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Page 1: Foodborne illness in Australia - Department of Health · Foodborne illness in Australia circa 2010 7 Executive summary Foodborne illness causes significant morbidity and occasional

Foodborne illness in Australia

Annual incidence circa 2010

Page 2: Foodborne illness in Australia - Department of Health · Foodborne illness in Australia circa 2010 7 Executive summary Foodborne illness causes significant morbidity and occasional

2

Foodborne illness in Australia: Annual incidence circa 2010

Authors: Martyn Kirk, Kathryn Glass, Laura Ford, Kathryn Brown and Gillian Hall, National Centre for Epidemiology and Population Health, Australian National University.

Prepared for the Australian Government Department of Health, New South Wales Food Authority and Food Standards Australia New Zealand by the National Centre for Epidemiology and Population Health, Australian National University.

Online ISBN: 978-1-74186-170-9

Publications approval number: 10768

© Commonwealth of Australia 2014

This work is copyright. You may download, display, print and reproduce the whole or part of this work in unaltered form for your own personal use or, if you are part of an organisation, for internal use within your organisation, but only if you or your organisation do not use the reproduction for any commercial purpose and retain this copyright notice and all disclaimer notices as part of that reproduction. Apart from rights to use as permitted by the Copyright Act 1968 or allowed by this copyright notice, all other rights are reserved and you are not allowed to reproduce the whole or any part of this work in any way (electronic or otherwise) without first being given the specific written permission from the Commonwealth to do so. Requests and inquiries concerning reproduction and rights are to be sent to the Communication Branch, Department of Health, GPO Box 9848, Canberra ACT 2601, or via e-mail to [email protected].

Front cover images Images by CDC (Melissa Brower, Dawn Arlotta and Mary Anne Fenley) and Katrina Knope.

Page 3: Foodborne illness in Australia - Department of Health · Foodborne illness in Australia circa 2010 7 Executive summary Foodborne illness causes significant morbidity and occasional

3Foodborne illness in Australia circa 2010

ContentsGlossary and acronyms ................................................................................................................................ 4

Executive summary ....................................................................................................................................... 7

Acknowledgements ...................................................................................................................................... 8

Introduction ................................................................................................................................................... 8

Aims ............................................................................................................................................................. 10

Comparing foodborne illness internationally ............................................................................................ 11

Methods ....................................................................................................................................................... 15

Results .......................................................................................................................................................... 21

Discussion .................................................................................................................................................... 30

Conclusion .................................................................................................................................................. 35

Technical Appendix 1: Further comparing foodborne illness internationally .......................................... 37

Technical Appendix 2: National gastroenteritis survey II ........................................................................... 45

Technical Appendix 3: Data sources ......................................................................................................... 52

Technical Appendix 4: Approaches for calculating community incidence ........................................... 54

Technical Appendix 5: Multipliers ............................................................................................................... 56

Technical Appendix 6: Other methods to estimate incidence ................................................................ 63

Technical Appendix 7: Hospitalisations and deaths methods ................................................................. 64

Technical Appendix 8: Methods for sequelae incidence ......................................................................... 70

Technical Appendix 9: Methods to estimate hospitalisations and deaths due to sequelae ................. 74

Technical Appendix 10: Comparison with estimates circa 2000 ............................................................. 79

Technical Appendix 11: Pathogen and illness sheets ............................................................................... 80

References ................................................................................................................................................. 110

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GLOSSARY AND ACRONYMS

Asymptomatic A state where a person who is infected does not show any symptoms.

GBS Guillain-Barré syndrome – a disorder where the body’s immune system attacks the peripheral nervous system and may be the result of a preceding infectious event.

CI Confidence interval – represents a range of values that act as good estimates for an unknown parameter using a frequentist distribution.

CrI Credible interval – represents a range of values where the most likely estimate might lie using a posterior probability distribution. It may be interpreted similar to confidence intervals.

DALY Disability adjusted life year – a metric to describe the burden of disease that takes into account the morbidity and mortality of a condition.

Delphi process A method for structuring a group communication process so that the process is effective in allowing a group of individuals, as a whole, to deal with a complex problem.

Foodborne illness Any illness resulting from the consumption of contaminated food, pathogenic bacteria, viruses or parasites that contaminate food.

HUS Haemolytic uraemic syndrome – a disorder where blood cells are destroyed injuring the kidneys; often occurring following infection with toxin-producing bacteria.

IBS Irritable bowel syndrome – chronic abdominal pain, bloating, constipation and diarrhoea; often triggered as the result of bacterial gastroenteritis.

ICD-10-AM International Statistical Classification of Diseases and Related Health Problems, Tenth Revision, Australian Modification.

IID2 The second longitudinal study of infectious intestinal disease in the United Kingdom by Tam et al.1

Incidence The rates at which new cases occur in a population in a specific time period.

Monte Carlo simulation

A computerised mathematical technique that performs risk analysis by building models of possible results by substituting a probability distribution for any factor that has inherent uncertainty and producing distributions of possible outcome values.

Notifiable An infection that doctors, laboratories, or other health professionals must report or notify to health departments for the purpose of prevention and control.

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5Foodborne illness in Australia circa 2010

NGSI National Gastroenteritis Survey I – a nationally representative cross-sectional survey conducted in Australia in 2001–2002.

NGSII National Gastroenteritis Survey II – a nationally representative cross-sectional survey conducted in Australia in 2008–2009.

NNDSS National Notifiable Diseases Surveillance System – the national system of surveillance for infectious diseases in Australia.

OzFoodNet An Australian network for enhanced surveillance of foodborne disease established by the Australian Government Department of Health in 2000 with Australia’s state and territory health authorities. OzFoodNet investigates multi-jurisdictional outbreaks of disease, provides understanding of the causes and incidence of foodborne disease in the community, and provides evidence for policy formulation.

OzFoodNet outbreak register

A register of data on outbreaks of gastrointestinal and foodborne diseases that was established in 2000.

Prevalence The proportion of the population that has a condition at a given point in time, including new and chronic cases of disease.

ReA Reactive arthritis – arthritis following bacterial infection; previously known as Reiter’s syndrome.

STEC Shiga toxin-producing Escherichia coli – strains of E. coli producing Shiga toxins, which may result in haemolytic uraemic syndrome.

WQS Water Quality Study – A randomised controlled trial conducted in Melbourne in 1997–1999 to examine whether reticulated water meeting national guidelines resulted in gastroenteritis by Hellard et al.2

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Page 7: Foodborne illness in Australia - Department of Health · Foodborne illness in Australia circa 2010 7 Executive summary Foodborne illness causes significant morbidity and occasional

7Foodborne illness in Australia circa 2010

Executive summaryFoodborne illness causes significant morbidity and occasional mortality in Australia. Reports of disease outbreaks linked to contaminated food are common and may result in damage to specific food businesses, related food businesses and whole industries. Lost productivity, impacts on lifestyle and medical expenses from foodborne illness can result in a substantial burden for Australia. The costs of foodborne illness highlight the need to improve efforts to prevent disease and strengthen food safety.

Understanding the epidemiology of diseases that occur as a result of contaminated food is complicated, as there are many different agents that can cause illness. While the majority of foodborne pathogens cause gastroenteritis, there are some that result in different illnesses, such as meningitis and hepatitis. Only a fraction of cases of foodborne illness are reported to health departments and investigated, and for many diseases it is not mandatory for doctors and laboratories to report cases to health departments for investigation. It is necessary to use novel methods and analyse multiple datasets to estimate incidence and outcome of foodborne illness, including notifiable disease reports, laboratory data, outbreak surveillance reports, expert opinion and the literature.

This report estimates the number of cases of illness and common sequelae acquired in Australia from contaminated food, circa 2010. It also estimates the number of hospitalisations and deaths due to foodborne illnesses and sequelae. Uncertainty in the data is accounted for by reporting 90% Credible Intervals (CrI) and comparing estimates using different sources of data and over time.

Circa 2010, there were an estimated annual 4.1 million (90% CrI: 2.3–6.4 million) cases of foodborne gastroenteritis acquired in Australia, along with 5,140 (90% CrI: 3,530–7,980) cases of non-gastrointestinal illness and 35,840 (90% CrI: 25,000–54,000) cases of sequelae. Norovirus, pathogenic Escherichia coli, Campylobacter spp. and non-typhoidal Salmonella spp. were the most common known causes of foodborne gastroenteritis, although approximately 80% of illnesses are of unknown pathogens. Approximately 25% (90% CrI: 13%–42%) of the 15.9 million episodes of gastroenteritis that occur in Australia were estimated to be transmitted by contaminated food. This equates to an average of approximately one episode of foodborne gastroenteritis every five years per person. Data on the number of hospitalisations and deaths represent the occurrence of serious foodborne illness. Including gastroenteritis, non-gastroenteritis and sequelae, there were an estimated annual 31,920 (90% CrI: 29,500–35,500) hospitalisations due to foodborne illness and 86 (90% CrI: 70–105) deaths due to foodborne illness circa 2010.

A main aim of this study was to compare if foodborne illness incidence had increased over time. In this study, similar methods of assessment were applied to data from circa 2000, which showed that the rate of foodborne gastroenteritis had not changed significantly over time. Two key estimates were the total number of gastroenteritis episodes each year, and the proportion considered foodborne. In circa 2010, it was estimated that 25% of all episodes of gastroenteritis were foodborne. By applying this proportion of episodes due to food to the incidence of gastroenteritis circa 2000, there were an estimated 4.3 million (90% CrI: 2.2–7.3 million) episodes of foodborne gastroenteritis circa 2000, although credible intervals overlap with 2010. Taking into account changes in population size, applying these equivalent methods suggests a 17% decrease in the rate of foodborne gastroenteritis between 2000 and 2010, with considerable overlap of the 90% credible intervals.

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For certain specific foodborne illnesses data were compared from 2000 and 2010 to examine whether they are increasing or decreasing. For example, foodborne salmonellosis was estimated to have increased from 28,000 annual infections circa 2000 to 39,600 annual infections circa 2010; a rate increase of 24% from 1,500 cases per million to 1,850 cases per million annually. Similarly, for foodborne campylobacteriosis there were 139,000 infections circa 2000, rising to 179,000 infections circa 2010; representing a 13% increase in incidence from 7,400 cases per million to 8,400 cases per million annually. Illnesses from hepatitis A decreased from 245 cases circa 2000 to 40 cases circa 2010, representing a rate decrease of 85% from 13 cases per million to two cases per million annually.

The findings of this study are similar to recent estimates in the United States of America (USA), Canada and other countries. These estimates take into account improvements in understanding foodborne illnesses and the agents responsible, improved information sources, and advances made in methodological approaches. Where possible, contemporary Australian data collected at or around 2010 were used.

The results of this study will improve the understanding of the epidemiology of specific pathogens and foodborne causes of gastroenteritis in Australia. This will assist in prioritising foodborne illness for intervention. It is important that Australian governments and industry work together to reduce the incidence of preventable foodborne illness and educate consumers about good hygiene and food safety strategies.

AcknowledgementsThe Australian Government Department of Health, New South Wales Food Authority and Food Standards Australia New Zealand would like to thank the many people who helped with the conduct of this study and the production of this report. This report was authored by Dr Martyn Kirk, Dr Kathryn Glass, Ms Laura Ford, Dr Kathryn Brown and Dr Gillian Hall of the National Centre for Epidemiology and Population Health, under contract to the commissioning agencies. The Communicable Diseases Network Australia provided data from the National Notifiable Diseases Surveillance System on notifications of infectious causes of gastroenteritis. State and territory health departments, public health laboratories and OzFoodNet epidemiologists also provided data used in this study. The commissioning agencies and the authors thank Drs Martha Sinclair and Karin Leder for providing Water Quality Study data for this study. This work was funded by the Australian Government Department of Health, New South Wales Food Authority and Food Standards Australia New Zealand.

IntroductionIn 2000, it was estimated that every Australian would experience an episode of gastroenteritis due to food every four years.3 The economic costs of foodborne illness are substantial from medical practitioner visits, antibiotic prescriptions and days of work lost each year. The total cost of foodborne illness in Australia is largely attributable to productivity and lifestyle costs, premature mortality and health care services.4 This, largely preventable, burden of foodborne illness to the Australian community highlights the need to continue to improve food safety in Australia.

This report represents an updated estimate of the incidence of foodborne illness in Australia, circa 2010. It is important to regularly update estimates for foodborne illnesses, due to improvements in methods of estimation and changing incidence of disease. There are many different influences on the incidence of foodborne illness, including:

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9Foodborne illness in Australia circa 2010

• new regulatory measures aimed at preventing infections;

• changing agricultural and manufacturing practices;

• trends in the way food is prepared, along with consumers’ food choices and changes in eating patterns;

• international distribution of food;

• emergence of new pathogens; and

• identification of new and emerging strains of common infectious agents, such as those that are resistant to antibiotics.

In order to ensure that the estimate of the incidence of foodborne illness in Australia is internationally comparable, the approach first used by Mead et al.5 and subsequently by Scallan et al.6 in the USA has been adopted. This approach entails determining the total amount of gastroenteritis in the country and secondly the proportion of gastroenteritis that is foodborne. The product of these two estimates gives the total number of cases of foodborne gastroenteritis. However, a slightly different list of pathogens to those used in the study by Scallan et al.6 has been selected including pathogens and illnesses of particular relevance to Australia. Additionally, this report estimates the incidence of sequelae occurring as a delayed reaction to episodes of acute gastroenteritis, such as reactive arthritis (ReA), irritable bowel syndrome (IBS), haemolytic uraemic syndrome (HUS) and Guillain-Barré syndrome (GBS).

There are many challenges associated with quantifying the true incidence of foodborne illness in the community. A wide variety of different pathogens produce symptoms of gastroenteritis. Often clinical cases of gastroenteritis are assessed as ‘presumed infectious’ and a pathogen is never identified, either because a stool test is not performed, the stool test fails to identify a known pathogen, or because the pathogen is totally unknown. Scallan et al.7 estimated that in the USA, 38.4 million (90% CrI: 19.8–61.3 million) episodes, or 80% of domestically acquired foodborne illness were caused by unspecified agents. Only a few decades ago, pathogens such as Campylobacter spp., Shiga toxin-producing Escherichia coli (STEC), and norovirus were completely unknown.3

One of the most uncertain areas is estimating what proportion of illnesses is due to contaminated food. Most of the pathogens included in this study may be transmitted to humans through contaminated foods or water, as well as from other infected persons, from the environment or from animals. To account for this, expert elicitation was used to estimate the proportion of illness thought to result from contaminated food.

Most cases of gastroenteritis are mild and self-limiting and most people do not visit a doctor or submit a specimen for testing. In Australia, state and territory health departments forward reports of gastrointestinal diseases such as campylobacteriosis, cryptosporidiosis, salmonellosis, STEC and shigellosis to the National Notifiable Diseases Surveillance System (NNDSS). However, if people suffering gastroenteritis do not visit a doctor or submit a specimen for testing their illness will not be recorded in either NNDSS or in state surveillance systems.

Not all foodborne illnesses are notifiable to health departments, for example campylobacteriosis is not notifiable in New South Wales (NSW), norovirus, which is one of the most common causes of gastroenteritis in the developed world, is not notifiable to the NNDSS and poisoning by ciguatera is only recorded in Queensland. Surveillance data represents only a small fraction of the total incidence and multipliers are devised to adjust for underreporting and incomplete population coverage in the Australian surveillance system as well as for infections acquired overseas. The uncertainty in estimates must be taken into consideration. The approach used in the current study was to quantify each component of uncertainty with a plausible probability distribution. Simulations of these distributions

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Page 10: Foodborne illness in Australia - Department of Health · Foodborne illness in Australia circa 2010 7 Executive summary Foodborne illness causes significant morbidity and occasional

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were then used to generate an interval that contains the credible estimates of the number of foodborne cases of gastroenteritis.

In this report, improvements in the understanding of foodborne illness and the agents responsible since circa 2000 are taken into account. Specifically, these estimates circa 2010 are based upon new data from:

• a review of the literature to determine the best methodological approaches to estimating foodborne illness;

• a nationally representative gastroenteritis survey conducted in 2008–9;

• updated estimates of underdiagnosis and underreporting of infectious foodborne illnesses to surveillance;

• an expert consultation to determine which pathogens and potentially foodborne toxins are currently considered to be of most concern;

• an expert elicitation to estimate the proportion of several key pathogens that are transmitted by contaminated food;

• NNDSS, state surveillance and the OzFoodNet outbreak register;

• hospitalisation separations from each state and territory in Australia; and

• mortality statistics for all of Australia from the Australian Bureau of Statistics (ABS). Although there are many challenges in estimating foodborne illness, the estimates are valuable for development of public health policy. These estimates provide big-picture information on the safety of food in Australia and help to evaluate national intervention and control strategies. In addition, the updated foodborne illness estimates provide a rational basis for undertaking additional costing studies. This report provides an updated picture on the incidence of foodborne illness in Australia circa 2010.

AimsThe aims of this study were to:

1. estimate the incidence, hospitalisations and deaths due to domestically acquired foodborne illness in Australia circa 2010, and

2. examine whether there have been changes to the incidence of foodborne illness over time.

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11Foodborne illness in Australia circa 2010

Comparing foodborne illness internationallyEstimation of the incidence of foodborne illness has proven important for public health policy, both in Australia and internationally.3,8,9 Studies to estimate incidence require complex methods due to the need to synthesize information from various sources, on many different pathogens and agents, and the need to consider many outcomes of illness. The literature was examined to review national studies in other countries that estimated the incidence of foodborne illness due to different pathogens. This included the previous Australian study estimating foodborne illness incidence circa 2000.10 The report reviews methods used to estimate the incidence of foodborne illnesses from nine key papers, which were the:

• USA assessment of 28 different pathogens or agents in 19995

• USA assessment of 30 different pathogens or agents in 20116,7

• France assessment of 24 pathogens or agents published in 200511

• Australia circa 2000 assessment of 25 pathogens, agents or sequelae, published in 20053,10

• the United Kingdom (UK) assessment of 24 pathogens or agents, published in 200212

• Greece assessment of 15 pathogens or agents, published in 201113

• Netherlands assessment of 18 pathogens, agents or sequelae, published in 201214

• New Zealand assessment of 10 pathogens or agents, published in 200015

• Jordan assessment of four pathogens or agents, published in 2009.16

Recent national burden of foodborne illness estimates are shown in Table 1 for Greece,13 UK,12

France,11 Australia,3 New Zealand,15 USA,6,7 Canada,17 and the Netherlands.14 However, it is not valid to directly compare these figures as the definition of ‘foodborne illness’ varies considerably across studies. Excluding the Australian figures, the incidence rates per million inhabitants per year ranged widely across countries from 4,500 cases in France to 369,305 cases in Greece. Hospitalisation rates per million inhabitants per year ranged from 173 in France to 905 in Greece, and deaths per million inhabitants per year ranged from three in Greece to 12 in France. When the incidence rates are compared across all countries, Greece has the highest incidence, followed by Australia, USA, New Zealand, the Netherlands, UK, and lastly France. In these studies, a similar pattern was seen for the rate of hospitalisations across countries, and deaths ranged from two to 12 foodborne deaths per million inhabitants (Table 1).

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Page 12: Foodborne illness in Australia - Department of Health · Foodborne illness in Australia circa 2010 7 Executive summary Foodborne illness causes significant morbidity and occasional

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Page 13: Foodborne illness in Australia - Department of Health · Foodborne illness in Australia circa 2010 7 Executive summary Foodborne illness causes significant morbidity and occasional

13Foodborne illness in Australia circa 2010

While these studies have commonalities in the overarching approach to estimating the burden of foodborne illness, some countries assess ‘all types’ of foodborne illness, while others are more limited in scope. For example, France and New Zealand did not include unknown pathogens. Not taking unknown pathogens into account results in an underestimate of the total burden on society. Similarly, not all studies included sequelae or non-gastrointestinal illnesses in their estimates. In addition, there are significant variations in the study designs used, the sampling methodologies and case definitions. The authors of these studies relied on surveillance data, hospital statistics, survey data, previously published studies, population based cohort studies, expert elicitation studies, reports of outbreak investigations, and community incidence data from cross-sectional surveys. It is important to recognise that differences in the sources of data and methods used impacts on results making it difficult to interpret comparisons between countries and across time.

A landmark paper regarding national foodborne illness estimation is the study from the USA by Mead et al.5 This paper has been cited an extraordinary number of times and the methodology replicated by other countries. The method used by Mead and colleagues to estimate the burden of infectious illnesses transmitted by food was to estimate the total burden of illnesses due to infections that could potentially be transmitted by food, and then the proportion of these thought to be foodborne. The burden of illness in the Mead study included total incidence, hospitalisations and deaths.5

The Mead methodology5 involves:

a) estimating the burden of all gastroenteritis potentially due to foodborne infection;

b) estimating the burden of gastroenteritis due to specific pathogens potentially transmitted by food;

c) estimating the burden of gastroenteritis due to unknown pathogens potentially transmitted by food;

d) estimating the burden of non-gastroenteritis illnesses due to specific pathogens potentially transmitted by food;

e) estimating the proportion of illness burden that is due to transmission of pathogens by food; and

f) accounting for uncertainty.

Since 1999, there have been some significant modifications and improvements in each of the steps used by Mead et al.5 More recently, disability adjusted life years (DALYS), general practitioner (GP) visits, medication, and costings have also been used to estimate the burden of total gastroenteritis, as well as foodborne illness incidence, hospitalisations and deaths. Also, new studies have been published, providing more information on incidence of certain pathogens. Cohort and cross-sectional studies are being used to inform estimates of the level of underreporting of illness to surveillance systems and large cohort studies estimating the incidence of total gastroenteritis have become invaluable to this work. In order to estimate the proportion of illness that is due to contaminated food, recent studies have used more formal studies of ‘expert opinion’ that have become increasingly rigorous in approach over time, and outbreak studies have become more available. Simulation techniques are now used to model uncertainty with varying levels of sophistication.

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In the last estimation of the incidence of foodborne illness in Australia, circa 2000,3,10,18 the rate of foodborne acute gastroenteritis was 281,250 (95% CrI: 208,333–359,375) per million inhabitants per year. The number of illnesses resulting from non-gastroenteritis foodborne illnesses (invasive listeriosis, toxoplasmosis and hepatitis A), and from their sequelae (HUS, IBS, GBS and ReA) was estimated to be 2,449 cases per million population annually.4

More recently, the second study of infectious intestinal disease in the community (IID2 study) estimated that around 25% of people in the UK suffer from an episode of Infectious Intestinal Disease (IID) each year and that norovirus, sapovirus, rotavirus and Campylobacter spp. were the most commonly identified pathogens.1 The IID2 study will form an important basis for future estimates of foodborne illness burden in England and Wales.

Scallan et al.6,7 recently updated estimates of foodborne illness incidence for the USA. The authors estimated the number of foodborne illnesses, hospitalisations and deaths caused by 31 domestically acquired pathogens, using surveillance data for the years 2000–2008, and used data from surveys, hospital records and death certificates to estimate domestically acquired foodborne illnesses, hospitalisations and deaths caused by unspecified agents. There were an estimated 31,438 (90% CrI: 22,074–42,475) cases of acute gastroenteritis and acute non-gastroenteritis caused by known pathogens, 187 (90% CrI: 132–253) hospitalisations and five deaths (90% CrI: 2–8), per million inhabitants.6 Eighty per cent of foodborne illness was due to unspecified agents,7 which was similar to the 73% estimated by Hall et al.3 for Australia circa 2000. In the USA, norovirus was found to account for the most illnesses (58%) and other important pathogens were non-typhoidal Salmonella spp. (11%), Clostridium perfringens (10%) and Campylobacter spp. (9%) circa 2000. Pathogens resulting in the most hospitalisations were non-typhoidal Salmonella spp. (35%), norovirus (26%), Campylobacter spp. (15%) and Toxoplasma gondii (8%). Non-typhoidal Salmonella spp. were also responsible for the most deaths (28%), closely followed by T. gondii (24%), Listeria monocytogenes (19%) and norovirus (11%). The incidence rate for unspecified agents was estimated at 128,404 (90% CrI: 66,318–204,670) cases, 240 (90% CrI: 33–526) hospitalisations, and six (90% CrI: 1–11) deaths per million per year in the USA.

The main types of outcome measures of disease burden used in the estimation of foodborne illnesses internationally have been:

• Incidence of new illnesses, hospitalisations, and deaths in a certain time period and population. For some longer lasting illnesses, prevalence may be relevant.

• DALYs.

• General practitioner (GP) visits, medication use, days of lost productivity.

• The direct and indirect costs due to a disease in a set time period. Most of the outcomes above are required to conduct an economic assessment and are combined with raw costing information.

Incidence, hospitalisations, sequelae and deaths are all useful outcome measures and some studies have shown that DALYs also give another useful perspective. However DALYs do not take into account differences in socioeconomic and cultural circumstances between individuals and require subjective value judgements on how to weight or discount for age of onset, disability weights, and future losses.19 Questions remain about the ability of different countries, including Australia, to provide high quality, detailed data and to compare disability weights across countries. See Technical Appendix 1, page 37 for further comparisons.

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15Foodborne illness in Australia circa 2010

MethodsThis report provides estimates of community incidence, hospitalisations, and deaths for 23 pathogens and four sequelae following illness with these pathogens for Australia circa 2010. These pathogens (listed in Table 2) were chosen after review of key papers, and through consultations with OzFoodNet staff, communicable disease experts, microbiologists and food safety specialists around Australia. Pathogens that are considered rare in Australia, or are mostly acquired overseas were excluded.

The fundamental approach to this study builds on methods that were used in Australia circa 2000, and that have also been used in international estimation efforts in the USA and the Netherlands.3,6,14

This approach uses estimates of incidence, hospitalisations or deaths to generate estimates of the yearly incidence of foodborne illness that are domestically acquired and allows for variability in yearly estimates as well as other sources of uncertainty as described below.

Pathogens includedIn February 2012, foodborne disease epidemiologists and food safety specialists were consulted about what pathogens to include in an estimation of foodborne illness in Australia circa 2010. There was consensus amongst experts to include similar pathogens to the previous estimate circa 2000. Experts recommended that the ‘Assessment of foodborne illness, Australia circa 2010’ include 19 pathogens, two chemical agents and four sequelae of foodborne illness (Table 2). In addition to these recommended pathogens, three viruses (adenovirus, astrovirus and sapovirus) were included as they had been associated with a reasonable proportion of all gastroenteritis episodes in recent international studies.1 Finally, a category of gastroenteritis due to unspecified agents was included.

Table 2: Pathogens, agents and conditions recommended by experts for inclusion in Australian estimation of foodborne illness circa 2010*

Viruses Bacteria Protozoa Chemicals Sequelae

Rotavirus Bacillus cereus Toxoplasma gondii

Scombrotoxicosis Guillain-Barré syndromeNorovirus Shigella Ciguatera

Hepatitis A Staphylococcus aureus Cryptosporidium spp.

Vibro parahaemolyticus Irritable bowel syndromeShiga toxin-producing E. coli Giardia lamblia

Other pathogenic E. coli

Campylobacter spp. Reactive arthritis

Clostridium perfringens

Listeria monocytogenes Haemolytic uraemic syndromeSalmonella, non-typhoidal

Salmonella Typhi

Yersinia enterocolitica

Me

tho

ds

*In addition to these recommended pathogens, the circa 2010 study included three viruses (adenovirus,

astrovirus and sapovirus) and a category of gastroenteritis due to unspecified agents.

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16

Data sourcesThe main sources of data used in this study are listed in Box 1. Estimates of incidence relied on notifiable surveillance data at the national and state level, other surveillance data available through the OzFoodNet outbreak register, cross-sectional data from the National Gastroenteritis Survey II (NGSII) and cohort study data from the water quality study (WQS).2,20 Estimates of severe illness were made using hospitalisation and mortality data.

Further details of the use of data sets for this study are provided in Technical Appendices 3 and 7 (pages 52 and 64).

Box 1: Australian datasets used to assess foodborne illness, hospitalisations and deaths circa 2010

State and territory surveillance: In all Australian jurisdictions, doctors and pathology laboratories are required by legislation to report patients with diagnoses of certain infections to a state or territory health department. Basic information is then stored on each case-patient. The specific illnesses that are reportable vary slightly between each jurisdiction; however data elements and case definitions for many illnesses are largely standardised across Australia. The numbers of infections or foodborne syndromes where illnesses were not nationally notifiable were used from state or territory surveillance, as well as the proportion of infections acquired from overseas travel from infections where illnesses were not nationally notifiable.

National Notifiable Diseases Surveillance System (NNDSS): NNDSS was established in 1990 and is managed by the Australian Government Department of Health through the Communicable Diseases Network Australia. State and territory health departments collect notifications of communicable disease under their respective public health legislation. Under the National Health Security Agreement, states and territories forward de-identified notification data on the nationally agreed set of 65 communicable disease to the Australian Government Department of Health for the purposes of national communicable disease surveillance, although not all 65 diseases are notifiable in each jurisdiction. The national numbers of infections or syndromes from NNDSS from 2006–2010, which are nationally notifiable and potentially due to food, were used to assess the incidence of foodborne illness.

OzFoodNet outbreak register: In 2000, the Australian Government established OzFoodNet— a national network of epidemiologists in state and territory health departments to enhance national surveillance of foodborne illness. OzFoodNet epidemiologists collect enhanced surveillance data on a variety of foodborne illnesses. The OzFoodNet outbreak register aggregates data on outbreaks of disease into a national dataset. A cleaned version of the outbreak register for the years 2006 to 2009 was used for those pathogens that occur in outbreaks, especially those that are not nationally notified.

National Gastroenteritis Surveys I & II (NGSI & NGSII): OzFoodNet and the National Centre for Epidemiology and Population Health (NCEPH), funded by the Australian Government Department of Health and New South Wales Food Authority, conducted national cross-sectional surveys to estimate the national incidence of gastroenteritis meeting a specific case definition. The surveys used computer assisted telephone interviews. NGSI was conducted in 2001–2, while NGSII was conducted in 2008–9.

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17Foodborne illness in Australia circa 2010

Water Quality Study (WQS): The WQS was conducted by the Cooperative Research Centre for Water Quality and Treatment between 1997 and 1999 in the suburbs of Melbourne. This randomised-controlled trial included 600 families and examined the relationship between water quality and gastroenteritis. For further information on the WQS refer to http://www.med.monash.edu.au/epidemiology/infdis/waterqstudy.html. After applying an age adjustment, the Water Quality Study was used to determine the proportion of infectious agents causing diarrhoea in community gastroenteritis.

Hospitalisation data: Principal and additional hospital diagnoses for the pathogens of interest were obtained for all states and territories. Data from Tasmania, Australian Capital Territory, Western Australia, South Australia, and Northern Territory was for 2006–2010, data from New South Wales was for 2009 and 2010, and data from Victoria was for the 2009–2010 financial year.

Australian Bureau of Statistics mortality data: The ABS supplied aggregated data on deaths registered in Australia from 2001 to 2010, by age group and sex, where the underlying or multiple cause of death was from an illness that could potentially be foodborne.

Other: The assessment of foodborne illness also relied on data from expert elicitations as well as published reports in the literature. The expert elicitations took place in 2005 and 2009 and included eleven participants comprising of two public health physicians, two microbiologists, one food safety officer, two public health veterinarians, three foodborne disease epidemiologists and one research scientist.

IncidenceTotal incidence of gastroenteritis

To estimate the annual incidence of gastroenteritis in Australia, OzFoodNet, in conjunction with the National Centre for Epidemiology and Population Health (NCEPH), and funded by the Australian Government Department of Health and New South Wales Food Authority, conducted the NGSII over a 12-month period between February 2008 and January 2009. This was a cross sectional study using a nationally-representative telephone survey to improve the estimates of the incidence of gastroenteritis and assess whether there were significant changes in incidence from the previous National Gastroenteritis Survey (NGSI) conducted in 2001–2. Gastroenteritis was defined as experiencing ≥3 loose stools and/or ≥2 vomits in a 24 hour period, or if the person had concomitant respiratory symptoms, gastroenteritis was defined as ≥4 loose stools and/or ≥3 vomits in a 24 hour period. NGSII provided an incidence estimate of 0.74 (95%CI 0.64–0.84) episodes of gastroenteritis per person per year, or 15.9 million cases each year in Australia (Technical Appendix 2, page 45).

Incidence by pathogen

Three main approaches were used to calculate the incidence of illness due to each pathogen or agent:

1. Notifiable surveillance approach using data from NNDSS or state-based notification systems;

2. Pathogen fraction approach using data from the NGSII together with cohort studies such as the WQS2,20 conducted in Melbourne between 1997 and 1999;

3. Other surveillance approach using data from the OzFoodNet outbreak register, or from hospitalisations.

Box 1: Australian datasets used to assess foodborne illness, hospitalisations and deaths circa 2010 (continued)

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18

Approaches 1 and 3 both consist of scaling up from surveillance data to estimates in the community by use of underreporting and outbreak multipliers. Approach 2 can be thought of as a top-down approach; it attributes a fraction of all gastrointestinal illness to the given pathogen.

These three approaches were considered to form a hierarchy, with the notifiable surveillance approach used by preference, followed by the pathogen fraction approach, and the other surveillance approach where other data sources were not available. Where possible, more than one approach was used for each pathogen to provide a secondary estimate used as a tool to validate the methods.

In the final calculations, the notifiable surveillance approach was used for 11 pathogens, the pathogen fraction approach for 6, and the other surveillance approach for five pathogens or agents (Technical Appendix 4, page 54, and Technical Appendix 11, page 80). An additional approach (Technical Appendix 6, page 63) based on USA seroprevalence data was applied to toxoplasmosis,21 owing to a lack of Australian data.

Multipliers and uncertainty

Within each approach, multipliers were applied to adjust for factors such as the age profile of cohort studies, and the proportion of the population covered by surveillance. The study by Hall et al.22 was used as a basis for estimating underreporting multipliers for moderate illnesses and bloody diarrhoea, and the underreporting factor for serious illnesses was estimated as one reported illness for every two illnesses that occur in the community, as in Mead et al.5 In addition, an outbreak multiplier was applied to further adjust for estimates made using other surveillance data. More details of the underreporting multipliers are provided in Technical Appendix 5 (page 56).

Two other key multipliers were the ‘domestically acquired multiplier’ and the ‘foodborne multiplier’. The domestically acquired multiplier adjusted total incidence data to exclude infections acquired overseas. For many pathogens, this multiplier was estimated using NNDSS data by state and territory. Other pathogens with short duration of illness were assumed to be 100% domestically acquired.

Foodborne multipliers were estimated for nine pathogens using expert elicitation data using a Delphi approach from 2009 and for a further nine pathogens using a Delphi approach from 2005. All illness due to the seafood toxins was assumed to be caused by food. More details on the estimation of the proportion of illness that is foodborne are given in Technical Appendix 5 (page 56).

Uncertainty in estimates of incidence and in the value of key multipliers was included by means of distributions. The main distributions used were empirical distributions and program evaluation reveiw technique (PERT) distributions. Empirical distributions were used for counts of cases detected by year through notifiable or other surveillance systems. PERT distributions are based on the beta distribution, and are commonly used for expert elicitation and risk assessment studies. This distribution was used widely in the analysis as it allows for asymmetric distributions, and can be easily produced from many data sources including expert elicitation data.

Incidence of sequelae

This report estimates the incidence of sequelae illnesses for GBS, HUS, IBS and ReA using data from Australian and international literature, as well as from NNDSS. Where available, data from large cohort studies, Australian surveillance studies, and meta-analyses were used in conjunction with adjusted notification data from preceding foodborne gastrointestinal infections. More details on the literature and methods used to estimate the number of cases of foodborne illness sequelae can be found in Technical Appendix 8 (page 70).

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19Foodborne illness in Australia circa 2010

Hospitalisations and deaths from foodborne illness

Yearly hospitalisations were estimated from state and territory hospitalisation data (ICD-10-AM codes) and deaths from the ABS mortality data (ICD-10 codes) for the 24 potentially foodborne illnesses in Table 2, as well as unknown gastroenteritis, listed as either principal or additional diagnosis. Hospitalisation data were provided over the period 2006 to 2010 for most states and territories, and this was used to calculate national estimates for 2006–2010. A large number of hospitalisations and deaths due to gastrointestinal illness do not identify a causal pathogen, and these were categorised as ‘gastroenteritis of unknown aetiology’ (see Technical Appendix 7, page 64 for ICD-10-AM codes used).

Monte Carlo simulations were used to adjust for travel associated cases, and to estimate the proportion of hospitalisations and deaths that were foodborne. Similar multipliers were used to adjust raw hospitalisation and mortality data as for incidence data, as described in Technical Appendix 7 (page 64). More details on methods to estimate sequelae hospitalisations and deaths can be found in Technical Appendix 9 (page 74).

Changes in methods to calculate incidence from 2000There were several changes in the methods used to calculate incidence and hospitalisations since the estimates circa 2000, including updated underreporting multipliers22 and a more rigorous expert elicitation.23 These changes make direct comparison of the circa 2010 findings with those of the circa 2000 estimates potentially misleading (Box 2). To estimate changes over time, circa 2000 estimates were recalculated with original data but using identical methods to those used to calculate the circa 2010 estimates. The circa 2000 incidence rate for foodborne gastroenteritis and key pathogens was then calculated using population statistics from the ABS from 1996 to 2000.24 Only pathogens for which there were surveillance data from both time periods were included in this analysis. More details on the new methods to calculate incidence from 2000 can be found in Technical Appendix 10 (page 79).

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20

Box 2: Changes in methods to estimate foodborne illness in Australia since circa 2000

Domestically acquired multiplier: In 2000, this was estimated using Victorian data only. In 2010, data from all jurisdictions were obtained to inform the estimate of the proportion of cases that were acquired in Australia. Pathogen-specific changes are provided in Table T5.1 of Technical Appendix 5 (page 56).

Underreporting multiplier: A study published by Hall et al. (2008) produced more accurate, data-driven estimates of the underreporting multipliers for Salmonella, Campylobacter, and STEC. These changes have a considerable impact on the circa 2010 estimates – for instance the multiplier for Salmonella decreased from 15 to seven following the use of this study.

Foodborne multiplier: An additional expert elicitation process allowed us to update this multiplier to include assessments of uncertainty from experts. Table T5.2 of Technical Appendix 5 (page 56) provides all of the foodborne multipliers by pathogen and there data source. Changes in the foodborne multipliers have a considerable effect on the overall proportion of gastroenteritis that is attributed to food.

Outbreak multiplier: Given that illnesses with short duration are less likely to be confirmed, the outbreak multiplier was estimated based on the total number of ill patients in confirmed outbreaks, using Salmonella as the reference pathogen. This multiplier was estimated using NNDSS data and the OzFoodNet outbreak register, which are more nationally representative than the Victorian state outbreak and surveillance data used in 2000.

Choice of approach: As in 2000, there were three main approaches to estimate incidence of pathogens using notifiable surveillance data, cohort data, and outbreak data. However, this time two methods for each pathogen were used to test the sensitivity of the results to the choice of method, and to help identify the most appropriate method. Although only the results of the primary method are reported, the secondary approach is listed in the pathogen sheets in Technical Appendix 11 (page 80). In some cases, such as Cryptosporidium spp., the choice of primary method changed from 2000 to 2010.

Water Quality Study: In 2000, the rates from the WQS were used but in 2010 rates were adjusted to account for the sample selection of families with children. This is an improvement as the age structure of the sample for the WQS does not accurately reflect the age structure of the Australian population. As gastroenteritis is age related, adjustment gives a better estimate for the whole population. For rotavirus, WQS data were adjusted for changes over time, based on published information.

Hospitalisation data: In this assessment the numbers of hospitalisations for both principal and additional diagnoses was acquired, rather than only principal diagnosis as in 2000. The 2000 estimate included a multiplier to estimate total hospitalisations while circa 2010 data included all hospitalisations. A multiplier was applied in both 2000 and 2010 to account for underreporting.

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21Foodborne illness in Australia circa 2010

ResultsIncidence of gastroenteritis due to foodBased on data collected from 2006–2010, each year, an estimated 4.1 million (90% CrI: 2.3–6.4 million) cases of foodborne gastroenteritis occur in Australia, equating to 0.19 cases per person per year. Foodborne gastroenteritis was considered to include any infectious gastroenteritis caused by eating food, including food contaminated just before eating.3 An estimated 25% (90% CrI: 13–42%) of 18 known gastrointestinal pathogens were transmitted by contaminated food (Table 3). Bacterial pathogens had the highest foodborne proportion with 36% estimated to be transmitted by contaminated food, compared to 16% for viruses, and 11% for parasites.

Of the total 4.1 million cases of foodborne gastroenteritis annually, about 0.8 million (20%) were estimated to be due to one of the 18 known pathogens. The remaining 3.3 million cases (80%) were due to unknown or unidentified pathogens. The key known pathogens in terms of incidence were: pathogenic E. coli, norovirus, Campylobacter spp., and non-typhoidal Salmonella spp. Together these four pathogens make up 93% of foodborne episodes due to the 18 known pathogens.

Incidence of other foodborne illnessIn addition to foodborne gastroenteritis, circa 2010, contaminated food was estimated to cause around 5,100 cases of non-gastrointestinal illness each year in Australia (Table 4). T. gondii was the most common cause of non-gastrointestinal illness due to food. The percentage of these illnesses that were estimated to be transmitted by contaminated food ranged from 12% for hepatitis A up to 100% for the fish-associated diseases scombrotoxicosis and ciguatera.

Incidence of sequelae following foodborne gastroenteritisCirca 2010, contaminated food was estimated to cause around 35,840 episodes of sequelae following acute gastroenteritis each year in Australia (Table 5). This represents a rate of 1,620 sequel illnesses per million population resulting from foodborne illness. IBS was the most common sequelae, causing an estimated 19,500 episodes each year; followed by ReA resulting in 16,200 episodes each year.

Re

sults

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22

.

Tab

le 3

: Est

ima

ted

ann

ual n

umb

er

of e

pis

od

es

of d

om

est

ica

lly a

cq

uire

d fo

od

bo

rne

ga

stro

ent

eri

tis c

aus

ed

by

pa

tho

ge

ns in

Aus

tra

lia, c

irca

201

0

Path

og

en

Me

dia

n n

um

be

r of d

om

est

ica

lly

ac

qu

ired

ep

iso

de

s o

f ga

stro

en

terit

is

(90%

CrI)

Me

dia

n p

erc

en

tag

e

foo

db

orn

e(9

0% C

rI)

Me

dia

n n

um

be

r of d

om

est

ica

lly a

cq

uire

d e

pis

od

es

of

ga

stro

en

terit

is (

90%

CrI)

Ba

cte

ria

Baci

llus

cere

us

3,35

0 (9

00–1

0,10

0)10

0% (

98–1

00)

3,35

0 (9

00–1

0,10

0)

Ca

mp

ylo

ba

cter

sp

p.

234,

000

(147

,000

–374

,000

)77

% (

62–8

9)17

9,00

0 (1

08,5

00–2

90,0

00)

Clo

strid

ium

per

frin

gen

s16

,500

(2,

600–

53,4

00)

98%

(86

–100

)16

,100

(2,

550–

50,6

00)

STEC

4,30

0 (2

,050

–9,5

00)

56%

(32

–83)

2,35

0 (9

50–5

,850

)

Oth

er p

ath

og

en

ic E

. co

li1,

100,

000

(833

,000

–1,4

50,0

00)

23%

(8–

55)

255,

000

(85,

800–

632,

000)

Salm

on

ella

, no

n-ty

ph

oid

al

56,2

00 (

31,9

00–1

01,0

00)

72%

(53

–86)

39,6

00 (

21,2

00–7

3,40

0)

Salm

on

ella

Typ

hi

20 (

8–45

)75

% (

2–97

)15

(5–

30)

Shig

ella

3,00

0 (1

,650

–5,4

00)

12%

(5–

23)

350

(150

–850

)

Sta

phy

loco

ccu

s a

ure

us

1,30

0 (2

00–7

,050

)10

0% (

95–1

00)

1,30

0 (2

00–7

,000

)

Vib

rio p

ara

ha

emo

lytic

us

60 (

15–1

70)

75%

(5–

96)

40 (

10–1

20)

Yers

inia

en

tero

colit

ica

1,50

0 (9

00–2

,500

)84

% (

28–9

4)1,

150

(650

–1,9

50)

Vir

use

s

Ad

en

ovi

rus

88,4

00 (

28,8

00–2

05,0

00)

2% (

1–3)

1,65

0 (5

00–4

,650

)

Ast

rovi

rus

67,1

00 (

20,9

00–1

55,0

00)

2% (

1–3)

1,30

0 (3

50–3

,400

)

No

rovi

rus

1,55

0,00

0 (1

,220

,000

–1,9

40,0

00)

18%

(5–

35)

276,

000

(78,

100–

563,

000)

Rota

viru

s44

,800

(18

,500

–90,

800)

2% (

1–3)

850

(300

–2,0

00)

Sap

ovi

rus

81,6

00 (

63,4

00–1

02,0

00)

18%

(5–

35)

15,0

00 (

7,45

0–24

,300

)

Para

site

s

Cry

pto

spo

ridiu

m s

pp

.17

,900

(8,

150–

39,8

00)

10%

(1–

27)

1,70

0 (1

50–6

,100

)

Gia

rdia

lam

blia

32,8

00 (

19,8

00–5

6,40

0)6%

(1–

50)

3,70

0 (8

00–1

0,60

0)

Sub

tota

l3,

090,

000

(2,8

10,0

00–3

,900

,000

)25

% (

13–4

2)79

8,00

0 (5

28,0

00–1

,310

,000

)

Un

kno

wn

ae

tiolo

gy

12,8

00,0

00 (

10,5

00,0

00–1

4,50

0,00

0)25

% (

13–4

2)3,

310,

000

(1,8

00,0

00–5

,152

,000

)

Tota

l15

,900

,000

(13

,700

,000

–18,

000,

000)

25%

(13

–42)

4,11

0,00

0 (2

,330

,000

–6,3

90,0

00)

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23Foodborne illness in Australia circa 2010

Table 4: Estimated annual number of episodes of acute foodborne illness due to pathogens or syndromes that do not result in gastroenteritis in a typical year in Australia, circa 2010

Pathogen/Acute illnessMedian percentage foodborne (90% CrI)

Median number of domestically acquired foodborne illnesses

(90% CrI)

Hepatitis A 12% (5–24) 40 (10–100)

Listeria monocytogenes 98% (90–100) 150 (50–200)

Toxoplasma gondii 31% (4–74) 3,750 (1,400–7,150)

Ciguatera 100% (100–100) 150 (40–300)

Scombrotoxicosis 100% (100–100) 1,050 (0–2,450)

Total 40% (25–59) 5,140 (3,530–7,980)

Table 5: Estimated annual incidence of sequelae following foodborne gastroenteritis in a typical year in Australia, circa 2010

Sequelae Foodborne agents

Median percentage foodborne(90% CrI)

Median number of domestically acquired foodborne illnesses

(90% CrI)

Guillain-Barré syndrome

Campylobacter spp. 25% (10–43) 70 (30–150)

Haemolytic uraemic syndrome

Shiga toxin-producing E. coli

33% (17–53) 70 (25–200)

Irritable bowel syndrome

Campylobacter spp. , non-typhoidalSalmonella spp., Shigella

13% (8–20) 19,500 (12,500–30,700)

Reactive arthritis

Campylobacter spp. , non-typhoidalSalmonella spp., Shigella, Yersinia enterocolitica

48% (36–62) 16,200 (8,750–30,400)

Total 35,840 (25,000–54,000)

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24

Changes in incidence from 2000A direct comparison of incidence estimates with those circa 2000 is complicated by changes in methods between the two studies. Points of difference and method-related issues are described in Box 2 in the Methods section.

Foodborne gastroenteritis

The proportion of gastroenteritis that was estimated to be foodborne circa 2010 was 25%, compared to 32% in 2000. These changes are largely driven by changes in the estimates of the foodborne multiplier for other (non-STEC) pathogenic Escherichia coli and norovirus, as ‘other pathogenic E. coli’ is assumed to be 23% foodborne compared to 50% foodborne in 2000 and norovirus is assumed to be 18% foodborne compared to 25% foodborne in 2000. These lower proportions represent better informed estimates by experts rather than true changes in the proportion of disease transmitted by food. By applying the 2010 estimate of 25% foodborne to the results of the NGSI study that was conducted in 2001, there are an estimated 4.3 million (90% CrI: 2.2–7.3 million) episodes of foodborne gastroenteritis circa 2000. When adjusted for changes in population size over this period, this represents a 17% decrease in the rate of foodborne gastroenteritis between 2000 and 2010 (rate ratio 0.83, 90% CrI: 0.4–1.8), although credible intervals overlap (Table 6).

Salmonella and Campylobacter

Comparing estimates of non-typhoidal Salmonella spp. and Campylobacter spp. with those circa 2000 requires further adjustment for considerable changes in methods, such as the halving of the underreporting multiplier for non-typhoidal Salmonella spp. Recalculation of the 2000 estimates using these new methods gives a revised estimate of 28,000 (90% CrI: 15,000–50,000) yearly cases of foodborne gastroenteritis due to non-typhoidal Salmonella spp. and 139,000 (90% CrI: 82,500–227,000) yearly cases of foodborne gastroenteritis due to Campylobacter spp. That is, the 2010 point estimates represent around 11,000 more cases of foodborne non-typhoidal Salmonella spp. and 40,000 more cases of foodborne Campylobacter spp.; a rate increase of 24% for non-typhoidal Salmonella spp. and 13% for Campylobacter spp. when taking into account population changes (Table 6). Credible intervals for all incidence rate ratios include uncertainty derived from incidence multipliers, and were considerably wider than intervals for ratios derived from raw surveillance data.

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25Foodborne illness in Australia circa 2010

.

Tab

le 6

: Co

mp

ari

son

of a

nnua

l inc

ide

nce

est

ima

tes

and

ra

tes

fro

m r

evis

ed

circ

a 2

000

and

circ

a 2

010

of f

oo

db

orn

e g

ast

roe

nte

ritis

, key

p

ath

og

ens

, and

tw

o s

eq

uela

e u

sing

cur

rent

ass

ump

tions

, Aus

tra

lia

Path

og

en

/Illn

ess

2000

2010

Rate

ratio

(90%

CrI)

Inc

ide

nc

e(9

0% C

rI)

Rate

pe

r mill

ion

p

op

ula

tion

(90%

CrI)

Inc

ide

nc

e(9

0% C

rI)

Rate

pe

r mill

ion

p

op

ula

tion

(90%

CrI)

Foo

db

orn

e

ga

stro

en

terit

is4.

3 m

illio

n(2

.2–7

.3 m

illio

n)

224,

000

(116

,000

–374

,000

)4.

1 m

illio

n(2

.3–6

.4 m

illio

n)

186,

000

(105

,000

–289

,000

)0.

83(0

.4–1

.8)

Ca

mp

ylo

ba

cte

r sp

p.

139,

000

(82,

500–

227,

000)

7,40

0(4

500–

12,2

00)

179,

000

(108

,500

–290

,000

)8,

400

(5,0

50–1

3,65

0)1.

13(0

.5–2

.3)

Salm

on

ella

sp

p.,

n

on

-typ

ho

ida

l28

,000

(15,

000–

50,0

00)

1,50

0(8

00–2

,700

)39

,600

(21,

200–

73,4

00)

1,85

0(1

,000

–3,3

50)

1.24

(0.5

–2.8

)

Salm

on

ella

Typ

hi

9 (3

–21)

0.5

(0–1

)15

(5

–30)

0.6

(0–1

)1.

2 (0

.5–2

.6)

Shig

ella

515

(175

–1,3

00)

28

(9–7

0)35

0 (1

50–8

50)

16

(6–4

0)0.

57

(0.1

5–2.

25)

He

pa

titis

A24

5 (6

5–72

5)13

(3

–40)

40

(10–

100)

2 (1

–5)

0.15

(0

.06–

0.4)

List

eria

m

on

ocy

tog

enes

125

(70–

185)

7 (4

–10)

150

(50–

200)

7 (3

–10)

1 (0

.4–1

.9)

Gia

rdia

lam

blia

2,60

0 (5

65–7

,400

)14

0 (3

0–40

5)3,

700

(800

–10,

600)

175

(35–

490)

1.25

(0

.2–7

.5)

Gu

illa

in-B

arré

sy

nd

rom

e50

(2

5–10

0)2.

8 (1

–6)

70

(30–

150)

3.1

(2–6

)1.

13

(0.5

–3.6

)

Irrita

ble

bo

we

l sy

nd

rom

e14

,800

(9

,500

–23,

500)

850

(550

–135

0)19

,500

(1

2,50

0–30

,700

)91

5 (5

70–1

,440

)1.

07

(0.5

–2)

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26

Other pathogens

Comparing estimates of other key pathogens shows that the number of hepatitis A and Shigella cases has decreased since 2000, with rate decreases of 85% and 43% respectively (Table 6). The rate of L. monocytogenes has remained the same, and the rates of Salmonella Typhi and Giardia lamblia increased 20% and 25% respectively (Table 6). Comparing estimates of two sequelae shows an increase in the rate of both GBS and IBS from 2000 to 2010 (Table 6). While estimates of Staphylococcus aureus circa 2010 are lower than those estimated circa 2000, this may be a consequence of changes in methods for outbreak data, or the considerable variation in yearly cases associated with outbreaks. The estimates for S. aureus and Cryptosporidium for circa 2000 could not be recalculated using new methods as source data has changed, and the new source of data was not available circa 2000. No new sources of data were available for ‘other pathogenic E. coli’, and the other viral pathogens, so that meaningful comparison of the two time periods is not possible.

Severe foodborne illness

Hospitalisations

Each year, there were an estimated 30,600 hospitalisations with foodborne gastrointestinal illness as the principal or additional diagnosis (Table 7). Of these, 5,900 were due to known pathogens each year, with Campylobacter spp. (3,200 hospitalisations) and non-typhoidal Salmonella spp. (2,100 hospitalisations) the main causes. The remaining 24,700 hospitalisations were due to foodborne gastroenteritis of unknown aetiology.

Further to this, there were an estimated 240 hospitalisations for acute foodborne illness that were not gastrointestinal, with L. monocytogenes as a key cause. Sequelae resulting from gastrointestinal illness were estimated to cause 1,080 hospitalisations each year, as a secondary outcome from illness due to foodborne pathogens.

Deaths

There were an estimated 60 (90% CrI: 45–75) deaths each year due to foodborne gastroenteritis (Table 7). Of these, non-typhoidal Salmonella spp. was the most commonly identified pathogen, causing an estimated 15 foodborne deaths each year. Gastroenteritis of unknown aetiology was a principal or additional cause of death in an estimated 39 people per year.

Non-gastrointestinal foodborne illness caused an additional 16 deaths each year, with most of these attributed to L. monocytogenes. Finally, 10 deaths each year were due to sequelae following foodborne illness with pathogens such as STEC, non-typhoidal Salmonella spp., Campylobacter spp., Shigella, and Yersinia enterocolitica. The leading cause of death from foodborne sequelae was GBS following campylobacteriosis, which resulted in an estimated six deaths each year.

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27Foodborne illness in Australia circa 2010

Changes in severe illness from circa 2000There were relatively few methodological changes associated with estimates of hospitalisations and deaths due to foodborne pathogens allowing for direct comparison between 2000 and 2010 for many pathogens (see Hall et al3,10 for circa 2000 estimates).

Estimates of hospitalisations for both non-typhoidal Salmonella spp. and Campylobacter spp. increased from 2000 to 2010, with a rise in around 1,000 hospitalisations for each pathogen. In particular, the estimated hospitalisations for non-typhoidal Salmonella spp. approximately doubled in the ten year period from an estimated 1,060 hospitalisations circa 2000 to an estimated 2,100 hospitalisations in circa 2010.

As was noted for incidence, estimates of hospitalisations for Staphylococcus aureus, as well as for Vibrio parahaemolyticus, declined since 2000, although numbers for each are small and diagnosis in hospital settings is likely to be poor. The decline in hospitalisations for rotavirus was less marked than that for incidence, but does show a decrease from an estimated 70 foodborne hospitalisations per year in 2000 to 50 each year in 2010. The increase in estimated hospitalisations for foodborne norovirus from four per year in 2000 to 150 per year in 2010 reflects increased testing and diagnosis of this pathogen.

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28

Table 7: Estimated annual number of hospitalisations and deaths caused by domestically acquired foodborne pathogens in Australia, circa 2010

Pathogen/Illness ICD-10-AM codeMedian number of

hospitalisations (90% CrI)

Median number of deaths (90% CrI)

Gastrointestinal foodborne illness

Bacteria

Bacillus cereus A05.4 25 (4–45) 0 (0–0)

Campylobacter spp. A04.5 3,200 (2,100–4,500) 3 (2–4)

Clostridium perfringens A05.2 0 (0–2) 1 (0–1)

STEC A04.3 7 (2–15) 0 (0–0)

Other pathogenic E. coli A04.0, A04.1, A04.4 20 (6–50) 0 (0–1)

Salmonella, non-typhoidal A02.0–A02.9 2,100 (1,300–3,000) 15 (8–20)

Salmonella Typhi A01.0 15 (6–35) 0 (0–0)

Shigella A03 25 (9–50) 0 (0–0)

Staphylococcus aureus A05.0 10 (7–20) 0 (0–0)

Vibrio parahaemolyticus A05.3 1 (0–1) 0 (0–0)

Yersinia enterocolitica A04.6 35 (10–65) 1 (0–1)

Viruses

Adenovirus A08.2 15 (8–25) 0 (0–0)

Astrovirus n/a not applicable not applicable

Norovirus A08.1 150 (35–350) 1 (0–2)

Rotavirus A08.0 50 (30–100) 0 (0–0)

Sapovirus n/a not applicable not applicable

Parasites

Cryptosporidium spp. A07.2 40 (6–100) 0 (0–0)

Giardia lamblia A07.1 100 (25–300) 0 (0–0)

Subtotal5,900 (4,700–

7,500)21 (14–26)

Unknown aetiologyA08.4, A09, A09.0, A09.9

24,700 (22,600–27,800)

39 (27–54)

Total (foodborne gastroenteritis)

30,600 (28,000–34,000)

60 (45–75)

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29Foodborne illness in Australia circa 2010

Pathogen/Illness ICD-10-AM codeMedian number of

hospitalisations (90% CrI)

Median number of deaths (90% CrI)

Non-gastrointestinal foodborne illness

Hepatitis A B15.9 20 (6–50) 0 (0–2)

Listeria monocytogenes A32 150 (100–250) 15 (9–20)

Toxoplasma gondii B58 30 (10–60) 1 (0–2)

Ciguatera T61.0 25 (10–40) 0 (0–0)

Scombrotoxicosis T61.1 8 (5–10) 0 (0–0)

Total (non-gastrointestinal) 240 (180–350) 16 (10–21)

Sequelae resulting from foodborne illness

Guillain-Barré syndrome G61.0 70 (30–150) 6 (2–10)

Haemolytic uraemic syndrome

D59.3 70 (25–200) 2 (1–3)

Irritable bowel syndrome K58.0, K58.9 915 (550–1,400) 2 (1–2)

Reactive arthritisM02.1, M02.3, M02.8, M03.2

25 (20–40) 0 (0–0)

Total (sequelae) 1,080 (700–1,600) 10 (5–14)

Table 7: Estimated annual number of hospitalisations and deaths caused by domestically acquired foodborne pathogens in Australia, circa 2010 (continued)

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30

DiscussionThere are an estimated 4.1 million (90% CrI: 2.3–6.4 million) cases of gastroenteritis attributed to contaminated food in Australia each year. This equates to each Australian experiencing an episode of foodborne gastroenteritis approximately every five years. While foodborne gastroenteritis is often not serious, it results in considerable costs to society through medical costs and days of work lost. Approximately one in five people with gastroenteritis seek medical attention, which could mean that foodborne illness results in as many as a million visits to a doctor annually.18

Acute non-gastroenteritis illnesses and sequelae due to contaminated food are also a significant contributor to the incidence of foodborne illness in Australia. While there are notably fewer cases from these illnesses than from foodborne gastroenteritis, they cause more serious symptoms and are of longer duration. In this study, sequelae responsible for the highest rates of illness included IBS and ReA, which are not fatal, but cause disabling symptoms.25,26 It is important to recognise that the current study estimates yearly incident cases only, and does not measure the long-term burden of these sequelae.

It was concerning to identify that foodborne Campylobacter spp. were responsible for 80% of the sequelae cases estimated in this study, as well as approximately 179,000 cases of gastroenteritis every year. The rate of infection due to Campylobacter spp. has increased over the last 10 years and is higher than many other developed nations. For example, the Australian Campylobacter spp. rate is approximately 10 times higher than the USA,27 double that of the Netherlands,14 and slightly higher than that of the UK.1 In New Zealand, source attribution and policy regulation led to interventions that effectively lowered Campylobacter spp. rates and sequelae rates as well. Interventions introduced in 2006 in New Zealand, including Campylobacter spp. performance targets at primary processing and the promotion of freezing all fresh poultry meat, which by 2008 resulted in the rate of Campylobacter spp. notifications decreasing by 54% and a fall in GBS hospitalisations by 13%.28,29 If Australia were able to introduce successful interventions and experience the same decreases in infection as New Zealand, the rate of foodborne Campylobacter spp. cases in the Australian community would be expected to drop from approximately 8,400 to 3,864 cases per million, leading to a decline in the incidence of sequelae from 1,620 to 870 cases per million per year.

In addition to Campylobacter spp., norovirus, ‘other pathogenic E. coli’, and non-typhoidal Salmonella spp. were the main contributors to the incidence of foodborne illness. Reducing the number of cases of these illnesses in the community would reduce the societal burden of foodborne gastroenteritis. Meats, particularly chicken meat, and eggs have been shown to be important food sources for infections due to Campylobacter spp., non-typhoidal Salmonella spp.,30-33 and in Australia, fish is the source of seafood toxins responsible for ciguatera and scombrotoxicosis.34 Generating robust attribution data to identify food sources for specific pathogens, as well as contributing factors throughout the production and supply chain may help target food safety policies and interventions.

Similar foodborne illness estimation studies have been conducted in the USA,5,6 UK,12 Canada,17 and the Netherlands.14 The proportion of gastroenteritis estimated to be due to foodborne transmission in the current study (25%) is remarkably similar to the UK estimate (26.2%) and the most recent USA estimate (25.8%), but lower than that of the Netherlands (39%). Although the Canadian study does not report an overall proportion foodborne, analysis of their results put it around 20%. In addition, the proportion of foodborne gastroenteritis due to unknown aetiology that was estimated in the USA (80%) is the same proportion that was estimated in this study. The overall estimates of the proportion that is foodborne depend on the selection of pathogens for inclusion, the incidence of common pathogens, and the estimated proportion that are foodborne.

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31Foodborne illness in Australia circa 2010

While this study builds on an earlier Australian study estimating the incidence of foodborne illness circa 2000, there have been a number of methodological improvements since then. Data from the OzFoodNet outbreak register were used for pathogens that are not included in the national surveillance system. National data from NNDSS were used to determine the proportion of cases that were associated with travel. Hospitalisation data from all jurisdictions and death data from the ABS were used to estimate the incidence of severe illness. Use of national data takes account of variation in foodborne illness patterns by state and territory, and provides more representative national estimates. Use of both principal and additional diagnosis data from hospitals more accurately captures hospitalisation patterns by pathogen.

A new expert elicitation undertaken in 2009 for this estimation effort was incorporated, further improving data quality.23,35 The proportion of foodborne transmission was generally estimated to be lower and uncertainty bounds wider, compared to the estimates found in the Delphi process in 2005. This may be a reflection of a general perception that environmental sources of infection have been somewhat neglected and that health departments have a primary focus on ‘foodborne disease’.23,35 These lower foodborne proportions translated into fewer illnesses, hospitalisations, and deaths being attributed to food, compared to the circa 2000 study.

In estimating community incidence, underreporting multipliers were used to adjust for the proportion of people who were infected with a pathogen or agent but did not seek treatment or submit specimens for testing. Following a 2008 study by Hall et al.,22 new multipliers were used for non-typhoidal Salmonella spp., Campylobacter spp., and STEC. The non-typhoidal Salmonella spp. underreporting multiplier of 7 (95% CI: 4–14) was extrapolated to all other moderate illnesses, besides Campylobacter spp. These new underreporting multipliers are smaller than the multiplier of 15 (CrI: 5–25) that was used in 2005.3 This is one of the main reasons that direct comparison between the estimates in circa 2000 and in circa 2010 can be misleading. However, application of these new multipliers to data circa 2000 has validated that there have been increases in the incidence of illness due to Campylobacter spp. and non-typhoidal Salmonella spp. between 2000 and 2010.

An underreporting multiplier for serious illnesses and the underdiagnosis multiplier for hospitalisations and deaths of two cases for every case reported was used,3,10 which is consistent with studies by Mead et al.5 and Scallan et al.6 The use of this multiplier for hospitalisations and deaths was supported by comparing data from the OzFoodNet outbreak register to hospital and ABS deaths data, which suggested that a multiplier of at least two was necessary to account for underdiagnosis. There are limited data on pathogen-specific underdiagnosis and further studies are required to thoroughly validate this multiplier and assess whether there are pathogen-specific differences in underdiagnosis of severe illness.

Another improvement in this study was the higher level of detail and research that went into the estimates for sequelae, including extensive literature searches and the addition of a bacterial multiplier in estimates of the foodborne proportion. Many of the international estimation efforts have not undertaken the task of estimating foodborne sequelae.5-7,12 The current estimation work revealed the additional burden from foodborne pathogens, such as Campylobacter spp., non-typhoidal Salmonella spp., and STEC, that is not seen when just looking at the incidence of acute illness. For instance, while foodborne Campylobacter spp. infection is directly responsible for three (90% CrI: 2–4) deaths each year, it also causes a further six (90% CrI: 2–10) deaths from GBS and is potentially responsible for deaths from other sequelae. Overall, Campylobacter spp. was responsible for around 80% of sequelae estimated in this study, highlighting the importance of control measures to reduce both acute and chronic illness from contaminated food.

Dis

cus

sio

n

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32

To validate the estimates of incidence, a primary and additional estimation method were used depending on the available data for each pathogen. When the additional approach estimates were similar to the primary approach, this validated the estimate and gave more confidence in the data. When the two approaches produced different estimates, this allowed for a closer examination of the data to determine which source was more reliable and should be used as the primary method. Using these two approaches gives us confidence that estimates were created using the best available data for each pathogen. One consequence of this was a reduction in estimates of incidence for Cryptosporidium spp. and G. lamblia in 2010 when compared with 2000, which reflect a methodological shift from the use of the 1997–1999 WQS data for these pathogens in 2000, to the use of notification data for these pathogens in 2010. Estimates circa 2010 used the Australian NNDSS for Cryptosporidium spp., and state data for Victoria for G. lamblia.

By applying the current estimation methods to the data from 1996–2000 (which were used for the circa 2000 report), there was an increase in estimates of foodborne Campylobacter spp. and non-typhoidal Salmonella spp. annual incidence by about 40,000 and 11,000 cases respectively from circa 2000 to circa 2010. This estimated increase is supported by the fact that notifications for both pathogens have been increasing over the 10 year period and higher numbers of hospitalisations were observed in 2010 when compared with 2000. In addition, the circa 2010 estimates for GBS and other sequelae increased over this time. These increases are concerning and highlight the importance of government and industry partnerships to reduce the incidence of specific foodborne pathogens,28,29 as well as the promotion of food safety education for consumers.

There was a clear decline in estimates for rotavirus in 2010 compared to 2000 reflecting the success of the immunisation program, which began in 2006, in reducing illness in young children.36 Similarly, estimated foodborne illness due to hepatitis A declined from 245 foodborne cases per year circa 2000 to 40 foodborne cases per year in 2010, reflecting improved public health control of this pathogen, such as vaccination programs in Indigenous communities and other interventions.37 While these vaccination programs were not targeting foodborne transmission of disease, these declines show the systemic effects that public health interventions can have and the benefits for food safety due to reduced infection pressure.

Overall foodborne gastroenteritis in Australia from the NGSII decreased when compared to the NGSI, which consequently reduced the estimate of overall foodborne gastroenteritis. The reduction in incidence of gastroenteritis may be due to a range of factors, including biases in the study methodology as the response rate decreased over time, or a true decrease in incidence of pathogens causing gastroenteritis, such as rotavirus.36

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33Foodborne illness in Australia circa 2010

Study limitationsIn a complex study of this type, there are many gaps in data availability and each data source had strengths and weaknesses. While NNDSS and the OzFoodNet outbreak register were nationally representative, there may have been differences in the way that jurisdictions reported or coded their data, and some outbreaks may not always be captured in the OzFoodNet outbreak register, such as those due to illnesses like hepatitis A and listeriosis, unless a source is identified.

In contrast, there may have been outbreaks or unusual increases in disease that occurred during the study period. In 2009, there was a large outbreak of hepatitis A associated with semi-dried tomatoes across Australia.38 Similarly, outbreaks of salmonellosis and other agents were routine occurrences.39 It was decided that data would not be adjusted in the estimation to account for outbreaks or investigated clusters, as these events represent the real situation of foodborne illness in Australia and form an important part of the burden of disease.

Data from the WQS2,20 were used for pathogens that were not nationally notifiable or had limited outbreak data (Technical Appendix 3, page 52). This study is the best of its kind in Australia, but is now over 15 years old. The study centred on families with children in the Melbourne area, and as such may not represent all foodborne illness in Australia. Where WQS data were used, changes over time and the differing age structure to the general population were adjusted for. Participation and stool submission in the study may also be an issue: only about one third of gastroenteritis cases submitted a stool sample, not all ‘known’ pathogens were tested for, and only 17% of stools that were examined had a pathogen identified.2,20

One aspect of using WQS data is that the estimate of the incidence of ‘other pathogenic E. coli’ is very high. The WQS reported a high recovery rate from participants’ stool samples of enteropathogenic E. coli, at least some of which had atypical virulence characteristics.40 Apart from notifiable disease data on Shiga toxin-producing E. coli, there were no other data available on pathogenic E. coli from other sources. The public health significance of enteropathogenic E. coli is uncertain, as little is known about sources of infection in the community. Consequently, the range of uncertainty around the estimates of incidence of ‘other pathogenic E. coli’ is very wide. Given these concerns – and the lack of a second dataset for comparison – these estimates should be viewed with caution. It is also worth noting that hospitalisation rates for ‘other pathogenic E. coli’ were low, as this hospitalisation code is a generic category and laboratories are unlikely to test for pathogenic E. coli as a cause of diarrhoea.

While the study by Hall et al.22 provided a more appropriate underreporting multiplier for specific pathogens than was previously available, both the underreporting multiplier and the outbreak multiplier in the circa 2010 estimates were largely based on non-typhoidal Salmonella spp. Although pathogens responsible for moderate illness may act similarly to non-typhoidal Salmonella spp., in reality, multipliers are likely to be illness specific. Ideally, underreporting and outbreak multipliers would be specific to each pathogen.

Another limitation was the amount of research and data available for the proportion of diarrhoea that was due to astrovirus, adenovirus, and sapovirus. While they may cause gastroenteritis commonly, they are rarely tested for and laboratory tests are probably unreliable. In addition, sapovirus is a newly identified virus and hospitalisations and deaths could not be estimated as there was no ICD-10-AM code for the illness. The total envelope of disease resulting from these three pathogens estimated circa 2010 is similar to that estimated for adenovirus and astrovirus circa 2000, however the data to inform these estimates were sparse.

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34

This study attempted to account for many weaknesses in the data through the estimation of uncertainty. In this study, the uncertainty bounds were expanded from 95% credible intervals to 90% credible intervals. The main reason for doing this was to ensure consistency with international efforts.6 Wider credible intervals reflected greater uncertainty. When these intervals were examined, it was identified that over half the uncertainty arose from the distribution for the foodborne multiplier, with distributions for the underreporting and pathogen fraction multipliers the next most important sources of uncertainty.

The implication of this is that a massive change in the incidence of foodborne pathogens would need to be observed in order to see a significant difference in the rate ratio over time. When comparing rates from 2010 to 2000, only the incidence of hepatitis A was significantly lower, representing a seven-fold decrease. Studies targeted at high incidence pathogens—norovirus and ‘other pathogenic E. coli’ in particular—would help to reduce this uncertainty and improve understanding for disease prevention. Given the significant uncertainty in estimation methods, there is a need to improve the ability to detect less-dramatic changes in disease.

Policy implications and further researchFoodborne illness estimates are an important tool for public health policy as they elucidate the societal burden of foodborne illness, and allow economic assessment to determine the direct costs of illness from contaminated food. A costing report of the circa 2000 estimates suggested that foodborne illness in Australia costs AUD$125 billion dollars annually.4 Updating this figure for the circa 2010 estimates is important for understanding the direct costs of foodborne illness. In addition to the direct costs incurred, foodborne illness is also a significant public health issue due to the potential costs that food contamination and food recalls may have on industry. Outbreaks and sporadic illness occur from a variety of food commodities and many different industries and even whole economies can be affected.

A recent USA study found that most foodborne illnesses from outbreaks can be attributed to food commodities that constitute a major portion of the diet in the USA.41 As these types of commodities are frequently consumed, food contamination often leads to massive recalls, along with industry wide damage. These high costs demonstrate the public health importance of reducing foodborne illness and provide an opportunity for regulatory policy to reduce these common illnesses. The study by Painter et al.41 attributes outbreaks to food commodities in the USA. Similar studies in Australia to identify the food commodities responsible for the greatest amount of illness, as well as for contributing factors through the production and supply chain, could complement these estimates of incidence, hospitalisation and death and provide increased support for targeted interventions in the food industry.

There are several areas where further research is needed to strengthen the estimates and improve public health policy. Foodborne illness estimate and burden studies can assist with identifying vulnerable populations. For this, it is important to consider specific sub-studies to examine the specific foodborne burden affecting sub-populations, such as the young or the elderly. For these groups, certain pathogens have higher incidence and the ameliorable risk factors will be different. Another area that is needed to improve the understanding of foodborne illness in Australia is better validation of hospitalisations admission records and death certificates for potentially foodborne agents.

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35Foodborne illness in Australia circa 2010

Importantly, this report highlights the benefits of a large prospective community cohort study that follows participants for reports of symptoms of diarrhoea and/or vomiting, similar to the IID2 study in the UK1 to better identify rates of infectious intestinal disease rates in the community due to specific pathogens or agents. For pathogens that are not covered by the national surveillance system and not commonly seen in outbreaks (such as G. lamblia and ‘other pathogenic E. coli’), this report had to rely on the Melbourne WQS2 which is now 15 years old, and has other limitations mentioned previously. A large prospective cohort study would improve current estimates for infectious gastroenteritis and aid in determining the burden and causes of specific pathogens in the Australian community, along with identification of preventable risk factors.

Finally, it would be important to repeat this estimation exercise circa 2020 to examine changes in disease incidence over time. Ideally, there would be a well-articulated plan to improve the information base for this assessment.

ConclusionThere are an estimated 4.1 million (90% CrI: 2.3–6.4 million) cases of foodborne gastroenteritis occurring each year, along with 5,140 (90% CrI: 3,530–7,980) cases of non-gastrointestinal foodborne illness and 35,840 (90% CrI: 25,000–54,000) cases of sequelae. The majority of foodborne illness occurs as gastroenteritis, but non-gastrointestinal illness and sequelae are also important due to the fact that they result in hospitalisations and occasional deaths. Over time, the incidence of foodborne gastroenteritis decreased slightly, while salmonellosis and campylobacteriosis had increased. There is a need to improve the evidence-base in Australia to improve the understanding of foodborne illness by conducting research into specific pathogens and the overall causes of gastroenteritis through a large-scale cohort study. The results of this study should assist policy makers to advocate for improved regulation and control of foodborne illness.

Co

nclu

sio

n

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37Foodborne illness in Australia circa 2010

Technical Appendix 1: Further comparing foodborne illness internationallyIncidence of infectious gastroenteritisThe estimate of total infectious gastroenteritis incidence in the community may be made using either a prospective cohort study or a retrospective cross sectional study with recall of episodes of gastroenteritis in the previous weeks. These studies are usually run over one year to capture any seasonal effects. The prospective cohort study design requires participants to record symptoms relevant to gastroenteritis in a diary during the study period. The retrospective cross sectional study design usually involves surveying people by telephone with regard to their symptoms of gastroenteritis in the recent past.

It is important to note that the two different study designs may not give the same estimates of population incidence of disease. Retrospective cross sectional studies have tended to provide higher estimates of gastroenteritis rates than do prospective studies. Cross sectional studies gave incidence close to one case per person per year in the USA, Canada and Australia,18,42,43 while prospective cohort studies have resulted in incidence considerably less than one case per person per year at 0.19 and 0.27 episodes per person-year in two UK studies,1,44 and 0.28 in the Netherlands.45

In the second UK study, the IID2 study in 2008, both a population based cohort study and a population based cross sectional study were run deliberately to compare incidence from the two study designs using the same case definition.1 In the IID2 study, using 7-day recall in the retrospective telephone study, the incidence was 1,530 cases per 1000 person-years, which was five times higher than the rate estimated in the prospective cohort study (274 cases per 1000 person-years). When they used 28-day recall in the telephone study, the incidence was estimated at 533 cases per 1000 person-years, which was twice as high as the rate estimated in the prospective cohort study. It has been proposed that retrospective studies tend to result in higher estimates of morbidity due to ‘recall errors’.44,46 If the recall period is short and the illness severe, then the event is more likely to be memorable and over-reported; whereas if the recall period is long, the illness mild and less memorable, it is more likely to be underreported or even forgotten.

While prospective studies do not tend to have the same issue with recall errors, they can, however, suffer from the effects of reporting fatigue, which occurs when participants lose interest in reporting their symptoms, possibly leading to an underestimation of the disease rate.2,44,47,48 A decline in the reported rate of highly credible gastroenteritis was observed in two Australian studies as the study progressed.2,48 Hellard et al.2 suggest that one way to avoid this phenomenon may be to use a shorter observation period with a larger number of participants.

Although more expensive and longer than retrospective cross sectional studies, cohort studies generally include specimen collection that allows for direct estimation of the incidence of some specific pathogens. Hellard et al.2 used a randomised clinical trial with a cohort of study participants to give incidence rates to 16 known enteric pathogens.

Tech

nic

al A

pp

end

ix 1

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38

Besides study design, the case definition of gastroenteritis can greatly influence incidence estimates, as there is no standardised international case definition. When four different case definitions were applied to a given country, the result was four different incidence estimates for that country.49 This strongly suggests that valid comparisons cannot be made between studies that use different case definitions. Incidence of illness and cost estimates will also be influenced by different case definitions because they rely on estimates of incidence or number of cases. In the study by Majowicz et al.,49 the different case definitions were also shown to affect gender specific values and age distributions, the observed duration of illness (by 20%), and the proportion of cases seeking medical care and submitting stool samples for testing. The use of a standard symptom-based case definition by investigators would enable much better inter-country comparisons and global estimates of gastroenteritis incidence.

A further complication in defining an appropriate case definition for gastroenteritis arises with regard to respiratory symptoms. When a person presents with concurrent respiratory symptoms and symptoms of diarrhoea or vomiting, they could be due to respiratory infections, gastrointestinal infections, or both; however this distinction is rarely made.50 Analysis of population based studies in Australia, Canada and the USA has shown that respiratory symptoms occur frequently in persons with acute gastrointestinal symptoms (diarrhoea, vomiting or both), specifically 29% in Australia, 42% in Canada and 47% in USA.50 Hence, if the case definition of acute gastroenteritis is adjusted to remove cases with respiratory symptoms, there is a substantial decrease in the estimates of incidence of acute gastroenteritis. Therefore, when estimating the incidence of foodborne illness from population studies, it is important to give consideration to cases with gastrointestinal symptoms possibly arising from respiratory infections and to make appropriate adjustments. To date, no international consensus has been reached on whether all or some of such cases should be excluded from analyses.

In the previous estimation of the incidence of gastroenteritis in Australia, Hall et al.3 used a case definition which referred to moderate-to-severe illness, with ≥3 loose stools or ≥2 episodes of vomiting in a 24 hour period in the previous four weeks. Patients with concomitant respiratory symptoms were excluded unless they had more severe symptoms of diarrhoea or vomiting, specifically, ≥4 loose stools or ≥3 episodes of vomiting, in a 24 hour period in the previous four weeks. In the Mead study5 respiratory symptoms were not excluded, but an adjustment was made to reduce the number of cases from a population based cross sectional study by 25% based on data from other studies to account for this.51,52 The case definition in the more recent study by Scallan et al.6 excluded persons with respiratory symptoms, which effectively halved the incidence rate of gastroenteritis.

Pathogens assessed in Australia circa 2000There are in excess of 200 different pathogens and agents that may be transmitted by contaminated food and cause gastroenteritis or other syndromes and conditions, such as hepatitis and septicaemia.5 Foodborne pathogens include viruses, such as norovirus and hepatitis A; bacteria, such as non-typhoidal Salmonella spp., Campylobacter spp. and toxigenic E. coli; along with toxins, such as ciguatoxins and histamines.6,8 The Australian study by Hall et al.10 included 16 infectious agents causing gastroenteritis, five pathogens or agents causing acute non-gastrointestinal illness, and four syndromes representing sequelae of acute foodborne infections. The key rationale for covering different pathogens in this study included: high incidence, severe outcomes of infection or exposure, availability of data, strong relationships with specific food vehicles, and expert opinion on importance to food safety.

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39Foodborne illness in Australia circa 2010

Estimating incidence of specific pathogensThe variation in methods used to estimate incidence of illness due to specific pathogens is largely data driven. Different methods have been used in different countries and across different pathogens, depending on what data are available. In many cases there are no ‘definitive’ data that give an absolute value of incidence, and varying adjustments and assumptions are usually required to estimate the incidence in the population. Data sources include cohort studies and surveys with laboratory testing of stool or other relevant specimens to identify pathogens, surveys with collection of human sera to identify antibodies to particular agents, surveillance systems of individual cases of illness due to various pathogens, or surveillance of outbreaks and data on hospitalisations and deaths. If there is more than one data source available then this allows for validation across different methods of estimation.

Population based prospective cohort studies are used to assess the incidence of all gastroenteritis and they also allow for stool specimens to be tested from those participants exhibiting relevant symptoms. This means the pathogens can be identified allowing estimation of the incidence of specific pathogens. This has given very useful results that have been used in burden studies in the Netherlands,14,45 in the first study of infectious intestinal disease (IID1) and in the IID2 study in the UK.1,44 The identification of known pathogens in specimens from population based cohort studies is often not complete, generally being found in around 30–50% of specimens. Numbers of cases also tend to be small and confidence intervals may be wide.

Active or mandatory laboratory based surveillance data maintained by health departments or other organisations are often used in the absence of cohort data and, depending on quality, are generally preferentially used above some other data sources. In countries like the USA and Australia, there may be more than one surveillance system operating, where there is surveillance to a national notifiable diseases system, and an enhanced surveillance system focussed on foodborne illness where reporting of cases is actively followed up, such as FoodNet.5,6,53 The number of cases reported to laboratory based surveillance is usually less than the number of cases in the community and multiplicative factors are used to adjust the numbers of reported cases to reach a more realistic estimate of incidence in the community. Multiplicative factors include adjustment factors to account for coverage of the population under surveillance (necessary when only a proportion of the population may be under enhanced surveillance), to adjust for the fact that only a proportion of cases go to the doctor and of these, only a proportion have a stool test ordered. Of these not all will have a positive test result depending on the sensitivity of the laboratory test, and further adjustment may be needed to account for incomplete reporting of positive tests to the surveillance system. Where only outbreak surveillance data are available, a further multiplicative factor is required to adjust from the number of cases reported in outbreaks to the number of individual cases that would have been reported if the pathogen were under individual surveillance.

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Accounting for underreporting and underdiagnosisThe underreporting of illnesses to surveillance is widely recognised and strategies to deal with this range from simply noting the issue to deriving quantitative factors using varying levels of data and sophistication. The calculation of community incidence from laboratory based surveillance data requires multipliers that account for the fact that not all cases in the community are reported. For this to happen, a person must have symptoms, visit a doctor, have a stool sample taken, the laboratory test has to be positive and the result reported to surveillance. Each of these steps can be assigned a probability based on the proportion of people or tests that proceed to the next step. The overall proportion of individuals recorded by surveillance is the product of all these component probabilities and the multiplier is the inverse of that proportion. The sequence of steps is commonly known as the reporting pyramid. The corresponding multiplicative factors comprise the components ‘population factor’, ‘doctor visit factor’, ‘stool test factor’, ‘laboratory sensitivity factor’, ‘reporting to surveillance factor’ and ‘outbreak factor’. In different studies these factors may have been estimated from ‘opinion’ or on more substantial evidence from various data sources.

In recent studies, more attention has been paid to trying to estimate these multipliers in a more pathogen-specific and evidence-based way and including measures of uncertainty. In the study by Mead et al.,5 multipliers were based on limited evidence and some multipliers were simply based on the authors’ opinions. In the more recent USA study,6,7 considerable effort was put into improving multipliers through the use of data to derive estimates and the modelling of uncertainty. An underreporting multiplier, comprised of a ‘population factor’, ‘reporting to surveillance factor’ and ‘outbreak factor’; and an underdiagnosis factor, comprised ‘doctor visit factor’, ‘stool test factor’, and ‘laboratory sensitivity factor’ were used to account for underreporting. The data for the multiplier that adjusts for passive to active surveillance were taken from pathogens that have both passive and active surveillance, including Cryptosporidium spp., STEC, L. monocytogenes and non-typhoidal Salmonella spp. To estimate the underdiagnosis factor, three population surveys of gastroenteritis were used to estimate the proportion of people who had bloody diarrhoea and sought medical care (35%), the proportion who then submitted a stool sample (36%), and the proportion of people who had non bloody diarrhoea and sought medical advice and then submitted a stool sample (18% and 19% respectively). For severe invasive illness it was assumed that 100% of cases would seek medical care and 80–100% would have a specimen test. A factor to account for the percentage of laboratories that tested for a particular pathogen was derived from FoodNet and other laboratory surveys and gave pathogen-specific factors of 25% to 100% and factors to account for sensitivity of the test of 28% to 100%. For the five pathogens with only outbreak data, the underdiagnosis factor was assumed to be the same as for non-typhoidal Salmonella spp. The outbreak factor to adjust for outbreak data to active surveillance was derived from ratios from pathogens with both active surveillance and outbreak surveillance.

In Hall et al.,3 most of the pathogen-specific incidence rates were based on methods using either direct estimation from cohort data from a study in Melbourne, Victoria,2,20 or surveillance data adjusted for underreporting using multipliers. The multipliers used to adjust for underreporting cases in the community to individual surveillance were: 15 (CrI: 5–25) for moderate illnesses, nine (CrI: 1–17) for bloody diarrhoea, and two (CrI: 1–3) for serious illnesses. The outbreak factor was estimated from cases infected with non-typhoidal Salmonella spp. in Victorian data that were reported to outbreak surveillance compared with the number of cases reported to individual surveillance, a factor of about 14. A method similar to that used by Voetsch et al.54 was used to calculate the underreporting factor of 15 for moderate illness using data from an unpublished case control study of non-typhoidal Salmonella spp. cases in the Hunter region and surveillance data (1997–2000). Comparison of the incidence of cases of non-typhoidal Salmonella spp. notified to the estimated incidence of non-typhoidal Salmonella spp. from the Melbourne water quality study (WQS)2 also informed this factor of 15.10 The ‘serious illness factor’ of two was based on the precedent set by the Mead et al.5 study.

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41Foodborne illness in Australia circa 2010

In 2008, new underreporting factors for Australia were estimated together with uncertainty for non-typhoidal Salmonella spp. at seven (95% CrI: 4–16), for Campylobacter spp. at 10 (95% CrI: 7–22), and for STEC at eight (95% CrI: 3–75).22 The multipliers resulted in estimates of community incidence of these pathogens that were lower than the estimates used in the last Australian foodborne illness incidence study.3 It is notable that the recent Australian underreporting factor estimates are similar to the recent UK estimates from the IID2 cohort study where underascertainment ratios for non-typhoidal Salmonella spp. and STEC were nine and seven respectively.1 The underascertianment ratio of five for Campylobacter spp. in the IID2 study was lower than the Australian underreporting estimate of 10.

Estimating hospitalisations and deathsAlthough the incidence of hospitalisations and deaths are important indicators of the severity of foodborne gastroenteritis, it is not easy to estimate them accurately. This is in large part because most routine surveillance systems underreport mortality from infectious diseases. In addition, very little information is collected on illness outcome by pathogen-specific surveillance.

National data on outpatient visits resulting in hospitalisation, hospital discharges and death certificates generally underestimate the pathogen-specific incidence. This is because pathogen-specific diagnoses need to be recorded, health care providers need to order appropriate diagnostic tests, and coding must be accurate. Scallan et al.6 used surveillance data to determine the proportion of persons that were hospitalised and the proportion that died, and then applied these proportions to the estimated number of laboratory confirmed illnesses. The number of hospitalisations and deaths was then doubled to account for underdiagnosis of those with unconfirmed illnesses.

Mead et al.5 also accounted for underreporting by doubling the number of hospitalisations and deaths among reported cases. Multiple cause of death data from the National Vital Statistics System where acute gastroenteritis was listed as the underlying or a contributing cause, were used to estimate the number of deaths. Acute gastroenteritis was defined by the following ICD-10 diagnostic codes: A00.9–A08.5 (infectious gastroenteritis of known cause), A09 (diarrhoea and gastroenteritis of presumed infectious origin), and K52.9 (non-infectious gastroenteritis and colitis, unspecified). A04.7 (enterocolitis due to Clostridium difficile) and A05.1 (botulism) were excluded. Mead et al.5 also excluded diagnoses of infectious enteritis associated with respiratory symptoms or a diagnosis of influenza (ICD-9-CM code 487).

In Australia, Hall et al.3 used data from the National Hospital Morbidity Database to estimate the total number of hospitalisations and deaths for each of the pathogens under investigation. In the Netherlands, de Wit et al.45 used linear regression to combine laboratory data and hospital registration data to obtain estimates for incidence of hospitalisations for rotavirus infection, only taking into account those with microbiologically confirmed rotavirus infection. In Canada, Ruzante et al.55 estimated the number of hospitalised cases and the fatalities from four years of data from the Canadian Institute for Health Information Hospital Morbidity Database (HMDB) and the Canadian Vital Statistics-Death Database for five enteric pathogens and three sequelae. Vaillant et al.,11 Mead et al.5 and Adak et al.12 applied pathogen-specific case fatality ratios, from selected outbreaks and studies, to the estimated number of cases. Their estimates do not relate to all directly coded deaths, which may have led to overestimation of the number of deaths attributable to foodborne infection.

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42

Estimating proportion of illnesses that are foodborneA key component of all studies examining the incidence and burden of foodborne illness is the estimation of the proportion of disease due to food for different pathogens or agents.56 This is important, as for many agents, disease may be acquired from exposure to a range of different sources, including contaminated food or water, infected animals or humans and contact with contaminated environments.57 Many enteric diseases are faecal-oral spread and may be transmitted via a range of different modes of transmission.8

Estimating the proportion of cases of disease due to different modes of transmission is difficult due to the paucity of data and is a weak point of studies assessing foodborne illness incidence.6,57 Public health investigators have used several different methods for assessing the fraction of disease that may be due to contaminated foods. Source attribution studies, which specifically examine the route of transmission, may be focused on different points in the food chain.57 Different approaches to studying source attribution include: microbiological approaches, epidemiological approaches, intervention studies, and expert elicitation. All national-level studies examining the incidence of foodborne illness have incorporated some element of source attribution to arrive at estimates of disease incidence. Investigators have used a range of these different approaches (Table T1.1).

An estimate of the proportion of transmission of known pathogens that is due to food is critical for estimation of the incidence of foodborne illnesses of unknown aetiology, which comprises the majority of the total burden. Even when using the most sensitive diagnostic screening tests, a recognised pathogen is recovered from only 30–40% of specimens.1 Only the UK, USA, Greek and Australian studies estimating the incidence of foodborne illness have taken gastroenteritis of unknown aetiology into account, following the approach adopted by the Mead study.3,5,7,12,13

Many foodborne illness incidence studies, including the circa 2000 estimates for Australia, have relied on expert elicitation to attribute illnesses to foodborne spread, due to the paucity of other sources of data on the mode of transmission. There have been several methodological improvements over the years to the expert elicitation framework, including providing experts with prior information from systematic reviews of the literature and modelling uncertainty in expert opinions using Monte Carlo simulation. This technique is fairly widespread in risk analysis studies and involves simulating distributions of components used in the calculations rather than using point estimates. The end product is a final distribution that provides a central point estimate and a credible interval.

However, there have been expert elicitations where the findings have proven unusual or contradictory.58 One Canadian study that used cluster analysis to examine opinions from experts from different backgrounds found that for L. monocytogenes, one group of experts had a mean of 8% of human infections were foodborne, compared to another cluster estimating 84% of human infections were foodborne.58 These differences may result from the type of expert selected, or from the prior information given to participants in these structured elicitations.

Expert elicitation should be regarded as a structured way to obtain a consensus opinion, based on evaluation of all available data. It cannot be expected to provide an unbiased estimate of the relative importance of different transmission routes. An advantage of expert elicitation is that it allows for information from different sources to be combined in a single analytical framework.

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43Foodborne illness in Australia circa 2010

Estimating uncertaintyThere are many sources of uncertainty in national incidence of disease studies including: uncertainty in the proportion of illness caused by specified or unknown pathogens, uncertainty in the proportion of cases that can be attributed to foodborne transmission, uncertainty in the level of underreporting of cases of illness, inconsistency in the quality of incidence data, and value choices made in the DALY formula. Furthermore, norovirus and other viruses are suspected of being responsible for a significant proportion of the ill-defined intestinal infections and hence have a major impact on overall estimates, but are poorly captured by routine surveillance.

It is important to try to express uncertainty quantitatively in order that reported estimates and intervals convey the message that foodborne illness estimations rely on a number of assumptions, and on data that are often variable, incomplete or minimal. While the study by Mead et al.5 did not attempt to quantify uncertainty, a number of other more recent studies have done so. The main method used to account for uncertainty is through Monte Carlo simulation.

The study that has the most extensive descriptions of the techniques to account for uncertainty used is the recent USA estimation of foodborne illness by Scallan et al.6,7 In this study the rationale for the type of distributions selected is given, and the resultant final estimates are given as a mean and 90% credible interval. This study provides the most thorough reasoning for the approach used and also sufficient detail in appendices to replicate their methods.

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44

.

Tab

le T

1.1:

Pro

po

rtio

n o

f illn

ess

es

att

rib

ute

d to

foo

d fo

r d

iffe

rent

pa

tho

ge

ns fr

om

na

tiona

l stu

die

s. N

ote

tha

t no

t a

ll p

ath

og

ens

or

ag

ent

s

co

nsid

ere

d in

the

se s

tud

ies

have

be

en

incl

ude

d in

the

co

mp

ari

son

tab

le. A

da

pte

d fr

om

Ha

vela

ar

et a

l.59

Ch

ara

cte

ristic

s o

f n

atio

na

l stu

die

sM

ea

d5

Ad

ak12

Vaill

an

t11H

all3

Ha

vela

ar59

Sca

llan

6G

kog

ka13

Tho

ma

s17

Co

un

try

USA

UK

Fra

nc

eA

ust

ralia

Ne

the

rlan

ds

USA

Gre

ec

eC

an

ad

a

Perio

d19

90s

1992

–200

019

97–2

000

2000

2006

2000

–200

819

96–2

006

2000

–201

0

Da

ta s

ou

rce

s*E/

O/R

OE/

O/R

/CC

/LE/

O/R

/LE

E/O

/R/L

LE/

O/R

/L

Tra

vel-r

ela

ted

ca

ses

Inc

lud

ed

Exc

lud

ed

Inc

lud

ed

Exc

lud

ed

Inc

lud

ed

Exc

lud

ed

Inc

lud

ed

Exc

lud

ed

Ca

mp

ylo

ba

cte

r sp

p.

80%

80%

80%

75%

42%

50%

55%

68%

STEC

50%

65%

51%

NA

O15

785

%63

%N

AN

A40

%68

%N

AN

A

No

n-O

157

85%

NA

NA

NA

42%

82%

NA

NA

List

eria

mo

no

cyto

gen

es99

%99

%99

%98

%69

%99

%99

%84

%

Salm

on

ella

sp

p.,

n

on

-typ

ho

ida

l95

%92

%95

%87

%55

%94

%95

%80

%

Baci

llus

cere

us

toxi

n10

0%10

0%10

0%10

0%90

%10

0%N

A10

0%

Clo

strid

ium

per

frin

gen

s10

0%94

%10

0%10

0%91

%10

0%N

A10

0%

Sta

phy

loco

ccu

s a

ure

us

100%

96%

100%

100%

87%

100%

NA

100%

He

pa

titis

A v

irus

50%

NA

5%10

%11

%7%

8%7%

No

rovi

rus

40%

11%

14%

25%

17%

26%

NA

31%

Rota

viru

s1%

3%N

A2%

13%

<1%

NA

1%

Cry

pto

spo

ridiu

m s

pp

.10

%6%

NA

10%

12%

8%5.

6%9%

Gia

rdia

lam

blia

10%

10%

NA

5%13

%7%

10%

7%

Toxo

pla

sma

go

nd

ii50

%N

A50

%35

%56

%50

%50

%50

%

*Da

ta s

ou

rce

s: E

=Exp

ert

op

inio

n; O

=Ou

tbre

ak

rep

ort

s; R

=Re

po

rte

d c

ase

s; C

C=C

ase

co

ntro

l stu

die

s; L

=lite

ratu

re s

ea

rch

N

A –

No

t ap

plic

ab

le

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45Foodborne illness in Australia circa 2010

Technical Appendix 2: National Gastroenteritis Survey IIThe National Gastroenteritis Survey II (NGSII) was conducted by the Australian Government Department of Health, the New South Wales Food Authority and the National Centre for Epidemiology and Population Health (NCEPH) in 2008–2009. The main aim of the survey was to estimate the incidence and public health impact of gastroenteritis in Australia.

For the NGSII, a stratified sample was collected in each state and territory, with a larger sample collected from New South Wales and the Australian Capital Territory. During the 12 months of the study, the response rate for the telephone-based survey was 49.1% (7590/15456), which represents the proportion of successful interviews for all eligible residential households contacted. Overall, 50.9% (7867/15456) of eligible households refused to participate in the survey. The lowest response rate was 47.3% for Victoria and the highest was 54.0% for Tasmania. There were a total of 7,590 interviews conducted. Twelve respondents did not provide an age during the interview and were excluded from analysis, as data were unable to be weighted. Data were weighted to account for the two-stage sampling design for jurisdiction and household and data were post-stratified by age category and sex using 2006 census data to make data more representative of the Australian population.

A total of 555/7578 (7.3%) respondents reported experiencing diarrhoea or vomiting in the previous four weeks, equating to 25 million episodes of vomiting or diarrhoea each year in Australia, compared to 29 million cases in the 2001 National Gastroenteritis Survey (NGSI) (Table T2.1). The primary definition of gastroenteritis was met by 341 cases, which equates to 15.9 million cases of gastroenteritis in Australia in 2008–09, compared to 18.9 million cases of gastroenteritis in the NGSI. The weighted incidence of gastroenteritis meeting the case definition in the NGSII was 0.74 (95% confidence interval [CI]: 0.64–0.84) episodes per person per year.

Demographic features and seasonalityIn the NGSII, children under five years old reported the most gastroenteritis and people over the age of 65 years old were nine times less likely to report gastroenteritis than people aged less than five years old. Only people aged between 20–29 years old were similar to children under the age of five years old in regards to their experience of gastroenteritis (Figure T2.1).

Tech

nic

al A

pp

end

ix 2

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46

Table T2.1: Weighted number of cases of gastroenteritis and incidence meeting various case definitions in Australia in one year, NGSI & NGSII

Definition

NGSII-2008 NGSI-2001 α

Million cases per year (95% CI)

Cases per person per

year (95% CI)

Million cases per year (95% CI)

Cases per person per

year (95% CI)

Gastroenteritis meeting case definitionβ

15.9 (13.7–18.0) 0.74 (0.64–0.84) 18.9 (16.6–21.1) 0.97 (0.86–1.09)

Any diarrhoea or vomitingγ 24.8 (22.2–27.4) 1.16 (1.04–1.28) 29.0 (26.3–31.7) 1.49 (1.36–1.63)

Diarrhoea onlyδ 14.1 (12.1–16.1) 0.66 (0.57–0.76) 17.2 (15.1–19.3) 0.89 (0.78–1.00)

α– Data for NGSI-2001 analysed using same data weighting procedure as NGSII-2008.

β–Case definition of ≥3 loose stools and/or ≥2 vomits in 24 hours that was not due to a known non-infectious cause. If respiratory symptoms were also present, a case was required to experience ≥4 loose stools and/or ≥3 vomits in 24 hours and no non-infectious cause.

γ– Includes any person reporting symptoms of diarrhoea or vomiting and does not exclude cases due to non-infectious causes.

δ–Includes any person reporting ≥3 loose stools in 24 hours.

Figure T2.1: Weighted annual incidence of gastroenteritis by age group and sex in Australia, NGSII

Age category (years)

Epis

od

es

pe

r p

ers

on

pe

r ye

ar

0–4 5–9 10–19 20–29 30–39 40–49 50–59 60–64 65+

0

0.2

0.4

0.6

0.8

1

1.2

1.4

1.6

1.8

2

Females

Males

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47Foodborne illness in Australia circa 2010

People living in rural areas or on farms were significantly less likely to experience gastroenteritis (adjusted odds ratio 0.57; 95% CI 0.35–0.93). There was no significant difference in the proportion of respondents reporting gastroenteritis by Indigenous status (Table T2.2). There was also no significant difference in the proportion of respondents reporting gastroenteritis by sex, state or territory, level of education or income, size of household, or whether a person had health insurance or not.

Table T2.2: Four week period prevalence of gastroenteritis by demographic features in Australia, NGSII

Characteristic No. surveyed

Prevalence in previous four weeks

No. with gastroenteritis

Crude %Weighted %

(95%CI)

Sex

Female 4554 199 4.4 5.2 (4.3–6.2)

Male 3024 142 4.7 6.2 (5.0–7.5)

Age category (years)

0–4 249 42 16.9 12.1 (7.5–16.8)

5–9 249 16 6.4 6.3 (3.0–9.7)

10–19 497 20 4.0 5.6 (3.0–8.2)

20–29 507 47 9.3 9.1 (6.1–12)

30–39 802 53 6.6 6.1 (4.1–8.1)

40–49 1064 54 5.1 6.1 (4.2–8.0)

50–59 1374 52 3.8 3.5 (0–8.2)

60–64 755 25 3.3 2.7 (0–6.0)

65+ 2081 32 1.5 1.2 (0–5.9)

Geographical distribution by state and territory

NSW/ACT 2367 113 4.8 6.1 (4.9–7.3)

NT 869 53 6.1 7.2 (5.1–9.2)

Qld 869 42 4.8 6.5 (4.5–8.5)

SA 870 33 3.8 5.1 (3.3–7.0)

Tas. 868 38 4.4 5.2 (3.4–7.0)

Vic. 867 34 3.9 5.2 (3.3–7.1)

WA 868 28 3.2 4.5 (2.6–6.3)

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Characteristic No. surveyed

Prevalence in previous four weeks

No. with gastroenteritis

Crude %Weighted %

(95%CI)

Indigenous status

Non-indigenous 7406 330 4.5 5.7 (4.9–6.5)

Indigenous 161 10 6.2 5.1 (0.8–9.4)

Highest level of education in household

Primary 106 4 3.8 5.4 (0–13.3)

Years 7–10 1714 62 3.6 5.4 (3.7–7.2)

Years 11–12 1425 56 3.9 4.9 (3.3–6.6)

Apprenticeship 562 29 5.2 6.8 (3.6–10)

Diploma/certificate

1298 55 4.2 5.2 (3.4–6.9)

University 2222 124 5.6 6.2 (4.8–7.7)

Household income

≤$25000 1641 46 2.8 4.4 (2.7–6.2)

$25,000 to <50,000

1399 62 4.4 6.1 (4.2–8.0)

$50,000 to <100,000

2024 108 5.3 6.3 4.9–7.8)

≥$100,000 1452 81 5.6 5.8 (4.1–7.5)

Unknown income

1062 44 4.1 5.0 (3.2–6.9)

Health insurance status

Health insurance 4307 187 4.3 5.2 (4.2–6.1)

No insurance 3183 151 4.7 6.4 (5.1–7.6)

Unknown insurance

88 3 3.4 6.0 (0–13.1)

Urban or rural location

Urban/town 6411 304 4.7 6.1 (5.2–7.0)

Rural/remote 1138 36 3.2 3.1 (1.7–4.5)

Table T2.2: Four week period prevalence of gastroenteritis by demographic features in Australia, NGSII (continued)

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Characteristic No. surveyed

Prevalence in previous four weeks

No. with gastroenteritis

Crude %Weighted %

(95%CI)

Number of people in household

1 person 1736 47 2.7 3.1 (1.9–4.3)

2 people 2768 100 3.6 5.6 (4.1–7.0)

3 people 1064 66 6.2 6.4 (4.4–8.4)

4 people 1226 80 6.5 6.8 (4.9–8.6)

5 people 519 36 6.9 7.7 (4.8–10.5)

6 or more people

231 12 5.2 3.2 (0.7–5.7)

Symptoms and duration The most common symptoms amongst cases were diarrhoea (87%), followed by loss of appetite (75%), nausea (66%) and stomach cramps (63%) (Table T2.3). Approximately one in four cases reported upper respiratory symptoms of sore throat, cough or runny nose. These cases fulfilled the stricter criteria of at least four loose stools or three vomits within a 24 hour period. Blood in stools was reported by 3.5%. The majority of cases had vomiting and/or diarrhoea for one or two days, and 6.5% of cases experienced symptoms for at least a weak. The estimated median duration of gastroenteritis was two days (interquartile range 1–3 days) and a mean of 3.5 days (95% CI: 2.9–4.1). Cases who experienced vomiting either in isolation or in combination with diarrhoea tended to have a shorter duration of symptoms.

Healthcare seeking behaviourTwenty-eight per cent of respondents who reported gastroenteritis sought some kind of health professional advice or treatment for their symptoms (Table T2.4). A total of 94 cases visited at least one healthcare facility for their illness, which would equate to 4.77 million (95% CI 3.55–5.99 million) visits each year, with 2.71 million (95% CI: 1.8–3.62 million) of these visits to a doctor.

Cases with gastroenteritis lasting two or more days were more likely to see a doctor compared to those who were ill for one to two days. The presence of vomiting and ear ache were significant predictors of cases going to see a doctor, as well as indigenous status (odds ratio (OR) 7.02, 95% CI: 1.38–35.8). People with stomach cramps were less likely to seek medical attention.

Of the cases that had diarrhoea only and saw a doctor, approximately 24% were asked to submit a stool specimen. Of those who were asked to submit a stool sample, 11 out of 12 cases subsequently submitted a specimen. Duration of illness of five days or more was associated with higher likelihood of a case submitting a specimen (OR 4.4, 95% CI: 1.96–9.87).

Around 37% of cases reported taking at least one medication to treat or relieve symptoms. This equates to about 5.5 million people taking medication for gastroenteritis each year. Approximately 6%

Table T2.2: Four week period prevalence of gastroenteritis by demographic features in Australia, NGSII (continued)

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of those taking medications were prescribed antibiotics, which after weighted analysis equates to an estimated 520,944 (95% CI: 54,699–987,189) courses of antibiotics that are prescribed in Australia for treatment each year.

Table T2.3: Unweighted and weighted proportion of cases with gastroenteritis reporting different symptoms in Australia, NGSII (n=341)

SymptomUnweighted Weighted %

(95% CI)

No. reporting Crude % Missing

Diarrhoea 298 87.4 0 84.1 (78.7–89.5)

Bloody stools 12 3.5 6 2.9 (0.8–4.9)

Loss of appetite 256 75.1 2 78.4 (72.7–84.1)

Nausea 225 66.0 6 66.7 (59.9–73.5)

Stomach cramps

216 63.3 9 64.5 (57.7–71.4)

Headache 142 41.6 13 45.3 (38.1–52.6)

Fever or chills 151 44.3 6 50.0 (42.9–57.1)

Vomiting 161 47.2 0 49.8 (42.7–56.8)

Muscle/body aches

135 39.6 16 43.4 (36.3–50.6)

Respiratory symptoms

87 25.5 3 29.2 (22.6–35.9)

Stiff neck 51 15.0 19 14.7 (9.8–19.6)

Ear ache 22 6.5 1 7.0 (3.7–10.3)

Table T2.4: Number of gastroenteritis cases seeking health careα in Australia, NGSII (n=94)

Health facility Number visiting %

Emergency/ casualty 12 3.5

Doctor’s surgery/health clinic 53 15.5

Pharmacy 49 14.4

Other 9 2.6

α Some cases may have sought care from more than one health facility.

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Missed work or activitiesGastroenteritis had a considerable impact on cases’ work, school and recreational activities in the survey, with 65% reporting that their illness interfered for a median of one day (range 1–30). Extrapolation from the data indicates that about 1.19 million days were lost from paid work each month, with 71% of instances where a person missed paid work due to the person being ill themselves and 29% due to another person having to care for a person with gastroenteritis.

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Technical Appendix 3: Data sourcesData sources used to calculate community incidenceHere, the data sources used to calculate community incidence of the 23 pathogens included in this assessment are described.

Data sources

There were three main sources of data: notifiable surveillance at the national or state and territory level, other surveillance through the OzFoodNet outbreak register, and estimates of incidence using the Australian gastroenteritis study60 together with cohort studies such as the Water Quality Study (WQS).2,20 The data source and estimation approach used for each pathogen is explained in Table T3.1.

Table T3.1: Data sources and estimation approach used for each pathogen or syndrome

Pathogen or syndrome Data sourceEstimation approach

CampylobacterSalmonella, non-typhoidalSalmonella TyphiShigellaCryptosporidiumHepatitis AListeria monocytogenes

National Notifiable Diseases Surveillance System (NNDSS) Notifiable

surveillance approach

Giardia lambliaShiga toxin-producing Escherichia coli (STEC)Vibrio parahaemolyticusYersinia enterocolitica

State and territory surveillance

Other pathogenic E. coliAdenovirusAstrovirusNorovirusRotavirusSapovirus

Water Quality Study 2,20

andNational Gastroenteritis Survey II 60

Pathogen fraction approach

Bacillus cereusClostridium perfringensStaphylococcus aureusCiguateraScombrotoxicosis

OzFoodNet outbreak registerOther surveillance approach

Toxoplasma gondii USA seroprevalence study 21Special calculations

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Notifiable surveillance: National Notifiable Diseases Surveillance System and state and territory notifications

The National Notifiable Diseases Surveillance System (NNDSS) provides national data for diseases that are notifiable in Australia, such as salmonellosis, shigellosis and cryptosporidiosis. Some diseases are notifiable in some states and territories, but not in others; for example, campylobacteriosis is not notifiable in New South Wales, but is notifiable in all other states and territories. In these cases, notification data were used for the available states and territories and include a population adjustment multiplier to estimate national notification rates (Technical appendix 4, page 54). In each case, the total number of confirmed notifications is used for all available years over the period 2006–2010.

Additionally, further data were requested through Communicable Diseases Network Australia (CDNA), who own the NNDSS data, to determine the proportion of cases that were acquired in Australia. Details of the use of these data are described below under the section ‘Domestically acquired multiplier’ (Technical Appendix 4, page 54).

Other surveillance: OzFoodNet outbreak register

The OzFoodNet outbreak register includes all outbreaks of foodborne gastrenteritis identified from 2000 and this study used data over the period 2006–2008. The register provides data on the number of individuals ill in each outbreak, the pathogen identified, and the total number of individuals with laboratory confirmed illness in each outbreak.

National Gastroenteritis Survey II 2008

The NGSII was a nationally representative telephone survey conducted February 2008 to January 2009 to estimate gastroenteritis incidence in Australia. It provides age-specific rates of gastroenteritis in the community (Technical Appendix 2, page 45).

Research studies

Australian and international cohort studies were used to assess the proportion of gastroenteritis that was due to specific pathogens. A key study was the 1997 WQS, which was a double-blinded, randomised, controlled trial of families conducted in Melbourne, Australia, between September 1997 and February 1999.2,20 Six hundred families were allocated to receive either real or sham water treatment units installed in their houses and study participants reported any gastroenteritis symptoms weekly. The study provides testing data on 795 faecal specimens identifying pathogens causing gastroenteritis, and these data were used to calculate a pathogen fraction multiplier for included pathogens. As there was no significant difference in incidence of gastroenteritis in control and experimental families, the study found that waterborne pathogens do not play a major role in gastroenteritis in Melbourne.2

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Technical Appendix 4: Approaches for calculating community incidence

Main approaches

Three main approaches were used for calculating the incidence of illness in the community. Where possible, a primary and secondary approach were applied to each pathogen to provide a cross-check of the results. The three approaches were based on the source of the data as:

1. Notifiable surveillance approach using data from NNDSS or state and territory notifications;

2. Pathogen fraction approach using data from the NGSII together with cohort studies, such as the WQS;

3. Other surveillance approach using data from the OzFoodNet outbreak register, or from hospitalisations.

These approaches were considered to form a hierarchy, with the notifiable surveillance approach used by preference, and outbreak data used only when other sources were not available. For each approach, the final estimate is produced from a statistical model that incorporated uncertainty in case numbers and in multipliers using probability distributions. That is, at each stage of the calculation, the estimate was represented by a probability distribution, and the final estimates and credible intervals were computed from this distribution.

In each approach, input data arises from specific data sources (discussed above), or from multipliers that are listed below. Three main input distribution types were used: empirical, pert, and lognormal.

Empirical distribution

Source distributions on the number of cases are typically represented by an empirical or discrete distribution driven by the data. For example, if the number of cases notified to NNDSS for the years 2006–2010 were 15,416, 16,980, 15,539, 16,075 and 16,967, this would be represented as a discrete distribution with 20% of the probability mass at 15,416, 20% of the probability mass at 16,980, and so on. This use of empirical distributions for such data was used previously by Scallan et al.,6 and avoids assumptions about the expected shape of this distribution.

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PERT distribution

The PERT distribution is widely used for expert elicitation and risk assessment studies. It is based on the beta distribution, and within @Risk (risk analysis software), can be specified either using a minimum, maximum and modal value, or by three percentile points, such as a median value and 95% credible intervals. This distribution is used widely in this analysis, as it allows for asymmetric distributions, and can be easily produced from many data sources including expert elicitation data.

Lognormal distribution

When re-calculating underreporting multipliers, the PERT distribution did not adequately capture the shape of these multiplier data. A lognormal distribution was adopted instead, as the distribution providing the best fit as measured by @Risk, and demonstrating an improved fit on the normal distribution used previously.22

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Technical Appendix 5: MultipliersMethods used to calculate community incidence

Multipliers

Approaches to calculating foodborne illness used key multipliers to either scale up (surveillance approaches) from detected cases to the full community incidence or scale down (pathogen fraction approach) from the envelope of all gastroenteritis to the proportion that was due to specific pathogens. Here, the multipliers used in this approach and the data that were used to derive these multipliers are described.

Population adjustment multiplier

This multiplier was used where notifiable surveillance data were not available for all states and territories in Australia, and was necessary to scale up the number of infections according to the proportion of the population covered by surveillance. For example, campylobacteriosis is notifiable in all states and territories except New South Wales. In this example, the total number of cases was adjusted for the remaining states and territories by a population adjustment multiplier of 1.5 to approximate the total number of cases that would be expected if all states and territories undertook notifiable surveillance of campylobacteriosis.

Domestically acquired multiplier

For some pathogens, a proportion of cases acquired their infections overseas. As data from the WQS used for the pathogen fraction calculations were centred on families, it was assumed all these incident cases were domestically acquired. For Campylobacter spp., Cryptosporidium spp., hepatitis A, L. monocytogenes, non-typhoidal Salmonella spp., Salmonella Typhi, Shigella, and STEC, the domestically acquired multiplier was calculated from NNDSS data on the proportion of cases that acquired their infection within Australia. These data contained a number of missing entries, varying by pathogen, state or territory and year, with the most complete data for Victoria and Western Australia. Four methods were considered for adjusting for this missing data:

1. Extrapolate travel patterns from Western Australia to the Northern Territory and travel patterns from Victoria to all other states and territories;

2. Extrapolate travel patterns from Western Australia to both the Northern Territory and Queensland, and travel patterns from Victoria to all other states and territories;

3. Discard all missing data and calculate the proportion of cases acquired in Australia for the existing data only;

4. Assume all unidentified cases are domestically acquired.

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Method 1 was adopted as the primary approach, and the other methods were used as a comparison and to identify a range for the multiplier. Specifically, the median estimate was made using all five years of data combined, while the minimum and maximum value reflects the largest and smallest proportion estimated by all four methods over each year of 2006–2010. Table T5.1 presents the resulting parameters for the PERT distribution, including median value, minimum and maximum, together with the estimations used circa 2000. For Cryptosporidium spp., non-typhoidal Salmonella spp., and Shigella, estimates on the full data over 2006–2010 using methods 1 and 3 were reassuringly similar, while the expanded ranges reflect the yearly variability and sensitivity to missing data. Larger differences are seen for hepatitis A, Salmonella Typhi, and STEC. There were very few missing data for hepatitis A and Salmonella Typhi which raises confidence in these estimates. Only zero to two overseas acquired cases of STEC were recorded per year, and this is reflected in the higher estimate of domestically acquired infection for this pathogen. This multiplier was also used for calculations of hospitalisations and deaths for ‘other pathogenic E. coli ’.

Estimates for the domestically acquired multiplier for G. lamblia were made using Victorian data over 2006–2009,61-64 using the total proportion to derive the median and the variability over years to give a range. Domestically acquired multipliers for V. parahaemolyticus and Y. enterocolitica were calculated from Western Australian data in a similar manner using OzFoodNet Annual Reports from 2006–2010. Given the higher rate of overseas acquired infections in Western Australia as compared with other jurisdictions, the proportion from overseas was reduced for other states and territories using a multiplier of 0.72 based on data for non-typhoidal Salmonella spp. Even with this adjustment, the multiplier for V. parahaemolyticus is much lower than that used in the USA suggesting a greater proportion of overseas-acquired cases in Australia;6 more information on the behaviour of this pathogen in states and territories outside Western Australia would be valuable to confirm these results.

Finally, it was assumed that all cases of adenovirus, Bacillus cereus, ciguatera, C. perfringens, L. monocytogenes, norovirus, rotavirus, scombrotoxicosis, Staphylococcus aureus, and T. gondii were acquired in Australia. Domestically acquired multipliers were not needed for the remaining pathogens (astrovirus and sapovirus) for which incidence was calculated using the pathogen fraction approach, and that do not have specific codes to calculate hospitalisations and deaths.

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Table T5.1: Circa 2010 estimates and ranges for the proportion of infections that were domestically acquired compared to the previously published estimates circa 2000, where available

Pathogen Estimate circa 2010 (range) Estimate circa 200065

Adenovirus 100% (100% – 100%)

Bacillus cereus 100% (100% – 100%)

Campylobacter spp. 97% (91% – 99%) 96%

Ciguatera 100% (100% – 100%)

Clostridium perfringens 100% (100% – 100%)

Cryptosporidium spp. 97% (92% – 99%)

Giardia lamblia 85% (84% – 89%)

Hepatitis A 58% (42% – 77%)

Listeria monocytogenes 100% (100% – 100%)

Norovirus 100% (100% – 100%)

Other pathogenic E. coli 99% (93% – 100%)

Rotavirus 100% (100% – 100%)

Salmonella, non-typhoidal spp. 85% (70% – 95%) 92%

Salmonella Typhi 11% (2% – 25%)

Scombrotoxicosis 100% (100% – 100%)

Shigella 70% (45% – 84%) 60%

Staphylococcus aureus 100% (100% – 100%)

STEC 99% (93% – 100%) 79%

Toxoplasma gondii 100% (100% – 100%)

Vibrio parahaemolyticus 18% (0% – 33%)

Yersinia enterocolitica 90% (80% – 100%) 98%

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Underreporting multiplier

Only a fraction of community cases visit a health professional, have a sample taken and have their illness recorded in surveillance data. Using data from a 2008 paper by Hall et al.,22 underreporting multipliers were estimated based on lognormal distributions of seven (95% CrI: 4–14) for non-typhoidal Salmonella spp., 10 (95% CrI: 6.5–18.5) for Campylobacter spp., and eight (95% CrI: 3–18.5) for STEC. Where underreporting multipliers were needed for other pathogens, the non-typhoidal Salmonella spp. multiplier was applied except in the case of pathogens leading to very severe illness (hepatitis A, L. monocytogenes, and Salmonella Typhi) where the underreporting multiplier was assumed to be two (95% CrI: 1–3). Details of the choice of multiplier for each pathogen are provided in Technical Appendix 11 (page 80).

Foodborne multiplier

For most pathogens, the proportion of illness that is foodborne was estimated using data from Delphi based expert elicitations. For nine pathogens, a 2009 elicitation was used, and for another eight, a similar 2005 elicitation was used.23,35 The 2009 elicitation was informed by systematic reviews for each pathogen that included scientific literature, reports and surveillance data. The foodborne multiplier for sapovirus was extrapolated from elicited norovirus estimates, and used best judgement assumptions for three additional viruses and the two marine biotoxins. See table T5.2 for a listing of pathogens, multipliers and the data source for each. A comparison of these estimates with those used in prior studies is provided elsewhere.23 Expert elicitation data from 2009 included a best estimate and 90% CrI for Campylobacter spp., C. perfringens, STEC, ‘other pathogenic E. coli’, non-typhoidal Salmonella spp., Shigella, norovirus, hepatitis A, and L. monocytogenes. A PERT distribution was fitted to each expert’s assessment, fitting the best estimate as the median and setting the 90% CrI where possible. In a few cases, a PERT distribution could not be fitted in this way, and the best estimate had to be adjusted to be the mode of the distribution (if the median point was too close to an upper bound or lower bound), or an interval bound had to be adjusted to be a min or max if the PERT distribution led to values outside the interval 0 to 1. A combined empirical distribution was calculated by computing the point-wise mean value of individual uncertainty distribution for each expert. The median, 5th and 95th percentiles of this empirical distribution were then used to describe a final PERT distribution that was input into the relevant @Risk spreadsheet.

The 2005 questionnaire provided a best estimate from participants. To include uncertainty in this estimate, a 90% credible interval was generated about each estimate, assuming an upper bound 10 percentage points higher and a lower bound 10 percentage points lower. For example, an estimate of 30% foodborne was modelled as a PERT distribution with median as 0.3, 95% bound 0.4, and 5% bound 0.2. The exception to this was where estimates were too close to zero (or one) for this method. In these cases, symmetric estimates half the distance from zero (or one) were assumed. That is, an estimate of 5% foodborne was modelled as a PERT with median as 0.05, 5% bound as 0.025 and 95% bound as 0.075. The combined distribution was calculated as for the expert elicitation data. The 2005 expert elicitation did not achieve consensus for some pathogens; in particular, best estimates ranged from 2%–95% for S. Typhi, 5%–100% for V. parahaemolyticus, and 33%–90% for Y. enterocolitica. Given the variability arising from these expert data, the sensitivity of the results to the choice of distribution was tested by simulating the full empirical distribution of the foodborne multiplier for each of these pathogens, and comparing estimates of foodborne illness with those using the PERT distribution. In general, median estimates were little changed, but credible intervals were a little wider under the empirical distribution. The largest change was for Y. enterocolitica, where the estimate of domestically acquired foodborne illness was 1,150 (650–1,950) using a PERT distribution and 1,100 (350–2,050)

using empirical data.

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Outbreak multiplier

For pathogens not captured by notifiable surveillance or by cohort studies, data from outbreaks were used in the other surveillance approach. Only a fraction of cases are associated with outbreaks. The outbreak multiplier adjusted for this to estimate the total number of cases that would be captured if notifiable surveillance was in place for that pathogen. Many of the pathogens for which this method was used have a short duration of illness, and thus low rates of laboratory confirmation. To adjust for this, the multiplier was calculated based on total number of ill (but not necessarily lab confirmed) cases associated with a confirmed outbreak (where laboratory confirmation of at least one case or of a food source has been occurred). Non-typhoidal Salmonella was chosen as the reference pathogen for the outbreak multiplier as it has the most complete data. The outbreak multiplier was calculated as the ratio of the number of ill cases in outbreaks of non-typhoidal Salmonella spp. to the total number of laboratory confirmed domestically acquired cases of non-typhoidal Salmonella spp. in the NNDSS for the same year. For example, in 2008 there were 8, 316 laboratory confirmed cases of non-typhoidal Salmonella spp. in NNDSS, of which 85% (range: 70–90) were assumed to be acquired in Australia. The total number of ill cases associated with non-typhoidal Salmonella spp. outbreaks in 2008 was 524, giving an outbreak multiplier of around 13.5 for this year. Extending this approach to calculate multipliers for each year from 2006–2008, and for data for all years combined, an outbreak multiplier of 14, with range 5–20 is estimated.

Table T5.2: Estimates of the foodborne multiplier with 90% credible interval using PERT distributions for each of the 23 pathogens used in the circa 2010 study*

Pathogen/IllnessFoodborne multiplier with

90% CrIData source23,35

Adenovirus 0.02 (0.01–0.03) Assumption

Astrovirus 0.02 (0.01–0.03) Assumption

Bacillus cereus 1.00 (0.98–1.00) 2005 EE as PERT

Campylobacter spp. 0.77 (0.62–0.89) 2009 EE as PERT

Ciguatera 1.00 (1.00–1.00) Assumption

Clostridium perfringens 0.98 (0.86–1.0) 2009 EE as PERT

Cryptosporidium spp. 0.10 (0.01–0.27) 2005 EE as PERT

Other pathogenic E. coli 0.23 (0.08–0.55) 2009 EE as PERT

Giardia lamblia 0.06 (0.01–0.50) 2005 EE as PERT

Hepatitis A 0.12 (0.05–0.24) 2009 EE as PERT

Listeria monocytogenes 0.98 (0.90–1.00) 2009 EE as PERT

Norovirus 0.18 (0.05–0.35) 2009 EE as PERT

Rotavirus 0.02 (0.01–0.03) Assumption

Salmonella, non-typhoidal 0.72 (0.53–0.86) 2009 EE as PERT

Salmonella Typhi 0.75 (0.02–0.97) 2005 EE as PERT

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Pathogen/IllnessFoodborne multiplier with

90% CrIData source23,35

Sapovirus 0.18 (0.05–0.35) Norovirus multiplier

Scombrotoxicosis 1.00 (1.00–1.00) Assumption

Shigella 0.12 (0.05–0.23) 2009 EE as PERT

Staphylococcus aureus 1.00 (0.95–1.00) 2005 EE as PERT

STEC 0.56 (0.32–0.83) 2009 EE as PERT

Toxoplasma gondii 0.31 (0.04–0.74) 2005 EE as PERT

Vibrio parahaemolyticus 0.75 (0.05–0.96) 2005 EE as PERT

Yersinia enterocolitica 0.84 (0.28–0.94) 2005 EE as PERT

*EE = Expert elicitation

Gastroenteritis multiplier

For pathogens captured by cohort studies such as the WQS,2,20 a proportion of all gastroenteritis cases was attributed to that pathogen using the pathogen fraction approach. The first step of this approach was to determine the total incidence of gastroenteritis. To do this, the NGSII study was used to estimate the total number of gastroenteritis episodes per person per year, weighted by the Australian population. This estimate served to provide a gastroenteritis multiplier, which was then multiplied by the total Australian population for the years 2006–2010 to give the estimated number of cases of gastroenteritis for each year. The gastroenteritis multiplier was modelled as an alternative PERT distribution with median 0.74 and 95% confidence interval (0.64–0.84), based on the estimates and uncertainty intervals estimated by the NGSII study.

Pathogen fraction multiplier

The pathogen fraction multiplier attributed a proportion of the total number of gastroenteritis episodes to particular pathogens. The primary data source for this was the WQS.2,20 While data from the UK infectious intestinal disease (IID2) study1 was also used as a comparator, the WQS gave the most reliable picture of the incidence of illness due to different pathogens in Australia. The data from the study were age-adjusted (using age ranges 0–4, 5–14, 15+ years) to the Australian population (circa 2010) take account of the higher numbers of children in the WQS. For example, the raw data for adenovirus in the WQS was nine positive samples from a total of 713 samples taken from participants with a highly credible episode of gastroenteritis. However, eight of those positives were from participants aged 0–4 years old, an age group over sampled in the study. Using data on the incidence of gastroenteritis by age from the NSGII study, and the Australian population as a reference, age-adjusted estimates were calculated for each pathogen based on the WQS data. For example, for adenovirus, an estimate of four samples positive for adenovirus from 713 gastroenteritis episodes was derived. This resulted in a pathogen fraction multiplier of 0.0056 (95% CI: 0.0015–0.0143), which was then modelled in @Risk using an alternative PERT distribution. Note that the pathogen sheets provided

Table T5.2: Estimates of the foodborne multiplier with 90% credible interval using PERT distributions for each of the 23 pathogens used in the circa 2010 study* (continued)

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in Technical Appendix 11, page 80 provide the age adjusted estimates for each pathogen, so will differ slightly from studies reporting findings of the WQS.

Finally, no Australian cohort study that gave estimates of prevalence of astrovirus or sapovirus for all age groups could be found. Instead, the pathogen fraction multiplier from the WQS for adenovirus and norovirus, together with cohort data from children66,67 was used to calculate multipliers relating astrovirus to adenovirus, and sapovirus to norovirus. Although the use of children only in this approach is not ideal, it allowed the use of Australian data. An alternative approach using data from the UK IID2 study1 was also considered but was found to lead to unexpectedly high estimates for astrovirus and sapovirus that were not consistent with estimates for other viral pathogens estimated used data from the WQS. These differences perhaps arise from differences in the gastroenteritis case definitions in the UK IID2 study compared to the NGSII study conducted in Australia. The incidence of gastroenteritis in the NGSII study was almost fourfold higher than the IID2, which may indicate large differences in case definitions.

Time trend multiplier

The WQS was undertaken before the addition of a rotavirus vaccine to the national vaccination schedule in 2007. In calculating rotavirus incidence circa 2010, a time trend multiplier was included to adjust for the reduction in rotavirus in 2010 compared with pre-vaccination levels. In calculating this multiplier, data from a study of rotavirus hospitalisations by age before and after the introduction of the national vaccination program was used.36 By comparing age-specific hospitalisation rates in 2010 with that prior to vaccination, a time trend multiplier of 0.34 (95% CI: 0.32–0.36) was estimated in order to adjust for the decline in rotavirus notifications following vaccination.

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Technical Appendix 6: Other methods to estimate incidenceMethods to calculate community incidence

Toxoplasmosis – special calculations

The calculations for toxoplasmosis differed from all other methods, as seroprevalence studies were used to estimate yearly incident cases assuming a constant force of infection with age.21 While there is an Australian study of toxoplasmosis,68 the sample size was too small to rely on for this estimate. In adopting this USA study rather than European studies (see Pappas et al.69 for a systematic review), comparability is ensured with the circa 2000 estimates, and a conservative approach is taken to estimating Australian incidence of toxoplasmosis. This incidence estimate was then adjusted by a “proportion symptomatic” multiplier of 15% (90% CrI:11–21) in line with the approach by Hall et al. circa 200010 and that of Scallan et al.6

Unknown pathogens

The NGSII survey of gastroenteritis conducted in 2008–2009 was used to estimate the total envelope of domestically acquired gastrointestinal illness, and so calculate the incidence of unknown pathogens by subtracting the incidence of domestically acquired gastrointestinal pathogens from that of the survey. Credible intervals for unknown pathogens were estimated using @Risk, assuming all cases in the NGSII were domestically acquired. The foodborne multiplier for all known pathogens of 25% (90% CrI: 15–39) was calculated as a weighted average of the foodborne multiplier for each pathogen, weighted by the number of domestically acquired cases of each pathogen. Although this value is remarkably similar to that estimated by Scallan et al., it is worth noting that it is based entirely on Australian expert elicitation data, together with incidence calculations using Australian data, and so is entirely independent of that study. Examination of the two studies will identify differences in many components of the calculations. The foodborne multiplier was applied to unknown pathogens to estimate the total number of domestically acquired foodborne illness due to unknown pathogens, again using @Risk for credible intervals.

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Technical Appendix 7: Hospitalisations and deaths methodsData sourcesHospitalisation data from all Australian states and territories for 2006–2010 (where available), and deaths data from the ABS were obtained, using ICD-10 codes for deaths and ICD-10-AM codes for hospitalisations as in Table T7.1. Both astrovirus and sapovirus were excluded from this analysis as lacking appropriate codes. Patients were included as a hospitalisation if the appropriate code was included as the principal or an additional diagnosis. Table T7.2 shows the percentage of all hospital diagnoses that were listed as the principal diagnosis for each pathogen for 2010 (the year with most complete data). In the circa 2000 estimates,3,10 only data on principal diagnoses were used, with a multiplier of two (credible interval 1–3) for all pathogens to model both principal and additional diagnoses. It is clear form Table T7.2 that diagnosis patterns vary considerably by pathogen, so that use of both principal and additional diagnosis provides a more complete picture of hospitalisations.

Since only one year of hospitalisation data for Victoria and two years for New South Wales were available, it was necessary to extrapolate from these data to the remaining years to derive a distribution of the number of hospitalisations across all states and territories, which was modelled as an empirical distribution. In most cases, it was assumed the same number of hospitalisations each year, but some pathogens required further adjustment due to evident outbreak trends. For example, an outbreak of hepatitis A associated with sundried tomatoes coincided with the one year of hospitalisation data for Victoria. A ratio of hospitalisations in South Australia to Victoria was used to estimate Victorian hospitalisations for the missing years. As vaccination against rotavirus resulted in a decrease in incidence, hospitalisations, and deaths, post universal vaccination data, from 2008–2010 only, were used to estimate hospitalisations circa 2010.

EstimationTo calculate estimates of hospitalisations and deaths, a statistical model was used that incorporated uncertainty in case numbers and in multipliers using probability distributions. That is, at each stage of the calculation, the estimate was represented by a probability distribution, and the final estimates and credible intervals were computed from this distribution. Input data was obtained from specific data sources (discussed above) or from multipliers that are described below. A fuller description of these probability distributions is provided in the methods section for incidence.

Multipliers

Underdiagnosis multiplier

Recorded hospitalisations and deaths associated with each pathogen reflect only those individuals that have been tested and confirmed for the pathogen. Following previous studies, this was adjusted for using an underdiagnosis multiplier of two,5 including a distribution for the multiplier with range 1–3 as in Hall et al. and Scallan et al.3,6 The appropriateness of the multiplier for hospitalisations was

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confirmed as follows. Firstly, the OzFoodNet outbreak register was used to calculate the proportion of all ill cases associated with an outbreak that were hospitalised. This proportion was then compared to the ratio of incidence to hospitalisations both with and without the underdiagnosis multiplier. Although there was some variability by pathogen, overall, 3% of ill cases from 14 pathogens or illnesses in the OzFoodNet outbreak register were hospitalised. In contrast, the ratio of all incident cases to all hospitalised cases was around 0.01 when the underdiagnosis multiplier was included (and 0.005 otherwise). Although outbreak cases may be more severe than all incident cases (on average), and under-ascertainment of cases or under-recording of hospitalizations may have biased the validation of the multiplier, these results suggest that an underdiagnosis multiplier was appropriate. Further work would assist in better quantifying this multiplier.

Domestically acquired multiplier

This multiplier adjusted for the proportion of cases that acquired infection in Australia, and was adopted from the method for incidence. More details of the data and methods behind this multiplier are provided in the methods section for calculating incidence.

Foodborne multiplier

This multiplier adjusted for the proportion of illness that is foodborne using expert elicitation data, and was used for incidence, hospitalisations and deaths. Details are provided in the methods section for incidence.

Table T7.1: Mortality and hospitalisation codes for each pathogen

Pathogen or illness Mortality ICD-10 Code and description ICD-10-AM

Adenovirus A08.2: Adenoviral enteritis A08.2: Adenoviral enteritis

Bacillus cereus A05.4: Foodborne Bacillus cereus intoxication

A05.4: Foodborne Bacillus cereus intoxication

Campylobacter spp. A04.5: Campylobacter enteritis A04.5: Campylobacter enteritis

Ciguatera T61.0: Ciguatera fish poisoning T61.0: Ciguatera fish poisoning

Clostridium perfringens A05.2: Foodborne Clostridium perfringens intoxication

A05.2: Foodborne Clostridium perfringens [Clostridium welchii] intoxication

Cryptosporidium spp. A07.2: Cryptosporidiosis A07.2: Cryptosporidiosis

Guillain-Barré syndrome G61.0: Guillain-Barré syndrome G61.0: Guillain-Barré syndrome

Giardia lamblia A07.1: Giardiasis [lambliasis] A07.1: Giardiasis [lambliasis]

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Pathogen or illness Mortality ICD-10 Code and description ICD-10-AM

Hepatitis A* B15: Acute hepatitis A B15.9: Hepatitis A without hepatic coma

Haemolytic uraemic syndrome

D59.3: Haemolytic uraemic syndrome D59.3: Haemolytic uraemic syndrome

Irritable bowel syndrome

K58: Irritable bowel syndrome K58.0: Irritable bowel with diarrhoea

K58.9: Irritable bowel without diarrhoea

Listeria monocytogenes A32: Listeriosis A32.0–A32.9: Listeriosis

Norovirus A08.1: Acute gastroenteropathy due to Norwalk agent

A08.1: Acute gastroenteropathy due to Norwalk agent

Other pathogenic E. coli

A04.0: Enteropathogenic Escherichia coli infection

A04.1: Enterotoxigenic Escherichia coli infection

A04.2: Enteroinvasive Escherichia coli infection

A04.4: Other intestinal Escherichia coli infection

A04.0: Enteropathogenic Escherichia coli infection

A04.1: Enterotoxigenic Escherichia coli infection

A04.2: Enteroinvasive Escherichia coli infection

A04.4: Other intestinal Escherichia coli infections

Reactive arthritis* M02.1: Postdysenteric arthropathy

M02.8: Other reactive arthropathies

M02.1: Postdysenteric arthropathy, multiple sites

M02.3: Reiter’s disease, multiple sites

M02.8: Other reactive arthropathies, multiple sites

M03.2: Other postinfectious arthropathies in diseases classified elsewhere, multiple sites

Rotavirus A08.0: Rotaviral enteritis A08.0: Rotaviral enteritis

Salmonella, non-typhoidal*

A02: Other Salmonella infections A02.0–A02.9: Salmonellosis

Salmonella Typhi A01: Typhoid and paratyphoid fevers A01: Typhoid fever

Scombrotoxicosis T61.1: Scombroid fish poisoning T61.6: Scombroid fish poisoning

Shigella A03: Shigellosis A03.0–A03.9: Shigellosis

Table T7.1: Mortality and hospitalisation codes for each pathogen (continued)

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Pathogen or illness Mortality ICD-10 Code and description ICD-10-AM

Staphylococcus aureus A5.0: Foodborne staphylococcal intoxication

A05.0: Foodborne staphylococcal intoxication

STEC A04.3: Enterohaemorrhagic Escherichia coli infection

A04.3: Enterohaemorrhagic Escherichia coli infection

Toxoplasma gondii B58: Toxoplasmosis B58.0–B58.9: Toxoplasmosis

Vibrio parahaemolyticus

A05.3: Foodborne Vibrio parahaemolyticus intoxication

A05.3: Foodborne Vibrio parahaemolyticus intoxication

Yersinia enterocolitica A04.6: Enteritis due to Yersinia enterocolitica

A04.6: Enteritis due to Yersinia enterocolitica

Other* A04.8: Other specified bacterial intestinal infection

A04.9: Bacterial intestinal infection unspecified

A05.8: Other specified bacterial foodborne intoxications

A05.9: Bacterial foodborne intoxication unspecified

A07.8: Other specified protozoal intestinal diseases

A07.9: Protozoal intestinal disease, unspecified

A08.3: Other viral enteritis

A08.4: Viral intestinal infection, unspecified

A09: Diarrhoea and gastroenteritis of presumed infectious origin

T61.2 Other fish and shellfish poisoning

T61.8 Toxic effect of other seafood

T61.9 Toxic effect of unspecified seafood

T62: Toxic effect of other noxious substances eaten as food

T64: Toxic effect of aflatoxin and other mycotoxin food contaminants

A08.4: Viral intestinal infection, unspecified

A09: Diarrhoea and gastroenteritis of presumed infectious origin

A09.0: Other gastroenteritis and colitis of infectious origin

A09.9: Other gastroenteritis and colitis of unspecified origin

*Pathogens are starred if there are differences between the mortality codes (ICD-10) and the hospitalisation codes (ICD-10-AM)

Table T7.1: Mortality and hospitalisation codes for each pathogen (continued)

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Table T7.2: The percentage of all hospital diagnoses that were listed as principal for each pathogen, based on 2010 data for all states and territories

Pathogen or illness Percentage of all diagnoses listed as principal

Adenovirus 82%

Bacillus cereus 75%

Campylobacter spp. 79%

Ciguatera 83%

Clostridium perfringens 100%

Cryptosporidium spp. 59%

Other pathogenic E. coli 59%

Giardia lamblia 34%

Guillain-Barré syndrome 71%

Irritable bowel syndrome 69%

Haemolytic uraemic syndrome 30%

Hepatitis A 77%

Listeria monocytogenes 48%

Norovirus 37%

Reactive arthritis 50%

Rotavirus 77%

Salmonella, non-typhoidal 77%

Salmonella Typhi 93%

Scombrotoxicosis 100%

Shigella 76%

Staphylococcus aureus 100%

STEC 59%

Toxoplasma gondii 39%

Vibrio parahaemolyticus 50%

Yersinia enterocolitica 64%

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Hospitalisations and deaths due to unknown pathogensA large proportion of hospitalisations and deaths did not identify the source of infection (see “other” codes in Table T7.1). These data were adjusted and reported as follows for hospitalisations, with a similar approach used for deaths. Firstly, the total number of hospitalisations due to unknown pathogens was calculated from the appropriate codes. Hospitalisations that were attributed to known pathogens according to the underdiagnosis multiplier described above were then subtracted from this number. That is, where total numbers of known gastrointestinal pathogens were increased to adjust for underdiagnosis, this increase was subtracted from the total unknown gastrointestinal pathogens. A domestically acquired multiplier of one was assumed for unknown pathogens, but adjusted for the foodborne multiplier using an average of known pathogens, weighted by the number of hospitalisations for each pathogen. For hospitalisation data, this gave a foodborne multiplier of 44% (90% CrI: 38–50), and for death data, a foodborne multiplier of 51% (90% CrI: 36–71). Although Scallan et al.6 do not report their weighted foodborne multipliers for hospitalisations and deaths, analysis of their tables suggest their values are 24% for hospitalisations and 52% for deaths. As noted in Technical Appendix 2, the calculations here are entirely independent; the Australian hospitalisation estimate is considerably higher although the estimate for deaths shows good agreement.

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Technical Appendix 8: Methods for sequelae incidenceTo calculate community incidence of the four sequelae included in this assessment, namely Guillain-Barré syndrome (GBS), haemolytic uraemic syndrome (HUS), irritable bowel syndrome (IBS), and reactive arthritis (ReA), data were used from notifiable surveillance to estimate incidence of the causal pathogens, and adjusted using a sequelae multiplier modelled as a PERT distribution.

The approach to estimating sequelae-specific multiplier was to conduct a detailed search of studies in the literature, and base the circa 2010 estimates on these studies, using Australian studies and systematic reviews where possible. In literature searches, attention was confined to peer-reviewed studies published in English between 1995 and 2012. Specific keywords were used for each sequel to search PubMed. All types of studies were included; titles and abstracts were reviewed, and full text articles were obtained for all relevant studies.

Guillain-Barré syndromeCommunity incidence of Campylobacter spp. was estimated using NNDSS data, adjusted for non-notification in New South Wales as described in Technical Appendix 5 (page 56). Incidence of GBS was estimated by further adjusting the distributions for Campylobacter spp. by a sequelae multiplier estimated from values in published studies. Search terms for GBS included: “Guillain-Barré syndrome”, “incidence”, “Campylobacter” and “Australia”, with each selected paper including at least one search term. Four papers were identified that estimated the proportion of Campylobacter spp. cases that led to GBS, with the one by Baker et al.29 being excluded because it was only a study of hospitalised cases (Table T8.1). These studies were used to estimate a range for the sequelae multiplier of 0.000192 to 0.000945, with a midpoint value of 0.000304.

Table T8.1: References used to estimate the sequelae multiplier for Guillain-Barré syndrome – that is the proportion of Campylobacter spp. cases that result in GBS

Reference Study years Country# GBS cases

/campylobacteriosis patients

Baker et al.29 1995–2008 New Zealand 35 / 8,448 (0.4%)

Tam et al.70 1991–2001 UK 3 / 15,587 (0.019%)

McCarthy & Giesecke71 1987–1995 Sweden 9 / 29,563 (0.03%)

Allos72 1964–1996* Global/USA 1/1058 cases (0.0945%)

* Years of reviewed studies

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Haemolytic uraemic syndromeCommunity incidence of STEC infection was estimated using South Australian notifications, with multipliers to extend to the national population as described in Technical Appendix 5 (page 56). Incidence of HUS was estimated by applying a ‘sequelae multiplier’ estimated from published studies to STEC. Search terms for HUS included: “Haemolytic uraemic syndrome”, “HUS”, “incidence”, “STEC” and “E. coli”, with each selected paper including at least one search term. Several published studies reported that 3–7% of sporadic STEC infections resulted in HUS.73-76 Australian studies supported this range. Vally et al.77 examined South Australian surveillance data for a 13 year period where among the 460 cases of STEC notified, there were 14 reported cases of HUS, resulting in an estimate of 3.0% (95% CrI: 1.7–5.1) of STEC cases developing into HUS.

Irritable bowel syndromeCommunity incidence of Campylobacter spp., non-typhoidal Salmonella spp., and Shigella infections were estimated using NNDSS data as described in Technical Appendices 4 and 5 (pages 54 and 56). Incidence of IBS was estimated by further multiplying each incidence distribution by a ‘sequelae multiplier’ estimated from published studies. Search terms for IBS included: “irritable bowel syndrome”, “IBS”, “Post-infection irritable bowel syndrome”, “PI-IBS”, “incidence”, “Australia’, “Campylobacter”, “Salmonella” and “Shigella” with each selected paper including at least one search term. The sequelae multiplier for IBS was based on a meta-analysis conducted in the Netherlands by Haagsma et al.,78 who estimated that approximately 8.8% (90% CI: 7.2–10.4%) of bacterial cases of gastroenteritis go on to develop IBS 10 to 12 months after infection.

Reactive arthritisCommunity incidence of Campylobacter spp., non-typhoidal Salmonella spp., Shigella, and Y. enterocolitica infections were estimated using NNDSS data (Technical Appendices 4 and 5, pages 54 and 56). Incidence of ReA was estimated by multiplying incidence distributions for each of these by sequelae multipliers for each of these four pathogens. Search terms for ReA included “reactive arthritis”, “ReA”, “incidence”, “Australia”, “Campylobacter”, “Salmonella”, “Shigella”, and “Yersinia”. Table T8.2 lists studies used to estimate the sequelae multipliers following infection with each pathogen. From these studies sequelae multipliers of 0.07 (range: 0.028–0.16) for Campylobacter spp., 0.085 (range: 0–0.26) for non-typhoidal Salmonella spp., 0.097 (range: 0.012–0.098) for Shigella, and 0.12 (range: 0–0.231) for Y. enterocolitica were adopted.

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Table T8.2: References used to estimate the sequelae multiplier for reactive arthritis (ReA) for each of four pathogens: Campylobacter spp., non-typhoidal Salmonella spp., Shigella, and Y. enterocolitica

Reference Study years CountryReA cases/Gastroenteritis

cases

ReA cases/Campylobacter cases

Schonberg-Norio et al.79 2002 Finland 8/201 (4.0%)

Doorduyn et al.80 2005 The Netherlands 20/434 (4.6%)

Townes et al.81 2002–2004 USA 302/2384 (12.7%)

Schiellerup et al.82 2002–2003 Denmark 131/1003 (13.1%)

Pope et al.83 1966–2006 Europe 1 – 5%

Hannu et al.84 2000 Finland 9/350 (2.6%)

Rees et al.85 1998–1999 USA 9/324 (2.8%)

Hannu et al.86 1997–1998 Finland 45/609 (7.4%)

Locht & Krogfelt87 1997–1999 Denmark 27/173 (15.6%)

ReA cases/non-typhoidal Salmonella cases

Arnedo-Pena et al.88 2005 Spain 16/155 (10.3%)

Doorduyn et al.80 2005 The Netherlands 8/181 (4.4%)

Townes et al.81 2002–2004 USA 204/1356 (15.0%)

Schiellerup et al.82 2002–2003 Denmark 104/619 (16.8%)

Lee et al.89 1999 Australia 38/261 (14.6%)

Rees et al.85 1998–1999 USA 2/100 (2.0%)

Buxton et al.90 1999–2000 Canada 17/66 (25.7%)

Hannu et al.91 1999 Finland 5/63 (7.9%)

Locht et al.92 1999 Denmark 17/91 (18.7%)

Rudwaleit et al.93 1998 Germany 0/286 (0%) (Children only)

Dworkin et al.94 1994 USA 63/217 (29.0%)

McColl et al.95 1997 Australia 13/312 (4.2%) & 6/112 (5.3%)

Urfer et al.96 1993 Switzerland 1/156 (0.6%)

Mattila et al.97 1994 Finland 22/191 (11.5%)

Thomson et al.98 1984–1989 Canada 27/423 (6.4%)

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Reference Study years CountryReA cases/Gastroenteritis

cases

ReA cases/Shigella cases

Townes et al.81 2002–2004 USA 29/298 (9.7%)

Schiellerup et al.82 2002–2003 Denmark 10/102 (9.8%)

Rees et al.85 1998–1999 USA 1/81 (1.2%)

ReA cases/Yersiniosis cases

Huovinen et al.99 2006 Finland 6/61 (9.8%)

Townes et al.81 2002–2004 USA 5/35 (14.3%)

Schiellerup et al.82 2002–2003 Denmark 21/91 (23.1%)

Hannu et al.100 1998 Finland 4/33 (12.1%)

Table T8.2: References used to estimate the sequelae multiplier for reactive arthritis (ReA) for each of four pathogens: Campylobacter spp., non-typhoidal Salmonella spp., Shigella, and Y. enterocolitica (continued)

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Technical Appendix 9: Methods to estimate hospitalisations and deaths due to sequelaeHospitalisation data for 2006–2010 from all Australian states and territories for IBS and ReA, and death data for all four sequelae from the ABS was obtained, using ICD-10 codes for deaths and ICD-10-AM codes for hospitalisations as described in Table T7.1, and with details of the percentage of hospitalisations that were the principal diagnosis in Table T7.2 (Technical Appendix 7, page 64). Additional and adjusted multipliers are described below. All estimated incident foodborne GBS and HUS cases were considered hospitalised, so were not modelled. Multipliers were still needed for GBS and HUS to estimate deaths.

Multipliers

Foodborne multiplier

This multiplier adjusts for proportion of illnesses that were acquired from food, and was calculated to estimate hospitalisations and deaths due to sequelae, as it was not necessary to estimate sequelae incidence since antecedent bacterial gastroenteritis cases were already adjusted by a foodborne multiplier. Sequelae can arise from a source other than a bacterial pathogen, from a bacterial pathogen that was not foodborne, or from a foodborne pathogen. Only this latter category was considered a foodborne source. The proportion foodborne multiplier is the simulated product of the bacterial multiplier and the weighted foodborne multiplier and is shown for each sequel in Table T9.1.The approach calculating the proportion foodborne multiplier for each sequel is described as follows:

Table T9.1: Foodborne multipliers for sequelae hospitalisations and deaths estimation

Sequelae Foodborne multiplier

Guillain-Barré syndrome 0.25 (90% CrI: 0.1–0.43)

Haemolytic uraemic syndrome 0.33 (90% CrI: 0.17–0.53)

Irritable bowel syndrome 0.13 (90% CrI: 0.08–0.20)

Reactive arthritis 0.48 (90% CrI: 0.36–0.62)

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Guillain-Barré syndrome

As not all GBS hospitalisations and deaths are from Campylobacter spp., a bacterial multiplier was determined from published studies and multiplied with a foodborne proportion to find the proportion of hospitalisations and deaths from foodborne Campylobacter spp. A systematic review by Poropatich et al.,101 which found that 31% (range 4.8%–72%) of GBS cases arise from Campylobacter spp. for the bacterial multiplier, was used as this was the most recent systematic review. Another systematic review by McGrogan et al.102 reviewed 63 published papers between 1980 and 2009, and estimated that between 6% and 26% of cases of GBS were due to a prior gastrointestinal infection. However the authors did not look at Campylobacter spp. specifically. Applying the bacterial multiplier from Poropatich et al.101 together with the Campylobacter spp. foodborne multiplier described in Technical Appendix 5 (page 56) gave a foodborne multiplier for GBS of 0.25 (90% CrI: 0.11–0.43).

Haemolytic uraemic syndrome

A bacterial multiplier for HUS was first identified from published studies. Table T9.2 presents the percentage of cases of HUS that arise from STEC for four different papers, including a global systematic review. From this, it was assumed that 61% (range 30%–85%) of cases of HUS arise from STEC, modelled as a PERT distribution. Multiplying this bacterial multiplier with the STEC foodborne multiplier described in Technical Appendix 5 (page 56) led to a foodborne multiplier for HUS of 0.33 (90% CrI: 0.18–0.54).

Table T9.2: The percentage of haemolytic uraemic syndrome (HUS) that arise from STEC

Reference Study years Country Study typePercentage of

HUS attributable to STEC

Walker et al.103 1980–2011 Global Systematic review

61% (range 30 – 85%)

Askar et al.104 2011 Germany Surveillance 58%

Elliot et al.105 1994–1998 Australia Surveillance 51%

van de Kar et al.106 1989–1993 The Netherlands Case control 78%

Irritable bowel syndrome

The proportion of cases of IBS that arise from one of Campylobacter spp., non-typhoidal Salmonella spp., or Shigella spp. was estimated based on the proportion of IBS considered to be post-infections in the literature. Table T9.3 presents four papers that estimate this proportion. From this, it was assumed 17% of IBS to be triggered by a gastrointestinal infection, with a range of 7%–33%. This bacterial multiplier was modelled as a PERT distribution. A foodborne multiplier for the combined three pathogens of 73% (90% CrI: 64%–82%) was calculated as a weighted average of the foodborne multipliers for each pathogen, weighted by the total number of IBS cases for each pathogen. Multiplied together, this gave a foodborne multiplier for irritable bowel syndrome of 13% (90% CrI: 8%–20%).

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Table T9.3: The percentage of irritable bowel syndrome (IBS) that arises from Campylobacter spp., non-typhoidal Salmonella spp., or Shigella

ReferencePublication

yearCountry Study type

Number of post

infectious IBS cases/IBS

cases

% of IBS that is post-

infectious

Chaudhary & Truelove107

1962 UK Epidemiological report

34/130 26.2%

Spiller & Garsed108

2009 Global Review - 6%–17%

Haagsma et al.78

2010 The Netherlands

Meta-analysis and estimation

- 17%

Schwille-Kiuntke et al.109

2013 Global Review - 7%–33%

Reactive arthritis

In a review of ReA, Hannu110 compiled population-based studies on the annual incidence of ReA – both from enteric and urogenital infection. Using this compilation, this report calculated the proportion of ReA due to enteric infection by dividing the enteric incidence by the total incidence found in each study (Table T9.4). The midpoint and range of the proportions from these studies was used for the bacterial multiplier. Therefore, it was assumed a median of 66.7% of ReA is due to an enteric infection, with a range of 50%–94.7%. The proportion foodborne was adjusted using a weighted average of the foodborne multipliers for Campylobacter spp., non-typhoidal Salmonella spp., Shigella spp., and Y. enterocolitica, weighted by the total number of ReA cases for each pathogen. This gave a foodborne multiplier of 72% (90% CrI: 60%–82%). Multiplied by the above alternate PERT distribution of median 66.7% (range 50% – 94.7%), gave a foodborne multiplier for reactive arthritis of 48% (90% CrI: 36%–61%).

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Table T9.3: Proportion of reactive arthritis (ReA) attributable to enteric infection, adapted from the table of annual incidence of reactive arthritis based on population studies in Hannu 110

Reference CountryPublication

year

Incidence per 100,000 population

Proportion of ReA due to enteric infection

[enteric/total incidence (%)]Enteric Urogenital Total

Isomaki et al.111

Finland 1978 14 13 27 14/27 (51.9%)

Kvien et al.112

Norway 1994 5 5 10 5/10 (50%)

Savolainen et al.113

Finland 2003 7 3 10 7/10 (70%)

Soderlin et al.114

Sweden 2003 18 1 19 18/19 (94.7%)

Townes115 USA 2010 0.6–3.1 NA NA NA

Hanova et al.116

Czech Republic

2010 6 3 ~9 6/9 (66.7%)

NA – Not applicable

Domestically acquired multiplier

This multiplier adjusts for the proportion of cases that were acquired infection in Australia. The choice of domestically acquire multiplier for each sequel is shown in Table T9.5, with the approach for selecting the multiplier described for each sequelae illness below.

Guillain-Barré syndrome

The domestically acquired multiplier for Campylobacter spp. of 0.97 (range: 0.91–0.99), as described elsewhere was adopted.

Haemolytic uraemic syndrome

Given the relatively small numbers of notified cases of HUS, the domestically acquired multiplier for STEC of 0.99 (range: 0.93–1.0) was adopted. A comparison of available travel data for HUS was in agreement with this assumption.

Irritable bowel syndrome

A combined domestically acquired multiplier for Campylobacter spp., non-typhoidal Salmonella spp., and Shigella of 91% (90% CrI: 88%–94%) was calculated as a weighted average of the domestically acquired multipliers for each pathogen, weighted by the total number of IBS cases for each pathogen.

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Reactive arthritis

A combined domestically acquired multiplier for Campylobacter spp., non-typhoidal Salmonella spp., Shigella, and Y. enterocolitica of 91% (90% CrI: 86%–95%) was calculated as a weighted average of the domestically acquired multipliers for each pathogen, weighted by the total number of ReA cases for each pathogen.

Table T9.5: Domestically acquired multipliers for sequelae hospitalisations and deaths estimation

Sequelae Domestically acquired multiplier

Guillain-Barré syndrome 0.97 (range: 0.91–0.99)

Haemolytic uraemic syndrome 0.99 (range: 0.93–1.0)

Irritable bowel syndrome 0.91 (90% CrI: 0.88–0.94)

Reactive arthritis 0.91 (90% CrI: 0.86–0.95)

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Technical Appendix 10: Comparison with estimates circa 2000Comparison of incidence for foodborne gastroenteritis and key pathogensAs methods and data sources have changed since the circa 2000 estimation effort, incidence estimates were recalculated for total foodborne gastroenteritis and for key pathogens and two sequelae, using the same methods and data sources as were used for the calculation of the circa 2010 estimates. The envelope of foodborne gastroenteritis for 2000 was estimated using the NGSI and the 2010 foodborne proportion of 25%. NNDSS data from 1996 to 2000 and latest pathogen-specific foodborne proportions were used to recalculate estimates for Campylobacter spp., non-typhoidal Salmonella spp., Salmonella Typhi, hepatitis A, L. monocytogenes, GBS, IBS, and Victorian state surveillance data from 1996 to 2000 for the G. lamblia estimate. Incidence rates for 2000 were determined by using the recalculated circa 2000 estimates and population numbers from the ABS from 1996 to 2000.24

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Technical Appendix 11: Pathogen and illness sheets

Adenovirus

Primary data: Water Quality Study Alternate data: IID2

Model input, source & comments Distribution Data for model input

Reported illness: Gastroenteritis multiplier – based on the NGSII

Alternate PERT 2.5%, median, 97.5% values:

0.64, 0.74, 0.84

Pathogen fraction multiplier – based on age adjusted WQS of an estimated four positive isolates per 713 specimens (Hellard et al.2)

Alternate PERT 2.5%, median, 97.5% values:

0.0015, 0.0056, 0.0143

Population adjustment: Australian resident population 2006–2010 June quarter http://www.abs.gov.au/AUSSTATS/[email protected]/DetailsPage/3101.0Dec%202011?OpenDocument (Accessed on 16/8/12)

Empirical By year (2006–2010):

20697880, 21015936, 21384427, 21778845, 22065317

Domestically acquired multiplier: All isolations in the WQS were domestically acquired

N/A

Time trend multiplier: No time trend

N/A

Underreporting: WQS is community surveillance

N/A

Total illness: Population at risk*gastroenteritis multiplier*pathogen fraction multiplier*time trend multiplier

Outcome 5%, medial, 95% values: 28800, 88400, 205000

Rate of total illness per million: circa 2010

Outcome 5%, median, 95% values:

1300, 4150, 9675

Foodborne multiplier: Assumed to be the same as rotavirus

Alternate PERT 5%, median, 95% values:

0.01, 0.02, 0.03

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Model input, source & comments Distribution Data for model input

Total foodborne illness: Total illness*Foodborne multiplier

Outcome 5%, median, 95% values:

500, 1650, 4650

Rate of foodborne illness per million: circa 2010

Outcome 5%, median, 95% values:

25, 80, 215

Astrovirus

Primary data: Water Quality Study Alternate data:

Model input, source & comments Distribution Data for model input

Reported illness:

Gastroenteritis multiplier – based on the NGSII Alternate PERT 2.5%, median, 97.5% values: 0.64, 0.74, 0.84

Pathogen fraction multiplier – based on age adjusted WQS of an estimated four positive isolates of adenovirus per 713 specimens (Hellard et al.2)

Alternate PERT 2.5%, median, 97.5% values:

0.0015, 0.0056, 0.0143

Pathogen comparison multiplier – Kirkwood multiplier67 comparing adenovirus to astrovirus

Constant 0.76

Population adjustment: Australian resident population 2006–2010 June quarter

http://www.abs.gov.au/AUSSTATS/[email protected]/DetailsPage/3101.0Dec%202011?OpenDocument (Accessed on 16/8/12)

Empirical By year (2006–2010): 20697880, 21015936, 21384427, 21778845, 22065317

Domestically acquired multiplier: All isolations in the WQS were domestically acquired

N/A

Time trend multiplier: No time trend

N/A

Underreporting: WQS is community surveillance

N/A

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Model input, source & comments Distribution Data for model input

Total illness: Population at risk*gastroenteritis multiplier*pathogen fraction multiplier*time trend multiplier

Outcome 5%, median, 95% values:

20900, 67100, 15500

Rate of total illness per million: circa 2010

Outcome 5%, median, 95% values:

1000, 3150, 7250

Foodborne multiplier: Assumed to be the same as rotavirus

Alternate PERT 5%, median, 95% values:

0.01, 0.02, 0.03

Total foodborne illness: Total illness*Foodborne multiplier

Outcome 5%, median, 95% values:

350, 1300, 3400

Rate of foodborne illness per million: circa 2010

Outcome 5%, median, 95% values:

20, 60, 160

Bacillus cereus

Primary data: Outbreak Alternate data:

Model input, source & comments Distribution Data for model input

Reported illness: The number of B. cereus outbreak-associated illnesses reported to OzFoodNet 2006–2008.

Empirical By year (2006–2008): 14, 35, 75

Population adjustment: Australian resident population 2006–2010 June quarter

http://www.abs.gov.au/AUSSTATS/[email protected]/DetailsPage/3101.0Dec%202011?OpenDocument (Accessed on 16/8/12)

Empirical By year (2006–2008): 20697880, 21015936, 21384427

Domestically acquired multiplier: Assumed to be 100% domestically acquired due to the short incubation period

PERT Minimum, modal, maximum values: 1, 1 ,1

Underreporting: Outbreak multiplier used to adjust from outbreak to surveillance (O-S)

PERT Minimum, modal, maximum values: 5, 14, 20

Astrovirus (continued)

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Model input, source & comments Distribution Data for model input

Multiplier used to adjust for underreporting from surveillance to community (S-C)

Non-typhoidal Salmonella multiplier adapted from Hall et al.22

Log normal Mean, standard deviation: 7.44, 2.38

Total illness: Outbreak cases*Underreporting(O-S)(S-C)*Proportion travel-related

Outcome 5%, median, 95% values: 900, 3350, 10100

Rate of total illness per million: circa 2010

Outcome 5%, median, 95% values: 40, 150, 485

Foodborne multiplier: Based on 2005 expert elicitation

PERT Minimum, modal, maximum values: 0.98, 1, 1

Total foodborne illness: Total illness*Foodborne multiplier

Outcome 5%, median, 95% values: 900, 3350, 10100

Rate of foodborne illness per million: circa 2010

Outcome 5%, median, 95% values: 40, 150, 485

Campylobacter spp.

Primary data: NNDSS Alternate data: Water Quality Study

Model input, source & comments Distribution Data for model input

Reported illness: NNDSS data Available from: http://www9.health.gov.au/cda/source/rpt_4.cfm (Accessed on 12/11/13)

Empirical By year (1996–2000): 12169, 11984, 12647, 12373, 13676

(2006–2010): 15416, 16980, 15539, 16075, 16967

Bacillus cereus (continued)

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Model input, source & comments Distribution Data for model input

Population adjustment: Australian resident population 2006–2010 June quarter http://www.abs.gov.au/AUSSTATS/[email protected]/DetailsPage/3101.0Dec%202011?OpenDocument (Accessed on 16/8/12)

Empirical By year (1996–2000): 18310714, 18517564, 18711271, 18925855, 19153380

(2006–2010): 20697880, 21015936, 21384427, 21778845, 22065317 1.5

Correction factor: Hall et al.22 NSW Population - June quarter By year (1996–2000 & 2006–2010): 6176461, 6246267, 6305799, 6375103, 6446558 & 6816087, 6885204, 6975891, 7069707, 7144928 1/(1-NSW Pop/AUS Pop)

Constant

Domestically acquired multiplier: NNDSS travel data

PERT Minimum, modal, maximum values: 0.91, 0.97, 0.99

Underreporting:

Multiplier used to adjust for underreporting from surveillance to community (S-C) Campylobacter spp. multiplier adapted from Hall et al.22

Log normal Mean, standard deviation: 10.45, 2.98

Total illness: Reported cases (NNDSS)*correction factor*travel adjustment* underreporting(S-C)

Outcome 5%, median, 95% values: 147000, 234000, 374000

Rate of total illness per million: circa 2010

Outcome 5%, median, 95% values: 6850, 10950, 17415

Foodborne multiplier: Expert elicitation study 2009

Alternate PERT 5%, median, 95% values: 0.62, 0.77, 0.89

Rate of foodborne illness per million: circa 2010 and circa 2000

Outcome 5%, median, 9% values: 5050, 8400, 13650 (circa 2010) 4500, 7400, 12200 (circa 2000)

Campylobacter spp. (continued)

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Ciguatera

Primary data: Queensland notifications Alternate data: Outbreak

Model input, source & comments Distribution Data for model input

Reported illness: The number of ciguatera notifications reported in Queensland in OzFoodNet Queensland Annual Reports 2006–2010

Empirical By year (2006–2010): 26, 18, 14, 7, 30

Population adjustment: Australian resident population 2006–2010 June quarter http://www.abs.gov.au/AUSSTATS/[email protected]/DetailsPage/3101.0Dec%202011?OpenDocument (Accessed on 16/8/12)

Empirical By year (2006–2010): 20697880, 21015936, 21384427, 21778845, 22065317

Correction factor: Qld Population and NT population Australian population/Qld and NT population

Empirical 1.05

Domestically acquired multiplier: Assumed to be 100% domestically acquired

PERT 1.05

Domestically acquired multiplier: Assumed to be 100% domestically acquired

PERT Minimum, modal, maximum values: 1, 1 ,1

Underreporting:

Multiplier used to adjust for underreporting from surveillance to community (S-C)

Non-typhoidal Salmonella multiplier adapted from Hall et al.22

Log Normal Mean, standard deviation: 7.44, 2.38

Total illness: Reported cases (Qld notifications)*Population adjustment*Underreporting(O-S)(S-C)*Proportion travel-related

Outcome 5%, median, 95% values: 40, 150, 300

Rate of total illness per million: circa 2010

Outcome 5%, median, 95% values: 2, 7, 14

Foodborne multiplier: Assumed to be 100% foodborne

PERT Minimum, modal, maximum values: 1, 1, 1

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Model input, source & comments Distribution Data for model input

Total foodborne illness: Total illness*Foodborne multiplier

Outcome 5%, median, 95% values: 40, 150, 300

Rate of foodborne illness per million: circa 2010

Outcome 5%, median, 95% values: 2, 7, 14

Clostridium perfringens

Primary data: Outbreak Alternate data: Water Quality Study

Model input, source & comments Distribution Data for model input

Reported illness: The number of C. perfringens outbreak-associated illnesses reported to OzFoodNet 2006–2008.

Empirical By year (2006–2008): 183, 44, 383

Population adjustment:

Australian resident population 2006–2010 June quarter http://www.abs.gov.au/AUSSTATS/[email protected]/DetailsPage/3101.0Dec%202011?OpenDocument (Accessed on 16/8/12)

Empirical By year (2006–2008): 20697880, 21015936, 21384427

Domestically acquired multiplier: Assumed to be 100% domestically acquired due to the short incubation period

PERT Minimum, modal, maximum values: 1, 1, 1

Underreporting:

Outbreak multiplier used to adjust from outbreak to surveillance (O-S)

PERT Minimum, modal, maximum values: 5, 14, 20

Multiplier used to adjust for underreporting from surveillance to community (S-C) Non-typhoidal Salmonella multiplier adapted from Hall et al. 22

Log normal Mean, standard deviation: 7.44, 2.38

Total illness: Outbreak cases*Underreporting(O-S)(S-C)*Proportion travel-related

Outcome 5%, median, 95% values: 2600, 16500, 53400

Ciguatera (continued)

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Model input, source & comments Distribution Data for model input

Rate of total illness per million: circa 2010

Outcome 5%, median, 95% values: 135, 785, 2465

Foodborne multiplier: Expert elicitation study 2009

PERT Minimum, modal, maximum values: 0.86, 0.98, 1

Total foodborne illness: Total illness*Foodborne multiplier

Outcome 5%, median, 95% values: 2550, 16100, 50600

Rate of foodborne illness per million: circa 2010

Outcome 5%, median, 95% values: 130, 765, 2350

Cryptosporidium spp.

Primary data: NNDSS Alternate data: Water Quality Study

Model input, source & comments Distribution Data for model input

Reported illness: NNDSS data Available from: http://www9.health.gov.au/cda/source/rpt_4.cfm (Accessed on 28/06/12)

Empirical By year (2006–2010): 3201, 2809, 2004, 4624, 1479

Population adjustment: Australian resident population 2006–2010 June quarter http://www.abs.gov.au/AUSSTATS/[email protected]/DetailsPage/3101.0Dec%202011?OpenDocument (Accessed on 16/8/12)

Empirical By year (2006–2010): 20697880, 21015936, 21384427, 21778845, 22065317

Domestically acquired multiplier: NNDSS travel data

PERT Minimum, modal, maximum values: 0.92, 0.97, 0.99

Underreporting:

Multiplier used to adjust for underreporting from surveillance to community (S-C) Non-typhoidal Salmonella multiplier adapted from Hall et al.22

Log normal Mean, standard deviation: 7.44, 2.38

Clostridium perfringens (continued)

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Model input, source & comments Distribution Data for model input

Total illness:Reported cases (NNDSS)*travel adjustment*underreporting(S-C)

Outcome 5%, medial, 95% values:8150, 17900, 39800

Rate of total illness per million: circa 2010

Outcome 5%, median, 95% values:365, 850, 1860

Foodborne multiplier: Based on 2005 Delphi survey

Alternate PERT 5%, median, 95% values:0.01, 0.1, 0.27

Total foodborne illness: Total illness*Foodborne multiplier

Outcome 5%, median, 95% values:150, 1700, 6100

Rate of foodborne illness per million: circa 2010

Outcome 5%, median, 95% values:7, 80, 320

Giardia lamblia

Primary data: Victoria notifications Alternate data: Water Quality Study

Model input, source & comments Distribution Data for model input

Reported illness: Victorian state notifications from: O’Grady and Tallis;117 Brown et al.61-64

Giardiasis became a non-notifiable disease in Victoria in 2010

Empirical By year (1996–2000): 1085, 1060, 999, 921, 866

(2006–2009): 1192, 1382, 1434, 1433

Population adjustment: Australian resident population 2006–2010 June quarter http://www.abs.gov.au/AUSSTATS/[email protected]/DetailsPage/3101.0Dec%202011?OpenDocument (Accessed on 16/8/12)

Empirical By year

(1996–2000):

18310714, 18517564, 18711271, 18925855, 19153380

(2006–2009):

20697880, 21015936, 21384427, 21778845

4.03

Cryptosporidium spp. (continued)

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Model input, source & comments Distribution Data for model input

Correction factor: Victorian population - June quarter By year (1996–2000 & 2006–2009): 4534984, 4569297, 4606970, 4652462, 4704065& 5126540, 5204607, 5293088, 5395137 Australian population/Victorian population

Constant

Domestically acquired multiplier: Victorian notification data

PERT Minimum, modal, maximum values: 0.84, 0.85, 0.89

Underreporting:

Multiplier used to adjust for underreporting from surveillance to community (S-C) Non-typhoidal Salmonella multiplier adapted from Hall et al.22

Log Normal Mean, standard deviation: 7.44, 2.38

Total illness: Reported cases (Victorian notifications)* correction factor*travel adjustment*underreporting(S-C)

Outcome 5%, median, 95% values: 19800, 32800, 56400

Rate of total illness per million: circa 2010

Outcome 5%, median, 95% values: 920, 1560, 2665

Foodborne multiplier: Based on Delphi 2005

PERT Minimum, modal, maximum values: 0.01, 0.06, 0.5

Total foodborne illness: Total illness*Foodborne multiplier

Outcome 5%, median, 95% values: 800, 3700, 10600 (circa 2010) 565, 2600, 7400 (circa 2000)

Rate of foodborne illness per million: circa 2010

Outcome 5%, median, 95% values: 35, 175, 490 (circa 2010) 30, 140, 405 (circa 2000)

Giardia lamblia (continued)

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Guillain-Barré syndrome (GBS)

Primary data: NNDSS and literature Alternate data: Hospitalisations and literature

Model input, source & comments Distribution Data for model input

Reported illness: As GBS is not notified, sequelae multiplier, or the proportion of foodborne Campylobacter spp. cases that develop GBS, was used to determine the number of foodborne GBS cases. This proportion was a midpoint between estimates from the literature reported in McCarthy and Giesecke,71 Tam et al.,70 and Allos.72 See Technical Appendix 8 for further explanation.

Antecedent bacterial gastroenteritis cases: estimated number of foodborne Campylobacter spp. cases.

Outcome 5%, median, 95% values: 108500, 179000, 290000 (circa 2010)

82500, 13900, 227000 (circa 2000)

Sequelae multiplier PERT Minimum, modal, maximum values: 0.000192, 0.00034, 0.000945

Total foodborne illness: Foodborne Campylobacter spp. cases*Proportion of cases that develop GBS

Outcome 5%, median, 95% values: 30, 75, 150 (circa 2010) 25, 50, 100 (circa 2000)

Rate of foodborne illness from Campylobacter spp. per million: circa 2010 and circa 2000

Outcome 5%, median, 95% values: 2, 3.1, 6 (circa 2010) 1, 2.8, 6 (circa 2000)

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Haemolytic uraemic syndrome (HUS)Primary data: South Australian STEC surveillance and literature

Alternate data: Hospitalisations

Model input, source & comments Distribution Data for model input

Reported illness: As HUS is a sequel to STEC, the proportion of foodborne STEC cases that develop HUS was used to determine the number of foodborne HUS cases. This proportion (sequelae multiplier) is from Vally et al.77 See Technical Appendix 8 for further explanation.

Antecedent bacterial gastroenteritis cases: estimated number of foodborne STEC cases

Outcome 5%, median, 95% values: 950, 2350, 5850 (circa 2010) 550, 1900, 5000 (circa 2010)

Sequelae multiplier PERT Minimum, modal, maximum values: 0.017, 0.03, 0.051

Total foodborne illness: Foodborne STEC cases*Proportion of cases that develop HUS

Outcome 5%, median, 95% values: 25, 70, 200

Rate of foodborne illness from STEC per million: circa 2010

Outcome 5%, median, 95% values: 1, 3.3, 9

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Hepatitis A

Primary data: NNDSS Alternate data:

Model input, source & comments Distribution Data for model input

Reported illness: NNDSS data Available from: http://www9.health.gov.au/cda/source/rpt_4.cfm (Accessed on 15/05/12)

Empirical By year (1996–2000): 2058, 3032, 2466, 1551, 809

(2006–2010): 281, 166, 277, 564, 267

Population adjustment: Australian resident population 2006–2010 June quarter http://www.abs.gov.au/AUSSTATS/[email protected]/DetailsPage/3101.0Dec%202011?OpenDocument (Accessed on 16/8/12)

Empirical By year (1996–2000): 18310714, 18517564, 18711271, 18925855, 19153380

(2006–2010): 20697880, 21015936, 21384427, 21778845, 22065317

Domestically acquired multiplier: NNDSS travel data

PERT Minimum, modal, maximum values: 0.42, 0.58, 0.77

Underreporting:

Multiplier used to adjust for underreporting from surveillance to community (S-C)

Alternate PERT 2.5%, median, 97.5% values: 1, 2, 3

Total illness: Reported cases (NNDSS)*travel adjustment*underreporting (S-C)

Alternate PERT 2.5%, median, 97.5% values: 1, 2, 3

Rate of total illness per million: circa 2010

Outcome 5%, median, 95% values: 7, 15, 35

Foodborne multiplier: Expert elicitation study 2009

Alternate PERT 5%, median, 95% values: 0.05, 0.12, 0.24

Total foodborne illness: Total illness*Foodborne multiplier

Outcome 5%, median, 95% values: 10, 40, 100 (circa 2010) 65, 245, 725 (circa 2000)

Rate of foodborne illness per million: circa 2010 and circa 2000

Outcome 5%, median, 95% values: 1, 2, 5 (circa 2010) 3, 13, 40 (circa 2000)

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Irritable bowel syndrome (IBS)

Primary data: NNDSS and Literature Alternate data: Literature

Model input, source & comments Distribution Data for model input

Reported illness: As IBS is not notified, the proportion of foodborne Campylobacter spp., Salmonella spp., and Shigella cases that develop IBS was calculated to determine the number of foodborne IBS cases. See Technical Appendix 8 for further explanation

Antecedent bacterial gastroenteritis cases: Estimated number of foodborne Campylobacter spp. cases

Outcome 5%, median, 95% values 108500, 179000, 290000 (circa 2010) 82500, 139000, 227000 (circa 2000)

Estimated number of foodborne non-typhoidal Salmonella spp. cases

Outcome 5%, median, 95% values 21200, 39600, 73400 (circa 2010) 15000, 28000, 50000 (circa 2000)

Estimated number of foodborne Shigella spp. cases

Outcome 5%, median, 95% values 150, 350, 850 (circa 2010) 175, 515, 1300 (circa 2000)

Sequelae multiplier Alternate PERT 2.5%, median, 97.5% values: 0.072, 0.088, 0.104

Total foodborne illness: Foodborne bacterial gastroenteritis cases from 3 pathogens*Proportion of these cases that develop IBS

Outcome 2.5%, median, 97.5% values: 12500, 19500, 30700 (circa 2010) 9500, 14800, 23500 (circa 2000)

Rate of foodborne illness per million: circa 2010

Outcome 2.5%, median, 97.5% values: 570, 915, 1440 (circa 2010) 550, 850, 1350 (circa 2000)

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Listeria monocytogenes

Primary data: NNDSS Alternate data: Outbreak

Model input, source & comments Distribution Data for model input

Reported illness: NNDSS data Available from: http://www9.health.gov.au/cda/source/rpt_4.cfm (Accessed on 12/11/13)

Empirical By year (1996–2000): 66, 74, 53, 63, 67

(2006–2010): 61, 50, 68, 92, 71

Population adjustment: Australian resident population 2006–2010 June quarter http://www.abs.gov.au/AUSSTATS/[email protected]/DetailsPage/3101.0Dec%202011?OpenDocument (Accessed on 16/8/12)

Empirical By year (1996–2000): 18310714, 18517564, 18711271, 18925855, 19153380

(2006–2010): 20697880, 21015936, 21384427, 21778845, 22065317

Domestically acquired multiplier: Assumed to be 100% as the majority of travellers are not at high risk

PERT Minimum, modal, maximum values: 1, 1, 1

Underreporting:

Multiplier used to adjust for underreporting from surveillance to community (S-C)

Alternate PERT 2.5%, medial, 97.5% values: 1, 2, 3

Total illness: Reported cases (NNDSS)*travel adjustment*underreporting (S-C)

Outcome 5%, median, 95% values:

50, 150, 200

Rate of total illness per million: circa 2010

Outcome 5%, median, 95% values: 3, 7, 75

Foodborne multiplier: Expert elicitation study 2009

PERT Minimum, modal, maximum values: 0.9, 0.98, 1

Total foodborne illness: Total illness*Foodborne multiplier

Outcome 5%, median, 95% values: 50, 150, 200 (circa 2010) 70, 125, 185 (circa 2000)

Rate of foodborne illness per million: circa 2010

Outcome 5%, median, 95% values: 3, 7, 75 (circa 2010) 4, 7, 10 (circa 2000)

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Norovirus

Primary data: Water Quality Study Alternate data: Outbreak

Model input, source & comments Distribution Data for model input

Reported illness: Gastroenteritis multiplier – based on the NGSII

Alternate PERT 2.5%, median, 97.5% values: 0.64, 0.74, 0.84

Pathogen fraction multiplier – based on age adjusted WQS of an estimated 69 positive isolates per 703 specimens (Sinclair et al.20)

Alternate PERT 2.5%, median, 97.5% values: 0.0772, 0.0982, 0.1226

Population adjustment: Australian resident population 2006–2010 June quarter http://www.abs.gov.au/AUSSTATS/[email protected]/DetailsPage/3101.0Dec%202011?OpenDocument (Accessed on 16/8/12)

Empirical By year (2006–2010): 20697880, 21015936, 21384427, 21778845, 22065317

Domestically acquired multiplier: All isolations in the WQS were domestically acquired

N/A

Time trend multiplier: No time trend

N/A

Underreporting: WQS is community surveillance

N/A

Total illness: Population at risk*gastroenteritis multiplier*pathogen fraction multiplier*time trend multiplier

Outcome 5%, median, 95% values: 1220000, 1550000, 1940000

Rate of total illness per million: circa 2010

Outcome 5%, median, 95% values: 57100, 72500, 90550

Foodborne multiplier: Expert elicitation study 2009

Alternate PERT 5%, median, 95% values: 0.05, 0.18, 0.35

Total foodborne illness: Total illness*Foodborne multiplier

Outcome 5%, median, 95% values: 78100, 276000, 563000

Rate of foodborne illness per million: circa 2010

Outcome 5%, median, 95% values: 3620, 12920, 26300

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Other pathogenic Escherichia coli

Primary data: Water Quality Study Alternate data: IID2

Model input, source & comments Distribution Data for model input

Reported illness: Gastroenteritis multiplier – based on the NGSII

Alternate PERT 2.5%, median, 97.5% values: 0.64, 0.74, 0.84

Pathogen fraction multiplier – based on age adjusted WQS of an estimated 50 positive isolates per 713 specimens (Hellard et al.2)

Alternate PERT 2.5%, median, 97.5% values: 0.0525, 0.074, 0.0914

Population adjustment:

Australian resident population 2006–2010 June quarter http://www.abs.gov.au/AUSSTATS/[email protected]/DetailsPage/3101.0Dec%202011?OpenDocument (Accessed on 16/8/12)

Empirical By year (2006–2010): 20697880, 21015936, 21384427, 21778845, 22065317

Domestically acquired multiplier: All isolations in the WQS were domestically acquired

Empirical N/A

Time trend multiplier: No time trend

N/A

Underreporting: WQS is community surveillance

N/A

Total illness: Population at risk*gastroenteritis multiplier*pathogen fraction multiplier*time trend multiplier

Outcome 5%, median, 95% values: 833000, 1100000, 1450000

Rate of total illness per million: circa 2010

Outcome 5%, median, 95% values: 39150, 51350, 67550

Foodborne multiplier: Expert elicitation study 2009

Alternate PERT 5%, median, 95% values: 0.08, 0.23, 0.55

Total foodborne illness: Total illness*Foodborne multiplier

Outcome 5%, median, 95% values: 85800, 255000, 632000

Rate of foodborne illness per million: circa 2010

Outcome 5%, median, 95% values: 4100, 11600, 29700

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Reactive arthritis (ReA)

Primary data: NNDSS and literature Alternate data:

Model input, source & comments Distribution Data for model input

Reported illness: As ReA is not notified, the proportion of foodborne Campylobacter spp., Salmonella spp., Shigella, and Y. enterocolitica cases that develop ReA was calculated to determine the number of foodborne ReA cases. The proportion for each of the four pathogens was calculated from the literature. See Technical Appendix 8 for further explanation

Antecedent bacterial gastroenteritis cases: Estimated number of foodborne Campylobacter spp. cases

Outcome 5%, median, 95% values: 108500, 179000, 290000 (circa 2010) 82500, 139000, 227000 (circa 2000)

Estimated number of foodborne non-typhoidal Salmonella spp. cases

Outcome 5%, median, 95% values: 21200, 39600, 73400 (circa 2010) 15000, 28000, 50000 (circa 2000)

Estimated number of foodborne Shigella spp. cases

Outcome 5%, median, 95% values: 150, 350, 850 (circa 2010) 175, 515, 1300 (circa 2000)

Estimated number of foodborne Yersinia enterocolitica cases

Outcome 5%, median, 95% values: 650, 1150, 1950 (circa 2010) 300, 800, 1650 (circa 2000)

Sequelae multiplier for Campylobacter spp. Alternate PERT Minimum, medial, maximum values: 0.028, 0.07, 0.16

Sequelae multiplier for non-typhoidal Salmonella spp.

Alternate PERT Minimum, medial, maximum values: 0, 0.085, 0.26

Sequelae multiplier for Shigella spp. PERT Minimum, modal, maximum values: 0.012, 0.097, 0.098

Sequelae multiplier for Yersinia enterocolitica Alternate PERT Minimum, medial, maximum values: 0, 0.12, 0.231

Total foodborne illness: Foodborne bacterial gastroenteritis cases from pathogens*Proportion of cases that develop ReA

Outcome 5%, median, 95% values: 8750, 16200, 30400

Rate of foodborne illness per million: circa 2010

Outcome 5%, median, 95% values: 415, 765, 1375

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Rotavirus

Primary data: Water Quality Study Alternate data: IID2

Model input, source & comments Distribution Data for model input

Reported illness:

Gastroenteritis multiplier – based on the NGSII Alternate PERT 2.5%, median, 97.5% values: 0.64, 0.74, 0.84

Pathogen fraction multiplier – based on age adjusted WQS of an estimated 6 positive isolates per 713 specimens (Hellard et al.2)

Alternate PERT 2.5%, median, 97.5% values: 0.0031, 0.0084, 0.0182

Population adjustment: Australian resident population 2006–2010 June quarter http://www.abs.gov.au/AUSSTATS/[email protected]/DetailsPage/3101.0Dec%202011?OpenDocument (Accessed on 16/8/12)

Empirical By year (2006–2010): 20697880, 21015936, 21384427, 21778845, 22065317

Domestically acquired multiplier: All isolations in the WQS were domestically acquired

N/A

Time trend multiplier: Based on Dey et al.36

Alternate PERT 2.5%, median, 97.5% values: 0.318, 0.338, 0.359

Underreporting: WQS is community surveillance

N/A

Total illness: Population at risk*gastroenteritis multiplier*pathogen fraction multiplier*time trend multiplier

Outcome 5%, median, 95% values: 18500, 44800, 90800

Rate of total illness per million: circa 2010

Outcome 5%, median, 95% values: 875, 2100, 4260

Foodborne multiplier: Expert elicitation study 2009

Alternate PERT 5%, median, 95% values: 0.01, 0.02, 0.03

Total foodborne illness: Total illness*Foodborne multiplier

Outcome 5%, median, 95% values: 300, 850, 2000

Rate of foodborne illness per million: circa 2010

Outcome 5%, median, 95% values: 15, 40, 95

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Salmonella spp., non-Typhoidal

Primary data: NNDSS Alternate data: Water Quality Study

Model input, source & comments Distribution Data for model input

Reported illness: NNDSS data Available from: http://www9.health.gov.au/cda/source/rpt_4.cfm (Accessed on 11/12/13)

Empirical By year (1996–2000) 5744, 6955, 7513, 7008, 6187

(2006–2010) 8241, 9502, 8316, 9524, 11928

Population adjustment: Australian resident population 2006–2010 June quarter http://www.abs.gov.au/AUSSTATS/[email protected]/DetailsPage/3101.0Dec%202011?OpenDocument (Accessed on 16/8/12)

Empirical By year (1996–2000): 18310714, 18517564, 18711271, 18925855, 19153380

(2006–2010): 20697880, 21015936, 21384427, 21778845, 22065317

Domestically acquired multiplier: NNDSS travel data

PERT Minimum, modal, maximum values: 0.7, 0.85, 0.95

Underreporting:

Multiplier used to adjust for underreporting from surveillance to community (S-C) Non-typhoidal Salmonella multiplier adapted from Hall et al. 22

Log normal Mean, standard deviation: 7.44, 2.38

Total illness: Reported cases (NNDSS)*travel adjustment*underreporting(S-C)

Outcome 5%, median, 95% values: 31900, 56200, 101000

Foodborne multiplier: Expert elicitation study 2009

Alternate PERT 5%, median, 95% values: 0.53, 0.72, 0.86

Total foodborne illness: Total illness*Foodborne multiplier

Outcome 5%, median, 95% values: 21200, 39600, 73400 (circa 2010) 15000, 28000, 50000 (circa 2000)

Rate of foodborne illness per million: circa 2010 and circa 2000

Outcome 5%, median, 95% values: 1000, 1850, 3350 (circa 2010) 800, 1500, 2700 (circa 2000)

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Salmonella Typhi

Primary data: NNDSS Alternate data:

Model input, source & comments Distribution Data for model input

Reported illness: NNDSS data Available from: http://www9.health.gov.au/cda/source/rpt_4.cfm (Accessed on 28/06/12)

Empirical By year (1996–2000): 72, 72, 57, 63, 58

(2006–2010): 77, 90, 105, 115, 95

Population adjustment: Australian resident population 2006–2010 June quarter http://www.abs.gov.au/AUSSTATS/[email protected]/DetailsPage/3101.0Dec%202011?OpenDocument (Accessed on 16/8/12)

Empirical By year (1996–2000): 18310714, 18517564, 18711271, 18925855, 19153380

(2006–2010): 20697880, 21015936, 21384427, 21778845, 22065317

Domestically acquired multiplier: NNDSS travel data

PERT 5%, median, 95% values: 0, 1, 2

Underreporting:

Multiplier used to adjust for underreporting from surveillance to community (S-C) Multiplier of two for serious illnesses

Alternate PERT 2.5%, median, 97.5% values: 1, 2, 3

Total illness circa 2010: Reported cases (NNDSS)*travel adjustment*underreporting(S-C)

Outcome 5%, median, 95% values: 8, 20, 45

Rate of total illness per million: circa 2010

Outcome Minimum, modal, maximum values: 0.02, 0.75, 0.97

Foodborne multiplier: Based on Delphi 2005

PERT Minimum, modal, maximum values: 0.02, 0.75, 0.97

Total foodborne illness: Total illness*Foodborne multiplier

Outcome 5%, median, 95% values: 5, 15, 30 (circa 2010) 3, 9, 21 (circa 2000)

Rate of foodborne illness per million: circa 2010 and circa 2000

Outcome 5%, median, 95% values: 0, 0.6, 1 (circa 2010) 0, 0.5, 1 (circa 2000)

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Sapovirus

Primary data: Water Quality Study Alternate data: IID2

Model input, source & comments Distribution Data for model input

Reported illness: Gastroenteritis multiplier – based on the NGSII

Alternate PERT 2.5%, median, 97.5% values: 0.64, 0.74, 0.84

Pathogen fraction multiplier – based on age adjusted WQS findings for norovirus of an estimated 69 isolates per 703 specimens (Sinclair et al.20)

Alternate PERT 2.5%, median, 97.5% values: 0.0772, 0.0982, 0.1226

Pathogen comparison multiplier – Kirkwood multiplier67 comparing norovirus to sapovirus

Constant 0.5

Population adjustment: Australian resident population 2006–2010 June quarter http://www.abs.gov.au/AUSSTATS/[email protected]/DetailsPage/3101.0Dec%202011?OpenDocument (Accessed on 16/8/12)

Empirical By year (2006–2010): 20697880, 21015936, 21384427, 21778845, 22065317

Domestically acquired multiplier: All isolations in the WQS were domestically acquired

N/A

Time trend multiplier: No time trend

N/A

Underreporting: WQS is community surveillance

N/A

Total illness: Population at risk*gastroenteritis multiplier*pathogen fraction multiplier*pathogen comparison multiplier*time trend multiplier

Outcome 5%, medial, 95% values: 63400, 81600, 102000

Rate of total illness per million: circa 2010

Outcome 5%, median, 95% values: 3000, 3800, 4800

Foodborne multiplier: Assumed to be the same as norovirus

PERT Minimum, modal, maximum values: 0.05, 0.18, 0.35

Total foodborne illness: Total illness*Foodborne multiplier

Outcome 5%, median, 95% values: 7450, 15000, 24300

Rate of foodborne illness per million: circa 2010

Outcome 5%, median, 95% values: 350, 700, 1150

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Scombrotoxicosis

Primary data: Outbreak Alternate data:

Model input, source & comments Distribution Data for model input

Reported illness: The number of scombrotoxicosis outbreak-associated illnesses reported to OzFoodNet 2006–2008.

Empirical By year (2006–2008) 12, 17, 0

Population adjustment:

Australian resident population 2006–2010 June quarter http://www.abs.gov.au/AUSSTATS/[email protected]/DetailsPage/3101.0Dec%202011?OpenDocument (Accessed on 16/8/12)

Empirical By year (2006–2008):

20697880, 21015936, 21384427

Domestically acquired multiplier: Assumed to be 100% domestically acquired due to the short incubation period.

PERT Minimum, modal, maximum values: 1, 1 ,1

Underreporting:

Outbreak multiplier used to adjust from outbreak to surveillance (O-S)

PERT Minimum, modal, maximum values: 5, 14, 20

Multiplier used to adjust for underreporting from surveillance to community (S-C) Non-typhoidal Salmonella multiplier adapted from Hall et al.22

Log Normal Mean, standard deviation: 7.44, 2.38

Total illness: Outbreak cases*Underreporting(O-S)(S-C)*Proportion travel-related

Outcome 5%, median, 95% values: 0, 1050, 2450

Rate of total illness per million: circa 2010

Outcome 5%, median, 95% values: 0, 50, 115

Foodborne multiplier: Assumed to be 100% foodborne

PERT Minimum, modal, maximum values: 1, 1, 1

Total foodborne illness: Total illness*Foodborne multiplier

Outcome 5%, median, 95% values: 0, 1050, 2450

Rate of foodborne illness per million: circa 2010

Outcome 5%, median, 95% values: 0, 50, 115

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Shigella

Primary data: NNDSS Alternate data:

Model input, source & comments Distribution Data for model input

Reported illness: NNDSS data Available from: http://www9.health.gov.au/cda/source/rpt_4.cfm (Accessed on 12/11/13)

Empirical By year (1996–2000): 660, 802, 580, 534, 488

(2006–2010): 545, 597, 828, 618, 550

Population adjustment: Australian resident population 2006–2010 June quarter http://www.abs.gov.au/AUSSTATS/[email protected]/DetailsPage/3101.0Dec%202011?OpenDocument (Accessed on 16/8/12)

Empirical By year (1996–2000): 18310714, 18517564, 18711271, 18925855, 19153380

(2006–2010): 20697880, 21015936, 21384427, 21778845, 22065317

Domestically acquired multiplier: NNDSS travel data

PERT Minimum, modal, maximum values: 0.45, 0.7, 0.84

Underreporting:

Multiplier used to adjust for underreporting from surveillance to community (S-C) Non-typhoidal Salmonella multiplier adapted from Hall et al.22

Log normal Mean, standard deviation: 7.44, 2.38

Total illness circa 2010: Reported cases (NNDSS)*travel adjustment*underreporting(S-C)

Outcome 5%, median, 95% values: 1650, 3000, 5400

Rate of total illness per million: circa 2010

Outcome 5%, median, 95% values: 75, 140, 260

Foodborne multiplier: Expert elicitation study 2009

Alternate PERT 5%, median, 95% values: 0.05, 0.12, 0.23

Total foodborne illness: Total illness*Foodborne multiplier

Outcome 5%, median, 95% values: 150, 350, 850 (circa 2010) 175, 515, 1300 (circa 2000)

Rate of foodborne illness per million: circa 2010 and circa 2000

Outcome 5%, median, 95% values: 6, 16, 40 (circa 2010) 9, 28, 70 (circa 2000)

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Staphylococcus aureus

Primary data: Outbreak Alternate data:

Model input, source & comments Distribution Data for model input

Reported illness: The number of S. aureus outbreak-associated illnesses reported to OzFoodNet 2006–2008.

Empirical By year (2006–2008) 3, 14, 50

Population adjustment:

Australian resident population 2006–2008 June quarter http://www.abs.gov.au/AUSSTATS/[email protected]/DetailsPage/3101.0Dec%202011?OpenDocument (Accessed on 16/8/12)

Empirical By year (2006–2008): 20697880, 21015936, 21384427

Domestically acquired multiplier: Assumed to be 100% domestically acquired due to short incubation period

PERT Minimum, modal, maximum values: 1, 1, 1

Underreporting:

Outbreak multiplier used to adjust from outbreak to surveillance (O-S)

PERT Minimum, modal, maximum values: 5, 14, 20

Multiplier used to adjust for underreporting from surveillance to community (S-C) Non-typhoidal Salmonella multiplier adapted from Hall et al. 22

Log normal Mean, standard deviation: 7.44, 2.38

Total illness: Outbreak cases*Underreporting (O-S)(S-C)*Proportion travel-related

Outcome 5%, median, 95% values: 200, 1300, 7050

Rate of total illness per million: circa 2010

Outcome 5%, median, 95% values: 9, 60, 350

Foodborne multiplier: Based on Delphi 2005

PERT Minimum, modal, maximum values: 0.95, 1, 1

Total foodborne illness: Total illness*Foodborne multiplier

Outcome 5%, median, 95% values: 200, 1300, 7000

Rate of foodborne illness per million: circa 2010

Outcome 5%, median, 95% values: 9, 60, 350

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Shiga toxin-producing Escherichia coli

Primary data: South Australia surveillance Alternate data: NNDSS

Model input, source & comments Distribution Data for model input

Reported illness: South Australian state STEC surveillance from the study by Vally et al.77

Empirical By year (2006–2010) 35, 40, 39, 62, 32

Population adjustment: Australian resident population 2006–2010 June quarter

http://www.abs.gov.au/AUSSTATS/[email protected]/DetailsPage/3101.0Dec%202011?OpenDocument (Accessed on 16/8/12)

Empirical By year (2006–2010):

20697880, 21015936, 21384427, 21778845, 22065317

Correction factor: SA population - June quarter By year (2006–2010): 1567888, 1582559, 1597343, 1614375, 1629434 Australian population/SA population

13.4

Domestically acquired multiplier: NNDSS travel data

PERT Minimum, modal, maximum values: 0.93, 0.99, 1

Underreporting:

Multiplier used to adjust for underreporting from surveillance to community (S-C) STEC multiplier adapted from Hall et al.22

Log normal Mean, standard deviation: 8.83, 3.7

Total illness: Reported cases (SA surveillance)*correction factor*travel adjustment*underreporting(S-C)

Outcome 5%, median, 95% values: 2050, 4300, 9500

Rate of total illness per million: circa 2010

Outcome 5%, median, 95% values: 100, 200, 450

Foodborne multiplier: Expert elicitation study 2009

Alternate PERT 5%, median, 95% values: 0.32, 0.56, 0.83

Foodborne multiplier: Expert elicitation study 2009

Outcome 5%, median, 95% values: 950, 2350, 5850

Rate of foodborne illness per million: circa 2010

Outcome 5%, median, 95% values: 45, 110, 260

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Toxoplasma gondii

Primary data: Seroprevalence estimate Alternate data: NNDSS

Model input, source & comments Distribution Data for model input

Reported illness:USA seroprevalence data21 extrapolated to the Australian population for 2010 by age group

Empirical 0–4: 57095–9: 574910–19: 1074420–29: 1172830–39: 1080940–49: 1037750–59: 890360–69: 652170–79: 371380+: 2342

Total: 76095

Population adjustment:Australian resident population 2010 June quarter by age grouphttp://www.abs.gov.au/AUSSTATS/[email protected]/DetailsPage/3101.0Dec%202011?OpenDocument (Accessed on 16/8/12)

Empirical 0–4: 14416795–9: 135221110–19: 285205020–29: 324034730–39: 310822440–49: 310587750–59: 277351160–69: 211415870–79: 125311480+: 824146

Domestically acquired multiplier:Assumed to be 100% domestically acquired

PERT Minimum, modal, maximum values: 1, 1, 1

Proportion symptomatic:Scallan et al.6 and Abelson et al.4

PERT Minimum, modal, maximum values: 0.11, 0.15, 0.21

Total illness:Estimated yearly cases*travel adjustment*proportion symptomatic

Outcome 5%, median, 95% values:8350, 11400, 16000

Rate of total illness per million: circa 2010

Outcome 5%, median, 95% values:380, 515, 760

Foodborne multiplier:Based on Delphi 2005

PERT Minimum, modal, maximum values:0.04, 0.31, 0.74

Total foodborne illness: Total illness*Foodborne multiplier

Outcome 5%, median, 95% values:1400, 3750, 7150

Rate of foodborne illness per million: circa 2010

Outcome 5%, median, 95% values:65, 170, 325

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Vibrio parahaemolyticus

Primary data: Western Australia notifications Alternate data:

Model input, source & comments Distribution Data for model input

Reported illness:WA notificationshttp://www.public.health.wa.gov.au/cproot/4195/2/12172_DiseaseWAtch.pdf

Empirical By year (2006–2010):3, 9, 7, 9, 10

Population adjustment:Australian resident population 2006–2010 June quarterhttp://www.abs.gov.au/AUSSTATS/[email protected]/DetailsPage/3101.0Dec%202011?OpenDocument (Accessed on 16/8/12)

Empirical By year (2006–2009):20697880, 21015936, 21384427, 21778845

Correction factor:WA population - June quarterBy year (2006–2009):2059381, 2113841, 2178577, 2246659, 2296129Australian population/WA Population

Constant 9.61

Domestically acquired multiplier:OzFoodNet WA Annual Reports 2006–2010

PERT Minimum, modal, maximum values:0, 0.18, 0.33

Underreporting:

Multiplier used to adjust for underreporting from surveillance to community (S-C)Non-typhoidal Salmonella multiplier adapted from Hall et al.22

Log normal Mean, standard deviation:7.44, 2.38

Total illness:Reported cases (WA surveillance)*correction factor*travel adjustment*underreporting(S-C)

Outcome 5%, median, 95% values:15, 60, 170

Rate of total illness per million: circa 2010

Outcome 5%, median, 95% values:1, 3, 8

Foodborne multiplier:Based on Delphi 2005

PERT Minimum, modal, maximum values:0.05, 0.75, 0.96

Total foodborne illness: Total illness*Foodborne multiplier

Outcome 5%, median, 95% values:10, 40, 120

Rate of foodborne illness per million: circa 2010

Outcome 5%, median, 95% values:0, 2, 6

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Yersinia enterocolitica

Primary data: State and territory notifications Alternate data:

Model input, source & comments Distribution Data for model input

Reported illness:State notifications from Queensland, SA, WA, and NT extrapolated from state data to the Australian population to determine the expected number of notifications if all states were reporting

Empirical By year (2006–2010)214, 249, 326, 242

Population adjustment:Australian resident population 2006–2010 June quarter

Empirical By year (2006–2010):20697880, 21015936, 21384427, 21778845, 22065317

Queensland resident population (June quarter)

By year (2006–2010):4090908, 4177089, 4270091, 4365426, 4424158

SA resident population (June quarter) By year (2006–2010):1567888, 1582559, 1597343, 1614375, 1629434

WA resident population (June quarter) By year (2006–2010):2059381, 2113841, 2178577, 2246659, 2296129

NT population (June quarter)http://www.abs.gov.au/AUSSTATS/[email protected]/DetailsPage/3101.0Dec%202011?OpenDocument (16/8/12)Notifications / estimated Australian population

By year (2006–2010)210627, 215021, 220935, 226841, 230315

Domestically acquired multiplier:OzFoodNet WA Annual Reports 2006–2010

PERT Minimum, modal, maximum values:0.8, 0.9, 1

Underreporting:

Multiplier used to adjust for underreporting from surveillance to community (S-C)Non-typhoidal Salmonella multiplier adapted from Hall et al.22

Log normal Mean, standard deviation:7.44, 2.38

Total illness:Reported cases (Extrapolated state notifications)*travel adjustment*underreporting(S-C)

Outcome 5%, median, 95% values:900, 1500, 2500

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109Foodborne illness in Australia circa 2010

Model input, source & comments Distribution Data for model input

Rate of total illness per million: circa 2010

Outcome 5%, median, 95% values:40, 70, 115

Foodborne multiplier:Based on Delphi 2005

PERT Minimum, modal, maximum values:0.28, 0.84, 0.94

5%, median, 95% values:30, 50, 90

Outcome 5%, median, 95% values:650, 1150, 1950

Rate of foodborne illness per million: circa 2010

Outcome 5%, median, 95% values:30, 50, 90

Yersinia enterocolitica (continued)

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