from concerns to conditions 013 print_edition- jom and jaruwan
TRANSCRIPT
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From Concern to ConditionA research-based approach to
Medical Diagnosis
Jaruwan Kittisopit,M.D. Developmental and Behavioural Pediatrician
Jom Choomchauy, M.D.Child and Adolescent Psychiatrist
20 September 2013, Bangkok
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Disclosure
The speakers have no financial relationships with or commercial interests in any products discussed in this presentation.
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Presentation Objective
• Introduction to research-based approach to medical diagnosis in the field of neurodevelopmental and neuropsychiatry.
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Concerns?
Delays, Deviation, Advance, Regression, Disequilibrium :
• Developmental milestones : GM,FM,LA,VR,SO,ADL
• Behaviors• Mental & Emotional state• Learning & Academic achievements• Family issues
Combinations!
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Significant Concerns?
Consideration Norm : Age
Ethnicity Individual profile / baseline of
development/temperament Cultural variations Onset, Severity, Duration, Progression ? Functional impairment? Different settings ? Red Flags : Early signs
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Significant Concerns?
Functional Impairment:Symptoms & Signs cause clinically significant impairment, negatively impact, interfere with or reducesocial, academic, occupational or other important areas of current functioning.
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Medical Approach • History taking• Physical examination• Developmental & Mental status examination• Further Investigations:
LaboratoriesFormal Assessments
Signs & Symptoms(S/S) Work up Dx PlanRx
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Pediatric Approach
• A child as a whole person : p/db/m
• A child as a part of Family system
• Source of information: primary & secondary
clientcaregivers3rd party: school,
agency, community
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Research & Clinical ApplicationEvidence-based practice
Study designs?
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Research & Clinical ApplicationEvidence-based practice
Classification of Research /studyRetrospective , Cross-sectional, Prospective studyExploratory, Descriptive study , Analytical studyObservational , Interventive study
Case report, Case series, Case-controlRCT : randomized, double blind,(cross over), trial
Clinical trialsEpidemiologic studyGenetic studyPsychometric validity study
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Concern Condition ??
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Conditions?• Neurodevelopmental conditions• Neuropsychiatric conditions• Brain Functions : Complex capacity , Overlapping• Neuro—Neurons—Neurotransmitters—Connectome—
Genome• Genotype & Phenotype• 1 phenotype…many genes • 1 gene many phenotypes• Developmental/Behavioral/Mental/Learning• Norm/variation/deviations/CONDITIONS• Multifactor : Nature & Nurture• SYNDROME • SPECTRUM
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BIO-PSYCHOSOCIAL Model
• Biology : Brain function, Genetic, Temperament, Brain trauma, Toxin, Infection, Nutrition etc.
• Psychosocial: Parenting, Experience, Character & Personality, School, Peers, Community, Culture etc.
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Bio-Psychosocial Interaction
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Case Vignette:NC A 13 years old South American girl with history of depressed mood for 2 months
Symptoms• Depressed mood, lonely• Negative thoughts
about herself• Difficulty concentrating• Lethargy, Loss of Energy• Guilty feeling• Irritability and agitation
Symptoms• Sense of Inferiority• Suicidal ideation• Emotionally sensitive• Social anxiety• Paranoid ideation• Auditory hallucination
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Clinical Approach
• Clinical Evaluation and Psychological tests• Diagnosis: Major Depressive Disorder, Severe with
Psychotic Features• Plan– Ongoing monitoring and Follow up sessions- Medication- Psychotherapy- Music Therapy- Family Intervention- School Consultation and Clinical Liaison
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depressed moodloss of happiness (joy)
loss of interest/pleasureloss of energy/enthusiasm
decreased alertnessdecreased self-confidence
reduced positive affect
++
++ +
DAdysfunction
NE
dysfunction
normalmood
depressed moodguilt/disgust fear/anxiety
hostilityirritabilityloneliness
increased negative affect
-- - -
-
NEdy
sfunc
tion
5HT
dysfunction
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Match Each DSM IV Diagnostic Symptom for a Major DepressiveEpisode to Hypothetically Malfunctioning Brain Circuits
S
NA
PFC
BF
AH
Hy
T
NT
SC
C
psychomotor fatigue (physical)
pleasureinterestsfatigue/energyconcentration
interest/pleasure
psychomotorfatigue (mental)
guiltsuicidalityworthlessness
mood
guiltsuicidalityworthlessnessmood
sleepappetite
fatigue (physical)
psychomotor
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Categorical & Dimensional Model
• Categorical model: Symptoms Categories, DSM IV
• Dimensional model: Functioning level, Severity, Continuum
• DSM-5— Incorporate Dimensional Model and Categorical model!
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Case Vignette : JK
• JK: 5-year Thai boy, 1st language is Thai, English is 2ndlanguage for 3 years since entered an International school :
• School concerned of his aloofness, preferred to talk and play with particular peers and toys and often had conflicts.
• Sometimes he appeared to show no sympathy to peers looking on when peers cried after their fights. He rarely spoke in English but appeared to understand however would often ask the same questions again and again to TA in Thai.
• Parents disagreed with school but were aware of his shyness especially in new situations: he is easily worried about whether he did things wrong and would often drift away during homework. He is a very talkative boy, curious and creative at home.
• He enjoys playing with other kids but has few chances to join them due to his schedule. Mostly after school he would be dropped off at his mother’s office and spend time playing with an ipad.
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Case Vignette : JK• JK: 5-year Thai boy, 1st language is Thai, English is 2ndlanguage for 3 years since entered an
International school :ESL : English as Second Language• School concerned of his aloofness, preferred to talk and play with particular peers and toys
and often had conflicts.• Sometimes he appeared to show no sympathy to peers looking on when peers cried after
their fights. He rarely spoke in English but appeared to understand however would often ask the same questions again and again to TA in Thai. Social and Communication and Play skills concerns from school
• Parents disagreed with school but were aware of his shyness especially in new situations: he is easily worried about whether he did things wrong and would often drift away during homework. He is a very talkative boy, curious and creative at home. Parents had different perspective. Slow to warm up temperament, Creative , curious, but anxious and distractible
• He enjoys playing with other kids but has few chances to join them due to his schedule. Mostly after school he would be dropped off at his mother’s office and spend time playing with an iPad. Able to socialize with same age peers in familiar situations, under-exposure to child-plays
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Case Vignette : JK 5-yr boy• ESL • Social and Communication and Play skills
concerns from school• Parents had different perspective : Slow to
warm up temperament, Creative , curious, but anxious and distractible
• Able to socialize with same age peers in familiar situations
• Under-exposure to child-plays
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What’s next?• Gather more information from different
perspectives : client, parents, school and other professionals in order to get to know a child’s profile : ability, strengths and needs , in order to provide suitable and appropriate interventions
• Evaluation :Clinical & Formal • Assessment: Diagnostic & Follow up– Developmental & Behavioral– Psychoeducational– Neurodevelopmental / Neuropsychological – Speech& Language – Physio/Occupational
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Case Vignette: JK 5-yr boy
• Clinical assessment: parent clinical interview, play-based developmental evaluation /MSE
• Diagnostic evaluation:ADI-R, ADOS,Mullen Scales, NEPSY-II (AT/EF, SP:ToM,AR)School vdo, school visitQuestionnaires: SDQ, SNAP-IV,PDDSQ
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So, Does Diagnosis Matter?Why?
• Universal Language among professionals• Practice Guidelines/Road map: for
Intervention , Counseling, Prognosis• Strengths & Needs• Future Research : etiology , specific treatment, course, prognosis
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Questions?
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Thank you