Dreaming of Tenure and IPOs while patients die: What Prevents Open Approaches to

Building Better Disease Models

THE CORRUPTION OF DENIAL

FRIEND

STRATA

TRUST HER SHE IS A DOCTOR

YET SHOULD WE?

AND I SHOULD KNOW

TRUST THE UNIVERSITIES TO HELP THE PATIENTS TO BE THE BASTIONS

OF SHARING

GARRETT FITZERALD

TRUST THE COMPANIES THE BIOTECHS THE VCs

CTCAP

AND I SHOULD KNOW

IS THERE AN ALTERNATIVE

ABCDE

“ugly duckling”

Dermoscopy

Pathology

Molecular

MD

There is no standard screening program for skin lesions; seeing an MD is self directed

Education is derived from top-down experiential knowledge

?Photos

HPI

Best accuracy of clinical diagnosis = 64% (Grin, 1990)

160k new cases/year 48k deaths in 2012 in US

Both intra- and inter- institutional data are siloed

1. activated citizens take skin pictures

2. store tons of data!

3. run algorithmic challenges in the compute space

4. give back risk-assessment & education to the citizens

virtual cycle: continuous aggregation of data enriching the model

SYNAPSE

CURATED

DATA

TOOLS/

METHODS

ANALYSES/

MODELS

RAW

DATA

BioMedicine Information Commons

Data

Generators

Data

Analysts

Experimentalists

Clinicians

Patients/

Citizens

Networked Approaches

SYNAPSE

CURATED

DATA

TOOLS/

METHODS

ANALYSES/

MODELS

RAW

DATA

BioMedical Information Commons

Data

Generators

Data

Analysts

Experimentalists

Clinicians

Patients/

Citizens

Networked Team Approaches 2

PRIVACY BARRIERS

4 REWARDS

FOR SHARING

1 USABLE

DATA

3 HOW TO

DISTRIBUTE TASKS

5 EDUCATION

BIOINFORMATICS

Sage-DREAM Breast Cancer Prognosis Challenge one month of building better disease models together

154 participants; 27 countries

334 participants; >35 countries

>500 models posted to Leaderboard

breast cancer data

Challenge Launch: July 17

Sep 26 Status

Caldos/Aparicio

IS THERE AN ALTERNATIVE

BRIDGE

IS THERE AN ALTERNATIVE

BRIDGE

PEACE

SIGN