CURRICULUM VITAE

FRANCIS XAVIER KEELEY, JR., M.D., FRCS (UROLOGY)

February 2016

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PERSONAL INFORMATION

NAME Francis Xavier Keeley, Jr.

BORN 26 May 1964, Camden, New Jersey, USA

ADDRESS 139 Westbury Road, Westbury-on-Trym, Bristol BS9 3AN

EMAIL fxkeeley@gmail.com

GMC NO. 4455460

EDUCATION St. Joseph’s Preparatory School, Philadelphia, PA

Duke University, Durham, North Carolina, B. A. (Chem) 1986

University of Aberdeen, Scotland, 1985

Washington University School of Medicine, St. Louis, M. D. 1990

QUALIFICATIONS AND ACCREDITATION

Fellow of the Edinburgh Royal College of Surgeons.

Fellowship without examination, 2001.

Fellow of the American Board of Urology (Board certified urologist), 2000;

recertification, 2008

Mediated entry onto GMC Specialist Register 1998

Endourological Society Fellowship 1998

Fellow of the Intercollegiate Board of Urology (FRCS Urology) 1997

Diplomate, National Board of Medical Examiners (U.S.) 1991

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PROFESSIONAL EMPLOYMENT

PRESENT APPOINTMENT

Consultant Urologist (1998 - )

Bristol Urological Institute, North Bristol NHS Trust

Southmead Hospital, Westbury-on-Trym, Bristol BS10 5NB

CLINICAL RESPONSIBILITIES

Apart from general urology my clinical responsibilities include the following

urological subspecialties:

• Laparoscopic urological surgery: I have a regular practice in laparoscopic

surgery for a variety of indications, including nephrectomy for benign and

malignant disease, pyeloplasty, partial nephrectomy, renal cryoablation and

adrenalectomy.

• Stone disease:

• Extracorporeal shock-wave lithotripsy: The Bristol Urological Institute

has a Storz lithotriptor for the treatment of renal and ureteral calculi, the

only fixed-site machine in the Southwest of England. The lithotriptor

provides the backbone to a comprehensive stone treatment and

prevention service.

• Joint clinic in metabolic stone disease with Dr. Helen Campbell of

nephrology.

• Percutaneous and ureteroscopic stone extraction: Bristol serves as a

referral centre for complex kidney stone disease. I carry out minimally

invasive treatment of urinary calculi in all locations using the latest

nephroscopes and ureteroscopes, both rigid and flexible, as well as the

holmium:YAG laser.

• Minimally invasive treatment of upper urinary tract transitional cell carcinoma:

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Selected patients with upper tract tumors can be treated endoscopically, thereby

preserving their kidneys. Patients are referred from across the UK to the Bristol

Urological Institute for diagnosis and treatment.

• Minimally invasive treatment of upper urinary tract obstruction: Carefully

selected patients with ureteropelvic junction (UPJ) obstruction and ureteral

strictures can be treated endoscopically. Laparoscopic pyeloplasty has emerged

as our preferred treatment option for patients with primary and secondary UPJ

obstruction. We have one of the most extensive experiences with this procedure

in the UK.

PREVIOUS APPOINTMENTS

1996-1998 Endourology Fellow, Scottish Lithotriptor Centre,

Western General Hospital, Edinburgh

1995-1996 Chief urology resident

Thomas Jefferson University Hospital, Philadelphia

1992-1995 Urology resident

Thomas Jefferson University Hospital

1990-1992 General Surgical Intern and Junior Resident

Thomas Jefferson University Hospital

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OTHER PROFESSIONAL ACTIVITIES

2011 – 2015: HONORARY SECRETARY, BRITISH ASSOCIATION OF UROLOGICAL

SURGEONS. I served as an officer and Trustee of BAUS with primary responsibility

for overseeing the Annual Scientific Meeting. I was regularly involved in issues

involving urological services and the NHS, such as commissioning of services and

training. I have taken a leadership role for the following areas: the public reporting

of individual surgeons’ outcomes; meeting with the Department of Health regarding

the setting of tariffs, especially in endourology and kidney cancer; the BAUS Section

of Endourology; liaising with NICE; and UROLINK, which supports urology in the

developing world.

2014 – PRESENT: CHAIRMAN, BAUS DATA AND AUDIT COMMITTEE. I oversee the

annual publication of surgeon’s outcomes, which now includes nephrectomy,

percutaneous nephrolithotomy, radical prostatectomy, radical cystectomy,

urethroplasty, and surgery for stress urinary incontinence.

2008 - 2011: LEAD CONSULTANT, DEPARTMENT OF UROLOGY, BRISTOL UROLOGICAL

INSTITUTE, NORTH BRISTOL NHS TRUST. I helped to facilitate a merger of the two

departments of urology in Bristol. I carried out a detailed review and redesign of

waiting list management. This process had tangible results, including a reduction in

waiting times for review cystoscopy from 6 months overdue to within the target

month; setting internal targets for urgent non-cancer cases; and instituting a safe

transfer of care policy.

Our department has a da Vinci robot, principally to do robotic radical prostatectomy

(RRP). Concerns were raised about the safe introduction of RRP by low-volume

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surgeons, so I developed guidelines for training and oversaw the safe expansion of

the technique.

2005 – 2008: COUNCIL MEMBER, BRITISH ASSOCIATION OF UROLOGICAL SURGEONS.

While serving on BAUS Council, I collaborated to publish the BAUS Guidelines for

laparoscopic training as well as for mentorship (see publications below). I have also

contributed to the development of patient information for recovery from

laparoscopic nephrectomy, in collaboration with the Royal College of Surgeons of

England and the Department of Health. I have contributed towards the BAUS

annual meeting for each of the past 14 years.

2004 - 13: BJU International (Journal). I served as a trustee and Honorary Treasurer

(2010-13) of the Executive Committee, which oversees the publication of the journal.

As Honorary Treasurer of the BJU International Company (2010-13), a charity

dedicated to promoting urological education and research, I was responsible for an

annual budget of roughly £2m and reported to the Trustees. This role involved

regular communication with the Chief Executive and Chairman. I had to educate

myself in financial matters as the Honorary Treasurer of the BJUI during challenging

times for publishers. I reported to the Trustees 4 times per year and led the

appointment of new auditors and an investment advisor.

2003 – PRESENT: NATIONAL INSTITUTE FOR CLINICAL EXCELLENCE (NICE). I have been

asked to provide expert advice on a wide range of interventional procedures. From

2008 to 2012, I served on the Interventional Procedures Advisory Committee.

2000- PRESENT: LAPAROSCOPIC TRAINING. I have participated in laparoscopic

training through BAUS-sponsored courses as well as acting as a mentor for

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consultant urologists. I have run a laparoscopy lecture course at the BAUS annual

meeting and performed live surgery in over 15 courses at national and international

meetings.

As the regional training center for urology, NBT typically attracts specialist

registrars at the end of their training. I have trained 26 specialist registrars and 11

fellows in endourology; 14 of them have been appointed as consultants with an

interest in endourology.

I have acted as a mentor for 30 consultant urologists, assisting in 67 cases at hospitals

around the UK and abroad. The mentoring process involves demonstrating

laparoscopic procedures in Bristol, then tutoring consultants as they carry out the

same procedures at their own hospital.

I have organized courses in laparoscopic renal cryoablation and acted as a preceptor

for 10 consultants.

2005- 2007: BAUS LAPAROSCOPY TRAINER. I oversaw the hands-on teaching courses

for BAUS in the UK and in Europe. Roughly 9 courses took place each year.

2005-PRESENT: FACULTY OF THE EUROPEAN SOCIETY FOR URO-TECHNOLOGY (ESUT),

an endourology subspecialty group within the European Association of Urology

which focuses on laparoscopic training.

2009-PRESENT: CLINICAL RESEARCH OFFICE OF THE ENDOUROLOGICAL SOCIETY

(CROES): Committee member for ureteroscopic procedures. I help CROES design

and run international studies and registries which have led to over 30 publications.

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2005 – 2015: JOURNAL OF ENDOUROLOGY. I was on the Editorial Board and

contributed to the Endourology Survey Section.

2010-PRESENT: JOURNAL OF ENDOUROLOGY, VIDEOUROLOGY JOURNAL. I am on the

Editorial Board.

2010-PRESENT: CANADIAN JOURNAL OF UROLOGY. I am on the Editorial Board. Since

2015, I am an Associate Editor.

2011-PRESENT: ARCHIVIO ITALIANO UROLOGIA (JOURNAL). I am on the International

Editorial Board.

2000- 2004: ETHICS COMMITTEE, SOUTHMEAD. This involved monthly meetings and

work outside the meeting, including the review of all applications from the

Department of Surgery.

2000- 2007: CLINICAL GOVERNANCE, DEPARTMENT OF UROLOGY. This commitment

involved preparing and overseeing our clinical governance sessions including

Morbidity and Mortality meetings. Within this role, I oversaw clinical audit,

reporting of adverse events, and appraisal. I have attended courses on clinical audit

and appraisal.

2000- 2011: BAUS SECTION OF ENDOUROLOGY. I served on the audit committee,

which has carried out an audit on laparoscopic nephrectomy and the equipment

available for the treatment of stones. I have developed a database for the treatment

of PUJ obstruction as well as for upper tract TCC, which are used for the prospective

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analysis of outcomes. I have overseen the development and reporting of the BAUS

national audit of laparoscopic nephrectomy (see publications below). As mentioned

above, I have overseen laparoscopic training courses for the Section.

1997- PRESENT: ENDOUROLOGICAL SOCIETY. I served on the Board of Directors (2010-

14) which oversees an annual meeting, teaching courses, and the Journal of

Endourology. I have served on the organizing committee/faculty on 15 occasions for

the World Congress of Endourology. I performed live surgery during the 2005 and

2009 meetings. I was on the organizing committee for the 2015 meeting to be held in

London.

2004- PRESENT: COCHRANE REVIEWS. Reviewer for Cochrane reviews. I have co-

authored 3 Cochrane reviews.

2000-2001: BAUS Today (Magazine). Educational Analysis Editor.

2000-2003: BJU INTERNATIONAL (Journal). I served on the Editorial Board.

2005 – 2006: EUROPEAN UROLOGY (Journal). I served on the Editorial Board.

1997- PRESENT: REVIEW OF MANUSCRIPTS for BJU International, Journal of Urology,

European Urology, Journal of Endourology, Urology, Surgical Endoscopy, British

Journal of Surgery, British Journal of Medical and Surgical Urology, Urological

Research, InnoVait, and Journal of Pediatric Urology.

1999-2001: ENDOUROLOGY FORUM. Quarterly meetings were held to discuss new

technologies and techniques, as well as to plan studies and audits.

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PUBLICATIONS

Original papers published or accepted by peer reviewed journals

1. Chancellor MB, Rivas DA, Keeley FX, Lotfi MA, Gomella LG. Similarity of the

American Urological Association Symptom Index among men with benign

prostate hyperplasia (BPH), urethral obstruction not due to BPH and detrusor

hyperreflexia without outlet obstruction. Br J Urol 74: 200-202; 1994.

2. Keeley FX, Gomella LG, Kulp-Hugues D, and Bagley DH. Laparoscopic division

of crossing vessels at the ureteropelvic junction. J Endourol 10: 163-168, 1996.

3. Keeley FX, Jr., Kulp-Hugues D, Bibbo M, McCue PA, and Bagley DH. Diagnostic

accuracy of ureteroscopic biopsy in upper tract transitional cell

carcinoma. J Urol 157: 33-37, 1997.

4. Keeley FX, Bibbo M, McCue PA, Bagley DH. The use of p53 in the diagnosis of

upper tract transitional cell carcinoma. Urology 49: 181-186, 1997.

5. Keeley FX, Bibbo M, Bagley DH. Ureteroscopic treatment and surveillance of

upper tract transitional cell carcinoma. J Urol 157: 1560-65, 1997.

6. Keeley FX Jr, Bagley DH. Adjuvant mitomycin C following endoscopic treatment

of upper tract transitional cell carcinoma. J Urol 158: 2074-7, 1997.

7. Keeley FX Jr, Tolley DA. Laparoscopic nephroureterectomy: Making

management of upper tract transitional cell carcinoma entirely minimally

invasive. Keeley FX Jr, Tolley DA. J Endourol 12: 139-141, 1998.

8. Keeley FX Jr, Tolley DA. A Review of our first 100 cases of laparoscopic

nephrectomy: defining risk factors for complications. Br J Urol 82: 615-618, 1998.

9. Keeley FX Jr, Sharma NK, Tolley DA. Hand-assisted laparoscopic

nephroureterectomy. Br J Urol Int 83: 504-505, 1999.

10. Keeley FX; Pye SD; Smith G; Tolley DA. Optimizing results of lithotripsy using

robust electromagnetic probe. J Endourol 1999;13:261-7

11. Mohan-Pillai K; Keeley FX; Moussa SA; Smith G; Tolley DA. Endourological

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management of severely encrusted ureteral stents. J Endourol 1999; 13:377-9

12. Keeley FX; Tolley DA. Retroperitoneal laparoscopy. BJU Int 1999; 84: 212-5

13. Keeley FX; Pillai M; Smith G; Chrisofos M; Tolley DA. Electrokinetic lithotripsy:

safety, efficacy and limitations of a new form of ballistic lithotripsy. BJU Int 1999;

84: 261-3

14. Keeley FX; Gialas I; Pillai M; Chrisofos M; Tolley DA. Laparoscopic

ureterolithotomy: the Edinburgh experience. BJU Int 1999; 84: 765-9

15. Keeley FX; Moussa SA; Smith G; Tolley DA. Clearance of lower-pole stones

following shock wave lithotripsy: effect of the infundibulopelvic angle. Eur Urol

1999; 36: 371-5

16. Keeley FX; Moussa SA; Miller J; Tolley DA. A prospective study of endoluminal

ultrasound versus computerized tomography angiography for detecting crossing

vessels at the ureteropelvic junction. J Urol 1999; 162: 1938-41

17. Keeley FX Jr., Tolley DA. Endoscopic management of upper tract transitional cell

carcinoma. J Neph Urol Transpl 2000; 1: 21-27.

18. Keeley FX; Tolley DA; Moussa SA. Patient selection before endopyelotomy: can

it improve the outcome? BJU Int 2000; 86: 773-6

19. Keeley FX; Tilling K; Elves A; Menezes P; Wills M; Rao N; Feneley R. Preliminary

results of a randomized controlled trial of prophylactic shock wave lithotripsy

for small asymptomatic renal calyceal stones. BJU Int 2001;87:1-8

20. Joshi HB; Stainthorpe A; Keeley FX; MacDonagh R; Timoney AG. Indwelling

ureteral stents: evaluation of quality of life to aid outcome analysis. J Endourol

2001 Mar;15(2):151-4

21. Joshi HB; Newns N; Stainthorpe A; MacDonagh RP; Keeley FX; Timoney AG.

The development and validation of a patient-information booklet on ureteric

stents. BJU Int 2001; 88: 329-34

22. Henderson A, Gujral S, Mitchelmore AE and Keeley FX, Jr. Endourological

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techniques in the management of stent complications in the renal transplant

patient. Transplantation 2002; 15: 664-6.

23. Kumar PVS, Keeley FX Jr., Timoney AG. Safe flexible ureterorenoscopy with a

dual-lumen access catheter and a safety guidewire. BJU International 2001; 88:

638.

24. Parkin J, Keeley FX Jr., Timoney AG. Laparoscopic pelvic lymphadenectomy for

locally advanced prostate cancer. BJU Int 2002; 89:14-7; discussion 17-8.

25. Parkin J, Keeley FX, Timoney AG. Flexible ureteroscopes: a user's guide. BJU Int.

2002; 90:640-3.

26. Okeke AA, Timoney AG, Keeley FX. Hand-assisted laparoscopic nephrectomy:

complications related to the hand-port site. BJU Int. 2002; 90:364-7.

27. Collins JW, Keeley FX Jr. Is there a role for prophylactic shock wave lithotripsy

for asymptomatic calyceal stones? Curr Opin Urol. 2002; 12:281-6.

28. Parkin J, Keeley FX Jr, Timoney AG. Re-auditing a regional lithotripsy service.

BJU Int. 2002; 89:653-7.

29. Parkin J, Keeley FX, Timoney AG. Analgesia for shock wave lithotripsy. J Urol.

2002; 167:1613-5.

30. Joshi HB, Okeke A, Newns N, Keeley FX Jr, Timoney AG. Characterization of

urinary symptoms in patients with ureteral stents. Urology. 2002; 59:511-6.

31. Kumar PV, Joshi HB, Timoney AG, Keeley FX Jr. Endoluminal ultrasonography

with reusable probe: preliminary results. J Endourol 2002; 16: 667-71.

32. Joshi HB, Newns N, Stainthorpe A, MacDonagh RP, Keeley FX Jr., Timoney AG.

Ureteric stent symptoms questionnaire: Development and validation of a multi-

dimensional quality of life measure. J Urol 2003; 169:160-4.

33. Joshi HB, Stainthorpe A, MacDonagh RP, Keeley FX Jr., Timoney. Indwelling

ureteral stents: Evaluation of symptoms, quality of life and utility. J Urol 2003;

169:1065-9.

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34. Parkin J, Evans S, Kumar PVS, Timoney AG, Keeley FX Jr. Endoluminal

ultrasound prior to retrograde endopyelotomy: can the results match

laparoscopic pyeloplasty? BJU Int 2003; 91: 389-91.

35. Okeke AA, Mitchelmore AE, Keeley FX, Timoney AG. A comparison of

aspiration and sclerotherapy with laparoscopic de-roofing in the management of

symptomatic simple renal cysts. BJU Int. 2003; 92:610-3.

36. Parkin J, Keeley FX. Indwelling catheter-associated urinary tract infections. Br J

Community Nursing 2003; 8:166-7, 170-1.

37. Collins JW, Keeley FX Jr, Timoney A. Cost analysis of flexible ureterorenoscopy.

BJU Int. 2004; 93(7):1023-6.

38. Thomas A, Keeley FX. Multiple bladder stones. Images in Clinical Medicine, in

Minerva. British Medical Journal 2004; 328:176.

39. Keoghane SR, Keeley FX, Timoney AG, Browning A, Tolley DA, Joyce A,

Downey P. The BAUS Section of Endourology audit of laparoscopic

nephrectomy. BJU Int, 2004, 94(4):577-81

40. Davenport K, Timoney AG, Keeley FX. A review of conventional and alternative

methods for providing analgesia in renal colic. BJU Int, 2005; 95(3):297-300.

41. Davenport K, Keeley FX. Evidence for the use of silver-alloy-coated urethral

catheters. J Hosp Infect. 2005; 60(4):298-303.

42. Collins JW, MacDermott S, Bradbrook RA, Keeley FX Jr., Timoney AG. A

comparison of the effect of 1.5% glycine and 5% glucose irrigants on plasma

serum physiology and the incidence of transurethral resection syndrome during

prostate resection. BJU Int. 2005; 96(3):368-72.

43. Davenport K, Minervini A, Timoney AG, Keeley FX. Our experience with

retroperitoneal and transperitoneal laparoscopic pyeloplasty for pelvi-ureteric

junction obstruction. Eur Urol 2005; 48:973-7.

44. Davenport K, Timoney AG, Keeley FX Jr, Joyce AD, Downey P. A 3-year review

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of The British Association of Urological Surgeons Section of Endourology

Laparoscopic Nephrectomy Audit. BJU Int. 2006; 97: 333-7.

45. Minervini A, Davenport K, Keeley FX Jr, Timoney AG. Antegrade versus

retrograde endopyelotomy for pelvi-ureteric junction (PUJ) obstruction. Eur Urol

2006; 49: 536-42

46. Collins JW, MacDermott S, Bradbrook RA, Keeley FX Jr., Timoney AG. Is using

ethanol-glycine irrigating fluid monitoring and 'good surgical practice' enough

to prevent harmful absorption during transurethral resection of the prostate?

BJU Int 2006; 97: 1247-51.

47. Davenport K, Keeley FX Jr, Timoney AG. A comparative in vitro study to

determine the beneficial effect of calcium-channel and alpha(1)-adrenoceptor

antagonism on human ureteric activity. BJU Int 2006; 98: 651-5.

48. Collins JW, MacDermott S, Bradbrook RA, Keeley FX Jr., Timoney AG. The effect

of the choice of irrigation fluid on cardiac stress during transurethral resection of

the prostate. A comparison between 1.5% glycine and 5% glucose. J Urol. 2007;

177: 1369-73.

49. Davenport K, Minervini A, Keoghane S, Parkin J, Keeley FX, Timoney AG. Does

rate matter? The results of a randomized controlled trial of 60 versus 120 shocks

per minute for shock wave lithotripsy of renal calculi. J Urol. 2006; 176: 2055-8;

discussion 2058.

50. Nabi G, Downey P, Keeley F, Watson G, McClinton S. Extra-corporeal shock

wave lithotripsy (ESWL) versus ureteroscopic management for ureteric calculi.

Cochrane Database Syst Rev. 2007;(1): CD006029.

51. Painter DJ, Timoney AG, Denton K, Alken P, Keeley FX Jr. The modern

management of upper urinary tract urothelial cancer: tumour diagnosis, grading

and staging. BJU Int. 2007; 99: 973-7.

52. Arancibia MF, Bolenz C, Michel MS, Keeley FX Jr., Alken P. The modern

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management of upper tract urothelial cancer: surgical treatment. BJU Int. 2007;

99: 978-81.

53. Davenport K, Timoney AG, Keeley FX Jr. Effect of smooth muscle relaxant drugs

on proximal human ureteric activity in vivo: a pilot study. Urol Res. 2007; 35:

207-13.

54. Keeley FX Jr., Rimington PD, Timoney AG, McClinton S. British Association of

Urological Surgeons laparoscopic mentorship guidelines. BJU Int 2007; 100: 247-

8.

55. Keeley FX Jr., Eden CG, Tolley DA, Joyce AD. The British Association of

Urological Surgeons: guidelines for training in laparoscopy. BJU Int. 2007; 100:

379-81.

56. Harryman O, Khastgir J, Keeley FX. Endourological Management of Ureteric

Obstruction Secondary to Candida Bezoar in a Transplant Kidney. Curr

Urol 2007; 1: 48-49.

57. Arumainayagam N, Minervini A, Davenport K, Kumar V, Masieri L, Serni S,

Carini M, Timoney AG, Keeley FX Jr. Antegrade versus Retrograde Stenting in

Laparoscopic Pyeloplasty. J Endourol 2008; 22: 671-4.

58. Williams SK, Denton KJ, Minervini A, Oxley J, Khastigir J, Timoney AG, Keeley

FX Jr. Correlation of upper-tract cytology, retrograde pyelography, ureteroscopic

appearance, and ureteroscopic biopsy with histologic examination of upper-tract

transitional cell carcinoma. J Endourol 2008; 22: 71-6.

59. Painter DJ, Denton K, Timoney AG, Keeley FX. Ureteroscopic management of

upper-tract urothelial cancer: an exciting nephron-sparing option or an

unacceptable risk? J Endourol. 2008; 22: 1237-40.

60. Giannarini G, Valent F, Keeley FX, Milesa C, Mogorovich, A; Manassero F,

Barbone F, Joshi HB, Timoney AG. The Italian Linguistic Validation of the

Ureteric Stent Symptoms Questionnaire. J Urol 2008; 180: 624-8.

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61. Minervini A, Davenport K, Pefanis G, Keeley FX Jr., Timoney AG. Prospective

study comparing the bladeless optical access trocar versus Hasson open trocar

for the establishment of pneumoperitoneum in laparoscopic renal procedures.

Arch It Urol Androl 2008; 80: 95-98.

62. Desai M, Hinck B, Keeley FX, Monga M. Terapeutická endourologie: obstrukce

ureteropelvické junkce. Urol List 2008; 6(3): 38–42.

63. Keeley FX, Hinck B, Desai M, Monga M. Terapeutická endourologie: karcinom z

p�echodných bun�k lokalizovaný v horních cestách mo�ových. Urol List 2008;

6(3): 48–53.

64. Gulur DM, Young JG, Painter DJ, Timoney AG, Keeley FX. How successful is the

conservative management of Pelvi-Ureteric Junction Obstruction (PUJO) in

adults? BJU Int. 2009; 103: 1414-6; discussion 1416.

65. Keeley FX Jr., Timoney AG, Rane A, Tolley DA. Mentorship in Urological

Laparoscopic Surgery: Lessons Learned. BJU Int. 2009; 103: 1111-3.

66. Harryman O, Davenport K, Keoghane SR, Keeley FX Jr., Timoney AG. A

Comparative Study of Quality of Life Issues Relating to Open versus

Laparoscopic Nephrectomy - Prospective Pragmatic Study. J Urol 2009; 181: 998-

1003; discussion 1003.

67. Keeley FX Jr, Assimos DG. Clinical trials of the surgical management of

urolithiasis: current status and future needs. Adv Chronic Kidney Dis. 2009; 16:

65-9.

68. Keeley FX Jr, Thornton M. Radiation safety: implications for urologists and

patients. J Urol 2009; 181: 443-4.

69. Crow P, Bayley J, Keeley F Jr. Smoking and urological disease. BJU Int 2009; 103:

1317-9.

70. Laguna MP, Beemster P, Kumar P, Klingler HC, Wyler S, Anderson C, Keeley

FX, Bachmann A, Rioja J, Mamoulakis C, Marberger M, de la Rosette JJ.

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Perioperative morbidity of laparoscopic cryoablation of small renal masses with

ultrathin probes: a European multicentre experience. Eur Urol 2009; 56: 355-61.

71. Gulur D, Crow P, Keeley FX. Minimally invasive ablative technique for the

treatment of small renal masses. Arch Ital Urol Androl 2009; 81: 100-6.

72. Liatsikos EN, Kallidonis P, Stolzenburg JU, Ost M, Keeley F, Traxer O, Bernardo

N, Perimenis P, Smith AD. Percutaneous Management of Staghorn Calculi in

Horseshoe Kidneys: A Multi-Institutional Experience. J Endourol. 2010; 24: 531-6.

73. Puichaud A, Larré S, Bruyère F, Auger J, Bret N, Chevreste A, Doré B, Briffaux R,

Keeley F, Irani J. [The French linguistic validation of the Ureteric Stent Symptom

Questionnaire (USSQ)] Prog Urol. 2010; 20: 210-3.

74. Crow P, Keeley FX. Prevention and handling of complications of renal focal

therapies. J Endourol. 2010; 24: 765-7.

75. Davenport K, Keeley FX Jr, Timoney AG. Audit of safety, efficacy, and cost-

effectiveness of local anaesthetic cystodiathermy. Ann R Coll Surg Engl. 2010; 92:

706-9.

76. Dellis A, Joshi HB, Timoney AG, Keeley FX Jr. Relief of stent related symptoms:

review of engineering and pharmacological solutions. J Urol 2010; 184: 1267-72.

77. Davenport K, Kumar V, Collins J, Melotti R, Timoney AG, Keeley FX Jr. New

Ureteral Stent Design Does Not Improve Patient Quality of Life: A Randomized,

Controlled Trial. J Urol 2011 185: 175-8.

78. Lallas CD, Pak RW, Pagnani C, Hubosky SG, Yanke BV, Keeley FX, Bagley DH.

The minimally invasive management of ureteropelvic junction obstruction in

horseshoe kidneys. World J Urol. 2011; 29: 91-5.

79. Giannarini G, Keeley FX Jr, Valent F, Manassero F, Mogorovich A, Autorino R,

Selli C. Predictors of morbidity in patients with indwelling ureteric stents: results

of a prospective study using the validated Ureteric Stent Symptoms

Questionnaire. BJU Int. 2011; 107: 648-54.

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80. Philippou P, Payne D, Keeley F. "Let's get it straight": the story of the spiral

ureter. Can J Urol. 2012; 19: 6118-20.

81. Aboumarzouk OM, Kata SG, Keeley FX, McClinton S, Nabi G. Extracorporeal

shock wave lithotripsy (ESWL) versus ureteroscopic management for ureteric

calculi. Cochrane Database Syst Rev. 2012 May 16;5:CD006029

82. Hotston MR, Keeley FX. Laparoscopic partial nephrectomy without ischemia.

Review. Arch Esp Urol 2013; 66: 146-51.

83. Calvert RC, Wong KY, Chitale SV, Irving SO, Nagarajan M, Biyani CS, Browning

AJ, Young JG, Timoney AG, Keeley FX, Burgess NA. Multilength or 24 cm

ureteric stent? A multicentre randomised comparison of stent-related symptoms

using a validated questionnaire. BJU Int. 2013; 111: 1099-104.

84. Philippou P, Payne D, Davenport K, Keeley FX, Timoney AG. Does previous

failed ESWL have a negative impact of on the outcome of ureterorenoscopy? A

matched pair analysis. Urolithiasis 2013; 41: 531-8.

85. Vannahme M, Mathur S, Davenport K, Timoney AG, Keeley FX. The

management of secondary pelvi-ureteric junction obstruction – A comparison of

pyeloplasty and endopyelotomy. BJU Int 2014; 113: 108-112.

86. Sanguedolce F, Millán-Rodriguez F, Santillana-Altimira JM, Fantova-Alonso A,

Sánchez-Martín FM, Angerri-Feu O, Lopez Martinez JM, Keeley FX, Joshi HB,

Villavicencio-Mávrich H. The Spanish Linguistic Validation of the Ureteral Stent

Symptom Questionnaire. J Endourology 2014; 28: 237-42.

87. Dellis AE, Keeley FX Jr, Manolas V, Skolarikos AA. The role of alpha-blockers in

the treatment of stent-related symptoms. A prospective randomized control

study. Urology 2014; 83: 56-61.

88. de la Rosette J, Denstedt J, Geavlete P, Keeley F, Matsuda T, Pearle M, Preminger

G, Traxer O; CROES URS Study Group. The clinical research office of the

endourological society ureteroscopy global study: indications, complications,

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and outcomes in 11,885 patients. J Endourol. 2014; 28: 131-9.

89. El-Nahas AR, Elsaadany MM, Tharwat M, Mosbah A, Metwally AH, Hawary A,

Keeley FX Jr, Sheir KZ. Validation of the Arabic linguistic version of the Ureteral

Stent Symptoms Questionnaire. Arab J Urol. 2014; 12(4): 290-3.

90. Henderson JM, Fowler S, Joyce A, Dickinson A, Keeley FX; BAUS. Perioperative

Outcomes of 6042 Nephrectomies in 2012: Surgeon-reported results in the United

Kingdom from the BAUS Nephrectomy Database. BJU Int. 2015 ; 115 : 121-6.

91. Hadjipavlou M, Khan F, Fowler S, Joyce A, Keeley FX, Sriprasad S. Partial vs

radical nephrectomy for T1 renal tumours: an analysis from the British

Association of Urological Surgeons Nephrectomy Audit. BJU Int. 2015; Mar 6.

doi: 10.1111/bju.13114.

92. Henderson JM, Fabricius MJ, Fowler S, Keeley FX, Dickinson A. The

complications of laparoscopic renal surgery: A review of 10 years of audit data in

the UK. J Clin Urol 2016: 9: 23-31.

Invited articles and Letters:

1. Keeley FX Jr, Tolley DA. Techniques of endopyelotomy. (Letter) Br J Urol Int

83: 879, 1999.

2. Joshi HB; Stainthorpe A; Keeley FX. Re: Incorporation of patient preferences

in the treatment of upper urinary tract calculi: a decision analytical view

(letter). J Urol 2000; 164(2): 460

3. Kumar PV; Keeley FX; Timoney AG. Re: Retrograde ureteropyeloscopy for

lower pole caliceal calculi (letter). J Urol 2000; 164(4): 1318

4. Painter DJ; Keeley Jr FX. New concepts in the treatment of ureteral calculi.

Curr Opin Urol 2001;11:373-8

5. Keeley FX Jr. Editorial Comment on: Finelli A, Honey RJ. Thoracoscopy-

assisted high intercostal percutaneous renal access. J Endourol. 2001; 15: 581-

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4; discussion 584-5.

6. Keeley FX. Contemporary trends in laparoscopic urologic surgery (book

review). BJU Int. 2002; 90:766.

7. Keeley FX. How to choose a flexible ureteroscope. Urology News 2002.

8. Keeley FX; Keoghane SR. Training in laparoscopic urology: How to get

started. Urology News 2003.

9. Keeley FX, Jr. Editorial Comment on Carini M, Minervini A, Masieri L,

Lapini A, Semi S. Simple enucleation for the treatment of PT1a renal cell

carcinoma: our 20-year experience. Eur Urol 2006; 50: 1263-8; discussion

1269-71.

10. Keeley FX Jr., Timoney AG. Routine stenting after ureteroscopy: think again.

Eur Urol. 2007; 52: 642-4.

11. Keeley FX Jr. Editorial Comment on: Jain A, Shah TK. Effect of air bubbles in

the coupling medium on efficacy of extracorporeal shock wave lithotripsy.

Eur Urol 2007; 51: 1680-6; discussion 1686-7.

12. Giannarini G, Mogorovich A, Selli C, Keeley FX Jr. Re: Indwelling ureteral

stents and sexual health: a prospective, multivariate analysis. M. C.

Sighinolfi, S. Micali, S. De Stefani, A. Mofferdin, M. Grande, M. Giacometti,

N. Ferrari, M. Rivalta and G. Bianchi. J Urol 2007; 178: 229-231 (letter).

13. Rané A, Eng MK, Keeley FX Jr. Port site metastases. Curr Opin Urol 2008; 18:

185-9.

14. Rane A, Keeley FX Jr. Is robotically assisted laparoscopic pyeloplasty

effective for the treatment of pelvi-ureteric junction obstruction? Nat Clin

Pract Urol 2008.

15. Paterson RF, Matsuda T, Marcovich R, Patel A, Tiselius HG, Keeley FX Jr,

Michel MS, Lee DI. Survey of endourology. J Endourol 2008; 22: 231-42.

16. Crow P, Keeley FX. Does the rate of shock wave delivery affect outcomes in

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patients receiving shock wave lithotripsy for urinary calculi? Nature Clin

Prac Urol. 2008; 5: 478-9.

17. Giannarini G, Mogorovich A, Selli C, Keeley FX Jr. Letter to the Editor Re:

Indwelling ureteral stents and sexual health: a prospective, multivariate

analysis. J Urol. 2008; 180: 1188-9.

18. Kumar V, Keeley FX Jr. Percutaneous nephrolithotomy: why do we use rigid

dilators? J Endourol 2008; 22: 1877-9; discussion 1885, 1889.

19. Keeley FX Jr, Minervini A. Editorial comment on Gabr AH, Gdor Y, Strope

SA, Roberts WW, Wolf JS Jr. Patient and pathologic correlates with

perioperative and long-term outcomes of laparoscopic radical nephrectomy.

Urology 2009; 74: 640-1; author reply 642.

20. Joshi HB, Keeley FX, Timoney AG. Re: a novel drug eluting ureteral stent: a

prospective, randomized, multicenter clinical trial to evaluate the safety and

effectiveness of a ketorolac loaded ureteral stent: A. E. Krambeck, R. S.

Walsh, J. D. Denstedt, G. M. Preminger, J. Li, J. C. Evans and J. E. Lingeman J

Urol 2010; 183: 1037-1043. J Urol. 2010 Nov;184(5):2217-8; author reply 2218.

21. Keeley FX Jr. Editorial comment. Jeon HG, Lee SR, Kim KH, Oh YT, Cho NH,

Rha KH, Yang SC, Han WK. Benign lesions after partial nephrectomy for

presumed renal cell carcinoma in masses 4 cm or less: prevalence and

predictors in Korean patients. Urology 2010 Sep; 76(3): 579.

22. Phipps S, Tolley DA, Young JG, Keeley FX Jr. The management of ureteric

stones (invited manuscript). Ann R Coll Surg Engl 2010 Jul; 92(5): 368-72.

23. Keeley FX Jr. Editorial comment. Comment on Benign lesions after partial

nephrectomy for presumed renal cell carcinoma in masses 4 cm or less:

prevalence and predictors in Korean patients. Urology 2010 Sep; 76(3): 579.

24. Joshi HB, Keeley FX, Timoney AG. Editorial comment. Re: a novel drug

eluting ureteral stent: a prospective, randomized, multicenter clinical trial to

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evaluate the safety and effectiveness of a ketorolac loaded ureteral stent: A.

E. Krambeck, R. S. Walsh, J. D. Denstedt, G. M. Preminger, J. Li, J. C. Evans

and J. E. Lingeman J Urol 2010; 183: 1037-1043. J Urol. 2010 Nov;184(5):2217-

8; author reply 2218.

25. Keeley FX Jr. Endoscopic biopsy of upper tract tumors: why bother? Can J

Urol. 2012 Dec;19(6):6566.

26. Keeley FX Jr. Stent placement under local: too painful to be practical? Can J

Urol. 2014; 21: 71.

27. Keeley FX Jr. Global CROES Ureteroscopy Registry Demonstrates Striking

Cooperation Among Endourologists. Eur Urol. 2014; 66: 110-1.

28. Keeley FX Jr. Public reporting of individual surgeons' outcomes in the UK.

Can J Urol. 2014; 21: 7429.

Chapters:

1. Keeley FX, Gill IS, and Gomella LG. Laparoscopic preperitoneal

lymphadenectomy. In: Textbook of Endourology. Editors: Sosa, Jenkins,

Perlmutter, and Albala. W.B. Saunders. Chapter 31, pp 505-510; 1996.

2. Keeley FX and Gomella LG. Epidemiology of Prostate Cancer. In: Urologic

Cancers. Ernstoff MS, Heaney JA, and Peschel RE (eds). W.W. Norton, New

York. Chapter 1, p.1, 1997.

3. Keeley FX, Jr. and Tolley DA. Stone disease and minimally invasive surgery.

In: Urology Highlights, 1996. Shah J (ed.). Healthcare Press. p 74-79, 1997.

4. Keeley FX, Jr., Tolley DA. Stone disease and minimally invasive surgery. In:

Urology Highlights, 1997. Shah J (ed.). Healthcare Press. p 76-82, 1998.

5. Keeley FX Jr., Tolley DA. Extracorporeal shock wave lithotripsy of renal

calculi. In Vaughn ED, Perlmutter A, Marberger M, An Atlas of Urology. In

press, 1999.

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6. Keeley FX, Jr., Tolley DA. Stone disease and minimally invasive surgery. In:

Urology Highlights, 1998-99. Shah J (ed.). Healthcare Press. p 81-87, 1999.

7. Keeley FX, Kumar PVS. Urinary stone disease: upper urinary tract

obstruction. In: ‘Essential Surgical Practice’. (Eds) Sir Alfred Cuschieri, Prof

Robert JC Steele and Prof AR Moosa. Arnold, 2002: 1269-1281

8. Keoghane SR, Keeley FX. Laparoscopic Management of Calculus Disease. In

Glenn’s Operative Urology, 6th Edition, Laparoscopy Section, Leonard G.

Gomella, Section Editor.

9. Keeley FX. Ureteral stones in pregnancy. In WHO Consultation on Stone

Disease, 2002.

10. Keeley FX. Medullary sponge kidney. In 5-Minute Urology Consult. Editor

Leonard G. Gomella, Lippincott Williams & Wilkins, 2000.

11. Keeley FX. Pneumaturia. In 5-Minute Urology Consult. Editor Leonard G.

Gomella, Lippincott Williams & Wilkins, 2000.

12. Dickerson D, Keeley FX. Penile and upper urinary tract cancer. In The year in

urology 2002.

13. Timoney AG, Keeley FX. Urolithiasis and endourology. In The year in

urology 2002.

14. Keeley FX, Timoney AG, Schwaibold H. Laparoscopy and robots. In The year

in urology 2002.

15. Goh M, Keeley FX. Laparoscopic radical prostatectomy. In The year in

urology 2003.

16. Davenport K, Keeley FX. Diagnostic Ureteroscopy. In Smith’s Textbook of

Endourology, 2nd edition.

17. Harryman O, Keeley FX Jr. Stones in Pregnancy. In WHO Consultation on

Stone Disease, 2008.

18. Young JG, Keeley FX Jr. Transabdominal Pyeloplasty. In Essentials of

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Pediatric Endoscopic Surgery. Eds. Amulya K. Saxena and Michael

E. Höllwarth. Springer Berlin Heidelberg 2008. pp. 409-413.

19. Chua WJ, Keeley FX. Endometriosis affecting the urinary tract. In

Laparoscopic Surgery for Benign Gynaecology. 2011. Edited by Sanjay Vyas.

20. Goh MHC, Pellatt RA, Keeley FX. Transitional Cell Cancer. In Ureteroscopy:

Indications, Instrumentation, and Technique. 2012. Edited by Manoj Monga.

21. Hotston M, Keeley FX. Upper tract TCC epidemiology. In Percutaneous

Renal Surgery edited by Manoj Monga. 2013

22. Mathur S, Keeley FX. Stenting. Urinary Stones: Medical and Surgical

Management (edited by Michael Grasso and David Goldfarb). 2013.

23. John Michael Henderson and Francis X. Keeley Jr . Topical Chemotherapy. In

Upper Urinary Tract Urothelial Carcinoma. Edited by Michael Grasso III and

Demetrius H Bagley. Springer, 2015.

BOOK EDITOR

1. Rane A, Keeley FX Jr., Painter D. Top Tips in Laparoscopic Urology. 2007

Euromed Communications, Surrey, England.

2. Rane A, Desai M, Monga M, Keeley FX Jr. Top Tips in Endourology. 2008

Euromed Communications, Surrey, England.

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RESEARCH GRANTS

• Successful application to the Southmead Hospital Research Foundation

(£7,000) for the assessment of quality of life in patients with ureteral stents.

• Successful submission to the Southmead Hospital Research Foundation to

continue collecting follow-up data from the MRC Asymptomatic Kidney

Stone Study (£7,000).

• Successful application to Bard Ltd (£30,000) for the development of a multi-

dimensional questionnaire to assess patients’ symptoms related to ureteral

stents.

• Participation in a multicenter study of stent-related symptoms sponsored by

Microvasive/Boston Scientific (£3,000).

• Alpha blocker (Tamsulosin) versus placebo randomized controlled trial.

Supported by Astellas Pharmaceuticals. Adopted by the National Institute

for Health Research (NIHR).

• Co-applicant for successful National Institute for Health Research Health

Technology Assessment Grant, CONSERVE, comparing surgery with needle

ablation in the treatment of small renal masses.

• Co-applicant for successful National Institute for Health Research Health

Technology Assessment Grant, SUSPEND, comparing calcium channel

blocker and alpha blocker to placebo in the management of ureteric stones.

Member of the Trial Steering Committee.

• Co-applicant for successful National Institute for Health Research Health

Technology Assessment Grant, POUT, comparing chemotherapy to standard

care for patients with invasive upper tract transitional cell carcinoma.

Member of the Trial Management Group.

• Co-applicant for National Institute for Health Research Health Technology

Assessment Grant, TISU, comparing ureteroscopy to shock wave lithotripsy

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for ureteric stones.

• Co-applicant for successful National Cancer Research Institute Grant, UK

Active Surveillance Study for Small Renal Masses.

• EuRECA, the European Renal Cryoablation Registry. Grant for £125,000 from

Galil Medical.

RESEARCH

My research activity includes the following aspects of upper urinary tract disorders:

• The qualitative aspects of surgeon-reported outcomes.

• Cryoablation and partial nephrectomy in the treatment of kidney tumors.

• The diagnosis and minimally invasive management of upper urinary tract

transitional cell carcinoma.

• The evaluation and treatment of ureteropelvic junction obstruction.

• The development of new techniques in laparoscopic urological surgery.

• The minimally invasive management of stone disease.

• The investigation of mechanisms responsible for stone fragmentation from

extracorporeal shock wave lithotripsy (SWL).

• The role of anatomic factors in stone clearance following SWL.

• Comparison of irrigating fluids during TURP.

• Endoluminal ultrasound in the evaluation of UPJ obstruction and the staging

of upper tract transitional cell carcinoma.

• The quality of life of patients with urinary stone disease, especially in

patients requiring ureteral stents.

• The evaluation of ureteral physiology and pharmacology.

• The evaluation of medical expulsive therapy for ureteral stones.

Current research projects include:

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• The qualitative aspects of surgeon-reported outcomes.

• Cryoablation of kidney tumors as part of a European cryoablation registry

(EuRECA). I serve as chair of the Steering Committee.

• Analysis of predictive factors for complications following nephrectomy.

• Management of patients with failed previous treatment for PUJ obstruction.