91(3): 1245-1250, 2001. 131. Yao H, Gu XQ, Douglas RM and Haddad GG. Role of Na+/H+ exchanger during O2 deprivation in mouse CA1

neurons. Am J Physiol, 281(4): C1205-1210, 2001. 132. Haddad GG and Ma E. Neuronal tolerance to O2 deprivation in Drosophila: Novel approaches using genetic

models. Neuroscientist, 7(6): 538-550, 2001. 133. Chen Q-F, Ma E, Behar KL, Xu T and Haddad GG. Role of trehalose phosphate synthase in anoxia tolerance

and development in Drosophila melanogaster. J Biol Chem, 277(5): 3274-3279, 2002. 134. Gibney GT, Zhang J, Douglas RM, Haddad GG and Xia Y. Na+ - Ca2+ exchanger expression in the developing

rat cortex. Neuroscience, 112(1): 65-73, 2002. 135. Vicencio AG, Eickelberg O, Stankewich MC, Kashgarian M and Haddad GG. Regulation of TGF-beta ligand

and receptor expression in neonatal rat lungs exposed to chronic hypoxia. J Appl Physiol, 93(3): 1123-1130, 2002.

136. Ma E, Tucker MC, Chen Q and Haddad GG. Developmental expression of dADAR and its enzymatic activity in

Drosophila melanogaster. Brain Res Mol Brain Res, 102(1-2): 100-104, 2002. 137. Xia Y, Zhao P, Xue J, Gu XQ, Sun X, Yao H and Haddad GG. Na+ channel expression and neuronal function in

the Na+/H+ exchanger 1 Null Mutant Mouse. J Neurophysiol 89(1): 229-236, 2003. 138. Yao H, Gun XQ and Haddad GG. The role of HCO3

--dependent mechanisms in pHi regulation during O2 deprivation. Neuroscience, 117(1): 29-35, 2003.

139. Lai JCK, White BK, Buerstatte CR, Haddad GG, Novotny Jr. EJ and Behar KL. Chronic hypoxia in

development selectively alters the activities of key enzymes of glucose oxidative metabolism in brain regions. Neurochem Res, 28(6): 933-940, 2003.

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140. Gu XQ and Haddad GG. Maturation of neuronal excitability in hippocampal neurons of mice chronically

exposed to cyclic hypoxia. Am J Physiol Cell Physiol, 284(5): C1156-1163, 2003. 141. Douglas RM, Xue J, Chen JY, Haddad CG, Alper SL and Haddad GG. Chronic intermittent hypoxia decreases

the expression of Na/H exchangers and HCO3-dependent transporters in the mouse central nervous system. J Appl Physiol, 95(1): 292-299, 2003.

142. Sun X, Gu XQ and Haddad GG. Calcium influx via L- and N-type calcium channels activates a transient BK

current in mouse neocortical pyramidal neurons. J Neurosci, 23(9): 3639-3648, 2003. 143. Xue J, Douglas RM, Lim JY, O’Brien GP and Haddad GG. Expression of sodium-hydrogen exchangers and

bicarbonate-dependent transporters in the NHE1 Null Mutant Mouse Brain. Neuroscience, 122(1): 37-46, 2003. . 144. Chen Q-F, Behar KL, Xu T, Fan C and Haddad GG. Expression of Drosophila trehalose phosphate synthase in

HEK-293 cells increases hypoxia tolerance. J Biol Chem, 49: 49113-49118, 2003. 145. Kuan CY, Whitmarsh AJ, Yang DD, Laio G, Schloemer AJ, Dong C, Bao J, Banasiak KJ, Haddad GG, Flavell

RA, Davis RJ and Rakic P. A critical role of neural-specific JNK3 for ischemic apoptosis. Proc Nat’l Acad Sci USA, 100(25): 15184-15189, 2003.

146. Lang KS, Wagner CA, Haddad G, Burenkova O and Geibel JP. Intracellular pH activates membrane-bound

Na+/H+ exchanger and vacuolar H+ATPase in human embryonic kidney (HEK) cells. Cell Physiol Biochem,13: 257-262, 2003.

147. Banasiak KJ, Burenkova O and Haddad GG. Activation of voltage-sensitive sodium channels during oxygen

deprivation leads to apoptotic neuronal death. Neuroscience, 126(1): 31-44, 2004. 148. Gu XQ, Xue J and Haddad GG. Effect of chronically elevated CO2 on CA1 neuronal excitability. Am J Physiol,

287(3): C691-697, 2004. 149. Zhou D, Xue J, Gavrialov O and Haddad GG. Na+/H+ exchanger 1 deficiency alters gene expression in mouse

brain. Physiol Genomics, 18(3): 331-339, 2004. 150. Vicencio AG, Lee CG, Cho SJ, Eickelberg O, Chuu Y, Haddad GG and Elias JA. Conditional overexpression of

bioactive TGF-β1 in neonatal mouse lung: A new model for BPD? Am J Resp Cell Mol Biol, 31: 650-656, 2004. 151. Chen L, Rio DC, Haddad GG and Ma E. Regulatory role of dADAR in ROS metabolism in Drosophila CNS. Mol

Brain Res, 131: 93-100, 2004. 152. Douglas RM, Farahani R, Morcillo P, Kanaan A, Xu T and Haddad GG. Hypoxia induces major effects on cell

cycle kinetics and protein expression in Drosophila melanogaster embryos. Am J Physiol, 288(2): R511-521, 2005.

153. Xia S, Yang J, Su Y, Qian J, Ma E and Haddad GG. Identification of new targets of Drosophila pre-mRNA

deaminase. Physiol Genomics, 20(2): 195-202, 2005. 154. Zhao P, Xue J, Gu XQ and,Haddad GG and Xia Y. Intermittent hypoxia modulates Na+ channel expression in

developing mouse brain. Int J Develop Neurosci, 23:327-333, 2005. 155. Fan C, Iacobas DA, Zhou D, Chen QF, Lai JK, Gavrialov O and Haddad GG. Gene expression and phenotypic

characterization of mouse heart after chronic intermittent or constant hypoxia. Physiol Genomics, 22(3):292-307, 2005.

156. Ryu J, Vicencio AG, Yeager ME, Kashgarian M, Haddad GG and Eickelberg O. Dynamic regulation of matrix

metalloproteinase expression in human and mouse lung development. Thromb Haemos, 94(1):175-83, 2005.

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157. Haddad, GG. Tolerance to low O2: Lessons from invertebrate genetic models. Exper Physiol. 91(2):277-82,

2006. 158. Kanaan A, Farahani R, Douglas RM, LaManna JC and Haddad GG. Effect of chronic continuous or

intermittent hypoxia and re-oxygenation on cerebral capillary density and myelination. Am J Physiol Regul Integr Comp Physiol. 290(4):R1105-14, 2006.

159. Douglas RM, Lai JCK, Bian S, Cummins L, Moczydlowski E,

and Haddad GG. The Calcium-Sensitive

Potassium Channel (BK/Maxi K) is present in the Inner Mitochondrial Membrane of Rat Brain. Neuroscience, 139(4):1249-61, 2006.

160. Li G, Vicencio AG, Ryu J, Zhou D, Xue J, Kanaan A, Gavrialov O and Haddad GG. Effect of Carbon Dioxide

on Neonatal Mouse Lung: A Genomic Approach. J Appl Physiol 101(6):1556-64, 2006. 161. Iacobas DA, Fan C, Iacobas S, Spray DC, and Haddad GG. Transcriptomic changes in developing kidney

exposed to chronic hypoxia. Biochem Biophys Res Commun, 13;349(1):329-38, 2006. 162. Sun X, Zhou D, Zhang P, Moczydlowski E, Haddad GG. Beta-Subunit-Dependent Modulation of Hslo BK

Current by Arachidonic Acid. J Neurophysiol, 97(1):62-9, 2007. 163. Yao H, Shu Y, Wang J, Brinkman BC, and Haddad GG. Factors influencing cell fate in the infarct rim .J

Neurochemistry, 100(5):1224-33, 2007. 164. Douglas R, Miyasaka N, Takahashi K, Latuszek-Barrantes A, Haddad GG, and Hetherington H. Chronic

intermittent but not constant hypoxia decreases NAA/Cr ratios in mouse hippocampus. Am J Physiol Regul Integr Comp Physiol, 292(3):R1254-9, 2007.

165. Gu XQ, Kanaan A, Yao H, and Haddad GG. Chronic high inspired CO2 decreases excitability of mouse

hippocampal neurons. J Neurophysiol, 97(2):1833-8, 2007. 166. Huang H and Haddad GG. The Drosophila dMRP4 regulates responsiveness to O2 deprivation and

development under hypoxia. Physiol Genomics, 29(3):260-6, 2007. 167. Scafidi S, Douglas RM, Farahani R, Banasiak KJ and Haddad GG. Prostaglandin transporter expression in

mouse brain during development and in response to hypoxia. Neuroscience, 146(3):1150-7, 2007. 168. Gu XQ, Siemen D, Parvez S, Cheng Y, Xue J, Zhou D, Sun X, Jonas EA and Haddad GG. Hypoxia increases

BK channel activity in the inner mitochondrial membrane, Biochem Biophys Res Commun, 358(1):311-6, 2007.

169. Xue J, Zhou D, Yao H, Gavrialov O, McConnell MJ, Gelb BD and Haddad GG. Novel functional interaction

between Na+/H+ exchanger 1 and tyrosine phosphatase SHP-2. Am J Physiol Regul Integr Comp Physiol, 292(6):R2406-16, 2007.

170. Zhou D, Xue J, Chen J, Morcillo P, Lambert JD, White KP and Haddad GG. Experimental selection for

Drosophila survival in extremely low O2 environments. PLOS One, 2(5) e490, 2007. 171. Yao H, Sun X, Gu X, Wang J and Haddad GG. Cell death in the ischemic infarct rim. J Neurochemistry,

103(4):1644-53, 2007. 172. Chen LM, Choi I, Haddad GG, Boron WF. Chronic continuous hypoxia decreases the expression of SLC4A7

(NBCn1) and SLC4A10 (NCBE) in mouse brain. Am J Physiol Regul Integr Comp Physiol. 293(6):R2412-20, 2007.

173. Kanaan A, Douglas RM, Alper SA, Boron WF and Haddad GG. Effect of chronic elevated carbon dioxide on

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the expression of acid-base transporters in the neonatal and adult mouse. Am J Physiol Regul Integr Comp Physiol, 293(3):R1294-302, 2007.

174. Xue J, Zhou D, Yao H, Haddad GG. Role of transporters and ion channels in neuronal injury under hypoxia.

Am J Physiol Regul Integr Comp Physiol. 294(2):R2451-7, 2008. 175. Sun X, Yao H, Zhou D, Gu X, Haddad GG. Modulation of hSlo BK current inactivation by fatty acid esters of

CoA. J Neurochemistry, 104(5):1394-403, 2008. 176. Zhou D, Wang J, Zapala MA, Xue J, Schork NJ, Haddad GG. Gene expression in mouse brain following

chronic hypoxia: role of sarcospan in glial cell death. Physiol Genomics, 32(3):370-9, 2008. 177. Ruffin VA, Gu XQ, Zhou D, Douglas RM, Sun X, Trouth CO, Haddad GG. The sodium-activated potassium

channel Slack is modulated by hypercapnia and acidosis. Neuroscience, 151(2):410-8, 2008. 178. Alejandre-Alcazar MA, Michiels-Corsten M, Vicencio AG, Reiss I, Ryu J, de Krijger RR, Haddad GG,

Tibboel D, Seeger W, Eickelberg O, Morty RE. TGF-beta signaling is dynamically regulated during the alveolarization of rodent and human lungs. Dev Dyn., 237(1):259-69, 2008.

179. Farahani R., Kanaan A, Gavrialov O, Brunnert S, Douglas R, Morcillo P, and Haddad GG. Differential

effects of chronic intermittent and constant hypoxia on postnatal growth and development. Pediatric Pulmonology, 43(1):20-8, 2008.

180. Ruis J, Guma M, Schachtrup C, Akassoglou K, Zinkernagel AS, Nizet V, Johnson RS, Haddad GG, Karin M..

NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha. Nature, 453(7196):807-11, 2008.

181. Iacobas DA, Fan C, Iacobas S, Haddad GG. Integrated transcriptomic response to cardiac chronic hypoxia:

translation regulators and response to stress in cell survival. Funct Integr Genomics, 8(3):265-275, 2008. 182. Cheng Y, Gu XQ, Bednarczyk P, Wiedemann FR, Haddad GG, Siemen D. Hypoxia increases activity of the

BK-channel in the inner mitochondrial membrane and reduces activity of the permeability transition pore. Cell Physiol Biochem. 22(1-4):127-136, 2008.

183. Chen LM, Haddad GG, Boron WF. Effects of chronic continuous hypoxia on the expression of SLC4A8

(NDCBE) in neonatal versus adult mouse brain. Brain Res. 1238:85-92, 2008. 184. Zhou D, Xue J, Lai JC, Schork NJ, White KP, Haddad GG. Mechanisms Underlying Hypoxia Tolerance in

Drosophila melanogaster: hairy as a metabolic switch. PLoS Genet. 4(10):e1000221, 2008. 185. Boutin AT, Weidemann A, Fu Z, Mesropian L, Gradin K, Jamora C, Wiesener M, Eckhardt KU, Koch CJ,

Ellies LG, Haddad G, Haase VH, Simon MC, Poellinger L, Powell FL, Johnson RS. Epidermal sensing of oxygen is essential for systemic hypoxic response. Cell. 133(2):223-234, 2008.

186. Yao H, Felfly H, Wang J, Zhou D, Haddad GG. DIDS protects against neuronal injury by blocking Toll-like

receptor 2 activated-mechanisms. J of Neurochem. 108(3):835-846, 2009.

187. Azad P, Zhou D, Russo E, Haddad GG. Distinct Mechanisms Underlying Tolerance to Intermittent and Constant Hypoxia in Drosophila melanogaster. PLosOne 4(4):e5371, 2009.

188. Zhou D, Visk DW, Haddad GG. Drosophila, a golden bug, for the dissection of the genetic basis of tolerance

and susceptibility to hypoxia. Pediatr Res. 66(3):239-247, 2009.

189. Guma M, Rius J, Duong-Polk KX, Haddad GG, Lindsey JD, Karin M. Genetic and pharmacological inhibition of JNK ameliorates hypoxia-induced retinopathy through interference with VEGF expression. Proc Natl Acad Sci U S A. 106(21):8760-8765, 2009.

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190. Feala JD, Coquin L, Zhou D, Haddad GG, Paternostro G, McCulloch AD. Metabolism as means for

hypoxia adaptation: metabolic profiling and flux balance analysis. BMC Syst Biol. 2009 Sep 9;3:91.

191. Sun X, Yao H, Wang J, Haddad GG. Insulin/PI3K signaling protects dentate neurons from oxygen-glucose deprivation in organotypic hippocampal slice cultures. J. Neurochem. 2009 Oct 26.

192. Iacobas DA, Iacobas S, Haddad, GG. Heart rhythm genomic fabric in hypoxia. In Press, Biochem Biophys

Res Commun. 2009.

Original Manuscripts in Revision or Submitted 193. Gu XQ, Ma E and Haddad GG. The role of pre-mRNA editing on Na+ channel function in Drosophila

melanogaster.

194. Robert M. Douglas, Amjad Kanaan, Maria del Carmen Rivero, Laura L. Dugan, Gabriel G. Haddad, Sameh S. Ali . Neuronal death during combined intermittent hypoxia/hypercapnia is due to mitochondrial dysfunction.

195. Huiwen W. Zhao, Dan Zhou, Victor Nizet, Steven A.Wasserman, and Gabriel G. Haddad . Decreased JNK phosphorylation protects against oxidant–induced death in Drosophila melanogaster.

196. Julie Ryu, Gregory P. Heldt, Mary Nguyen, Orit Gavrialov, Gabriel G. Haddad. Chronic hypercapnia alters lung function through changes in matrix composition in mouse pups.

Reviews and Chapters

197. Epstein RA, Haddad GG, Epstein RA, Epstein MAF, Mazza NM, Law HS, Katz JS, and Mellins RB. Breath-to-breath control of ventilation in normal infants during sleep. In: Regulation of Respiration during Sleep and Anesthesia. Edited by RS Fitzgerald, H Gautier, and S Lahiri. Plenum Press, New York, pp. 85-92, 1978.

198. Haddad GG, Leistner HL, Epstein RA, Epstein MAF, and Mellins RB. Abnormal cardiorespiratory function in infants with aborted Sudden Infant Death Syndrome during sleep. International Symposium on Fetal and Neonatal Physiologic Measurements, Oxford. Pitman Medical Limited, pp. 188-193, 1980.

199. Mellins RB and Haddad GG. Sudden Infant Death Syndrome. In: Nelson Textbook of Pediatrics, 12th Edition. Saunders, PA, pp. 1770-1773, 1983.

200. Haddad GG and Mellins RB. Cardiorespiratory aspects of SIDS: In: An overview in Sudden Infant Death Syndrome. Edited by JT Tildon, LN Roeder and A Steinschneider. Academic Press, New York, pp. 357-374, 1983.

201. Haddad GG, Schaeffer JI, and Bazzy AR. Postnatal maturation of the ventilatory response to hypoxia. In: Hypoxia, Exercise and Altitude. Alan R. Liss Inc., New York, pp. 39-50, 1983.

202. Mellins RB and Haddad GG. Respiratory control in early life: An overview. In: Hypoxia, Exercise and Altitude. Alan R. Liss Inc., New York, pp. 3-15, 1983.

203. Mellins RB and Haddad GG. Cardiorespiratory control in Sudden Infant Death Syndrome. In: Hypoxia, Exercise and Altitude. Alan R. Liss Inc., New York, pp. 51-56, 1983.

204. Haddad GG and Mellins RB. Hypoxia and respiratory control in early life. Annu Rev Physiol, 46: 629-643,

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1984.

205. Haddad GG. Control of Breathing in Children. In: Contemporary Issues in Pulmonary Disease. Edited by NH Edelman and T Santiago. Churchill Livingstone Inc., pp. 57-80, 1986.

206. Haddad GG and Akabas SR. Adaptation of respiratory muscles to acute and chronic stress: Considerations on energy and fuels. Clin Chest Med 7: 79-89, 1986.

207. Haddad GG, Bazzy AR, and Pang LM. Response of respiratory muscles to acute loading in adult sheep. In: Respiratory Muscles and their Neuromotor Control. Edited by GC Sieck, SC Gandevia and WE Cameron. Alan R. Liss, New York, pp. 307-316, 1987.

208. Mellins RB and Haddad GG. Sudden Infant Death Syndrome. In: Nelson Textbook of Pediatrics 13th Edition. Saunders, PA, pp. 1480-1482, 1987.

209. Haddad GG and Donnelly DF. Chemo-baroreceptors - brainstem interactions: critical role in early life. In: Sudden Infant Death Syndrome: Cardiorespiratory mechanisms and interventions. New York Academy of Sciences, pp. 221-227, 1988.

210. Haddad GG. Failure of the respiratory neuromuscular pump in awake sheep. In: Sudden Infant Death Syndrome: Risk factors and basic mechanisms. Section 4, Respiratory Control. Edited by RM Harper and HJ Hoffman. PMA Publ. Co., New York, pp. 379-386, 1988.

211. O’Brodovich HM and Haddad GG. The functional basis for pulmonary pathology, In: Kendigs 5th edition, Disorders of the Respiratory Tract in Children. Edited by V Chernick. WB Saunders, PA, pp. 3-47, 1990.

212. Dekin MS and Haddad GG. Membrane and cellular properties in oscillating networks: implications for respiration. In: J Appl Physiol, invited article, 69: 809-821, 1990.

213. Haddad GG and Bazzy AR. Respiratory muscle function: Implications for ventilatory failure. In: Basic Mechanisms of Pediatric Respiratory Disease: Cellular and Integrative, Section III. Edited by V Chernick and RB Mellins. B.C. Decker, Inc,, Philadelphia, PA, pp. 100-113, 1991.

214. Haddad GG. Cellular and membrane properties of brainstem neurons in early life. In: Developmental

Neurobiology of breathing. Lung Biology in Health and Disease, Vol. 53. Edited by GG Haddad and J Farber. New York, Marcel Dekker, pp. 155-175, 1991.

215. Haddad GG and Rosen CL. Ventilatory response to hypoxia: Integrated, cellular and molecular aspects. In:

Developmental Neurobiology of breathing. Lung Biology in Health and Disease, Vol. 53. Edited by GG Haddad and J Farber. Marcel Dekker, New York, pp. 591-614, 1991.

216. Donnelly DF and Haddad GG. Carotid chemotransduction: Mechanisms & development. Symposium on Sleep

and Cardio Respiratory Control. John Libbey Eurotext Limited, France, 217: 35-43, 1991. 217. Haddad GG and Pérez-Fontán J Julio. The Respiratory System. In: Nelson Textbook of Pediatrics. Edited by

Behrman and Vaughan. Saunders, PA, 15th Edition, pp. 1035-1045, 1992. 218. Haddad GG. The multi-faceted sudden infant death syndrome: Controversies and Hope. Curr Opin Pediatr,

invited article, 4(3): 426-430, 1992. 219. Haddad GG and Jiang C. Neuronal membrane properties during O2 deprivation: In vitro intracellular studies.

In: Respiratory Control: Peripheral and Central Mechanisms. Edited by D Speck, M Dekin, Revelette WR and D Frazier. pp. 12-14, 1993.

220. Haddad GG and Jiang C. O2 deprivation in the central nervous system: On mechanisms of neuronal response,

differential sensitivity and injury. Prog Neurobiol, 40: 277-318, 1993. 221. Haddad GG, Donnelly DF, and Bazzy AR. Developmental Control of Respiration: Neurobiological Basis. In:

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Regulation of breathing. Lung Biology in Health and Disease. Edited by JA Dempsey and AI Pack. New York, Marcel Dekker, (Vol. 79) pp. 743-785, 1994.

222. Haddad GG and Jiang C. Mechanisms of neuronal survival during hypoxia: ATP-sensitive K+ channels. Biol of Neonate, 65: 160-165, 1994.

223. Haddad GG. Response of Brainstem & Cortical Neurons to O2 Deprivation. In: Ventral Brainstem Mechanisms

and Control of Respiration and Blood Pressure. Edited by O Trouth. New York, Marcel Dekker, (Vol. 82) pp. 639-651, 1995.

224. Haddad GG. Developmental and Pathophysiologic Aspects of respiratory control. In: Ventral Brainstem

Mechanisms and Control of Respiration and Blood Pressure. Edited by O Trouth. Marcel Dekker, New York, (Vol. 82) pp. 695-700, 1995.

225. Haddad GG. O2 deprivation in tolerant & non-tolerant organisms: Phylogeny and ontogeny. In: Tissue

Oxygen: Developmental, Molecular & Integrated Function. Edited by Gabriel G. Haddad and George Lister. Marcel Dekker, New York, Vol. 95, pp. 573-594, 1996.

226. Haddad GG. Membrane proteins and transport during O2 deprivation. In: Tissue Oxygen: Developmental,

Molecular & Integrated Function. Edited by Gabriel G. Haddad and George Lister. Marcel Dekker, New York, Vol. 95, pp. 81-99, 1996.

227. Haddad GG and Pérez-Fontán J Julio. Development of the Respiratory System. In: Nelson Textbook of

Pediatrics. Edited by Behrman, Kliegman and Arvin. Saunders, PA, 15th Edition, pp. 1165-1167, 1996. 228. Haddad GG. Regulation of Respiration. In: Nelson Textbook of Pediatrics. Edited by Behrman, Kliegman and

Arvin. Saunders, PA, 15th Edition, pp. 1167-1170, 1996. 229. Haddad GG and Pérez-Fontán J Julio. Respiratory Function and Approach to Respiratory Disease. In: Nelson

Textbook of Pediatrics. Edited by Behrman, Kliegman and Arvin. Saunders, PA, 15th Edition, pp. 1170-1177, 1996.

230. Haddad GG and Pérez-Fontán J Julio. Respiratory Failure. In: Nelson Textbook of Pediatrics. Edited by

Behrman, et al,. Saunders, PA, 15th Edition, pp. 1177-1180, 1996. 231. Haddad GG and Pérez-Fontán J Julio. Defense Mechanisms and Metabolic Functions of the Lung. In: Nelson

Textbook of Pediatrics. Edited by Behrman, et al. Saunders, PA, 15th Edition, pp. 1180-1181, 1996. 232. Rosen CL and Haddad GG. Obstructive sleep apnea and hypoventilation in children. In: Nelson Textbook of

Pediatrics. Edited by Behrman, Kliegman and Arvin. Saunders, PA, 15th Edition, pp. 1195-1197, 1996. 233. Haddad GG. Central hypoventilation syndromes. In: Nelson Textbook of Pediatrics. Edited by Behrman,

Kliegman and Arvin. Saunders, PA, 15th Edition, pp. 1260-1261, 1996. 234. Haddad GG. O2-sensing in neurons: direct and indirect modulation of ion channels. International Workshop on

Oxygen Regulation of Ion Channels and Gene Expression. Madrid, Spain, pg. 55, 1996. 235. Haddad GG and Jiang C. O2-sensing mechanisms in excitable cells: Role of plasma membrane K+ channels.

Annu Rev Physiol, Invited article, 59: 23-43, 1997. 236. Donnelly DF and Haddad GG. Possible role of neuroepithelial bodies as airway chemoreceptors. In: Cellular

and Molecular Biology of Airway Chemoreceptors. Medical Intelligence Unit, Molecular Biology Series. Edited by E. Cutz. R.G. Landes Co., Austin, TX, pp. 35-45, 1997.

237. Haddad GG. Oxygen sensing in neurons: Direct and indirect modulation of ion channels. In: Oxygen

Regulation of Ion Channels and Gene Expression. Edited by J Lopez-Barneo and EK Weir. Futura Publishing Co., Armonk, NY, pp. 285-293, 1998.

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238. Haddad GG. Mechanisms of Anoxia Tolerance: A Novel Approach Using A Drosophila Model System. In:

Oxygen Transport to Tissue XX. Advances in Experimental Medicine and Biology Series. Edited by AG Hudetz and D. Bruley. Plenum Publishing, New York, Vol. 454: 273, 1998.

239. Rosen CL, Bazzy-Asaad A and Haddad GG. Respiratory Control in Children - Clinical Aspects. In: Control of

Breathing in Health and Disease. Lung Biology in Health and Disease Series. Edited by M.D. Altose. Marcel Dekker, New York, Vol. 135(9), pp. 289-366, 1999.

240. Haddad GG. Use of genetic models in respiratory neurobiology and sleep. In: Current Opinion in Pulmonary

Medicine. Edited by K.P. Strohl. Lippincott Williams & Wilkins, Philadelphia, PA, Vol. 5, Issue 6, pp. 349-354, 1999.

241. Haddad GG and Pérez-Fontán J Julio. Development of the Respiratory System. In: Nelson Textbook of

Pediatrics. Edited by Behrman, Kliegman and Arvin. Saunders, PA, 16th Edition, pp. 1235-1238, 2000. 242. Haddad GG. Regulation of Respiration. In: Nelson Textbook of Pediatrics. Edited by Behrman, et al. Saunders,

PA, 16th Edition, pp. 1238-1240, 2000. 243. Pérez-Fontán J Julio and Haddad GG. Respiratory Pathophysiology. In: Nelson Textbook of Pediatrics. Edited

by Behrman, et al,. Saunders, PA, 16th Edition, pp. 1240-1251, 2000. 244. Haddad GG and Pérez-Fontán J Julio. Defense Mechanisms and Metabolic Functions of the Lung. In: Nelson

Textbook of Pediatrics. Edited by Behrman, et al. Saunders, PA, 16th Edition, pp. 1252-1253, 2000. 245. Haddad GG and Palazzo RM. Diagnostic Approach to Respiratory Disease. In: Nelson Textbook of Pediatrics.

Edited by Behrman, et al,. Saunders, PA, 16th Edition, pp. 1253-1258, 2000. 246. Rosen CL and Haddad GG. Obstructive sleep apnea and hypoventilation in children. In: Nelson Textbook of

Pediatrics. Edited by Behrman, Kliegman and Arvin. Saunders, PA, 16th Edition, pp. 1268-1271, 2000. 247. Haddad GG. Primary Ciliary Dyskinesia (Immotile Cilia Syndrome). In: Nelson Textbook of Pediatrics. Edited

by Behrman, et al. Saunders, PA, 16th Edition, pp. 1327-1328, 2000. 248. Haddad GG. Drosophila Genes & Anoxia. In: Encyclopedia of Stress. Edited by G. Fink. Academic Press,

California, pp. 746-752, 2000 . 249. Haddad GG. Enhancing our understanding of the molecular responses to hypoxia in mammals using

Drosophila melanogaster. J Appl Physiol, invited article, 88: 1481-1487, 2000 . 250. Haddad GG and Liu H. Different O2-sensing mechanisms by different K+ channels. In: Arterial

chemoreceptors: Oxygen sensing-From molecule to man. Edited by S Lahiri and N Prabhakar. Kluwer Academic/Plenum Publishers, New York, Vol. 475: 441, 2000.

251. Ma E and Haddad GG. Cell and Molecular Responses to Hypoxic Stress. In: Environmental Stressors and Gene

Responses. Edited by KB Storey and JM Storey. JAI Press, Stamford, CT, Vol. 1: 89-97, 2000 . 252. Haddad GG. Study of anoxia tolerance: Use of a novel genetic approach. In: Genetic models in

cardiorespiratory biology. Lung Biology in Health and Disease Series. Edited by GG Haddad and T Xu. Marcel Dekker, New York, Vol. 156(6): 139-151, 2001.

253. Turenchalk, GS, Potter CJ, Haddad GG and Xu T. Drosophila as a Genetic Model System for understanding

Human Biology and Disease. In: Genetic models in cardiorespiratory biology. Lung Biology in Health and Disease Series. Edited by GG Haddad and T Xu. Marcel Dekker, New York, Vol. 156(6): 1-20, 2001.

254. Haddad GG. Assessment of Pulmonary Function. In: Textbook of Clinical Pediatrics. Edited by AY Elzouki,

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HA Harfi and H Nazer. Lippincott Williams & Wilkins, Philadelphia, PA, pp. 645-647, 2001. 255. Haddad GG. The Physiology and Pathophysiology of Cough. In: Textbook of Clinical Pediatrics. Edited by AY

Elzouki, HA Harfi and H Nazer. Lippincott Williams & Wilkins, Philadelphia, PA, pp. 655-657, 2001. 256. Haddad GG. Sudden Infant Death Syndrome. In: Textbook of Clinical Pediatrics. Edited by AY Elzouki, HA

Harfi and H Nazer. Lippincott Williams & Wilkins, Philadelphia, PA, pp. 669-670, 2001. 257. Haddad GG. Upper Airway Obstruction during sleep. In: Textbook of Clinical Pediatrics. Edited by AY

Elzouki, HA Harfi and H Nazer. Lippincott Williams & Wilkins, Philadelphia, PA, pp. 679-681, 2001. 258. Ma E and Haddad GG. Slot-blot hybridization in studying gene expression during oxygen deprivation. Methods

Mol Biol, 196: 139-145, 2002. 259. Haddad GG. Cellular and molecular mechanisms in hypoxic injury or adaptation. In: Basic Mechanisms of

Pediatric Respiratory Disease, 2nd Edition. Edited by GG Haddad, SH Abman and V Chernick. B.C. Decker, Hamilton, Ontario, Canada, Chapter 23: pgs. 312-327, 2002.

260. Haddad GG. Respiratory control in the newborn: Comparative physiology and clinical disorders. In:

Respiratory Control and Disorders in the Newborn. Lung Biology in Health and Disease. Edited by O.P. Mathew. Marcel Dekker, New York, NY, Volume 173: 1-13, 2003.

261. Haddad GG. O2 sensing in neurons: Evidence and requirement for a multitude of sensors. In: Oxygen Sensing:

Responses and Adaptation to Hypoxia. Lung Biology in Health and Disease. Edited by S. Lahiri, G.L. Semezna and N.R. Prabhakar. Marcel Dekker, New York, NY, Volume 175: 619-631, 2003.

262. Douglas RM and Haddad GG. Effect of oxygen deprivation on cell cycle activity: a profile of delay and arrest.

In: Genetics Models in Applied Physiology, J Appl Physiol, invited article, 94(5): 2068-2083, 2003. 263. Farahani R and Haddad GG. Understanding the molecular responses to hypoxia using Drosophila as a genetic

model. In: Respiratory Physiology & Neurobiology (Review), 135(2-3): 221-229, 2003. 264. Zhou D and Haddad GG. Oxygen sensing mechanisms in the fetus and neonate. In: Fetal and Neonatal

Physiology, 3rd Edition. Edited by R Poling, W Fox and S Abman. WB Saunders, PA, 88: 900-905, 2004. 265. Chen QF and Haddad GG. Role of trehalose phosphate synthase and trehalose during hypoxia: From flies to

mammals. J Exp Biol (Review) 18: 3125-3129, 2004. 266. Yao H and Haddad GG. Calcium and pH homeostasis in neurons during hypoxia and ischemia. Cell Calcium

(Review), 36(34): 247-255, 2004. 267. Haddad GG. The control of respiration. In:Life Sciences – Principles of Medical Biology. Edited by EE Bittar

and N Bittar. Springer New York. 94-113, 2004. 268. Powell F, Heldt G and Haddad GG. Respiratory Physiology in Critical Care. Rogers Textbook of Pediatric

Intensive Care, 4th ed., pp. 631-661, 2008. 269. Haddad GG. Genes and survival to low O2 environment: Potential insights from Drosophila. Brain

Hypoxia and Ischemia:with special emphasis on development. Eds, GG Haddad, SP Yu, Springer, pp, 323-334, 2008.

270. Douglas RM, Haddad GG. Can O2 dysregulation induce premature aging? Physiology. 23:333-349, 2008. 271. Haddad GG. The Na(+)/H(+) exchanger: a target for therapeutic intervention in cerebral ischemia. In:

New Strategies in Stroke Intervention: Ionic Transporters, Pumps and New Channels. In Press 2008.

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272. Gu XQ, Yao H, Haddad GG. Effect of hypoxia/ischemia on voltage-dependent channels. In: Structure, Function and Modulation of Neuronal Voltage-Gated Ion Channels. Gribkoff V. and Kaczmarek L. (Eds.) Wiley & Sons. 251-277, 2009.

273. Ramirez MI, Gern JE, Cutting G, Hagood JS, Whitsett J, Abam S, Barst R, Haddad GG, Prabhakar NR,

Martinez FD, Tepper R, Wood RE, Accurso F, Teague WG, Venegas J, Cole FW, Wright RJ, Gauda E. Strategic plan for Pediatric Respiratory Diseases Research: an NHLBI Working Group Report, 2008.

274. Castro M, Ramirez MI, Gern JE, Cutting G, Redding G, Hagood JS, Whitsett J, Abman S, Raj JU, Barst R,

Kato GJ, Gozal D, Haddad GG, Prabhakar NR, Gauda E, Martinez FD, Tepper R, Wood RE, Accurso F, Teague WG, Venegas J, Cole FS, Wright RJ. Strategic plan for Pediatric Respiratory Diseases Research: an NHLBI Working Group Report. Proc Am Thorac Soc. 2009 Jan 15;6(1):1-10.

275. Abman S, Jobe A, Chernick V, Blaisdell C, Castro M, Ramirez MI, Gern JE, Cutting G, Redding G, Hagood

JS, Whitsett J, Abman S, Raj JU, Barst R, Kato GJ, Gozal D, Haddad GG, Prabhakar NR, Gauda E, Martinez FD, Tepper R, Wood RE, Accurso F, Teague WG, Venegas J, Cole FS, Wright RJ, Gail D, Hamvas A, Kercsmar C, Kiley J, Weinmann G. Strategic plan for pediatric respiratory diseases research: an NHLBI working group report. Pediatr Pulmonol. 2009 Jan;44(1):2-13.

276. Azad P, Haddad GG. Survival in Acute and Severe Low O2 Environment: Use of a Genetic Model System.

In: Hypoxia and Consequences. From Molecule to Malady. Eds, C Peers, GG Haddad, NS Chandel, Annals of the New York Academy of Sciences, 2009, Oct 1177:39-47.

277. Peers C, Chandel NS, Haddad GG. Introduction to hypoxia and consequences. In: Hypoxia and

Consequences. From Molecule to Malady. Eds, C Peers, GG Haddad, NS Chandel, Annals of the New York Academy of Sciences, 2009, Oct 1177:1.

278. Firth AL, Oleksandr P, Brevnova EE, Burg ED, Powell F, Haddad GG, Yuan JX-J. Hypoxia Selectively

Ihhibits KCNA5 Channels in Pulmonary Artery Smooth Muscle Cells. In: Hypoxia and Consequences. From Molecule to Malady. Eds, C Peers, GG Haddad, NS Chandel, Annals of the New York Academy of Sciences, 2009.

Book Publications Developmental Neurobiology of Breathing. Lung Biology in Health and Disease, Eds, GG Haddad and JP Farber, Marcel Dekker, NY, 1991. Tissue Oxygen Deprivation: From Molecular to Integrated Function. Lung Biology Series, Eds, GG Haddad and G Lister, Marcel Dekker, NY, 1996. Genetic Models in Cardiorespiratory Biology. Lung Biology in Health and Disease, Eds, GG Haddad and T Xu, Marcel Dekker, NY, 2001. Basic Mechanisms of Pediatric Respiratory Disease, 2nd Edition. Eds, GG Haddad, SH Abman and V Chernick, B.C. Decker, Inc, Hamilton, Ontario, Canada, 2002. Brain Hypoxia and Ischemia:with special emphasis on development. Eds, GG Haddad, SP Yu, Springer, 2008. Hypoxia and Consequences. From Molecule to Malady. Eds, C Peers, GG Haddad, NS Chandel, Annals of the New York Academy of Sciences, 2009.

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ABSTRACTS (1989 - Present) 1. Haddad GG and Donnelly DF. Maturation of hypoglossal neuronal response to hypoxia in rats. In-vitro

intracellular studies. Fed Proc, 3: A403, 1989. 2. Donnelly DF and Haddad GG. Hypoxia-induced changes in membrane potential and repetitive firing properties

of medullary neurons: in-vitro studies in adult rats. Fed Proc, 3: A403, 1989. 3. Haddad GG and Donnelly DF. Tolerance to anoxia in newborn mammals and reptiles: Intracellular neuronal

studies. Soc for Neurosci, 15: 1194, 1989. 4. Xia Y and Haddad GG. Ontogeny of opioid receptors in the rat brainstem. Soc for Neurosci, 15: 99, 1989. 5. Bazzy AR, Kim YJ, Donnelly DF, and Haddad GG. Neuromuscular transmission failure can be a mechanism for

diaphragmatic fatigue in-vivo. Am Rev Respir Dis, 141 :(4) A366, 1990. 6. Haddad GG, Xia Y, and Bang R. Cytochrome oxidase activity is much higher in rat than in turtle central

nervous system (CNS). Fed Proc, 4: 4857, 1990. 7. Xia Y and Haddad GG. Ontogeny and distribution of glutamate receptors in the rat brainstem. Fed Proc, 4:

A406, 1990. 8. Donnelly DF, Cummins TR, and Haddad GG. Brainstem neurons respond differently to O2 deprivation than

cortical neurons. Fed Proc 3, 4: A406, 1990. 9. Cummins TR, Donnelly DF, and Haddad GG. Effect of cyanide (CN) on hippocampal membrane currents

studied by whole cell patch: developmental aspects. Fed Proc, 4: A405, 1990. 10. Feldman JD, Bazzy AR, Fournier M, and Haddad GG. Is the neonatal diaphragm more susceptible to

neuromuscular transmission failure than the adult? Soc Pediatr Res, 27: 354A, 1990. 11. Kim YJ, Bazzy AR, and Haddad GG. Utilization of diaphragm glycogen by lambs subjected to severe inspiratory

flow resistive (IFR) loads. Soc Pediatr Res, 27: 358A, 1990. 12. Boyarsky G, Cummins TR, Haddad GG, and Boron WF. Intracellular pH regulation in single mammalian

hippocampal CA1 neurons. Soc for Neurosci, 16: 429, 1990. 13. Donnelly DF, Cummins TR, and Haddad GG. Differential response to cyanide and hypoxia of adult carotid

body glomus cells. Soc for Neurosci, 16: 1063, 1990. 14. Jiang C, Haddad GG, and Agulian S. Effect of anoxia on intracellular and extracellular K+ in hypoglossal

neurons studied in-vitro. Soc for Neurosci, 16: 277, 1990. 15. Cummins TR, Donnelly DF, and Haddad GG. Effect of histotoxic anoxia on hypoglossal neurons studied by

whole cell patch clamp. Soc for Neurosci, 16: 1061, 1990. 16. Xia Y and Haddad GG. Ontogeny and distribution of GABA receptors in the rat brainstem and higher brain

areas. Soc for Neurosci, 16: 555, 1990. 17. Rosen CL, D'Andrea L, and Haddad GG. Adult criteria for obstructive sleep apnea do not identify serious

airway obstruction in children. Am Rev Respir Dis, 143: A388, 1991. 18. Haddad GG and Jiang C. Hypoglossal neuronal and membrane properties during O2 deprivation: role of ATP-

sensitive K+ channels. Am Rev Respir Dis, 143: A791, 1991. 19. Rosen CL, D'Andrea L, and Haddad GG. Reduction of REM sleep in children with severe upper airway

35

obstruction. Soc Pediatr Res, 29: 376A, 1991. 20. D'Andrea LA, Rosen CL, and Haddad GG. Do children with airway obstruction during sleep have significant

changes in heart rate during severe desaturations? Soc Pediatr Res, 29: 369A, 1991. 21. Xia Y, Eisenman DJ, and Haddad GG. Hypoxia increases KATP channels in developing rat CNS. Third IBRO

World Congress of Neurosci, 68, 1991. 22. Jiang C, Agulian S, and Haddad GG. The effect of anoxia on Cl- homeostasis in hypoglossal neurons: in-vitro

intracellular and extracellular studies in adult and neonatal rats. Third IBRO World Congress of Neurosci, 327, 1991.

23. Bazzy-Asaad AR, Donnelly DF, and Haddad GG. Evidence for failure of neuromuscular transmission in the

newborn diaphragm. Soc for Neurosci, 17: 1392, 1991. 24. Haddad GG and Jiang C. Mechanisms of anoxia-induced depolarization in brainstem neurons: in-vitro

intracellular studies. Soc for Neurosci, 17: 1270, 1991. 25. Jiang C, Cummins TR, and Haddad GG. Voltage-dependent membrane currents in acutely dissociated

brainstem neurons of rats. Soc for Neurosci, 17: 1042, 1991. 26. Friedman JE and Haddad GG. Age-dependent sensitivity to anoxia: Newborn rat hippocampal neurons have a

longer latency and smaller Cai2+ rise than adult. Soc for Neurosci, 17: 184, 1991.

27. Marks JD and Haddad GG. Adenosine A1-receptor activation decreases neuronal excitability in rat brainstem

neurons: In-vitro intracellular studies. Soc for Neurosci, 17: 1548, 1991. 28. Xia Y and Haddad GG. Major differences in CNS KATP channel distribution between rat (newborn, adult) and

turtle. Soc for Neurosci, 17: 64, 1991. 29. Young RSK, During MJ, Haddad GG, Donnelly DF, Aquila WJ, and Perry VL. Effect of anoxia on excitatory

amino acids in brain slices of rats and turtles: In vitro microdialysis study. Soc for Neurosci, 17: 1271, 1991. 30. Young RSK, During MJ, Marks J, Donnelly DF, Aquila W, and Haddad GG. Anoxia increases concentrations of

excitatory amino acids in brain slices of adult but not neonatal rats: in-vitro microdialysis study. Soc Pediatr Res, 31: 356, 1992.

31. Jiang C and Haddad GG. Effects of O2 and glucose deprivation on human and rat neocortical neurons in-vitro.

Soc for Neurosci, 18: 1584, 1992. 32. Hayashi F, Jiang C, Takeda R, and Haddad GG. Mechanisms of CO2 induced depolarization in snail Lymnaea

Stagnalis giant neurons. Soc for Neurosci, 18: 828, 1992. 33. Friedman JE and Haddad GG. Sodium regulates anoxia-induced intracellular calcium changes in CA1

hippocampal neurons. Soc for Neurosci, 18: 1267, 1992. 34. Cummins TR, Xia Y, and Haddad GG. Comparison of the functional properties of human and rat neocortical

sodium currents. Soc for Neurosci, 18: 1136, 1992. 35. Xia Y and Haddad GG. Neuroanatomical Distribution and binding characteristics of saxitoxin sites in the rat

and turtle CNS. Soc for Neurosci, 18: 1134, 1992. 36. Marks JD, Donnelly DF, and Haddad GG. Mechanisms of adenosine a, receptor-mediated effects on cellular

properties in rat vagal motoneurons. Soc for Neurosci, 18: 998, 1992. 37. Haddad GG, Cummins TR, and Jiang C. Anoxia decreases human temporal neuronal excitability by sodium

channel modulation. Soc for Neurosci, 18: 1580, 1992.

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38. Haddad GG, Cummins TR, and Xia Y. Role of Na+ current and transport during anoxia: Developmental aspects.

The Wellcome Trust - Hypoxia Meeting, pg. 67, 1992. 39. Jiang C, Sigworth F, and Haddad GG. Single channel properties of an ATP- and Ca++- sensitive K+ channel in

the rat substantia nigra. Biophysical Soc, 64: A311, 1993. 40. Jiang C and Haddad GG. Hypoxia activates a K+ current in rat central neurons. Soc Pediatr Res, 33(4): 372A,

1993. 41. Friedman JE and Haddad GG. Developmental neuronal sensitivity to anoxia: Role of extra-cellular calcium and

sodium. Soc Pediatr Res, 33(4): 48A, 1993. 42. Xia Y and Haddad GG. Development and distribution of voltage-sensitive sodium channels in the rat CNS. Soc

Pediatr Res, 33(4): 61A, 1993. 43. Cummins TR, Levy DA, and Haddad GG. Effect of anoxia on intracellular pH in isolated newborn and mature

rat hippocampal CA1 neurons. Soc for Neurosci, 19: 1640, 1993. 44. Jiang C and Haddad GG. ATP-Sensitive K+ (KATP) are present in human neocortical neurons. Soc for Neurosci,

19: 706, 1993. 45. Xia Y, Warshaw JB, and Haddad GG. Chronic hypoxia causes down-regulation of glucose transporter I mRNA

in adult but not in fetal rat brain. Soc for Neurosci, 19: 1658, 1993. 46. Krishnan SN, Desai T, Wyman RJ, and Haddad GG. Cloning of a glutamate transporter from human brain. Soc

for Neurosci, 19: 219, 1993. 47. Haddad GG, Desai T, and Krishnan SN. Cloning of a novel human brain ion channel highly similar to KATP

channel in rat kidney. Soc for Neurosci, 19: 1061, 1993. 48. O'Reilly JP, Jiang C, and Haddad GG. Different responses of brainstem and cortical neurons to graded

hypoxia. Soc for Neurosci, 19: 1666, 1993. 49. Friedman JE and Haddad GG. Anoxia induces an increase in intracellular sodium in primary neocortical

neuronal cultures. Soc for Neurosci, 19: 850, 1993. 50. Jiang C and Haddad GG. Hypoxia activates an ATP- and Ca++- sensitive K+ channel in central neurons. IUPS,

201, 1993. 51. Haddad GG and Jiang C. Brain Hypoxia: Ion channel mechanisms and neuronal survival. IUPS, 149, 1993. 52. Friedman JE and Haddad GG. Anoxia increases intracellular sodium in neurons. Am J Respir Crit Care,

149(4): A924, 1994. 53. Krishnan SN, Jiang C, and Haddad GG. Brain Hypoxia: Role and molecular characterization of ATP-sensitive

potassium channels in neuronal membranes. Am J Respir Crit Care, 149(4): A257, 1994. 54. Krishnan SN, Narayan D, Dolan TF, and Haddad GG. Unusual inheritance of primary ciliary dyskinesia. Am J

Respir Crit Care, 149(4): A375, 1994. 55. Marks JD and Haddad GG. Is neonatal neuronal resistance to anoxia due to decreased glutamate sensitivity?

Am J Respir Crit Care, 149(4): A923, 1994. 56. O'Reilly JP and Haddad GG. Increased neuronal sensitivity to acute hypoxia in rats after long-term exposure to

a reduced oxygen environment. Am J Respir Crit Care, 149(4): A256, 1994.

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57. Xia Y, Krishnan SN, Warshaw JB, and Haddad GG. Effect of chronic hypoxia on mRNA expression of glucose

transporter I and III in rat brain. Am J Respir Crit Care, 149(4): A257, 1994. 58. Haddad GG and Jiang C. Adenosine activates a glibenclamide-sensitive K+ current in postsynaptic neurons.

Soc for Neurosci, 20: 725, 1994. 59. O'Reilly JP and Haddad GG. Increased neuronal sensitivity to acute hypoxia in rats after long-term exposure to

a reduced oxygen environment. Soc for Neurosci, 20: 1039, 1994. 60. Friedman JE, Helenius I, and Haddad GG. Anoxia causes cleavage and rearrangement of cyto-skeletal proteins

in rat cortical neurons. Soc for Neurosci, 20: 1039, 1994. 61. Jiang C and Haddad GG. Do K+ channels interact with metal-containing proteins in neuronal membranes to

sense low PO2? Soc for Neurosci, 20: 722, 1994. 62. Xia Y and Haddad GG. Chronic hypoxia modulates the expression of voltage-sensitive Na+ channels in the

developing rat brainstem. Soc for Neurosci, 20: 65, 1994. 63. Marks JD and Haddad GG. Neonatal CA1 neurons do not respond to glutamate concentrations that kill adult

neurons: Time-lapse confocal studies in vitro. Soc for Neurosci, 20: 268, 1994. 64. Xia Y, Warshaw JB, and Haddad GG. Effect of chronic hypoxia on glucose transporter mRNAs in brain, heart

and skeletal muscle in developing rats. Am J Respir Crit Care, 151(4): A634, 1995. 65. O'Reilly JP and Haddad GG. Different responses of cortical and brainstem neurons to graded hypoxia. Am J

Respir Crit Care, 151(4): A633, 1995. 66. Krishnan SN, Mohsenin A, and Haddad GG. Drosophila melanogaster survive prolonged periods of anoxia.

Am J Respir Crit Care, 151(4): A410, 1995. 67. Jiang C and Haddad GG. Characterization of three distinct K+ currents modulated by ATP in human

neocortical neurons. Soc for Neurosci, 21: 1825, 1995. 68. Ma E and Haddad GG. Regulation of gene expression by O2 deprivation in Drosophila melanogaster. Soc for

Neurosci, 21: 1728, 1995. 69. O'Reilly JP and Haddad GG. Chronic hypoxia increases the neuronal response to acute hypoxic stress. Soc for

Neurosci, 21: 1729, 1995. 70. Schwartz ML, O'Reilly JP and Haddad GG. Altered neuronal properties in neocortex following long-term

exposure to hypoxia. Soc for Neurosci, 21: 1729, 1995. 71. Xia Y and Haddad GG. Prolonged O2 deprivation alters Na+ channel mRNA level in excitable tissues in the

developing rat. Soc for Neurosci, 21: 1815, 1995. 72. Friedman JE, Chidekel AS, Chow EJ and Haddad GG. Differential effects of anoxia and glutamate on cultured

cortical neurons. Soc for Neurosci, 21: 217, 1995. 73. Chidekel AS, Friedman JE and Haddad GG. The role of extracellular sodium in anoxia-induced injury in rat

neocortical neuronal culture. Soc for Neurosci, 21: 218, 1995. 74. Novotny EJ, Ariyan C, Akiyama J, O'Reilly J, Behar KL and Haddad GG. Comparison of the ontogeny of brain

oxidative metabolism in vivo vs. in vitro: An NMR spectroscopy study. Soc for Neurosci, 21: 1668, 1995. 75. O'Reilly J, Schwartz ML and Haddad GG. Adaptive mechanisms in developing brain: II. Effect of chronic

hypoxia on neuronal excitability. Ann Neurol, 38: 533-534, 1995.

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76. Ment LR, Haddad GG, Madri JA, Novotny EJ, Schwartz ML, Stewart WB. Adaptive mechanisms in developing

brain: J Neuropathology. Ann Neurol, 38: 521, 1995. 77. Chidekel AS, Chow EJ, Friedman JE and Haddad GG. The role of Na+-dependent exchangers in hypoxia-

induced injury in rat neocortical neuronal culture. Am J Respir Crit Care, 153(4): A 639, 1996. 78. Banasiak KJ and Haddad GG. Hypoxia induces apoptosis in cultured rat neocortical neurons. Am J Respir Crit

Care, 153(4): A639, 1996. 79. Xia Y and Haddad GG. Glucose transporter mRNA expression in rat diaphragm, heart and limb skeletal

muscles: Temporal pattern during chronic O2 deprivation. Am J Respir Crit Care, 153(4): A116, 1996. 80. Xia Y, O'Reilly JP and Haddad GG. Prolonged hypoxia increases in Na+ channel density in cultured rat

neocortical neurons. Soc for Neurosci, 22: 2151, 1996. 81. Banasiak K, Bazzy-Asaad, AR and Haddad GG. Apoptosis depends on severity and duration of hypoxia in

cultured neocortical neurons. Soc for Neurosci, 22: 1480, 1996. 82. Ma E and Haddad GG. Anoxia resistance in Drosophila melanogaster: Gene regulation as molecular basis. Soc

for Neurosci, 22: 2081, 1996. 83. O'Reilly JP and Haddad GG. Hypoxia reduces Na+ current in hippocampal neurons via a kinase mediated

pathway. Soc for Neurosci, 22: 2151, 1996. 84. Fung M-L and Haddad GG. Effect of amiloride and its derivatives on the electrical properties of hippocampal

CA1 neurons at rest and during anoxia. Soc for Neurosci, 22: 2151, 1996. 85. Haddad GG, Sun Y and Xu T. Genetic determination of anoxic tolerance in Drosophila melanogaster flies.

Drosophila Res Conf, presented Chicago, IL, April 1997. 86. Ma E, Xu T and Haddad GG. A molecular study of O2 deprivation resistance in Drosophila melanogaster.

Drosophila Res Conf, presented Chicago, IL, April, 1997. 87. Haddad GG and Xu T. Genetic determination of anoxic tolerance in Drosophila melanogaster flies. Am J

Respir Crit Care, 155(4): A444, 1997. 88. Banasiak K and Haddad GG. Bcl-2 and p53 are increased in hypoxia-induced neuronal apoptosis. Am J Respir

Crit Care, 155(4): A94, 1997. 89. Behar KL, Ariyan C, Mason GF, Haddad GG and Novotny EJ. Determination of the rates of glucose utilization

and the tricarboxylic acid cycle from [1-13C] glucose in the developing rat brain. Perinatal Cerebral Blood Flow & Metabolism Conf, presented Hershey, PA, June, 1997.

90. Haddad GG, Sun Y, Wyman R and Xu T. Genetic basis of anoxia tolerance in Drosophila melanogaster. Soc for

Neurosci, 23: 1391, 1997. 91. Banasiak K, Bazzy-Asaad A and Haddad GG. P53 Mediates Hypoxia-Induced Neuronal Apoptosis. Soc for

Neurosci, 23: 2254, 1997. 92. Douglas RM, Xia Y, Biemesderfer D and Haddad GG. Modulation of the sodium hydrogen exchanger: Effect of

Development and Hypoxic Stress. Soc for Neurosci, 23: 137, 1997. 93. Xia Y, Fung ML, O'Reilly JP and Haddad GG. Prolonged exposure to low O2 increases neuronal excitability via

Na+ channel up-regulation. Soc for Neurosci, 23: 544, 1997.

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94. Zhang P, Moczydlowski and Haddad GG. Modulation of calcium-activated potassium channels in excised patches by low oxygen. Soc for Neurosci, 23: 1746, 1997.

95. Jiang C, Zhu GY, Hayashi and Haddad GG. Inhibition of K+ currents by CO2 in snail Lymnaea Stagnalis

neuron. Soc for Neurosci, 23: 433, 1997. 96. Xia Y, Douglas RM, Rothstein JD and Haddad GG. Effects of development and hypoxia on glutamate

transporters in rat brains. Exp Biol, 12(5): A754-4372, 1998. 97. Douglas RM, Ma E, Xu T and Haddad GG. Genetic basis of hypoxia/anoxia tolerance in Drosophila

melanogaster. Exp Biol, 12(5): A755-4375, 1998. 98. Banasiak K and Haddad GG. Influence of bel-2 and p53 on neuronal survival during hypoxia-induced neuronal

apoptosis. APS/SPR, 43(4) 34A, 1998. 99. Xia Y, Kellser JL and Haddad GG. Prolonged O2 deprivation down-regulated glucose transporter-3 in adult but

not in immature rat brain. Am J Respir Crit Care, 157(3): A249, 1998. 100. Schmitt BM, Bevensee MO, Douglas R, Berger UV, Hediger MA, Haddad GG and Boron WF. Expression and

localization of Na/HCO3 cotransporter (NBC) mRNA and protein in adult rat brain. Soc for Neurosci, 24: 1066, 1998.

101. Douglas RM, Xia Y, Schmitt BM, Bevensee MO, Biemesderfer D, Boron WF and Haddad GG. Developmental

and stress-induced profile of two CNS pH regulatory proteins: The Na/H exchanger and the Na/HCO3 cotransporter. Soc for Neurosci, 24: 1605, 1998.

102. Ma E and Haddad GG. Cloning and genetic analysis of Drosophila melanogaster HIFIß homolog, a hypoxia-

regulated transcription factor. Soc for Neurosci, 24: 222, 1998. 103. Gu XQ and Haddad GG. Effects of hypoxia on embryonic Drosophila neurons in culture. Soc for Neurosci, 24:

1822, 1998. 104. Yao H, Ma E, Barnstable CJ and Haddad GG. PH regulation of CA1 neurons isolated from NHE-1 Null mice.

Soc for Neurosci, 24: 1605, 1998. 105. Xia Y, Douglas RM, Rothstein JD and Haddad GG. Differential effects of chronic hypoxia on neuronal and

astrocytic glutamate transporters in developing rat brains. Soc for Neurosci, 24: 2066, 1998. 106. Xia Y, Gibney G, Douglas RM and Haddad GG. Effects of development and chronic hypoxia on the expression

of Na+/Ca++ exchanger in rat brains. Mol Biol Cell, 9: 77A, 1998. 107. Ma E and Haddad GG. Anoxia tolerance/Susceptibility in Drosophila as a model organism. Am Heart Assoc,

The Genome Program: Applications to Cardiovascular Biology, San Diego, CA.. pg. 61, 1998. 108. Xia Y, Gibney G, Garcia RE, Douglas RM and Haddad GG. A rat chronic hypoxia model: Differential

responses of various organs to oxygen (O2) deprivation. Am J Respir Crit Care, 159(3): A842, 1999. 109. Haddad GG, Ma E, Douglas RM and Xu T. Tolerance to O2 deprivation: Genetic basis using a Drosophila

model system. Pediatric Res 45(4): 342A, 1999. 110. Banasiak KJ and Haddad GG. Importance of sodium homeostasis during hypoxia-induced apoptosis. Pediatric

Res 45(4): 339A, 1999. 111. Huffard BH, Douglas RM, Haddad GG. The effect of oxygen deprivation on the cell cycle of Drosophila

melanogaster embryos. Pediatric Res, 45(4): 53A, 1999.

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112. Haddad GG, Zhang JH, Bazzy AR and Xia Y. Chronic hypoxia differentially regulates ä-opiod receptor expression in adult and immature brains. Soc for Neurosci, 25: 579, 1999.

113. Xia Y and Haddad GG. Major differences in δ-opioid receptor density and binding affinity between turtle and

rat brains. Soc for Neurosci, 25: 579, 1999. 114. Ma E, Douglas RM and Haddad GG. A role of Drosophila melanogaster CDK5α-like molecule in hypoxia. Soc

for Neurosci, 25: 826, 1999. 115. Zhang JH, Xia Y and Haddad GG. Activation of δ-opioid receptors protects cortical neurons from glutamate

excitotoxic injury. Soc for Neurosci, 25: 579, 1999. 116. Gu XQ, Yao H and Haddad GG. Effect of hypoxia on neurons devoid of Na/H Isoform 1. Soc for Neurosci, 25:

728, 1999. 117. Liu H, Moczydlowski E and Haddad GG. O2 deprivation inhibits Ca2+-Activated K+ channels via cytosolic

factors in mice neocortical neurons. Soc for Neurosci, 25: 1728, 1999. 118. Yao H, Douglas RM and Haddad GG. NHE-1 null neurons have abnormally low HCO3

—dependent acid extrusion mechanisms. Soc for Neurosci, 25: 2209, 1999.

119. Banasiak KJ, Donnelly D and Haddad GG. Sodium flux during hypoxia-induced neuronal apoptosis. Soc for

Neurosci, 25: 754, 1999. 120. Douglas RM, Lim JY, Yao H and Haddad GG. The expression of sodium-hydrogen exchangers and bicarbonate-

dependent transporters in the brain of NHE1 null mutant mice. Soc for Neurosci, 26: 1671, 2000. 121. Gu XQ, Yao H and Haddad GG. Effect of extracellular HCO3

-/CO2 on Na+ channel characteristics in hippocampal CA1 neurons. Soc for Neurosci, 26: 1905, 2000.

122. Yao H, Gu XQ and Haddad GG. Anoxia affects the pH regulation in mouse CA1 neurons. Soc for Neurosci, 26:

1671, 2000. 123. Gibney G, Zhang JH, Haddad GG and Xia Y. Effect of development and hypoxia on Na+ channel mRNA

subtypes in rat cortex. Soc for Neurosci, 26: 502, 2000. 124. Zhang JH, Haddad GG and Xia Y. δ-Opioid receptor expression is differentially regulated in cortical neurons

depending on hypoxic duration. Soc for Neurosci, 26: 772, 2000. 125. Banasiak K, Burenkova O and Haddad GG. Sodium influx during hypoxia induces neuronal apoptosis via

activation of Caspase-3. Soc for Neurosci, 26: 1880, 2000. 126. Ma E, Xu T and Haddad GG. Pre-mRNA editase and its role in cell tolerance to O2 deprivation in Drosophila

melanogaster. Mol Biol Cell, 11: 63, 2000. 127. Douglas RM, Xu T and Haddad GG. Effect of O2 deprivation on cell cycle checkpoint protein expression in

Drosophila melanogaster. Mol Biol Cell, 11: 179, 2000. 128. Vicencio AG, Eickelberg O, Reyes-Mugica M, Kashgarian M, Haddad GG. Divergent regulation of TGF-β

Receptor Type I and II in response to hypoxia. Am J Respir Crit Care, 163(5): A94, 2001. 129. Eickelberg O, Vicencio, AG, Ryu J, Kashgarian M and Haddad GG. Differential effect of hypoxia on MMP-2,

MMP-9 and TIMP-1 expression in rat lungs. Am J Respir Crit Care, 163(5): A232, 2001. 130. Douglas RM, Chen JY and Haddad GG. The effect of intermittent hypoxia on the expression of acid-base

transporters in the mouse central nervous system. Soc for Neuroscience, 27: 447, 2001.

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131. Kass LJ, Kennan RP, Haddad GG and Novotny EJ. Moderate to severe obstructive sleep apnea in children

causes alterations in regional cerebral blood flow during sleep. Soc for Neuroscience, 27: 435, 2001. 132. Xia Y, Cao H, Zhang J, Chen NY, Siegel K, Agulnik M and Haddad GG. Effect of δ- opioid receptor activation

on Na+ channel expression in cortical neurons subjected to prolonged hypoxia in culture. Soc for Neuroscience, 27: 381, 2001.

133. Gu XQ and Haddad GG. Decreased excitability in hippocampal neurons of mice exposed to intermittent

hypoxia. Soc for Neuroscience, 27: 367, 2001. 134. Banasiak KJ, Burenkova O and Haddad GG. Activation of voltage-sensitive sodium channels induces caspase-

3-mediated neuronal apoptosis. Soc for Neuroscience, 27: 501, 2001. 135. Malthankar GV, White BK, Lai JCK, Behar KL and Haddad GG. Cyclic hypoxia induces selective changes in

activities of certain energy-metabolizing enzymes in mouse brain. Soc for Neuroscience, 27: 447, 2001. 136. Eickelberg O, Vicencio AG, Haddad GG, Siegel NJ and Kashgarian M. Differential expression of Smads and

TGF-B receptors during postnatal kidney development. ASN/ISN World Congress of Nephrology, 2001. 137. Xiao Y-Y, White KP and Haddad GG. Gene expression profiling in response to O2 deprivation in the central

nervous system of Drosophila melanogaster. The Genetics Society of America (GSA), 2001. 138. Douglas RM, Xu T and Haddad GG. Hypoxia induces differential effects on cell cycle kinetics and protein

expression. The Genetics Society of America (GSA), 2001. 139. Chen Q-F, Ma E, Behar KL, Xu T and Haddad GG. Role of trehalose phosphate synthase in anoxia tolerance

and development in Drosophila melanogaster. The Genetics Society of America (GSA), 2001. 140. Farahani R, Douglas RM, Gibney G, Xu T and Haddad GG. Searching for genes conferring anoxia tolerance in

Drosophila melanogaster. The Genetics Society of America (GSA), 2001. 141. Sun X and Haddad GG. Calcium influx vial L- and N-type calcium channels activate a fast transient BK current

in mice neocortical pyramidal neurons. Society for Neuroscience, 2002. 142. Douglas RM, Lai JCK, Behar KL and Haddad GG. Voltage-sensitive Na+ channels are present in mitochondria

of rat brain cells. Society for Neuroscience, 2002. 143. Xia S, Douglas RM, Lai JCK, Behar KL, Moczydlowski and Haddad GG. BSLO is present in mitochondria and

may have a role in neuronal apoptosis. Society for Neuroscience, 2002. 144. Gu XQ and Haddad GG. Maturation of neuronal excitability in hippocampal neurons of mice exposed to cyclic

hypoxia. Society for Neuroscience, 2002. 145. Xue J, Douglas RM and Haddad GG. Effects of NHE1 null mutation on the expression of acid-base transporters

and the voltage-sensitive Na+ channel in mouse brain. Society for Neuroscience, 2002. 146. Zhou D and Haddad GG. Gene expression in response to long-term hypoxic environment in Drosophila

Melanogaster. The Genetics Society of America (GSA), 2003. 147. Douglas RM and Haddad GG. Severe hypoxia induces stabilization of cyclin A and increased expression of

E2F2 which may contribute to a metaphase and an interphase arrest, respectively. The Genetics Society of America (GSA), 2003.

148. Xue J, Zhao P, Gu XG, Xia Y and Haddad GG. Intermittent hypoxia modulates sodium channel expression in

developing mouse brain. Experimental Biology, Translating the Genome, 2003.

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149. Gu XQ, Xue J and Haddad GG. Early and late development of hippocampal neurons of mice exposed to chronic

cyclic hypoxia. Experimental Biology, Translating the Genome, 2003. 150. Douglas RM, Xue J and Haddad GG. Chronic intermittent hypoxia decreases the expression of specific acid-

base transporters in the mouse CNS. Experimental Biology, Translating the Genome, 2003. 151. Esquibies AE, Farahani R and Haddad GG. Intermittent hypoxia down-regulates the expression of

prostaglandin D2 synthase in mouse brain. Society for Neuroscience, 2003. 152. Douglas RM, Lai JCK, Moczydlowski E and Haddad GG. The calcium-sensitive potassium channel (BK/Maxi

K) is present in the mitochondria of rat brain. Society for Neuroscience, 2003. 153. Zhou D, Xue J, Bradley C and Haddad GG. Altered gene expression profile in different brain regions of NHE-1

null mutant mice determined by cDNA microarrays. Society for Neuroscience, 2003. 154. Sun X, Kaczmarek LK and Haddad GG. Effects of hypoxia on Ca2+ and K+ currents in mouse neocortical

pyramidal neurons. Society for Neuroscience, 2003. 155. Morcillo P. Farahani R, Douglas RM and Haddad GG. Viable P-element screen for genes conferring anoxia

tolerance in Drosophila melanogaster. Presented, Genetics Society of America (GSA), 2004. 156. Zhou D, Lambert D, Huang H, Morgan NC, Lu-Bo Y, Xue J, Douglas RM, Xu T, White KP and Haddad GG.

Presented, Genetics Society of America (GSA), 2004. 157. Farahani R, Morcillo P, Douglas RM and Haddad GG. Mapping two mutations to X12A-E conferring anoxia

sensitivity in Drosophila melanogaster. Presented, Genetics Society of America (GSA), 2004. 158. Gu XQ and Haddad GG. Characteristics of Na+ channel of hippocampal neurons of mice chronically exposed to

elevated CO2 environment. Presented, Experimental Biology, 2004. 159. Douglas RM and Haddad GG. Embryonic cell cycle activity and protein expression are modulated by changes

in oxygen concentration. Presented, Experimental Biology, 2004. 160. Morcillo P. Farahani R, Douglas RM and Haddad GG. Viable P-element screen for genes conferring anoxia

tolerance in Drosophila melanogaster. Presented, Experimental Biology, 2004. 161. Fan C, Iacobas DA, Zhou D, Chen QF and Haddad GG. Gene expression changes in hearts of mice subjected to

chronic hypoxia. Presented, Experimental Biology, 2004. 162. Chen QF, Behar KL, Xu T, Fan C and Haddad GG. Expression of Drosophila trehalose phosphate synthase

increases hypoxia tolerance in Drosophila and HEK-293 cells. Presented, Experimental Biology, 2004. 163. Zhou D, Xue J, Gavrialov and Haddad GG. Na+/H+ exchanger 1 regulates gene expression in mouse brain.

Presented, Experimental Biology, 2004. 164. Morcillo P, Farahani R, Douglas R, Zhou D and Haddad GG. A P-element screen for genes conferring hypoxia

tolerance and sensitivity in Drosophila melanogaster. Presented, The Genetics Society of America (GSA – 951C), 2005.

165. Zhou D, Morcillo P, Xue J, Morgan N, Lu-Bo Y, Gavrialov O, Haddad C and Haddad GG. Phenotypic changes

in long-term hyperoxia-selected Drosophila melanogaster. Presented, The Genetics Society of America (GSA – 959B), 2005.

166. Vicencio AG, Lee C, Eickelberg O, Chuu Y, Haddad GG and Elias JA. Overexpression of bioactive TGF-beta 1

in neonatal mouse lung: A new model for BPD? Presented, Pediatric Academic Societies, 2004.

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167. Ryu J and Haddad GG. The effect of hypoxia on matrix metalloproteinase system in immature vs. mature mouse

lungs. Presented, American Thoracic Society, 2004. 168. Vicencio AF, Gavrialov O, Zhou D and Haddad GG. Hypoxia-induced delayed alveolarization: A new model to

investigate alveolar development? Presented, American Thoracic Society, 2004. 169. Kanaan A, Douglas RM, Farahani R, LaManna JC and Haddad GG. Effect of chronic continuous or

intermittent hypoxia and chronic hypercapnia on cerebral vascularity. Submitted, Society for Neuroscience, 2004.

170. Li GY, Xue J, Zhou D, Douglas RM, Gavrialov O and Haddad GG. Expression pattern of protein kinase C

isoforms in the mouse central nervous system under hypoxia. Submitted, Society for Neuroscience, 2004. 171. Farahani R, Esquibies AE and Haddad GG. Effect of hypoxia on prostaglandin D2 synthase in mouse brain and

heart. Submitted, Society for Neuroscience, 2004. 172. Sun X, Zhou D, Moczydlowski EG and Haddad GG. Arachidonic acid enhances a Slo BK current by altering

alpha and beta subunit interactions. Submitted, Society for Neuroscience, 2004. 173. Yao H, Xue J and Haddad GG. Propagation of cell death with ischemia – An in vitro model for the study of cell

death mechanisms. Submitted, Society for Neuroscience, 2004. 174. Scafidi S, Haddad GG and Banasiak KJ. Brain prostaglandin transporter expression during development and

hypoxia. Submitted, Society for Neuroscience, 2004. 175. Farahani R, Kanaan A, Douglas RM, Gavrialov O and Haddad GG. Phenotypic characterization of the

mouse model of post-natal hypoxia. Presented, Experimental Biology, 2005. 176. Zhou D, White KP, Morcillo P and Haddad GG. Exploring the genetic basis of hypoxia tolerance in Drosophila

melanogaster. Presented, Experimental Biology, 2005. 177. Zhou D, Xue J, Haddad CG, White KP and Haddad GG. Gene expression profiles at different developmental

stages in naïve and hypoxia- selected Drosophila melanogaster. Presented, Experimental Biology, 2005. 178. Sun X, Zhou D and Haddad GG. Arachidonic acid enhances a Slo BK current by altering beta subunit

modulation. Presented, Experimental Biology, 2005. 179. Xue J, Zhou D, Li GY, Gavrialov O and Haddad GG. Role of transporters in hypoxic injury in cultured cortical

neurons. Presented, Experimental Biology, 2005. 180. Li GY, Zhou D, Xue J, Vicencio A, Gavrialov O and Haddad GG. CO2-Induced changes in gene expression of

mouse brain and lung. Presented, Experimental Biology, 2005. 181. Gu XQ and Haddad GG. Decreased excitability of hippocampal neurons of mice chronically exposed to

elevated CO2 environment. Presented, Experimental Biology, 2005. 182. Yao H, Gu XQ and Haddad GG. DIDS induces a bigger acidification in CA1 neurons isolated from mice

chronically exposed to high CO2. Presented, Experimental Biology, 2005. 183. Morcillo P, Farahani R, Douglas R, Zhou D and Haddad GG. A P-element screen for genes conferring

hypoxia tolerance and sensitivity in Drosophila melanogaster. Presented, Genetics Society of America (GSA), 2005.

184. Zhou D, Morcillo P, Xue J, Morgan N, Lu-Bo Y, Gavrialov O, Haddad CG and Haddad GG. Phenotypic

changes in long-term hyperoxia-selected Drosophila melanogaster. Presented, Genetics Society of America

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(GSA), 2005. 185. Xue J, Zhou D, Yao H, McConnell MJ, Gelb BD, and Haddad GG. Novel Functional Interaction between

Na+/H+ Exchanger 1 and Tyrosine Phosphatase SHP-2. Presented, Cell Biology 2005. 186. Zhou D, Xue J, Morcillo P, Lambert JD, Huang H, White KP, Haddad GG. Genetic Basis of Hypoxia

Tolerance in Drosophila melanogaster. Presented, Genetics Society of America (GSA), 2006. 187. Gu X, Yao H, and Haddad GG. Effects of chronically elevated CO2 on excitability of mice hippocampal

neurons. Presented, Experimental Biology, 2006. 188. Kanaan A, Douglas RM, Kelly ML, Boron W and Haddad GG. The Effect of Chronic Hypercapnia on the

Expression of Acid-Base Transporters in the Neonatal and Adult Mouse. Presented, Society for Neuroscience, 2006.

189. Gu XQ, Yao H and Haddad GG. Effects of chronically elevated CO2 on the development of neuronal

excitability in mouse hippocampus. Presented, Society for Neuroscience, 2006. 190. Sun X, Zhou D and Haddad GG. β-subunit-dependent modulation of hslo BK current by arachidonic acid.

Presented, Society for Neuroscience, 2006. 191. Ruffin VA, Gu X, Zhou D, Douglas RM, Trouth CO and Haddad GG. The sodium-activated potassium

channel Slack (Slo 2.2) is modulated by hypercapnia and acidosis. Presented, Society for Neuroscience, 2006.

192. Yao H, Gu X, Wang J and Haddad GG. Ion shifts and cell death in an in vitro ischemia model. Presented,

Society for Neuroscience, 2006. 193. Douglas RM, Miyasaka N, Takahash K, Latuszek-Barrantes A and Haddad GG, Hetherington, HP. Chronic

intermittent but not constant hypoxia decreases NAA/Cr ratios in mouse hippocampus. Presented, Society for Neuroscience, 2006.

194. Ryu J, Sukkarieh M, Heldt GP, Gavrialov O and Haddad GG. Effect of chronic hypercapnia on lung

development. American Thoracic Society, 2006. 195. Vicencio AG, Du Z and Haddad GG. Chronic hypercapnia attenuates hyperoxia-induced fibrosis in the

neonatal mouse. Presented, American Thoracic Society, 2006. 196. Zhou D, Xue J, White KP and Haddad GG. Long-Term Hypoxia-Selected Drosophila melanogaster: A New

Approach for Studying Mechanisms of Hypoxia-Tolerance. Presented, 5th Lung Science Conference, 2007. 197. Xue J, Zhou D, Al S, Zhao HW, Dugan L and Haddad GG. Long-Term Hyperoxia-Selected Drosophila

melanogaster: A New Approach for Studying Tolerance to Oxidative Stress. Presented, 5th Lung Science Conference, 2007.

198. Ryu J, Gavrialov O and Haddad GG. Impact of hypercapnia on lung maturation. Presented, 5th Lung Science

Conference, 2007. 199. Zhou D, Xue J, Ali S, Zhao HW, Dugan L and Haddad GG. Phenotypic changes and gene expression profile

in hyperoxia-selected Drosophila melanogaster. Presented, Experimental Biology, 2007. 200. Zhou D, Xue J and Haddad GG. Mechanism of Metabolic Suppression in Hypoxia-Selected Drosophila

melanogaster. Presented, Experimental Biology, 2007. 201. Kanaan A, Douglas RM, Kelly ML, Alper SL, Boron WF and Haddad GG. The expression of acid-base

transporters in the neonatal and adult mouse exposed to chronic hypercapnia. Presented, Experimental

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Biology, 2007. 202. Gu XQ, Kanaan A, Yao H and Haddad GG. Chronic high inspired CO2 decreases excitability of mouse

hippocampal neurons. Presented, Experimental Biology, 2007. 203. Zhao H, Zhou D and Haddad GG. Genetic basis of hyperoxia tolerance in Drosophila melanogaster larvae.

Presented, Experimental Biology, 2007. 204. Ryu J, Sukkarieh M, Heldt GP, Gavrialov O, and Haddad GG. Effect of chronic hypercapnia on lung

development. Presented, American Thoracic Society, 2007. 205. Zhou D, Wang J, Zapala MA, Xue J, Schork N and Haddad GG. Expression profiles following chronic

constant or chronic intermittent hypoxia in mouse brain: role of Sspn in cell death under hypoxia. Society for Neuroscience, 2007.

206. Yao H, Sun X, Gu X, Wang J and Haddad GG. Cell death in the ischemic infarct rim. Society for

Neuroscience, 2007. 207. Douglas RM, Kanaan A, Reynolds SA and Haddad GG. Combined Intermittent Hypoxia/Hypercapnia

Induces Oxidant Cell Death In The Mouse CNS. Society for Neuroscience, 2007. 208. Cheng Y, Gu X, Bednarczyk P, Zhao H, Haddad GG and D. Siemen D. Hypoxia modifies mitochondrial BK-

channels of astrocyte-cell line. Society for Neuroscience, 2007. 209. Gu XQ, Yao H, Sun X and Haddad GG. Gating properties of mice hippocampal neuronal Na+ channel

chronically exposed to higher CO2 environment. Society for Neuroscience, 2007. 210. Sun X, Yao H, Zhou D, Gu X and Haddad GG. Modulation of hSlo BK current inactivation by fatty acid

esters. Society for Neuroscience, 2007. 211. Dan Zhou, Jin Xue, Orit Gavrialov, Haddad GG. Mechanism of metabolic suppression in Drosophila

melanogaster surviving extremely low O2 environments. 49th Annual Drosophila Research Conference, Genetic Society of America, San Diego, CA., 2008.

212. Azad P, Zhou D, Haddad GG. Gene expression analysis of Drosophila melanogaster after acute and short

intermittent and constant hypoxia treatment. 49th Annual Drosophila Research Conference, Genetic Society of America, San Diego, CA., 2008.

213. Visk DW, Zhou D, Haddad GG. Over-expression of the Notch intracellular domain in neural cells potentiates

long-term surviving of Drosophila in hypoxia. 49th Annual Drosophila Research Conference, Genetic Society of America, San Diego, CA., 2008.

214. Zhao HW, Zhou D, Haddad GG. Laboratory selection for hyperoxia-tolerance in Drosophila melanogaster:

Role of single genes in tolerance. 49th Annual Drosophila Research Conference, Genetic Society of America, San Diego, CA., 2008.

215. Yao H, Felfly H, Wang J and Haddad GG. DIDS protects against neuronal injury by blocking Toll-like

receptor 2 activated-mechanisms. Soc Neurosci Abstr. 2008. 216. Sun X, Yao H, Wang J, Haddad GG. Insulin signaling activation protects dentate neurons from oxygen-

glucose deprivation in organotypic hippocampal slicecultures. Experimental Biology Abstract. New Orleans, LA, 2009.

217. Yao H, Wang J, Theodorakis EA, Haddad GG. Isothiocyanate attenuates ischemia-induced cell death.

Experimental Biology Abstract. New Orleans, LA, 2009.

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218. Visk, DW, Zhou D, Haddad GG. Over-Expression of the Notch Intracellular Domain in Glial Cells Potentiates Long-Term Survival of Drosophila in Hypoxia. Drosophila Research Conference, Genetic Society of America, Chicago, IL, 2009.

219. Huang H, Lu-Bo Y, Haddad GG. A Drosophila homologue of human multidrug resistance-associated protein

4 (MRP4), CG14709, is crucial for the viability of Drosophila under hypoxic and oxidative stresses. Drosophila Research Conference, Genetic Society of America, Chicago, IL 2009.

220. Zhou D, Xue J, White KP, Haddad GG. Mechanism of Metabolic suppression in Drosophila melanogaster

under Long-term Hypoxia. Drosophila Research Conference, Genetic Society of America, Chicago, IL 2009. 221. Ryu J, Heldt GP, Nguyen M, Gavrialov O, Haddad GG. Chronic hypercapnia induces collagen degradation

in mice pups. American Thoracic Society abstract. San Diego, CA, 2009.

222. Gu X, Siemen D, Cheng Y, Yao H, Sun X, Haddad, GG. Different mechanisms underlying different effects of hypoxic agents on inner mitochondrial membranes of a glioblastoma cell line. Society for Neuroscience, Chicago, IL 2009.

223. Zhou D, Sameh A, Hsiao M, Xue J, Dugan, L, Haddad, GG. Metabolic Adaptation to Chronic Hypoxia in Drosophila melanogaster. Drosophila Research Conference, Genetic Society of America, Washington DC, 2010.

224. Azad P, Zhou D, Haddad GG. Distinct Mechanisms Underlying Tolerance to Intermittent and Constant

Hypoxia in Drosophila melanogaster. Drosophila Research Conference, Genetic Society of America, Washington DC, 2010.

225. Huang H, Lu-Bo Y, Haddad, GG. The Drosophila homologue of the human multidrug resistance-associated

protein 4 (dMRP4) is a negative regulator of the Imd pathway in hypoxia. Drosophila Research Conference, Genetic Society of America, Washington DC, 2010.

226. Visk D, Haddad GG. Notch Signaling: A Role in Survival of Drosophila during Chronic Hypoxia.

Drosophila Research Conference, Genetic Society of America, Washington DC, 2010.

227. Pamenter ME, Gu X, Yoon M, Perkins GA, Ellisman MH, Haddad GG. 4,4-diisothiocyanatostilbenedisulphonic acid (DIDS) is cytotoxic and does not provide protection against ischemic insults in cultured neurons or astrocytes. Experimental Biology Abstract. Anaheim, CA 2010

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