Flow Focusing®: Select Size

0.9 microns 5 microns 15 microns

350 microns 1500 microns

3500 microns

7000 microns

50 microns

Flow Focusing®: Select Structure

37 microns

11 microns

15 microns

5 microns

High value Starting Material, FF®

Lactobacillus, 31 microns

Omega 3, ~ 80 microns

Flavour , 40 microns

Peptide, 800 nanometers (0.8 microns)

Anti inflammatory, 8 microns

Vitamin A, ~ 90 microns

Formulation → FF® → Hardening

HARDENING

Spray Drying

Spray Chilling

Extraction/Evaporation

Ionic Gelation

FORMULATION

Homogeneous solutions

Emulsions

Suspensions

Maltodextrin, 22 microns

API 12 microns

Formulation → FF® → Hardening

HARDENING

Spray Drying

Spray Chilling

Extraction/Evaporation

Ionic Gelation

FORMULATION

Homogeneous solutions

Emulsions

Suspensions

Protein, 14 microns

Oily emulsion 38 microns

Formulation → FF® → Hardening

HARDENING

Spray Drying

Spray Chilling

Extraction/Evaporation

Ionic Gelation

FORMULATION

Homogeneous solutions

Emulsions

Suspensions Lactobacilus, 31 microns

Magnetic nanoparticles, 5 microns

Formulation → FF® → Hardening

HARDENING

Spray Drying

Spray Chilling

Extraction/Evaporation

Ionic Gelation

FORMULATION

Homogeneous solutions

Emulsions

Suspensions Oily emulsion 38 microns

Flavor 37 microns

Formulation → FF® → Hardening

HARDENING

Spray Drying

Spray Chilling

Extraction/Evaporation

Ionic Gelation

FORMULATION

Homogeneous solutions

Emulsions

SuspensionsOmega 3, ~ 80 microns

Flavor 40 microns

Formulation → FF® → Hardening

HARDENING

Spray Drying

Spray Chilling

Extraction/Evaporation

Ionic Gelation

FORMULATION

Homogeneous solutions

Emulsions

Suspensions

Magnetic nanoparticles, 5 microns

Protein, 14 microns

Formulation → FF® → Hardening

HARDENING

Spray Drying

Spray Chilling

Extraction/Evaporation

Ionic Gellation

FORMULATION

Homogeneous solutions

Emulsions

SuspensionsLactobacilus, 31 microns

Stem cells, ~170 microns

Flow Focusing®

3-D focusing of the jet by means of a mechanical process: pressurized air, gas or liquid.

No smashing, no electricity, no chemical process needed.The same nozzle allows the direct production of selectable sizes within an ample range.

Flow Focusing® is able to very gently produce microparticles of required composition and dimension, all the same as each other. The jet goes out through the outlet without touching it.

Flow Focusing® microencapsulation

Homogeneous solutions, suspensions, emulsions, melted substances, etc

Developed formulation

Ionic gelation, hot air, extraction evaporation …

Solidification/ Hardening

air or water

High Value Starting Material +Additives +Polymeric Matrix

Focusing

Concentric Flow Focusing® microencapsulation

Outer layer -Polymeric Matrix + Additives

Homogeneous solutions, suspensions, emulsions, etc

Most common formulation

Ionic gelation, hot air, extraction evaporation …

Solidification/ Hardening

Focusing with air or water

Homogeneous solutions, suspensions, emulsions, melted substances, etc

Inner layer –High Value Starting Material + Additives

Flow Focusing® Advantages

Desired Size: for each way of administration

From mm down to several hundreds nm

Easy and simple: in just one step

High Accuracy: dose control, cost effective, CV < 8%

No sieving, filtering, no cyclones, no additional steps

Versatility: No limits on formulation, any liquid

We just need a liquid or a emulsion to make it flow

Validated for many different substances and shell materials

Very smooth mechanical process:

Extra stability and bioavailability

Ingeniatrics’ capacities

3 pilot-plants, 2 assembly rooms:

Pharmaceutical – ISO 9001, ISO 14001, ISO 7 - GMP,* *in progress

Food – ISO 9001, IS0 14001, AESAN Regulation CE 853/2004, ISO 8

Chemistry – ISO 9001, ISO 14001

Ingeniatrics’ Capabilities

QUICK SPEC ON INGENIATRICS' CAPABILITIESF. Focusing® Nozzles SD FF100, SD FF200, SD FF 350, SD

FF500, SD FF700

From several microns to tens/hundreds of microns

F. Focusing® Concentric Nozzles SD cFF 350, SD cFF500 From several microns to tens of microns

F. Blurring® Nozzles SD FB240, SDFB500 From nanometers to few tens of microns

Polymers Gums: Arabic gums, shellac, etc.Celluloses: EC, CMC, HPMCP, etcAcrylic derivatives: Eudragits (S100, E100, NM30D), etc Polyvinyl derivatives: Sureteric, Kollidon, etcPoly ester derivatives: PLGAOthers: Lactose, maltodextrine, alginates, mixtures of various

Products in formulation Drugs, Food ingredients, Oils (by emulsification), enzymes, particles (suspensions), Additives (glidance, adsorbents, plasticizers, etc)

Products in inner core(for concentric) Emulsions, fragrances, drugs, oils, pigments, etc ..

Business Model (II)

Our technological service offer Development & Production of high value microspheres based on our proprietary technology for Microencapsulation:

Study and evaluation of starting material. Design of innovative solutions for the required application

based on our technology. Pre-formulation studies and technology fitting. Microparticle characterization : morphology, composition, analytical methods, etc. Initial studies: stability, drug delivery profiles…

Scale-up and microparticle production.PI Parque Plata. C/Camino Mozárabe, 4141900 Camas, Sevilla. España/Spain

T. (+34)954 081 214 F. (+34)955 98022518