Submmited to: prof. kunal joshi

Flying view of company

1972 - The Company was incorporated on 15th July, as a Private Limited Company by Shri Rajnikant C. Patel and his family members, and in June 1982, the company was acquired by Shri Uttamlal N. Mehta. - The Company is primarily engaged in the manufacture of various Pharmaceuticals formulations and bulk drugs. The products of the Company enjoy good reputation and are well accepted in the market. - The Company has taken up manufacture of bulk drugs as a strategic value added backward integration to its formulation activities. 1989 - On 28th June the Company became a deemed Public Company under the provisions of Section 43-A of the Act and by a Special Resolution passed on 25th July, 1992 at the Annual General Meeting, the Company became a Public Limited Company within the meaning of Section 3(1)(iv) of the act and adopted a new set of articles. 1992 - Torrent Laboratories Limited, was amalgamated with the Company with effect from 1st April by an order of the Honourable High Court of Gujarat, dated 22nd December. - The Company proposes to undertake an expansion-cum modernization of its existing facilities, setting up facilities for manufacture of new products apart from setting up a separate in-house Research & Development Centre. - The Company further broad base its product range through in-house manufacture of Ranitidine HCL, Diltiazem, HCL and Atenolol with an installed capacity of 12 tpa each. - The company proposes to set-up in-house production facilities for Large Volume Parentrals with an installed capacity of 14.5 million bottles p.a. for better quality control and for diversifying the product range to include dextrose/saline injectibles and value added items like fluconazole infusion.

2006 -Torrent Pharma Receives USFDA Approval -Torrents Azuca launches 2 new blockbusters, Pregeb and Piopod -Entered into an in-licensing deal with Tasly of China to market its Cardiotonic pill in India -Torrent Pharmaceuticals Ltd has announced that the Company has launched Nexpro Fast (Immediate Release Esomeprazole), a Proton Pump Inhibitor (PPI), for the first time in India to treat peptic ulcers and GERD (Gastro Esophageal Reflux Disease). -The API and formulations manufacturing facilities located at Indrad (Gujarat, India) got US FDA approval -Torrent Pharma launches AzuCa, its super-specialty Diabetes division 2007 - Torrent unveils laxative in tablet form -Torrent Pharma launches CVpill, The worlds first polypill in Cardiac care -Indians to get slimmer and fitter: Torrent Pharma launches Rimoslim; Indias first Rimonabant -Torrent Pharma launches Fibotab; Indias first bulk laxative in tablet form 2009 -Torrents New Insulin Facility to produce 26 million vials pa for Novo Nordisk

Overview :: Torrents manufacturing facility at Indrad, Gujarat, was set up in 1989. Today, the Indrad facility is at par with international standards. It complies with WHO, cGMP, MHRA and TGA norms and has received ISO 9001, ISO 14001 and OHSAS 18001 (Occupational Health and Safety Management System) certifications; adequately reflecting Torrents commitment towards quality and safety. Attainment of such standards have also opened the key to gaining footholds in regulated, lucrative markets like the US and EU for Torrent Pharma.

Torrent firmly believes that quality can not be talked into a product, but has to exist inherently. Its efforts towards realizing world-class quality standards came into limelight with the Quality Excellence Gold Award received from the Indian Drug Manufacturers Association (IDMA) for four consecutive years viz. 2000, 2001, 2002 and 2003. Infrastructure ::y y y y y y

Land - 178,000 sq. metres Built-up Area - 50,000 sq. metres for Formulations, 10,000 sq. meters for API Excellent Support Services Finished Products - Oral Dosage Form, Injectables, Freeze Dried Sterile Injections API - Multi Product, Versatile Facility, Upgraded to International Standards Hygiene Zones Process step dependent special zones created for each type of activity

Manufacturing Capacities (per annum) :: Formulations - Tablets, 6,000 capsules and vials million Bulk Drugs/API 15,000 kg

Tie-up with Novo Nordisk :: We have signed an agreement with Novo Nordisk India in August 2005 and part of our parenteral facility is dedicated for the formulation and packaging of Insulin, exclusively for Novo Nordisk. The facility will cater to the increased demand for Novo Nordisk Insulin products in India and will incorporate state of art technology in formulation, filling, inspection and packaging of Novo Nordisk insulin formulations. This facility will have the requisite flexibility to expand and the production will be done with the same state of the art technology and quality standards as practiced across the world by Novo Nordisk. We have been manufacturing Insulin for Novo Nordisks India requirement for more than 15 years now. Our parenteral site for insulin production is dedicated for Novo Nordisk products, and complies with their worldwide norms. On numerous occasions, we have won the award for Best Maintained Manufacturing Site of Novo Nordisk worldwide.

Distribution

A well functioning distribution system is a pre-requisite in any consumer goods industry and more so in pharma due to limited shelf life of products. This area has been under continuous focus for improvement. The key initiatives for the year involved automating the processes at various levels in the supply chain system and improving the flow of data for market planning and control. The debtors credit and collection system was also completely overhauled resulting in a considerable reduction on overdue debtors. The Value Added Tax (VAT) was proposed to be introduced by all the State Governments from April 2003 in replacement of the current sales tax laws. As in the past, this was once again postponed. VAT has created considerable confusion and uncertainties amongst the trade channel and is repeatedly affecting the primary sales of the Company. In the medium term, the implementation of VAT is also expected to result in a restructuring of the distribution structure, for which your Company is gearing up.

Sales Force Automation System : Development, Rollout and Change Management

Sales force management systems are information systems used in marketing and management that automate some sales and sales force management functions. They are frequently combined with a marketing information system, in which case they are often called customer relationship management systems. When I was employed with Torrent Pharmaceuticals Limited (www.torrentpharma.com), SFA was the first project I got to work on. Torrent has over 800 products registered in over 27 countries. Torrent created an IT enabled Business Environment through deployment of SAP in its headquarter, two manufacturing plants, one research center and numbers of foreign subsidiaries. But, people who were always on move, who really generated the sales for the company - the strong sales force of 3000+ people; did not get any direct benefit of this IT enabled Business Environment. For them, a separate system catering to their specific needs was required. That gave birth to idea of SFA roll out. Our business case was: 1. Wanted to minimize/eliminate writing work 2. Improve productivity 3. Better Customer, Business, Industry focus 4. Data capturing at source 5. Immediate feedback from seniors 6. Free up time for high value activities 7. Morale of field force 8. Online availability of Sales, Goods return and stock data 9. Torrent news from HO/Market 10. Discussion forums 11. E-Mail & Medical Information 12. Increase in productivity & earnings 13. Overall Gain Competitive Advantage

Approach to a problem & Change Management Following figure illustrates the hierarchy of Sales Force

Typically, in other pharma companies, requirements were gathered from HQ; who does not know actual problems in field, develop the system and then force the system on sales force. These were always a failure. But, we took different pathway. We wanted to involve Sales Force - the actual user; in every phase of development. We wanted them to own the system. We selected a team of actual users for pilot testing. And then...y y y y y

Launched the system for one zone at a time First zone with only basic functionality Every next zone with improved interface and useful features developed with input from previous zones Sufficient training and testing time given before LIVE date for each zone Time gap between two zone going LIVE Following figure illustrates the SFA Architecture

In our training to sales force, we also faced problem like people with zero computer literacy. We treated them separately by giving them computer knowledge first. 24 Hours telephonic support was given. In initial roll out, many time I received calls for support around 2AM during month end(closing time). In the end, I and my team were gained by the knowledge of functions and sales life cycle of a pharmaceutical company. But, most important to us was, we were able to simplify life of sales representatives; that was our real success.

Supply Chain Management Facility :: Supply Chain Management activities at the manufacturing plant mainly include: Production Planning / Inventory Control / Warehousing / Information Technology. It coordinates with the Procurement Division for timely availability of inputs and with Marketing Department to make all products available timely, as per the requirements, and distribution of products to C & F Agents all over the country, and of finished goods to Cargo Handling Agents for exports. Production Planning and Control :: It is one of the core functions of all the manufacturing activities Activities include y y y

Production Planning Indent of raw material and packaging material. Inventory monitoring to meet with marketing requirements

Raw Material Stores :: RM Stores has 100% controlled environment storage for active and inactive raw materials. Dispensing of raw material as per prevailing cGMP norms and SOPs. Facilities y y y

Separate Areas like Receipt, Under Test and Approved raw materials. 3 Separate Sampling Booths with Reverse Laminar Air Flow System. 4 Dispensing Booths with Reverse Laminar Air Flow System.

Packing Material Store ::y y y y

Separate area for Receipt/ Under test and Approved Materials All packaging materials are stored as per cGMP guidelines and procedures laid down in SOPs. Maintaining controlled environment for primary packaging materials. Dispensing batch-wise as per SOPs.

Bonded Store Room (BSR) ::y y

Formulations and API are kept in BSR in controlled environmental conditions. Facilities are also available for cold chain products

y y

The finished products are dispatched from BSR to Duty Paid Store for Domestic sales after compliance of Central Excise Duty formalities. Dispatches of finished goods to Cargo Handling Agents for Exports

Duty Paid Store (DP Store) ::y y y

Storage facility available for controlled condition and cold chain products. Country wide 22 C & F Agents catered by DP stores. Promotional inputs dispatches to concerned Marketing Field Force.

Active Pharmaceutical Ingredients Store (API Store) ::y y y y y

Activities similar to raw materials stores of formulation plant are undertaken Caters to the requirements of API manufacturing facilities. Handles bulk storage of various chemicals, solvents and hazardous materials Facility available to store the RMs in controlled environment Utmost care, safety precautions to maintain better working conditions.

ERP IN TORRENT PHARMA

Pharma ERP CCE Software has designed and developed GMP compliant Pharma ERP, which is a comprehensive solution for Pharmaceutical Manufacturing. The ERP solution complies with GAMP norms and 21 CFR Part 11 guidelines Why Pharma ERP for your business? Whether you need to increase your market share or be more profitable, Pharma ERP solution can help you achieve your goals and bring significant return on your investment. It provides you with enhanced effectiveness , improves the efficiency of the processes and streamline internal operations. Pharma ERP by CCE Software offers a gamut of modules that can be customized, seamlessly integrated and implemented in modular form to suit your business needs. CCE offers Pharma ERP with Complete Validation (IQ. OQ & PQ). Pharma ERP Modules Admin Vendor approval process Materials Management Stores and Excise Production Planning & Control Maintenance Management Warehousing Audit trail SOP document management Quality Sales, Distribution & Marketing Finance MIS

Tablet Facility ::y y

y y

Tablet facility: Modernized / Upgraded to Meet International Standards. Department has following Hygiene Zones: o 'O' Area - Products exposed to environment o 'E' Area - Products in close containers o Entry from 'E' to 'O' area is restricted by separate gowning procedure. Area-wise personnel and material movement through separate air lock. All manufacturing area has 100% fresh air to avoid cross contamination.

Equipments ::y y y y y y y

Wet Granulation Dry Compaction / Granulation Pellet Coating Film Coating Enteric Coating Sugar Coating Bilayer Tablet

Equipments :: MACHINE Mechanical Sifter Commniting mill Drum Blender Jacketed Planetory Mixer TOTAL QTY 6 4 1 2 450 Lit / 900 Lit 100 Kg / Hr CAPACITY 100 Kg / Hr 150 Kg / Hr 100 Kg

Rapid Mixer & 1/1 Granulators Roll Compactor 1

Fluid Dryers Turbo Sifters

Bed 1/1 1/1 2

160 Kg. / 300 Kg. 160Kg. / 300 Kg 320 Lit

Cage Blenders

Fluidized Bed 1 Processor (Glatt Gmbh) Lifting Positioning Device Tipplers Compression Machines Coaters & 1/1

160 Kg. / 300 Kg 150 Kg / Hr 6.0 Million Tabs / Shift 300 Kg 160 Kg

2 8 1 4