Fostering Biotechnology Fostering Biotechnology Fostering Biotechnology Fostering Biotechnology at National at National at National at National

Tsing Hua University Tsing Hua University Tsing Hua University Tsing Hua University ---- Current Current Current Current

Approach and PerspectiveApproach and PerspectiveApproach and PerspectiveApproach and Perspective

Hwan You Chang

Office of Research and Development, NTHU

General information of NTHU

650 faculty members 12,000 students7 collegesScience (1974) Engineering (1974) Nuclear Science (1974) Humanities and Social Science (1984) Life Science (1992) General Education (1995) Electric Engineering and Computer Science (1998)Technology Management (2000)

15 Interdisciplinary research centers~150 Labs on Bio-related projects

HsinChu Train

station

HSRS

MiaoLi

TaipeiTaipei

Taichung

TaoYuan Intl Airport

High-speed Computer Center

Synchrotron Radiation Center

National Health Research Inst

Agriculture Technology Research Inst

Science Park

NCTU

NTHU

ITRI

Hsin-Chu High Tech Zone

Industrial Tech Res Inst

Space Research Center

Nano Device Lab,

HsinChu

Biomedical

Park/SI2C

Education of Entrepreneurship at NTHU

• Courses (e.g., Biotech product realization practice, Patent law, Business plan writing, etc…)

• Industry-campus events

Student entrepreneur day &

entrepreneurship award

Scholarship and summer internship

Industry-NTHU joint research programs

Industry mentors

Campus recruitment

• Tsing Hua Dormitory College – Innovation ideas

Admission

EducationCultivation

Dedication

育成中

育成中

育成中

育成中

心心 心心

Future leaders

Education

Industry

engagement

Brilliant facultyInterdisciplinary

curriculum

Diversified

admissions

Alumni

mentoring

Education

dynamics

Bilingual

courses

Tsing Hua

Dormitory

College

Prospective students

Biomedical Research Center

BioMedicalBioMedicalBioMedicalBioMedical Research CenterResearch CenterResearch CenterResearch Center

Office Office Office Office of Research and Developmentof Research and Developmentof Research and Developmentof Research and Development

Core Research TopicCore Research TopicCore Research TopicCore Research Topic Core facilityCore facilityCore facilityCore facility Administration Support Administration Support Administration Support Administration Support Lab Animal CenterLab Animal CenterLab Animal CenterLab Animal Center

ZebraFishZebraFishZebraFishZebraFish Core facilityCore facilityCore facilityCore facility

Molecular Imaging FacilityMolecular Imaging FacilityMolecular Imaging FacilityMolecular Imaging Facility

Proteomics/Genomics Proteomics/Genomics Proteomics/Genomics Proteomics/Genomics FacilityFacilityFacilityFacility

Clinical Hospital Research Clinical Hospital Research Clinical Hospital Research Clinical Hospital Research Collaboration Collaboration Collaboration Collaboration

Academic Workshop Academic Workshop Academic Workshop Academic Workshop

Regenerative medicineRegenerative medicineRegenerative medicineRegenerative medicine

Preventive medicinePreventive medicinePreventive medicinePreventive medicine

Personalized medicinePersonalized medicinePersonalized medicinePersonalized medicine

The Operation Center for Industry Collaboration (OCIC)

Office R&D

OCIC

Admin. core

Promotion, engagement, admin., web service

IP Licensing Tech Transfer

Patent apply, maintain, tech transfer

Incubation Center

Office leasing, Government resource link, Biz consulting

Germination Center

Pre-venture, Tech survey, commercialization study

Joint research partners

Optical OE Energy ITBio medicalElectronics

International collaborations

• ~ 200 sister universities

• Commercial Institutes• Microsoft• INTEL• GE • Boeing

• Government institutions• US Cold Spring Harbor Lab• Air Force Office of Scientific Research (AFOSR)• Association of Research Libraries (ARL)• Argonne National Laboratory (ANL)

Key Performance of OCIC• IP management

• Ranked 15th university in the world on US patent granted

(2013, US National Academy of Inventors’ survey)

• Taiwan Innovation Award (2012,Thomson Reuters)

• Germination Center (from 2011)

• Support 18 teams (>100 students) venture to form startups• Incubation Center

• 2010-3 best incubator award (Ministry of Economic Affairs)• Foster > 100 companies (1.2 billion USD)

New NTHU Innovation Incubator Building

A 9-story building, ~ 20,000 m2

Linked to the Tsing Hua Laboratory Building.

Includes coworking space, multi-function exhibition hall, meeting

rooms, etc.

Future Directions of Academic-Industry

Collaboration at NTHU

Meeting the needs of startups

• Globalization

• Vertical integration

• Rapid prototyping service

Focus on

• Internet-of-Things

• Biomedical Technology

Globalization for startupsGlobalization for startupsGlobalization for startupsGlobalization for startups

Domestic and international; Both ways

Connecting to sister universities/institutions abroad

• Assist local patent application and licensing

• Provide operation space

• Local law and government administration consultations

• Local sale channels

• Connect manufacturing capability of Taiwan

Meeting the needsMeeting the needsMeeting the needsMeeting the needs

• Identification of and providing the missing elements

A. Uncertain technology applications and market needs

Experienced mentors; industrial alliance (e.g., microfluidics)

B. Slow and expensive prototyping process

Connect to the strong manufacturing capability of Taiwan

Establish a New Product Introduction (NPI) mechanism

Project Management

• Based on:

NTHU R&D strength

Local environment

Investment atmosphere

• Some topics:

Biomedical imaging, Molecular diagnostics, Biosensors, Medical devices

Both reagents and systems are considered

Medical devices and diagnostics as the beginning

Ub

K

E

Int

S

C

Int

Int

Vertical Integration of Biotech Development

Chain

Tsing Hua Biotech

Accelerator

Innovation Club

Acceleration

service

Clinical

Trial IRB

Business

Develop &

Promotion

Operation Core

Research

Lab /

Alliances

Administrat

ion support

VC club

Alumni

Industrial

mentors

NTHU

Bioethics

Office

Animal

room

Hospitals

and CROs

Reagent

Supply &

Device

prototyping

Acceleration Service for Biotech Startups

I. Establish facility and connection to

• Education and training- Technology, Business, Law, etc.

• Screening systems (mAb, aptamer, phage display)

• Small-scale production and purification of reagents (recombinant proteins; Ag/Ab; nanoparticles; etc.)

• Device, softwares and system prototyping and testing

II. Seed fund raising and sustainable development

創新產品的專案管理 (NPI)

創新產品的原型製造整合管理產業國際鏈結與全球行銷

產業新創事業與風險投資的加入

Early investment fromGovernmentAcceleration mechanism

Establish Seed Fund

(Starting +Feedback )

New Product

Introduction and

Project

Management

Attract more

resources, Service

upgrade

Manufacturing and

chain integration

Global

Connection

& Marketing

Offer Offer Offer Offer solutions for improvingsolutions for improvingsolutions for improvingsolutions for improving last last last last

milemilemilemile availabilityavailabilityavailabilityavailability for biotech startupsfor biotech startupsfor biotech startupsfor biotech startups