Future Of Diagnostic Imaging

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(Part 4). ?. Future Of Diagnostic Imaging. A Look Into The Next Decade. PET-CT. Application. New Eye on The Body. Excellent resolution for cancer detection, staging, management Good ChemistrySpecific markers for specific cancers Cardiac and Neuro applications, too - PowerPoint PPT Presentation

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  • Future Of Diagnostic ImagingA Look Into The Next Decade?(Part 4)

  • PET-CTNew Eye on The BodyExcellent resolution for cancer detection, staging, managementGood ChemistrySpecific markers for specific cancersCardiac and Neuro applications, tooProductivity2X Info, 1/2 the timeMedicare Reimbursements ~$1,800~30% AAGR Procedures (+150% in 02)Studies approved Expanding to Diagnosis, Staging, Re-Staging
  • Courtesy of Holy Name HospitalDiscovery ... changed radiation treatment planning in 63% of the patientsDizendorf, Univ. of Zurich: Diagnostic Imaging (Dec. 2001) PET/CT Fusion Proves Its WorthDiscovery improving cancer treatment

  • Human Genome Discovery88-00: Mapped98-10: Analyzing SNPsHuman Proteome Discovery00-20: Discovering Protein Relationships to GenesGenomics Development Targeted ChemistryTargeted chemistry that binds to and highlight biomarkersImaging TechnologiesHigh-sensitivity, high-resolution scannersDisease Biomarkers identified from studies of the Human Genome & ProteomeDetect Life Threatening Disease Before Symptoms AppearEx. ParkinsonsSee Drugs Hitting Their Targets Almost InstantaneouslyDetermine Patient Candidacy for DrugsBring to Market Life Saving Drugs Tailored to Individuals Genetic Make-up FasterPreventive MedicineMolecular Imaging

    Moving to functional imaging, Id like to talk about what I think may actually be our most important discussion today: PET CT. If youre not already familiar with PET and PET CT, let me provide a brief overviewCombined PET and CT is, quite simply, the registration of functional imaging information, from PET, onto an exact anatomical map, with CT. As Im sure you may already know, Positron emission tomography has truly excellent capabilities for detecting cancer, primarily due to very good chemistry, including more and more specific markers for specific diseases. When combined with CT, this imaging technology is truly unmatched in its ability to detect, stage and manage cancer. The outlook for using PET CT is also excellent in cardiology and neurology as wellAnd, overall, the imaging modality is just a very highly productive source of diagnostic information.The economics of PET CT are also solid. Procedures are growing rapidly and more new reimbursements are coming. The key at this time, though, is in expanding physician education and referrals.Id like to make a few comments about molecular medicine, and the role that diagnostic imaging will play in this space. This chart is a flow chartdepicting the overall development and implementation of molecular medicine from one perspective. Its important to note that, in essence, all the parts of this map pre-exist. What is happening today is all about increasing the specificity of direction and speeding up the time in which diseases can be understood and detected and therapies developed. We see big opportunities to add chemistry-based specificity to even existing imaging capabilities and strengths. In short, the value of the imaging device will simply grow and grow over time!First on the upper left part of the pageWe are all aware of how science is evolving, and that the human genome has been sequenced. And many academics and some companies are working to determine what this means for medicine, including diagnostics and therapeutics. Bottom line, we have a HUGE data set today that we previously didnt have.Lower leftAt the biomarker level, that genomics information set is being used to determine the changes in the body that are specific and relevant for diseaseAnd, in particular, funneling that focus down to abnormal functionunderstanding disease presence and progression in a new way, from a genomic levelRATHER than thru the historically more random discovery process. Bottom line, Biomarkers are very specific about disease!Lower centerHere we can now label the biomarkers, injecting chemistry to find and tag the biomarker. This essentially involves adding signal to enable detection. The chemistry space is a huge growth area for molecular imagingindeed, really the limiting factor, or bottle neck, to progress.Lower rightWe can then scan to detect it non-invasively.Upper rightThe result is a big impact on medicine. Example disease: ParkinsonsWhere we know we lose dopamine long before symptoms appear. If one has a history of the disease, we have good reason to perform diagnostics to catch it earlyand, in turn, extend the disease free period.This technology will also be very important for knowing whether treatments are workingEsp. when they are very costly. Some treatments and effects will be asymptomaticBut, we want to know the therapy reached its target and is having an effect. For example, in Alzheimers, if I stop cognitive design, how do I know? Answer: Imaging/chemistry technology can show that the drug got there, AND had an effect that could be measured. Another example is, again, in Parkinsonswhere we could know that the patient is no longer losing function. Again, all of this is especially important where there is a very high cost per dose of therapy.