Funding Opportunities Funding Opportunities at the NIH and the at the NIH and the

National Institute of National Institute of Biomedical Imaging Biomedical Imaging and Bioengineeringand Bioengineering

Grace C.Y. Peng, Ph.D.March 19, 2009

1st annual ORNL Biomedical Science1st annual ORNL Biomedical Scienceand Engineering Conferenceand Engineering Conference

= Institutes and Centers that award grants

Elias Zerhouni, M.D.Director, NIH

Elias Zerhouni, M.D.Director, NIH

National Instituteon Alcohol Abuseand Alcoholism

National Instituteon Alcohol Abuseand Alcoholism

National Instituteof Arthritis andMusculoskeletal

and Skin Diseases

National Instituteof Arthritis andMusculoskeletal

and Skin Diseases

National CancerInstitute

National CancerInstitute

National Instituteof Diabetes andDigestive and

Kidney Diseases

National Instituteof Diabetes andDigestive and

Kidney Diseases

National Instituteof Dental andCraniofacial

Research

National Instituteof Dental andCraniofacial

Research

National Instituteon Drug Abuse

National Instituteon Drug Abuse

National Instituteof Environmental Health Sciences

National Instituteof Environmental Health Sciences

National Instituteon Aging

National Instituteon Aging

National Instituteof Child Health

and HumanDevelopment

National Instituteof Child Health

and HumanDevelopment

National Institute onDeafness and Other

CommunicationDisorders

National Institute onDeafness and Other

CommunicationDisorders

National EyeInstitute

National EyeInstitute

National HumanGenome Research

Institute

National HumanGenome Research

Institute

National Heart,Lung, and Blood

Institute

National Heart,Lung, and Blood

Institute

National Instituteof Mental Health

National Instituteof Mental Health

National Instituteof NeurologicalDisorders and

Stroke

National Instituteof NeurologicalDisorders and

Stroke

National Instituteof General

Medical Sciences

National Instituteof General

Medical Sciences

National Instituteof Nursing Research

National Instituteof Nursing Research

National Libraryof Medicine

National Libraryof Medicine

Center for InformationTechnology

Center for InformationTechnology

Center for Scientific Review

Center for Scientific Review

National Centerfor Complementary

and AlternativeMedicine

National Centerfor Complementary

and AlternativeMedicine

National Instituteof Allergy and

Infectious Diseases

National Instituteof Allergy and

Infectious Diseases

National Centerfor ResearchResources

National Centerfor ResearchResources

Clinical CenterClinical Center

National Center on Minority Health andHealth Disparities

National Center on Minority Health andHealth Disparities

National Institute of Biomedical Imagingand Bioengineering

National Institute of Biomedical Imagingand Bioengineering

FogartyInternational

Center

FogartyInternational

Center

http://www.nibib.nih.gov

Current NIBIB Grant Current NIBIB Grant Portfolio AreasPortfolio Areas

• Biosensors• Biomaterials• Biomechanics• Biomedical Informatics• Drug & Gene Delivery Systems• Lab-on-a-Chip Devices/Microsystems • Medical Devices & Implant Science• Modeling, Simulation and Analysis • Nanotechnology• Rehabilitation Engineering• Surgical Tools & Techniques• Telehealth• Tissue Engineering

• Imaging Agents & Molecular Probes

• Image Displays• Image Guided Therapies &

Interventions • Image Perception • Image Processing• Magnetic, Biomagnetic &

Bioelectric Devices• Magnetic Resonance Imaging &

Spectroscopy• Nuclear Medicine• Optical Imaging & Spectroscopy• Ultrasound and Acoustics• X ray, Electron & Ion Beam

Interagency Modeling Interagency Modeling and Analysis Group and Analysis Group

Multiscale ModelingMulti-scale modeling deals with spanning scales from molecular to population and is expected to largely impact the understanding of biological processes and also further the predictive capability in biological, biomedical and environmental systems.

Genes Cellstructure-function

Tissue structure-function

Clinicalmedicine

Organ structure-function

ProteinsLipids

Carbohydrat

es

mRNA

…

30,000+genes

100,000+proteins

12 organsystems

1body

200+ celltypes

4 tissuetypes

Courtesy of Peter Hunter

Biological Scales

Funding OpportunitiesFunding Opportunities

Google: NIH ARRA – “From the Director”, budget

allocations NIH Challenge Grants – RC1 Initiative NIBIB Challenge Grants – institute specific topics

Sign up on listservs: Google: NIH Guide Listserv Google: NIBIB email updates

Email us: penggr@mail.nih.gov

American Recovery and American Recovery and Reinvestment Act of Reinvestment Act of

2009 (ARRA)2009 (ARRA)

BioComputationChallenge Grants Topics

Google: imag wiki (www.imagwiki.org/mediawiki)

Search: NIH

NIBIB BioComputationChallenge Grant Topics

01-EB-101 – Technologies to Enhance Patient Safety and Avoid Errors in the Clinical Setting

06-EB-109 – Model-Driven Biomedical Technology Development

06-EB-110 – Methods for Assessment of Imaging Technologies

06-EB-111 – Validation of Image Analysis Methods 06-EB-112 – Large-Scale Kinetics of Multiple

Signaling Pathways 10-EB-102 – User-Friendly Computing Infrastructures

for Biomedical Researchers and Clinicians 15-EB-101 – Towards the Virtual Patient

Funding OpportunityFunding Opportunity

12 NIH participatinginstitutes

3 years, 9 receipt dates

Foreign Institutions are Welcome to Apply!

PAR 08-023 ObjectivesPAR 08-023 Objectives To develop To develop multiscalemultiscale models that link at least two models that link at least two

biological scales of modeling and accurately predict biological scales of modeling and accurately predict biomedical and behavioral processes in health and disease biomedical and behavioral processes in health and disease statesstates

To develop To develop predictivepredictive, multiscale models that link to , multiscale models that link to higher higher levels of the physiomelevels of the physiome. Models must link to at least one . Models must link to at least one scale beyond molecular interactions at the cellular level scale beyond molecular interactions at the cellular level (e.g. to cell-cell, cell-environment interactions, as listed (e.g. to cell-cell, cell-environment interactions, as listed above)above)

To develop predictive, multiscale models that are To develop predictive, multiscale models that are physiologically mechanisticphysiologically mechanistic and have translational and have translational potential or clinical applicabilitypotential or clinical applicability

To bring together modeling and biomedical expertise to To bring together modeling and biomedical expertise to collaboratecollaborate on building multiscale model(s) on building multiscale model(s)

To To validatevalidate and test models with standard datasets and test models with standard datasets To develop models that can be To develop models that can be explicitly sharedexplicitly shared with other with other

modelers modelers

Interagency Modeling and Interagency Modeling and Analysis Group (IMAG)Analysis Group (IMAG)WikiWiki

http://www.imagwiki.org/mediawikihttp://www.imagwiki.org/mediawiki

10 working groups

InternationalNew effort

IMAG Multiscale Modeling IMAG Multiscale Modeling (MSM) Consortium Working (MSM) Consortium Working

GroupsGroups WG1 - WG1 - Filament Dynamics and SimulationFilament Dynamics and Simulation (FDS) (FDS) WG2 - WG2 - Cardiac and Skeletal Muscle PhysiologyCardiac and Skeletal Muscle Physiology WG3 - WG3 - Macro-To-Micro Scale Imaging and Transport in Macro-To-Micro Scale Imaging and Transport in

Human SystemsHuman Systems WG4 - WG4 - Cell Level ModelingCell Level Modeling WG5 - WG5 - High Performance Computing, Computational High Performance Computing, Computational

Issues and AlgorithmsIssues and Algorithms WG6 - WG6 - Tissue MechanicsTissue Mechanics WG7 - WG7 - Multiscale ImagingMultiscale Imaging WG8 – WG8 – Theoretical MethodsTheoretical Methods WG9 – WG9 – Nano-modelingNano-modeling WG10 – WG10 – Model SharingModel Sharing