fluid flow and species transport around a scaffold
DESCRIPTION
Centro Interdipartimentale di Fluidodinamica e Idraulica University of Udine - Italy. Fluid flow and species transport around a scaffold. F. Beux, M. Campolo, A. Soldati. Centro Interdipartimentale di Fluidodinamica e Idraulica & Department of Energy & Technology, University of Udine, Italy. - PowerPoint PPT PresentationTRANSCRIPT
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Fluid flow and species transport around a Fluid flow and species transport around a
scaffoldscaffold
Centro Interdipartimentale di Fluidodinamica e Idraulica &
Department of Energy & Technology, University of Udine, Italy
F. Beux, M. Campolo, A. SoldatiF. Beux, M. Campolo, A. Soldati
Centro Interdipartimentale di Fluidodinamica e Idraulica
University of Udine - Italy
Prepared for VIVABIOCELL
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Problem
The flow field controls:• Conditions for cell adhesion and growth• Transport of nutrients
34 mm
6 mm
6 mm
Φ=4 mm
Q=4 cm3/min
Re=21
Water
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Objects
A. Evaluate the flow conditions inside the bioreactor to:
• Establish the actual throughput• Verify the flow homogeneity (possibility to feed
nutrients/remove catabolites, presence of dead regions)• Quantify the shear distribution (relevant for cellular growth)
B. Identify possible design modification to improve performances
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Computational domain
¼ overall domain
About 450.000 FV
> 10 FV
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1. Results: pressure drop & power
Maximum pressure drop in small connecting pipes(increase diameter if P is too high)
∆p=160 Pa
P=10-5 W
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2. Results: flow field homogeneity (in-out)
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2. Results: flow field homogeneity (corner)
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2. Results: velocity in volume
Maximum velocity in small connecting pipes
Minimum velocity in the flow diffuser
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3. Results: shear stress @ scaffold wall
p=8e-5÷0.03 Pa
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3. Results: shear stress statistics
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Average shear stress variation along scaffold
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Concluding remarks
1. In-Out pressure drop depends on number and diameter of connecting pipes
2. Flow homogeneity con be improved by changing the angular position of inlet/outlet connecting pipes (45°)
3. Possibility to evaluate transport (and reaction) of species