Full name: Naoki Hiki

Office address: Gastroenterological Center

Department of Gastroenterological Surgery

Department of Director, Gastric Surgery

Department of Director, Clinical Nuturition

Cancer Institute Hospital

3-8-31 Ariake, Koto-ku, TOKYO 135-8550, Japan

TEL: ++81-3-3520-0111 (Int. 7037), FAX: ++81-3-3570-0343

Mail: naoki.hiki@jfcr.or.jp

Academic degree’s M.D., Ph.D.

Present Position: Department Director

Thesis: Title: Endotoxin binding and elimination by monocytes

Year：1999

University: The University of Tokyo

Professional specialties:

1) Gastrointestinal Surgery

2) Laparoscopic Surgery (Laparoscopic gastric Surgery)

3) Clinical Nutrition

Research fields:

Sepsis, Endotoxin and Surgical response

Minimal invasive surgery

Laparoscopic gastric cancer surgery

Clinical Nutrition

Endoscopy and endoscopic treatment

Editorial Boards:

Gastric Cancer

Langenbech`s Archives of Surgery

British Journal of Surgery

Etc.

December 4, 2016 Naoki Hiki M.D., Ph.D.,

ＣＵＲＲＩＣＬＵＭ ＶＩＴＡＥ

Ⅰ. Personal Data

Name: Naoki HIKI

Sex: Male

Birth Date: December 15, 1962

Birth Place: Fukuoka, JAPAN

Citizenship: JAPAN

Marital Status: Married, 1990; Two children

Present Address: 4-15-16-B206 Takanawa Minatoku, Tokyo, JAPAN 108-0074

Ⅱ. All Academic Degrees Obtained

1990,May Medical Docter, Kitasato University, School of Medicine

Kanagawa, JAPAN

1998, April Ph.D. , The University of Tokyo, Tokyo, JAPAN

Ⅲ. All Stages of the University Education

1984, Apr. - 1990, Mar. M.D., cum laude, Kitasato University

School of Medicine, Kanagawa, JAPAN

1995, Apr.- Present The University of Tokyo, Postgraduate School

Ⅳ.Professional Training and Employment:

1990, April Passed the Examination of National Board

1990, Jun -1991, Jun. Medical Stuff in General Surgery, University of Tokyo

1991, Jul -1991, Dec. Medical Stuff in Trauma and Critical, Care Center,

Teikyo University, Tokyo

1992, Jan -1992, Jun Medical Stuff in Anesthesiology, University of Tokyo

1992, Jul.-1993, Jan. Research Fellowship in General Surgery,

University of Ulm, Ulm, Germany

1993, Feb.-1993, Mar. Medical Stuff in General Sugery, University of Tokyo

1993, Mar-1995 March Medical Stuff in General Surgery,

Ohme-City Hospital, Tokyo

1995, April-1998 April The University of Tokyo, Postgraduate School

1995,Oct-1997, Oct. Research Fellowship in General Surgery, University of

Ulm, Ulm, Germany

1998 April-2005 March Assistant Professor in Department of Gastrointestinal Surgery

The University of Tokyo

2005 April-Present Department of Gastroenterological Surgery Divsion Director, Gastric Surgery

Department of Director, Clinical Nuturition

Cancer Institute Hospital, Tokyo

2014 April-Present Visiting Professor

Department of Surgery, Institute of Gastroenterology

Tokyo Womens Medical University

Ⅴ. Study and Research in Germany

(1) 1992, Jul. - 1993, Jan, (2) 1995, Oct – 1997,Nov

University of Ulm, Department of Surgery

Research fellowship

Financed by German Research Association

Hans G. Beger, M.D., FACS, Professor of Surgery

University of Ulm, Steinhoevelstrasse 9,

89075 Ulm, Germany

I affirm that the above statement is true and correct in every respect.

Tokyo, 16 January, 2020

Publications in English

1 Hiki, N., Berger, D., Buttenschoen, K. 1, Endotoxemia and specific antibody behavior against

different endotoxins following multiple injuries. 1995, J Trauma 38: 794-801,

2 Buttenschoen, K., Berger, D., Hiki, N. Plasma concentrations of endotoxin and antiendotoxin

antibodies in patients with multiple injuries: a prospective clinical study. 1996, Eur J Surg

162: 853-860,

3 Hiki, N., Mimura, Y. 1, Effect of renal denervation on phosphate excretion in endotoxemic

rats. 1997, Endocr J 44: 739-744,

4 Hiki, N., Berger, D., Prigl, C. 1, Endotoxin binding and elimination by monocytes: secretion

of soluble CD14 represents an inducible mechanism counteracting reduced expression of

membrane CD14 in patients with sepsis and in a patient with paroxysmal nocturnal

hemoglobinuria. 1998, Infect Immun 66: 1135-1141,

5 Hiki, N., Mimura, Y. 1, Atrial natriuretic peptide has no potential to protect against endotoxin-

induced acute renal failure in the absence of renal nerves. 1998, Endocr J 45: 75-81,

6 Beger, H.G., Treitschke, F., Gansauge, F., Hiki, N. Tumor of the ampulla of Vater: experience with

local or radical resection in 171 consecutively treated patients. 1999, Arch Surg 134: 526-532,

7 Hiki, N., Berger, D., Dentener, M.A. 1, Changes in endotoxin-binding proteins during major

elective surgery: important role for soluble CD14 in regulation of biological activity of systemic

endotoxin. 1999, Clin Diagn Lab Immunol 6: 844-850,

8 Hiki, N., Berger, D., Mimura, Y. 1, Release of endotoxin-binding proteins during major elective

surgery: role of soluble CD14 in phagocytic activation. 2000, World J Surg 24: 499-506,

9 Buttenschoen, K., Berger, D., Hiki, N. Endotoxin and antiendotoxin antibodies in patients with

acute pancreatitis. 2000, Eur J Surg 166: 459-466,

10 Kanauchi, H., Mimura, Y., Hiki, N. Catecholamine and cytokine response to laparoscopic

adrenalectomy in patients with pheochromocytoma. 2000, Biomed Pharmacother 54 Suppl 1:

191s-193s,

11 Ogawa, T., Mimura, Y., Hiki, N. Ischaemic preconditioning ameliorates functional disturbance

and impaired renal perfusion in rat ischaemia-reperfused kidneys. 2000, Clin Exp Pharmacol

Physiol 27: 997-1001,

12 Asai, K., Hiki, N., Mimura, Y. 2, Gender differences in cytokine secretion by human peripheral

blood mononuclear cells: role of estrogen in modulating LPS-induced cytokine secretion in an ex

vivo septic model. 2001, Shock 16: 340-343,

13 Hiki, N., Mimura, Y., Ogawa, T. 1, Pathophysiological relevance of the CD14 receptor in surgical

patients: biological activity of endotoxin is regulated by the CD14 receptor. 2001, J Endotoxin

Res 7: 461-466,

14 Hiki, N., Kurosaka, H., Tatsutomi, Y. 1, Case of gastric outlet stenosis with features of pyloric

stenosis diagnosed by using peppermint oil solution as a new antispasmodic. 2003, Digestive

Endoscopy 15: 224-227,

15 Hiki, N., Mimura, Y., Hatao, F. 1, Sublethal endotoxin administration evokes super-resistance to

systemic hypoxia in rats. 2003, J Trauma 54: 584-589,

16 Hiki, N., Kurosaka, H., Tatsutomi, Y. 1, Peppermint oil reduces gastric spasm during upper

endoscopy: a randomized, double-blind, double-dummy controlled trial. 2003, Gastrointest

Endosc 57: 475-482,

17 Kubota, K., Nakanishi, H., Hiki, N. Quantitative detection of micrometastases in the lymph nodes

of gastric cancer patients with real-time RT-PCR: a comparative study with

immunohistochemistry. 2003, Int J Cancer 105: 136-143,

18 Tsuji, E., Hiki, N., Nomura, S. 2, Simultaneous onset of acute inflammatory response, sepsis-like

symptoms and intestinal mucosal injury after cancer chemotherapy. 2003, Int J Cancer 107: 303-

308,

19 Kubota, K., Hiki, N., Shimizu, N. 2, Utility of [13C] urea breath test for Helicobacter pylori

detection in partial gastrectomy patients. 2003, Dig Dis Sci 48: 2135-2138,

20 Hiki, N., Takeshita, Y., Kubota. 1, A seasonal variation in the onset of postoperative adhesive

small bowel obstruction is related to changes in the climate. 2004, Dig Liver Dis 36: 125-129,

21 Hatao, F., Muroi, M., Hiki, N. Prolonged Toll-like receptor stimulation leads to down-regulation

of IRAK-4 protein. 2004, J Leukoc Biol 76: 904-908,

22 Hatao, F., Hiki, N., Mimura, Y. 2, The induction of super-resistance using synthetic

lipopolysaccharide receptor agonist rescues fatal endotoxemia in rats without excessive

immunosuppression. 2005, Shock 23: 365-370,

23 Kubota, K., Shimizu, N., Nozaki, K., Hiki, N. Efficacy of triple therapy plus cetraxate for the

Helicobacter pylori eradication in partial gastrectomy patients. 2005, Dig Dis Sci 50: 842-846,

24 Hiki, N. ,Kaminishi, M.1, Pylorus-preserving gastrectomy in gastric cancer surgery--open and

laparoscopic approaches. 2005, Langenbecks Arch Surg 390: 442-447,

25 Shimoyama, S., Imamura, K., Hiki, N. Performance of outpatient regimen of S-1 in combination

with fractional cisplatin for advanced or recurrent gastric cancers: a phase I study. 2005, Int J Clin

Oncol 10: 251-255,

26 Hiki, N., Shimizu, N., Yamaguchi, H. 1, Manipulation of the small intestine as a cause of the

increased inflammatory response after open compared with laparoscopic surgery. 2006, Br J Surg

93: 195-204,

27 Hiki, N., Shimoyama, S., Yamaguchi, H. 1, Laparoscopy-assisted pylorus-preserving gastrectomy

with quality controlled lymph node dissection in gastric cancer operation. 2006, J Am Coll Surg

203: 162-169,

28 Mizuno, S., Kato, K., Ono, Y., Hiki, N. Oral peppermint oil is a useful antispasmodic for double-

contrast barium meal examination. 2006, J Gastroenterol Hepatol 21: 1297-1301,

29 Yamamoto, N., Nakai, Y., Sasahira, N., Hiki, N. Efficacy of peppermint oil as an antispasmodic

during endoscopic retrograde cholangiopancreatography. 2006, J Gastroenterol Hepatol 21: 1394-

1398,

30 Nozaki, K., Nomura, S., Shimizu, N., Hiki, N. Helicobacter pylori-negative / API2-MALT1

translocation-negative low-grade MALT lymphoma. 2006, Gastric Cancer 9: 229-234,

31 Kubota, K., Katayama, A., Takeshita, Y., Hiki, N. Effect of imatinib mesylate in a patient with a

metastatic gastrointestinal stromal tumor with a c-kit mutation in exon 11. 2007, Dig Dis Sci 52:

1725-1729,

32 Hiki, N., Fukunaga, T., Yamaguchi, T. 1, Laparoscopic esophagogastric circular stapled

anastomosis: a modified technique to protect the esophagus. 2007, Gastric Cancer 10: 181-186,

33 Tokunaga, M., Ohyama, S., Nunobe, S., Hiki, N. Advanced gastric cancer with a duplicated

hepatic artery: preoperative diagnostic value of multidetector-row computed tomography for

surgical resection. 2007, Gastric Cancer 10: 191-195,

34 Nunobe, S., Hiki, N., Fukunaga, T. 2, Laparoscopy-assisted pylorus-preserving gastrectomy:

preservation of vagus nerve and infrapyloric blood flow induces less stasis. 2007, World J Surg

31: 2335-2340,

35 Nunobe, S., Hiki, N., Ohyama, S. 2, Survival benefits of pancreatoduodenectomy for gastric

cancer: relationship to the number of lymph node metastases. 2008, Langenbecks Arch Surg 393:

157-162,

36 Hiki, N., Yamamoto, Y., Fukunaga, T. 1, Laparoscopic and endoscopic cooperative surgery for

gastrointestinal stromal tumor dissection. 2008, Surg Endosc 22: 1729-1735,

37 Nunobe, S., Ohyama, S., Sonoo, H., Hiki, N. Benefit of mediastinal and para-aortic lymph-node

dissection for advanced gastric cancer with esophageal invasion. 2008, J Surg Oncol 97: 392-395,

38 Tokunaga, M., Ohyama, S., Hiki, N. Endoscopic evaluation of reflux esophagitis after proximal

gastrectomy: comparison between esophagogastric anastomosis and jejunal interposition. 2008,

World J Surg 32: 1473-1477,

39 Shimoyama, S., Imamura, K., Hiki, N. Nutritional comparisons between a pylorus-preserving

gastrectomy with and without suprapyloric lymph node clearance: a preliminary report. 2007,

Hepatogastroenterology 54: 2401-2405,

40 Nunobe, S., Hiki, N., Fukunaga, T. 2, Previous laparotomy is not a contraindication to

laparoscopy-assisted gastrectomy for early gastric cancer. 2008, World J Surg 32: 1466-1472,

41 Seki, M., Ninomiya, E., Takano, K., Hiki, N. Pancreatogram findings for carcinoma in situ (CIS)

of the pancreas seen on endoscopic retrograde cholangiopancreatography and postoperative

pancreatography of resected specimens: can CIS be diagnosed preoperatively? 2008,

Pancreatology 8: 142-152,

42 Tokunaga, M., Hiki, N., Fukunaga, T. 2, Quality control and educational value of laparoscopy-

assisted gastrectomy in a high-volume center. 2009, Surg Endosc 23: 289-295,

43 Seto, Y., Fukuda, T., Yamada, K., Hiki, N. Celiac lymph nodes: distant or regional for thoracic

esophageal carcinoma? 2008, Dis Esophagus 21: 704-707,

44 Tokunaga, M., Shirabe, K., Yamashita, N., Hiki, N. Bowel obstruction due to sciatic hernia. 2008,

Dig Surg 25: 185-186,

45 Tokunaga, M., Hiki, N., Fukunaga, T. 2, Does age matter in the indication for laparoscopy-

assisted gastrectomy? 2008, J Gastrointest Surg 12: 1502-1507,

46 Hiki, N., Fukunaga, T., Yamaguchi, T. 1, The benefits of standardizing the operative procedure for

the assistant in laparoscopy-assisted gastrectomy for gastric cancer. 2008, Langenbecks Arch Surg

393: 963-971,

47 Hiki, N., Fukunaga, T., Tokunaga, M. 1, An effective duodenum bulb mobilization for

extracorporeal Billroth I anastomosis of laparoscopic gastrectomy. 2009, J Gastrointest Surg 13:

230-235,

48 Hiki, N., Fukunaga, T., Yamaguchi, T. 1, Cut-and-Screw Insertion: A Method for Safe and Speedy

Secondary Trocar Insertion in Laparoscopic Surgery. 2008, Surg Technol Int 17: 121-125,

49 Fukuda, T., Seto, Y., Yamada, K., Hiki, N. Can immune-enhancing nutrients reduce postoperative

complications in patients undergoing esophageal surgery? 2008, Dis Esophagus 21: 708-711,

50 Hiki, N., Maetani, I., Suzuki, Y. 1, Reduced risk of peristomal infection of direct percutaneous

endoscopic gastrostomy in cancer patients: comparison with the pull percutaneous endoscopic

gastrostomy procedure. 2008, J Am Coll Surg 207: 737-744,

51 Tokunaga, M., Hiki, N., Ohyama, S. 2, Effects of reconstruction methods on a patient's quality of

life after a proximal gastrectomy: subjective symptoms evaluation using questionnaire survey.

2009, Langenbecks Arch Surg 394: 637-641,

52 Hiki, N., Fukunaga, T., Yamaguchi, T. 1, Increased fat content and body shape have little effect on

the accuracy of lymph node retrieval and blood loss in laparoscopic distal gastrectomy for gastric

cancer. 2009, J Gastrointest Surg 13: 626-633,

53 Nunobe, S., Ohyama, S., Miyata, S., Hiki, N. Incidence of gastric cancer in the remnant stomach

after proximal gastrectomy. 2008, Hepatogastroenterology 55: 1855-1858,

54 Tokunaga, M., Ohyama, S., Hiki, N. Therapeutic value of lymph node dissection in advanced

gastric cancer with macroscopic duodenum invasion: is the posterior pancreatic head lymph node

dissection beneficial? 2009, Ann Surg Oncol 16: 1241-1246,

55 Tokunaga, M., Hiki, N., Fukunaga, T. 2, Laparoscopy-assisted distal gastrectomy with D2 lymph

node dissection following standardization--a preliminary study. 2009, J Gastrointest Surg 13:

1058-1063,

56 Tokunaga, M., Ohyama, S., Hiki, N. Investigation of the lymphatic stream of the stomach in

gastric cancer with solitary lymph node metastasis. 2009, World J Surg 33: 1235-1239,

57 Tokunaga, M., Hiki, N., Fukunaga, T. 2, Better prognosis of T2 gastric cancer with preoperative

diagnosis of early gastric cancer. 2009, Ann Surg Oncol 16: 1514-1519,

58 Tokunaga, M., Hiki, N., Fukunaga, T. 2, Effect of individual fat areas on early surgical outcomes

after open gastrectomy for gastric cancer. 2009, Br J Surg 96: 496-500,

59 Saiura, A., Yamamoto, J., Kokudo, N., Hiki, N. Intrahepatic cholangiocarcinoma: analysis of 44

consecutive resected cases including 5 cases with repeat resections. 2009, Am J Surg,;

60 Yoshikawa, K., Hiki, N., Fukunaga, T. 2, Increased risk of lymph node metastasis in mucosal

gastric cancer with extra indication for endoscopic mucosal resection. 2009, J Am Coll Surg,

1045-1050,

61 M. Tokunaga, N. Hiki, T. Fukunaga, H. Kuroyanagi, A. Miki, T. Akiyoshi, and T. Yamaguchi.

Laparoscopic surgery for synchronous gastric and colorectal cancer: a preliminary experience.

Langenbecks Arch.Surg. 395 (3):207-210, 2010.

62 Ohyama, S., Tokunaga, M., Hiki, N. A clinicopathological study of gastric stump carcinoma

following proximal gastrectomy. 2009, Gastric Cancer 12: 88-94,

63 Fukunaga, T., Hiki, N., Tokunaga, M. 2, Left-sided approach for suprapancreatic lymph node

dissection in laparoscopy-assisted distal gastrectomy without duodenal transection. 2009, Gastric

Cancer 12: 106-112,

64 Akiyoshi, T., Kuroyanagi, H., Oya, M., Hiki, N. Laparoscopic rectal resection for primary rectal

cancer combined with open upper major abdominal surgery: initial experience. 2009,

Hepatogastroenterology 56: 571-574,

67 M. Tokunaga, N. Hiki, T. Fukunaga. 2, Better 5-year survival rate following curative gastrectomy

in overweight patients. 2009, Ann.Surg.Oncol 16 (12):3245-3251,

65 Hiki, N., Sano, T., Fukunaga, T. 1, Survival benefit of pylorus-preserving gastrectomy in early

gastric cancer. 2009, J Am Coll Surg 209 (3); 297-301,

68 N. Hiki, T. Fukunaga, M. Tokunaga. 1, An effective duodenum bulb mobilization for

extracorporeal Billroth I anastomosis of laparoscopic gastrectomy. 2009, J.Gastrointest.Surg 13

(2):230-235,

69 N. Hiki, T. Fukunaga, T. Yamaguchi, T. 1, Increased fat content and body shape have little effect

on the accuracy of lymph node retrieval and blood loss in laparoscopic distal gastrectomy for

gastric cancer. 2009, J.Gastrointest.Surg 13 (4):626-633,

70 M. Tokunaga, S. Ohyama, N. Hiki, T. Investigation of the lymphatic stream of the stomach in

gastric cancer with solitary lymph node metastasis. 2009, World J.Surg 33 (6):1235-1239,

71 M. Tokunaga, N. Hiki, T. Fukunaga. 2, Laparoscopy-assisted distal gastrectomy with D2 lymph

node dissection following standardization--a preliminary study. 2009, J.Gastrointest.Surg 13

(6):1058-1063,

72 M. Tokunaga, N. Hiki, T. Fukunaga. 2, Quality control and educational value of laparoscopy-

assisted gastrectomy in a high-volume center. 2009, Surg.Endosc 23 (2):289-295,

73 M. Tokunaga, N. Hiki, T. Fukunaga. 2, Better prognosis of T2 gastric cancer with preoperative

diagnosis of early gastric cancer. 2009, Ann.Surg.Oncol 16 (6):1514-1519,

74 M. Tokunaga, S. Ohyama, N. Hiki. Therapeutic value of lymph node dissection in advanced

gastric cancer with macroscopic duodenum invasion: is the posterior pancreatic head lymph node

dissection beneficial? 2009, Ann.Surg.Oncol 16 (5):1241-1246,

75 M. Tokunaga, S. Ohyama, K. Kuraoka, N. Hiki. Twenty-two metachronous multiple signet-ring

cell carcinomas treated with repeated gastrectomies and repeated endoscopic mucosal resections:

report of a case. 2009, Surg.Today 39 (5):430-433,

76 M. Tokunaga, N. Hiki, T. Fukunaga, T. 2, Effect of individual fat areas on early surgical

outcomes after open gastrectomy for gastric cancer. 2009, Br.J.Surg. 96 (5):496-500,

77 D. Ichikawa, N. Hiki, T. Fukunaga. 2, Usefulness of standardization in spreading of laparoscopy-

assisted distal gastrectomy. 2010, Hepatogastroenterology 57 (101):975-979,

78 H. Katai, M. Sasako, H. Fukuda, N. Hiki. Safety and feasibility of laparoscopy-assisted distal

gastrectomy with suprapancreatic nodal dissection for clinical stage I gastric cancer: a

multicenter phase II trial (JCOG 0703). 2010, Gastric.Cancer 13 (4):238-244,

79 M. Tokunaga, S. Ohyama, N. Hiki. Can superextended lymph node dissection be justified for

gastric cancer with pathologically positive para-aortic lymph nodes? 2010, Ann.Surg.Oncol 17

(8):2031-2036,

80 M. Tokunaga, N. Hiki, T. Fukunaga. 2, Laparoscopy-assisted gastrectomy for patients with earlier

upper abdominal open surgery. 2010, Surg.Laparosc.Endosc.Percutan.Tech 20 (1):16-19,

81 M. Tokunaga, N. Hiki, T. Fukunaga. 2, Laparoscopic surgery for synchronous gastric and

colorectal cancer: a preliminary experience. 2010, Langenbecks Arch.Surg 395 (3):207-210,

82 Y. Yamamoto, J. Fujisaki, T. Hirasawa, N. Hik. Therapeutic outcomes of endoscopic submucosal

dissection of undifferentiated-type intramucosal gastric cancer without ulceration and

preoperatively diagnosed as 20 millimetres or less in diameter. 2010, Dig.Endosc 22 (2):112-118,

83 H. S. Ahn, J. H. Yook, C. H. Park, Y. K. Park, W. Yu, M. S. Lee, H. Sang-Uk, K. W. Ryu, T. S.

Sohn, H. H. Kim, S. H. Choi, S. H. Noh, N. Hiki, T. Sano, and H. K. Yang. General perioperative

management of gastric cancer patients at high-volume centers. Gastric.Cancer 14 (2):178-182,

2011.

84 N. Hiki, M. Kaminishi, T. Hasunuma, M. Nakamura, S. Nomura, N. Yahagi, H. Tajiri, and H.

Suzuki. A phase I study evaluating tolerability, pharmacokinetics, and preliminary efficacy of L-

menthol in upper gastrointestinal endoscopy. Clin.Pharmacol.Ther. 90 (2):221-228, 2011.

85 N. Hiki, M. Kaminishi, K. Yasuda, N. Uedo, H. Honjo, N. Matsuhashi, T. Hiratsuka, C. Sekine,

S. Nomura, N. Yahagi, H. Tajiri, and H. Suzuki. Antiperistaltic effect and safety of L-menthol

sprayed on the gastric mucosa for upper GI endoscopy: a phase III, multicenter, randomized,

double-blind, placebo-controlled study. Gastrointest.Endosc. 73 (5):932-941, 2011.

86 N. Hiki, M. Kaminishi, S. Tanabe, J. Fujisaki, J. Yoshino, M. Iguchi, H. Kobayashi, K. Ashida, T.

Kawabe, T. Kawano, S. Nomura, N. Yahagi, H. Tajiri, and H. Suzuki. An open-label, single-arm

study assessing the efficacy and safety of L: -menthol sprayed onto the gastric mucosa during

upper gastrointestinal endoscopy. J.Gastroenterol. 46 (7):873-882, 2011.

87 X. Jiang, N. Hiki, S. Nunobe, T. Fukunaga, K. Kumagai, K. Nohara, H. Katayama, S. Ohyama, T.

Sano, and T. Yamaguchi. Long-term outcome and survival with laparoscopy-assisted pylorus-

preserving gastrectomy for early gastric cancer. Surg.Endosc. 25 (4):1182-1186, 2011.

88 X. Jiang, N. Hiki, S. Nunobe, T. Fukunaga, K. Kumagai, K. Nohara, T. Sano, and T. Yamaguchi.

Postoperative outcomes and complications after laparoscopy-assisted pylorus-preserving

gastrectomy for early gastric cancer. Ann.Surg. 253 (5):928-933, 2011.

89 X. Jiang, N. Hiki, H. Yoshiba, S. Nunobe, K. Kumagai, T. Sano, and T. Yamaguchi. Laparoscopy-

assisted gastrectomy in patients with previous endoscopic resection for early gastric cancer.

Br.J.Surg. 98 (3):385-390, 2011.

90 X. Jiang, N. Hiki, S. Nunobe, K. Nohara, K. Kumagai, T. Sano, and T. Yamaguchi. Laparoscopy-

assisted subtotal gastrectomy with very small remnant stomach: a novel surgical procedure for

selected early gastric cancer in the upper stomach. Gastric.Cancer 14 (2):194-199, 2011.

91 K. Kubota, Y. Tatsutomi, M. Kitajima, K. Mafune, K. Ohta, M. Yoshida, T. Suwa, J. Kuroda, N.

Hiki, Y. Seto, and M. Kaminishi. Physiological evaluation of residual stomach motility after local

resection in conscious dogs. Surg.Today 41 (5):680-687, 2011.

92 K. Kumagai, N. Hiki, S. Nunobe, X. Jiang, T. Kubota, S. Aikou, R. Watanabe, S. Tanimura, T.

Sano, Y. Kitagawa, and T. Yamaguchi. Different features of complications with Billroth-I and

Roux-en-Y reconstruction after laparoscopy-assisted distal gastrectomy. J.Gastrointest.Surg. 15

(12):2145-2152, 2011.

93 S. Mine and N. Hiki. [Nutritional management for esophageal cancer]. Nihon Rinsho 69 Suppl

6:438-443, 2011.

94 S. Nunobe, N. Hiki, S. Tanimura, T. Kubota, K. Kumagai, T. Sano, and T. Yamaguchi. Three-step

esophagojejunal anastomosis with atraumatic anvil insertion technique after laparoscopic total

gastrectomy. J.Gastrointest.Surg. 15 (9):1520-1525, 2011.

95 S. Nunobe, N. Hiki, S. Ohyama, S. Aikou, T. Sano, and T. Yamaguchi. Outcome of surgical

treatment for patients with locoregional recurrence of gastric cancer. Langenbecks Arch.Surg. 396

(2):161-166, 2011.

96 A. Saiura, J. Yamamoto, N. Kokudo, R. Koga, M. Seki, N. Hiki, K. Yamada, T. Natori, and T.

Yamaguchi. Intrahepatic cholangiocarcinoma: analysis of 44 consecutive resected cases including

5 cases with repeat resections. Am.J.Surg. 201 (2):203-208, 2011.

97 M. Tokunaga, N. Hiki, T. Fukunaga, A. Miki, S. Ohyama, S. Miyata, and T. Yamaguchi. Learning

curve of laparoscopy-assisted gastrectomy using a standardized surgical technique and an

established educational system. Scand.J.Surg. 100 (2):86-91, 2011.

98 M. Tokunaga, N. Hiki, T. Fukunaga, S. Ohyama, S. Nunobe, K. Yamada, and T. Yamaguchi. Is

preservation of the celiac branch of the vagal nerve effective in preventing stasis following

pylorus-preserving gastrectomy? Hepatogastroenterology 58 (107-108):1046-1050, 2011.

99 M. Tokunaga, S. Ohyama, N. Hiki, T. Fukunaga, N. Yamamoto, and T. Yamaguchi. Incidence and

prognostic value of lymph node metastasis on c-Kit-positive gastrointestinal stromal tumors of

the stomach. Hepatogastroenterology 58 (109):1224-1228, 2011.

100 Y. Akashi, N. Hiki, S. Nunobe, X. Jiang, and T. Yamaguchi. Safe management of anastomotic

leakage after gastric cancer surgery with enteral nutrition via a nasointestinal tube. Langenbecks

Arch.Surg. 397 (5):737-744, 2012.

101 N. Hiki, M. Kaminishi, K. Yasuda, N. Uedo, M. Kobari, T. Sakai, T. Hiratsuka, K. Ohno, H.

Honjo, S. Nomura, N. Yahagi, H. Tajiri, and H. Suzuki. Multicenter phase II randomized study

evaluating dose-response of antiperistaltic effect of L-menthol sprayed onto the gastric mucosa

for upper gastrointestinal endoscopy. Dig.Endosc. 24 (2):79-86, 2012.

102 X. Jiang, N. Hiki, S. Nunobe, K. Kumagai, K. Nohara, T. Sano, and T. Yamaguchi. Postoperative

pancreatic fistula and the risk factors of laparoscopy-assisted distal gastrectomy for early gastric

cancer. Ann.Surg.Oncol. 19 (1):115-121, 2012.

103 T. Kubota, S. Ohyama, N. Hiki, S. Nunobe, N. Yamamoto, and T. Yamaguchi. Endocrine

carcinoma of the stomach: clinicopathological analysis of 27 surgically treated cases in a single

institute. Gastric.Cancer, 2012.

104 S. Mine, K. Yamada, H. Grabsch, T. Sano, A. Ishiyama, T. Hirasawa, N. Yamamoto, N. Hiki, and

T. Yamaguchi. The prognostic significance of tumor laterality in patients with esophageal

squamous cell carcinoma. J.Surg.Oncol. 105 (1):66-70, 2012.

105 Y. Akashi, N. Hiki, S. Nunobe, X. Jiang, and T. Yamaguchi. Safe management of anastomotic

leakage after gastric cancer surgery with enteral nutrition via a nasointestinal tube. Langenbecks

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106 S. Nunobe, N. Hiki, T. Gotoda, T. Murao, K. Haruma, H. Matsumoto, T. Hirai, S. Tanimura, T.

Sano, and T. Yamaguchi. Successful application of laparoscopic and endoscopic cooperative

surgery (LECS) for a lateral-spreading mucosal gastric cancer. Gastric.Cancer 15 (3):338-342,

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107 T. Yoshikawa, N. Hiki, M. Taguri, T. Sano, S. Nunobe, H. Taniguchi, R. Fukushima, H. Cho, S.

Morita, and A. Tsuburaya. A Phase III Trial to Evaluate the Effect of Perioperative Nutrition

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108 H. Lee, N. Shiraishi, H. Kim, N. Hiki, I. Uyama, Sh Choi, H. Yang, and S. Kitano. Standard of

practice on laparoscopic gastric cancer surgery in Korea and Japan: Experts' survey. Asian

J.Endosc.Surg. 5 (1):5-11, 2012.

109 X. Jiang, N. Hiki, S. Nunobe, K. Kumagai, T. Kubota, S. Aikou, T. Sano, and T. Yamaguchi.

Prognostic importance of the inflammation-based Glasgow prognostic score in patients with

gastric cancer. Br.J.Cancer 107 (2):275-279, 2012.

110 N. Takemura, A. Saiura, R. Koga, J. Arita, R. Yoshioka, Y. Ono, N. Hiki, T. Sano, J.

Yamamoto, N. Kokudo, and T. Yamaguchi. Long-term outcomes after surgical resection for

gastric cancer liver metastasis: an analysis of 64 macroscopically complete resections.

Langenbecks Arch.Surg. 397 (6):951-957, 2012.

111 T. Yoshikawa, N. Hiki, M. Taguri, T. Sano, S. Nunobe, H. Taniguchi, R. Fukushima, H. Cho,

S. Morita, and A. Tsuburaya. A Phase III trial to evaluate the effect of perioperative nutrition

enriched with eicosapentaenoic acid on body weight loss after total gastrectomy for T2-T4a

gastric cancer. Jpn.J.Clin.Oncol. 42 (5):459-462, 2012.

112 H. J. Lee, N. Shiraishi, H. H. Kim, N. Hiki, I. Uyama, S. H. Choi, H. K. Yang, and S. Kitano.

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survey. Asian J.Endosc.Surg. 5 (1):5-11, 2012.

113 T. Kubota, N. Hiki, S. Nunobe, K. Kumagai, S. Aikou, R. Watanabe, T. Sano, and T.

Yamaguchi. Significance of the inflammation-based Glasgow prognostic score for short- and

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114 S. Nunobe, N. Hiki, S. Tanimura, K. Nohara, T. Sano, and T. Yamaguchi. The clinical safety

of performing laparoscopic gastrectomy for gastric cancer by trainees after sufficient

experience in assisting. World J.Surg. 37 (2):424-429, 2013.

115 S. Mine, T. Sano, N. Hiki, K. Yamada, S. Nunobe, and T. Yamaguchi. Lymphadenectomy

around the left renal vein in Siewert type II adenocarcinoma of the oesophagogastric

junction. Br.J.Surg. 100 (2):261-266, 2013.

116 M. Tokunaga, T. Sano, S. Ohyama, N. Hiki, T. Fukunaga, K. Yamada, and T. Yamaguchi.

Clinicopathological characteristics and survival difference between gastric stump carcinoma

and primary upper third gastric cancer. J.Gastrointest.Surg. 17 (2):313-318, 2013.

117 N. Hiki, S. Nunobe, T. Kubota, and X. Jiang. Function-preserving gastrectomy for early

gastric cancer. Ann.Surg.Oncol. 20 (8):2683-2692, 2013.

118 T. Fukunaga, N. Hiki, T. Kubota, S. Nunobe, M. Tokunaga, K. Nohara, T. Sano, and T.

Yamaguchi. Oncologic outcomes of laparoscopy-assisted distal gastrectomy for gastric

cancer. Ann.Surg.Oncol. 20 (8):2676-2682, 2013.

119 S. Mine, T. Sano, N. Hiki, K. Yamada, T. Kosuga, S. Nunobe, and T. Yamaguchi. Proximal

margin length with transhiatal gastrectomy for Siewert type II and III adenocarcinomas of the

oesophagogastric junction. Br.J.Surg. 100 (8):1050-1054, 2013.

120 M. Fujishiro, M. Kaminishi, N. Hiki, I. Oda, J. Fujisaki, N. Uedo, M. Kaise, S. Tanabe, M.

Iguchi, N. Matsuhashi, S. Nomura, H. Tajiri, N. Yahagi, and H. Suzuki. Efficacy of spraying l-

menthol solution during endoscopic treatment of early gastric cancer: a phase III,

multicenter, randomized, double-blind, placebo-controlled study. J.Gastroenterol. 49 (3):446-

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121 N. Hiki. Present features and future vision of laparoscopy-assisted total gastrectomy (LATG).

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122 K. Kumagai, N. Hiki, S. Nunobe, X. Jiang, T. Kubota, S. Aikou, S. Tanimura, T. Sano, and T.

Yamaguchi. Potentially fatal complications for elderly patients after laparoscopy-assisted

distal gastrectomy. Gastric.Cancer 17 (3):548-555, 2014.

123 T. Kubota, N. Hiki, T. Sano, S. Nomura, S. Nunobe, K. Kumagai, S. Aikou, R. Watanabe, T.

Kosuga, and T. Yamaguchi. Prognostic significance of complications after curative surgery

for gastric cancer. Ann.Surg.Oncol. 21 (3):891-898, 2014.

124 K. Kumagai, N. Hiki, S. Nunobe, S. Sekikawa, T. Chiba, T. Kiyokawa, X. Jiang, S. Tanimura,

T. Sano, and T. Yamaguchi. Totally laparoscopic pylorus-preserving gastrectomy for early

gastric cancer in the middle stomach: technical report and surgical outcomes. Gastric.Cancer

18 (1):183-187, 2015.

125 S. Mine, T. Sano, N. Hiki, K. Yamada, T. Kosuga, S. Nunobe, H. Shigaki, and T. Yamaguchi.

Thoracic lymph node involvement in adenocarcinoma of the esophagogastric junction and

lower esophageal squamous cell carcinoma relative to the location of the proximal end of the

tumor. Ann.Surg.Oncol. 21 (5):1596-1601, 2014.

126 T. Kosuga, N. Hiki, S. Nunobe, H. Noma, M. Honda, S. Tanimura, T. Sano, and T.

Yamaguchi. Feasibility and nutritional impact of laparoscopy-assisted subtotal gastrectomy

for early gastric cancer in the upper stomach. Ann.Surg.Oncol. 21 (6):2028-2035, 2014.

127 M. Honda, N. Hiki, S. Nunobe, M. Ohashi, T. Kiyokawa, T. Sano, and T. Yamaguchi. Long-

term and surgical outcomes of laparoscopic surgery for gastric gastrointestinal stromal

tumors. Surg.Endosc. 28 (8):2317-2322, 2014

128 T. Irino, N. Hiki, S. Nunobe, M. Ohashi, S. Tanimura, T. Sano, and T. Yamaguchi. Subtotal

gastrectomy with limited lymph node dissection is a feasible treatment option for patients

with early gastric stump cancer. J.Gastrointest.Surg. 18 (8):1429-1433, 2014.

129 M. Honda, T. Wakita, Y. Onishi, S. Nunobe, N. Hiki, A. Miura, T. Nishigori, H. Kusanagi, T.

Yamamoto, K. Kobayashi, A. Boddy, and S. Fukuhara. Development and validation of a

symptom scale to evaluate postoperative patients with esophagogastric cancer.

J.Am.Coll.Surg. 219 (5):895-903, 2014.

130 N. Hiki, S. Nunobe, T. Matsuda, T. Hirasawa, Y. Yamamoto, and T. Yamaguchi.

Laparoscopic endoscopic cooperative surgery. Dig.Endosc. 27 (2):197-204, 2015.

131 T. Yoshikawa, H. Takeuchi, S. Hasegawa, I. Nozaki, K. Kishi, S. Ito, M. Ohi, S. Mine, J. Hara,

T. Matsuda, N. Hiki, and Y. Kurokawa. Theoretical therapeutic impact of lymph node

dissection on adenocarcinoma and squamous cell carcinoma of the esophagogastric

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132 T. Irino, S. Nunobe, N. Hiki, Y. Yamamoto, T. Hirasawa, M. Ohashi, J. Fujisaki, T. Sano, and

T. Yamaguchi. Laparoscopic-endoscopic cooperative surgery for duodenal tumors: a unique

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133 Y. Kurokawa, N. Hiki, T. Yoshikawa, K. Kishi, Y. Ito, M. Ohi, N. Wada, S. Takiguchi, S. Mine,

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134 T. Namikawa, N. Hiki, S. Kinami, H. Okabe, T. Urushihara, H. Kawahira, N. Fukushima, Y.

Kodera, T. Yumiba, A. Oshio, and K. Nakada. Factors that minimize postgastrectomy

symptoms following pylorus-preserving gastrectomy: assessment using a newly developed

scale (PGSAS-45). Gastric.Cancer 18 (2):397-406, 2015.

135 T. Yoshikawa, H. Takeuchi, S. Hasegawa, I. Nozaki, K. Kishi, S. Ito, M. Ohi, S. Mine, J.

Hara, T. Matsuda, N. Hiki, and Y. Kurokawa. Theoretical therapeutic impact of lymph node

dissection on adenocarcinoma and squamous cell carcinoma of the esophagogastric

junction. Gastric.Cancer 19 (1):143-149, 2016.

136 T. Irino, S. Nunobe, N. Hiki, Y. Yamamoto, T. Hirasawa, M. Ohashi, J. Fujisaki, T. Sano, and

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137 Y. Kurokawa, N. Hiki, T. Yoshikawa, K. Kishi, Y. Ito, M. Ohi, N. Wada, S. Takiguchi, S. Mine,

S. Hasegawa, T. Matsuda, and H. Takeuchi. Mediastinal lymph node metastasis and

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138 H. Kawahira, Y. Kodera, N. Hiki, M. Takahashi, S. Itoh, N. Mitsumori, Y. Kawashima, T.

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139 T. Kosuga, N. Hiki, S. Nunobe, M. Ohashi, T. Kubota, S. Kamiya, T. Sano, and T.

Yamaguchi. Does the Single-Stapling Technique for Circular-Stapled Esophagojejunostomy

Reduce Anastomotic Complications After Laparoscopic Total Gastrectomy? Ann.Surg.Oncol.

22 (11):3606-3612, 2015.

140 Y. Takatsu, N. Hiki, S. Nunobe, M. Ohashi, M. Honda, T. Yamaguchi, T. Nakajima, and T.

Sano. Clinicopathological features of gastric cancer in young patients. Gastric.Cancer, 2015.

141 T. Kiyokawa, N. Hiki, S. Nunobe, M. Honda, M. Ohashi, T. Sano, and T. Yamaguchi.

Feasibility of Gastrectomy with Standard Lymphadenectomy for Patients Over 85 Years Old

with Gastric Cancer. Ann.Surg.Oncol. 22 (12):3962-3969, 2015.

142 T. Irino, N. Hiki, M. Ohashi, S. Nunobe, T. Sano, and T. Yamaguchi. The Hit and Away

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143 S. Mine, Y. Kurokawa, H. Takeuchi, K. Kishi, Y. Ito, M. Ohi, T. Matsuda, T. Hamakawa, S.

Hasegawa, T. Yoshikawa, and N. Hiki. Distribution of involved abdominal lymph nodes is

correlated with the distance from the esophagogastric junction to the distal end of the tumor

in Siewert type II tumors. Eur.J.Surg.Oncol. 41 (10):1348-1353, 2015.

144 M. Honda, N. Hiki, S. Nunobe, M. Ohashi, K. Kumagai, Y. Hashimoto, S. Mine, S. Kamiya, T.

Sano, and T. Yamaguchi. Preoperative vs Postoperative Eradication of Helicobacter pylori in

150 Patients with Gastric Cancer: A Randomized Controlled Trial. J.Am.Coll.Surg. 221

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145 M. Honda, N. Hiki, S. Nunobe, M. Ohashi, S. Mine, M. Watanabe, S. Kamiya, T. Irino, T.

Sano, and T. Yamaguchi. Unplanned admission after gastrectomy as a consequence of fast-

track surgery: a comparative risk analysis. Gastric.Cancer, 2015.

146 T. Matsuda, N. Hiki, S. Nunobe, S. Aikou, T. Hirasawa, Y. Yamamoto, K. Kumagai, M.

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surgery for gastric submucosal tumors (with video). Gastrointest.Endosc., 2015.

147 T. Irino, N. Hiki, M. Ohashi, S. Nunobe, M. Tokunaga, T. Sano, and T. Yamaguchi.

Characteristics of gastric stump cancer: A single hospital retrospective analysis of 262

patients. Surgery 159 (6):1539-1547, 2016.

148 S. Nunobe, K. Kumagai, S. Ida, M. Ohashi, and N. Hiki. Minimally invasive surgery for

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149 T. Matsuda, Y. Kurokawa, T. Yoshikawa, K. Kishi, K. Misawa, M. Ohi, S. Mine, N. Hiki, and

H. Takeuchi. Clinicopathological Characteristics and Prognostic Factors of Patients with

Siewert Type II Esophagogastric Junction Carcinoma: A Retrospective Multicenter Study.

World J.Surg. 40 (7):1672-1679, 2016.

150 K. Kumagai, N. Hiki, S. Nunobe, T. Irino, S. Ida, M. Ohashi, T. Yamaguchi, and T. Sano.

Metastasis to the lymph nodes along the proper hepatic artery from adenocarcinoma of the

stomach. Langenbecks Arch.Surg. 401 (5):677-685, 2016.

151 M. Honda, N. Hiki, T. Kinoshita, H. Yabusaki, T. Abe, S. Nunobe, M. Terada, A. Matsuki, H.

Sunagawa, M. Aizawa, M. A. Healy, M. Iwasaki, and T. A. Furukawa. Long-term Outcomes

of Laparoscopic Versus Open Surgery for Clinical Stage I Gastric Cancer: The LOC-1 Study.

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152 Y. Inoue, A. Saiura, T. Sato, T. Ishizawa, J. Arita, Y. Takahashi, N. Hiki, T. Sano, and T.

Yamaguchi. Laparoscopic pancreatoduodenectomy combined with a novel self-assessment

system and feedback discussion: a phase 1 surgical trial following the IDEAL guidelines.

Langenbecks Arch.Surg., 2016.

153 J. Zhou, N. Hiki, S. Mine, K. Kumagai, S. Ida, X. Jiang, S. Nunobe, M. Ohashi, T. Sano, and

T. Yamaguchi. Role of Prealbumin as a Powerful and Simple Index for Predicting

Postoperative Complications After Gastric Cancer Surgery. Ann.Surg.Oncol., 2016.

154 M. Aizawa, M. Honda, N. Hiki, T. Kinoshita, H. Yabusaki, S. Nunobe, H. Shibasaki, A.

Matsuki, M. Watanabe, and T. Abe. Oncological outcomes of function-preserving

gastrectomy for early gastric cancer: a multicenter propensity score matched cohort analysis

comparing pylorus-preserving gastrectomy versus conventional distal gastrectomy.

Gastric.Cancer, 2016.

155 T. Kiyokawa, N. Hiki, S. Nunobe, M. Honda, M. Ohashi, and T. Sano. Preserving infrapyloric

vein reduces postoperative gastric stasis after laparoscopic pylorus-preserving gastrectomy.

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156