Cumulative List of all Products that have received Orphan Designation: Total active designations: 2002 Effecive: 5/5/2009Generic Name Trade Name Designated Indication Marketing Approved Indication Designated Date Market Exculsivity Date

CNJ-016 Treatment of complications of vaccinia vaccination 6/18/2004 5/1/9999

ReFacto 2/8/1996 1/1/9999

Potassium Iodide Oral Solution ThyroShield 11/17/2004 1/1/9999

Curosurf 8/2/1993 1/1/9999

Somatropin (rDNA origin) Saizen 3/6/1987 1/1/9999

Somatropin (rDNA origin) Nutropin Depot 10/28/1999 1/1/9999

Somatropin (rDNA origin) injection Norditropin 7/10/1987 1/1/9999

Infasurf 6/7/1985 1/1/9999

Trypan blue MembraneBlue 8/2/2006 2/20/2009

Recombinant human antithrombin ATryn 12/7/2007 2/6/2009

RiaSTAP Treatment of fibrinogen deficient patients 3/13/2008 1/16/2009

Treatment of B-cell chronic lymphocytic leukemia 12/18/2007 12/18/2008

plerixafor Mozobil 7/10/2003 12/15/2008

eltrombopag Promacta Treatment of idiopathic thrombocytopenia purpura 5/5/2008 11/20/2008

Vaccinia Immune Globulin (Human) Intravenous

treatment and/or modification of the following conditions, which are complications resulting from smallpox vaccination: Eczema vaccinatum

Antihemophilic factor (recombinant)

For the control and prevention of hemorrhagic episodes and for surgical prophylaxis in patients with hemophilia A (congenital factor VIII deficiency or classic hemophilia).

For use as a thyroid blocking agent in pediatric patients exposed to radiactive iodine

For use as a thyroid blocking agent in pediatric patients exposed to radiactive iodine

Pulmonary surfactant replacement, porcine

For the treatment and prevention of respiratory distress syndrome in premature infants.

Treatment (rescue) of respiratory distress syndrome in premature infants.

Treatment of idiopathic or organic growth hormone deficiency in children with growth failure.

Long term treatment of children with growth failure due to inadequate secretion of endogenous growth hormone.

Long-term treatment of children who have growth failure due to a lack of adequate endogenous growth hormone secretion.

Long-term treatment of growth failure due to a lack of adequate endogenous growth hormone secetion for once- or twice-a-month administration.

Treatment of growth failure in children due to inadequate growth hormone secretion.

Long-term treatment of children who have growth failure due to inadequate secretion of endogenous growth hormone.

Surface active extract of saline lavage of bovine lungs

Treatment and prevention of respiratory failure due to pulmonary surfactant deficiency in preterm infants.

Treatment and prevention of respiratory failure due to pulmonary surfactant deficiency in preterm infants.

Selectively staining epiretinal membranes during ophthalmic surgical victrectomy procedures

For use as an aid in ophthalmic surgery by staining the epiretinal membranes during ophthalmic surgical vitrectomy procedures,

Treatment of congenital antithrombin deficiency to prevent the occurrence of serious, potentially life-threatening venous thromboembolisms which may develop as a result of surgical or obstetrical procedures

Prevention of peri-operative and peri-partum thromboembolic events, in hereditary antithrombin deficient patients.

human fibrinogen concentrate, pasteurized

Treatment of acute bleeding episodes in patients with congenital fibrinogen deficiency (afibrinogenemia and hypofibrinogenemia

Fludarabine phosphate oral tablets

Treatment of adult patients with B-cell chronic lymphocytic leukemia (CLL) whose disease has not responded to or has progressed during or after

For use to improve the yield of progentor cells in the apheresis product for subsequest stem cell transplantation following myelosuppressive or myeloablative chemotherapy

To enhance mobilization of hematopoietic stem cells to the peripheral blood for collection and subsequent autologous Treatment of thrombocytopenia in patients with chronic immune (idiopathic) thrombocytopenic purpura who have had an insufficient response

rufinamide Banzel Treatment of Lennox-Gastaut Syndrome. 10/8/2004 11/14/2008

C1 esterase inhibitor (human) Cinryze Treatment of angioedema 7/16/2004 10/10/2008

Iobenguane I 123 AdreView For the diagnosis of pheochromocytomas 12/1/2006 9/19/2008

Iobenguane I 123 Adreview For the diagnosis of neuroblastomas 12/1/2006 9/19/2008

Immune Globulin (Human) Gamunex 7/27/2004 9/12/2008

romiplstim Nplate Treatment of immune thrombocytopenic purpura 3/27/2003 8/22/2008

Tetrabenazine Xenazine Treatment of Huntington's disease 12/11/1997 8/15/2008

Sorafenib Nexavar Treatment of hepatocellular carcinoma 4/20/2006 3/24/2008

Bendamustine hydrochloride Treanda Treatment of chronic lymphocytic leukemia 8/17/2007 3/20/2008

Levoleucovorin 8/1/1991 3/7/2008

Rilonacept Arcalyst Treatment of CIAS1-Associated Periodic Syndromes 12/20/2004 2/27/2008

Adalimumab Humira Treatment of juvenile rheumatoid arthritis 3/21/2005 2/21/2008

Adjunctive therapy of seizures associated with Lennox-Gastaut syndrome.

Routine prophylaxis against angioedema attacks in patients with Hereditary Angioedema (HAE)

To be used in the detection of primary or metastatic pheochromocytomas or neuroblastomas as an adjunct to other diagnostic tests

To be used in the detection of primary or metastatic pheochromocytomas or neuroblastomas as an adjunct to other diagnostic tests

Treatment of chronic inflammatory demyelinating polyneuropathy

Treatment of Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) to improve neuromuscular disability and impairment and for maintenance therapy to prevent relapseTreatment of thrombocytopenia in patients with chronic immune (idiopathic) thrombocytopenic purpura (ITP) who have had an insufficient

Treatment of chorea associated with Huntington's disease

Treatment of unresectable hepatocellular carcinoma

Treatment of patients with chronic lymphocytic leukemia

For use in conjunction with high-dose methotrexate in the treatment of osteosarcoma.

Levoleucovorin rescue is indicated after high-dose methotrexate therapy in osteosarcoma. Levoleucovorin is also indicated to diminish the toxicity

Treatment of Cryopyrin-Assisted Periodic Syndromes (CAPS)

Treatment of Juvenile Idiopathic Arthritis

Thyrotropin alfa Thyrogen 8/3/2001 12/14/2007

sapropterin Kuvan Treatment of hyperphenylalaninemia 1/29/2004 12/13/2007

Nilotinib Tasigna Treatment of chronic myelogenous leukemia 4/27/2006 10/29/2007

Raloxifene Evista 7/14/2005 9/13/2007

dexrazoxane Totect 3/25/2004 9/6/2007

Lanreotide Somatuline Depot Treatment for acromegly 9/11/2000 8/30/2007

ambrisentan Letairis Treatment of pulmonary arterial hypertension 7/16/2004 6/15/2007

Somatropin Norditropin 8/9/2006 5/31/2007

Temsirolimus Torisel Treatment of renal cell carcinoma 12/16/2004 5/30/2007

Doxil Treatment of multiple myeloma 12/29/2004 5/17/2007

Histrelin Supprelin LA Treatment of central precocious puberty 11/18/2005 5/3/2007

HepaGam 3/24/2008 4/6/2007

Protein C concentrate Ceprotin 6/23/1992 3/30/2007

eculizumab Soliris Treatment of paroxysmal nocturnal hemoglobinuria 8/20/2003 3/16/2007

Treatment of well-differentiated papillary, follicular or combined papillary/follicular carcinomas of the thyroid

For use as an adjunctive treatment for radioiodine ablation of thyroid tissue remnants in patients who have undergone thyroidectomy for well-Indicated to reduce blood phenylalanine (Phe) levels in patients with hyperphenylalaninemia (HPA) due to tetrahydrobiopterin- (BH4-)

For the use for chronic phase (CP) and accelerated phase (AP) Philadelphia chromosome positive chronic myelogenous leukemia

Reduction of the risk of breast cancer in postmenopausal women

Reduction in risk of invasive breast cancer in postmenopausal women with osteoporosis and reduction in risk of invasive breast cancer in

Treatment of anthracycline extravasation during chemotherapy

Treatment of extravasation resulting from IV anthracycline chemotherapyLong-term treatment of acromegalic patients who have had an inadequate response to or cannot be treated with surgery and/or radiotherapyTreatment of pulmonary arterial hypertension (WHO group I) in patients with WHO class II or III symptoms to improve exercise

Treatment of short stature in patients with Noonan syndrome

Treatment of short stature in patients with Noonan syndrome

Treatment of advanced renal cell carcinoma

Doxorubicin HCL liposome injection

For use in combination with bortezomib for the treatment of patients with multiple myeloma who have not previously received

Treatment of central precocious puberty

hepatitis B immune globulin (human)

Prevention of hepatitis B recurrence following orthotopic liver transplant

Prevention of hepatitis B recurrence following liver transplantation in HBsAG-positive liver transplant patients

For replacement therapy in congenital protein C deficiency for the prevention and treatment of thrombosis, pulmonary emboli, and purpura fulminans.

Prevention and treatment of venous thrombosis and purpura fulminans

Treatment of paroxysmal nocturnal hemoglobinuria to reduce hemolysis

Antihemophilic factor (human) Alphanate Treatment of von Willebrand's disease 1/5/1996 1/31/2007

Balsalazide disodium Colazal Treatment of pediatric patients with ulcerative colitis 8/12/2005 12/20/2006

Hydroxocobalamin Cyanokit Treatment of acute cyanide poisoning 11/25/2003 12/15/2006

Imatinib mesylate Gleevec 9/9/2005 10/19/2006

Imatinib mesylate Gleevec 10/5/2005 10/19/2006

Imatinib mesylate Gleevec 8/25/2005 10/19/2006

imatinib mesylate Gleevec 10/11/2005 10/19/2006

imatinib mesylate Gleevec Treatment of dermatofibrosarcoma protuberans 12/19/2005 10/19/2006

NovoSeven 7/21/2004 10/13/2006

NovoSeven 7/16/2004 10/13/2006

vorinostat Zolinza Treatment of T-cell non-Hodgkin's lymphoma 3/16/2004 10/6/2006

biocarbonate infusate Normocarb HF 8/9/2005 7/26/2006

idursulfase Elaprase 11/28/2001 7/24/2006

lenalidomide Revlimid Treatment for multiple myeloma 9/20/2001 6/29/2006

For surgical and/or invasive procedures in patients with von Willebrand Disease (VWD) in whom desmopressin is either ineffective or Treatment of mildly to moderately active ulcerative colitis in patients 5 years of age and older. Safety and Effectiveness of Colazal beyond 8

Treatment on known or suspected cyanide poisoning

Treatment of systemic mastocytosis without the D816V c-kit mutation

Treatment of adult patients with aggressive mastocytosis (ASM) without the D816V c-Kit mutation or with c-Kit mutational status unknown

Treatment of myeloproliferative disorders/myelodysplastic syndromes associated with platelet-derived growth factor gene re-arrangements

Treatment of adult patients with myelodysplastic/myeloproliferative diseases (MDS/MPD) associated with PDGFR (platelet-derived growth

Treatment of idiopathic hypereosinophilic syndrome including acute and chronic eosinophilic leukemia

Treatment of adult patients with hypereosinophic syndrome (HES) and/or chronic eosinophilic leukemia (CEL) who have the FIP1L1-PDGFRα

Treatment of Philadelphia-positive acute lymphoblastic leukemia

Treatment of adult patients with relapsed or refractory Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ALL)Treatment of adult patients with unresectable, recurrent and/or metastatic dermatofibrosarcoma protuberans (DFSP)

Coagulation factor VIIa (recombinant)

Prevention of bleeding episodes in patients with acquired inhibitors to Factor VIII or Factor IX

Prevention of bleeding in surgical interventions or invasive procedures in patients with acquired hemophilia

Coagulation Factor VIIa (Recombinant)

Treatment of bleeding episodes in patients with acquired inhibitors to Factor VIII or Factor IX

Treatment of bleeding episodes in surgical interventions or invasive procedures in patients with acquired hemophiliaTreatment of cutaneous manifestations in patients with cutaneous T-cell lymphoma (CTCL) who have progressive, persistant or

Use in the management of patients undergoing continuous renal replacement therapy with hemofiltration

Use as a replacement solution in Continuous Renal Replacement Therapy (CRRT) to replace water and to correct electrolytes and acid-base

Long term enzyme replacement therapy for patients with mucopolysaccharidosis II (Hunter Syndrome)

Indicated for patients with Hunter syndrome (mucopolysaccharidosis II, MPS II). Idursulfase has been shown to improve walking capacity in these For use in combination with dexamethasone for the treatment of multiple myeloma patients who have received at least one prior therapy.

Dasatinib Sprycel 11/18/2005 6/28/2006

Dasatinib Sprycel Treatment of chronic myelogenous leukemia 11/28/2005 6/28/2006

Thalidomide Thalomid Treatment of multiple myeloma 10/14/1998 5/25/2006

Infliximab REMICADE 11/12/2003 5/19/2006

Decitabine Dacogen Treatment of myelodysplastic syndromes. 3/8/1999 5/2/2006

Myozyme Treatment of glycogen storage disease type II. 8/19/1997 4/28/2006

Ibuprofen lysine NeoProfen Treatment of patent ductus arteriosus. 10/29/1996 4/13/2006

Tacrolimus Prograf 6/6/2005 3/29/2006

Cetuximab Erbitux 7/3/2000 3/1/2006

lenalidomide Revlimid Treatment of myelodysplastic syndromes 1/29/2004 12/27/2005

Sorafenib Nexavar Treatment of renal cell carcinoma. 10/8/2004 12/20/2005

mecasermin rinfabate iPLEX 5/17/2002 12/12/2005

oxybate Xyrem Treatment of narcolepsy 11/7/1994 11/18/2005

Deferasirox Exjade 11/21/2002 11/2/2005

Treatment of Philadelphia-positive acute lymphoblastic leukemia

Treatment of adults with Philadelphia chromosome-positive acute lymphoblastic leukemia with resistance or intolerance to prior Treatment of adults with chronic myeloid leukemia with resistance or intolerance to prior therapy including imatinib

Treatment of patients with newly diagnosed multiple myeloma

Treatment of pediatric (0 to 16 years of age) Crohn's Disease

For reducing signs and symptoms and inducing and maintaining clinical remission in pediatric patients with moderately to severely active Crohn's for treatment of patients with myelodysplastic syndromes (MDS) including previously treated and untreated, de novo and secondary

Recombinant human acid alpha-glucosidase

For use in patients with Pompe disease (GAA deficiency). Alglucosidase alfa has been shown to improve ventilator-free survival in For closure of a clinically significant patent ductus arteriosus in premature infants weighing between 500 and 1500 g, who are no more than 32

Prophylaxis of organ rejection in patients receiving heart transplants.

Prophylaxis of organ rejection in patients receiving allogenic heart transplants.

Treatment of squamous cell cancer of the head and neck in patients who express epidermal growth factor receptor.

For use in combination with radiation therapy, for the treatment of locally or regionally advanced squamous cell carcinoma of the head and neck Treatment of patients with transfusion dependant anemia due to low or intermediate-1 risk myelodysplastic syndromes associated with a deletion

Treatment of patients with advanced renal cell carcinoma

Treatment of growth hormone insensitivity syndrome (GHIS)

Treatment of growth failure in children with severe primary IGF-1 deficiency (Primary IGFD) or with growth hormone (GH) gene deletion who

Treatment of excessive daytime sleepiness in patients with narcolepsy

Treatment of chronic iron overload in patients with transfusion-dependent anemias

Treatment of chronic iron overload due to blood transfusions (transfusional hemosiderosis) in patients 2 years of age or older

nelarabine Arranon 8/10/2004 10/28/2005

Mecasermin Increlex Treatment of growth hormone insensitivity syndrome. 12/12/1995 8/30/2005

NovoSeven 6/18/2004 8/12/2005

quinine Sulfate Treatment of malaria 6/3/2004 8/12/2005

meloxicam Mobic Treatment of juvenile rheumatoid arthritis 11/22/2002 8/11/2005

NovoSeven 9/10/2004 7/11/2005

NovoSeven 9/10/2004 7/11/2005

Naglazyme 2/17/1999 5/31/2005

Fluocinolone Retisert 7/31/2000 4/8/2005

Bortezomib Velcade Treatment of multiple myeloma 1/15/2003 3/25/2005

temozolomide Temodar Treatment of malignant glioma 10/5/1998 3/15/2005

6/18/2004 2/18/2005

benzoate/phenylacetate Ammonul 11/22/1993 2/17/2005

Iloprost inhalation solution Ventavis Treatment of pulmonary arterial hypertension 8/17/2004 12/29/2004

clofarabine Clolar Treatment of acute lymphoblastic leukemia 2/7/2002 12/28/2004

Luveris 10/7/1994 10/8/2004

Treatment of acute lymphoblastic leukemia and lymphoblastic lymphoma

Treatment of patients with T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma whose disease has not responded to or has Long-term treatment of growth failure in children with severe primary IGF-1 deficiency (Primary IGFD) or with growth hormone (GH) gene deletion

Coagulation factor VIIa (recombinant)

Prevention of bleeding episodes in patients with hemophilia A or B, with or without inhibitors

Prevention of bleeding in surgical interventions or invasive procedures in hemophilia A or B patients with inhibitors to Factor VIII or Factor IX

Treatment of uncomplicated Plasmodium falciparum malariaFor relief of the signs and symptoms of pauciarticular or polyarticular course Juvenile Rheumatoid Arthritis in patients 2 years of age or older

Coagulation factor VIIa (recombinant)

Prevention of bleeding episodes in patients with congenital Factor VII deficiency

Prevention of bleeding in surgical interventions or invasive procedures in patients with congenital F VII deficiency

Coagulation factor VIIa (recombinant)

Treatment of bleeding episodes in patients with congenital factor VII deficiency

Treatment of bleeding episodes in patients with Factor VII Deficiency

N-acetylgalactosamine-4-sulfatase, recombinant human

Treatment of mucopolysaccharidosis Type VI (Maroteaux-Lamy syndrome).

For patients with mucopolysaccharidosis VI. Galsulfase has been shown to improve walking and stair-climbing

Treatment uveitis involving the posterior segment of the eye.

Treatment of chronic non-infectious uveitis affecting the posterior segment of the eye

Treatment of multiple myeloma patients who have received at least one prior therapyTreatment of adult patients with newly diagnosed glioblastoma multiforme concomitatly with radiotherapy and then as maintenance treatment

Vaccinia Immune Globulin (Human) Intravenous

Treatment of severe complications from the smallpox vaccine

Treatment and modification of aberrant infections induced by vaccinia virus that include its accidental implantation in eyes

Treatment of acute hyperammonemia and associated encephalopathy in patients with deficiencies in enzymes of the urea cycle.

Adjunctive therapy in the treatment of acute hyperammonemia and associated encephalopathy in patients with deficiencies in enzymes of the

Treatment of pulmonary arterial hypertension (WHO Group I) in patients with NYHA Class III or IV symptomsTreatment of pediatric patients 1 to 21 years old with relapsed or refractory acute lymphoblastic leukemia after at least two prior regimens

Recombinant human luteinizing hormone

For use in association with recombinant human follicle stimulating hormone for the treatment of women with chronic anovulation due to hypogonadotropic hypogonadism.

Luveris (lutropin alfa for injection), concomitantly administered with Gonal-f (follitropin alfa for injection), is indicated for stimulation of follicular

M.V.I.-12 3/8/2004 9/9/2004

4/28/2004 8/11/2004

Glutamine NutreStore 3/6/1995 6/10/2004

azacitidine Vidaza Treatament of myelodysplastic syndromes 12/3/2001 5/19/2004

tinidazole Tindamax Treatment of giardiasis 4/18/2002 5/17/2004

Tinidazole Tindamax Treatment of amebiasis 8/20/2003 5/17/2004

Apomorphine HCl Apokyn 4/22/1993 4/20/2004

cinacalcet Sensipar 5/12/2003 3/8/2004

pemetrexed disodium Alimta Treatment of malignant pleural mesothelioma 8/28/2001 2/4/2004

acetylcysteine Acetadote 10/19/2001 1/23/2004

Somatropin (r-DNA) Zorbtive 3/6/1995 12/1/2003

Botulism immune globulin BabyBIG Treatment of infant botulism. 1/31/1989 10/23/2003

iron(III)-hexacyanoferrate(II) Radiogardase 5/1/2003 10/2/2003

multi-vitiam infusion without vitamin K

Prevention of vitamin deficiency and thromboembolic complicationsin people receiving home parenteral nutrition and warfarin-type anticoagulant therapy

Prevention of vitamin deficiency and thrombormbolic complications in people receiving home parenteral nutrition who also receive warfarin-

Diethylenetriaminepentaacetic acid (DTPA)

Treatment of patients with known or suspected internal contamination with plutonium, americium, or curium to increase the rates of elimination.

Treatment of internal contamination with plutonium, americium or curium

For use with human growth hormone in the treatment of short bowel syndrome (nutrient malabsorption from the gastrointestinal tract resulting from an inadequate absorptive surface).

Treatment of short bowel syndrome in patients receiving specialized nutritional support when used in conjunction with a rercombinant Treatment of patients with the following myelodysplastic syndrome subtypes: refractory anemia or refractory anemia with ringed Treatment of giardiasis caused by G. duodenalis (also termed G. lamblia) in both adults and pediatric patients older than three years of ageTreatment of intestinal amebiasis and amebic liver abcess caused by E. histolytica in both adults and pediatric patients older than three years of age.

Treatment of the on-off fluctuations associated with late-stage Parkinson's disease.

For the acute, intermittent treatment of hypomobility, "off" episodes ("end-of-dose-wearing-off" and unpredictable :on/off" episodes)

Treatment of hypercalcemia in patients with parathyroid carcinoma

Treatment of hypercalcemia in patients with parathyroid carcinomaTreatment of patients with malignant pleural mesothelioma whose disease is either unresectable or who are otherwise not candidates for curative

For the intravenous treatment of moderate to severe acetaminophen overdose

For the use of Acetadote(registered TM) Injection, administered intravenously within 8 to 10 hours after ingestion of a potentially heptotoxic quantity of acetaminophen,

For use alone or in combination with glutamine in the treatment of short bowel syndrome.

Treatment of short bowel syndrome in patients receiving specialized nutritional supportIndicated for treatment of infant botulism caused by type A or type B Clostridium botulinum.

Treatment of patients with known or suspected internal contamination with radioactive or non-radioactive cesium or thallium

Treatment of patients with known or suspected internal contamination with radioactive cesium and/or radioactive or non-radioactive thallium to increase

porfimer Photofrin 10/19/2001 8/1/2003

miglustat Zavesca Treatment of Gaucher disease. 5/29/1998 7/31/2003

ribavirin REBETOL Treatment of chronic hepatitis C in pediatric patients 4/4/2003 7/29/2003

Bexxar Treatment of non-Hodgkin's B-cell lymphoma. 5/16/1994 6/27/2003

bortezomib Velcade Treatment of multiple myeloma 1/15/2003 5/13/2003

laronidase Aldurazyme Treatment of patients with mucopolysaccharidosis-I. 9/24/1997 4/30/2003

Fabrazyme Treatment of Fabry's disease. 1/19/1988 4/24/2003

Pegvisomant Somavert Treatment of acromegaly. 6/24/1997 3/25/2003

polifeprosan 20 with carmustine Gliadel Treatment of malignant glioma 12/13/1989 2/25/2003

Extraneal (with 7.5% I 7/18/1997 12/20/2002

nitazoxanide Alinia Treatment of intestinal giardiasis 2/14/2002 11/22/2002

Nitazoxanide Alinia Treatment of cryptosporidiosis. 12/12/1996 11/22/2002

Synthetic porcine secretin For use in the evaluation of exocrine pancreas function. 6/18/1999 11/1/2002

Buprenorphine hydrochloride Subutex Treatment of opiate addiction in opiate users. 6/15/1994 10/8/2002

For the ablation of High-Grade Dysplasia in Barrett's Esophagus in patients who are not considered to be candidates for esophagectomy

For the ablation of high-grade dysplasia in Barrett's esophagus patients who do not undergo esophagectomyTreatment of mild to moderate Type I Gaucher disease in adults for whom enzyme replacement therapy is not a therapeutic option (e.g., due to Treatment of chronic hepatitis C among previously untreated pediatric patients at least three years of age or older.

Tositumomab and iodine I 131 tositumomab

Treatment of patients with CD20 positive, follicular, non-Hodgkin's lymphoma, with and without transformation, whose disease is Treatment of multiple myeloma patients who have received at least two prior therapies and have demonstrated disease progression on Treatment for patients with Hurler and Hurler-Scheie forms of Mucopolysaccharidosis I (MPS I) and for patients with the Scheie form who

Ceramide trihexosidase/alpha-galactosidase A

For use in patients with Fabry disease to reduce globotriaosylceramide (GL-3) deposition in capillary endothelium of the kidney and certain other cell Treatment of acromegaly in patients who have had an inadequate response to surgery and/or radiation therapy and/or other medical

Expanding the indication to include patients with malignant glioma undergoing primary surgical resection.

Icodextrin 7.5% with Electrolytes Peritoneal Dialysis Solution

Treatment of those patients having end stage renal disease and requiring peritoneal dialysis treatment.

For use as a single daily exchange for the long (8-16 hour) dwell during continuous ambulatory peritoneal dialysis (CAPD) or automated

Treatment of diarrhea caused by Cryptosporidium parvum and Giardia lamblia

Treatment of diarrhea caused by Cryptosporidium parvum and Giardia lambliaFor use in secretin stimulation testing for: Stimulation of pancreatic secretions to facilitate the identification of the ampulla of Vater

Treatment of opioid dependence in patients 16 years of age or older

Suboxone Treatment of opiate addiction in opiate users. 10/27/1994 10/8/2002

oxybate Xyrem Treatment of narcolepsy. 11/7/1994 7/17/2002

rasburicase Elitek 10/11/2000 7/12/2002

treprostinil Remodulin Treatment of pulmonary arterial hypertension. 6/4/1997 5/21/2002

Synthetic porcine secretin 3/7/2000 4/4/2002

Synthetic porcine secretin 6/18/1999 4/4/2002

ibritumomab tiuxetan Zevalin Treatment of B-cell non-Hodgkin's lymphoma. 9/6/1994 2/19/2002

imatinib mesylate Gleevec Treatment of gastrointestinal stromal tumors 11/1/2001 2/1/2002

Nitisinone Orfadin Treatment of tyrosinemia type 1. 5/16/1995 1/18/2002

Bosentan Tracleer Treatment of pulmonary arterial hypertension. 10/6/2000 11/20/2001

Topiramate Topamax Treatment of Lennox-Gastaut syndrome. 11/25/1992 8/28/2001

Zoledronate Zometa, Zabel Treatment of tumor induced hypercalcemia. 8/18/2000 8/20/2001

somatropin [rDNA] Genotropin 12/27/2000 7/25/2001

Imatinib Gleevec Treatment of chronic myelogenous leukemia 1/31/2001 5/10/2001

Buprenorphine in combination with naloxone

Treatment of opioid dependence in patients 16 years of age or older

Treatment of cataplexy associated with narcolepsy.

Treatment of malignancy-associated or chemotherapy-induced hyperuricemia.

Initial management of plasma uric acid levels in pediatric patients with leukemia,lymphoma, and solid tumor malignancies who are receiving anti-

Treatment of pulmonary arterial hypertension.

For use in conjunction with diagnostic procedures for pancreatic disorders to increase pancreatic fluid secretion.

Use in secretin stimulation testing for stimulation of pancreatic secretions, including bicarbonate, to aid in the diagnosis of pancreatic exocrine

For use in the diagnosis of gastrinoma associated with Zollinger-Ellison syndrome.

Use in secretin stimulation testing for stimulation of gastrin secretion to aid in the diagnosis of gastrinomaTreatment of patients with relapsed or refractory low-grade, follicular, or transformed B-cell non-Hodgkin?s lymphoma, including patients with Treatment of patients with Kit (CD117) positive unresectable and/or metastatic malignant gastrointestinal stromal tumors (GIST)Adjunctive therapy to dietary restriction of tyrosine and phenylalanine in the treatment of hereditary tyrosinemia type 1

Treatment of pulmonary arterial hypertension.As adjunctive therapy in patients two years and older with siezures associated with Lennox-Gastaut syndrome.

Treatment of hypercalcemia of malignancy.

Treatment of growth failure in children who were born small for gestational age.

For long-term treatment of growth failure in children born small for gestational age who fail to manifest catch-up growth by two years of age.Treatment of patients with chronic myeloidleukemia (CML) in blast crisis, accelerated phase, or in chronic phase after failure of interferon-alpha therapy

alemtuzumab Campath Treatment of chronic lymphocytic leukemia. 10/20/1997 5/7/2001

Botulinum toxin type A Botox Treatment of cervical dystonia. 8/20/1986 12/21/2000

Botulinum toxin type B Myobloc Treatment of cervical dystonia. 1/16/1992 12/8/2000

Fomepizole Antizole Treatment of methanol or ethylene glycol poisoning. 12/22/1988 12/8/2000

Mitoxantrone Novantrone Treatment of secondary-progressive multiple sclerosis. 8/13/1999 10/13/2000

Mitoxantrone Novantrone Treatment of progressive-relapsing multiple sclerosis. 8/13/1999 10/13/2000

CroFab 1/12/1994 10/2/2000

Arsenic trioxide Trisenox Treatment of acute promyelocytic leukemia. 3/3/1998 9/25/2000

Somatropin [rDNA] Genotropin 7/6/1999 6/20/2000

Follitropin alfa, recombinant Gonal-F 12/21/1998 5/24/2000

Gemtuzumab zogamicin Mylotarg Treatment of CD33-positive acute myeloid leukemia. 11/24/1999 5/17/2000

Epoprostenol Flolan 3/22/1999 4/14/2000

Interferon gamma-1b Actimmune 9/30/1996 2/10/2000

Bexarotene Targretin Treatment of cutaneous T-cell lymphoma. 6/18/1999 12/29/1999

The treatment of patients with B-cell chronic lymphocytic leukemia who have been treated with alkylating agents and who have failed Treatment of cervical dystonia in adults to decrease the severity of abnormal head position and neck pain associated with cervical dystonia.Treatment of patients with cervical dystonia to reduce the severity of abnormal head position and neck pain associated with cervical dystonia.

Use for suspected or confirmed methanol poisoning, either alone or in combination with hemodialysisReducing neurologic disability and/or the frequency of clinical relapses in patients with secondary (chronic) progressive, progressive relapsing, or Reducing neurologic disability and/or the frequency of clinical relapses in patients with secondary (chronic) progressive, progressive relapsing, or

Antivenin, crotalidae polyvalent immune Fab (ovine)

Treatment of envenomations inflicted by North American crotalid snakes.

Carol Clark-Evans direct line (615) 963-4510For induction of remission and consolidation in patients with acute promyelocytic leukemia (APL) who are refractory to, or have relapsed

Treatment of short stature in patients with Prader-Willi syndrome.

Long-term treatment of pediatric patients who have growth failure due to Prader-Willi syndrome (PWS).

For the initiation and re-initiation of spermatogenesis in adult males with reproductive failure due to hypothalamic or pituitary dysfunction, hypogonadotropic hypogonadism. AMENDED indication 6/27/00: For the

For the induction of spermatogenesis in men with primary and secondary hypogonadotropic hypogonadism in whom the cause of infertility is not due Treatment of patients with CD33 positive acute myeloid leukemia in first relapse who are 60 years of age or older and who are not considered

Treatment of secondary pulmonary hypertension due to intrinsic precapillary pulmonary vascular disease.

For the long-term intravenous treatment of pulmonary hypertension associated with the scleroderma spectrum of disease in New York

Delaying time to disease progression in patients with severe, malignant osteopetrosis.

Delaying time to disease progression in patients with severe, malignant osteopetrosis.Treatment of cutaneous manifestations of cutaneous T-cell lymphoma in patients who are refractory to at least one prior

Nitric oxide INOmax 6/22/1993 12/23/1999

Levocarnitine Carnitor 9/6/1988 12/15/1999

Exemestane Aromasin 9/19/1991 10/21/1999

Caffeine Cafcit Treatment of apnea of prematurity. 9/20/1988 9/21/1999

Epirubicin Ellence Treatment of breast cancer. 9/14/1999 9/15/1999

Temozolomide Temodar Treatment of recurrent malignant glioma. 10/5/1998 8/11/1999

Doxorubicin liposome Doxil Treatment of ovarian cancer. 11/4/1998 6/28/1999

Amifostine Ethyol 5/12/1998 6/24/1999

etanercept Enbrel 10/27/1998 5/27/1999

Humate-P 10/16/1992 4/1/1999

Cytarabine liposomal DepoCyt Treatment of neoplastic meningitis. 6/2/1993 4/1/1999

NovoSeven 6/6/1988 3/25/1999

Lidocaine patch 5% Lidoderm Patch 10/24/1995 3/19/1999

denileukin diftitox Ontak Treatment of patients with cutaneous T-cell lymphoma 8/21/1996 2/5/1999

Treatment of persistent pulmonary hypertension in the newborn.

In conjunction with ventilatory support and other appropriate agents, in the treatment of term and near-term (>34 weeks) neonates with hypoxic

Treatment of manifestations of carnitine deficiency in patients with end stage renal disease who require dialysis.

Prevention and treatment of carnitine deficiency in patients with end stage renal disease who are undergoing dialysis.

Treatment of advanced breast cancer in postmenopausal women whose disease has progressed following tamoxifen therapy.

Treatment of advanced breast cancer in postmenopausal women whose disease has progressed following tamoxifen therapy.Short term treatment of apnea of prematurity in infants between 28 and less than 33 weeks gestational age. Component of adjuvant therapy in patients with evidence of axillary node tumor involvement following resection of primary breast cancer.Treatment of adult patients with refractory anaplastic astrocytoma, i.e., patients at first relapse who have experienced disease progression on a Treatment of metastatic carcinoma of the ovary in patients with disease that is refractory to both paclitaxel- and platinium-based chemotherapy

Reduction of the incidence of moderate to severe xerostomia in patients undergoing post-operative radiation treatment for head and neck cancer.

Reduction of the incidence of moderate to severe xerostomia in patients undergoing post-operative radiation treatment for head and neck Reduction in signs and symptoms of moderately to

severely active polyarticular-course juvenile rheumatoid arthritis in patients who have had an inadequate response to one or more disease-modifying anti-

Reduction in signs and symptoms of moderately to severely active polyarticular-course juvenile rheumatoid arthritis in patients who

Antihemophilic factor/von Willebrand factor complex (human), dried, pasteurized

Treatment of patients with von Willebrand's disease

(1) In adult patients for treatment and prevention of bleeding in hemophilia A (classic hemophilia) and (2) in adult and pediatric patients for treatment of

Intrathecal treatment of lymphomatous meningitis.

Coagulation factor VIIa (recombinant)

Treatment of bleeding episodes in hemophilia A or B patients with inhibitors to Factor VIII or Factor IX.

Treatment of bleeding episodes in hemophilia A or B patients with inhibitors to Factor VIII or Factor IX.

For relief of allodynia (painful hypersensitivity), and chronic pain in postherpetic neuralgia.

Treatment of patients with persistent or recurrent cutaneous T-cell lymphoma whose malignant cells express the CD25 component of the

Busulfan Busulfex 7/28/1994 2/4/1999

Alitretinoin Panretin Treatment of AIDS-related Kaposi's sarcoma. 3/24/1998 2/2/1999

Atovaquone Mepron 8/14/1991 1/5/1999

Modafinil Provigil 3/15/1993 12/24/1998

CytoGam 8/3/1987 12/4/1998

Thyrotropin alpha Thyrogen As an adjunct in the diagnosis of thyroid cancer. 2/24/1992 11/30/1998

Octreotide Sandostatin LAR 8/24/1998 11/25/1998

Octreotide Sandostatin LAR Treatment of acromegaly. 8/24/1998 11/25/1998

Octreotide Sandostatin LAR 8/24/1998 11/25/1998

Valrubicin Valstar Treatment of carcinoma in situ of the urinary bladder. 5/23/1994 9/25/1998

Infliximab Remicade 11/14/1995 8/24/1998

Lamotrigine Lamictal Treatment of Lennox-Gastaut syndrome. 8/23/1995 8/24/1998

Thalidomide Thalomid Treatment of erythema nodosum leprosum. 7/26/1995 7/16/1998

As preparative therapy in the treatment of malignancies with bone marrow transplantation.

For use in combination with cyclophosphamide as a conditioning regimen prior to allogeneic hematopoietic progenitor cell

Topical treatment of cutaneous lesions in patients with AIDS-related Kaposi's sarcoma.

Prevention of Pneumocystis carinii pneumonia (PCP) in high-risk, HIV-infected patients defined by a history of one or more episodes of PCP and/or a peripheral CD4+ (T4 helper/inducer) lymphocyte count less than or equal

Prevention of PCP in patients who are intolerant to trimethoprim-sulfamethoxazole.

Treatment of excessive daytime sleepiness in narcolepsy.

Improve wakefulness in patients with excessive daytime sleepiness associated with narcolepsy.

Cytomegalovirus immune globulin (human)

Prevention or attenuation of primary cytomegalovirus disease in immunosuppressed recipients of organ transplants.

#1) Attenuation of primary CMV disease associated with kidney transplant recipients who are seronegative for CMV and who receive a kidney from a CMV seropositve donor; #2) Prophylaxis of CMV disease associated transplantation of kidney (all other), lung,As an adjunctive diagnostic tool for serum thyroglobulin (Tg) testing with or without radioiodine imaging in the follow-up of patients with thyroid

Treatment of severe diarrhea and flushing associated with malignant carcinoid tumors.

Supression of severe diarrhea and flushing associated with malignant carcinoid syndrome.

Reduction of growth hormone and IGF-1 (somatomedin C) in acromegaly.

Treatment of diarrhea associated with vasoactive intestinal peptide tumors (VIPoma).

Treatment of profuse watery diarrhea associated with VIPoma.For intravesical therapy of BCG-refractory carcinoma in situ of the urinary bladder in patients for whom immediate cystectomy would be

Treatment of moderately to severely active Crohn's disease for the reduction of the signs and symptoms, in patients who have an inadequate response to conventional therapy; and treatment of patients with

Treatment of moderately to severely active Crohn's disease for the reduction of the signs and symptoms, in patients who have an inadequate Adjunctive treatment of Lennox-Gastaut syndrome in pediatric and adult patients.Acute treatment of the cutaneous manifestations of moderate to severe erythema nodosum leprosum (ENL) and as maintenance therapy for

Rifapentine Priftin Treatment of pulmonary tuberculosis. 6/9/1995 6/22/1998

Mafenide acetate solution Sulfamylon solution 7/18/1990 6/5/1998

Basiliximab Simulect 12/12/1997 5/12/1998

Sacrosidase Sucraid Treatment of congenital sucrase-isomaltase deficiency. 12/10/1993 4/9/1998

Filgrastim Neupogen 11/7/1996 4/2/1998

Lepirudin Refluden 2/13/1997 3/6/1998

Hydroxyurea Droxia 10/1/1990 2/25/1998

Pilocarpine HCl Salagen 2/28/1992 2/11/1998

Aldesleukin Proleukin Treatment of metastatic melanoma. 9/10/1996 1/9/1998

Sterile talc powder Sclerosol Intrapleural Treatment of malignant pleural effusion. 9/18/1995 12/24/1997

Tobramycin for inhalation TOBI 10/13/1994 12/22/1997

Somatropin for injection Nutropin 11/18/1996 12/15/1997

Daclizumab Zenapax Prevention of acute renal allograft rejection. 3/5/1993 12/10/1997

Ursodiol URSO Treatment of patients with primary biliary cirrhosis. 6/20/1991 12/10/1997

For use as an adjunctive topical antimicrobial agent to control bacterial infection when used under moist dressings over meshed autografts on excised burn wounds.

Prophylaxis of solid organ rejection.

Prophylaxis of acute organ rejection in patients receiving renal transplantation when used as part of an immunosuppressive regimen that

Oral replacement therapy of the genetically determined sucrase deficiency, which is part of congenital sucrease-isomaltase deficiency.

Reduction in the duration of neutropenia, fever, antibiotic use, and hospitalization, following induction and consolidation treatment for acute myeloid leukemia.

Reducing the time to neutrophil recovery and the duration of fever, following induction or consolidation chemotherapy treatment of adults with

Treatment of heparin-associated thrombocytopenia type II.

For anticoagulation in patients with heparin-induced thrombocytopenia and associated thromboembolic disease in order to prevent further

Treatment of patients with sickle cell anemia as shown by the presence of hemoglobin S.

To reduce the frequency of painful crises and to reduce the need for blood transfusions in adult patients with sickle cell anemia with recurrent

Treatment of xerostomia and keratoconjunctivitis sicca in Sjogren's syndrome patients.

Treatment of dry mouth in patients with Sjogren's syndrome.

Treatment of adults with metastatic melanoma.

Prevention of recurrence of malignant pleural effusions in symptomatic patients.

Treatment of bronchopulmonary infections of Pseudomonas aeruginosa in cystic fibrosis patients.

Management of cystic fibrosis patients with P.aeruginosa.

As replacement therapy for growth hormone deficiency in adults after epiphyseal closure.

Prophylaxis of acute organ rejection in patients receiving renal transplants, to be used as a part of an immunosuppressive regimen that

Fomepizole Antizole Treatment of methanol or ethylene glycol poisoning. 12/22/1988 12/4/1997

rituximab Rituxan Treatment of non-Hodgkin's B-cell lymphoma. 6/13/1994 11/26/1997

Oprelvekin Neumega 12/17/1996 11/25/1997

Somatropin Genotropin Treatment of adults with growth hormone deficiency. 9/6/1994 10/31/1997

Sermorelin acetate Geref 9/14/1988 9/26/1997

Liposomal amphotericin B AmBisome Treatment of visceral leishmaniasis. Treatment of visceral leishmaniasis. 12/6/1996 8/11/1997

Liposomal amphotericin B AmBisome Treatment of cryptococcal meningitis. 12/10/1996 8/11/1997

Paclitaxel Taxol Treatment of AIDS-related Kaposi's sarcoma. 3/25/1997 8/4/1997

2/25/1992 7/29/1997

Toremifene Fareston 9/19/1991 5/29/1997

Anagrelide Agrylin Treatment of essential thrombocythemia. 1/27/1988 3/14/1997

BeneFix Treatment of hemophilia B. 10/3/1994 2/11/1997

Zinc acetate Galzin Treatment of Wilson's disease. 11/6/1985 1/28/1997

Somatropin Humatrope 5/8/1990 12/30/1996

Somatropin for injection Nutropin 3/23/1989 12/30/1996

As an antidote to ethylene glycol (antifreeze) poisoning, or for use in suspected ethylene glycol ingestion.

Prevention of severe chemotherapy-induced thrombocytopenia.

Treatment of idiopathic or organic growth hormone deficiency in children with growth failure.

Treatment of disseminated cryptococcosis including meningitis.

For the second line treatment of AIDS-related Kaposi's sarcoma.

Diazepam viscous solution for rectal administration

For the management of selected, refractory, patients with epilepsy, on stable regimens of antiepileptic drugs (AEDs), who require intermittent use of diazepam to control bouts of increased seizure activity.

Hormonal therapy of metastatic carcinoma of the breast.

Treatment of metastatic breast cancer in postmenopausal women with estrogen positive or receptor unknown tumors.Treatment of patients with essential thrombocythemia to reduce the elevated platelet count and the risk of thrombosis and to ameliorate

Coagulation Factor IX (recombinant)

For the control and prevention of hemorrhagic episodes in patients with hemophilia B (congenital factor IX deficiency and Christmas disease),

For maintenance treatment of patients with Wilson's disease who have been initially treated with a chelating agent.

Treatment of short stature associated with Turner syndrome.

Treatment of short stature associated with Turner syndrome in patients whose epiphyses are not closed.

Treatment of short stature associated with Turner's syndrome.

Treatment of growth failure associated with Turner syndrome.

Glatiramer acetate Copaxone Treatment of multiple sclerosis. 11/9/1987 12/20/1996

Mitoxantrone Novantrone Treatment of hormone refractory prostate cancer. 8/21/1996 11/13/1996

Betaine Cystadane Treatment of homocystinuria. 5/16/1994 10/25/1996

Amphotericin B lipid complex Abelcet Treatment of invasive fungal infections. 12/5/1991 10/18/1996

Clonidine Duraclon 1/24/1989 10/2/1996

Elliotts B Solution 8/24/1994 9/27/1996

Pentosan polysulfate sodium Elmiron Treatment of interstitial cystitis. 8/7/1985 9/26/1996

polifeprosan 20 with carmustine Gliadel Treatment of malignant glioma. 12/13/1989 9/23/1996

Midodrine HCl Amatine 12/5/1996 9/6/1996

Somatropin for injection Serostim Treatment of AIDS-associated catabolism/weight loss. 11/15/1991 8/23/1996

Fosphenytoin Cerebyx 6/4/1991 8/5/1996

Albendazole Albenza 1/18/1996 6/11/1996

Albendazole Albenza 1/17/1996 6/11/1996

Corticorelin ovine triflutate Acthrel 11/24/1989 5/23/1996

Ofloxacin Ocuflox Ophthalmic STreatment of bacterial corneal ulcers. Treatment of bacterial corneal ulcers. 4/18/1991 5/22/1996

For reduction of the frequency of relapses in patients with relapsing-remitting multiple sclerosis.In combination with corticosteroids as initial chemotherapy for the treatment of patients with pain related to advanced hormone-refractory prostate

Treatment of homocystinuria to decrease elevated homocysteine blood levels.Treatment of invasive fungal infections in patients who are refractory to or intolerant of conventional amphotericin B therapy.For continous epidural administration as adjunctive

therapy with intraspinal opiates for the treatment of pain in cancer patients tolerant to, or unresponsive to, intraspinal opiates.

In combination with opiates for the treatment of severe pain in cancer patients that is not adequately relieved by opioid analgesics alone.

Buffered intrathecal electrolyte/dextrose injection

For use as a diluent in the intrathecal administration of methotrexate and cytarabine for the prevention or treatment meningeal leukemia and lymphocytic lymphoma.

For the intrathecal administration of methotrexate and cytarabine for the prevention or treatment of meningeal leukemia and lymphocytic lymphoma.

Relief of bladder pain or discomfort associated with interstitial cystitis.As an adjunct to surgery to prolong survival in patients with recurrent glioblastoma multiforme for whom surgical resection is indicated

Treatment of patients with symptomatic orthostatic hypotension.

Treatment of symptomatic orthostatic hypotension.

Treatment of AIDS wasting or cachexia.

For the acute treatment of patients with status epilepticus of the grand mal type.

For the control of generalized convulsive status epilepticus.

Treatment of neurocysticercosis due to Taenia solium as: 1) chemotherapy of parenchymal, subarachnoidal and racemose (cysts in spinal fluid) neurocysticercosis in symptomatic cases and 2) prophylaxis of epilepsy

Treatment of parenchymal neurocysticercosis due to active lesions caused by larval forms of the pork tapeworm, Taenia solium.

Treatment of hydatid disease (cystic echinococcosis due to E. granulosus larvae or alveolar echinococcosis due to E. multilocularis larvae).

Treatment of cystic hydatid disease of the liver, lung, and peritoneum, caused by the larval form of the dog tapeworm, Echinococcus granulosus.

For use in differentiating pituitary and ectopic production of ACTH in patients with ACTH-dependent Cushings syndrome.

To differentiate between pituitary and ectopic production of ACTH in patients with ACTH-dependent Cushing's syndrome.

Allopurinol sodium Aloprim for Injection 10/16/1992 5/17/1996

Interferon beta-1a Avonex Treatment of multiple sclerosis. 12/16/1991 5/17/1996

sodium phenylbutyrate Buphenyl 11/22/1993 4/30/1996

DaunoXome 5/14/1993 4/8/1996

Ganciclovir intravitreal implant Vitrasert Implant Treatment of cytomegalovirus retinitis. 6/7/1995 3/4/1996

Bleomycin sulfate Blenoxane Treatment of malignant pleural effusion. 9/17/1993 2/20/1996

Respigam 9/27/1990 1/18/1996

Filgrastim Neupogen 7/17/1995 12/28/1995

Porfimer sodium Photofrin 6/6/1989 12/27/1995

Riluzole Rilutek Treatment of amyotrophic lateral sclerosis. 3/16/1993 12/12/1995

Amifostine Ethyol 5/30/1990 12/8/1995

Tretinoin Vesanoid Treatment of acute promyelocytic leukemia. 10/24/1990 11/22/1995

Interferon alfa-2a Roferon A Treatment of chronic myelogenous leukemia. 6/6/1989 10/19/1995

Epoprostenol Flolan Treatment of primary pulmonary hypertension. 9/25/1985 9/20/1995

Management of patients with leukemia, lymphoma, and solid tumor malignancies who are receiving cancer therapy which causes elevations of serum and urinary uric acid levels and who cannot tolerate oral therapy.

Management of patients with leukemia, lymphoma, and solid tumor malignancies who are receiving cancer therapy which causes Treatment of relapsing forms of multiple sclerosis to slow the accumulation of physical disability and decrease the frequency of clinical

Treatment of urea cycle disorders: carbamylphosphate synthetase deficiency, ornithine transcarbamylase deficiency, and arginiosuccinic acid synthetase deficiency.

Adjunctive therapy in the chronic managment of patients with urea cycle disorders involving deficiencies of carbamylphosphate synthetase,

Daunorubicin citrate liposome injection

Treatment of patients with advanced HIV-associated Kaposi's sarcoma.

First line cytotoxic therapy for advanced, HIV related Kaposi's sarcoma.

Treatment of CMV retinitis in patients with acquired immunodeficiency syndrome.

Treatment of malignant pleural effusion.

Respiratory syncytial virus immune globulin (Human)

Prophylaxis of respiratory syncytial virus lower respiratory tract infections in infants and young children at high risk of RSV disease.

For the prevention of serious lower respiratory tract infections caused by RSV in children less than 24 months of age with bronchopulmonary

For use in the mobilization of peripheral blood progenitor cells for collection in patients who will receive myeloablative or myelosuppressive chemotherapy.

For use in the mobilization of hematopoietic progenitor cells into the peripheral blood collection by leukapheresis.

For the photodynamic therapy of patients with primary or recurrent obstructing (either partially or completely) esophageal carcinoma.

Photodynamic therapy with PHOTOFRIN for the palliation of patients with completely obstructing esophageal cancer, or of patients with Treatment of patients with amyotrophic lateral sclerosis. Riluzole extends survival and/or time to tracheostomy.

For use as a chemoprotective agent for cisplatin in the treatment of advanced ovarian carcinoma.

To reduce the cumulative renal toxicity associated with repeated administration of cisplatin in patients with advanced ovarian cancer.Induction of remission in patients with acute promyelocytic leukemia who are refractory to or unable to tolerate anthracycline based cytotoxic

Treatment of chronic myelogenous leukemia.

Long-term intravenous treatment of primary pulmonary hypertension in NYHA Class III and Class IV patients.

Sargramostim Leukine 3/6/1995 9/15/1995

Amiodarone HCl Cordarone 3/16/1994 8/3/1995

Dexrazoxane Zinecard 12/17/1991 5/26/1995

WinRho SD Treatment of immune thrombocytopenic purpura. 11/9/1993 3/24/1995

Filgrastim Neupogen 11/7/1990 12/19/1994

Cysteamine Cystagon Treatment of nephropathic cystinosis. 1/25/1991 8/15/1994

Sulfadiazine 3/14/1994 7/29/1994

Aminosalicylic acid Paser Granules Treatment of tuberculosis infections Treatment of tuberculosis 2/19/1992 6/30/1994

Filgrastim Neupogen 10/1/1990 6/15/1994

Rifampin, isoniazid, pyrazinamide Rifater For the short-course treatment of tuberculosis. 9/12/1985 5/31/1994

Imiglucerase Cerezyme 11/5/1991 5/23/1994

Pilocarpine Salagen 9/24/1990 3/22/1994

Desmopressin acetate 1/22/1991 3/7/1994

Pegaspargase Oncaspar Treatment of acute lymphocytic leukemia. 10/20/1989 2/1/1994

To reduce neutropenia and leukopenia and decrease the incidence of death due to infection in patients with acute myelogenous leukemia.

Following induction chemotherapy in older adult patients with acute myelogenous leukemia to shorten time to neutrophil recovery and to

For the acute treatment and prophylaxis of life-threatening ventricular tachycardia or ventricular fibrillation.

For initiation of treatment and prophylaxis of frequently recurring ventricular fibrillation and hemodynamically unstable ventricular

For the prevention of cardiomyopathy associated with doxorubicin administration.

Cardiomyopathy associated with doxorubicin administration in women with metastatic breast cancer who have received a cumulative dose of

Rho (D) immune globulin intravenous (human)

Treatment of adults and children with chronic and acute immune thrombocytopenic purpura.

Treatment of patients with severe chronic neutropenia (absolute neutrophil count less than 500/mm3).

Treatment of patients with severe chronic neutropenia.

Treatment of nephropathic cystinosis in adults and children.

For use in combination with pyrimethamine for the treatment of Toxoplasma gondiiencephalitis in patients with and without AIDS.

Toxoplasmosis, as adjunctive with pyrimethamine

Treatment of neutropenia associated with bone marrow transplants.

Reduce the duration of neutropenia and neutropenia sequelae in patients with non-myeloid malignancies undergoing ablative chemotherapy

Short-course treatment of tuberculosis.

Replacement therapy in patients with types I, II, and III Gaucher's disease.

Enzyme replacement therapy in patients with type I Gaucher's disease.

Treatment of xerostomia induced by radiation therapy for head and neck cancer.

Treatment of symptoms of xerostomia from salivary gland hypofunction caused by radiotherapy for cancer of the head and neck.

Treatment of mild hemophilia A and von Willebrand's disease.

Treatment of patients with hemophilia A or von Willebrand's disease (type I) whose factor VIII coagulant activity level is greater than 5%.Combination chemotherapy for the treatment of patients with acute lymphoblastic leukemia who are hypersensitive to native forms of L-

Dornase alfa Pulmozyme 1/16/1991 12/30/1993

Aprotinin Trasylol 11/17/1993 12/29/1993

Gamimune N 2/18/1993 12/27/1993

Trimetrexate glucuronate Neutrexin 5/15/1986 12/17/1993

Somatropin for injection Nutropin 8/4/1989 11/17/1993

Lodoxamide tromethamine Alomide Ophthalmic STreatment of vernal keratoconjunctivitis. 10/16/1991 9/23/1993

Megestrol acetate Megace 4/13/1988 9/10/1993

Felbamate Felbatol Treatment of Lennox-Gastaut syndrome. 1/24/1989 7/29/1993

Interferon beta-1b Betaseron Treatment of multiple sclerosis. 11/17/1988 7/23/1993

Orlaam 1/24/1985 7/9/1993

Leuprolide acetate Lupron Injection Treatment of central precocious puberty. 7/25/1988 4/16/1993

Cladribine Leustatin Injection Treatment of hairy cell leukemia. 11/15/1990 2/26/1993

Kogenate 9/25/1989 2/25/1993

Satumomab pendetide Oncoscint CR/OV Detection of ovarian carcinoma. 9/25/1989 12/29/1992

Rifabutin Mycobutin 12/18/1989 12/23/1992

To reduce mucous viscosity and enable the clearance of airway secretions in patients with cystic fibrosis.

In conjunction with standard therapies in the management of cystic fibrosis patients to reduce the frequency of respiratory infections requiring

For prophylactic use to reduce perioperative blood loss and the homologous blood transfusion requirement in patients undergoing cardiopulmonary bypass surgery in the course of repeat coronary artery bypass graft

Immune globulin intravenous, human

Infection prophylaxis in pediatric patients affected with the human immunodeficiency virus.

For prophylaxis of children with clinical or immunologic evidence of human immunodeficiency virus to decrease the frequency of serious and

Treatment of Pneumocystis carinii pneumonia in AIDS patients.

Concurrent leucovorin administration as an alternative therapy for the treatment of moderate to severe PCP in immunocompromised patients who

Treatment of growth retardation associated with chronic renal failure.

Treatment of children with growth failure associated with chronic renal insufficency.Treatment of ocular disorders referred to by the terms vernal keratoconjunctivitis, vernal conjunctivitis, vernal keratitis.Treatment of patients with anorexia, cachexia, or

significant weight loss (=/>10% of baseline body weight) and confirmed diagnosis of AIDS.

Treatment of anorexia, cachexia, or an unexplained significant weight loss in patients with a diagnosis of acquired immune deficiency As adjunctive therapy in the treatment of partial and generalized seizures associated with the Lennox-Gastaut syndrome in children.In ambulatory patients with relapsing-remitting multiple sclerosis to reduce the frequency of clinical exacerbations.

Levomethadyl acetate hydrochloride

Treatment of heroin addicts suitable for maintenance on opiate agonists.

For the management of opiate dependence.

Treatment of children with central precocious puberty.

Antihemophilic factor (recombinant)

Prophylaxis and treatment of bleeding in individuals with hemophilia A or for prophylaxis when surgery is required in individuals with hemophilia A.

Treatment and prophylaxis of bleeding in patients with hemophilia A (not von Willebrand's disease)For determining the extent and location of extraphepatic malignant disease in patients with known colorectal and ovarian cancer.Prevention of disseminated Mycobacterium avium

complex disease in patients with advanced HIV infection.

Prevention of disseminated Mycobacterium avium complex disease in patients with advanced HIV infections.

Dronabinol Marinol 1/15/1991 12/22/1992

Levocarnitine Carnitor 7/26/1984 12/16/1992

Atovaquone Mepron 9/10/1990 11/25/1992

Melphalan Alkeran For Injection 2/24/1992 11/18/1992

Sotalol HCl Betapace 9/23/1988 10/30/1992

Coagulation factor IX Mononine 6/27/1989 8/20/1992

Halofantrine Halfan 11/4/1991 7/24/1992

Teniposide Vumon for injection 11/1/1984 7/14/1992

Baclofen Lioresal Intrathecal 11/10/1987 6/25/1992

Zalcitabine Hivid Treatment of AIDS. 6/28/1988 6/19/1992

Aldesleukin Proleukin Treatment of metastatic renal cell carcinoma. 9/14/1988 5/5/1992

Nafarelin acetate Synarel Nasal Solutio Treatment of central precocious puberty. 7/20/1988 2/26/1992

Liothyronine sodium injection Triostat Treatment of myxedema coma/precoma. 7/30/1990 12/31/1991

For the stimulation of appetite and prevention of weight loss in patients with a confirmed diagnosis of AIDS.

Treatment of anorexia associated with weight loss in patients with AIDS.

Treatment of primary and secondary carnitine deficiency of genetic origin.

Treatment of primary systemic carnitine deficiency. (approved 12/27/85) Treatment of secondary carnitine deficiency. (approved 12/16/92)

Treatment of AIDS associated Pneumocystis Carinii Pneumonia.

For the acute oral treatment of mild to moderate Pneumocystis carinii pneumonia in patients who are intolerant to trimethoprim-

Treatment of patients with multiple myeloma for whom oral therapy is inappropriate.

For the palliative treatment of patients with multiple myeloma for whom oral melphalan is not appropriate.

Treatment of life-threatening ventricular tachyarrhythmias.

Replacement treatment and prophylaxis of the hemorrhagic complications of hemophilia B.

Prevention and control of bleeding in factor IX deficiency, also known as hemophilia B or Christmas disease.

Treatment of mild to moderate acute malaria caused by susceptible strains of P. falciparum and P. vivax.

Treatment of adults who can tolerate oral medication and who have mild to moderate malaria caused by Plasmodium falciparum or

Treatment of refractory childhood acute lymphocytic leukemia.

Induction therapy in patients with refractory childhood acute lymphoblastic leukemia when used in combination with other approved

Treatment of intractable spasticity caused by spinal cord injury, multiple sclerosis, and other spinal diseases (including spinal ischemia, spinal tumor, transverse myelitis, cervical spondylosis, and degenerative

Management of severe spasticity of spinal cord origin in patients who are unresponsive to oral baclofen therapy or experience intolerable CNS side Combination therapy with zidovudine is indicated for the treatment of adult patients with advanced HIV infection (CD4 count < 300) who have

Treatment of adults (>18 years old) with metastatic renal cell carcinoma.Treatment of central precocious puberty (gonadotropin-dependent precocious puberty) in children of both sexes.

Treatment of myxedema coma/precoma.

Antithrombin III (human) Thrombate III 11/26/1984 12/30/1991

Histrelin acetate Supprelin Injection Treatment of central precocious puberty. 8/10/1988 12/24/1991

Leucovorin Leucovorin calcium 12/8/1986 12/12/1991

Pentostatin for injection Nipent Treatment of hairy cell leukemia. 9/10/1987 10/11/1991

Infumorph 7/12/1990 7/19/1991

Beractant Survanta intratrachea Prevention of neonatal respiratory distress syndrome. 2/5/1986 7/1/1991

Beractant Survanta intratrachea Treatment of neonatal respiratory distress syndrome. 2/5/1986 7/1/1991

Fludarabine phosphate Fludara 4/18/1989 4/18/1991

Alglucerase injection Ceredase 3/11/1985 4/5/1991

Sargramostim Leukine 5/3/1990 3/5/1991

Gallium nitrate injection Ganite Treatment of hypercalcemia of malignancy. 12/5/1988 1/17/1991

Coagulation Factor IX (human) AlphaNine 7/5/1990 12/31/1990

Epoetin alfa Epogen 7/1/1991 12/31/1990

Altretamine Hexalen Treatment of advanced adenocarcinoma of the ovary. 2/9/1984 12/26/1990

Interferon gamma 1-b Actimmune Treatment of chronic granulomatous disease. 9/30/1988 12/20/1990

Calcium acetate Phos-Lo 12/22/1988 12/10/1990

For replacement therapy in congenital deficiency of AT-III for prevention and treatment of thrombosis and pulmonary emboli.

Treatment of central precocious puberty.

For use in combination with 5-fluorouracil for the treatment of metastatic colorectal cancer.

For use in combination with 5-fluorouracil to prolong survival in the palliative treatment of patients with advanced colorectal cancer.Single agent treatment for adult patients with alpha-interferon-refractory hairy cell leukemia.

Morphine sulfate concentrate (preservative free)

For use in microinfusion devices for intraspinal administration in the treatment of intractable chronic pain.

For intrathecal or epidural infusion in the treatment of tractable chronic pain. It was developed for use in continuous microinfusion devices and may require dilution before use as Prevention of RDS (hyaline membrane disease) in premature infants less than 1250 grams birthweight or with evidence of Treatment of ("rescue") of premature infants with RDS confirmed by x-ray and requiring mechanical ventilation.

Treatment of chronic lymphocytic leukemia (CLL), including refractory CLL.

For replacement therapy in patients with Gaucher's disease type I.

Long-term enzyme replacement therapy for children, adolescents and adult patients with a confirmed diagnosis of Type I Gaucher disease

Treatment of neutropenia associated with bone marrow transplant, for the treatment of graft failure and delay of engraftment, and for the promotion of early engraftment.

For use as replacement therapy in patients with hemophilia B for the prevention and control of bleeding episodes, and during surgery to correct defective hemostasis.

Treatment of anemia associated with HIV infection or HIV treatment.

Treatment of AZT-induced anemia in HIV infected patients.Single agent palliative treatment of patients with persistent or recurrent ovarian cancer following first-line therapy with a cisplatin and/or

Treatment of hyperphosphatemia in end stage renal failure.

Eflornithine HCl Ornidyl 4/23/1986 11/28/1990

Renacidin Irrigation 8/28/1989 10/2/1990

Idarubicin HCl for injection Idamycin 7/25/1988 9/27/1990

Exosurf Neonatal for 10/20/1989 8/2/1990

Exosurf Neonatal for 10/20/1989 8/2/1990

Iobenguane Sulfate I 131 11/14/1984 3/21/1990

Pegademase bovine Adagen 5/29/1984 3/21/1990

Botulinum toxin type A Botox 3/22/1984 12/29/1989

Botulinum toxin type A Botox 3/22/1984 12/29/1989

Cromolyn sodium Gastrocrom Treatment of mastocytosis. 3/8/1984 12/22/1989

Antithrombin III (human) ATnativ 2/8/1985 12/13/1989

Gonadorelin acetate Lutrepulse 4/22/1987 10/10/1989

Ganciclovir sodium Cytovene 10/31/1985 6/23/1989

Treatment of Trypanosoma brucei gambiense infection (sleeping sickness).

Citric acid, glucono-delta-lactone and magnesium carbonate

Treatment of renal and bladder calculi of the apatite or struvite variety.

Treatment of acute myelogenous leukemia, also referred to as acute nonlymphocytic leukemia.

Colfosceril palmitate, cetyl alcohol, tyloxapol

Treatment of established hyaline membrane disease at all gestational ages.

Colfosceril palmitate, cetyl alcohol, tyloxapol

Prevention of hyaline membrane disease, also known as respiratory distress syndrome, in infants born at 32 weeks gestation or less.

For use as a diagnostic adjunct in patients with pheochromocytoma.

Adjunctive diagnostic agent in the localization of primary or metastatic pheochromocytomas.

For enzyme replacement therapy for ADA deficiency in patients with severe combined immunodeficiency.

Treatment of strabismus associated with dystonia in adults (patients 12 years of age and above).

Treatment of blepharospasm associated with dystonia in adults (patients 12 years of age and above).

For the treatment of patients with hereditary antithrombin III deficiency in connection with surgical or obstetrical procedures or when they suffer from thromboembolism.For induction of ovulation in women with hypothalamic amenorrhea due to a deficiency or absence in the quantity or pulse pattern of endogenous GnRH secretion.

Treatment of cytomegalovirus retinitis in immunocompromised patients with AIDS.

Pentamidine isethionate Nebupent 1/12/1988 6/15/1989

Selegiline HCl Eldepryl 11/7/1984 6/5/1989

Epoetin alfa Epogen 4/10/1986 6/1/1989

Rifampin Rifadin I.V. 12/9/1985 5/25/1989

Mefloquine HCl Lariam 4/13/1988 5/2/1989

Mefloquine HCl Lariam 4/13/1988 5/2/1989

Ifosfamide Ifex Treatment of testicular cancer. 1/20/1987 12/30/1988

Mesna Mesnex 11/14/1985 12/30/1988

Ethanolamine oleate Ethamolin 3/22/1984 12/22/1988

Succimer Chemet capsules Treatment of lead poisoning in children. 5/9/1984 12/22/1988

Metronidazole (topical) Metrogel Treatment of acne rosacea. 10/22/1987 11/22/1988

Interferon alfa-2a (recombinant) Roferon-A Treatment of AIDS related Kaposi's sarcoma. 12/14/1987 11/21/1988

Interferon alfa-2b (recombinant) Intron A Treatment of AIDS-related Kaposi's sarcoma. 6/24/1987 11/21/1988

Leucovorin Leucovorin calcium 8/17/1988 8/31/1988

Prevention of Pneumocystis carinii pneumonia in patients at high risk of developing this disease.As an adjuvant to levodopa and carbidopa treatment of idiopathic Parkinson's disease (paralysis agitans), postencephalitic Parkinsonism, and symptomatic Parkinsonism.

Treatment of anemia associated with end stage renal disease.

For antituberculosis treatment where use of the oral form of the drug is not feasible.

Prophylaxis of Plasmodium falciparum malaria which is resistant to other available drugs.

Treatment of acute malaria due to Plasmodium falciparum and Plasmodium vivax.

In combination with certain other approved antineoplastic agents, for third line chemotherapy in the treatment of germ cell testicular

For use as a prophylactic agent in reducing the incidence of ifosfamide-induced hemorrhagic cystitis.

Treatment of patients with esophageal varices that have recently bled, to prevent rebleeding.

Treatment of selected patients with AIDS-related Kaposi's sarcoma.

For rescue use after high dose methotrexate therapy in the treatment of osteosarcoma.

Tiopronin Thiola 1/17/1986 8/11/1988

Methotrexate sodium Methotrexate Treatment of osteogenic sarcoma. 10/21/1985 4/7/1988

Benzoate and phenylacetate Ucephan 1/21/1986 12/23/1987

Mitoxantrone HCl Novantrone 7/13/1987 12/23/1987

Teriparatide Parathar 1/9/1987 12/23/1987

Prolastin 12/7/1984 12/2/1987

Pentastarch Pentaspan 8/28/1985 5/19/1987

Etidronate disodium Didronel 3/21/1986 4/21/1987

Zidovudine Retrovir Treatment of AIDS. 7/17/1985 3/19/1987

Zidovudine Retrovir Treatment of AIDS related complex. 7/17/1985 3/19/1987

Somatropin for injection Humatrope 6/12/1986 3/8/1987

Tranexamic acid Cyklokapron 10/29/1985 12/30/1986

Clofazimine Lamprene 6/11/1984 12/15/1986

Calcitonin-human for injection Cibacalcin 1/20/1987 10/31/1986

Urofollitropin Metrodin 11/25/1987 9/18/1986

Prevention of cystine nephrolithiasis in patients with homozygous cystinuria.

For the use of high dose methotrexate with leucovorin rescue in patients with non-metastatic osteosarcoma who have undergone surgical resection or

For adjunctive therapy in the prevention and treatment of hyperammonemia in patients with urea cycle enzymopathy due to carbamylphosphate synthetase, ornithine, transcarbamylase, or argininosuccinate

Treatment of acute myelogenous leukemia, also referred to as acute nonlymphocytic leukemia.Diagnostic agent to assist in establishing the diagnosis in patients presenting with clinical and laboratory evidence of hypocalcemia due to either hypoparathyroidism or pseudohypoparathyroidism.

Alpha1-proteinase inhibitor (human)

For replacement therapy in the alpha-1-proteinase inhibitor congenital deficiency state.

For chronic replacement therapy of individuals having congenital deficiency of alpha1- proteinase inhibitor with clinically demonstrable As an adjunct in leukapheresis to improve the

harvesting and increase the yield of leukocytes by centrifugal means.Treatment of hypercalcemia of malignancy inadequately managed by dietary modification and/or oral hydration.

For the long-term treatment of children who have growth failure due to inadequate secretion of normal endogenous growth hormone.Treatment of patients with congenital coagulopathies who are undergoing surgical procedures (e.g. dental extractions).

Treatment of lepromatous leprosy, including dapsone-resistant lepromatous leprosy and lepromatous leprosy complicated by erythema nodosum leprosum.

Treatment of symptomatic Paget's disease (osteitis deformans).For induction of ovulation in patients with polycystic ovarian disease who have an elevated LH/FSH ratio and who have failed to respond to adequate clomiphene citrate therapy.

Digoxin immune FAB (Ovine) Digibind 11/1/1984 4/22/1986

Levocarnitine Carnitor Treatment of genetic carnitine deficiency. 2/28/1984 4/10/1986

Trientine HCl Syprine 12/24/1984 11/8/1985

Monooctanoin Moctanin 5/30/1984 10/31/1985

Somatrem for injection Protropin 12/9/1985 10/17/1985

Somatropin Nutropin 3/6/1987 10/17/1985

Potassium citrate Urocit-K 11/1/1984 8/30/1985

Potassium citrate Urocit-K 11/1/1984 8/30/1985

Potassium citrate Urocit-K Prevention of uric acid nephrolithiasis. 11/1/1984 8/30/1985

Naltrexone HCl Trexan 3/11/1985 11/30/1984

Pentamidine isethionate Pentam 300 Treatment of Pneumocystis carinii pneumonia. 2/28/1984 10/16/1984

Opticrom 4% ophthalmTreatment of vernal keratoconjunctivitis. 7/24/1985 10/3/1984

Chenodiol Chenix 9/21/1984 7/28/1983

Hemin Panhematin 3/16/1984 7/20/1983

Treatment of potentially life threatening digitalis intoxication in patients who are refractory to management by conventional therapy.

Treatment of patients with Wilson's disease who are intolerant, or inadequately responsive to penicillamine.

For dissolution of cholesterol gallstones retained in the common bile duct.For long-term treatment of children who have growth failure due to a lack of adequate endogenous growth hormone secretion.

For use in the long-term treatment of children who have growth failure due to a lack of adequate endogenous growth hormone secretion.

For avoidance of the complication of calcium stone formation in patients with uric lithiasis.

Prevention of calcium renal stones in patients with hypocitraturia.

For blockade of the pharmacological effects of exogenously administered opioids as an adjunct to the maintenance of the opioid-free state in detoxified formerly opioid-dependent individuals.

Cromolyn sodium 4% ophthalmic solution

For patients with radiolucent stones in well opacifying gallbladders, in whom elective surgery would be undertaken except for the presence of increased surgical risk due to systemic disease or age.Amelioration of recurrent attacks of acute intermittent porphyria (AIP) temporarily related to the menstrual cycle in susceptible women and similar symptoms which occur in other patients with AIP, porphyria

3/31/2003

2/1/2008

Treatment of pancreatic cancer 1/10/2008

Treatment of cholangiocarcinoma 1/10/2008

Treatment of Gaucher disease 9/17/2008

Treatment of pulmonary tuberculosis (active disease) 1/10/2005

8/10/2004

Treatment of acute lymphoblastic leukemia 8/13/2004

Treatment of T-cell non-Hodgkin's lymphoma 1/29/2004

FK778 1/10/2005

Treatment of tuberculosis. 7/5/2007

8/19/2003

Gimatecan Treatment malignant glioma 11/29/2002

CoFactor 8/13/2004

12/8/2004

(+/-)-7-[3-(4-acetyl-3-methoxy-2-propylphenoxy)propoxy]-3,4-dihydro-8-propyl-2H-1-benzopyran-2-carboxylic acid

Prevention of serious adverse events associated with vascular leak syndrome caused by Interleukin-2 therapy

(+/-)-cis-3-(4-hydroxyphenyl)-4-(4-methoxyphenyl)-3,4-dihydro-2H-cromen-7-ol

Treatment of Stage IIB through Stage IV malignant melanoma

(+/-)-cis-3-(4-hydroxyphenyl)-4-(4-methoxyphenyl)-3,4-dihydro-2H-cromen-7-ol(+/-)-cis-3-(4-hydroxyphenyl)-4-(4-methoxyphenyl)-3,4-dihydro-2H-cromen-7-ol(1R,2R)-Octanoic acid [2-(2',3'-dihydrobenzo[1,4]dioxin-6'-yl)-2-hydroxy-l-pyrrolidin-1-ylmethyl-ethyl]-amide-L-tartaric acid salt(1R,2S) 6-bromo-alpha-[2-(dimethylamino)ethyl]-2-methoxy-alpha-(1-naphthyl)-beta-phenyl-3-quinolineethanol(1S)-1-(9-deazahypoxanthin-9-yl)-1,4-dideoxy-1,4-imino-D-ribitol-hydrochloride

Treatment of chronic lymphocytic leukemia and related leukemias to include prolymphocytic leukemia, adult T-cell leukemia, and hairy cell leukemia

(1S)-1-(9-deazahypoxanthin-9-yl)-1,4-dideoxy-1,4-imino-D-ribitol-hydrochloride(1S)-1-(9-deazahypoxanthin-9-yl)-1,4-dideoxy-1,4-imino-D-ribitol-hydrochloride(2Z)-2-cyano-3-3hydroxy-N-[4-(trifluoromethly)phenyl]-2-hepten-6-ynamide

Prevention of acute rejection following kidney, heart, and liver tranplantation(3S)-3-(4-

trifluoromethoxybenzyloxy)-6-nitro-2H-3,4-dihydroimidazo[2,1-b]oxazine(3S)-3-[(2S)-2-({N-[2-tert-butyl)phenyl]carbamoyl}carbonylamino) propanoylamino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)

Treatment of patients undergoing solid organ transplantation.(4S)-4-ethyl-4-hydroxy-3,14-

dioxo-3,4,12,14-tetrahydro-1-H-pyrano[3?,4?:6,7]-indolizino-[1,2-b]-quinoline-11-carbaldehyde O-

(6R,S)5,10-methylene-tetrahydrofolic acid

For use in combination with 5-fluorouracil for the treatment of patients with pancreatic cancer

(9-[N-(3-morpholinopropyl)-sulfonyl]-5,6-dihydro-5-oxo-11-H-indeno [1,2-c] isoquinoline methanesulfonic acid

Prevention of post-operative complications of aortic anuerysm surgical repair

Treatment of pulmonary tuberculosis. 7/12/2007

Treatment of small cell lung cancer 12/19/2007

Treatment of multiple myeloma 5/5/2008

Treatment of chronic lymphocytic leukemia 12/19/2007

10/3/2001

7/3/2003

(s)-3'-(HO)-DADFT-PE 2/4/2009

Treatment of acute sensorineural hearing loss 3/28/2006

Treatment of postherpetic neuralgia. 2/17/2009

9/17/2008

Treatment of Amyotrophic Lateral Sclerosis 11/4/2003

[Lu-177]-DOTA-Tyr3-Octreotate 1/12/2009

Treatment of erythropoietic porphyrias 7/17/2008

Treatment of Fabry's disease. 5/12/1998

(R)-2-methyl-6-nitro-2-{4-[4-(4-trifluoromethoxyphenoxy)piperidin-1-yl]phenoxymethyl}-2,3-dihydroimidazo[2,1-b]oxazole(R)-4-(3-morpholin-4-yl-1-phenylsulfanylmethyl-propylamino)-N-(4-{4-[2-(4-chlorophenyl)-5,5-(R)-4-(3-morpholin-4-yl-1-phenylsulfanylmethyl-propylamino)-N-(4-{4-[2-(4-chlorophenyl)-5,5-(R)-4-(3-morpholin-4-yl-l-phenylsulfanylmenthyl-propylamino)-N-(4-{4-[2-(4-chlorophenyl)-5,5-

(R)-N-[2-(6-chloro-5-methoxy-1H-indol-3-yl)propyl]acetamide

Treatment of circadian rhythm sleep disorders in blind people with no light perception

(R)-N-[2-(6-Chloro-methoxy-1H-indol-3yl)propyl]acetamide

Treatment of neuroleptic-induced tardive dyskinesia in schizophrenia patients

Treatment of chronic iron overload in patients with transfusion-dependent anemias

(UDU-stereoisomer of c-UJUun UNU-terminal UkUnhibitor)

(Z-8-methyl-N-vanillyl-6-nonnamide) ; Civamide[131I]-N-(2-(diethylamino) ethyl-4-(4 flurobenzamido)-5-(iodo)-2-methoxybenzamide

Treatment of metastatic melanoma, stages IIB, IIC, III and IV[5,10,15,20-tetrakis(1,3-

diethylimidazolium-2-yl)porphyrinato] manganese(III)pentachloride

Treatment of gastro-entero-pancreatic neuroendocrine tumors

[Nle4, D-Phe7]-a-melanocyte stimulating hormone

1,5-(Butylimino)-1,5 dideoxy,D-glucitol

3/13/2008

111Indium pentetreotide SomatoTher 6/10/1999

166Ho-DOTMP Treatment of multiple myeloma. 2/10/1999

Gestiva Prevention of preterm birth in singleton pregnancies 1/25/2007

For the treatment of chronic myelogenous leukemia. 9/3/2004

1-Deoxygalactonojirimycin Treatment of Fabry Disease 2/25/2004

1-dexynojirimycin hydrochloride Treatment of Pompe disease 6/18/2007

2 dimethylbutyrate Treatment of beta thalassemia 6/18/2008

Treatment of multiple myeloma. 12/22/2008

Treatment of ovarian carcinoma 3/18/2009

Treatment of familial amyloid polyneuropathy 5/23/2006

Atiprimod 12/2/2003

Atiprimod Treatment of carcinoid tumors 9/18/2006

2',3',5'-tri-o-acetyluridine Treatment of mitochondrial disease 1/13/2003

11-(2-Pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.12,6.18,12}heptacosa-

For treatment of myeloproliferative disorders (MPD) with the JAK2 V617F mutation.

Treatment of somatostatin receptor positive neuroendocrine tumors.

17 a-Hydroxyprogesterone caproate17-allylamino-17-demethoxygeldanamycin (17-AGG)

2-(2-phenylvinyl)-4-[4-methylpiperazin-l-yl)]-6-(5-methyl-2H-pyrazol-3-yl-amino)-pyrimidine L(+) tartrate salt2-(2-phenylvinyl)-4-[4-methylpiperazin-l-yl)]-6-(5-methyl-2H-pyrazol-3-ylamino)-pyrimidine L(+) tartrate salt 2-(3,5-dichloro-phenyl)-benzoxazole-6-carboxylic acid2-(3-diethylaminopropyl)-8,8-dipropyl-2-azaspiro [4,5] decan dimaleate

Treatment of mulitple myeloma and associated bone resorption

2-(3-Diethylaminopropyl)-8,8-dipropyl-2-azaspiro[4,5] decane dimaleate

Treatment of amyothrophic lateral sclerosis (ALS). 10/11/2007

PreVonco (tm) Treatment of hepatocellular carcinoma. 8/27/2008

12/18/2007

5/9/2008

Treatment of cystic fibrosis 8/15/2003

2-0-desulfated heparin Aeropin Treatment of cystic fibrosis. 9/17/1993

Treatment of stomach cancer 12/10/2004

Treatment of pancreatic cancer 12/8/2004

Treatment of glioblastoma 12/8/2004

Treatment of renal cell carcinoma 12/1/2004

Treatment of ovarian cancer 12/1/2004

2'-3'-dideoxyadenosine Treatment of aquired immunodeficiency syndrome. 7/21/1987

24,25 dihydroxycholecalciferol Treatment of uremic osteodystrophy. 2/27/1987

Treatment for malignant gliomas 8/3/2001

2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N6-propyl-, dihydrochloride, monohydrate, (6R)-; (6R)-4,5,6,7-tetrahydro-N6-2-[(3-methyl-4-(2,2,2-trifluoroethoxy) pyridin-2-yl)methylsulfinyl] -1H-benzoimidazole

2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimadazole-4-carboxamide

Treatment of malignant melanoma stages IIb through IV.

2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimadazole-4-carboxamide

Treatment glioblastoma multiforme when used in combination with DNA-damaging agents

2-0-Butyryl-1-0-octyl-myo-inositol 3,4,5,6-tetrakisphosphate

20-mer complementary to Akt mRNA

20-mer oligonucleotide complementary to Akt mRNA

20-mer oligonucleotide complementary to Akt mRNA20-mer oligonucleotide complementary to Akt mRNA

20-mer oligonucleotide complementary to Akt mRNA

2-chloroethyl-3-sarcosinamide-1-nitrosourea

Sarmustine Treatment for malignant glioma 11/15/2001

2'-deoxycytidine 9/9/1996

2-iminobiotin Treatment of perinatal asphyxia. 2/24/2009

2-methoxyestradiol PulmoLAR Treatment of pulmonary arterial hypertension 4/11/2005

2-methoxyestradiol Panzem NCD Treatment of ovarian cancer 4/4/2005

2-methoxyestradiol Panzem Treatment of multiforme glioblastoma 6/16/2006

2-methoxyestradiol Panzem Treatment of multiple myeloma 7/10/2001

Treatment of Duchenne muscular dystrophy 11/18/2005

Treatment of von Hippel-Lindau disease. 3/23/2000

Treatment of Kaposi's sarcoma. 9/11/1998

3,4-diaminopyridine Treatment of Lambert-Eaton myasthenic syndrome. 12/18/1990

3,5,3'-triiodothyroacetate 9/20/2000

1/10/2005

9/1/2004

Treatment of spinal muscular atrophy. 3/10/2008

2-chloroethyl-3-sarcosinamide-1-nitrosourea

As a host-protective agent in the treatment of acute myelogenous leukemia.

2'-O-methyl-phosphorothiolate oliogribonucleotide3-(3,5-Dimethyl-1H-2ylmethylene)-1,3-dihydro-indol-2-one

3-(3,5-dimethyl-1H-2ylmethylene)-1,3-dihydro-indol-2-one

Treatment of well-differentiated papillary, follicular or combined papillary/follicular carcinomas of the thyroid gland.

3-[5-(2-fluoro-plhenyl)-[1,2,4]oxadiazole-3-yl]benzoic acid

Treatment of Muscular Dystrophy resulting from premature stop mutations in the dystrohin gene3-[5-(2-fluoro-plhenyl)-

[1,2,4]oxadiazole-3-yl]benzoic acid

For use in the treatment of cystic fibrosis resulting fron a nonsense (premature stopcodon) mutation in the cystic bibrosis transmembrane conductance regulatory gene.

3-[5-(2-fluoro-plhenyl)-[1,2,4]oxadiazole-3-yl]benzoic acid

3'-azido-2',3'dideoxyuridine AZDU Treatment of acquired immunodeficiency syndrome. 11/20/1989

7/28/2008

10/11/2006

Treatment of Huntington disease. 12/12/2005

Theralux PhotodynamTreatment of follicular lymphoma 10/30/2008

Theralux PhotodynamiTreatment of diffuse large B-cell lymphoma 10/30/2008

Theralux Photodynami 10/23/2007

4,5-dibromorhodamine 123 Theralux Irradiation D Treatment of chronic myelogenous leukemia 4/10/2003

Treatment of malignanat glioma 4/27/2009

6/18/2008

7/30/2008

40SD02 12/21/1998

Treatment of hepatocellular carcinoma. 8/22/2007

4-Aminopyridine 12/14/2005

4-aminosalicylic acid Paser Granules 4/26/2006

3-fluoro-5-[5-(2-menthyl-thiazol-4-ylethylnyl)-pyridin-2-yl]-benzonitrile dihydrochloride

Treatment of behavioral abnormalities associated with fragile X syndrome.

4-(2-fluorophenyl)-6-methyl-2-(1-piperzinyl)

Treatment of Chronic Functional Vomiting to include functional vomiting and cyclic vomiting syndrome.

4-(3-Methanesulfonyl-phenyl)-1-propylpiperidine HCl4, 5 dibromorhodamine methyl ester

4, 5 dibromorhodamine methyl ester

4,5 dibromorhodamine methyl ester

For immune reconstitution and prevention of graft versus host disease following allogeneic hematopoietic stem cell transplantation.

4,6,8-trihydroxy-10-(3,7,11-trimethyldodeca-2,6,10-trienyl)-5,10-dihydrodibenzo b,e][1,4]diazepin-11-one4-[[[4-(4-Chlorophenoxy)phenyl]sulfonyl]-methyl] tetrahydro-N-hydroxy-2H-pyran-4-carboxamide

Prophylaxis of organ rejection in patients receiving allogeneic liver transplants4-[1]benzofuro[3,2-d]pyrimidin-4-

yl-N-(1,3-benzodioxol-5-ylmethyl)piperazine-1-carbothioamide

Treatment, in combination with radiotherapy and temozolomide chemotherapy, of patients with glioblastoma multiforme.Treatment of chronic iron overload resulting from conventional transfusional treatment of beta-thalassemia major and sickle cell anemia.4-Amino-1-[5-O-[(2R, 4S)-2-oxido-

4-(4-pyridinyl)-1, 3, 2-dioxaphosphorinan-2-yl]-b-D-arabinofuranosyl]-2(1H)-

Treatment chronic functional motor and sensory deficits from Guillain-Barre syndrome

Treatment of acute flares in pediatric patients with ileo-cecal Crohn's disease

4-aminosalicylic acid Pamisyl (P-D), Rezipa 12/13/1989

4-cholest-en-3-one, oxime Treatment of amyotrophic lateral sclerosis 12/1/2005

Treatment of acute myeloid leukemia 7/20/2006

Treatment of smallpox. 12/27/2006

post exposure prophylaxis against smallpox 12/18/2006

Treatment of osteosarcoma (bone cancer) 6/15/2007

Treatment of malignant gliomas 10/11/2006

Treatment of pancreatic cancer 8/20/2003

5,6-dihydro-5-azacytidine Treatment of malignant mesothelioma. 5/11/1992

Prevention of acute radiation syndrome 6/18/2007

Resveratrol Treatment of MELAS syndrome 3/13/2008

506U78 Treatment of chronic lymphocytic leukemia. 9/2/1999

5a8, monoclonal antibody to CD4 12/20/1993

5-aza-2'-deoxycytidine Treatment of acute leukemia. 8/3/1987

Treatment of mild to moderate ulcerative colitis in patients intolerant to sulfasalazine.

4-cyano-N-[2-(1-cyclohexen-1-yl)-4-[1-[dimethylamino)acetyl]-4-piperidinyl]phenyl]-1H-imidazole-2-carboxamide 4-trifluoromethyl-N-(3.3a.4.4a.5,5a,6,6a-octahydro-1,3-dioxo-4,6ethenocycloprop[f]isoindol-4-trifluoromethyl-N-(3.3a.4.4a.5,5a,6,6a-octahydro-1,3-dioxo-4,6ethenocycloprop[f]isoindol-

5(S)-(2'-hydroxy ethoxy)-20(S)-Camptothecin5,12-Naphthacenedione, 10-[[3-amino-2,3,6-trideoxy-4-O-(phenylmethyl)-a-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-5,5',5"-[Phosphinothioylidyne-tris(imino-2,1-ethanediyl)]tris[5-methylchelidoninium]trihydroide hexahydrochloride

5,7-dihydroxy-3-(4-hydroxyphenyl)-chromen-4-one

5-[(E)-2-(4-hydroxyphenyl)-ethenyl] benzene-1,3 diol

For use in post-exposure prophylaxis for occupational exposure to human immunodeficiency virus.

5-Azacitidine Vidaza Treatment of acute myeloid leukemia 6/18/2008

5-hydroxymethyl-2-furfuraldehyde Treatment of sickle cell disease 5/26/2006

Treatment of malginant glioma 5/26/2006

Pirfenidone Treatment of idiopathic pulmonary fibrosis 3/5/2004

Treatment of acute myeloid leukemia. 6/18/2008

Treatment of primary biliary cirrhosis 4/9/2008

Treatment of pancreatic cancer 2/6/2006

Treatment of primary sclerosing cholangitis 4/9/2008

6-hydroxymethylacylfulvene 4/6/1999

8-methoxsalen Uvadex 6/22/1993

8-methoxsalen Uvadex 5/12/1994

90Y-hPAMA4 PAN-Cide Treatment of pancreatic cancer 1/29/2004

9-cis-retinoic acid 1/2/1997

9-nitro-20-(S)-camptothecin Treatment of pancreatic cancer. 9/16/1996

9-nitro-20-(S)-camptothecin Camvirex Treatment of pediatric HIV infection/AIDS 5/15/2001

5-iodo-2-pytimidinone-2'-deoxyribose

5-methyl-1-phenyl-2-(1H)-pyridone(CAS 53179-13-8)

5'-O-(trans-9''-octadecenoyl)-1-B-D-arabinofuranosyl cytosine

6 alpha-ethylchenodeoxycholic acid6,8-bis-benzylsulfanyl-octanoic acid6-alpha-ethylchenodeoxycholic acid

Treatment of histologically confirmed advanced or metastatic pancreatic cancer.

For use in conjunction with the UVAR photopheresis to treat diffuse systemic sclerosis.

For the prevention of acute rejection of cardiac allografts.

Prevention of retinal detachment due to proliferative vitreoretinopathy.

Treatment of pediatric HIV-infection/AIDS patients

Actimid Treatment of multiple myeloma 1/15/2003

A10 & AS2-1 Antineoplaston Treatment for patients with brain stem glioma 9/3/2004

AAV2-hRPE65v2 6/24/2008

Abetimus Treatment of lupus nephritis. 7/28/2000

ACA125 Treatment of epithelial ovarian cancer 11/25/2003

Acetylcysteine Mucomyst/Mucomyst 8/13/1987

Acid sphingomyelinase 8/3/2000

Adalimumab Humira Treatment of pediatric Crohn's disease. 10/19/2006

Treatment of lipoprotein lipase deficiency 5/21/2007

Coagulin-B 6/13/2001

Coagulin-B 6/13/2001

Treatment of Pompe disease 3/20/2007

Treatment of X-linked juvenile retinoschisis (XLRS). 5/21/2007

a-(3-aminophthalimido) glutaramide

Treatment of Leber congenital amaurosis due to RPE65 mutations.

Intravenous treatment of patients presenting with moderate to severe acetaminophen overdose.

Treatment of acid sphingomyelinase deficiency (Niemann-Pick disease).

Adeno-associated vector expressing the human lipoprotein lipase proteinAdeno-associated viral vector containing the gene for human coagulation factor IX

Intramuscular treatment of patients with moderate to severe hemophilia

Adeno-associated viral vector containing the gene for human coagulation factor IX

Intrahepatic treatment of patients with moderate to severe hemophilia

Adeno-associated viral vector expressing human acid alpha glucosidase gene

adeno-associated viral vector expressing human retinoschisin-1 gene

Treatment of Stargardt's disease. 9/30/2008

Treatment of cystic fibrosis. 2/15/1995

Adenosine 8/1/1989

Treatment of malignant brain tumors 6/17/2005

MiniAdFVIII Treatment of hemophilia A. 12/15/1999

7/31/2001

1/3/1989

a-Galactosidase A Plant-Produced HumaTreatment of Fabry's disease 1/21/2003

Treatment of new-onset type I diabetes mellitus 2/6/2006

AI-RSA Treatment of autoimmune uveitis. 10/8/1992

Albuterol Prevention of paralysis due to spinal cord injury 3/12/2002

ALD-101 10/23/2008

Aldesleukin Proleukin 3/22/1989

Aldesleukin Proleukin Treatment of acute myelogenous leukemia. 7/31/1998

Adeno-associated viral vector serotype 5 containing human ABCA4 gene

Adeno-associated viral-based vector cystic fibrosis gene therapy

For use in conjunction with BCNU in the treatment of brain tumors.

Adenoviral vector expressing Herpes simplex virus thymidine kinase geneAdenovirus-based vector Factor VIII complementary DNA to somatic cellsadenovirus-mediated herpes simplex virus-thymidine kinase gene

Use with gancyclovir in the treatment of malignant glioma

Aerosolized pooled immune globulin

Treatment of respiratory syncytial virus lower respiratory tract disease.

Aglycosyl anti-CD3 monoclonal antibody

To improve patient outcomes by decreasing time to platlet and neutrophil engraftment in patients with inherited metabolic diseases (IMD) undergoing umbilical cord blood transplantation.

Treatment of primary immunodeficiency disease associated with T-cell defects.

Aldesleukin Proleukin For the treatment non-Hodgkin's lymphoma. 11/24/1998

Alefacept Amevive 12/19/2007

alendronate Fosamax 3/31/2003

Alendronate disodium Fosamax 2/13/2001

Alfentanil Management of postherpetic neuralgia 7/8/2005

Alfentanil Treatment of painful HIV-associated neuropathy 8/9/2005

Alglucerase injection Ceredase 7/21/1995

alicaforsen Treatment of pouchitis. 6/24/2008

Alitretinoin Panretin Treatment of acute promyelocytic leukemia 4/10/1992

allantoin Alwextin 11/21/2002

Vascugel (r) 4/3/2009

Spheramine 7/18/1997

9/12/2008

CYTOIMPLANT Treatment of pancreatic cancer 6/13/1997

Treatment of retinitis pigmentosa 9/1/2004

For use as prophylaxis of rejection in patients receiving allogenic solid organ transplants.

Treatment of osteogenesis imperfecta in pediatric patients 4 years of age and older

Treatment of the bone manifestations of Gaucher disease

Replacement therapy in patients with Type II and III Gaucher's disease.

Treatment of skin blistering and erosions associated with inherited epidermolysis bullosa

Allogeneic human aortic endothelial cells cultured in a porcine gelatin matrix

Prevention of arteriovenous fistula or arteriovenous graft failure in patients with end satge renal disease receiving hemodialysis or preparing for hemodialysis

Allogeneic human retinal pigment epithelial cells on gelatin microcarriers

Treatment of Hoehn and Yahr stage 3 and 4 Parkinson's disease.allogeneic mesenchymal

precursor cells derived from ex vivo healthy donors harvested from iliac crest.

Treatment of insufficient hematopoietic stem cell production in patients with hematologic malignancies who have failed treatment with conventional chemotherapy.Allogeneic peripheral blood

mononuclear cells sensitized against patient alloantigens by mixed lymphocyte cultureAllogeneic retinal epithelial cells transfected with plasmid vector expressing ciliary neurotrophic growth factor

1/28/2005

Allopurinol riboside Treatment of cutaneous and visceral leishmaniasis. 12/4/1985

Allopurinol riboside Treatment of Chagas' disease. 12/4/1985

Allopurinol sodium 11/9/1987

Alpha-1-acid glycoprotein Treatment of cocaine overdose 3/5/2004

Alpha-1-acid glycoprotein Treatment of tricyclic antidepressant poisoning 3/17/2004

1/1/1984

Alpha1-antitrypsin(human) Treatment of bronchiectasis 4/3/2008

12/22/2004

ARC-API Treatment of cystic fibrosis 9/1/2004

Treatment of cystic fibrosis 2/20/2009

11/24/1999

Alpha-galactosidase A Fabrase Treatment of Fabry's disease. 7/20/1990

Alpha-galactosidase A CC-galactosidase 6/17/1991

Allogeneic T-cells cultured with anti-CD3 and IL-2; transduced with retroviral vector (SFCMM-3), expressing herpes simplex 1

Immunotherapy for acceleration of T-cell reconstitution in patients undergoing allogeneic hematopoietic stem cell transplantation

Ex-vivo preservation of cadaveric kidneys for transplantation

Alpha-1-antitrypsin (recombinant DNA Origin)

As supplementation therapy for alpha-1-antitrypsin deficiency in the ZZ phenotype population.

Alpha1-Proteinase Inhibitor (Human)

Inhalation therapy for the the treatment of congential deficiency of alpha1-proteinase inhibitor.

Alpha1-Proteinase Inhibitor (Human)

alpha1-proteinase inhibitor (human)

Alpha1-proteinase inhibitor (human)

For slowing the progression of emphysema in alpha1-antitrypsin deficient patients.

Treatment of alpha-galactosidase A deficiency (Fabry's disease).

Alpha-galactosidase A Replagal 6/22/1998

8/19/1997

Alpha-tocopherol quinone 3/28/2006

Alprostadil 10/20/1993

alteplase Activase 1/27/2003

Alvocidib 4/13/2007

Treatment of thrombotic thrombocytopenic purpura 4/14/2009

AMG 531 10/31/2007

Amifostine Ethyol Treatment of myelodysplastic syndromes. 10/4/1999

Amifostine Ethyol 5/30/1990

Amifostine Ethyol 5/30/1990

Amifostine Ethyol 11/24/1998

Amikacin SLIT Amikacin 3/9/2006

Treatment of cystic fibrosis. 7/18/1990

Aminocaproic acid Caprogel 1/6/1995

Aminolevulinic acid hydrochloride Levulan Treatment of esophageal dysplasia 3/20/2007

Long-term enzyme replacement therapy for the treatment of Fabry disease.

Alpha-melanocyte stimulating hormone

Prevention and treatment of intrinsic acute renal failure due to ischemia.

Treatment of inherited mitochondrial respiratory chain diseases

Treatment of severe peripheral arterial occlusive disease (critical limb ischemia) in patients where other procedures, grafts or angioplasty, are not indicated.

Treatment of intraventricular hemmorage associated with intracerebral hemmorrhage

Teatment of B-cell chronic lymphocytic leukemia (B-CLL) or prolymphocytic leukemia arising from CLL.

ALX-0081 nanobody, directed towards the human A1 domain of von Willebrand factor

Treatment of thrombocytopenia associated with myelodysplasia syndrome

For use as a chemoprotective agent for cisplatin in the treatment of metastatic melanoma.For use as a chemoprotective agent for cyclophosphamide in the treatment of advanced ovarian carcinoma.

For the reduction of the incidence and severity of toxicities associated with cisplatin administration.

Treatment of bronchopulmonary Pseudomonas aeruginosa infections in cystic fibrosis patients

Amiloride HCl solution for inhalation

For the topical treatment of traumatic hyphema of the eye.

Aminosalicylate sodium Treatment of Crohn's disease. 4/6/1993

Aminosidine Paromomycin Treatment of visceral leishmaniasis 3/29/2005

Aminosidine Paromomycin Treatment of visceral leishmaniasis (kala-azar). 9/9/1994

Aminosidine Gabbromicina Treatment of tuberculosis. 5/14/1993

Aminosidine Gabbromicina Treatment of Mycobacterium avium complex. 11/15/1993

Amiodarone Amio-Aqueous Treatment of incessant ventricular tachycardia. 8/17/1993

ammonium tetrathiomolybdate Treatment of idiopathic pulmonary fibrosis 5/5/2008

Ammonium tetrathiomolybdate Coprexa Treatment of Wilson's disease. 1/31/1994

Amonafide L-malate Xanafide Treatment of acute myeloid leukemia 12/20/2006

Amphotericin B inhalation powder 12/15/2005

Amphotericin B lipid complex Abelcet Treatment of invasive protothecosis. 8/21/1996

Amphotericin B lipid complex Abelcet Treatment of invasive sporotrichosis. 9/23/1996

Amphotericin B lipid complex Abelcet Treatment of invasive coccidioidomycosis. 5/6/1996

Amphotericin B lipid complex Abelcet Treatment of invasive zygomycosis. 5/6/1996

Amphotericin B lipid complex Abelcet Treatment of invasive candidiasis. 6/27/1996

Prevention of pulmonary fungal infections in patients at risk for aspergillosis due to immunosuppressive therapy including those receiving organ or stem cell transplants, or teated with chemotherapy or radiation for

amrubicin Treatment of small cell lung cancer 3/10/2008

Amsacrine Amsidyl Treatment of acute adult leukemia. 12/7/1984

Cyanide Antidote Kit Treatment of cyanide poisoning 12/18/2006

Anagrelide Agrylin 7/14/1986

Anagrelide Agrylin Treatment of polycythemia vera. 6/11/1985

Ananain, comosain Vianain For the enzymatic debridement of severe burns. 1/21/1992

Anaritide acetate Auriculin Treatment of patients with acute renal failure. 8/27/1992

Anaritide acetate Auriculin 4/10/1992

Anatibant 4/15/2005

Ancrod Viprinex 10/20/1989

Angiotensin 1-7 MARstem Treatment of myelodysplastic syndrome 8/3/2001

Angiotensin 1-7 2/16/2000

anthrax immune globulin (human) 7/29/2008

Treatment of acute spinal cord injury 10/20/2008

Anti-t Lymphocyte Im 1/29/1986

Amyl nitrite, sodium nitrite, sodium thiosulfate

Treatment of thrombocytosis in chronic myelogenous leukemia.

Improvement of early renal allograft function following renal transplantation.Treatment of patients having experienced a severe traumatic brain injury (Glasgow Coma Scale 3 to 8) in order to decrease early mortality and improve long-term functional and neurological outcome

To establish and maintain anticoagulation in heparin-intolerant patients undergoing cardiopulmonary bypass.

Treatment of neutropenia associated with autologous bone marrow transplantation.

Treatment of toxemia associated with inhalational anthrax.

anti human Nogo-A human monoclonal antibodyAnti pan T lymphocyte monoclonal antibody

For ex-vivo treatment to eliminate mature T cells from potential bone marrow grafts.

Anti-t Lymphocyte Im 1/29/1986

Neovastat (AE-941) Treatment of renal cell carcinoma 10/16/2002

Treatment of chronic lymphocytic leukemia 2/12/2003

Treatment of Hodgkin lymphoma 12/2/2008

Anti-CD40 mAb Treatment of chronic lymphocytic leukemia 10/6/2005

Anti-CD45 monoclonal antibodies 9/10/1990

Treatment of pancreatic cancer 5/21/2003

5/2/1990

5/2/1990

5/3/1990

5/3/1990

Treatment of stage IIb to stage IV metastatic melanoma 9/18/2006

Antiepilepsirine 3/23/1989

Kogenate(r) FS Treatment of hemophilia A 4/29/2009

11/18/2003

Anti pan T lymphocyte monoclonal antibody

For in-vivo treatment of bone marrow recipients to prevent graft rejection and graft versus host disease.

antiangiogenic components extracted from marine cartilageanti-CD23 IgG1, kappa monoclonal antibody

anti-CD30 Fc engineered humanized monoclonal antibody

Prevention of acute graft rejection of human organ transplants.

Anti-CEA Sheep-human chimeric monoclonal antibody labeled w/iodine-131 (KAb201)

Anti-cytomegalovirus monoclonal antibodies

Prevention of human cytomegalovirus infection in bone marrow and organ transplant patients.

Anti-cytomegalovirus monoclonal antibodies

Treatment of human cytomegalovirus infection in bone marrow and organ transplant patients.

Anti-cytomegalovirus monoclonal antibodies

Prevention of human cytomegalovirus infection in patients diagnosed with AIDS.

Anti-cytomegalovirus monoclonal antibodies

Treatment of human cytomegalovirus infection in patients diagnosed with AIDS.

Anti-cytotoxic T lymphocyte antigen 4 monoclonal antibody

Treatment of drug resistant generalized tonic-clonic epilepsy in children and adults.Antihemophilic factor

(recombinant) formulated with sucrose reconstituted with liposome diluent

anti-interferon-gamma Fab from goats

For the treatment of immunologic corneal allograft rejection

Antimelanoma Antib 11/14/1984

Antimelanoma Antib 11/14/1984

Treatment of gliomas 10/30/2008

Antipyrine Test 2/21/1985

Treatment of acute myeloid leukemia 4/15/2005

GTI-2040 Treatment for renal cell carcinoma 3/12/2003

Antisense inhibitor of apoB-100 5/23/2006

Nexagon Treatment of persistent corneal epithelial defects 4/27/2009

4/3/2009

Anti-tap-72 immunotoxin Xomazyme-791 Treatment of metastatic colorectal adenocarcinoma. 3/6/1987

Neuradiab Treatment of primary malignant brain tumors 10/4/2005

Kybernin P 7/2/1985

Antithrombin III human Antithrombin III huma 1/2/1986

Anti-thymocyte Globulin (Rabbitt) Thymoglobulin Treatment of myelodysplastic syndrome (MDS) 9/6/2000

Antimelanoma Antibody XMMME-001-DTPA 111 Indium

Diagnostic use in imaging systemic and nodal melanoma metastasis.

Antimelanoma Antibody XMMME-001-RTA

Treatment of stage III melanoma not amenable to surgical resection.

antineoplaston A10, antineoplaston AS2-1

For use as an index of hepatic drug-metabolizing capacity.Antisense 20-mer oligonucleotide

complementary to R2 component of ribonucleotide reductase mRNAantisense 20-mer phosphorothioate oligonucleotide [complementary to the coding region of R2 component of the

Treatment of homozygous familial hypercholesterolemia

Antisense oligonucleotide directed against connexin43

Anti-T cell receptor murine monoclonal antibody

Prophylaxis of acute rejection of solid organ transplantation

Anti-tenascin 81C6 monoclonal antibody labeled w/ I 131

Antithrombin III (human) concentrate IV

For prophylaxis and treatment of thromboembolic episodes in patients with genetic AT-III deficiency.Preventing or arresting episodes of thrombosis in patients with congenital AT-III deficiency and/or to prevent the occurrence of thrombosis in patients with AT-III deficiency who have undergone trauma or who

Anti-thymocyte serum Nashville Rabbit Ant 6/2/1993

9/12/2008

Antivipmyn Treatment of envenomation by Crotaline snakes 1/29/2004

2/12/1991

Anti-von Willebrand Aptamer Treatment of thrombotic thrombocytopenic purpura 4/9/2008

AP1903 11/24/1999

APL 400-020 V-Beta DNA vaccine Treatment of cutaneous T cell lymphoma. 3/8/1995

Apomorphine 10/20/1997

Apomorphine 7/17/1995

Apomorphine hydrochloride 5/23/2006

AQ-13 (4-aminoquinoline analog) Treatment of malaria 9/12/2008

Arcitumomab 99m Tc-labeled CEA- 5/10/1996

Arenegyr Treatment of malignant plueral mesothelioma 8/22/2008

Arginine butyrate Treatment of sickle cell disease and beta thalassemia. 5/25/1994

Treatment of allograft rejection, including solid organ (kidney, liver, heart, lung, and pancreas) and bone marrow transplantation.

anti-T-lymphocyte immune globulin, rabbit

Prophylaxis of acute allograft rejection in adult recipients in solid organ transplantation.

Antivenin crotaline (pit-viper) equine immune F(ab)2)

Antivenom (crotalidae) purified (avian)

Treatment of envenomation by poisonous snakes belonging to the Crotalidae family.

Treatment of acute graft-versus-host disease in patients undergoing bone marrow transplantation.

For use as rescue treatment for early morning motor dysfunction in late-stage Parkinson's disease.

Treatment of the on-off fluctuations associated with late-stage Parkinson's disease.For the treatment of patients in a vegetative state or minimally conscious state for up to 12 months following a severe traumatic brain injury (traumatic or spontaneous)

Diagnosis and localization of primary, residual, recurrent and metastatic medullary thyroid carcinoma.

Arginine butyrate 4/7/1992

arimoclomol Treatment of amyotrophic lateral sclerosis 3/29/2005

Aripiprazole Abilify Treatment of Tourette's syndrome 1/25/2006

arsenic Trisenox 11/2/2001

Arsenic trioxide Trisenox Treatment of malignant glioma 3/4/2005

arsenic trioxide Trisenox Treatment of chronic myeloid leukemia 10/18/2001

Arsenic trioxide Trisenox Treatment of multiple myeloma. 4/28/2000

arsenic trioxide Trisenox Treatment of liver cancer 6/13/2003

Arsenic trioxide Trisenox Treatment of chronic lymphocytic leukemia 5/13/2003

arsenic trioxide Trisenox Treatment of myelodysplastic syndrome. 7/17/2000

artemether/lumefantrine Coartem 8/31/2007

Artesunate Treatment of malaria. 7/19/1999

Artesunate Immediate treatment of malaria 3/28/2006

Treatment of beta-hemoglobinopathies and beta-thalassemia.

Treatment of acute myelocytic leukemia subtypes M0, M1, M2, M4, M5, M6 and M7

For the treatment of infections due to Plasmodium falciparum or mixed infections including P. falciparum.

arylsulfatase A (rhARSA) Treatment of metachromatic leukodystrophy. 2/27/2008

As-101 Treatment of acquired immunodeficiency syndrome. 11/9/1987

Ascorbic acid Ascor L 500 Treatment of scurvy 8/31/2007

Atomoxetine hydrochloride STRATTERA Treatment of Tourette's Syndrome 8/26/2003

Atovaquone Mepron 3/16/1993

Atovaquone Mepron 3/16/1993

4/27/2007

Mylovenge Treatment of multiple myeloma 4/18/2002

6/1/2007

DCVax-Brain Treatment of primary brain malignant cancer 11/29/2002

M-Vax 2/23/1999

9/3/2004

Theralux photodynamiTreatment of chronic graft versus host disease 4/3/2008

RhinoCytes Treatment of amyotrophic lateral sclerosis 12/31/2008

RhinoCytes 2/1/2008

Primary prophylaxis of HIV-infected persons at high risk for developing Toxoplasma gondii encephalitis.

Treatment and suppression of Toxoplasma gondii encephalitis.Attenuated autologous cancer

cells and granulocyte macrophage colony stimulating factor in combination with activated

Treatment of primary central nervous system malignanciesautologous antigen presenting

cells pulsed with autologous tumor Ig idiotypeAutologous cultured endothelial cells on a donor human corneal disk

Treatment of Fuch's dystrophy, pseudophakic bullous keratopathy, and bullous keratopathy

Autologous dendritic cells pulsed with autologous antigens from primay malignant brain tumor cellsAutologous DNP-conjugated tumor vaccine

For adjuvant therapy in melanoma patients with surgically resectable lymph node metastasis (Stage III and limited Stage IV disease).

Autologous incubated macrophage

Therapy to improve the motor and sensory neurological outcome in acute cases of spinal cord injuryautologous lymphocytes depleted

ex vivo of immunoreactive T cells using 4,5

autologous olfactory neural progenitors

Autologous olfactory neural progenitors

Treatment of spinal cord injury patients with ASIA Impairment grades A, B, or C

7/14/2005

Oncophage Treatment of renal cell carcinoma 5/10/2002

Oncophage Treatment of metastatic melanoma 7/11/2002

Autolymphocyte therapy Treatment of renal cell carcinoma. 7/12/1994

aviptadil Treatment of pulmonary arterial hypertension 2/22/2005

axitinib Treatment of pancreatic cancer 5/31/2007

Azathioprine Imuran 9/14/1999

aztreonam 3/12/2002

Bacillus Calmette-Guerin vaccine Treatment of stage IIb through IV metastatic melanoma 8/9/2006

Bacitracin Altracin 3/13/1984

Baclofen 12/16/1991

Baclofen Lioresal Intrathecal Treatment of spasticity associated with cerebral palsy. 9/26/1994

baclofen Treatment of dystonia 12/2/2003

Bardoxolone Treatment of pancreatic cancer 8/6/2008

Autologous or allogeneic limbal epithelial stem cells expanded ex vivo on human amniotic membrane

Treatment of ocular surface diseases that are characterized by total limbal stem cell deficiency

autologous tumor-derived gp96 heat shock protein-peptide complexautologous tumor-derived gp96 heat shock protein-peptide complex

Treatment of oral manifestations of graft-versus-host disease.

Inhalation therapy for control of gram-negative bacteria in the respiratory tract of patients with cystic fibrosis

Treatment of antibiotic-associated pseudomembranous enterocolitis caused by toxins A and B elaborated by Clostridium difficile.

Treatment of intractable spasticity due to multiple sclerosis or spinal cord injury.

beclomethasone Treatment of pediatriac patients with ulcerative colitis 3/4/2009

Bec Prevention of gastrointestinal graft-versus-host disease 8/28/2001

Treatment of pediatric patients with Crohn disease. 12/18/2007

Beclomethasone dipropionate 3/27/1998

belatacept 2/20/2008

Total Block VL SPF 7 8/13/2001

Benzydamine hydrochloride Tantum 5/18/1998

Pre-Pen/MDM 9/29/1987

Beractant Survanta Intratrachea 12/20/1993

Beraprost 4/29/1999

Beta alethine Betathine Treatment of metastatic melanoma. 3/24/1997

Beta alethine Betathine Treatment of multiple myeloma. 3/24/1997

Betahistine dihydrochloride 11/8/2007

Bethanidine sulfate 11/24/1989

Bethanidine sulfate Treatment of primary ventricular fibrillation. 9/20/1988

beclomethasone 17,21-dipropionate

beclomethasone 17,21-diproprionate

For oral administration in the treatment of intestinal graft-versus-host disease.

Prophylaxis of organ rejection in renal allograft recipientsBenzophenone-3,

octylmethoxycinnamate, avobenzone, titanium dioxide, zinc oxide

For the prevention of visible light induced skin photosensitivity as a result of porfimer sodium photodynamic therapy

Prophylactic treatment of oral mucositis resulting from radiation therapy for head and neck cancer.

Benzylpenicillin, benzylpenicilloic, benzylpenilloic acid

Assessing the risk of administrating penicillin when it is the preferred drug of choice in adult patients who have previously received penicillin and have a history of clinical sensitivity.Treatment of full-term newborn infants with respiratory failure caused by meconium aspiration syndrome, persistent pulmonary hypertension of the newborn, or pneumonia and sepsis.Treatment of pulmonary arterial hypertension associated with any New York Heart Association classification (Class I, II, III, or IV).

Treatment of obesity associated with Prader Willi syndrome

Prevention of recurrence of primary ventricular fibrillation.

Betulinic acid Topical treatment of metastatic melanoma 8/9/2007

Bevacizamub Avastin Treatment of malignant glioma 5/26/2006

Bevacizumab Avastin Therapeutic treatment of patients with ovarian cancer 2/9/2006

Bevacizumab Avastin Treatment of pancreatic cancer 10/20/2004

Bevacizumab Avastin Treatment of renal cell carcinoma 11/6/2003

bifidobacterium infantis 35624 Treatment of pediatric ulcerative colitis 3/24/2008

Treatment of pediatric Crohn's disease 1/16/2003

Bindarit Treatment of lupus nephritis. 2/3/1998

2/11/2002

4/27/2006

Treatment of sickle cell disease. 3/2/2000

Treatment of prolymphocytic leukemia 5/16/2008

Treatment for hairy cell leukemia. 5/16/2008

Treatment of chronic lymphocytic leukemia 5/16/2008

Treatment of acute lymphocytic leukemia 5/16/2008

bifidobacterium longum infantis 35624

Bioartificial liver system utilizing xenogenic hepatocytes in a hollow fiber bioreactor cartridge (BAL)

Treatment of patients with acute liver failure presenting with encephalopathy deteriorating beyond Parson's grade 2

Bio-engineered oral mucosal tissue

For use as a graft for restoring a cornea-like epithelial phenotype to substitute for the normal corneal epithelium that is lost in patients due to total limbal stem cell deficiency

Bis(4-fluorophenyl)phenylacetamideBispecific molecule with two linked murine single-chain Fv regions against CD3 & CD19Bispecific molecule with two linked murine single-chain Fv regions against CD3 & CD19Bispecific molecule with two linked murine single-chain Fv regions against CD3 & CD19Bispecific molecule with two linked murine single-chain Fv regions against CD3 & CD19

2/6/2006

bivalirudin Angiomax 11/2/2005

Bleomycin Blenoxane Treatment of pancreatic cancer. 2/9/1999

BMY-45622 Treatment of ovarian cancer. 10/15/1990

bosentan Tracleer Treatment of idiopathic pulmonary fibrosis 9/30/2008

bosutinib Treatment of chronic myelogenous leukemia.

Botulinum toxin type A Dysport 10/20/1999

Botulinum toxin type A Dysport Treatment of spasmodic torticollis (cervical dystonia). 8/12/1998

Botulinum toxin type A Dysport Treatment of essential blepharospasm. 3/23/1989

Botulinum toxin type A Botox 12/6/1991

Botulinum toxin type A 9/15/1992

Botulinum toxin type F Treatment of spasmodic torticollis (cervical dystonia). 10/24/1991

Botulinum toxin type F Treatment of essential blepharospasm. 12/5/1991

Bovine colostrum Treatment of AIDS-related diarrhea. 11/19/1990

Bispecific molecule with two linked murine single-chain Fv regions directed against CD3 & CD19

Treatment of indolent B-cell lymphoma, excluding CLL and NHL with CNS involvement

For use as an anticoagulant in patients with or at risk of heparin-induced thrombocytopenia/heparin-induced thrombocytopenia thrombosis syndrome

Treatment of dynamic muscle contractures in pediatric cerebral palsy patients.

Treatment of dynamic muscle contracture in pediatric cerebral palsy patients.

Treatment of synkinetic closure of the eyelid associated with VII cranial nerve aberrant regeneration.

Sporidin-G 3/1/1994

Bovine whey protein concentrate Immuno-C 9/30/1993

Branched chain amino acids Treatment of amyotrophic lateral sclerosis. 12/23/1988

Brimonidine Alphagan Treatment of anterior ischemic optic neuropathy. 2/7/2000

Brivaracetam Treatment of symtomatic myoclonus 10/5/2005

Brivudin Adjunct treatment of pancreatic cancer 11/15/2007

Bromhexine Bisolvon 5/15/1989

Broxuridine Broxine/Neomark 9/18/1995

bryostatin-1 12/3/2001

Buffered Ursodeoxycholic Acid Ursocarb Treatment of pruritus in patients with Alagille Syndrome 9/3/2004

bupivacaine Transdur 6/18/2008

Busulfan Spartaject 4/21/1994

Busulfan Spartajet-Busulfan Intrathecal therapy for neoplastic meningitis 3/5/2001

busulfan Partaject 11/25/2002

Busulfan Spartaject Treatment of primary brain malignancies. 7/7/1997

Bovine immunoglobulin concentrate, Cryptosporidium parvum

Treatment and symptomatic relief of Cryptosporidium parvum infection of the gastrointestinal tract in immunocompromised patients.Treatment of cryptosporidiosis caused by the presence of Cryptosporidium parvum in the gastrointestinal tract of patients who are immunodeficient/immunocompromised or

Treatment of mild to moderate keratoconjunctivitis sicca in patients with Sjogren's syndrome.

Radiation sensitizer in the treatment of primary brain tumors.

For use in combination with paclitaxel in the treatment of esophageal cancer

Relief of persistent pain asociated with postherpetic neuralgia

For use as preparative therapy for malignancies treated with bone marrow transplantation.

Preparative therapy for pediatric patients undergoing bone marrow transplantation

Buthionine sulfoxamine 10/5/2005

Buthionine sulfoxamine 10/5/2005

Butyrylcholinesterase Treatment of post-surgical apnea. 9/30/1992

Butyrylcholinesterase 3/25/1992

BW 12C Treatment of sickle cell disease. 10/23/1987

C1 esterase inhibitor (human) 8/21/1996

Berinert P 10/16/1992

C1-inhibitor C1-inhibitor (human) 8/30/1990

C1-inhibitor C1-inhibitor (human) Treatment of acute attacks of angioedema. 8/30/1990

cAC10-vcMMAE (4) Treatment of Hodgkin's lymphoma. 1/30/2007

Calcitonin salmon nasal spray Miacalcin Nasal Spra 10/29/1990

Calcium acetate 6/27/1989

Calcium carbonate R & D calcium carbon 6/6/1990

Calcium gluconate Calgonate 11/20/1997

For use in children as a modulator of chemotherapy for the treatment of pediatric patients with neuroblastoma

Use as a modulator of chemotherapy for the treatment of pediatric patients with primary malignant brain tumors

For the reduction and clearance of toxic blood levels of cocaine encountered during a drug overdose.

Treatment and prevention of angioedema caused by C1-esterase inhibitor deficiency.

C1-esterase-inhibitor, human, pasteurized

Prevention and/or treatment of acute attacks of hereditary angioedema.

Prevention of acute attacks of angioedema, including short-term prophylaxis for patients requiring dental or other surgical procedures.

Treatment of symptomatic Paget's disease (osteitis deformans).

Treatment of hyperphosphatemia in end stage renal disease.

Treatment of hyperphosphatemia in patients with end stage renal disease.

For use as a wash for hydrofluoric acid spills on human skin.

Calcium gluconate gel H-F Gel 5/21/1991

Calcium gluconate gel 2.5% 9/10/1990

Calfactant Infasurf Acute respiratory distress syndrome (ARDS) 9/5/2000

canakinumab Treatment of systemic onset juvenile idiopathic arthritis 9/30/2008

Capsaicin Treatment of postherpetic neuralgia. 8/3/2005

Capsaicin 9/29/2006

capsaicin Treatment of erythromelalgia 10/23/2002

Capsaicin Treatment of painful HIV-associated neuropathy 5/2/2003

Carbamylglutamic acid Treatment of N-acetylglutamate synthetase deficiency. 1/20/1998

carbon monoxide Covox 6/24/2008

Carbovir 12/13/1989

cardiotrophin-1 6/24/2008

carfilzomib Treatment of multiple myeloma 1/18/2008

Carmustine Treatment of intracranial malignancies. 7/3/2000

Cascara sagrada fluid extract 3/21/1989

For use in the emergency topical treatment of hydrogen fluoride (hydrofluoric acid) burns.

Emergency topical treatment of hydrogen fluoride (hydrofluoric acid) burns.

Treatment of intermetatarsal neuroma (Morton's Neuroma) that does not respond to conservative treatment and requires either neurectomy or neurolysis

For use in the reduction of the incidence and severity of delayed graft function in patients undergoing solid organ transplanation.

Treatment of persons with AIDS and in patients with symptomatic HIV infection and a CD4 count less than 200/mm3.

To protect the liver from ischemia-reperfusion injury inherent to the procedure of transplantation.

Treatment of oral drug overdosage to speed lower bowel evacuation.

Catumaxomab Removab Treatment of ovarian cancer 6/9/2006

Soluble T4 Treatment of acquired immunodeficiency syndrome. 11/21/1989

CD5-T lymphocyte immunotoxin Xomazyme-H65 8/27/1987

CDP571 Treatment of Crohn's disease. 12/11/1997

CDX-110 11/19/2007

Ceftriaxone sodium Rocephin Treatment of amyotrophic lateral sclerosis 3/28/2006

7/10/2002

cenersen Aezea Treatment of stage IIB through IV melanoma 6/18/2008

cenersen Treatment of acute myeloid leukemia 5/8/2006

cenersen Aezea Treatment of chronic lymphocytic leukemia 2/27/2008

Centruroides immune F(ab)2 Alacramyn 6/12/2000

cethromycin 2/28/2007

Cetiedil citrate injection Treatment of sickle cell disease crisis. 12/22/1988

cetuximab Erbitux Treatment of pancreatic cancer 6/15/2007

Chenodeoxycholic acid Chenofalk Treatment of cerebrotendinous xanthomatosis 1/29/2004

chenodeoxycholic acid Treatment of cerebrotendinous xanthomatosis 2/12/2007

CD4 human truncated 369 AA polypeptide

Treatment of graft versus host disease and/or rejection in patients who have received bone marrow transplants.

Treatment of EGFRvIII-expressing glioblastoma multiforme

Cells produced using the AastromReplicelle System and SC-I Therapy Kit

For use in patients receiving high dose chemotherapy who are unable to generate an acceptable dose of peripheral blood stem cells and who have a sufficient bone marrow aspirate without morphological evidence

Treatment of scorpion envenomations requiring medical attention.

Prophylactic treatment of patients exposed to inhalation anthrax.

Treatment of renal cell carcinoma. 7/24/2000

Treatment of multiple myeloma 10/11/2005

Treatment of Castleman's disease 5/26/2006

Chimeric monoclonal antibodies 10/4/2005

Treatment of pancreatic cancer 10/31/2006

Treatment of multiple sclerosis. 6/5/1991

Treatment of acute myeloid leukemia 4/3/2009

8/3/2000

Peridex 8/18/1986

chlorotoxin Treatment of stage IIb, IIc, III & IV melanoma 12/2/2008

Chlorotoxin Treatment of malignant glioma 12/18/2007

cholest-4-en-3-one, oxime Treatment of spinal muscular atrophy. 2/17/2009

Falkochol 7/18/2003

Choline chloride IntraChol 7/20/2006

Choline chloride Intrachol 2/10/1994

Chimeric (human-murine) G250 IgG monoclonal antibody

chimeric (murine-human) IgG1 mAb against IL-6Chimeric (murine-human) IgG1k monoclonal antibody against interleukin-6

For treatment of shiga-toxin producing bacterial infection.

Chimeric monoclonal antibody to mesothelin

Chimeric M-T412 (human-murine) IgG monoclonal anti-CD4chimeric murine/human IgG1 monoclonal antibody to human interleukin-3 receptor alpha chain

Chimeric, humanized monoclonal antibody to staphylococcus

Prophylaxis of Staphylococcus epidermidis sepsis in low birth weight (1500 grams or less) infants.

Chlorhexidine gluconate mouthrinse

For use in the amelioration of oral mucositis associated with cytoreductive therapy used in conditioning patients for bone marrow transplantation therapy.

cholic acid (3 alpha, 7 alpha, 12 alpha trihydroxy 5-beta cholanolic acid)

Treatment of inborn errors of cholesterol and bile acid synthesis and metabolism

Prevention and/or treatment of choline deficiency in patients on long-term parenteral nutrition

Treatment of choline deficiency, specifically the choline deficiency, hepatic steatosis, and cholestasis, associated with long-term parenteral nutrition.

12/1/1997

Chondroitinase Treatment of patients undergoing vitrectomy. 2/9/1995

cicletanine hydrochloride Treatment for pulmonary arterial hypertension. 6/24/2008

cilengitide Treatment of malignant glioma 5/27/2005

Ciliary neurotrophic factor Treatment of amyotrophic lateral sclerosis. 1/30/1992

5/8/1992

Treatment of spinal muscular atrophies. 4/2/1992

Cisplatin in liposomal formulation SLIT Cisplatin for inhaTreatment of osteogenic sarcoma metastatic to the lung 3/20/2007

Cisplatin/epinephrine IntraDose Treatment of metastatic malignant melanoma. 9/7/2000

Cisplatin/epinephrine IntraDose 4/3/2000

Civamide Zucapsaicin 12/9/2002

Cladribine Leustatin Treatment of acute myeloid leukemia. 7/20/1990

Cladribine Leustatin Injection Treatment of chronic lymphocytic leukemia. 12/31/1990

Cladribine Mylinax 4/19/1994

Cladribine Leustatin Injection Treatment of non-Hodgkin's lymphoma. 4/19/1993

Chondrocyte-alginate gel suspension

For use in correcting vesicoureteral reflux in the pediatric population.

Ciliary neurotrophic factor, recombinant human

Treatment of motor neuron disease (including amyotrophic lateral sclerosis, progressive muscular atrophy, progressive bulbar palsy, and primary lateral sclerosis).

Ciliary neurotrophic factor, recombinant human

Treatment of squamous cell carcinoma of the head and neck.

Treatment of postherpetic neuralgia of the trigeminal nerve

Treatment of the chronic progressive form of multiple sclerosis.

Clazosentan Erajet 2/16/2006

Clindamycin Cleocin 10/28/1988

Clindamycin Cleocin 10/28/1988

Clindamycin hydrochloride Treatment of sarcoidosis 8/9/2006

clobazam Treatment of Lennox-Gastaut Syndrome. 12/18/2007

clofarabine Clofarex Treatment of acute myelogenous leukemia 3/14/2002

Clonazepam Klonopin Treatment of hyperekplexia (startle disease). 8/4/1994

Clonazepam Intranasal Spray Treatment of recurrent acute repetitive seizures 12/19/2007

Clostridial collagenase 5/23/1996

Clotrimazole Topical treatment of children and adults with pouchitis 6/14/2005

Clotrimazole Treatment of Huntington's disease 3/13/2006

Clotrimazole Treatment of sickle cell disease. 4/24/1995

Treatment of chronic myelogenous leukemia 2/22/2005

Treatment of cerebral vasospasm following subarachnoid hemorrhage

Prevention of Pneumocystis carinii pneumonia in AIDS patients.

Treatment of Pneumocystis carinii pneumonia associated with AIDS patients.

Treatment of advanced (involutional or residual stage) Dupuytren's disease.

c-myb antisense oligodeoxynucleotide

NovoSeven 6/18/2004

NovoSeven 6/18/2004

NovoSeven 10/3/2006

cobiprostone Treatment of cystic fibrosis 11/14/2002

coccidioidin SD Skin Test Antigen For the diagnosis of Coccidioidomycosis. 12/19/2007

Coenzyme Q10 Treatment of Huntington's disease 3/5/2001

Colchicine Treatment of familial Mediterranean fever 9/25/2007

Colchicine Treatment of Behcet's Syndrome 9/25/2007

Colchicine 12/9/1985

Plaquase Treatment of Peyronie's disease. 3/12/1996

Combretastatin A4 phosphate Treatment of ovarian cancer 5/8/2006

Combretastatin A4 Phosphate 7/23/2003

TransMID 12/3/2001

conjugated bile acids COBARTin 7/18/2003

Contulakin-G 7/7/2005

Coagulation factor VIIa (recombinant)

Prevention of bleeding episodes in Glanzmann's thrombasthenia

Coagulation factor VIIa (Recombinant)

Treatment of bleeding episodes in Glanzmann's thrombasthenia

Coagulation Factor VIIa (Recombinant)

Treatment of bleeding in patients experiencing intracranial hemorrhage.

For arresting the progression of neurologic disability caused by chronic progressive multiple sclerosis.

Collagenase (lyophilized) for injection

Treatment of anaplastic thyroid cancer, medullary thyroid cancer, and stage IV papillary or follicular thyroid cancer

conjugate of human transferrin and a mutant diphtheria toxin (CRM 107)

Treatment of malignant tumors of the central nervous system

Treatment of steatorrhea in patients with short bowel syndrome

Intrathecal treatment of neuropathic pain associated with spinal cord injury

Cordycepin Treatment of TdT-positive acute lymphocytic leukemia 7/5/2007

Xerecept Treatment of peritumoral brain edema. 4/6/1998

Coumarin Onkolox Treatment of renal cell carcinoma. 12/22/1994

Coxsackievirus A21 Cavatak 12/15/2005

Creatine Creapure Treatment of Huntington's disease 10/11/2005

creatine Creapure Treatment of amyotrophic lateral sclerosis 2/12/2002

Cry5B 9/5/2008

12/30/1991

8/15/2003

CY-1503 Cylexin 7/18/1997

CY-1503 Cylexin 12/22/1993

CY-1899 3/16/1994

12/20/2006

Cyclosporin A Mitogard 10/29/2004

Corticotropin-releasing factor, human

Treatment of stage II (T4), stage III, and stage IV melanoma

Treatment of soil transmitted helminth infection strongyloidiasis

Cryptosporidium hyperimmune bovine colostrum IgG concentrate

Treatment of diarrhea in AIDS patients caused by infection with Cryptosporidium parvum.

cultured, partially T-Cell depleted, allogenic thymic tissue for transplantation

As a therapy for primary immune deficiency resulting from athymia associated with complete DiGeorge Syndrome

Treatment of neonates and infants undergoing cardiopulmonary bypass during surgical repair of congenital heart lesions.

Treatment of post-ischemic pulmonary reperfusion edema following surgical treatment for chronic thromboembolic pulmonary hypertension.

Treatment of chronic active hepatitis B infection in HLA-A2 positive patients.Cyclo {{(E,Z)-(2S,3R,4R)-3-

hydroxy-4-methyl-2-(methylamino)nona-6,8-dienoyl}-L-2-aminobytyrl-N-methyl-glycyl-

Treatment and chronic control of non-infectious posterior, intermediate and pan-uveitis

Treatment of amyotrophic lateral sclerosis and its variants

cyclosporine Prophylaxis of graft-versus-host disease 2/17/2009

cyclosporine Treatment of graft-versus-host disease 2/17/2009

Cyclosporine Kristin Miller, CSO, HFD-590. 11/25/2003

Cyclosporine Pluminiq 11/25/2003

8/1/1991

8/1/1991

Cyclosporine A Treatment of vernal keratoconjunctivitis 5/4/2007

cyclosporine A Prevention of corneal graft rejection 9/30/2008

cyclosporine A NOVA22007 Treatment of herpes simplex virus stromal keratitis 4/9/2008

Cyclosporine A implant 1/8/2007

Prevention of solid organ graft rejection. 12/6/2000

Cyclosporine ophthalmic Optimmune 11/9/1988

Cyproterone acetate Androcur Treatment of severe hirsutism. 10/26/1984

Cys-His-Ala-Val-Cys 2/14/2008

Prophylaxis of organ rejection in patients receiving allogeneic lung transplant

Treatment of acute rejection in patients requiring allogenic lung transplants

Cyclosporine 2% ophthalmic ointment

Treatment of patients at high risk of graft rejection following penetrating keratoplasty.

Cyclosporine 2% ophthalmic ointment

For use in corneal melting syndromes of known or presumed immunologic etiopathogenesis, including Mooren's ulcer.

For the prevention of acute rejection in cornea transplant patients

Cyclosporine in combination with omega-3 polyunsaturated fatty acids

Treatment of severe keratoconjunctivitis sicca associated with Sjogren's syndrome.

For use in conjunction with melphalen for the treatment of malignant melanoma, AJCC stages IIB, IIC, III and IV

cysteamine 8/6/2008

cysteamine Treatment of Huntington's disease 5/9/2008

Cysteamine Treatment of nephropathic cystinosis. 5/1/1986

Cysteamine hydrochloride 8/19/1997

Cystic fibrosis gene therapy Treatment of cystic fibrosis. 6/30/1992

AdGVCFTR.10 Treatment of cystic fibrosis. 3/9/1995

1/14/1992

Treatment of cystic fibrosis. 1/8/1993

cytarabine liposome DepoCyt Treatment of gliomas 1/30/2007

Treatment of acute myeloid leukemia 8/22/2008

9/23/2006

6/3/2005

1/28/1991

Dantrolene sodium Dantrium Treatment of the neuroleptic malignant syndrome. 12/14/1987

Treatment of neuronal ceroid lipofuscinoses (Batten disease)

Treatment of corneal cystine crystal accumulation in cystinosis patients.

Cystic fibrosis Tr gene therapy (recombinant adenovirus)

Cystic fibrosis transmembrane conductance regulator

For cystic fibrosis transmembrane conductance regulator protein replacement therapy in cystic fibrosis patients.

Cystic fibrosis transmembrane conductance regulator gene

Cytarabine:daunorubicin liposome injectionCytomegalovirus DNA Vaccine w/Copolymer/Benzalkonium Chloride

For use in prevention of clinically significant CMV viremia, CMV disease and associated complications in at-risk hematopoietic cell transplant and solid organ transplant populations

Cytomegalovirus DNA vaccine with plasmids expressing pp65 and gB genes

Prevention of clinically significant cytomegalovirus (CMV) viremia, CMV disease and asociated complications in at-risk hematopoietic cell transplant and solid transplant populations

Cytomegalovirus immune globulin intravenous (human)

For use in conjunction with ganciclovir sodium for the treatment of cytomegalovirus pneumonia in bone marrow transplant patients.

Dapsone 11/7/1994

Dapsone USP Dapsone 1/8/1992

Dapsone USP Dapsone Prophylaxis for Pneumocystis carinii pneumonia. 12/24/1991

Daunorubicin liposomal Treatment of acute myeloid leukemia 9/5/2008

DEAE-rebeccamycin Treatment of bile duct tumors 3/1/2004

debrase Debridase 8/20/2003

Decitabine Dacogen Treatment of acute myeloid leukemia 8/4/2006

decitabine Treatment of sickle cell anemia 9/9/2002

Decitabine Treatment of chronic myelogenous leukemia. 3/8/1999

deferiprone Treatment of Friedreich's ataxia. 7/31/2008

deferiprone Ferriprox 12/12/2001

deferoxamine-starch conjugate Treatment of acute iron poisoning. 1/28/2005

defibrotide For the prevention of hepatic veno-occlusive disease. 1/8/2007

Defibrotide For the treatment of hepatic veno-occlusive disease 5/21/2003

Prophylaxis of toxoplasmosis in severely immunocompromised patients with CD4 counts below 100.

For the combination treatment of Pneumocystis carinii pneumonia in conjunction with trimethoprim.

Debridement of acute, deep dermal burns in hospitalized patients

Treatment of iron overload in patients with hematologic disorders requiring chronic transfusion therapy

Defibrotide Treatment of thrombotic thrombocytopenic purpura. 7/5/1985

Dehydroepiandrosterone 7/13/1994

Dehydroepiandrosterone (DHEA) Fidelin 8/19/2003

Treatment of serious burns requiring hospitalization. 1/29/1997

1/28/1997

Deslorelin Somagard 11/5/1987

Treatment of pemphigus vulgaris 10/26/2004

Dexamethasone Posurdex 9/11/1998

dexamethasone phosphate Treatment of corneal graft rejection. 12/2/2008

dexanabinol 8/11/2004

dextran 1 Treatment of cystic fibrosis 3/21/2003

Dextran 70 Dehydrex 3/5/1990

Dextran and deferoxamine Bio-Rescue Treatment of acute iron poisoning. 3/8/1991

Uendex For use as an adjunct to the treatment of cystic fibrosis. 10/5/1990

Treatment of systemic lupus erythematosus (SLE) and the reduction in the use of steroids in steroid-dependent SLE patients.

Replacement therapy in individuals with adrenal insufficiency

Dehydroepiandrosterone sulfate sodium

Dehydroepiandrosterone sulfate sodium

To accelerate the re-epithelialization of donor sites in those hospitalized burn patients who must undergo autologous skin grafting.

Desmoglein 3 synthetic peptide (PI-0824)

For use in posterior segment drug delivery system in the treatment of idiopathic intermediate uveitis.

For the attenuation or amelioration of the long-term neurological sequelae associated with moderate and severe traumatic brain injury

Treatment of recurrent corneal erosion unresponsive to conventional therapy.

Dextran sulfate (inhaled, aerosolized)

Dextran sulfate sodium Treatment of aquired immunodeficiency syndrome. 11/19/1987

DHA-paclitaxel Taxoprexin Treatment of pancreatic cancer 9/25/2001

DHA-paclitaxel Taxoprexin 5/1/2003

DHA-paclitaxel Taxoprexin Treatment of metastatic malignant melanoma 10/10/2002

Nutrineal (Peritoneal 6/11/1992

Diaziquone 11/10/1983

Dideoxyinosine Treatment of acquired immunodeficiency syndrome. 6/22/1988

Diethyldithiocarbamate Imuthiol Treatment of AIDS. 4/3/1986

4/14/2004

Diethylnorspermine (DENSPM) Treatment for hepatocellular carcinoma 5/25/2004

diferuloylmethane Treatment of cystic fibrosis 6/13/2003

difluprednate Durezol 9/30/2008

Digitoxin Treatment of cystic fibrosis 5/27/2005

digitoxin Treatment of soft tissue sarcomas 10/18/2001

digitoxin Treatment of ovarian cancer 11/2/2001

Treatment of adenocarcinoma of the stomach or lower esophagus

Dianeal peritoneal dialysis solution with 1.1% amino acids

For use as a nutritional supplement for the treatment of malnourishment in patients undergoing continuous ambulatory peritoneal dialysis.

Treatment of primary brain malignancies (grade III and IV astrocytomas).

diethylenetriaminepentaacetate (DPTA)

For treatment of patients with known or suspected internal contamination with plutonium, americium or curium to increase the rates of elimination.

Treatment of endogenous and traumatic anterior uveitis and panuveitis.

Digoxin immune fab(ovine) Digidote 3/11/1985

Eurartesim 1/8/2007

Dihydrotestosterone Androgel -DHT 2/5/1996

dimethyl sulfoxide 5/9/2008

Dimethyl sulfoxide 11/22/1994

Dimethyl sulfoxide Treatment of cutaneous manifestations of scleroderma. 6/6/1986

Dimethylsulfoxide 4/6/1998

Dimethylsulfoxide 4/15/1997

ALEC 7/28/1988

diphenylcyclopenone 6/13/2003

Immther 3/1/1990

Disodium clodronate Treatment of hypercalcemia of malignancy. 6/16/1993

Disodium clodronate tetrahydrate Bonefos 3/5/1990

Disodium silibinin dihemisuccinate Legalon 7/10/1986

D-mannitol and L-proline Prodarsan(r) Treatment of Cockayne syndrome 4/20/2009

Treatment of life-threatening acute cardiac glycoside intoxication manifested by conduction disorders, ectopic ventricular activity and (in some cases) hyperkalemia.

dihydroartemisinin and piperaquine

Treatment of uncomplicated malaria caused by "Plasmodium falciparum," Plasmodium vivax," Plasmodium malariae," or "Plasmodium ovale."

Treatment of weight loss in AIDS patients with HIV-associated wasting.

For use in combination with antimicrobial drugs for the treatment of drug resistant tuberculosisTreatment of increased intracranial pressure in patients with severe, closed-head injury, also known as traumatic brain coma, for whom no other effective treatment is available.

Treatment of palmar-plantar erythrodysethesia syndrome.

Topical treatment for the prevention of soft tissue injury following extravastion of cytotoxic drugs.

Dipalmitoylphosphatidylcholine /phosphatidylglycerol

Prevention and treatment of neonatal respiratory distress syndrome.

Treatment of chronic severe forms of alopecia areata (Alopecia Totalis [AT]/Alopecia Universalis [AU])

Disaccharide tripeptide glycerol dipalmitoyl

Treatment of pulmonary and hepatic metastases in patients with colorectal adenocarcinoma.

Treatment of increased bone resorption due to malignancy.

Treatment of hepatic intoxication by Amanita phalloides (mushroom poisoning).

DMP 777 6/4/1996

Treatment of ovarian cancer. 4/4/2005

Leuvectin Treatment of renal cell carcinoma. 4/28/2000

O-Vax Adjuvant therapy for the treatment of ovarian cancer 9/21/2000

docosahexanoic acid-paclitaxel Taxoprexin Treatment of hormone-refractory prostate cancer. 3/5/2001

Doripenem 7/16/2004

Dovitinib Treatment of multiple myeloma 10/3/2006

Treatment of esophageal carcinoma 10/7/2005

doxorubicin PIHCA nanoparticles Doxorubicin Transdru Treatment of hepatocellular carcinoma 3/14/2005

Treatment of gastric cancer 2/20/2008

PulmaDex Treatment of cystic fibrosis 10/23/2002

Treatment of melanoma, stages IIb through IV 3/19/2009

droxidopa 1/17/2007

Duramycin Treatment of cystic fibrosis. 12/11/1997

Therapeutic management of patients with lung disease attributable to cystic fibrosis.

DNA plasmid vector expressing human IL-12 geneDNA-lipid complex (DMRIE/DOPE)/plasmid vector (VCL-1102, Vical) expressing human interleukin-2

DNP-Modified autologous tumor vaccine

Treatment of bronchopulmonary infection in patients with cystic fibrosis who are colonized with Pseudomonas aeruginosa or Burkholderia cepacia.

Doxorubicin HCl with pluronic L-61 and pluronic F-127

doxorubicin with pluronics F-127 and L-61

D-peptide of the sequence AKRHHGYKRKFH - NH2D-Phe-Cys-Tyr-D-Trp-Lys-Cys-Thr-Nh2 (disulfide bridge: 2-6) acetate

Treatment of neurogenic symptomatic orthostatic hypotension in patients with primary autonomic failure, dopamine-beta-hydroxylase deficiency, and nondiabetic autonomic neuropathy.

Dynamine 10/16/1991

Dynamine Treatment of Lambert Eaton myasthenic syndrome. 2/5/1990

ecallantide Kalbitor Treatment of angioedema 2/4/2003

eculizumab Soliris(r) Treatment of atypical hemolytic uremic syndrome 4/29/2009

eculizumab 3/5/2001

Eculizumab Treatment of dermatomyositis 9/21/2000

Edotreotide OctreoTher 7/28/2005

efaproxiral 7/28/2004

Eflornithine Treatment of anaplastic glioma 9/29/2006

Eflornithine HCl Ornidyl 4/18/1986

Elcatonin Intrathecal treatment of intractable pain. 9/25/1995

Enadoline hydrochloride Treatment of severe head injury. 1/28/1997

BetaRx 7/5/1995

Treatment of hereditary motor and sensory neuropathy type I (Charcot-Marie-Tooth disease).

Treatment of idiopathic membranous glomerular nephropathy

Treatment of somatostatin receptor-positive neuroendocrine gastroenteropancreatic tumors

Adjunct to whole brain radiation therapy for the treatment of brain metastases in patients with breast cancer

Treatment of Pneumocystis carinii pneumonia in AIDS patients.

Encapsulated porcine islet preparation

Treatment of type I diabetic patients who are already on immunosuppression.

eniluracil Treatment of hepatocellular carcinoma 12/15/2005

Enisoprost 10/20/1989

Enisoprost 10/20/1989

Enteric-coated cysteamine Treatment of cystinosis 10/24/2006

enzastaurin Treatment of diffuse large B-cell lymphoma 3/4/2009

Enzastaurin Treatment of glioblastoma multiforme 9/19/2005

Epidermal growth factor (human) 10/5/1987

Epidermal growth factor (human) 3/6/1985

Epoetin alfa Treatment of myelodysplastic syndrome. 12/20/1993

Epoetin alpha Procrit 8/27/1987

Epoetin alpha Procrit Treatment of anemia of prematurity in preterm infants. 7/21/1988

Epoetin alpha Procrit 3/7/1989

Epoetin beta Marogen 10/22/1987

Epoprostenol Flolan 3/29/1984

For use in organ transplant patients to diminish the nephrotoxicity induced by cyclosporine.

For use with cyclosporine in organ transplant recipients to reduce acute transplant rejection.

For acceleration of corneal epithelial regeneration and the healing of stromal tissue in the condition of non-healing corneal defects.

For promotion of cutaneous wound healing in extreme burn treatment protocols.

Treatment of anemia associated with end stage renal disease.

Treatment of HIV associated anemia related to HIV infection or HIV treatment.

Treatment of anemia associated with end stage renal disease.

Replacement of heparin in patients requiring hemodialysis and who are at increased risk of hemorrhage.

Epoprostenol Cycloprostin 10/29/1984

epratuzumab Treatment of acute lymphoblastic leukemia 9/30/2008

epratuzumab LymphoCIDE Treatment of non-Hodgkin's lymphoma. 7/13/1998

Eprodisate Fibrillex Treatment of secondary amyloidosis 4/6/1999

12/27/2006

Erlotinib Hydrochloride Tarceva Treatment of malignant gliomas 7/18/2003

Erwinia L-asparaginase Erwinase Treatment of acute lymphocytic leukemia. 7/30/1986

Erwinia L-asparaginase 1/25/1985

11/19/1987

8/19/1987

Estradiol Gel EstroGel (r) 10/31/2006

Etanercept Enbrel Treatment of Wegener's granulomatosis. 4/6/1999

Ethanol gel Treatment of congenital lymphatic malformations 3/13/2006

Replacement of heparin in patients requiring hemodialysis and who are at increased risk of hemorrhage.

Epstein Barr Virus specific cytotoxic T lymphocytes

Prevention and treatment of EBV-post transplant lymphoproliferative disease after hematopoietic stem cell transplant or solid organ transplant.

For use as an alternative to E. coli asparaginase in those situations where repeat courses of asparaginase therapy for acute lymphoblastic leukemia are required or where allergic reactions force the discontinuance of

Erythropoietin (human, recombinant)

Treatment of anemia associated with end stage renal disease.

Erythropoietin (recombinant human)

Treatment of anemia associated with end stage renal disease.

Estrogen replacement therapy in females with Turner syndrome

Ethanol gel Treatment of congenital venous malformations 3/29/2006

Ethinyl Estradiol, USP Treatment of Turner's syndrome. 6/22/1988

Ethiofos 8/1/1989

Ethyl eicosapentaenoate Treatment of Huntington's disease. 4/6/2000

Etidronate disodium Didronel IV infusion 5/2/1991

Etidronate disodium Didronel IV Infusion 5/2/1991

Etiocholanedione Treatment of Prader-Willi syndrome. 5/7/1996

Etiocholanedione Treatment of aplastic anemia. 11/3/1995

everolimus 2/14/2008

Prochymal Treatment of acute graft versus host disease 12/14/2005

Exisulind 2/14/1994

Treatment of congenital FXIII deficiency 5/21/2003

11/6/2003

Use as a chemoprotective agent for cisplatin and cyclophosphamide in the treatment of ovarian cancer.

Prevention of degenerative metabolic bone disease occurring in patients who require long term (6 months or greater) total parenteral nutrition.

Treatment of degenerative metabolic bone disease occurring in patients who require long term (6 months or greater) total parenteral nutrition.

Treatment of gastroenteropancreatic neuroendocrine tumors

Ex vivo cultured adult human mesenchymal stem cells

For the suppression and control of colonic adenomatous polyps in the inherited disease adenomatous polyposis coli.

Factor XIII [A2] homodimer, recombinant DNA origin

Factor XIII [A2} homodimer, recombinant DNA origin

For the prophylaxis of bleeding associated with congential FXIII deficiency

Fibrogammin P Treatment of congenital factor XIII deficiency. 1/16/1985

Factor XIII, recombinant Treatment of congenital factor XIII deficiency. 4/22/1993

Fampridine Neurelan Relief of symptoms of multiple sclerosis. 6/2/1987

Fampridine Neurelan Treatment of chronic, incomplete spinal cord injury. 6/2/1997

Fenobam hydrochloride Treatment of fragile X syndrome 11/20/2006

fenretinide Treatment of Ewing's sarcoma family of tumors. 2/1/2007

Fenretinide Treatment of neuroblastoma 10/5/2005

6/26/2003

FIAU Adjunctive treatment of chronic active hepatitis B. 7/24/1992

Fibrinogen (human) 8/23/1995

9/5/1988

Fibronectin (plasma derived) 12/5/1988

Filgrastim Neupogen Treatment of myelodysplastic syndrome. 8/30/1990

Filgrastim Neupogen 9/3/1991

factor XIII concentrate (human), pasteurized

ferric hexacyanoferrate (II) "Prussian Blue"

Treatment of patients with known or suspected internal contamination with radioactive or non-radioactive cesium or thallium

For the control of bleeding and prophylactic treatment of patients deficient in fibrinogen.

Fibronectin (human plasma derived)

Treatment of non-healing corneal ulcers or epithelial defects which have been unresponsive to conventional therapy and the underlying cause has been eliminated.Treatment of non-healing corneal ulcers or epithelial defects which are unresponsive to conventional therapy and for which any infectious cause of the defect has been eliminated.

Treatment of patients with AIDS who, in addition, are afflicted with cytomegalovirus retinitis and are being treated with ganciclovir.

Floxuridine, FUDR Intraperitoneal treatment of gastric cancer. 12/22/2004

Fludarabine phosphate Fludara 4/18/1989

Flumecinol Zixoryn 1/15/1985

Flunarizine Sibelium Treatment of alternating hemiplegia. 1/6/1986

Fluorouracil Adrucil 2/6/1989

Fluorouracil 10/27/1989

Fluorouracil 4/18/1990

Fluorouracil Treatment of glioblastoma multiforme. 6/29/2000

Fluoxetine Prozac Treatment of autism. 4/30/1999

Fluoxetine Prozac 4/14/2004

fosfomycin/tobramycin 11/28/2008

Fructose-1,6-diphosphate Cordox 5/29/1998

Treatment of Ewing's sarcoma 9/22/2008

Treatment of idiopathic pulmonary fibrosis. 11/8/2007

Treatment and management of patients with non-Hodgkins lymphoma.

Treatment of hyperbilirubinemia in newborn infants unresponsive to phototherapy.

For use in combination with leucovorin for therapy of metastatic adenocarcinoma of the colon and rectum.

For use in combination with interferon alpha-2a, recombinant, for the treatment of esophageal carcinoma.

For use in combination with interferon alpha-2a, recombinant, for the treatment of advanced colorectal carcinoma.

Treatment of body dysmorphic disorder in children and adolescents

Treatment of pulmonary infections associated with cystic fibrosis.

Treatment of painful vaso-occlusive episodes associated with sickle cell disease.

Full Phosphorothioate Antisense Oligonucleotide against EWS-Fli-1 nanoparticles

Fully Human Anti-MCP-1/CCL2 Monoclonal Antibody

1/11/2006

G17DT Immunogen Treatment of gastric cancer 7/18/2002

G17DT Immunogen Treatment of adenocarcinoma of the pancreas 7/10/2002

Gabapentin Neurontin Treatment of amyotrophic lateral sclerosis. 7/5/1995

Gamma hydroxybutyrate 12/3/1987

Gamma-hydroxybutyric acid 1/22/1985

Gammalinolenic acid Treatment of juvenile rheumatoid arthritis. 7/27/1994

Ganaxolone Treatment of infantile spasms. 5/25/1994

Ganciclovir Virgan 3/22/2007

Gancyclovir 6/7/1985

Gangliosides as sodium salts Cronassial Treatment of retinitis pigmentosa. 11/17/1988

Gavilimomab Acute graft-versus-host disease (aGVHD) 11/20/2000

Treatment of chronic lymphocytic leukemia 2/4/2009

Trinam 10/24/2000

Fusion protein consisting of human immunoglobim G1 constant region Fc region fused to the human receptor binding

Treatment of X-linked hypohidrotic ectodermal dysplasia

Treatment of narcolepsy and the auxiliary symptoms of cataplexy, sleep paralysis, hypnagogic hallucinations and automatic behavior.

Treatment of narcolepsy and the auxiliary symptoms of cataplexy, sleep paralysis, hypnagogic hallucinations, and automatic behavior.

Treatment of acute herpetic keratitis (dendritic and geographic ulcers)

Treatment of severe human cytomegalovirus infections in specific immunosuppressed patient populations.

gene encoding chimeric CD40 ligandGene plasmid hVEGF165 driven by human cytomegalovirus, and [2,3-bis(oleoyl)propyl]trimethyl ammonium and dioleoyl

Prevention of complications due to neointimal hyperplasia disease in certain vascular anastomoses.

Tretament of malignant glioma 4/29/2002

Geneticin Treatment of amoebiasis. 6/6/2005

Septopal 1/31/1991

Gentamicin liposome injection Maitec 7/10/1990

glatiramer acetate Copaxone Treatment of amyothrophic lateral sclerosis (ALS). 11/14/2007

Glatiramer acetate for injection Copaxone Treatment of primary-progressive multiple sclerosis 6/5/2001

glucarpidase Voraxaze Treatment of patients at risk of methotrexate toxicity 8/19/2003

glufosfamide For treatment of pancreatic cancer. 9/18/2006

Glycafilin 8/22/2008

Glyceol 2/22/1990

Glyceryl tri (4-phenylbutyrate) Treatment of spinal muscular atrophy 5/24/2005

glyceryl tri (4-phenylbutyrate) 4/27/2009

Treatment of adrenoleukodystrophy. 2/14/1995

Glycopyrrolate 6/9/2006

genetically engineered herpes simplex virus (G207)

Gentamicin impregnated PMMA beads on surgical wire

Treatment of chronic osteomyelitis of post-traumatic, postoperative, or hematogenous origin.

Treatment of disseminated Mycobacterium avium-intracellulare infection.

Prevention of delayed graft function after solid organ transplantation

To decrease intracranial hypertension and/or alleviate cerebral edema in patients who may benefit from osmotherapy.

Maintenance treatment of patients with deficiencies in enzymes of the urea cycle

Glyceryl trioleate and glyceryl trierucate

Treatment of pathologic (chronic moderate to severe) drooling in pediatric patients

GMI-1070 2/17/2009

GNE Lipoplex Treatment of hereditary inclusion body myopathy-2 11/13/2008

Golimumab Treatment of chronic sarcoidosis 11/2/2004

Gossypol Treatment of cancer of the adrenal cortex. 10/22/1990

Gp100 adenoviral gene therapy Treatment of metastatic melanoma. 3/25/1997

Treatment of cystic fibrosis 8/27/2008

Leucomax 6/6/1989

Leucomax 5/4/1990

Leucomax Treatment of myelodysplastic syndrome. 8/7/1989

Leucomax 12/12/1989

Leucomax Treatment of neutropenia due to hairy cell leukemia. 5/3/1990

5/8/1990

Growth hormone releasing factor 8/7/1989

Guanethidine monosulfate Ismelin 1/6/1986

Guanfacine Tenex Treatment of fragile X syndrome. 8/5/1999

Treatment of vaso-occlusive crisis in patients with sickle cell disease.

granulocyte macrophage colony stimuling factor

Granulocyte macrophage-colony stimulating factor

Treatment of severe thermal injuries in patients with greater than 40% full or partial thickness burns.

Granulocyte macrophage-colony stimulating factor

Treatment of chronic lymphocytic leukemia to increase granulocyte count.

Granulocyte macrophage-colony stimulating factor

Granulocyte macrophage-colony stimulating factor

Treatment of neutropenia associated with bone marrow transplants.

Granulocyte macrophage-colony stimulating factor

Group B streptococcus immune globulin

Treatment of neonates for disseminated group B streptococcal infection.

For the long-term treatment of children who have growth failure due to a lack of adequate endogenous growth hormone secretion.

Treatment of moderate to severe reflex sympathetic dystrophy and causalgia.

Gusperimus Spanidin Treatment of acute renal graft rejection episodes. 6/27/1996

Halofuginone Stenorol Treatment of systemic sclerosis. 2/7/2000

CADI Mw Active tuberculosis 9/3/2004

CADI Mw 11/21/2002

Heme arginate Normosang Treatment of symptomatic stage of acute porphyria. 3/10/1988

Heme arginate Normosang Treatment of myelodysplastic syndromes. 3/1/1994

Hemin and zinc mesoporphyrin Hemex Treatment of acute porphyric syndromes. 12/20/1993

Treatment of cardiogenic shock 12/18/2007

Heparin Treatment of cystic fibrosis 11/3/2005

Heparin sodium Treatment of cystic fibrosis 6/29/2006

9/18/2006

Nabi-HB 3/8/1995

Civacir(tm) 11/14/2002

HepeX-B 7/15/2003

heat killed Mycobacterium w immunomodulator

heat killed mycobacterium w immunomodulator

Adjuvant to multi-drug therapy in the management of multibacillary leprosy

Hemoximer (pyridoxalated hemoglobin polyoxyethylene)

Heparin-binding epidermal growth factor-like growth factor

Prevention and treatment of necrotizing enterocolitis (NEC) in preterm infants with birth weight less than 1,500 grams

Hepatitis B immune globulin intravenous (human)

Prophylaxis against hepatitis B virus reinfection in liver transplant patients.

Hepatitis C virus immune globulin (human)

Prophylaxis of hepatitis C infection in liver transplant recipients.

For the prevention of hepatitis B virus (HBV) reinfection in patients who have received a liver transplantation

Herpes simplex virus gene Treatment of primary and metastatic brain tumors. 10/16/1992

Histamine Maxamine 2/1/2000

Histamine Ceplene 12/15/1999

Histrelin 5/3/1991

HIV neutralizing antibodies Immupath Treatment of acquired immunodeficiency syndrome. 3/24/1992

Allovectin-7 9/30/1999

homoharringtonine Treatment for chronic myelogenous leukemia 2/8/2002

HPA-23 Treatment of acquired immunodeficiency syndrome. 7/17/1985

1/12/2009

Hsp E7 Treatment of recurrent respiratory papillomatosis (RRP) 3/19/2001

Remitogen 11/28/2001

Treatment of glycogen storage disease type II. 9/10/1996

4/4/2005

Treatment of Hodgkin's disease 9/27/2004

For use as an adjunct to cytokine therapy in the treatment of malignant melanoma.

Adjunct to cytokine therapy in the treatment of acute myeloid leukemia.

Treatment of acute intermittent porphyria, hereditary coproporphyria, and variegate porphyria.

HLA-B7/Beta2M DNA Lipid (DMRIE/DOPE) Complex

Treatment of invasive and metastatic melanoma (Stages II, III, and IV).

HPV-16 cancer therapeutic trojan peptide vaccine

Treatment of HPV-16 expressing head and neck squamous cell carcinoma.

Hu1D10, humanized monoclonal antibody

For use in the treatment of 1D10+ B cell non-Hodgkin's lymphoma

Human acid precursor alpha-glucosidase, recombinantHuman alpha 2,6 sialyltransferase adenoviral gene therapy

Treatment of patients with invasive (malignant) brain and central nervous system tumors lacking alpha 2,6 sialyltransferase.

Human anti-CD30 monoclonal antibody

HuMax-CD4 Treatment of mycosis fungoides 8/13/2004

Treatment of multiple myeloma 7/29/2008

Treatment of patients with angiosarcoma 5/5/2005

12/1/2004

Treatment of systemic sclerosis 1/11/2002

Treatment of idiopathic pulmonary fibrosis 7/9/2004

Treatment of osteonecrosis 3/24/2008

human coagulation factor XI Hemoleven Treatment of severe congential Factor XI deficiency. 11/8/2007

12/20/2006

Human factor X Treatment of hereditary factor X deficiency 11/8/2007

human gammaglobulin 9/16/2002

human gammaglobulin Treatment of idiopathic inflammatory myopathies 11/14/2003

human gammaglobulin Treatment for juvenile rheumatoid arthritis 5/25/2001

Centovir 8/7/1989

human anti-CD4 monoclonal antibody

human anti-cellular adhesion molecule-1 monoclonal antibody

Human anti-integrin receptor av monoclonal antibodyhuman anti-integrin receptor avb3/avb5 monoclonal antibody

Treatment of patients with high-risk stage II, stage III, and stage IV malignant melanoma

human anti-transforming growth factor beta 1 monoclonal antibody

human anti-transforming growth factor-B1,2,3Human autologous bone-forming cell derived from bone marrow stem cells

Human cytomegalovirus immunoglobulin

Prevention of congenital cytomegalovirus (CMV) infection following primary CMV infection in pregnant women

Treatment of gastrointestinal disturbances (to include constipation, diarrhea, and abdominal pain) associated with regression-onset autism in pediatric patients.

Human IgM monoclonal antibody (C-58) To CMV

Prophylaxis of cytomegalovirus infections in bone marrow transplant patients.

Centovir 8/7/1989

Human immune globulin Xepol Treatment of post-polio syndrome 3/29/2006

Treatment of AIDS. 11/21/1989

3/25/1992

Hivig Treatment of HIV-infected pediatric patients. 1/4/1995

Treatment of CD30+ T-cell lymphoma 1/10/2006

6/3/2004

7/7/2005

11/2/2004

Aerumab 11 9/18/2006

Treatment of cryopyrin-associated periodic syndromes 12/18/2007

Treatment of pancreatic cancer 10/24/2006

Wilate 4/18/2007

Octaplex 2/1/2008

human recombinant fusion protein Treatment of hypophosphatasia 9/12/2008

Human IgM monoclonal antibody (C-58) To CMV

Treatment of cytomegalovirus infections in allogenic bone marrow transplant patients.

Human immunodeficiency virus immune globulin

Human immunodeficiency virus immune globulin

Treatment of HIV-infected pregnant women and infants of HIV-infected mothers.

Human immunodeficiency virus immune globulinHuman immunoglobin anti-CD30 monoclonal antibodyHuman immunoglobulin (IgG1k)antiCTLA-4 monoclonal antibody

Treatment of high risk Stage II, Stage III, and Stage IV melanoma

human leukocyte-derived cytokine mixture

Neoadjuvant therapy in patients with squamous cell carcinoma of the head and neck

Human monoclonal antibody against platelet-derived growth factor D

To slow the progression of IgA nephropathy and delay kidney failure in patients affected by the disease.

Human monoclonal antibody directed against serotype 011 Pseudomonas aeruginosa

Treatment of hospital acquired pneumonia caused by serotype 011 positive Pseudomonas aeruginosa

Human monoclonal antibody of the Ig1/k-isotype against human interleukin-1 beta

Human monoclonal antibody targeting CC-chemokine ligand 2Human plasma coagulation Factor VIII and human plasma von Willebrand Factor

Treatment of von Willebrand disease except for surgical and/or invasive procedures in patients with von Willebrand disease in whom desmopressin is either ineffective or contraindicated

Human prothrombin complex concentrate

Reversal of anticoagulation therapy in patients needing treatment of serious or life threatening bleeding and/or needing urgent surgery or invasive procedures

Treatment of pancreatic cancer 7/20/2006

Vaxsyn HIV-1 Treatment of AIDS. 11/20/1989

Treatment of retinitis pigmentosa 3/13/2006

Treatment of graft-versus-host disease. 11/13/1998

Treatment of recent-onset Type I diabetes 9/29/2006

3/21/2005

Humanized anti-human CD2 MAb MEDI-507 9/17/1998

Humanized anti-tac Zenapax 3/5/1993

humanized IgG2 antibody 7/22/2008

Treatment of systemic lupus erythematosus. 2/9/1999

9/12/2001

Treatment of ovarian cancer 6/16/2006

6/18/2008

hyaluronic acid 3/19/2002

Hydralazine 4/9/2004

Human telomerase reverse transcriptase peptide vaccine

Human T-lymphotropic virus type III Gp160 antigens

Human umbilical tissue-derived cells

Humanized anti-CD2 monoclonal antibody

Humanized anti-CD3 monoclonal antibodyhumanized anti-human CD16 monoclonal antibody Treatment of adult idiopathic thrombocytopenic purpura For the induction of donor-specific immunologic

unresponsiveness resulting in prophylaxis of organ rejection without the need for chronic immunosuppressive therapy, in patients receiving

Prevention of acute graft-vs-host disease following bone marrow transplantation.

Treatment of vaso-occlusive crisis in patients with sickle cell disease.

Humanized MAb (IDEC-131) to CD40L

humanized monoclonal antibody against Shiga-like toxin II

To prevent the development of or to decrease the incidence and severity of hemolytic uremic syndrome and associated sequelae of Shiga-like toxin-producing E. coli.

Humanized monoclonal antibody to the high affinity folate alpha receptorhumanized monocloncal antibody against human integrin alphaVbeta6

Treatment of fibrosis-associated chronic allograft nephropathy in kidney transplant patients.

Treatment of emphysema in patients due to alpha-1 antitrypsin deficiencyTreatment of severe intrapartum hypertension (diastolic blood pressure greater than or equal to 110 or systolic blood pressure greater than or equal to 160) associated with severe preeclampsia/eclampsia of pregnancy

DuoCort Treatment of adrenal insufficiency 6/18/2008

Hydroxocobalamin Treatment of acute cyanide poisoning 9/22/2000

Treatment of severe acute cyanide poisoning. 10/4/1985

hydroxyurea Treatment of pediatric patients with sickle cell anemia. 4/15/2005

Hypericin Treatment of glioblastoma multiforme. 8/3/2000

Hypericin Treatment of cutaneous T-cell lymphoma. 2/7/2000

I(131)-TM-601 (chlorotoxin) Treatment of malignant glioma 2/14/2002

Iboctadekin Treatment of renal cell carcinoma 6/3/2005

Ibuprofen i.v. solution Salprofen Prevention of patent ductus arteriosus. 10/29/1996

icatibant 5/5/2004

icatibant Treatment of angioedema 11/25/2003

Idarubicin Idamycin Treatment of chronic myelogenous leukemia. 12/2/1992

Idarubicin Idamycin Treatment of myelodysplastic syndromes. 12/1/1992

hydrocortisone modified release tabs

Hydroxycobalamin/sodium thiosulfate

Treatment of burn patients hospitalized with burn-induced edema

Idarubicin HCl for injection Idamycin 2/12/1991

idebenone Treatment of Leber's hereditary optic neuropathy. 10/31/2006

idebenone Treatment of Duchenne muscular dystrophy 2/16/2007

Idebenone Treatment of Friedreich's ataxia 3/25/2004

Idoxuridine Treatment of nonparenchymatous sarcomas. 4/8/1996

IDUA-HIRMAb fusion protein AGT-181 Treatment of mucopolysaccharidosis Type 1 (MPS) 1/10/2008

Ifosfamide Ifex Treatment of bone sarcomas 8/7/1985

Ifosfamide Ifex Treatment of soft tissue sarcomas. 8/7/1985

IL13-PE38QQR Treatment of malignant glioma 11/2/2001

Treatment of astrocytic glioma. 4/6/2000

Iloprost solution for infusion 9/21/1989

Iloprost solution for infusion Treatment of heparin-associated thrombocytopenia. 5/14/1990

Imciromab pentetate Myoscint 1/25/1989

imexon Amplimexon Treatment of ovarian cancer. 8/12/2005

Treatment of acute lymphoblastic leukemia in pediatric patients.

IL-4 Pseudomonas Toxin Fusion Protein (IL-4(38-37)-PE38KDEL)

Treatment of Raynaud's phenomenon secondary to systemic sclerosis.

Detecting early necrosis as an indication of rejection of orthotopic cardiac transplants.

Imexon Treatment of multiple myeloma. 11/8/1996

Imexon Treatment of pancreatic adenocarcinoma 11/1/2003

Imexon Treatment of metastatic malignant melanoma 8/3/2001

ELAD 7/16/2004

Omr-IgG-am (tm) 5%Treatment of the West Nile virus infection 3/17/2004

Carimune NF Treatment for Guillain Barre Syndrome 5/4/2004

Gammagard Liquid Treatment of multifocal motor neuropathy 7/20/2006

Immune Globulin Int Treatment of patients with acute myocarditis. 11/22/1993

Iveegam, Immuno Treatment of polymyositis/dermatomyositis. 10/13/1992

Iveegam, Immuno Treatment of juvenile rheumatoid arthritis. 12/16/1992

Vivaglobin P (propose 9/22/2004

Implitapide 8/13/2004

Implitapide 8/19/2004

5/12/1992

Immortalized human liver cells found in the extracorporeal liver assist device

Treatment of fulminant hepatic failure (acute liver failure)

Immune Globulin (Human) containing high titers of West Nile virus antibodies

Immune Globulin Intravenous (human)Immune globulin intravenous (human)

Immune globulin intravenous (human)

Immune globulin intravenous (human)

Immune globulin intravenous (human)

Immune Globulin Subcutaneous (Human)

Treatment of patients with primary immune deficiency (PID) that are intolerant to immune globulin intravenous (IGIV) due to severe adverse events or poor venous access

Treatment of homozygous familial hypercholesterolemia

Treatment of patients with Fredrickson type I or V hyperlipoproteinemia

Imported fire ant venom, allergenic extract

For skin testing of victims of fire ant stings to confirm fire ant sensitivity and if positive, for use as immunotherapy for the prevention of IgE-mediated anaphylactic reactions.

Inalimarev and falimarev Treatment of adenocarcinoma of the pancreas 1/10/2006

Myoscint To aid in the diagnosis of myocarditis. 8/7/1989

Hybri-ceaker 2/6/1990

Indium-111 pentetreotide NeuroendoMedix Treatment of neuroendocrine tumors 6/16/2006

infliximab Remicade Treatment of juvenile rheumatoid arthritis 10/23/2002

infliximab Remicade Treatment of giant cell arteritis 5/6/2003

Infliximab REMICADE 11/12/2003

Infliximab Remicade Treatment of chronic sarcoidosis 5/21/2003

INGN 201 ADVEXIN Treatment of head and neck cancer 1/27/2003

INH-A00021 Veronate 6/13/2001

inolimomab Leukotac Treatment of graft versus host disease 10/23/2002

Inosine pranobex Isoprinosine Treatment of subacute sclerosing panencephalitis. 9/20/1988

Interferon alfa-2a (recombinant) Roferon-A Treatment of renal cell carcinoma. 4/18/1988

Interferon alfa-2a (recombinant) Roferon-A 5/11/1990

Indium In 111 murine monoclonal antibody FAB to myosin

Indium In-111 altumomab pentetate

Detection of suspected and previously unidentified tumor foci of recurrent colorectal carcinoma.

Treatment of pediatric (0 to 16 years of age) ulcerative colitis

Reduction (prevention) of nosocomial bacteremia caused by staphylococci in very low birth weight infants.

For the treatment of metastatic malignant melanoma in combination with Teceleukin.

Interferon alfa-2a (recombinant) Roferon-A 5/2/1990

Interferon alfa-2a (recombinant) Roferon-A 5/14/1990

Interferon alfa-2a (recombinant) Roferon-A 10/27/1989

Interferon alfa-2b (recombinant) Intron A Treatment of acute hepatitis B. 11/17/1988

Interferon alfa-2b (recombinant) Intron A Treatment of primary malignant brain tumors. 5/13/1988

Interferon alfa-2b (recombinant) Intron A Treatment of carcinoma in situ of the urinary bladder. 8/10/1988

Interferon alfa-2b (recombinant) Intron A Treatment of invasive carcinoma of the cervix. 4/18/1988

Interferon alfa-2b (recombinant) Intron A Treatment of ovarian carcinoma. 8/3/1987

Interferon alfa-2b (recombinant) Intron A Treatment of chronic myelogenous leukemia. 6/22/1987

Interferon alfa-2b (recombinant) Intron A Treatment of metastatic renal cell carcinoma. 6/22/1987

Interferon alfa-2b (recombinant) Intron A Treatment of laryngeal (respiratory) papillomatosis. 8/17/1988

Interferon alfa-2b (recombinant) Intron A Treatment of chronic delta hepatitis. 5/4/1990

Interferon alfa-nl Wellferon 10/16/1987

Interferon alfa-nl Wellferon Treatment of AIDS related Kaposi's sarcoma. 8/25/1986

For the concomitant administration with Teceleukin for the treatment of metastatic renal cell carcinoma.

For the concomitant administration with fluorouracil for the treatment of advanced colorectal cancer.

For use in combination with fluorouracil for the treatment of esophageal carcinoma.

Treatment of human papillomavirus in patients with severe resistant/recurrent respiratory (laryngeal) papillomatosis.

Interferon beta (recombinant) R-IFN-beta 2/12/1991

Interferon beta (recombinant) r-HuIFN-beta 5/9/1991

Interferon beta (recombinant) r-HuIFN-beta 4/18/1991

Betaseron Treatment of acquired immunodeficiency syndrome. 11/15/1988

Interferon beta-1a Rebif 3/11/1996

interferon Beta-1a Avonex Treatment of juvenile rheumatoid arthritis. 10/14/1998

Treatment of acute non-A, non-B hepatitis. 7/24/1992

Interferon beta-1a (recombinant) r-HuIFN-beta 4/3/1991

Interferon beta-1a (recombinant) Rebif 12/2/1992

Interferon gamma Treatment of idiopathic pulmonary fibrosis 10/11/2007

interferon gamma-1b Actimmune Treatment of idiopathic pulmonary fibrosis 9/12/2002

Interferon gamma-1b Actimmune Treatment of renal cell carcinoma. 12/4/1995

Interferon-alfa-1b Treatment of multiple myeloma 4/17/2001

For hematopoietic potentiation in aplastic anemia. 6/17/1991

6/17/1991

For the systemic treatment of metastatic renal cell carcinoma.

For the intralesional and/or systemic treatment of AIDS-related Kaposi's sarcoma.

For the systemic treatment of cutaneous T-cell lymphoma.

Interferon beta, recombinant human

Treatment of patients with secondary progressive multiple sclerosis.

Interferon beta-1a (recombinant human)

For the systemic treatment of cutaneous malignant melanoma.

Treatment of symptomatic patients with AIDS including all patients with CD4 T-cell counts less than 200 cells per mm3.

Interleukin-1 alpha, human recombinant

Interleukin-1 alpha, human recombinant

For the promotion of early engraftment in bone marrow transplantation.

Antril Treatment of juvenile rheumatoid arthritis. 9/23/1991

Antril 10/16/1992

Interleukin-1 Trap 4/4/2005

Interleukin-2 Teceleukin 5/11/1990

Interleukin-2 Teleleukin Treatment of metastatic malignant melanoma. 2/6/1990

Interleukin-2 Teceleukin Treatment of metastatic renal cell carcinoma. 2/5/1990

Interleukin-2 Teceleukin 5/3/1990

5/20/1991

Interleukin-3, human, recombinant 9/30/1993

Intraoral fluoride releasing system IFRS 7/31/2001

Intravenous immune globulin VitiGam Treatment of Stage IIB to IV malignant melanoma 7/26/2007

Octagam Treatment of stiff-person syndrome 7/31/2008

iobenguane I 131 Treatment of neuroendocrine tumors 7/5/2007

Iobenguane I 131 Azedra Ultratrace Treatment of neuroendocrine tumors 1/18/2006

Iobenguane Sulfate I-123 OmaClear 10/17/2005

Interleukin-1 receptor antagonist, human recombinant

Interleukin-1 receptor antagonist, human recombinant

Prevention and treatment of graft versus host disease in transplant recipients.

Treatment of Still's disease including juvenile rheumatoid arthritis and adult-onset Still's disease

In combination with interferon alfa-2a for the treatment of metastatic malignant melanoma.

In combination with interferon alfa-2a for the treatment of metastatic renal cell carcinoma.

Interleukin-3 human (recombinant)

Promotion of erythropoiesis in Diamond-Blackfan anemia (congenital pure red cell aplasia).For sequential administration with sargramostim to accelerate neutrophil and platelet recovery in patients undergoing autologous bone marrow transplantation for the treatment of Hodgkin's disease or non-Hodgkin's

Prevention of dental caries due to radiation-induced xerostomia in patients with head and neck cancer

Intravenous immune globulin (human) 10%

For scintigraphic detection, localization and staging of neuroblastoma.

iobenguane sulfate I-123 OmaClear 10/21/2005

For use in adrenal cortical imaging. 8/1/1984

9/30/1988

9/30/1988

11/7/1988

Pentacea Treatment of small-cell lung cancer. 2/22/2000

Treatment of B-cell lymphoma. 11/2/1987

Immurait, Ll-2-I-131 Treatment of B-cell leukemia and B-cell lymphoma. 9/18/1989

9/30/1988

9/30/1988

11/7/1988

131IchTNT-1 2/12/1999

irofulven Treatment of renal cell carcinoma. 7/27/1999

irofulven Treatment of ovarian cancer. 7/6/1999

For the detection, localization, and staging of pheochromocytomas.

Iodine 131 6B-iodomethyl-19-norcholesterol

Iodine I 123 murine monoclonal antibody to alpha-fetoprotein

Detection of alpha-fetoprotein producing germ cell tumors.

Iodine I 123 murine monoclonal antibody to alpha-fetoprotein

Detection of hepatocellular carcinoma and hepatoblastoma.

Iodine I 123 murine monoclonal antibody to hCG

Detection of hCG producing tumors such as germ cell and trophoblastic cell tumors.Iodine I 131 bis(indium-

diethylenetriaminepentaacetic acid)tyrosyllysine/hMN-14 x m734 F(ab')2 bispecific monoclonal

Iodine I 131 Lym-1 Monoclonal Antibody

Iodine I 131 murine monoclonal antibody IgG2a to B cell

Iodine I 131 murine monoclonal antibody to alpha-fetoprotein

Treatment of alpha-fetoprotein producing germ cell tumors.

Iodine I 131 murine monoclonal antibody to alpha-fetoprotein

Treatment of hepatocellular carcinoma and hepatoblastoma.

Iodine I 131 murine monoclonal antibody to hCG

Treatment of hCG producing tumors such as germ cell and trophoblastic cell tumors.Iodine I-131 radiolabeled chimeric

MAb tumor necrosis treatment (TNT-1B)

Treatment of glioblastoma multiforme and anaplastic astrocytoma.

Isobutyramide Treatment of sickle cell disease and beta thalassemia. 5/25/1994

Isobutyramide Isobutyramide oral sol 12/18/1992

isofagomine tartrate Treatment of Gaucher disease 1/10/2006

Itraconazole suspension Topical treatment of fungal otitis externa (otomycosis) 10/30/2008

IV Sotalol So-Aqueous 7/25/2008

JAK tyrosine kinase inhibitor Treatment of myelofibrosis 9/5/2008

Prevention of Japanese encephalitis. 5/19/1999

Ketoconazole Nizoral 3/27/1991

3/17/2009

Procysteine Treatment of adult respiratory distress syndrome. 6/14/1994

Procysteine Treatment of amyotrophic lateral sclerosis. 7/30/1996

L-5-hydroxytryptophan Treatment of tetrahydrobiopterin deficiency. 1/20/1999

Lactic acid Aphthaid 6/29/1999

Treatment of active chronic pouchitis 1/15/2002

1/15/2002

Treatment of beta-hemoglobinopathies and beta-thalassemia syndromes.

For ventricular tachycardia, ventricular fibrillation, or the maintenance of sinus rhythm in patients converted from atrial fibrillation or atrial flutter when oral administration is not possible.

Japanese encephalitis vaccine (live, attenuated) For use with cyclosporine A to diminish the

nephrotoxicity induced by cyclosporine in organ transplantation.

kit for the preparation of technetium Tc99m sulfur colloid

For localization of sentinel lymph nodes in patients with melanoma.

L-2-oxothiazolidine-4-carboxylic acid

L-2-oxothiazolidine-4-carboxylic acid

Treatment of severe aphthous stomatitis in severely, terminally immunocompromised patients.

lactic acid bacteria (Lactobacilli, Bifidobacteria, and Steptococci)lactic acid bacteria (Lactobacilli, Bifidobacteria, and Streptococcus species)

Prevention of disease relapse in patients with chronic pouchitis

Lactobin Lactobin 9/12/1990

1/18/2006

laromustine Onrigin Treatment of acute myelogenous leukemia 10/21/2004

Latrodectus immune F(ab)2 Aracmyn Treatment of black widow spider envenomations 6/18/2001

L-baclofen Treatment of trigeminal neuralgia. 7/13/1990

L-Baclofen Neuralgon 1/30/1992

L-baclofen Neuralgon 12/17/1991

L-Baclofen Treatment of trigeminal neuralgia. 1/6/1998

L-cycloserine Treatment of Gaucher's disease. 8/1/1989

L-cysteine 5/16/1994

Leflunomide 10/18/1996

lenalidomide Revlimid(r) Treatment of mantle cell lymphoma 4/27/2009

lenalidomide Revlimid Treatment of chronic lymphocytic leukemia. 1/17/2007

Treatment of AIDS-associated diarrhea unresponsive to initial antidiarrheal therapy.

L-aminocarnityl-succinyl-leucyl-argininal-diethylacetal

Treatment of Duchenne and Becker muscular dystrophy

Treatment of intractable spasticity in children with cerebral palsy.

Treatment of intractable spasticity associated with spinal cord injury or multiple sclerosis.

For the prevention and lessening of photosensitivity in erythropoietic protoporphyria.

Prevention of acute and chronic rejection in patients who have received solid organ transplants.

Thalagen 1/11/2006

Lestaurtinib Treatment of acute myeloid leukemia 3/24/2006

Leucovorin calcium Wellcovorin 6/23/1988

leukocyte interlukin Multikine 5/4/2007

Leupeptin 9/18/1990

Treatment of vernal keratoconjunctivitis. 2/29/1988

Levocarnitine Carnitor 11/24/1986

Levocarnitine Carnitor 11/15/1989

Levocarnitine Carnitor 11/15/1989

Levocarnitine Carnitor 4/7/1997

Levocarnitine Carnitor Treatment of pediatric cardiomyopathy. 11/22/1993

Levodopa and carbidopa Duodopa Treatment of late stage Parkinson's disease. 1/18/2000

Levofloxacin 2/27/2008

L-glutamine Treatment of sickle cell disease 8/1/2001

L-glutamyl-L-tryptophan Treatment of AIDS-related Kaposi's sarcoma. 10/20/1999

Lentiviral vector encoded with a human beta-globin gene plasmid

Treatment of beta-thalassemia major and beta-thalassemia intermedia

For use in combination with 5-fluorouracil for the treatment of metastatic colorectal cancer.

Neoadjuvant therapy in patients with squamous cell carcinoma of the head and neck

For use as an adjunct to microsurgical peripheral nerve repair.

Levocabastine HCl ophthalmic suspension 0.05% Treatment of manifestations of carnitine deficiency in

patients with end stage renal disease who require dialysis.

For the treatment of secondary carnitine deficiency in valproic acid toxicity.

For the prevention of secondary carnitine deficiency in valproic acid toxicity.

Treatment of zidovudine-induced mitochondrial myopathy.

Treatment of pulmonary infections due to Pseudomonas aeruginosa and other bacteria in patients with cystic fibrosis patients

liarozole The treatment of congenital ichthyosis 6/18/2004

Lintuzumab Treatment of myelodysplastic syndrome 3/20/2007

lintuzumab Treatment of acute myeloid leukemia. 1/30/2007

lintuzumab Zamyl Treatment of acute myelogenous leukemia 9/9/2002

Treatment of cystic fibrosis. 4/8/1996

Liposomal amphotericin B AmBisome Treatment of histoplasmosis. 12/10/1996

Liposomal annamycin Treatment of acute myeloid leukemia 6/17/2005

Liposomal annamycin Treatment of acute lymphoblastic leukemia 6/17/2005

Liposomal ciprofloxacin Management of bronchiectasis 12/27/2006

Management of cystic fibrosis 4/19/2006

Liposomal cisplatin LipOva-Pt Treatment of ovarian cancer 5/23/2006

Liposomal cyclosporin A Cyclospire 4/30/1998

Prevention of bronchiolitis obliterans. 6/24/2008

Sarcodoxome Treatment of soft tissue sarcomas 12/27/2006

liposomal gadodiamide Treatment of glioma. 11/12/2008

Lipid/DNA human cystic fibrosis gene

Liposomal ciprofloxacin for inhalation

For aerosolized administration in the prevention and treatment of lung allograft rejection and pulmonary rejection events associated with bone marrow transplantation.

liposomal cyclosporine for inhalation

Liposomal doxorubicin hydrochloride

ImmTher Treatment of osteosarcoma. 6/10/1998

ImmTher Treatment of Ewing's sarcoma. 6/10/1998

Liposomal nystatin Nyotran Treatment of invasive fungal infections. 6/13/2000

Treatment of chronic myelogenous leukemia 12/5/2003

Treatment of acute respiratory distress syndrome. 4/25/1996

liposomal topotecan hydrochloride Treatment of gliomas 10/30/2008

Aroplatin Treatment of malignant mesothelioma. 9/1/1999

Treatment of brain and CNS tumors. 11/25/1991

Treatment of cancers of the kidney and renal pelvis 6/20/1994

Lisofylline 6/10/1999

L-leucovorin Isovorin 12/18/1990

Loxoribine Treatment of common variable immunodeficiency. 2/24/1992

L-threonine 7/24/1992

Liposomal N-Acetylglucosminyl-N-Acetylmuramly-L-Ala-D-isoGln-L-Ala -gylcerolidpalmitoylLiposomal N-Acetylglucosminyl-N-Acetylmuramly-L-Ala-D-isoGln-L-Ala -gylcerolidpalmitoyl

liposomal p-ethoxy growth receptor bound protein-2 antisense product

Liposomal prostaglandin E1 injection

Liposomal-cis-bis-neodecanoato-trans-R,R-1,2-diaminocyclohexane-Pt (II)

Liposome encapsulated recombinant interleukin-2

Liposome encapsulated recombinant interleukin-2

Treatment of patients undergoing induction therapy for acute myeloid leukemia.

For use in combination chemotherapy with the approved agent 5-fluorouracil in the palliative treatment of metastatic adenocarcinoma of the colon and rectum.

Treatment of spasticity associated with familial spastic paraparesis.

L-threonine Threostat Treatment of amyotrophic lateral sclerosis. 2/6/1989

4/26/2005

L-tyrosine-L-serine-L-leucine CMS-024 Treatment of hepatocellular carcinoma. 9/10/2004

Lucinactant Surfaxin 5/23/2006

Lucinactant Surfaxin 10/21/2005

Lucinactant Surfaxin 7/30/1996

Lucinactant Surfaxin 7/17/1995

Lucinactant Surfaxin 10/18/1995

Lysine acetylsalicylate injectable 8/1/1989

9/10/2008

ThermoDox (r) For treatment of hepatocellular carcinoma. 3/17/2009

macitentan Treatment of idiopathic pulmonary fibrosis. 4/14/2009

Mafosfamide Treatment of neoplastic meningitis 1/21/2003

11/24/2008

L-threonyl-L-prolyl-L-prolyl-L-threonine

Treatment of neuropathic pain associated with spinal cord injury

Prevention of bronchopulmonary dysplasia in premature infants

Treatment of bronchopulmonary dysplasia in premature infants.

Treatment of meconium aspiration syndrome in newborn infants

Treatment of acute respiratory distress syndrome in adults.

Treatment of respiratory distress syndrome in premature infants.

Treatment of pain and fever secondary to sickle cell disease crisis.

lysosomal enzyme N-acetylgalactosamine-6-sulfate sulfatase

Treatment of mucopolysaccharidosis Type IVA (Morquio Syndrome)

lyso-thermosensitive lipsomal doxorubicin

MAGE-A3 cancer therapeutic Trojan peptide vaccine

Treatment of MAGE-A3 expressing head and neck squamous cell carcinoma

Treatment of soft tissue sarcoma 8/12/2005

2/27/2008

Mannitol Bronchitol 2/11/2005

4/27/2004

maribavir 2/1/2007

Marijuana Treatment of HIV-associated wasting syndrome. 5/25/1999

Matrix metalloproteinase inhibitor Galardin Treatment of corneal ulcers. 12/5/1991

MaxAdFVIII Treatment of Hemophilia A 3/3/2003

Mazindol Sanorex Treatment of Duchenne muscular dystrophy. 12/8/1986

Mecamylamine Inversine Treatment of Tourette's syndrome. 10/14/1998

mecasermin Iplex Treatment of myotonic dystrophy 12/3/2007

Mecasermin Myotrophin Treatment of amyotrophic lateral sclerosis. 8/5/1991

Treatment of mycosis fungoides. 8/12/2004

MEDI-522 Vitaxin 4/14/2004

Mammalian target of rapamcyin (mTOR) inhibitor

Manganese superoxide dismutase mimetic

Prevention of radiation- or chemotherapy-induced oral mucositis in cancer patients

For use to facilitate clearance of mucus in patients with bronchiectasis and in patients with cystic fibrosis at risk for bronchiectasis

mannopentaose phosphate sulfate

Treatment of high-risk Stage II, Stage III, and Stage IV melanoma

Prevention of cytomegalovirus viremia and disease in the populations at risk.

meclorethamine or nitrogen mustard

For the treatment of of stage IIb, stage IIc, stage III and stage IV melanoma

Medroxyprogesterone acetate Hematrol Treatment of immune thrombocytopenic purpura. 2/22/2001

Mefloquine HCl Mephaquin Prevention of chloroquine-resistant Falciparum malaria. 7/22/1987

Mefloquine HCl Mephaquin Treatment of chloroquine-resistant Falciparummalaria. 7/22/1987

9/6/2006

Melanoma cell vaccine Canvaxin Treatment of invasive melanoma. 10/13/1994

Melanoma peptide vaccine 3/29/2005

Melanoma vaccine Melacine Treatment of stage III - IV melanoma. 12/20/1989

Melatonin Circadin 7/9/2004

Melatonin 11/15/1993

melphalan 11/24/2008

Melphalan Alkeran for Injection 3/3/1992

melphalan hydrochloride Treatment of patients with ocular (uveal) melanoma. 11/12/2008

melphalan hydrochloride Treatment of patients with cutaneous melanoma. 11/12/2008

mepivacaine Treatment of postherpetic neuralgia 1/8/2007

Melanoma autologous dendritic cell vaccine

Treatment of stage IIIb through IV metastatic melanoma

Treatment of HLA-A2+ patients with stage IIB, IIC, III, and IV malignant melanoma

Treatment of non-24-hour sleep-wake disorder in blind individuals without light perception

Treatment of circadian rhythm sleep disorders in blind people with no light perception.

High dose conditioning treatment prior to hematopoietic progenitor (stem) cell transplantation

For use in hyperthermic regional limb perfusion to treat metastatic melanoma of the extremity.

Mepivacaine Treatment of painful HIV-associated neuropathy 10/18/2006

mepolizumab 5/28/2004

Meropenem Merrem IV 4/27/2000

mesalamine; 5-aminosalicylic acid Lialda 2/27/2008

Mesna 12/16/1987

Methionine/L-methionine Treatment of AIDS myelopathy. 8/21/1996

methotrexate Rheumatrex Treatment of juvenile rheumatoid arthritis. 8/23/1993

Methotrexate with laurocapram Methotrexate/azone Topical treatment of mycosis fungoides. 10/15/1990

Methoxsalen Uvadex 10/14/1998

metreleptin 8/22/2001

metreleptin 8/22/2001

metronidazole Treatment of pouchitis 9/17/2008

Metronidazole Metrogel Treatment of perioral dermatitis. 10/24/1991

For first-line treatment in patients with hypereosinophilic syndrome

Management of acute pulmonary exacerbations, in cystic fibrosis patients, due to respiratory tract infection with susceptible organisms.

Treatment of active, mild to moderate ulcerative colitis in children 5 to 17 years

Inhibition of the urotoxic effects induced by oxazaphosphorine compounds such as cyclophosphamide.

For use in conjunction with the UVAR photopheresis system to treat graft versus host disease.

Treatment of metabolic disorders secondary to lipodystrophy

Treatment of leptin deficiency secondary to generalizedlipodystrophy and partial familial lipodystrophy

Metronidazole (topical) Flagyl 11/24/1987

Metronidazole 10% ointment Topical treatment of active perianal Crohn's disease 11/8/2007

metyrosine Demser 7/25/2008

mibefradil Treatment of pancreatic cancer. 10/16/2008

Mibefradil Treatment of ovarian cancer 6/15/2007

Microbubble contrast agent Filmix Neurosonograp 11/16/1990

10/11/2007

1/25/2007

Midazolam HCl 5/8/2006

mifamuritide Junovan Treatment of osteosarcoma 6/5/2001

Mifepristone 2/7/2005

mifepristone Corlux 7/5/2007

miglustat Zavesca (r) 11/12/2008

milatuzumab Treatment of chronic lymphocytic leukemia. 6/24/2008

Treatment of grade III and IV, anaerobically infected, decubitus ulcers.

Treatment of velocardiofacial syndrome associated psychosis.

Intraoperative aid in the identification and localization of intracranial tumors.

Microvesiculated modified glycosylated tissue factor

Treatment of cutaneous bleeding episodes in patients with von Willebrand disease.

Microvesiculated modified glycosylated tissue factor

Treatment of non-life threatening, mild to severe bleeding episodes due to cutaneous injuries or dental procedures in hemophiliac patientsTreatment of bouts of increased seizure activity in selected refractory patients with epilepsy who are on stable regimens of anti-epileptic drugs and who require intermittent use of midazolam

Treatment of Cushing's syndrome secondary to ectopic ACTH secretion

Treatment of the clinical manifestations of endogenous Cushing's symdrome.

Treatment of the neurological manifestations of Niemann-Pick disease,type C.

milatuzumab Treatment of multiple myeloma 3/10/2008

miltefosine Miltex(r) / Impavido(r 3/18/2009

miltefosine Impavido Treatment of leishmaniasis. 10/10/2006

Minocycline HCl Minocin Intravenous Treatment of chronic malignant pleural effusion. 6/19/1992

Minocycline hydrochloride Treatment of sarcoidosis 3/28/2006

misoprostol GyMiso 1/10/2005

Mitoguazone apep 3/18/1994

Mitolactol 1/23/1989

Mitolactol 7/12/1995

mitomycin-C Trabomycin 1/8/2008

Mitomycin-C 8/20/1993

Cea-Cide Treatment of small cell lung cancer 9/18/1998

Cea-Cide Treatment of pancreatic cancer. 11/24/1998

Molgramostim Leucomax 1/24/1989

Topical treatment of cutaneous lymphoma encompassing cutaneous manifestations of T-cell lymphoma and B-cell lymphoma

Treatment of intrauterine fetal death not accompanied by complete expulsion of the products of conception in the second and third trimesters of pregnancy.Treatment of diffuse non-Hodgkin's lymphoma, including AIDS-related diffuse non-Hodgkin's lymphoma.

Treatment of invasive carcinoma of the uterine cervix

As adjuvant therapy in the treatment of primary brain tumors.

Treatment of refractory glaucoma as an adjunct to ab externo glaucoma surgery.

Treatment of refractory glaucoma as an adjunct to ab externo glaucoma surgery.

MN14 monoclonal antibody to carcinoembryonic antigen

MN14 monoclonal antibody to carcinoembryonic antigen

Treatment of AIDS patients with neutropenia due to the disease, AZTor ganciclovir.

Molgramostim Leucomax Treatment of aplastic anemia. 9/25/1989

monarsen Treatment of Myasthenia Gravis 11/14/2003

Melimmune Treatment of invasive cutaneous melanoma. 9/19/1994

Treatment of B-cell lymphoma. 5/6/1986

Monoclonal antibody 17-1a Panorex Treatment of pancreatic cancer. 4/4/1988

monoclonal antibody 3F8 Treatment of neuroblastoma 9/16/2008

Treatment of lupus nephritis. 1/7/1993

11/15/1991

9/13/1991

6/17/1991

Monoclonal antibody-B43.13 Ovarex MAb-B43.13 Treatment of epithelial ovarian cancer. 11/25/1996

11/4/1985

Monolaurin Glylorin Treatment of congenital primary ichthyosis. 4/29/1993

motexafin gadolinium Xcytrin 1/27/2003

Monoclonal Ab(murine) anti-idiotype melanoma-associated antigen

Monoclonal antibodies (murine or human) to B-cell lymphoma

Monoclonal antibody for immunization against lupus nephritis

Monoclonal antibody to cytomegalovirus (human)

Treatment of cytomegalovirus retinitis in patients with AIDS.

Monoclonal antibody to cytomegalovirus (human)

Prophylaxis of cytomegalovirus disease in patients undergoing solid organ transplantation.

Monoclonal antibody to hepatitis B virus (human)

Prophylaxis of hepatitis B reinfection in patients undergoing liver transplantation secondary to end-stage chronic hepatitis B infection.

Monoclonal antiendotoxin antibody XMMEn-0e5

Treatment of patients with gram-negative sepsis which has progressed to shock.

For use in conjunction with whole brain radiation for the treatment of brain metastases arising from solid tumors

MTC-DOX for Injection Treatment of hepatocellular carcinoma 1/3/2001

MEP IGIV 1/9/1991

MEP IGIV 11/7/1990

7/27/2004

12/12/1989

Oncolym Treatment of B-cell non-Hodgkin's lymphoma. 11/27/1998

Theragyn Adjuvant treatment of ovarian cancer. 3/22/1999

Mx-dnG1 Rexin-G(R) Treatment for soft tissue sarcoma. 6/24/2008

Mx-dnG1 Rexin-G Treatment of osteosarcoma. 6/24/2008

REXIN-G Treatment of pancreatic cancer 8/15/2003

10/11/1995

Mycophenolate mofetil CellCept Treatment of pemphigus vulgaris 5/26/2006

Myelin Treatment of multiple sclerosis. 6/27/1991

myo-inositol 4/7/2005

Mucoid exopolysaccharide Pseudomonas hyperimmune globulin

Treatment of pulmonary infections due to Pseudomonas aeruginosa in patients with cystic fibrosis.Mucoid exopolysaccharide

Pseudomonas hyperimmune globulin

Prevention of pulmonary infections due to Pseudomonas aeruginosa in patients with cystic fibrosis.

Multi-ligand somatostatin analogue

Treatment of patients with functional gastroenteropancreatic (GEP) neuroendocrine tumors (specifically, carcinoid, insulinoma, gastrinoma, somastatinoma, GRFoma, VIPoma and glucagonoma.

Multi-vitamin infusion (neonatal formula)

For establishment and maintenance of total parenteral nutrition in very low birth weight infants.Murine MAb (Lym-1) and Iodine

131-I radiolabeled murine MAb (Lym-1) to human B-cell lymphomaMurine MAb to polymorphic epithelial mucin, human milk fat globule 1

Mx-dnG1 or Rexin-G retroviral vector

Mycobacterium avium sensitin RS-10

For use in the diagnosis of invasive Mycobacterium avium disease in immunocompetent individuals.

Prevention of retinopathy of prematurity in preterm infants at risk for developing retinopathy of prematurity

APT070 5/21/2003

Treatment of malignant gastrointestinal stromal tumors. 4/20/2005

10/23/2007

Treatment of gastrointestinal stromal tumors 1/13/2005

Treatment of patients with cystic fibrosis. 12/20/2006

Treatment of Hodgkin's lymphoma 8/8/2007

Treatment of acute myeloid leukemia 2/1/2008

Treatment of acute myeloid leukemia 3/18/2009

Treatment of multiple myeloma. 10/17/2005

Treatment of neuroblastoma 9/30/2004

12/27/2006

Treatment of acute myelogenous leukemia 10/23/2007

Treatment of hepatocellular carcinoma 5/23/2007

Treatment of stages IIB-IV melanoma 8/13/2004

Treatment of cutaneous T-cell lymphoma 3/24/2006

myristoylated recombinant SCR1-3 of human complement reseptor type I

Prevention of delayed graft function in solid organ transplantN-((methyl-diazacyclohexyl-

methylbenzamide)-asaphenyl-aminothiopyrrole) mesylateN-(2,2,2-trifluoroethyl)-9-[4-[4-[[[4'-(trifluoromethyl)[1,1'biphenyl]-2-yl]carbonyl]amino]-1-piperidinyl]butyl]-9H-fluorene-9-

Treatment of homozygous familial hypercholesterolemiaN-(2,3-dihydro-3,3-dimethyl-1H-

indol-6-yl)-2-[(4-pyridinylmethyl)amino]-3-pyridinecarboxamide, phosphate N-(2,4-Di-tert-butyl-5-hydroxyphenyl)-1,4-dihydro-4-oxoquinoline-3-carboxamideN-(2-amino-phenyl)-4-[(4-pyridin-3-yl-pyrimidin-2-ylamino)-methyl] benzamide dihydrobromideN-(2-amino-phenyl)-4-[(4-pyridin-3-yl-pyrimidin-2-ylamino)-methyl] benzamide dihydrobromideN-(5-tert-Butylisoxazol-3-yl)-N'-{4-[7-(2-(morpholin-4-yl)ethoxy) imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea di-hydrochloride

N-(methyl-diazacyclohexyl-methylbenzamide)-azaphenyl-aminothiopyrrole) mesylateN-[2-[(4-hydroxyphenyl)amino]-3-pyridinyl]-4-methoxybenzenesulfonamideN-[3-(4',5'-bipyrimidin-2-ylamino)-4-methylphenyl]-4-{[(3S)-3-(dimethylamino)pyrrolidin-1-yl]methyl}-3-

Treatment of Philadelphia chromosome-positive chronic myelogenous leukemia.

N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N1-(2-fluoro-5-methylphenyl) ureaN-[4-(3-amino1H-indazol-4-yl)phenyl]-N1-(2-fluoro-5-methylphenyl)ureaN-[4-(4-amino-2-ethyl-1H-imidazo[4,5-c]quinolin-1-yl)butyl]methanesulfonamideN-[4-(4-amino-2-ethyl-lH-imidazo[4,5-c]quinolin-1-yl)butyl]methanesulfonamide

Treatment of sickle cell disease 5/13/2002

Treatment of multiple myeloma 2/27/2008

nabumetone For treatment of pediatric juvenile rheumatoid arthritis. 5/5/2008

N-acetylcysteinate Lysine Nacystelyn Dry PowdeFor the management of cystic fibrosis 12/27/2000

N-acetylcysteine Treatment of acute liver failure 9/9/2002

N-acetyl-glucosamine thiazoline Treatment of adult Tay-Sachs disease 2/6/2006

N-acetylprocainamide Napa 3/23/1990

N-acetyl-procainamide 12/10/1996

Treatment of soft tissue sarcoma 12/9/2003

Treatment of tuberculosis. 10/16/2007

Treatment of polycythemia vera 11/18/2002

Treatment of Behcet's disease. 1/18/2000

8/10/2000

NDROGE Treatment of postanoxic intention myoclonus. 11/1/1984

N-[4-bromo-2-(1H-1,2,3,4-tetrazol-5-yl)phenyl]-N'-[3,5-bis(trifluoromethyl)phenyl]ureaN2'-Deacetyl-N2'-[4-methyl-4-(oxobuthyldithio)-1-oxopentyl]-maytansine-chimerized anti-CD138 IgG4 Monoclonal Antibody

To lower the defibrillation energy requirement sufficiently to allow automatic implantable cardioverter defibrillator therapy in those patients who could otherwise not use the device.

Prevention of life-threatening ventricular arrhythmias in patients with documented procainamide-induced lupus.N-acetyl-sarcosyl-glycyl-L-valyl-D-

alloisoleucyl-L-threonyl-L-norvalyl-L-isoleucyl-L-arginyl_L-prolylethylaminde acetate

N-adamantanyl-N'-Geranyl-ethylenediamine

natural human lymphoblastoid interferon-alpha

Natural human lymphoblastoid interferon-alpha

Natural human lymphoblastoid interferon-alpha

Treatment of papillomavirus warts in the oral cavity of HIV positive patients.

Nebacumab Centoxin 10/1/1986

Neurotrophin-1 9/13/1994

NG-29 Somatrel 8/8/1989

Nifedipine Treatment of interstitial cystitis. 6/13/1991

Nikkomycin Z Treatment of coccidioidomycosis 2/14/2006

nilotinib Tasigna Treatment of gastrointestinal stromal tumors. 3/20/2007

Nimotuzumab Treatment of glioma 11/17/2004

niprisan Hemoxin Treatment of sickle cell disease 8/15/2003

nitazoxanide Cryptaz Treatment for intestinal amebiasis 10/23/2001

Nitisinone Orfadin Treatment of alkaptonuria 10/19/2001

nitric oxide INOmax (r) 9/5/2008

Nitric oxide Diagnosis of sarcoidosis 2/16/2005

Nitric oxide INOmax 9/27/2004

Nitric oxide 7/10/1995

Treatment of patients with gram-negative bacteremia which has progressed to endotoxin shock.

Treatment of motor neuron disease/amyotrophic lateral sclerosis.

Diagnostic measure of the capacity of the pituitary gland to release growth hormone.

Use in combination with a drug delivery device for acute treatment of sickle cell vaso-occlusive crisis (pain crises)

To reduce the risk of chronic lung disease in premature neonates

Treatment of acute respiratory distress syndrome in adults.

Nitroprusside 2/21/2001

12/18/2007

Axitinib 5/4/2007

Novel Acting Thrombolytic (NAT) Treatment of peripheral arterial occlusion (PAO) 1/26/2001

Treatment of pancreatic cancer 8/17/2004

Treatment of renal cell carcinoma 7/28/2005

NZ-1002 4/11/2001

Obatoclax mesylate Treatment of chronic lymphocytic leukemia 10/8/2004

Obatoclax mesylate Treatment of myelodysplastic syndrome 11/6/2006

Obatoclax mesylate Treatment of myelofibrosis 12/1/2006

oblimersen Genasense Treatment of acute myelocytic leukemia 8/28/2001

oblimersen Genasense Treatment of multiple myeloma 8/28/2001

oblimersen Genasense Treatment of chronic lymphocytic leukemia 8/28/2001

oblimersen Genasense 7/31/2000

ofatumumab Treatment of chronic lymphocytic leukemia 3/10/2009

Treatment and prevention of cerebral vasospasm following subarachnoid hemorrhage.

N-malonyl-bis(N'-methyl-N'-thiobenzoylhydrazide)

Treatment of metastatic melanoma in combination with paclitaxel

N-Methyl-2-[3-[((E)-2-pyridin-2-yl-vinyl)-1H-indazol-6-ylsulfanyl]benzamide

Treatment of follicular, medullary and anaplastic thyroid carcinoma and metastatic or locally advanced papillary thyroid cancer.

Nucleic acid aptamer binding to tumor cell nucleolinNucleic acid aptamer binding to tumor cell nucleon

Enzyme replacement therapy in patients with all subtypes of Mucopolysaccharidosis I.

Enzyme replacement therapy in patients with all subtypes of Mucopolysaccharidosis I.

Treatment of advanced malignant melanoma (Stages II,III, IV).

oglufanide disodium Treatment of ovarian cancer 9/24/2001

OM 401 Drepanol Prophylactic treatment of sickle cell disease. 10/24/1991

omacetaine mepesuccinate Treatment of myelodysplastic syndromes 1/12/2009

Omacetaxine mepesuccinate Treatment of chronic myelogenous leukemia 3/10/2006

Prevention of organ graft rejection. 11/22/1995

Omacor Treatment of IgA nephropathy. 5/4/2000

Omegaven emulsion Omegaven 2/27/2008

omigapil Treatment of congenital muscular dystrophy. 6/24/2008

oncophage Treatment of glioma 4/14/2009

Oncorad Ov103 Treatment of ovarian cancer. 4/24/1990

oral unfractionated heparin Treatment of sickle cell disease 1/29/2004

Orgotein for injection 12/22/1994

Oxaliplatin Treatment of ovarian cancer. 10/6/1992

Oxalobacter formigenes Treatment of primary hyperoxaluria 3/29/2006

Oxandrolone Oxandrin 7/5/1990

Omega-3 (n-3) polyunsaturated fatty acid with all double bonds in the cis configuration

Omega-3 (n-3) polyunsaturated fatty acids

Treatment of parenteral nutrition-associated liver disease

Treatment of familial amyotrophic lateral sclerosis associated with a mutation of the gene (on chromosome 21q) for copper, zinc superoxide dismutase.

Treatment of short stature associated with Turner's syndrome.

Oxandrolone Treatment of constitutional delay of growth and puberty. 10/5/1990

Oxandrolone Oxandrin 4/22/1997

Oxandrolone Oxandrin 9/6/1991

Oxandrolone Hepandrin 3/18/1994

Oxymorphone Numorphan H.P. 3/19/1985

Oxypurinol 11/9/1998

For the treatment of cystic fibrosis 3/7/2001

Treatment of cystic fibrosis. 10/27/1998

paclitaxel Treatment of pancreatic cancer 5/1/2009

Paclitaxel Paxene Treatment of AIDS-related Kaposi's sarcoma. 4/15/1997

paclitaxel aqueous gel OncoGel (tm) Treatment of brain cancer. 12/23/2008

paclitaxel aqueous gel OncoGel(tm) Treatment of esophageal cancer 2/1/2008

paclitaxel, micellar Paclical Treatment of ovarian cancer

Pafuramidine maleate 8/31/2007

Treatment of patients with Duchenne's muscular dystrophy and Becker's muscular dystrophy.

Adjunctive therapy for AIDS patients suffering from HIV-wasting syndrome.

Treatment of moderate/severe acute alcoholic hepatitis in the presence of moderate protein calorie malnutrition.

For relief of severe intractable pain in narcotic-tolerant patients.

Treatment of hyperuricemia in patients intolerant to allopurinol.

p1-(uridine 5'-)-p4-(2'-deoxycytidine 5'-) tetraphosphate, tetrasodium salt

P1, P4-Di(uridine 5'-tetraphosphate), tetrasodium salt

Treatment of human African trypanosomiasis (sleeping sickness)

Pafuramidine maleate Treatment of malaria 5/14/2007

pafuramidine maleate Treatment of pneumocystis jiroveci pneumonia 11/17/2006

Palifosfamide Treatment of soft tissue sarcomas 5/5/2008

Panobinostat Faridak Treatment of cutaneous T-cell lymphoma 9/26/2007

Papain, trypsin, and chymotrypsin Wobe-Mugos Treatment of multiple myeloma. 12/21/1998

parathyroid hormone Treatment of hypoparathyroidism. 8/31/2007

1/18/2008

MEDI-491 5/7/1999

Patul-end 2/18/1997

Patupilone Treatment of ovarian cancer. 10/4/2005

PEG-glucocerebrosidase Lysodase 12/9/1992

Peginterferon alfa-2a PEGASYS Treatment of chronic myelogenous leukemia. 9/30/1999

Peginterferon alfa-2a PEGASYS Treatment of renal cell carcinoma. 7/13/1998

peginterferon alfa-2b PegIntron 4/9/2008

PEG-interleukin-2 2/1/1990

paromomycin sulfate/gentamicin sulfate

Treatment of non-complicated Old World cutaneous leishmaniasis

Parvovirus B19 (recombinant VP1 and VP2; S.frugiperda cells) vaccine

Prevention of transient aplastic crisis in patients with sickle cell anemia. Treatment of patulous eustachian tube.

For use as chronic enzyme replacement therapy in patients with Gaucher's disease who are deficient in glucocerebrosidase.

Treatment of malignant melanoma stages IIb through IV.

Treatment of primary immunodeficiencies associated with T-cell defects.

Pegylated arginine deiminase Melanocid Treatment of invasive malignant melanoma. 4/12/1999

Pegylated arginine deiminase Hepacid Treatment of hepatocellular carcinoma. 3/26/1999

MEGAGEN 10/20/1997

Peldesine Treatment of cutaneous T-cell lymphoma. 10/5/1993

Pentamidine isethionate Treatment of Pneumocystis carinii pneumonia. 10/29/1984

Pneumopent 10/5/1987

pentetate trisodium diethylenetriaminepen 4/12/2004

pentosan polysulfate sodium Treatment of sickle cell disease. 11/21/2008

Pentostatin Nipent 1/29/1991

Pentostatin Nipent Treatment of peripheral T-cell lymphomas. 11/24/1999

Pentostatin Nipent Treatment of cutaneous T-cell lymphoma. 3/27/1998

Peptide 144 TGF beta-1 inhibitor Treatment of systemic sclerosis 4/27/2006

Peptide 144 TGF beta-1-inhibitor Treatment of localized scleroderma 4/26/2006

Diagnosis of growth hormone deficiency 5/14/2007

Pegylated recombinant human megakaryocyte growth and development factor

For reducing the period of thrombocytopenia in patients undergoing hematopoietic stem cell transplantation.

Pentamidine isethionate (inhalation)

Prevention of Pneumocystis carinii pneumonia in patients at high risk of developing this disease.

Treatment of patients with known or suspected internal contamination with plutonium, americium, or curium.

Treatment of patients with chronic lymphocytic leukemia.

Peptidomimetic analog of hexarelin

Perflubron LiquiVent 4/26/2001

Perfosfamide Pergamid 12/4/1989

Pergolide Permax Treatment of Tourette's syndrome. 11/20/1997

Phenylacetate 3/6/1998

Phenylalanine ammonia-lyase Phenylase Treatment of hyperphenylalaninemia. 3/8/1995

Phenylbutyrate Treatment of acute promyelocytic leukemia. 1/19/2000

phenylephrine 2/14/2002

Phosphocysteamine Treatment of cystinosis. 9/12/1988

Treatment of Ewing's sarcoma 9/22/2008

phosphorothioate oligonucleotide Treatment of amyotrophic lateral sclerosis 11/9/2007

Picoplatin Treatment of small cell lung cancer 11/2/2005

Piracetam Nootropil Treatment of myoclonus. 10/2/1987

Piritrexim isethionate 6/13/1988

Treatment of cystic fibrosis 3/29/2005

Treatment of acute respiratory distress disease (ARDS) in adultsFor use in the ex-vivo treatment of autologous bone marrow and subsequent reinfusion in patients with acute myelogenous leukemia, also referred to as acute nonlymphocytic leukemia.

For use as an adjunct to surgery, radiation therapy and chemotherapy for the treatment of patients with primary or recurrent malignant glioma.

Treatment of ileal pouch anal anastomosis related fecal incontinence

phosphorothioate antisense olignucleotide against EWS-Fli-1

Treatment of infections caused by Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium-intracellulare.

Plasmid DNA vector expressing cystic fibrosis transmembrane gene

plasmin (human) Treatment of acute peripheral arterial occlusion (aPAO) 3/30/2009

Plevitrexed Plevitrexed Treatment of ovarian cancer 5/14/2007

Plevitrexed Plevitrexed Treatment of gastric (stomach) cancer 5/29/2007

Plitidepsin Aplidin Treatment of acute lymphoblastic leukemia 6/18/2004

Plitidepsin Aplidin Treatment of multiple myeloma 9/30/2004

Poloxamer 188 8/5/1997

Poloxamer 188 Flocor Treatment of sickle cell crisis. 6/27/1989

Poloxamer 188 Florcor Treatment of severe burns requiring hospitalization. 2/22/1990

Poloxamer 331 Protox Initial therapy of toxoplasmosis in patients with AIDS. 3/21/1991

Poly I: poly C12U Ampligen Treatment of renal cell carcinoma. 5/20/1991

Poly I: poly C12U Ampligen 12/9/1993

Poly I: poly C12U Ampligen Treatment of chronic fatigue syndrome. 12/9/1993

Poly I: poly C12U Ampligen Treatment of AIDS. 7/19/1988

Polyethylene glycol (PEG)-uricase 2/21/2001

Treatment of vasospasm in subarachnoid hemorrhage patients following surgical repair of a ruptured cerebral aneurysm.

Treatment of invasive metastatic melanoma (stage IIb, III, IV).

To control the clinical consequences of hyperuricemia in patients with severe gout in whom conventional therapy is contraindicated or has been ineffective.

6/6/2005

Zurase 9/14/1999

Zurase 12/21/1998

Poly-ICLC Hiltonol Treatment of primary brain tumors. 3/17/1997

polyinosinic-polycytidilic acid Poly-ICLC 3/3/2003

polyinosinic-polycytidilic acid Poly-ICLC As an adjuvant to smallpox vaccination 8/2/2002

Hiltonol Treatment for orthopox virus infections 11/19/2002

Polymeric oxygen Treatment of sickle cell anemia. 3/25/1992

polyphenon E Treatment of chronic lymphocytic leukemia 7/17/2008

Treatment of stage IIb to stage IV melanoma 6/9/2006

NeuroCell-PD 12/17/1996

NeuroCell-PD 12/17/1996

NeuroCell-HD Treatment of Huntington's disease. 12/10/1996

NeuroCell-HD Treatment of Huntington's disease. 12/10/1996

N-Graft 6/24/1997

Polyethylene glycol-modified uricase

Treatment of hyperuricemia in patients with gout refractory to conventional therapy or in whom conventional therapy is contraindicated

Polyethylene glycol-modified uricase

Prophylaxis of hyperuricemia in cancer patients prone to develop tumor lysis syndrome during chemotherapy.

Polyethylene glycol-modified uricase

Treatment of tumor lysis syndrome in cancer patients undergoing chemotherapy.

Treatment of flavivirus infections including those due to West Nile, Japanese encephalitis, dengue, St. Louis encephalitis, yellow fever, Murray valley, and Banzai viruses

polyinosinic-polycytidilic acid (Poly-ICLC)

Polyvalent, shed-antigen melanoma vaccinePorcine fetal neural dopaminergic cells and/or precursors aseptically prepared and coated with anti-MHC-1 Ab for intracerebral

Treatment of Hoehn and Yahr stage 4 and 5 Parkinson's disease.

Porcine fetal neural dopaminergic cells and/or precursors aseptically prepared for intracerebral implantation.

Treatment of Hoehn and Yahr stage 4 and 5 Parkinson's disease.Porcine fetal neural gabaergic

cells and/or precursors aseptically prepared and coated with anti-MHC-1 Ab for intracerebral Porcine fetal neural gabaergic cells and/or precursors aseptically prepared for intracerebral implantation for Huntington's Porcine Sertoli cells aseptically prepared for intracerebral co-implantation with fetal neural tissue

Treatment of Hoehn and Yahr stage four and five Parkinson's disease.

Porfimer sodium Photofrin Treatment of cholangiocarcinoma 11/18/2004

Porfimer sodium Photofrin 11/15/1989

Porfiromycin Promycin Treatment of cervical cancer. 3/13/1997

Porfiromycin Promycin Treatment of head and neck cancer. 9/19/1995

Posaconazole Posoril Treatment of zygomycosis 7/16/2004

Potassium citrate and citric acid 2/14/1986

potassium sodium aluminosilicate For treatment of poisoning by or exposure to cesium. 1/8/2007

PR1 Vaccine 9/3/2004

PR1 Vaccine Treatment of acute myelogenous leukemia 9/3/2004

PR1 Vaccine Treatment of chronic myelogenous leukemia. 9/3/2004

Pr-122 (redox-phenytoin) 7/5/1990

PR-225 (redox-acyclovir) 5/29/1990

PR-239 (redox penicillin G) Treatment of AIDS associated neurosyphilis. 5/23/1990

7/20/1990

For the photodynamic therapy of patients with transitional cell carcinoma in situ of the urinary bladder.

For the dissolution and control of uric acid and cysteine calculi in the urinary tract.

Treatment of myelodysplastic syndromes requiring therapy

For the emergency rescue treatment of status epilepticus, grand mal type.

Treatment of herpes simplex encephalitis in individuals afflicted with AIDS.

Pr-320 (molecusol-carbamazepine)

For the emergency rescue treatment of status epilepticus, grand mal type.

pralatrexate Treatment of diffuse large B-cell lymphoma 10/20/2008

pralatrexate Treatment of follicular lymphoma 10/20/2008

pralatrexate Treatment of T-cell lymphoma 7/20/2006

pramipexole Mirapex Treatment of Tourette's syndrome in pediatric patients 1/31/2008

Pramiracetam Sulfate 11/4/1991

Praziquantel Treatment of neurocysticercosis. 4/18/1988

Prednimustine Sterecyt Treatment of malignant non-Hodgkin's lymphomas. 6/17/1985

Primaquine phosphate 7/23/1993

Procarbazine HCl Matulane Treatment of malignant glioma 8/8/2006

Progesterone 12/22/1994

Brolene Treatment of acanthamoeba keratitis. 3/10/1988

propanolol 9/5/2008

Circulase 6/12/1998

Prostaglandin E1 in lipid emulsion Lipo-PGE1 9/10/1996

For the management of cognitive dysfunction and enhancement of antidepressant activity associated with electroconvulsive therapy.

For use in combination with clindamycin hydrochloride in the treatment of Pneumocystis carinii pneumonia associated with AIDS.

Establishment and maintenance of pregnancy in women undergoing in vitro fertilization or embryo transfer procedures.

Propamidine isethionate 0.1% ophthalmic solution

Treatment of proliferating infantile hemangiomas requiring systemic therapy

Prostaglandin E1 enol ester (AS-013)

Treatment of Fontaine Stage IV chronic critical limb ischemia.

Treatment of ischemic ulceration of the lower limbs due to peripheral arterial disease.

Protaxel Treatment of ovarian cancer 5/21/2003

Protein C concentrate Protein C Concentrat 4/22/1993

Protein C concentrate Protein C Concentrat 6/19/1992

Protirelin 8/24/1993

Protirelin injection Treatment of amyothrophic lateral sclerosis. 1/10/1985

Pulmonary surfactant replacement 12/5/1988

purified bovine type collagen Treatment of idiopathic pulmonary fibrosis 4/27/2009

ImmuDyn 9/22/1997

Purified type II collagen Colloral Treatment of juvenile rheumatoid arthritis. 2/9/1995

Pyruvate Treatment of interstitial lung disease. 2/21/2001

Quinacrine hydrochloride 10/17/1984

quinine sulfate Treatment of malaria excluding Plasmodium faliparum 12/2/2008

R-(-)-gossypol Treatment of chronic lymphocytic leukemia. 10/24/2006

11/28/2008

rAAV2-CB-hRPE65 Treatment of type II Leber's Congential Amaurosis 2/11/2005

For use in the prevention and treatment of purpura fulminans in meningococcemia.For replacement therapy in patients with congenital or acquired protein C deficiency for the prevention and treatment of warfarin-induced skin necrosis during oral anticoagulation.

Prevention of infant respiratory distress syndrome associated with prematurity.

Prevention and treatment of infant respiratory distress syndrome.

Purified extract of Pseudomonas aeruginosa

Treatment of immune thrombocytopenia purpura where it is required to increase platelet counts.

For prevention of recurrence of pneumothorax in patients at high risk of recurrence.

R-4-amino-3-(4-chlorophenyl)butanoic acid

Treatment of the behavorial abnormalities associated with fragile X syndrome.

Thymoglobulin 9/26/2006

ranprinase Onconase Treatment of malignant mesothelioma 1/25/2007

Rapamycin Treatment of tuberous sclerosis complex 3/20/2007

Rapamycin (mTOR) inhibitor Treatment of bone sarcoma 8/9/2005

raxibacumab Abthrax Treatment of anthrax 11/12/2003

rAAV-AAT Treatment of alpha1-antitrypsin deficiency 1/27/2003

11/15/2007

Treatment of hairy cell leukemia 11/15/2007

Treatment of chronic lymphocytic leukemia 8/12/2005

Treatment of multiple myeloma 1/25/2006

Neuprex Treatment of severe meningococcal disease. 6/22/1998

Anthim Treatment of exposure to B. anthracis spores 6/9/2006

Novoseven Treatment of diffuse alveolar hemorrhage 4/26/2006

Cethrin Treatment of acute spinal cord injury 11/18/2005

Rabbit anti-human thymocyte globulin (rATG)

Induction treatment to prevent rejection and to minimize maintenance immunosupression in pediatric liver transplant recipients

recombinant adeno-associated virus alpha 1-antitrypsin vector

Recombinant anti-CD22 immunotoxin

Treatment of CD22-positive chronic lymphocytic leukemia

Recombinant anti-CD22 immunotoxin

Recombinant anti-CD40 monoclonal antibody

Recombinant anti-CD-40 monoclonal antibodyRecombinant bactericidal/permeability-increasing protein

recombinant chimeric monoclonal antibody to anthraxRecombinant coagulation factor VIIa

Recombinant deriative of C3 transferase

7/29/2008

7/29/2008

8/18/2005

Valortim Treatment of anthrax infection 2/16/2006

Proxinium 1/28/2005

Treatment of short bowel syndrome. 6/29/2000

Prevention of bronchopulmonary dysplasia 4/28/2005

Treatment of cystic fibrosis 11/20/2001

Treatment of cystic fibrosis. 3/6/1998

8/28/2001

Treatment of myasthenia gravis 2/22/2001

Treatment of alpha-mannosidosis 2/2/2006

2/16/2005

4/6/2000

Treatment of metachromatic leukodystrophy (MLD). 4/11/2008

Recombinant disintegrin and metalloprotease with thrombospondin type 1 motifs

Treatment of thrombotic thrombocytopenic purpura including its congential, acquired idiopathic, and secondary forms.

Recombinant disintegrin and metalloprotease with thrombospondin type 1 motifs

Prevention of thrombotic thrombocytopenic purpura including its congential, acquired idiopathic and secondary forms.

Recombinant Epstein-Barr virus gp350 glycoprotein vaccine

Prevention of post-transplantation lymphoproliferative disorders in pediatric recipients of solid-organ transplantation

Recombinant fully human monoclonal antibody to anthrax protective antigen recombinant fusion protein with a truncated form of the cytotoxic protein Pseudomonas exotoxin

Treatment of Ep-CAM-positive squamous cell carcinoma of the head and neck

Recombinant glycine2-human glucagon-like peptide-2Recombinant human alpha 1-antitrypsin

recombinant human alpha 1-antitrypsin (rAAT)recombinant human alpha-1 antitrypsin

recombinant human alpha-1 antitrypsin (rAAT)

To delay progression of chronic obstructive pulmonary disease resulting from AAT deficiency-mediated emphysema and bronchiectasis

Recombinant Human Alpha-Fetoprotein (rhAFP)

Recombinant human alpha-mannosidaseRecombinant human anti-GDF-8 (growth and differentiation factor-8) antibody

Treatment of Duchenne and Becker muscular dystrophies

Recombinant human antithrombin III

Treatment of antithrombin III dependent heparin resistance requiring anticoagulation.

recombinant human arylsulphatase A

Recombinant human C1 inhibitor Treatment of capillary leakage syndrome 6/9/2006

Recombinant human C1 inhibitor 6/9/2006

2/23/1999

2/23/1999

Treatment of AIDS resulting from infection with HIV-1. 8/30/1990

7/13/1998

10/30/2008

Treatment of neuroendocrine tumors 8/13/2001

Treatment of metastatic melanoma 2/21/2002

Recombinant human fibrinogen Treatment of bleeding in patients deficient in fibrinogen 10/4/2007

Treatment of radiation induced oral mucositis 1/29/2004

Recombinant human gelsolin 3/6/1995

Recombinant human gelsolin 1/12/1994

Prevention of implantation failure 7/24/2006

TBD 9/20/2000

Prevention and/or treatment of delayed graft function after solid organ transplantation

Recombinant human C1-esterase inhibitor

Treatment of (acute attacks of) angioedema caused by hereditary or acquired C1-esterase inhibitor deficiency.

Recombinant human C1-esterase inhibitor

Prophylactic treatment of angioedema caused by hereditary or acquired C1-esterase inhibitor deficiency.

Recombinant human CD4 immunoglobulin G

Recombinant human Clara Cell 10kDa protein

Prevention of neonatal bronchopulmonary dysplasia in premature neonates with respiratory distress syndrome.

recombinant human coagulation factor IX fusion protein

For the control and prevention of hemorrhagic episodes in patients with hemophilia B (congential factor IX deficiency or Christmas disease).

Recombinant human endostatin protein

recombinant human endostatin protein

recombinant human fibroblast growth factor-20

Treatment of acute and chronic respiratory symptoms of bronchiectasis.

Treatment of the respiratory symptoms of cystic fibrosis.

Recombinant human granulocyte colony stimulating factor

Recombinant human highly phosphorylated acid alpha-glucosidase

For enzyme replacement therapy in patients with all subtypes of glycogen storage disease type II (GSDII, Pompe Disease)

Oncohist (r) Treatment of acute myeloid leukemia 10/20/2008

IGF-1 Treatment of growth hormone receptor deficiency. 6/7/1995

IGF-1 6/7/1995

PV802 2/16/2000

Treatment of post-poliomyelitis syndrome. 10/13/1995

Treatment of major burns that require hospitalization. 6/15/1999

Treatment of renal cell carcinoma. 10/20/1997

10/4/2005

12/20/1999

Cholestrase 7/14/2005

Treatment of peripheral arterial occlusion 1/23/2006

MUBODINA 2/4/2009

2/4/2009

Mycograb Treatment of invasive candidiasis 9/16/2002

recombinant human histone H1.3; recombinant human N-bis-met-histone H1.3

Recombinant human insulin-like growth factor 1

Recombinant human insulin-like growth factor 1

Treatment of antibody-mediated growth hormone resistance in patients with isolated growth hormone deficiency Ia.

Recombinant human insulin-like growth factor-I

Treatment of short-bowel syndrome as a result of resection of the small bowel or as a result of congenital dysfunction of the intestines.

Recombinant human insulin-like growth factor-IRecombinant human insulin-like growth factor-I/insulin-like growth factor binding protein-3

Recombinant human interleukin-12

Recombinant Human Interleukin-21 (rIL-21)

Treatment of stage II (T4), III or IV malignant melanoma.

Recombinant human keratinocyte growth factor

Reducing the incidence and severity of radiation-induced xerostomia.

Recombinant human lysosomal acid lipase or cholesteryl ester hydrolase

Treatment of lipase deficiencies, including Wolman Disease and cholesteryl ester storage disease

Recombinant human microplasminrecombinant human minibody against complement component C5

Treatment of primary membranoproliferative glomerulonephritis

recombinant human minibody against complement component C5 fused with RGD-motif

Prevention of ischemmia/reperfusion injury associated with solid organ transplantation.

recombinant human monoclonal antibody to hsp90

Treatment of HIV-associated sensory neuropathy. 4/16/1999

Treatment of cystic fibrosis 12/9/2003

Treatment of osteonecrosis of the jaws 2/1/2007

Porphozyme Treatment of acute intermittent porphyria attacks 9/9/2002

7/11/2002

recombinant human proinsulin Treatment of retinitis pigmentosa 12/10/2008

Recombinant human relaxin Treatment of progressive systemic sclerosis. 11/3/1995

Treatment of retinitis pigmentosa 1/7/2008

9/29/1997

4/3/2009

6/18/2008

Prevention of rejection of solid organ transplants. 3/22/1999

3/22/1999

10/14/1998

Recombinant human nerve growth factorrecombinant human neutrophil inhibitor (hNE)

Recombinant human platelet derived growth factor BB

recombinant human porphobilinogen deaminaserecombinant human porphobilinogen deaminase, erythropoetic form

Treatment of acute intermittent porphyria preventing attacks

recombinant human rod-derived cone viability factorRecombinant human thrombopoietin

For use in accelerating platelet recovery in patients undergoing hematopoietic stem cell transplantation.

recombinant human type I pancreatic elastase

Prevention of arteriovenous fistula maturation and arteriovenous graft failure in patients with end stage renal disease who are receiving hemodialysis or preparing for hemodialysis

recombinant human type VII collagen

Treatment of hereditary dystrophic epidermolysis bullosa (DEB)

Recombinant humanized MAb 5c8

Recombinant humanized MAb 5c8

Prevention of rejection of pancreatic islet cell transplants.

Recombinant humanized MAb 5c8

Prevention and treatment of Factor VIII/Factor IX inhibitors in patients with hemophilia A or B.

Treatment of immune thrombocytopenic purpura. 2/3/1998

Treatment of systemic lupus erythematosus. 2/18/1998

Treatment of amyotrophic lateral sclerosis. 11/28/1994

recombinant ovine interferon tau Tauferon Treatment of pediatric multiple sclerosis 1/25/2005

3/16/2004

3/29/2006

7/26/2007

11/15/1993

Treatment of cystic fibrosis. 3/29/1991

Treatment of congenital alpha-1 antitrypsin deficiency. 3/29/1991

Recombinant soluble human CD4 Receptin Treatment of acquired immunodeficiency syndrome. 11/20/1989

Treatment of AIDS in patients infected with HIV virus. 3/23/1989

5/2/2003

Treatment of cystic fibrosis 6/24/2005

Recombinant humanized monclonal antibody 5c8

Recombinant humanized monoclonal antibody 5c8

Recombinant methionyl brain-derived neurotrophic factor

Recombinant Porcine Factor VIII, B-domain Deleted

Treatment and prevention of episodic bleeding in patients with inhibitor antibodies to human coagulation factor VIII

Recombinant P-Selectin glycoprotein ligand

Prevention of delayed graft function in renal transplant patientsRecombinant P-selectin

glycoprotein ligand-immunoglobulin Ig

Prevention of ischemia reperfusion injury in all solid organ transplants

Recombinant retroviral vector - glucocerebrosidase

For use as enzyme replacement therapy for patients with types I, II, or III Gaucher disease.

Recombinant secretory leucocyte protease inhibitor

Recombinant secretory leucocyte protease inhibitor

Recombinant soluble human CD4 (rCD4)

Recombinant T-cell receptor ligand

Treatment of multiple sclerosis patients who are both HLA-DR2 positive and autoreactive to myelin oligodendrocyte glycoprotein residues 35-55

Recombinant truncated SPINT2 protease inhibitor

Recombinant urate oxidase Prophylaxis of chemotherapy-induced hyperuricemia. 10/11/2000

Reduced L-glutathione Cachexon Treatment of AIDS-associated cachexia. 2/14/1994

Remacemide Ecovia Treatment of Huntington's disease. 3/6/2000

Reparixin 1/27/2003

H.P. Acthar Gel Treatment of infantile spasms 5/21/2003

resiniferatoxin Treatment of intractable pain at end-stage disease 5/13/2003

reslizumab Treatment of children with eosinophilic esophagitis 12/19/2007

Hypermune RSV 9/27/1990

retaspimycin Treatment for gastrointestinal stromal tumor 8/31/2007

retaspimycin hydrochloride Treatment of melanoma stages IIb through IV. 6/24/2008

R-etodolac Treatment of chronic lymphocytic leukemia 12/9/2002

4/29/2002

Treatment of Gaucher disease. 5/6/1997

Reviparin sodium Clivarine 6/18/2001

Reviparin sodium Clivarine 6/18/2001

Prevention of delayed graft function in solid organ transplant

repository corticotropin or adrenocorticotropic hormone

Respiratory Syncytial Virus Immune Globulin (human)

Treatment of respiratory syncytial virus lower respiratory tract infections in hospitalized infants and young children.

retroviral gamma-c cDNA containing vector

Treatment of X linked severe combined immune deficiency disease

Retroviral vector, R-GC and GC gene 1750

Treatment of deep vein thrombosis which may lead to pulmonary embolism in pediatric patients

Long-term treatment of acute deep vein trombosis with or without pulmonary embolism in pregnant patients

RGG0853, E1A lipid complex Treatment of ovarian cancer. 9/15/1995

rhIGF-I/rhIGFBP-3 SomatoKine 12/9/2003

rh-microplasmin Adjunct to surgery in cases of pediatric vitrectomy 3/16/2004

Ribavirin Virazole Treatment of hemorrhagic fever with renal syndrome. 4/12/1991

1/24/1991

Treatment of B-cell leukemia and B-cell lymphoma. 11/17/1988

8/3/1989

2/1/1990

Treatment of small cell lung cancer 1/25/1991

9/6/1994

Rifabutin 12/18/1989

Rifalazil Treatment of pulmonary tuberculosis. 4/13/1999

Rifapentine Priftin 3/12/1996

Rifapentine Priftin 6/9/1995

Rifaximin Normix Treatment of hepatic encephalopathy 2/10/1998

Treatment of extreme insulin resistance syndromes (type A, Rabson-Mendenhall syndrome, Leprechaunism, Type B syndrome)

Ricin (blocked) conjugated murine mca (anti-b4)

For the ex-vivo purging of leukemic cells from the bone marrow of non-T cell acute lymphocytic leukemia patients who are in complete remission.

Ricin (blocked) conjugated murine MCA (anti-B4)

Ricin (blocked) conjugated murine MCA (anti-my9)

Treatment of myeloid leukemia, including AML, and blast crisis of CML.

Ricin (blocked) conjugated murine MCA (anti-my9)

For use in the ex-vivo treatment of autologous bone marrow and subsequent reinfusion in patients with acute myelogenous leukemia.

Ricin (blocked) conjugated murine MCA (n901)

Ricin (blocked) conjugated murine monoclonal antibody (CD6)

Treatment of cutaneous T-cell lymphomas, acute T-cell leukemia-lymphoma, and related mature T-cell malignancies.

Treatment of disseminated Mycobacterium avium complex disease.

Prophylactic treatment of Mycobacterium avium complex in patients with AIDS and a CD4+ count less than or equal to 75/mm3.

Treatment of Mycobacterium avium complex in patients with AIDS.

RII retinamide Treatment of myelodysplastic syndromes. 5/6/1993

Riluzole Rilutek Treatment of Huntington's disease. 10/15/1996

risedronate sodium Actonel Treatment of patients with osteogenesis imperfecta. 12/18/2006

rituximab Rituxan 2/14/2006

rituximab Rituxan Treatment of immune thrombocytopenic purpura 3/12/2002

rituximab Rituxan Treatment of chronic lymphocytic leukemia 1/29/2004

Treatment of Duchenne Muscular Dystrophy. 10/23/2007

rofecoxib Vioxx Treatment of juvenile rheumatoid arthritis 3/16/2004

romidepsin Treatment of non-Hodgkin T-cell lymphomas 9/30/2004

Roquinimex Linomide 7/1/1993

Rose Bengal Disodium Treatment of metastatic melanoma 12/20/2006

rSP-C lung surfactant Venticute Treatment of adult respiratory distress syndrome. 4/3/2000

rSP-C surfactant Venticute 9/18/2006

rubitecan 7/17/2002

Treatment of multiple myeloma 3/14/2002

Treatment of patients with anti-neutrophil cytoplasmic antibody-associated vasculitis (Wegener's Granulomatosis, Microscopic Polyangiitis, and Churg-Strauss Syndrome)

RNA, ((2',3'-dideoxy-2',3'-imino-2',3'-seco)[dimethylamino)phosphinylideneoxy](2'a-5') (CTC CAA CAT CAA

To prolong time to relapse in leukemia patients who have undergone autologous bone marrow transplantation.

For use in patients with pneumonia or aspiration of gastric contents leading to intubation, mechanical ventilation, and severe oxygen impairmentTreatment of pediatric patients infected with human immunodeficiency virus and acquired immunodeficiency syndrome

S(-)-3-[3-amino-phthalimido]-glutaramide

S-adenosylmethionine Treatment of AIDS-myelopathy. 4/30/1998

salirasib Treatment of panreatic cancer. 12/18/2006

sarsasapogenin Treatment of amyotrophic lateral sclerosis (ALS) 6/18/2004

SB-408075 For pancreatic cancer 12/7/2000

SC-1 monoclonal antibody 11/12/2003

SCH 58500 Treatment of primary ovarian cancer. 4/12/1999

SDF-1 (108) Lysine Dlmer Treatment of osteogenic sarcoma 7/7/2005

Secalciferol Osteo-D Treatment of familial hypophosphatemic rickets. 7/26/1993

Treatment of bronchopulmonary dysplasia. 6/30/1992

Seneca Valley virus Treatment of neuroendocrine tumors Treatment of neuroendocrine tumors 8/22/2008

Sermorelin acetate Geref 2/13/1990

Sermorelin acetate Geref Treatment of AIDS-associated catabolism/weight loss. 12/5/1991

Imuvert Treatment of primary brain malignancies. 9/7/1988

SGN-30 (anti-CD30 antibody) Treatment of CD30 positive T-cell lymphomas 2/18/2004

SGN-30 (anti-CD30 mAb) Treatment of Hodgkin's disease 7/18/2003

SGN-35 (cAC10-vcMMAE(4)) Treatment of anaplastic large cell lymphoma 10/23/2008

Treatment of patients with CD55 (sc-1) positive gastric tumors

Secretory leukocyte protease inhibitor

Adjunct to gonadotropin therapy in the induction of ovulation in women with anovulatory or oligo-ovulatory infertility who fail to ovulate in response to adequate treatment with clomiphene citrate alone and

Serratia marcescens extract (polyribosomes)

SGN-40 (anti-CD40 antibody) Treatment of multiple myeloma. 8/13/2004

Short chain fatty acid enema Colomed Treatment of chronic radiation proctitis. 8/19/1997

Short chain fatty acid solution Colomed 5/29/1990

Flammacerium Prevention of mortality in severely burned patients. 11/17/1999

siplizumab Treatment of T-cell lymphomas 7/15/2003

Sitaxsentan Sodium 11/2/2004

SK&F 110679 5/23/1990

sodium 2, 2 dimethylbutyrate Treatment of sickle cell disease. 7/25/2008

Treatment of ovarian cancer 4/3/2009

Sodium aluminosilicate Treatment of chronic hepatic encephalopathy 3/4/2005

Apatone 7/31/2007

Sodium dichloroacetate 6/11/1990

Sodium dichloroacetate Treatment of congenital lactic acidosis. 6/11/1990

Sodium dichloroacetate Treatment of congenital lactic acidosis. 12/31/1997

Treatment of the active phase of ulcerative colitis with involvement restricted to the left side of the colon.

Silver sulfadiazine and cerium nitrate

For the treatment of pulmonary arterial hypertension in the absence of chronic obstructive pulmonary disease or congestive heart failure.

For the long term treatment of children who have growth failure due to a lack of adequate endogenous growth hormone secretion.

sodium 4-{ [9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido [5,4-d] [2] benzazepin-2-yl]-2-methoxybenzoate

Sodium ascorbate and menadione sodium bisulfite

Treatment of metastatic or locally advanced inoperable transitional cell carcinoma of the urothelium (stage III and IV bladder cancer)

Treatment of homozygous familial hypercholesterolemia.

Sodium dichloroacetate 11/10/1994

sodium dichloroacetate 7/3/2003

Sodium dichloroacetate Ceresine Treatment of severe head injury. 6/14/1999

Borocell 4/15/1992

12/18/1984

Sodium nitrite 4/2/2007

Sodium nitrite Treatment of cyanide poisoning 4/18/2007

Sodium nitrite 1/17/2007

sodium nitrite Treatment of pulmonary arterial hypertension 7/8/2008

Cyanide Antidote Kit Treatment of known or suspected cyanide poisoning 4/9/2008

Sodium nitrite/sodium thiosulfate Cyanide Antidote Pac Treatment of cyanide poisoning 3/23/2007

Ammonul Treatment of grade III and IV hepatic encephalopathy 6/3/2005

Sodium phenylbutyrate Treatment of spinal muscular atrophy 3/20/2007

Sodium phenylbutyrate Buphenyl Treatment of spinal muscular atrophy 1/25/2007

Treatment of lactic acidosis in patients with severe malaria.

Use as an antidote in the management of systemic monochloroacetic acid poisoning

Sodium Monomercaptoundecahydro-closo-dodecaborate

For use in boron neutron capture therapy (BNCT) in the treatment of glioblastoma multiforme.

Sodium monomercaptoundecahydro-closo-dodecaborate

For use in conjunction with a thermal or epithermal neutron beam in boron nuclear capture therapy of glioblastoma multiforme.

Treatment of vaso-occlusive crisis associated with sickle cell disease

Prevention of vasospasm associated with subarachnoid hemorrhage

Sodium nitrite and sodium thiosulfate

Sodium phenylacetate/sodium benzoate 10%/10% Injection

Sodium phenylbutyrate 4/24/1998

sodium phenylbutyrate 7/2/1992

Sodium pyruvate Treatment of cystic fibrosis 3/31/2003

Sodium stibogluconate Treatment of cutaneous leishmaniasis 6/16/2006

Sodium thiosulfate 3/17/2004

Treatment of cyanide poisoning 12/18/2006

Cyanide Antidote Pac Treatment of cyanide poisoning 6/16/2006

Solasonine and solamargine Coramsine Treatment of renal cell carcinoma 11/2/2005

Solasonine and solamargine Coramsine 2/6/2006

3/6/2000

11/21/1994

UNIPLAS Treatment of thrombotic thrombocytopenic purpura 12/12/2005

Somatostatin Zecnil 6/20/1988

Somatostatin Treatment of bleeding esophageal varices. 12/22/1994

Somatrem for injection Protropin 12/9/1985

For use as an adjuct to surgery, radiation therapy and chemotherapy for the treatment of patients with primary or recurrent malignant glioma. Treatment for sickling disorders, which include S-S hemoglobinopathy, S-C hemoglobinopathy, and S-thalassemia hemoglobinopathy.

Prevention of platinum-induced ototoxicity in pediatric patients

Sodium thiosulfate and sodium nitrite

Sodium thiosulfate, sodium nitrite, amyl nitrite

Treaatment of high risk stage II, stage III and stage IV melanoma

Soluble complement receptor type 1

Prevention of post-cardiopulmonary bypass syndrome in children undergoing cardiopulmonary bypass.

Soluble recombinant human complement receptor type 1

Prevention or reduction of adult respiratory distress syndrome.

Solvent/detergent treated non-blood group specific human coagulation active plasma

Adjunct to the non-operative management of secreting cutaneous fistulas of the stomach, duodenum, small intestine (jejunum and ileum), or pancreas.

Treatment of short stature associated with Turner's syndrome.

Somatropin Humatrope 12/15/2005

Somatropin Norditropin 11/5/1987

Somatropin Norditropin 9/1/1987

Somatropin Biotropin Treatment of cachexia associated with AIDS. 2/12/1993

Somatropin Serostim 3/16/2004

Somatropin (rDNA) Saizen 5/3/1989

Somatropin (r-DNA) for injection Serostim 3/26/1996

Sorafenib Nexavar Treatment of stage IIB through stage IV melanoma 9/29/2006

Sorivudine BRAVAVIR 11/9/1995

Sotalol HCl Betapace 9/23/1988

spherical carbon adsorbent Treatment of chronic pouchitis 12/19/2007

Spiramycin Rovamycine 10/17/1984

squalamine lactate Treatment of ovarian cancer 5/11/2001

SS1(dsFv)-PE38 Treatment of epithelial ovarian cancer 2/11/2002

SS1(dsFv)-PE38 Treatment of malignant mesothelioma 2/11/2002

Treatment of short stature in pediatric patients with short stature homeobox-containing gene (SHOX) deficiency

Treatment of short stature associated with Turner's syndrome.Adjunct for the induction of ovulation in women with infertility due to hypogonadotropic hypogonadism or bilateral tubal occlusion or unexplained infertility, who are undergoing in vivo or in vitro fertilization

Treatment of patients with HIV-associated adipose redistribution syndrome

For the enhancement of nitrogen retention in hospitalized patients suffering from severe burns.

Treatment of children with AIDS-associated failure-to-thrive including AIDS-associated wasting.

Treatment of herpes zoster (shingles) in immunocompromised patients.

Prevention of life threatening ventricular tachyarrhythmias.

For symptomatic relief and parasitic cure of chronic cryptosporidiosis in patients with immunodeficiency.

Treatment of ovarian cancer refractory or resistant to standard chemotherapy

8/12/1987

8/12/1987

Altastaph 1/29/2004

StemEx 3/4/2005

Sterile talc Steritalc Treatment of malignant pleural effusion. 12/8/1997

Sterile talc Steritalc Treatment of pneumothorax. 12/8/1997

stiripentol diacomit(r) Treatment of Dravet syndrome 10/30/2008

SU101 Treatment of ovarian cancer. 3/12/1996

SU101 Treatment of malignant glioma. 5/25/1995

Succimer Chemet Treatment of mercury intoxication. 3/22/1991

Succimer Chemet 11/5/1990

Sucralfate 7/15/1993

Sucralfate suspension 3/12/1990

ST1-RTA immunotoxin (SR 44163)

Treatment of patients with B-chronic lymphocytic leukemia.

ST1-RTA immunotoxin (SR 44163)

Prevention of acute graft versus host disease in allogenic bone marrow transplantation.

Staphylococcus aureus Immune Globulin (Human)

Prophylaxis against Staphylococcus aureus infections in low birth weight neonates

Stem and progenitor cells derived from ex vivo expanded allogeneic umbilical cord blood

For use as hematopoietic support in patients with relasped or refractory hematologic malignancies who are receiving high-dose therapy

Prevention of cystine kidney stone formation in patients with homozygous cystinuria who are prone to stone development.

Treatment of oral mucositis and stomatitis following radiation therapy for head and neck cancer.

Treatment of oral complications of chemotherapy in bone marrow transplant patients.

Sucralfate suspension 3/4/1991

sulfamidase For treatment of Sanfilippo Syndrome. 5/22/2008

Sulfapyridine Treatment of dermatitis herpetiformis. 9/10/1990

Superoxide dismutase (human) 3/6/1985

Oxsodrol Prevention of reperfusion injury to donor organ tissue. 5/17/1988

Suramin Metaret Treatment of hormone-refractory prostate cancer. 5/6/1997

Human Surf 3/25/1987

Synsorb Pk Treatment of verocytotoxogenic E. coli infections. 7/17/1995

Treatment of hypoparathyroidism 1/26/2001

Synthetic human secretin 9/18/2006

Synthetic human secretin 6/16/1999

Synthetic human secretin 3/7/2000

Synthetic human secretin 6/16/1999

Synthetic human secretin 6/16/1999

Treatment of oral ulcerations and dysphagia in patients with epidermolysis bullosa.

For protection of donor organ tissue from damage or injury mediated by oxygen-derived free radicals that are generated during the necessary periods of ischemia (hypoxia, anoxia), and especially reperfusion,

Superoxide dismutase (recombinant human)

Surfactant (human) (amniotic fluid derived)

Prevention and treatment of neonatal respiratory distress syndrome.

Synthetic Human Parathyroid Hormone 1-34

For use in conjunction with diagnostic procedures (excluding ERCP) for pancreatic disorders to increase pancreatic fluid secretion

For use in the diagnosis of gastrinoma associated with Zollinger-Ellison syndrome.

For use in conjunction with diagnostic procedures for pancreatic disorders to increase pancreatic fluid secretion.

For use in obtaining desquamated pancreatic cells for cytopathologic examination in pancreatic carcinoma.

For use in the evaluation of exocrine pancreas function.

Synthetic porcine secretin 6/18/1999

6/27/1989

Tacrolimus Prograf Prophylaxis of graft-versus-host-disease. 4/6/1998

Tadalafil Cialis Treatment of pulmonary arterial hypertension 12/18/2006

TAK-603 Treatment of Crohn's disease. 5/13/1998

Talactoferrin alfa Treatment of non-small cell lung cancer 8/8/2007

talactoferrin alfa Treatment of renal cell carcinoma 9/29/2006

talactoferrin alfa For the treatment of graft versus host disease 8/20/2003

talactoferrin alfa For the prevention of graft-versus-host disease 8/20/2003

talampanel Treatment of glioma 2/17/2009

talampanel Treatment of amyotrophic lateral sclerosis 3/24/2008

Tamibarotene Treatment of acute promyelocytic leukemia (APL). 10/11/2007

Tanespimycin Treatment of multiple myeloma 9/9/2004

Treatment of chronic granulomatous disease 11/1/2001

For use in obtaining desquamated pancreatic cells for cytopathologic examination in pancreatic carcinoma.

T4 endonuclease V, liposome encapsulated

To prevent cutaneous neoplasms and other skin abnormalities in xeroderma pigmentosum.

T-cell depleted stem cell enriched cellular product from peripheal blood stem cells

TD-K6a.513a.12 ReveKer Treatment of pachyonychia congenita 6/15/2006

For the identification of ovarian carcinomas. 2/16/2000

Oncotrac Melanoma I 6/2/1987

LymphoScan 4/7/1992

Immuraid, hCG-Tc-9 8/7/1989

AFP-Scan 8/1/1989

Immuraid, AFP-Scan 8/1/1989

Technetium Tc99m rh-Annexin V Apomate 11/3/2000

Tegafur/gimeracil/oteracil Treatment of gastric cancer 7/20/2006

temocillin sodium Negaban 4/21/2004

Temoporfin Foscan 10/28/1999

Temozolomide Temodal Treatment of newly diagnosed high grade glioma 10/18/2004

Temozolomide Temodal Treatment of advanced metastatic melanoma. 10/14/1998

tenofovir disoproxil fumarate Viread(r) Treatment of pediatric HIV infection. 3/17/2009

terguride Treatment of pulmonary arterial hypertension 5/1/2008

Technetium Tc 99m pterotetramideTechnetium Tc99m anti-melanoma murine monoclonal antibody

For use in detecting, by imaging, metastases of malignant melanoma.

Technetium Tc99m murine monoclonal antibody (IgG2a) to B cell

Diagnostic imaging in the evaluation of the extent of disease in patients with histologically confirmed diagnosis of non-Hodgkin's B-cell lymphoma, acute B-cell lymphoblastic leukemia (in children and adults),

Technetium Tc99m murine monoclonal antibody to hCG

Detection of hCG producing tumors such as germ cell and trophoblastic cell tumors.Technetium Tc99m murine

monoclonal antibody to human AFP

Detection of alpha-fetoprotein producing germ cell tumors.

Technetium Tc99m murine monoclonal antibody to human alpha-fetoprotein

Detection of hepatocellular carcinoma and hepatoblastoma.

Diagnosis or assessment of rejection status in heart, heart-lung, single lung, or bilateral lung transplants.

Treatment of pulmonary infections caused by Burkholderia cepaciaPalliative treatment of recurrent, refractory or second primary squamous cell carcinomas of the head and neck in patients considered to be incurable with surgery or radiotherapy.

Teriparatide Parathar Treatment of idiopathic osteoporosis. 10/28/1999

Terlipressin Glypressin Treatment of bleeding esophageal varices. 3/6/1986

Terlipressin (INN) Treatment of Hepatorenal Syndrome 10/29/2004

tesetaxel 11/21/2008

tesetaxel Treatment of gastric cancer 12/22/2008

Testosterone TheraDerm Testoster 9/22/1997

Treatment of vulvar dystrophies. 7/31/1991

Testosterone sublingual 1/16/1991

Tetrabenazine Treatment of moderate/severe tardive dyskinesia. 5/12/1998

Tetraiodothyroacetic acid 5/1/2000

Tezacitabine 1/27/2003

Oncomun Treatment of malignant glioma 6/5/2002

TGp1PTH1-34 Treatment of solitary (unicameral) bone cysts. 2/1/2007

Thalidomide Thalomid Treatment of myelodysplastic syndrome 9/27/2004

Fast Track granted by CDER. A rolling NDA submission is planned by the sponsor.

Treatment of stages IIB, IIC, III, and stage IV melanoma

For use as physiologic testosterone replacement in androgen deficient HIV+ patients with an associated weight loss.

Testosterone propionate ointment 2%

Treatment of constitutional delay of growth and puberty in boys.

Suppression of thyroid stimulating hormone in patients with well-differentiated cancer of the thyroid gland.

Treatment of adenocarcinoma of the esophagus and stomach

TGF(beta)2-specific phosphorothioate antisense oligodeoxynucleotide

Thalidomide 5/15/1995

Thalidomide Synovir Treatment of HIV-associated wasting syndrome. 3/11/1996

Thalidomide Thalomid Treatment of Crohn's disease. 4/6/1999

Thalidomide 9/19/1988

Thalidomide 9/19/1988

Thalidomide 11/15/1988

Thalidomide 1/12/1993

Thalidomide Prevention of graft versus host disease. 3/5/1990

Thalidomide Treatment of graft versus host disease. 3/5/1990

Thalidomide Treatment of primary brain malignancies. 2/27/1998

Thalidomide 5/1/1995

Thalidomide Treatment of Kaposi's sarcoma. 7/29/1998

Thiotepa Tepadina 4/2/2007

Thymalfasin Zadaxin 3/13/2006

Treatment and prevention of recurrent aphthous ulcers in severely, terminally immunocompromised patients.

Prevention of graft versus host disease in patients receiving bone marrow transplantation.

Treatment of graft versus host disease in patients receiving bone marrow transplantation.

Treatment and maintenance of reactional lepromatous leprosy.

Treatment of the clinical manifestations of mycobacterial infection caused by Mycobacterium tuberculosis and non-tuberculous mycobacteria.

Treatment of severe recurrent aphthous stomatitis in severely, terminally immunocompromised patients.

Conditioning treatment prior to hematopoietic stem cell transplantation

Treatment of stage IIb through Stage IV malignant melanoma

Thymalfasin Zadaxin Treatment of chronic active hepatitis B. 5/3/1991

Thymalfasin Zadaxin Treatment of DiGeorge anomaly with immune defects. 1/8/1998

Thymalfasin Zadaxin Treatment of hepatocellular carcinoma. 3/6/2000

Thymosin beta 4 Treatment of epidermolysis bullosa 5/28/2004

Thymoxamine HCl 11/16/1987

Tiapride Treatment of Tourette's syndrome. 4/21/1998

Chronic myelogenous leukemia (CML) 12/27/2000

Tilarginine acetate Treatment of cardiogenic shock 4/11/2005

tin ethyl etiopurpurin 11/4/2003

Tiotropium bromide Spiriva 1/8/2008

Tipifarnib Zarnestra Treatment of acute myeloid leukemia 7/6/2004

tirapazamine Treatment of head and neck cancer 10/23/2002

Tiratricol Triacana 8/13/1991

Treatment of osteonecrosis 3/13/2006

Reversal of phenylephrine-induced mydriasis in patients who have narrow anterior angles and are at risk of developing an acute attack of angle-closure glaucoma following mydriasis.

Tiazofurin (2-Beta-D-ribofuranosyl-4-thiazolecarboxamide)

Prevention of access graft disease in hemodialysis patients

To improve pulmonary function in conjunction with standard therapy in the management of patients with cystic fibrosis

For use in combination with levo-thyroxine to suppress thyroid stimulating hormone in patients with well-differentiated thyroid cancer who are intolerant to adequate doses of levo-thyroxine alone.Tissue repair cells obtained from

autologous bone marrow expanded ex vivo with a cell production system

Treatment of dilated cardiomyopathy 1/25/2007

Titanium dioxide and bisoctrizole 5/25/2005

Tizanidine HCl Zanaflex 1/31/1994

Tobramycin Tobi 6/18/1999

Fluidosomes 4/14/2009

4/15/1988

toralizumab Treatment of immune thrombocytopenic purpura 3/14/2002

Toremifene Treatment of desmoid tumors. 8/17/1993

Tosedostat Treatment of acute myeloid leukemia 12/10/2008

trabectedin Yondelis Treatment of soft tissue sarcoma. 9/30/2004

trabectedin Yondelis Treatment of patients with ovarian cancer 3/29/2005

Tramadol hydrochloride Management of postherpetic neuralgia 4/26/2005

Tramadol hydrochloride Treatment of painful HIV-associated neuropathy 1/28/2005

Tranexamic acid Cyklokapron 7/23/1987

Tissue repair cells obtained from autologous bone marrow expanded ex vivo with a cell production system

For the secondary prevention (prevention of lesional induction) of disorders with UV-A and visible light-induced photosensitivity, specifically Actinic prurigo, Hydroa vacciniforme, Solar urticara (SU), Chronic

Treatment of spasticity associated with multiple sclerosis and spinal cord injury.

For the acute and intermittent management of increased muscle tone associated with spasticity.

Treatment of bronchiectasis patients infected with Pseudomonas aeruginosa.

tobramycin liposomal for inhalation

Treatment of chronic pulmonary infection due to P. aeruginosa in cystic fibrosis patients

Tocophersolan oral solution (vitamin E-tpgs)

Treatment of vitamin E deficiency resulting from malabsorption due to prolonged cholestatic hepatobiliary disease.

Treatment of patients undergoing prostatectomy where there is hemorrhage or risk of hemorrhage as a result of increased fibrinolysis or fibrinogenolysis.

Tranexamic acid Cyklokapron Treatment of hereditary angioneurotic edema. 9/9/1985

Tranilast Rizaben For the treatment of maligant glioma 12/2/2003

Transforming growth factor-beta 2 Treatment of full thickness macular holes. 12/18/1992

5/19/1999

Trastuzumab Herceptin 12/14/1999

Treosulfan Ovastat Treatment of ovarian cancer. 5/16/1994

Tretinoin ATRA-IV Treatment of acute and chronic leukemia. 1/14/1993

Tretinoin ATRA-IV Treatment of T-cell non-Hodgkin's lymphoma 4/11/2003

Tretinoin 4/15/1985

Treatment for hepatocellular carcinoma 11/23/2001

triciribine Treatment of multiple myeloma 2/1/2008

Triheptanoin Triheptanoin-SASOL S 2/1/2008

Triheptanoin Triheptanoim-SASOl STreatment of fatty acid disorders 5/26/2006

Trimetrexate Neutrexin Treatment of metastatic osteogenic sarcoma. 8/10/2000

Trimetrexate glucuronate 1/13/1988

Trimetrexate glucuronate Treatment of pancreatic adenocarcinoma. 7/25/1985

Trimetrexate glucuronate Treatment of metastatic colorectal adenocarcinoma. 7/25/1985

Transgenic human alpha 1 antitrypsin

Treatment of emphysema secondary to alpha 1 antitrypsin deficiency.

Treatment of patients with pancreatic cancer that overexpress p185HER2.

Treatment of squamous metaplasia of the ocular surface epithelia (conjunctiva and/or cornea) with mucous deficiency and keratinization.tri-antennary glycotripeptide

derivative of 5-fluorodeoxyuridine monophosphate

Treatment of glycogen storage disorder II (Pompe disease)

Treatment of patients with advanced non-small cell carcinoma of the lung.

Trimetrexate glucuronate 7/25/1985

Triptorelin pamoate Decapeptyl Injection 8/10/1990

Trisaccharides A and B Biosynject 4/12/1987

Trisaccharides A and B Biosynject 4/15/1988

Trisaccharides A and B 8/3/1987

Trisaccharides A and B Biosynject 4/20/1987

Trisodium citrate concentration Hemocitrate For use in leukapheresis procedures. 6/15/1995

2/27/2004

Troxacitabine Troxatyl Treatment of acute myeloid leukemia 4/4/2005

1/6/1993

1/6/1993

Tyloxapol Supervent Treatment of cystic fibrosis. 3/8/1995

Treatment of diffuse systemic sclerosis 2/1/2008

tyrosine kinase inhibitor Treatment of mastocytosis 9/14/2005

Ubiquinol Ubi-Q-Nol, Li-Q-Nol Treatment of Huntington's Disease 4/12/2004

Treatment of metastatic carcinoma of the head and neck (i.e. buccal cavity, pharynx, and larynx).

For use in the palliative treatment of advanced ovarian carcinoma of epithelial origin.Treatment of moderate to severe clinical forms of hemolytic disease of the newborn arising from placental transfer of antibodies against blood group substances A and B.

Prevention of ABO medical hemolytic reactions arising from ABO-incompatible bone marrow transplantation.Treatment of moderate to very severe clinical forms of transfusion reactions arising from ABO incompatible transfusions of blood, blood products, and blood derivatives.

For use in ABO-incompatible solid organ transplantation, including kidney, heart, liver and pancreas.

Trisodium zinc Diethylenetriaminepentaacetate

Treatment of patients with known or suspected internal contamination with plutonium, americium, or curium to increase the rate of elimination.

Tumor necrosis factor-binding protein 1

Treatment of symptomatic patients with AIDS including all patients with CD4 counts less than 200 cells per mm3.

Tumor necrosis factor-binding protein II

Treatment of symptomatic patients with the AIDS including all patients with CD4 T-cell counts less than 200 cells per mm3.

Type 1 native bovine skin collagen

UBI-Q-NOL Treatment of pediatric congestive heart failure 4/12/2004

Ubiquinone Ubi-Q-Gel Treatment of mitochondrial cytopathies. 12/14/1999

Treatment of renal cell carcinoma. 3/22/2001

Urea for intravitreal injection Neurosolve Treatment of retinitis pigmentosa 12/14/2005

Uridine 5'-triphosphate 6/26/1996

Uridine 5'-triphosphate Treatment of cystic fibrosis. 12/4/1995

Urofollitropin Fertinex 12/5/1997

Urogastrone 11/1/1984

ursodiol Ursofalk Suspension Treatment of cystic fibrosis liver disease 10/23/2007

Ursodiol Actigall 2/19/1991

Valine, isoleucine and leucine VIL Treatment of hyperphenylalaninemia 1/5/1996

Ubiquinol, coenzyme Q10, ubiquinone

Unconjugated Chimeric (human-murine) G250 IgG monoclonal antibody

To facilitate the removal of lung secretions in the treatment of patients with primary ciliary dyskinesia.

For the initiation and re-initiation of spermatogenesis in adult males with reproductive failure due to hypothalamic or pituitary dysfunction, hypogonadotropic hypogonadism.

For acceleration of corneal epithelial regeneration and healing of stromal incisions from corneal transplant surgery.

Management of the clinical signs and symptoms associated with primary biliary cirrhosis.

valine-valine-ganciclovir 5/21/2007

Valproate Treatment of fragile X syndrome 5/5/2008

Valproic acid, sodium PEAC Treatment of familial adenomatous polyposis 6/24/2005

Vandetanib Zactima 10/21/2005

Vapreotide Sanvar Treatment of symptomatic carcinoid tumors 4/6/2004

vapreotide Sanvar 1/10/2000

vapreotide Octastatin Treatment of gastrointestinal and pancreatic fistulas. 1/10/2000

vapreotide Octastatin 3/6/2000

vapreotide Sanvar Treatment of acromegaly 11/4/2003

varespladib sodium 11/19/2007

VariZIG 11/7/2006

6/24/2008

Vasoactive intestinal peptide Treatment of Acute Respiratory Distress Syndrome. 3/9/2001

Vasoactive intestinal polypeptide Treatment of acute esophageal food impaction. 6/23/1993

Treatment of primary keratoconjunctivitis and recurrent epithelial keratitis due to HSV1 and HSV2.

Treatment of patients with follicular thyroid carcinoma, medullary thyroid carcinoma, anaplastic thyroid carcinoma, and locally advanced and metastatic papillary thyroid carcinoma

Treatment of esophageal variceal hemorrhage patients with portal hypertension.

Prevention of early postoperative complications following pancreatic resection.

Prevention of acute chest syndrome in at-risk patients with sickle cell disease

Varicella Zoster Immune Globulin (Human)

Passive immunization for the treatment of exposed, susceptible individuals who are at risk of complications from varicella

vascular endothelial growth factor 165b

Treatment of advanced melanoma stages IIb through IV.

veltuzumab Treatment of chronic lymphocytic leukemia 8/28/2008

Vibriolysin Vibrilase 6/16/2006

vigabatrin Sabril Treatment of infantile spasms. 6/12/2000

Viloxazine HCl Catatrol Treatment of narcolepsy. 6/11/1984

Viloxazine HCl Catatrol Treatment of cataplexy. 6/11/1984

Marqibo Treatment of acute lymphoblastic leukemia. 1/8/2007

vincristine sulfate liposomes Marqibo (r) Treatment of metastatic uveal melanoma. 6/24/2008

Virulizin Virulizin Treatment of pancreatic cancer. 2/1/2001

viscous budesonide Treatment for pediatric eosinophilic esophagitis. 12/20/2006

vistonuridine An antidote in the treatment of 5-fluorouracil poisoning. 5/1/2009

vorinostat Treatment of multiple myeloma 6/12/2003

vorinostat Treatment of mesothelioma 3/17/2004

Vx-001 2/20/2009

Xenogeneic hepatocytes HepatAssist Liver AssTreatment of severe liver failure. 11/27/1998

Debridement of severe, deep dermal burns in hospitalized patients

vincristine sulfate liposome injection

Treatment of telomerase reverse transcriptase (TERT) positive non-small cell lung cancer in HLA-A*0201 positive patients

Ferritarg P Treatment of Hodgkin's disease. 9/18/2006

Cea-Cide Treatment of ovarian carcinoma. 8/3/1999

Zalcitabine Treatment of AIDS. 12/9/1986

Zosuquidar trihydrochloride Treatment of acute myeloid leukemia 12/15/2005

Yttrium (90Y) antiferritin polyclonal antibodiesYttrium-90 radiolabeled humanized monoclonal anti-carcinoembroyonic antigen IgG antibody

Sponsor Address

Cangene Corporation CANADA

Wyeth Pharmaceuticals, Inc. P. O. Box 8299

1733 Gilsinn Lane Fenton MO 63026

Dey Laboratories Napa CA 94558

EMD Serono, Inc. One Technology Place Rockland MA 02370

Genentech, Inc. 1 DNA Way

Novo Nordisk Pharmaceuticals 100 Overlook Center Suite 200

ONY, Inc. 1576 Sweet Home Road Amherst NY 14228

Scheijdelveweg 2 NETHERLANDS

GTC Biotherapeutics, Inc. 175 Crossing Blvd Framingham MA 01702

CSL Behring, LLC 1020 First Avenue P.O. Box 61501

Antisoma 300 Technology Square Cambridge MA 02139

Genzyme Corporation 500 Kendall Street Cambridge MA 02142

GlaxoSmithKline UP 4110

104 Chancellor Matheson Road

Winnipeg, ManitobaR3T 5Y3

Philadelphia PA 19101-8299

Fleming & Company, Pharmaceuticals

2751 Napa Valley Corporate Drive

South San Francisco CA 94080-4990

Princeton NJ 08540

Dutch Ophthalmic Research Center Int'l BV

P.O. Box 43 3214ZG Zuidland

King of Prussia PA 19406

1250 South Collegeville Road

Collegeville PA 19426

Eisai Medical Research, Inc. 55 Challenger Road Ridgefield NJ 07660

ViroPharma Incorporated 730 Stockton Drive Exton PA 19341

GE Healthcare, Inc. 101 Carnegie Center Princeton NJ 08540

GE Healthcare, Inc. 101 Carnegie Center Princeton NJ 08540

Talecris 8368 US 70 West Clayton NC 27520

Amgen, Inc. One Amgen Center Drive

Prestwick Pharmaceuticals, Inc 1825 K Street NW Suite 1475

400 Morgan Lane West Haven CT 06516

Cephalon, Inc. 41 Moores Road Frazer PA 19355

Spectrum Pharmaceuticals, Inc. 157 Technology Drive Irvine CA 92618

Tarrytown NY 10591

Abbott Laboratories 200 Abbott Park Road

Thousand Oaks CA 91320-1799

Washington DC 20006

Bayer Pharmaceuticals Corporation

Regeneron Pharmaceuticals, Inc.

777 Old Saw Mill River Road

Abbott Park IL 60064-6157

Genzyme Corporation One Kendall Square

Biomarin Pharmaceutical Inc. 371 Bel Marin Blvd. Novato CA 94949

One Health Plaza

Eli Lilly and Company Lilly Corporate Center Drop Code 1853

Topo Target A/S Fruebjergvej 3, 2100 Copenhagen DENMARK

IPSEN, Inc. 27 Maple Street Milford MA 01757

Gilead Colorado 7575 West 103rd Avenue Suite 102

Novo Nordisk Inc. 100 College Road West Princeton NJ 08540

Wyeth Pharmaceuticals, Inc. P. O. Box 8299

Raritan NJ 08869

33 Hayden Avenue Lexington MA 02421

Cangene Corporation 155 Innovation Drive CANADA

Baxter Healthcare Corporation One Baxter Way

Alexion Pharmaceuticals, Inc. 352 Knotter Drive Cheshire CT 06410

Cambridge MA 02139-1562

Novartis Pharmaceutical Corporation

East Hanover NJ 07936-1080

Indianapolis IN 46285

Westminister CO 80021-5426

Phildelphia PA 19101-8299

Johnson & Johnson Pharmaceutical Research & Dev.

920 US Highway 202, P. O. Box 300

Indevus Pharmaceuticals (Formerly Valera Pharma.)

West Lake Village CA 91362

Grifols Biologicals Inc. 5555 Valley Boulevard

Salix Pharmaceuticals, Inc. Morrisville NC 27560

Merck Sante, s.a.a. 37 rue Saint Romain 69008 Lyon FRANCE

One Health Plaza

One Health Plaza

One Health Plaza

One Health Plaza

One Health Plaza

Novo Nordisk, Inc. 100 College Road West Princeton NJ 08540

Novo Nordisk, Inc. 100 College Road West Princeton NJ 08540

Merck & Co., Inc. Rahway NJ 07065-0900

Dialysis Solutions, Inc. 14 Emmett Place Whitby, Ontario L1R 2B4 CANADA

700 Main Street Cambridge MA 02139

Celgene Corporation 86 Morris Avenue Summit NJ 07901

Los Angeles CA 90032-3548

1700 Perimeter Park Drive

Novartis Pharmaceuticals Corporation

East Hanover NJ 07936-1080

Novartis Pharmaceuticals Corporation

East Hanover NJ 07936-1080

Novartis Pharmaceuticals Corporation

East Hanover NJ 07936-1080

Novartis Pharmaceuticals Corporation

East Hanover NJ 07936-1080

Novartis Pharmaceuticals Corporation

East Hanover NJ 07936-1080

P. O. Box 2000, RY 32-605

Shire Human Genetic Therapies, Inc.

Bristol-Myers Squibb Company 5 Research Parkway Wallingford CT 06492

Bristol-Myers Squibb Company 5 Research Parkway Wallingford CT 06492

Celgene Corporation 7 Powder Horn Dr. Warren NJ 07059

Centocor, Inc. Malvern PA 19355-1307

Eisai Medical Research, Inc. 6611 Tributary Street Suite 200

Genzyme Corporation 500 Kendall Street Cambridge MA 02142

Farmacon-IL, LLC 1720 Post Road East Suite 213

Astellas Pharma US, Inc. Three Parkway North Deerfield IL 60015-2548

ImClone Systems Incorporated 33 ImClone Drive Branchburg NJ 08876

Celgene Corporation 86 Morris Avenue Summit NJ 07901

400 Morgan Lane West Haven CT 06516

Insmed, Inc. Suite 200

Jazz Pharmaceuticals 3180 Porter Drive Palo Alto CA 94304

59 Route 10

200 Great Valley Parkway

Baltimore MD 21224

Westport CT 06880-5643

Bayer Pharmaceutical Corporation

8720 Stony Point Parkway

Richmond VA 23235

Novartis Pharmaceuticals Corporation

East Hanover NJ 07936-1080

GlaxoSmithKline One Franklin Plaza Phildelphia PA 19101

Tercica, Inc. Suite 400

Novo Nordisk, Inc. 100 College Road West Princeton NJ 08540

AR Holding Company, Inc. 1100 Orthodox Street Philadelphia PA 19124

900 Ridgebury Road P. O. Box 368

Novo Nordisk, Inc. 100 College Road West Princeton NJ 08540

Novo Nordisk, Inc. 100 College Road West Princeton NJ 08540

BioMarin Pharmaceutical, Inc. 105 Digital Drive Novato CA 94949-5608

Tampa FL 33637

40 Landsdowne Street Canbridge MA 02139

2000 Galloping Hill Rd. Kenilworth NJ 07033

DynPort Vaccine Company LLC Frederick MD 21702

Medicis Pharmaceutical Corp. 8125 N. Hayden Road Scottsdale AZ 85258

CoTherix, Inc. 5000 Shoreline Court

Genzyme Corporation 4545 Horizon Hill Blvd.

EMD Serono, Inc. One Technology Place Rockland MA 02370

2000 Sierra Point Parkway

Brisbane CA 94005

Boehringer Ingelheim Pharmaceuticals, Inc.

Ridgefield CT 06877-0368

Bausch & Lomb Pharmaceuticals, Inc.

8500 Hidden River Parkway

Millennium Pharmaceuticals, Inc.

Schering-Plough Reasearch Institute

64 Thomas Johnson Drive

South San Francisco CA 94080

San Antonio TX 78229-2263

Mayne Pharma (USA) Inc. Mack-Cali Centre II Second Floor

Hameln Pharmaceuticals gmbh Langes Feld 13 Hameln GERMANY

Durham NC 27713

Celgene Corporation 9900 W. 109th Street Suite 300

Presutti Laboratories, Inc. 1607 N. Douglas Ave.

Presutti Laboratories, Inc. 1607 N. Douglas Avenue

Ipsen Limited 190 Bath Road Slough, Berkshire SL1 3XE UNITED KINGDOM

Amgen, Inc. One Amgen Center Drive

Eli Lilly and Company Lilly Corporate Center Indianapolis IN 46285

209 10th Street South Suite 332

EMD Serono, Inc. One Technology Place Roackland MA 02370

2151 Berkeley Way Berkeley CA 94704-1011

Goerzallee 253 GERMANY

Paramus NJ 07652

Nutritional Restart Pharmaceutical, L.P.

4364 South Alston Avenue

Overland Park KS 66210

Arlington Heights IL 60004

Arlington Heights IL 60004

Thousand Oaks CA 91320-1799

Cumberland Pharmaceuticals, Inc.

Nashville TN 37203

California Department of Health Services

Heyl Chemisch-Pharmzeutische Fabrik GMBH & Co, KG

D-14167 Berlin, Federal Republic of Germany

Axcan Scandipharm Inc. 22 Inverness Parkway Suite 310

Actelion Pharmaceuticals Ltd Gewerbestrasse 16 CH - 4123 Allschwi SWITZERLAND

Schering Corporation 2000 Galloping Hill Road Kenilworth NJ 07033

GlaxoSmithKline 2301 Renaissance Blv. P.O. Box 61540

40 Landsdowne Street Cambridge MA 02139

BioMarin Pharmaceutical, Inc. Novato CA 94949-5608

Genzyme Corporation One Kendall Square

Sensus Corporation Suite 430, 98 San Jacinto Boulevard

Guilford Pharmaceuticals, Inc. 6611 Tributary Street Baltimore MD 21224

Baxter Healthcare Corporation Renal Division 1620 Waukegan Road

Romark Laboratories, L.C. Suite 880

Romark Laboratories, L.C. Suite 880

ChiRhoClin, Inc. 15500 Gallaudet Ave.

1901 Huguenot Road Richmond VA 23235

Birmingham AL 35242

King of Prussia PA 19406-2772

Millennium Pharmaceuticals, Inc.

371 Bel Marin Keys Boulevard, Suite 210

Cambridge MA 02139-1562

Austin TX 78701

McGaw Park IL 60085

6200 Courtney Campbell Causeway

Tampa FL 33607

6200 Courtney Campbell Causeway

Tampa FL 33607

Silver Spring MD 20905-4176

Reckitt Benckiser Pharmaceuticals, Inc.

1901 Huguenot Road Richmond VA 23235

Jazz Pharmaceuticals 3180 Porter Drive Palo Alto CA 94304

Sanofi-Synthelabo Research 9 Great Valley Parkway Malvern PA 19355

United Therapeutics Corp. 68 T.W. Alexander Dr. P.O. Box 14186

ChiRhoClin, Inc. 15500 Gallaudet Ave.

ChiRhoClin, Inc. 15500 Gallaudet Ave.

Cell Therapeutics, Inc. 501 Elliott Ave. W. Suite 400

Novartis Pharmaceuticals Corp. One Health Plaza

Swedish Orphan AB Drottninggatan 98 SE-111 60 Stockholm SWEDEN

Actelion Life Sciences Ltd. 1840 Gateway Dr. 2nd Floor

Route 202, P.O. Box 300 Raritan NJ 08869-0602

Novartis Pharmaceuticals Corp. 59 Route 10

7000 Portage Road Kalamazoo MI 49001

59 Route 10

Reckitt Benckiser Pharmaceuticals, Inc.

Research Triangle Park NC 27709

Silver Spring MD 20905-4176

Silver Spring MD 20905-4176

Seattle WA 98119

East Hanover NJ 07936-1080

San Mateo CA 94404

Johnson & Johnson Pharmaceutical R & D, LLC

East Hanover NJ 07936-1080

Pharmacia and Upjohn Company

Novartis Pharmaceuticals Corporation

East Hanover NJ 07936-1080

Genzyme Corporation 4545 Horizon Hill Blvd.

Allergan, Inc. 2525 Dupont Drive P.O. Box 19534

Solstice Neurosciences, Inc. 40 General Warren Blvd Suite 160

Jazz Pharmaceuticals 3180 Porter Drive Palo Alto CA 94304

Serono, Inc. One Technoloogy Place Rockland MA 02370

Serono, Inc. One Technology Place Rockland MA 02370

Protherics, Inc. Nashville TN 37212

Cephalon 41 Moores Road PO Box 4011

Pharmacia & Upjohn 7000 Portage Rd. 0633-298-113

EMD Serono, Inc. One Technology Place Rockland MA 02370

Wyeth-Ayerst Laboratories PO Box 8299

GlaxoSmithKline Five Moore Dr. PO Box 13398

InterMune , Inc. 1710 Gilbreth Road, Suite 301

Eisai Medical Research, Inc. 55 Challenger Road Ridgefield Park NJ 07660

San Antonio TX 78229-2263

Irvine CA 92623-9534

Malvern PA 19355

1207 17th Ave. S., Suite 103

Frazer PA 19355

Kalamazoo MI 49001-0199

Philadelphia PA 19101-8299

Research Triangle Park NC 27709-3398

Burlingame CA 94010-1317

INO Therapeutics, Inc. 54 Old Highway 22 Clinton NJ 08809

9841 Washingtonian Blvd Suite 500

Pharmacia & Upjohn 7000 Portage Road Mail Stop: 0636-298-113

O.P.R. Development, L.P. 1501 Wakarusa Drive Lawrence KS 66047

Pharmacia & Upjohn Company 0634-298-113 7000 Portage Rd.

2000 Galloping Hill Rd. Kenilworth NJ 07033

Alza Corporation 1550 Plymouth St. PO Box 7210

Medimmune Oncology, Inc. One Tower Bridge 100 Front Street, Suite 400

Immunex Corporation 51 University St. Seattle WA 98101-2936

Aventis Behring L.L.C. 1020 First Avenue PO Box 61501

Pacira Pharmaceuticals, Inc. San Diego CA 92121

Novo Nordisk, Inc. 100 Overlook Center Suite 200

Teikoku Pharma USA, Inc. 745-D Camden Ave. Campbell CA 95008-4146

Eisai Medical Research, Inc. 55 Challenger Road Ridgefield Park NJ 07660

Sigma-Tau Pharmaceuticals, Inc.

Gaithersburg MD 20878

Kalamazoo MI 49001-0199

Kalamazoo MI 49001-0199

Schering-Plough Research Institute

Mountain View CA 94039-7210

Conshohocken PA 19428

King Of Prussia PA 19406-0901

10450 Science Center Drive

Princeton NJ 08540-7810

Tokyo JAPAN

Eisai Medical Research, Inc 55 Challenger Road Ridgefield Park NJ 07660

5 Moore Drive PO Box 13398

Cephalon, Inc. 145 Brandywine Parkway West Chester PA 19380

305 South Street Boston MA 02130-3597

Genzyme Corporation One Kendall Square Cambridge MA 02139

59 Route 10

59 Route 10

59 Route 10

Anthra Pharmaceuticals, Inc. Princeton NJ 08540

Centocor, Inc. Malvern PA 19355-1307

5 Moore Drive P.O. Box 13398

Celgene Corporation 86 Morris Avenue Summit NJ 07901

Otsuka Pharmaceutical Company

Glaxo Wellcome Research and Development

Research Triangle Park NC 27709

Massachussetts Public Health Biologic Laboratories

Novartis Pharmaceuticals Corporation

East Hanover NJ 07936-1080

Novartis Pharmaceuticals Corporation

East Hanover NJ 07936-1080

Novartis Pharmaceuticals Corporation

East Hanover NJ 07936-1080

103 Carnegie Center, Suite 102

200 Great Valley Parkway

Glaxo Wellcome Research and Development

Research Triangle Park NC 27709

Hoechst Marion Roussel P.O. Box 9627 Mail Station: H3-M2516

Mylan Laboratories, Inc. 781 Chestnut Ridge Road P.O. Box 4310

59 Route 10

QOL Medical, LLC 12419 198th Drive, NE Woodinville WA 98072

Amgen, Inc. One Amgen Center Dr.

Hoechst Marion Roussel Frankfurt am Main P.O. Box 1140 Marburg GERMANY

P.O. Box 4000 Princeton NJ 08543

MGI Pharma, Inc. Suite 100

Chiron Corporation 4560 Horton Street

Bryan Corporation 4 Plympton Street Woburn MA 01801

Novartis Pharmaceuticals Corp Drug Regulatory Affairs One Health Plaza

Genentech, Inc.

Hoffmann-La Roche, Inc. 340 Kingsland Street Nutley NJ 07110

Axcan Pharma Inc. 597 Laurier Blvd

Kansas City MO 64134-0627

Morgantown WV 26504-4310

Novartis Pharmaceuticals Corporation

East Hanover NJ 07936-1080

Thousand Oaks CA 91320-1799

Bristol-Myers Squibb Pharmaceutical Research Institute

5775 West Old Shakopee Rd.

Bloomington MN 55437-3107

Emeryville CA 94608-2916

East Hanover NJ 07936-1080

460 Point San Bruno Boulevard

South San Francisco CA 94080

Mount St. Hilaire Quebec H7L 4S3

Jazz Pharmaceuticals 3180 Porter Drive Palo Alto CA 94304

Genentech, Inc. 1 DNA Way, MS 242

Genetics Institute, Inc. 87 Cambridge Park Drive Cambridge MA 02140

Pharmacia & Upjohn 7000 Portage Road

EMD Serono, Inc. One Technology Place Rockland MA 02370

Fujisawa USA, Inc. 3 Parkway North Center Deerfield IL 60015

Fujisawa USA, Inc. 3 Parkway North Center Deerfield IL 60015

5 Research Parkway P.O. Box 5100

Valeant Pharmaceuticals 3300 Hyland Avenue Costa Mesa CA 92626

Orion Corporation P.O. Box 65 02101 ESPOO FINLAND

Roberts Pharmaceutical Corp. Meridian Center III 6 Industrial Way West

Genetics Institute, Inc. 87 Cambridge Park Drive Cambridge MA 02140

Lemmon Company 1510 Delp Drive Kulpsville PA 19443

Eli Lilly and Company Lilly Corporate Center Indianapolis IN 46285

Genentech, Inc.

South San Francisco CA 94080-4990

Kalamazoo MI 49001-0199

Bristol-Myers Squibb Pharmaceutical Research Institute

Wallingford CT 06492-7660

Eatontown NJ 07724

460 Point San Bruno Boulevard

South San Francisco CA 94080

Teva Pharmaceuticals USA 1510 Delp Drive Kulpsville PA 19443

Serono One Technology Place Rockland MA 02370

Jazz Pharmaceuticals 3180 Porter Drive Palo Alto CA 94304

Liposome Company, Inc. One Research Way Princeton NJ 08540

Roxane Laboratories, Inc. PO Box 16532

QOL Medical, LLC 12419 198th Drive, NE Woodinville WA 98072

Alza Corporation 950 Page Mill Rd. PO Box 10950

Guilford Pharmaceuticals, Inc. 6611 Tributary Street Baltimore MD 21224

Meridian Center III 6 Industrial Way West

EMD Serono, Inc. One Technology Place Rockland MA 02370

Warner-Lambert Company 2800 Plymouth Road Ann Arbor MI 48106

One Franklin Plaza P.O. Box 7929

One Franklin Plaza P.O. Box 7929

Ferring Laboratories, Inc. Suffern NY 10901

Allergan, Inc. 2525 Dupont Drive P.O. Box 19534

Columbus OH 43216-6532

Palo Alto CA 94303-0802

Schier Ridgewood F.K.A. (Roberts Pharmaceutical Corp.)

Eatontown NJ 07724

SmithKline Beecham Pharmaceuticals

Philadelphia PA 19101

SmithKline Beecham Pharmaceuticals

Philadelphia PA 19101

400 Rella Boulevard, Suite 201

Irvine CA 92713

Catalytica Pharmaceuticals, Inc PO Box 1887 Greenville NC 27835-1887

Biogen, Inc. 14 Cambridge Center Cambridge MA 02142

Medicis Pharmaceutical Corp. 8125 N. Hayden Road Scottsdale AZ 85258

NeXstar Pharmaceuticals, Inc. 650 Cliffside Drive San Dimas CA 91773

9342 Jeronimo Road Irvine CA 92718-1903

P.O. Box 4000 Princeton NJ 08543

Gaithersburg MD 20878

Amgen, Inc. 1840 Dehavilland Drive

QLT Phototherapeutics, Inc. Lederle Laboratories

Collegeville PA 19426

Medimmune Oncology, Inc. One Tower Bridge 100 Front Street, Suite 400

Hoffmann-La Roche, Inc. 340 Kingsland Street Nutley NJ 07110

Hoffmann-La Roche, Inc. 340 Kingsland Street Nutley NJ 07110

Glaxo Wellcome Inc. 5 Moore Drive

Bausch & Lomb Surgical, Chiron Vision Products

Bristol-Myers Squibb Pharmaceutical Research Institute

MedImmune & Massachussetts Public Health Biologics Labs.

35 West Watkins Mill Road

Thousand Oaks CA 91320

401 North Middletown Road

Pearl River NY 10965

Rhone-Poulenc Rorer Pharmaceuticals, Inc.

500 Arcola Road, P.O. Box 1200

West Conshohocken PA 19428

Research Triangle Park NC 27709

Immunex Corporation 51 University Street Seattle WA 98101

Wyeth-Ayerst Laboratories P.O. Box 8299 Philadelphia PA 19101

Pharmacia & Upjohn 7000 Portage Road

Rh Pharmaceuticals, Inc. Winnipeg, Manitoba CANADA

Amgen, Inc. 1840 Dehavilland Drive

Mylan Laboratories, Inc. 781 Chestnut Ridge Road P.O. Box 4310

Eon Labs Manufacturing, Inc. Laurelton NY 11413

37 Cleveland Lane P.O. Box 5290

Amgen, Inc. 1840 Dehavilland Drive

Hoechst Marion Roussel P.O. Box 9627 Kansas City MO 64134

Genzyme Corporation One Kendall Square

MGI Pharma, Inc. Suite 100

Aventis Behring L.L.C. 1020 First Avenue PO Box 61501

Enzon, Inc. 20 Kingsbridge Road Piscataway NJ 08854

Kalamazoo MI 49001-0199

104 Chancellor Matheson Road

Thousand Oaks CA 91320

Morgantown WV 26504

227-15 North Conduit Avenue

Jacobus Pharmaceutical Company

Princeton NJ 08540

Thousand Oaks CA 91320

Cambridge MA 02139-1562

5775 West Old Shakopee Rd.

Bloomington MN 55437-3107

King of Prussia PA 19406-0901

Genentech, Inc.

Bayer Corporation Pharmaceutical Division 400 Morgan Lane

Bayer Corporation 400 Morgan Lane

Medimmune Oncology, Inc. One Tower Bridge 100 Front Street, Suite 400

Genentech, Inc.

Alcon Laboratories, Inc. 6201 South Freeway Fort Worth TX 76134

Evansville IN 47721

Wallace Laboratories 301B College Road East Princeton NJ 08540

4560 Horton Street Emeryville CA 94608

Biodevelopment Corporation McLean VA 22102

Tap Pharmaceuticals, Inc. 2355 Waukegan Road Deerfield IL 60015

Route 202, P.O. Box 300 Raritan NJ 08869

Bayer Corporation 1884 Miles Avenue Elkhart IN 46515

Cytogen Corporation 600 College Road East Princeton NJ 08540

Adria Laboratories, Inc. P.O. Box 16529 Columbus OH 43216

460 Point San Bruno Boulevard

South San Francisco CA 94080

West Haven CT 06516

Pharmaceutical Division, Biological Products

New Haven CT 06516

West Conshohocken PA 19428

460 Point San Bruno Boulevard

South San Francisco CA 94080

Bristol-Myers Squibb Pharmaceutical Research Institute

2400 West Lloyd Expressway

Chiron Corp. & Berlex Laboratories

8180 Greensboro Drive, Suite 1000

R. W. Johnson Pharmaceutical Research Institute

Unimed Pharmaceuticals, Inc. 901 Sawyer Rd. Marietta GA 30062

Suite 500

Glaxo Wellcome Inc. 5 Moore Drive

Glaxo Wellcome Inc. 5 Moore Drive

Berlex Laboratories, Inc. 300 Fairfield Road Wayne NJ 07470

Collegeville PA 19426

One Franklin Plaza P.O. Box 7929

5 Research Parkway P.O. Box 5100

Medtronic, Inc. 800 53rd Avenue N.E. Minneapolis MN 55432

Hoffmann-La Roche, Inc. 340 Kingsland Street Nutley NJ 07110

Chiron Corporation 4560 Horton Street

Syntex (USA), Inc. 3401 Hillview Avenue Palo Alto CA 94303

One Franklin Plaza P.O. Box 7929

Sigma-Tau Pharmaceuticals, Inc.

9841 Washingtonian Blvd.

Gaithersburg MD 20878

Research Triangle Park NC 27709

Research Triangle Park NC 27709

Armour Pharmaceutical Company

500 Arcola Road, P.O. Box 1200

SmithKline Beecham Pharmaceuticals

Philadelphia PA 19101

Bristol-Myers Squibb Pharmaceutical Research Institute

Wallingford CT 06492

Emeryville CA 94608-2916

SmithKline Beecham Pharmaceuticals

Philadelphia PA 19101

Bayer Corporation 400 Morgan Lane

Roberts Pharmaceutical Corp. Meridian Center III 6 Industrial Way West

Immunex Corporation 51 University Street Seattle WA 98101

SuperGen, Inc. 4140 Dublin Blvd. Suite 200

Elkins-Sinn, Inc. 2 Esterbrook Lane Cherry Hill NJ 08003

Ross Laboratories 625 Cleveland Avenue Columbus OH 43215

Ross Laboratories 625 Cleveland Avenue Columbus OH 43215

Berlex Laboratories, Inc. Richmond CA 94804

Genzyme Corporation One Kendall Square

Immunex Corporation 51 University Street Seattle WA 98101

Solopak Pharmaceutical Co. 1845 Tonne Road

Alpha Therapeutic Corporation 5555 Valley Boulevard Los Angeles CA 90032

Amgen, Inc. 1840 Dehavilland Drive

Medimmune Oncology, Inc. One Tower Bridge 100 Front Street, Suite 400

InterMune, Inc. 3280 Bayshore Blvd Brisbane CA 94005

920 Winter Street Waltham MA 02451

Pharmaceutical Division, Biological Products

New Haven CT 06516

Eatontown NJ 07724

Dublin CA 94568

15049 San Pablo Avenue, P.O. Box 4099

Cambridge MA 02139-1562

Elk Grove Village IL 60007

Thousand Oaks CA 91320

Conshohocken PA 19428

Fresenius Medical Care North America

Hoechst Marion Roussel P.O. Box 9627 Kansas City MO 64134

United-Guardian, Inc. P.O. Box 2500 Smithtown NY 11787

Adria Laboratories, Inc. P.O. Box 16529 Columbus OH 43216

Glaxo Wellcome Inc. 5 Moore Drive

Glaxo Wellcome Inc. 5 Moore Drive

University of Michigan UH B1 H410/0028

Enzon, Inc. 20 Kingsbridge Road Piscataway NJ 08854

Allergan, Inc. 2525 Dupont Drive P.O. Box 19534

Allergan, Inc. 2525 Dupont Drive P.O. Box 19534

Fisons Corporation 755 Jefferson Rd P.O. Box 1710

Pharmacia & Upjohn AB Lindhagensgatan 133 SE-112 87 SWEDEN

Ferring Laboratories, Inc. Suffern NY 10901

Syntex (USA), Inc. 3401 Hillview Avenue Palo Alto CA 94304

Research Triangle Park NC 27709

Research Triangle Park NC 27709

1500 E. Medical Center Drive

Ann Arbor MI 48109-0028

Irvine CA 92713

Irvine CA 92713

Rochester NY 14603

400 Rella Boulevard, Suite 201

Fujisawa USA, Inc. 3 Parkway North Center Deerfield IL 60015

Somerset Pharmaceuticals, Inc. Tampa FL 33602

Amgen, Inc. 1840 Dehavilland Drive

Hoechst Marion Roussel P.O. Box 9627 Kansas City MO 64134

Hoffmann-La Roche, Inc. 340 Kingsland Street Nutley NJ 07110

Hoffmann-La Roche, Inc. 340 Kingsland Street Nutley NJ 07110

Wallingford CT 06492

Degussa Corporation 65 Challenger Road Ridgefield Park NJ 07660

Block Drug Company, Inc. 257 Cornelison Avenue Jersey City NJ 07302

Bock Pharmacal Company P.O. Box 419056

Galderma Laboratories, Inc. P.O. Box 331329 Fort Worth TX 76163

Hoffmann-La Roche, Inc. 340 Kingsland Street Nutley NJ 07110

Schering Corporation 2000 Galloping Hill Road Kenilworth NJ 07033

Immunex Corporation 51 University Street Seattle WA 98101

777 South Harbor Island Boulevard

Thousand Oaks CA 91320

Bristol-Myers Squibb Pharmaceutical Research Institute

5 Research Parkway, P.O. Box 5100

Saint Louis MO 63141-9056

Pak, Charles Y.C. M.D.

Lederle Laboratories 401 N. Middletown Road

2525 McGaw Avenue P.O. Box 19791

Lederle Laboratories 401 N. Middletown Road

500 Arcola Road Collegeville PA 19426

Bayer Corporation 400 Morgan Lane

Du Pont Pharmaceuticals Wilmington DE 19898

MGI Pharma, Inc. Suite 100

Glaxo Wellcome Inc. 5 Moore Drive

Glaxo Wellcome Inc. 5 Moore Drive

Eli Lilly and Company Lilly Corporate Center Indianapolis IN 46285

Pharmacia Inc. P.O. Box 16529 Columbus OH 43216

59 Route 10 East Hanover NJ 07936

59 Route 10 East Hanover NJ 07936

EMD Serono, Inc. One Technology Place Rockland MA 02370

The University of Texas Health Scienc Center at Da

5323 Harry Hines Boulevard

Dallas TX 75235

Division of American Cyanamid Company

Pearl River NY 10965

Immunex

ImmunexIrvine CA 92623

Division of American Cyanamid Company

Pearl River NY 10965

Rhone-Poulenc Rorer Pharmaceuticals, Inc.

Pharmaceutical Division, Biological Products

New Haven CT 06516

E.I. Du Pont De Nemours & Co.

5775 West Old Shakoppe Rd.

Bloomington MN 55437-3107

Research Triangle Park NC 27709

Research Triangle Park NC 27709

Novartis Pharmaceutical Corporation

Novartis Pharmaceutical Corporation

Glaxo Wellcome Inc. 5 Moore Drive

9841 Washingtonian Blvd Suite 500

West Point PA 19486

Ethitek Pharmaceuticals, Inc. Skokie IL 60077

Genentech, Inc.

Genentech, Inc.

5323 Harry Hines Blvd Dallas TX 75235

5323 Harry Hines Blvd Dallas TX 75235

Dallas TX 75235

DuPont Pharmaceuticals Wilmington DE 19880

Fujisawa USA, Inc. 3 Parkway North Center Deerfield IL 60015

Fisons Corporation 755 Jefferson Rd. P.O. Box 1710

Solvay 901 Sawyer Road Marietta GA 30062

Abbott Laboratories Diagnostics Division Abbott Park IL 60064

Research Triangle Park NC 27709

Sigma-Tau Pharmaceuticals, Inc.

Gaithersburg MD 20878

Merck Sharp & Dohme Research

Division Of Merck And Company

7855 Gross Point Road, Unit L

460 Point San Bruno Boulevard

South San Francisco CA 94080

460 Point San Bruno Boulevard

South San Francisco CA 94080

University of Texas Health Science Center at Dallas

University of Texas Health Science Center at Dallas

University of Texas Health Science Center at Dallas

5323 Harry Hines Boulevard

E.I. Du Pont De Nemours & Co.

Rochester NY 14603

Intarcia Therapeutics, Inc. 24650 Industrial Blvd Hayward CA 94545

Marshall Edwards, Inc. 140 Wicks Road AUSTRALIA

Marshal Edwards, Inc. 140 Wicks Road AUSTRALIA

Marshall Edwards, Inc. 140 Wicks Road AUSTRALIA

Genzyme Corporation 500 Kendall Street Cambridge MA 02142

Tibotec, Inc. 1020 Stony Hill Road Yardley PA 19067

BioCryst Pharmaceuticals, Inc. 2190 Parkway Lake Drive Birmingham AL 35244

BioCryst Pharmaceuticals, Inc. 2190 Parkway Lake Drive Birmingham AL 35244

BioCryst Pharmaceuticals, Inc. 2190 Parkway Lake Drive Birmingham AL 35244

Fujisawa Healthcare, Inc. Three Parkway North Deerfield IL 60015-2548

80 Broad Street New York NY 10004

50 Pequot Avenue New London CT 06320

Sigma-Tau Research, Inc. 9841 Washingtonian Blvd Suite 502

Adventrx Pharmaceuticals, Inc. 6725 Mesa Ridge Road Suite 100

100 Cummings Center Beverly MA 01915

Global Alliance for TB Drug Development

Pfizer Global Research and Development

Gaithersburg MD 20878

San Diego CA 92121

Inotek Pharmaceuticals Corporation

2440 Research Blvd Rockville MD 20850

Abbott Laboratories 200 Abbott Park Road AP34/RA72

Abbott Laboratories 200 Abbott Park Road Abbott Park IL 60064

Abbott Laboratories 200 Abbaott Park Road AP34/RA72

Phase 2 Discovery, Inc. Cincinnati OH 45219-2374

Phase 2 Discovery, Inc. 3130 Highland Ave. Third Floor

Ferrokin BioSciences, Inc. 2729 Debbie Court San Carlos CA 94070

Auris Medical, Inc. 211 East Ontario Street Chicago IL 60611

Winston Laboratories, Inc. 100 Fairway Drive Vernon Hills IL 60061

160 Second Street Cambridge MA 02142

Aeolus Pharmaceuticals, Inc. 4401 Research

BioSynthema, Inc. 4041 Forest Park Avenue St. Louis MO 63108

Clinuvel Inc. 353 Sacramento Street San Francisco CA 94111

Oxford GlycoSciences 10, The Quadrant Abington Science Park UNITED KINGDOM

Otsuka Pharmaceutical Company, Ltd

Abbott Park IL 60064-6188

Abbott Park IL 60064-6188

3130 Highland Avenue, Third Floor

Cincinnati OH 45219

Molecular Insight Pharmaceuticals, Inc.

PO Box 14287; 79 T.W. Alexander Dr.

Research Triangle Park NC 27709

United Kingdom

S*BIO Pte., Ltd. 1 Science Park Road Singapore Science Park II SINGAPORE

1600 Canal St. 10th Floor

NeoRx Corporation 410 W. Harrison Street Seattle WA 98119-4007

Hologic, Inc. 1240 Elko Drive Sunnyvale CA 94089

Bristol-Myers Squibb Company Research & Development 5 Research Parkway

Amicus Therapeutics, Inc. 6 Cedar Brook Drive Cranbury NJ 08512

Amicus Therapeutics, Inc 6 Cedar Brook Drive Cranbury NJ 08512

101 Federal Street Boston MA 02110

EntreMed, Inc. Rockville MD 20850

EntreMed, Inc. Suite 400

FoldRx Pharmaceuticals, Inc. 300 Technology Square Cambridge MA 02139

Callisto Pharmaceuticals, Inc. 2 Executive Drive Suite 450

Callisto Pharmaceuticals, Inc. 420 Lexington Avenue New York NY 10170

Repligen Corporation 41 Seyon Street Building 1, Suite 100

Louisiana State University Medical Center Foundation

New Orleans LA 70112

Wallingford CT 06492-7660

HemaQuest Pharmaceuticals, Inc.

9640 Medical Center Drive

Research Triangle Park Center

Durham NC 27703

Somerset NJ 08873

Waltham MA 02453

Knopp Neurosciences, Inc. 2100 Wharton Street Pittsburgh PA 15203

BioQuant, Inc. 6330 Nancy Ridge Drive San Diego CA 92121

Abbott Laboratories 200 Abbott Park Road

Abbott Laboratories Abbott Park IL 60064

Inologic, Inc. 101 Elliott Ave., West Seattle WA 98119

Kennedy & Hoidal, M.D.'s

Rexahn Corporation Rockville MD 20850

Rexahn Corporation Rockville MD 20850

Rexahn Corporation Rockville MD 20850

Rexahn Corporation Rockville MD 20850

Rexahn Corporation Rockville MD 20850

National Cancer Institute, Dct Bethesda MD 20892

Lemmon Company 1510 Delp Drive Kulpsville PA 19443

Lawrence Panasci, MD 3755 Cote Ste Catherine CANADA

Global Pharmaceutical Research and Development

Abbott Park IL 60064-6157

Global Pharmaceutical Research and Development

University of Utah Health Sciences Center

50 North Medical Drive, Room 4R240

Salt Lake City UT 84132

9620 Medical center Drive

9620 Medical Center Drive

9620 Medical center Drive

9620 Medical Center Drive

9620 Medical Center Drive

NIH, Exec. Plaza N., Room 7-18

Professor of Medicine, McGill University

Montreal, Quebec H3T 1E2

Pangene Corporation 5500 Stewart Avenue Fremont CA 94538

Grant, Steven M.D. P.O. Box 980230

Neurophyxia B.V. Onderwijsboulevard 219 NETHERLANDS

PR Pharmaceuticals, Inc. 1716 Heath Parkway Fort Collins CO 80524

EntreMed, Inc. Rockville MD 20850

EntreMed, Inc. Rockville MD 20850

EntreMed, Inc. Rockville MD 20850

Prosena B.V. Einsteinweg 55 NETHERLANDS

Sugen, Inc. 230 East Grand Ave.

Sugen, Inc. 230 East Grand Ave.

37 Cleveland Avenue P.O. Box 5290

Elliot Danforth, Jr., M.D. University of Vermont 84 Beartown Road

PTC Therapeutics, Inc. 100 Corporate Court South Plainfield NJ 07080

PTC Therapeutics 100 Corporate Court South Plainfield NJ 07080

PTC Therapeutics, Inc. 100 Corporate Court South Plainfield NJ 07080

Massey Cancer Center, VCU

Richmond VA 23298-0230

9640 Medical Center Drive

9640 Medical Center Drive

9640 Medical Center Drive

South San Francisco CA 94080

South San Francisco CA 94080-4811

Jacobus Pharmaceutical Company

Princeton NJ 08540

Underhill VT 05489

Berlex Laboratories, Inc. Alameda CA 94501

Seaside Therapeutics 840 Memorial Drive Cambridge MA 02139

Dynogen Pharmaceuticals, Inc. 52 Second Avenue Waltham MA 02451

NeuroSearch Sweden AB Scerige Pederstrupvej 93 SWEDEN

Kiadis Pharma Canada, Inc. 2525 Marie Curie Canada H4S 2E1 CANADA

Kiadis Pharma Canada, Inc. 2525 Marie Curie CANADA

Kiadis Pharma Canada, Inc. 2525 Marie Curie Canada H4S 2E1 CANADA

Kiadis Pharma Canada, Inc. 2525 Marie-Curie CANADA

Thallion Pharmaceuticals, Inc. 7150 Alexander-Fleming CANADA

Conatus Pharmaceuticals, Inc. 4365 Executive Drive San Diego CA 92121

SuperGen, Inc. 4140 Dublin Blvd Dublin CA 94568

Biomedical Frontiers, Inc. 1095 10th Ave., S.E. Minneapolis MN 55414

LaJolla CA 92037

Acorda Therapeutics, Inc. 15 Skyline Drive Hawthorne NY 10532

37 Cleveland Lane Princeton NJ 08540

1401 Harbor Bay Parkway

Saint-Laurent (Quebec) H4S 2E1

Metabasis Therapeutics, Incorporated

11119 North Torrey Pines Road

Jacobus Pharmaceutical Co., Inc.

Beeken, Warren M.D. University Of Vermont Given C-317

Trophos SA 1322 Marseille cedex FRANCE

920 U S Highway 202 P.O. Box 300

SIGA Technologies, Inc. 4575 SW Research Way Suite 230

SIGA Technologies, Inc. 4575 SW Research Way Suite 230

Guerickestrasse 25 80805 Munich, GERMANY

Reata Pharmaceuticals, Inc. Dallas TX 75207-3199

Now Pharm AG 241, route d'Arlon L-1150 LUXEMBOURG

ILEX Oncology, Inc. 4545 Horizon Hill Blvd.

Humanetics, Inc. 10400 Viking Drive Eden Prairie MN 55344

Sirtris Pharmaceuticals, Inc. 200 Technology Square Cambridge MA 02139

GlaxoSmithKline Five Moore Dr. P.O. Box 13398

Biogen, Inc. 14 Cambridge Center Cambridge MA 02142

SuperGen, Inc. 4140 Dublin Blvd. Suite 200

Burlington VT 05405

Parc scientifique de Lumigny, Case 931

Johnson & Johnson Pharmaceutical Research & Dev,

Raritan NJ 08869

Corvallis OR 97333

Corvallis OR 97333

ClinTec International Ltd./Caledonia Pharma Ltd.

1950 N. Stemmons Freeway

San Antonio TX 78229-2263

Research Triangle Park NC 27709-3398

Dublin CA 94568

Celgene Corporation 9900 W. 109th Street Suite 300

Xechem International, Inc. Building 1, Suite 310

Hana Biosciences, Inc. 7000 Shoreline Court Suite 370

InterMune, Inc. 3280 Bayshore Blvd Brisbane CA 94005

Clavis Pharma ASA Parkveien 53 B NORWAY

Intercept Pharmaceuticals, Inc. 18 Desbrosses Street New York NY 10013

25 Health Science Drive Stony Brook NY 11790

Intercept Pharmaceuticals, Inc. 18 Desbrosses Street New York NY 10013

Eisai Medical Research, Inc. 55 Challenger Road Ridgefield Park NJ 07660

Therakos, Inc. 437 Creamery Way

Therakos, Inc. 437 Creamery Way

Immunomedics, Inc. 300 American Road Morris Plains NJ 07950

Allergan, Inc. 2525 Dupont Drive P.O. Box 19534

SuperGen, Inc. 4140 Dublin Blvd. Suite 200

NovoMed Pharmaceuticals, Inc. P.O. Box 900

Overland Park KS 66210

New Brunswick Technoloogy Center

New Brunswick NJ 08901-3279South San Francisco CA 94080

Cornerstone Pharmaceuticals, Inc.

Oaklands Corporate Center

Exton PA 19341

Oaklands Corporate Center

Exton PA 19341

Irvine CA 92623-9534

Dublin CA 94568

Germantown MD 20875-0900

Celgene Corporation 7 Powder Horn Drive

9432 Old Katy Road Houston TX 77055

Philadelphia PA 19104

La Jolla Pharmaceutical Co. 6455 Nancy Ridge Dr. San Diego CA 92121

Menarini Ricerche S.p.A. Via Tito Speri 10 Pomezia Roma ITALY

Bristol-Myers Squibb Company P.O. Box 4500 Princeton NJ 08543-4500

Genzyme Corporation 500 Kendall Street Cambridge MA 02142

Abbott Laboratories 200 Abbott Park Road

P. O. Box 22506 NETHERLANDS

Avigen, Inc. Alameda CA 94502

Avigen, Inc. Alameda CA 94502

11801 Research Drive Alachua FL 32615

11801 Research Drive Alachua FL 32615

Warren NJ 07059

Burzynski Research Institute, Inc.

Center for Cellular & Molecular Therapeutics

The Children's Hospital of Philadelphia

Abbott Park IL 60064-6188

Amsterdam Molecular Therapeutics BV

1301 Harbor Bay Parkway

1301 Harbor Bay Parkway

Applied Genetic Technologies Corporation

Applied Genetic Technologies Corporation

Fondazione Telethon ITALY

Targeted Genetics Corporation Seattle WA 98101

Medco Research, Inc. 8455 Beverly Boulevard Suite 308

Advantagene, Inc. 160 Paulson Road Waban MA 02468

10835 Altman Row Suite 150

Ark Therapeutics Ltd 6 Warren Mews London W1T6AR London UNITED KINGDOM

Pediatric Pharmaceuticals, Inc. 718 Bradford Avenue Westfield NJ 07090

Alpha Gal, LLC 3700 Airpark Drive

TolerRX, Inc. 300 Technology Square Cambridge MA 02139

AutoImmune, Inc. 128 Spring Street Lexington MA 02173

MotoGen, Inc. 3 Pine View Road Mount Kisco NY 10549

Aldagen, Inc. 2810 Meridian Parkway Durham NC 27713

Chiron Corporation 4560 Horton Street

Chiron Corporation 4560 Horton St.

Via Guglielmo Saliceto, 5/a

1100 Olive Way, Suite 100

Los Angeles CA 90048

GenStar Therapeutics Corporation

San Diego CA 92121

a Kentucky Bioprocessing (KBP) subsidiary

Owensboro KY 42301

Emeryville CA 94608-2916

Emeryville CA 94608-2916

Chiron Corporation 4560 Horton St.

Astellas Pharma US, Inc. Three Parkway North Deerfield IL 60015-2548

Merck & Co., Inc. 126 East Lincoln Ave. Rahway NJ 07065-0900

Richard J. Wenstrup, M.D.

Cinergen, LLC 146 Medinah Drive Blue Bell PA 19422-3212

Cinergen, LLC 146 Medinah Drive Blue Bell PA 19422-3212

Genzyme Corporation One Kendall Square

Atlantic Healthcare Limited Maple House Halsted, Essex CO9 4BB UNITED KINGDOM

Ligand Pharmaceuticals, Inc. 10275 Science Center Dr.

Alwyn Company, Inc. 2301 Highway 60 East Lake Crystal MN 56055

Pervasis Therapeutics, Inc. One Kendall Square First Floor

Post Office Box 1000

Angioblast Systems, Inc. 275 Madison Avenue New York NY 10016

Neurotech USA, Inc. 6 Blackstone Valley Place Lincoln RI 02865

Emeryville CA 94608-2916

Division of Human Genetics

Children's Hospital Research Foundation

Cincinnati OH 45229-3039

Cambridge MA 02139-1562

San Diego CA 92121-1117

Cambridge MA 02139

Bayer Healthcare Pharmaceuticals, Inc.

50 Division Street, Suite 503

Montville NJ 07045-1000

Applied Immunotherapeutics, LLC

14132 E. Firestone Boulevard

Santa Fe Springs CA 90670

MolMed S.p.A. Via Olgettina 58 Milan 20132 ITALY

Burroughs Wellcome Company 3030 Cornwallis Road P.O. Box 12700

Burroughs Wellcome Company 3030 Cornwallis Road P.O. Box 12700

Burroughs Wellcome Company 3030 Cornwallis Road

Bio Products Laboratory WD6 3BX UNITED KINGDOM

Bio Products Laboratory Dagger Lane Elstree, Hertfordshire UNITED KINGDOM

Chiron Corporation 4560 Horton Street

Kamada, Ltd. 7 Sapir Street Ness Ziona ISRAEL

Kamada Ltd. Kiryat Weizmann ISRAEL

Kamada Ltd. Kiryat Weizmann ISRAEL

CSL Behring LLC 1020 First Avenue King of Prussia PA 19406

CSL Behring L.L.C. 1020 First Ave. PO Box 61501

Desnick, Robert J. M.D.

David Calhoun, Ph.D. Department of Chemistry

Research Triangle Park NC 27709

Research Triangle Park NC 27709

Research Triangle Pk NC 27709

Dagger Lane, Elstree, Hertfordshire

Emeryville CA 94608-2916

King of Prussia PA 19406-0901

The Mount Sinai School Of Medicine

Fifth Avenue at 100th Street, Box 1203

New York NY 10029

Convent Avenue & 138th Street

New York NY 10031

700 Main Street Cambridge MA 02139

Building 31, Room 9N-222

39 Old Ridgebury Road Suite 11

Schwarz Pharma, Inc. P.O. Box 2038 Milwaukee WI 53201

Daniel F. Hanley, MD Johns Hopkins University

Sanofi-Aventis US, Inc. 55 Corporate Drive Bridgewater NJ 08807

Ablynx NV Technologiepark 4 B-9052 Zwijnaarde BELGIUM

Amgen Inc. One Amgen Center Drive

Medimmune Oncology, Inc. One MedImmune Way Gaithersburg MD 20878

Medimmune LLC One MedImmune Way Gaithersburg MD 20878

Medimmune, LLC One MedImmune Way Gaithersburg MD 20878

Medimmune LLC One MedImmune Way Gaithersburg MD 20878

Transave, Inc. 11 Deer Park Drive

5 Moore Drive PO Box 13398

Eastern Virginia Medical School

DUSA Pharmaceuticals, Inc. 25 Upton Drive Wilmington MA 01887

Shire Human Genetic Therapies, Inc.

National Institute of Diabetes, and Digestive and Kidney Diseases

National Institutes of Health, 31 Center Drive MSC

Bethesda MD 20892-2560

Penwest Pharmaceuticals Company

Danbury CT 06810

600 N. Wolfe St., Jefferson 1-109

Baltimore MD 21287

Thousand Oaks CA 91320-1799

Monmouth Junction NJ 08852-1923

Glaxo Wellcome Research and Development

Research Triangle Park NC 27709

Department of Ophthalomology

880 Kempsville Road, Suite 2500

Norfolk VA 23502-3990

Syncom Pharmaceuticals, Inc. 66 Hanover Road Florham Park NJ 07932

580 California Street San Francisco CA 94104

Kanyok, Thomas P. Pharm.D.

Kanyok, Thomas P. Pharm.D.

Kanyok, Thomas P. Pharm.D.

Academic Pharmaceuticals, Inc. Suite G3

Pipex Pharmaceuticals, Inc. 3930 Varsity Drive Ann Arbor MI 48108

Pipex Pharmaceuticals, Inc. 3930 Varsity Drive Ann Arbor MI 48108

Xanthus Pharmaceuticals, Inc. 300 Technology Square Cambridge MA 02139

150 Industrial Road San Carlos CA 94070

The Liposome Company, Inc. One Research Way Princeton NJ 08540

The Liposome Company, Inc. One Research Way Princeton NJ 08540

The Liposome Company, Inc. One Research Way Princeton NJ 08540

The Liposome Company, Inc. One Research Way Princeton NJ 08540

The Liposome Company, Inc. One Research Way Princeton NJ 08540

The Institute for One World Health

University of Illinois at Chicago College of Pharm

833 South Wood Street (m/c886) Rm. 176

Chicago IL 60612

University Of Illinois At Chicago College of Pharm

833 South Wood Street (m/c886) Rm. 176

Chicago IL 60612 University of Illinois at

Chicago College of Pharm

833 South Wood Street (m/c886) Rm. 176

Chicago IL 60612

21 N. Skokie Valley Highway

Lake Bluff IL 60044

Novartis Pharmaceuticals Corporation

Celgene Corporation 9900 W. 109th Street Suite 300

Warner-Lambert Company 2800 Plymouth Road

Akorn, Inc. 2500 Millbrook Drive Buffalo Grove IL 60089

Roberts Pharmaceutical Corp. Meridian Center II 4 Industrial Way West

Roberts Pharmaceutical Corp. Meridian Center II 4 Industrial Way West

Genzyme Corporation One Kendall Square Cambridge MA 02139

Scios, Inc. 2450 Bayshore Parkway Mountain View CA 94043

Scios, Inc. 2450 Bayshore Parkway Mountain View CA 94043

Xytis, Inc. Suite 1200

Knoll Pharmaceutical Company Mt. Olive NJ 07828

Newport Beach CA 92660

Maret Pharmaceuticals 4041 MacArthur Blvd. Suite 375

Cangene Corporation 155 Innovation Drive R3T 5Y3 CANADA

One Health Plaza East Hanover NJ 07936

Xoma Corporation 2910 Seventh Street Berkeley CA 94710

Overland Park KS 66210

Parke-Davis Pharmaceutical Research Division

Ann Arbor MI 48106

Eatontown NJ 07724-2274

Eatontown NJ 07724-2274

400 South El Camino Real

San Mateo CA 94402-1703

3000 Continental Dr., North

Maret Pharmaceutical Corporation

4041 MacArthur Boulevard, Suite 375

Newport Beach CA 92660

Novartis Pharmaceuticals Corporation

Xoma Corporation 2910 Seventh Street Berkeley CA 94710

AEterna Zentaris, Inc. Dr. Claude Hariton CANADA

Biogen IDEC, Inc. 5200 Research Place

Xencor, Inc. 111 W. Lemon Avenue Monrovia CA 91016

Seattle Genetics, Inc. Bothell WA 98021

Baxter Healthcare Corporation 1620 Waukegan Road Mcgaw Park IL 60085

957 Buckingham Avenue Berkshire SL1 4NL UNITED KINGDOM

Biomedical Research Institute 345 North Smith Avenue St. Paul MN 55102

Biomedical Research Institute 345 North Smith Avenue St. Paul MN 55102

Biomedical Research Institute 345 North Smith Avenue St. Paul MN 55102

Biomedical Research Institute 345 North Smith Avenue St. Paul MN 55102

50 Pequot Avenue New London CT 06320

Children's Hospital 700 Children's Drive Columbus OH 43205

Bayer HealthCare LLC 555 Whiteplains Road Tarrytown NY 10591-5124

Advanced Biotherapy, Inc. Suite 510

Chief Medical Officer, VP, Cli

Quebec G1P 4P5, Canada

San Diego CA 92122

21823 30th Drive Southeast

Xenova Biomedix Limited CELTIC PHARMA

Pfizer Global Research & Development

6355 Topanga Canyon Blvd.

Woodland Hills CA 91367

Xoma Corporation 2910 Seventh Street Berkeley CA 94710

Xoma Corporation 2910 Seventh Street Berkeley CA 94710

9432 Old Katy Road Houston TX 77055

Upsher-Smith Laboratories, Inc 4905 23rd Avenue North Minneapolis MN 55447

Lorus Therapeutics, Inc. 2 Meridan Road M9W 4Z7 CANADA

Lorus Therapeutics, Inc 2 Meridan Road M9W427 CANADA

Genzyme Corporation Drug & Biomaterial R&D 153 Second Avenue

CoDa Therapeutics, Inc. San Diego CA 92121

Tolera Therapeutics, Inc. 4717 Campus Drive #800 Kalamazoo MI 49008

Xoma Corporation 2910 Seventh Street Berkeley CA 94710

Bradmer Pharmaceuticals, Inc. Suite 3000

CSL Behring 1020 First Ave. PO Box 61501

American National Red Cross Bethesda MD 20814

Genzyme Corporation 500 Kendall Street Cambridge MA 02142

Burzynski Research Institute, Inc.

Waltham MA 02451

10505 Sorrento Valley Road

9900 Corporate Campus Drive

Louisville KY 40223

King of Prussia PA 19406-0901

9312 Old Georgetown Road

Applied Medical Research 1600 Hayes Street Nashville TN 37203

920 Winter Street Waltham MA 02451

Rare Disease Therapeutics, Inc. 2550 Meridian Blvd Franklin TN 37067

Ophidian Pharmaceuticals, Inc. Madison WI 53711

Archemix Corporation 300 Third Street Cambridge MA 02142

Ariad Pharmaceuticals, Inc. 26 Landsdowne St.

211 Bailey Rd.

Scherer DDS Frankland Road Swindon SN5 8RU Wiltshire UNITED KINGDOM

Pentech Pharmaceuticals, Inc. 1110 Lake Cook Rd. Suite 257

50 Undine Road Newton MA 02135

Immtech Pharmaceuticals, Inc. 150 Fairway Drive Vernon Hills IL 60061

Immunomedics, Inc. 300 American Road Morris Plains NJ 07950

MolMed S.p.A. Via Olgettina 58 Milan ITALY

Vertex Pharmaceuticals Inc. 130 Waverly Street

Fresenius Biotech North America

5445 East Cheryl Parkway

Cambridge MA 02139-4234

Wyeth-Lederle Vaccines and Pediatrics

West Henrietta NY 14586-9728

Buffalo Grove IL 60089

NeuroHealing Pharmaceuticals, Inc.

Cambridge MA 02139-4242

Perrine, Susan P., M.D. Boston University Cancer Research Center

CytRx Corporation 3030 Bunker Hill Street Suite 105

Floyd R. Sallee, M.D., Ph.D.

Cephalon, Inc. 41 Moores Road Frazer PA 19355

Cephalon Inc 41 Moores Road P. O. Box 4011

Cephalon, Inc. 41 Moores Road Frazer PA 19355

Cephalon, Inc. 41 Moores Road Frazer PA 19355

Cephalon, Inc. 41 Moores Road Frazer PA 19355

Cephalon, Inc. 41 Moores Road Frazer PA 19355

Cephalon, Inc. 41 Moores Road P.O. Box 4011

Novartis Pharmaceuticals Bldg 405/4051 One Health Plaza

World Health Organization Via Appia , Geneva 27 SWITZERLAND

622 Neiman Street

Boston MA 02118

San Diego CA 92109

University of Cincinnati School of Medicine/

P. O. Box 670669 231 Albert Sabin Way

Cincinnati OH 45267-0559

Frazer PA 19355

Frazer PA 19355 East Hanover NJ 07936-1080

Special Programme for Research and Training in Tro

US Army Medical Materiel Development Activity

Office of the Surgeon General

Ft. Detrick MD 21702-9240

700 Main Street Cambridge MA 02139

NPDC-AS101, Inc. 783 Jersey Avenue New Brunswick NJ 08901

McGuff Pharmaceuticals Inc. 2921 W. McArthur Blvd.

Eli Lilly & Company Lilly Corporate Center Indianapolis IN 46285

GlaxoSmithKline, Inc. 5 Moore Drive PO Box 13398

GlaxoSmithKline, Inc. 5 Moore Drive PO Box 13398

TVAX Biomedical, LLC 8060 Reeder Street Lenexa KS 66214-1554

Dendreon Corporation 3005 First Avenue Seattle WA 98121

Cellular Bioengineering, Inc. 1946 Young Street Honolulu HI 96826

Northwest Biotherapeutics, Inc. 22322 20th Avenue SE Suite 150

Avax Technologies, Inc. Building 9, Suite 200

Proneuron Biotechnologies, Inc. 2029 Century Park East Sixth Floor

Kiadis Pharma Canada, Inc. 2525 Marie Curie CANADA

RhinoCyte, Inc. 201 E. Jefferson Street Louisville KY 40202-1246

RhinoCyte, Inc. 201 E. Jefferson Street Louisville KY 40202-1246

Shire Human Genetic Therapies, Inc.

Santa Ana CA 92704-6929

Research Triangle Park NC 27709 Research Triangle Park NC 27709-3398

Bothell WA 98021

9200 Indian Creek Parkway

Overland Park KS 66210

Los Angeles CA 90067

Montreal (Quebec) H4S 2E1

TissueTech, Inc. 7000 SW 97th Avenue Miami FL 33173

Antigenics, Inc. 3 Forbes Rd. Lexington MA 02421

Antigenics, Inc. 3 Forbes Rd. l MA 02421

Cytogen Corporation 600 College Road East CN 5308

Biogen Idec MA, Inc. 14 Cambridge Center Cambridge MA 02142

Pfizer, Inc. San Diego CA 92121

Oral Solutions, Inc. New York NY 10019

2025 First Ave. Suite 800

OncoVac Corporation P. O. Box 970

A. L. Laboratories, Inc. One Executive Drive P.O. Box 1399

Infusaid, Inc. Norwood MA 02062

Medtronic, Inc. 800 53rd Avenue N.E. P.O. 1250

Medtronic Neurological

Reata Pharmaceuticals, Inc. 2801 Gateway Drive Irving TX 75063

Princeton NJ 08540-5308

10646 Science Center Drive

787 Seventh Ave., 48th Floor

Gilead Sciences (formerly Corus Pharma)

Seattle WA 98121

Pacific Palisades CA 90272

Fort Lee NJ 07024

1400 Providence Highway

Minneapolis MN 55440-9087

710 Medtronic Parkway NE

Minneapolis MN 55432-5604

Eurand Pharmaceuticals, Inc. 790 Township Line Road Yardley PA 19067

DOR BioPharma, Inc. 29 Emmons Drive Suite C-10

DOR BioPharma, Inc. 29 Emmons Drive Suite C-10

DOR BioPharma, Inc. 29 Emmons Drive Suite C-10

Bristol-Myers Squibb Company P. O. Box 4000 Princeton NJ 08543-4000

Fallien Cosmeceuticals Ltd. 677 W. Dekalb Pike King of Prussia PA 19406

Angelini Pharmaceuticals, Inc. 70 Grand Avenue River Edge NJ 07661

AllerQuest LLC 836 Farmington Avenue Suite 207

Ross Laboratories 625 Cleveland Avenue Columbus OH 43215

LungRx, Inc. 1104 Spring Street Silver Spring MD 20910

Dovetail Technologies, Inc. College Park MD 20742

Dovetail Technologies, Inc. College Park MD 20742

Floyd R. Sallee, M.D., Ph.D. ML 0559

Medco Research, Inc. 8455 Beverly Blvd. Suite 308

Medco Research, Inc. 8455 Beverly Blvd. Suite 308

Princeton NJ 08540

Princeton NJ 08540

Princeton NJ 08540

West Hanford CT 06119-1551

Bldg. 337, Paint Branch Drive

Bldg. 337, Paint Branch Drive

University of Cincinnati School of Medicine

Cincinnati OH 45267-0559

Los Angeles CA 90048

Los Angeles CA 90048

1440 Davey Road Woodridge IL 60517

Genentech, Inc. 1 DNA Way

Genentech, Inc. 1 DNA Way

Genentech, Inc. 1 DNA Way, MS #242

Genentech, Inc. 1 DNA Way

Alimentary Health Limited Cork IRELAND

Alimentary Health Limited Guardwell, Kinsale County Cork IRELAND

Angelini Pharmaceuticals, Inc. 70 Grand Avenue Suite 109

Excorp Medical, Inc. Suite 235 7200 Hudson Blvd.

TissueTech, Inc. 7000 SW 97th Avenue Miami FL 33173

ICAgen Inc. Ion Channel Advances PO Box 14487

MedImmune, LLC One MedImmune Way Gaithersburg MD 20878

MedImmune, LLC One MedImmune Way Gaithersburg MD 20878

MedImmune, LLC One MedImmune Way Gaithersburg MD 20878

MedImmune, LLC One MedImmune Way Gaithersburg MD 20878

Advanced Life Sciences, Inc. (ALS)

South San Francisco CA 94080-4990

South San Francisco CA 94080-4990

South San Francisco CA 94080-4990

South San Francisco CA 94080-4990

Cork Airport Business Park, Building 2800

River Edge NJ 07661

Oakdale MN 55128

Durham NC 27709

MedImmune, LLC One MedImmune Way Gaithersburg MD 20878

The Medicines Company 8 Sylvan Way Parsippany NJ 07054

Genetronics, Inc.

Bristol-Myers Squibb 5 Research Parkway Wallingford CT 06492

Actelion Pharmaceuticals Ltd Gewerbestrasse 16 CH-4123 SWITZERLAND

Wyeth Pharmaceuticals, Inc. 87 Cambridge Park Drive Cambridge MA 02140

Ipsen Limited 1 Bath Rd., Maidenhead Berkshire SL6 4UH UNITED KINGDOM

Ipsen Biopharm Limited 1 Bath Road Maidenhead UNITED KINGDOM

Porton International, Inc. Washington DC 20005

Allergan, Inc. 2525 Dupont Drive P.O. Box 19534

Quincy MA 02169

Ipsen Limited 27 Maple Street Milford MA 01757-3650

27 Maple Street Milford MA 01757-3650

Hastings, Donald DVM Bismarck ND 58501

11199 Sorrento Valley Rd.

San Diego CA 92121-1334

Berkshire, SL6 4UH

1155 15th Street, N.W., #315

Irvine CA 92623-9534

Botulinum Toxin Research Associates, Inc.

1261 Furnace Brook Parkway

Ipsen Limited (name changed from Porton International Inc)

1030 North Parkview Drive

GalaGen, Inc. Arden Hills MN 55126

Biomune Systems, Inc. Salt Lake City UT 84108

Mount Sinai Medical Center New York NY 10029

Allergan, Inc. 2525 Dupont Dr. P.O. Box 19534

UCB Pharma, Inc. 1950 Lake Park Drive Smyra GA 30080

SciClone Pharmaceuticals, Inc. 901 Mariner's Island Blvd. San Mateo CA 94404

Ridgefield CT 06877-0368

NeoPharm, Inc. Lake Forest IL 60045

GPC Biotech, Inc. 610 Lincoln Street Waltham MA 02451

Digestive Care, Inc. 1120 Win Drive Bethlehem PA 18017

Alpha Pharmaceuticals, LLC Piscataway NJ 08854

Sparta Pharmaceuticals, Inc. 111 Rock Road Horsham PA 19044-2310

SuperGen, Inc. 4140 Dublin Boulevard Dublin CA 94568

SuperGen, Inc. 4140 Dublin Blvd Suite 200

SuperGen, Inc. San Ramon CA 94583

4001 Lexington Avenue North

540 Arapeen Drive, Suite 202

One Gustave L. Levy Place

Irvine CA 92623-9534

Boehringer Ingelheim Pharmaceuticals, Inc.

900 Ridgebury Road, Box 368

225 East Deerpath, Suite 250

One New England Avenue

Dublin CA 94568

Two Annabel Lane, Suite 220

Los Angeles CA 90027

4650 Sunset Blvd, MS 55

Shire Laboratories Inc. 1550 East Gude Drive Rockville MD 20850

Shire Laboratories Inc. 1550 East Gude Drive Rockville MD 20850

Burroughs Wellcome Company 3030 Cornwallis Road P.O. Box 12700

Alpha Therapeutic Corporation 5555 Valley Boulevard Los Angeles CA 90032

CSL Behring L.L.C. 1020 First Ave. PO Box 61501

Baxter Healthcare Corp. One Baxter Way

Baxter Healthcare Corp. 550 North Brand Blvd.

Seattle Genetics, Inc. Bothell WA 98021

Sandoz Pharmaceuticals Corp. 59 Route 10 East Hanover NJ 07936

Pharmedic Company Lake Forest IL 60045

R & D Laboratories, Inc. 4204 Glencoe Avenue

Calgonate Corp. 3310 South Ocean Blvd Unit 132

USC-CHLA Institute for Pediatric Clinical Research

Childrens Hospital of Los Angeles MS 55

USC-CHLA Institute for Pediatric Clinical Research

Childrens Hospital of Los Angeles

Los Angeles CA 90027

Research Triangle Pk NC 27709

King of Prussia PA 19406-0901

Westlake Village CA 91362

Hyland Division (Baxter Hyland)

Glendale CA 91203

21823 30th Drive Southeast

28101 Ballard Road, Suite F

Marina Del Rey CA 90292

Highland Beach FL 33487

Calgonate Corporation 3310 South Ocean Blvd Unit 132

Paddock Laboratories, Inc. Minneapolis MN 55427

Pneuma Pharmaceuticals, Inc. 1576 Sweet Home Road Suite 114

One Health Plaza

TheraQuest Biosciences, LLC 146 Medinah Drive Blue Bell PA 19422-3212

Anesiva, Inc. 650 Gateway Blvd

NeurogesX, Inc. 981F Industrial Road San Carlos CA 94070

NeurogesX, Inc. 981F Industrial Road

Orphan Europe Immeuble "Le Guillaumet" Cedex 70 FRANCE

INO Therapeutics 6 Route 173 Clinton NJ 08809

Glaxo Wellcome Inc. 5 Moore Drive

Digna Biotech, S.L. Pamplona (Navarra) SPAIN

Proteolix, Inc. 333 Allerton Avenue

Direct Therapeutics, Inc. 460 Seaport Court Suite 220

Intramed Corporation 102 Tremont Way Augusta GA 30907

Highland Beach FL 33487

3940 Quebec Avenue North

Amherst NY 14228

Novartis Pharmaceuticals Corporation

East Hanover NJ 07936-1080

South San Francisco CA 94080

San Carlos Business Park

San Carols CA 94070-4117

Research Triangle Park NC 27709

Avenids Carlos III de Noble

South San Francisco CA 94080

Redwood CA 94063

99 Hayden Avenue Lexington MA 02420-9192

SmithKline Beecham

Xoma Corporation 2910 Seventh Street Berkeley CA 94710

Celltech Chiroscience Limited 216 Bath Road Slough SL1 4EN UNITED KINGDOM

MS 6025-B4179 50 Pequot Avenue

Mass General Hospital

P.O. Box 376 Ann Arbor MI 48106

Eleos, Inc. 3033 Campus Drive Plymouth MN 55441

Eleos, Inc. 7824 Jackson Street Omaha NE 68114

Eleos, Inc. Omaha NE 68154

Istituto Bioclon S.A. de C.V. Tlalpan MEXICO

Advanced LIfe Sciences, Inc. 1440 Davey Road Woodridge IL 60517

ImClone Systems Incorporated 33 ImClone Drive Branchburg NJ 08876

Dr. Falk Pharma GmbH Leinenweberstrasse 5 9041 Freiburg, GERMANY GERMANY

9841 Washingtonian Blvd Suite 500

Fresenius Biotech North America, Inc.

Route 23 & Woodmont Ave., P.O. Box 1510 King Of Prussia PA 19406

Pfizer Global Research & Development

New London CT 06320

Merit E. Cudkowicz, MD, MSc

Building 149 13th Street, Room 2274

Charlestown MA 02129

Aastrom Biosciences Incorporated

One Valmont Plaza - Corporate Headquarters

Calzada de Tlalpan No. 4687

Baker Cummins Pharmaceuticals, Inc.

Sigma-Tau Pharmaceuticals, Inc.

Gaithersburg MD 20878

Wilex Biotechnology GmbH Grillparzerstrasse 10B 81675 Munich GERMANY

Centocor, Inc. Malvern PA 19355-1307

Centocor, Inc. Malvern PA 19355-1307

Thallion Pharmaceuticals, Inc. 7150 Alexander-Fleming CANADA

Morphotek, Inc. 210 Welsh Pool Road Exton PA 19341

Centocor, Inc. Malvern PA 19355

CSl Limited 45 Poplar Road AUSTRALIA

Biosynexus, Inc. 9298 Gaither Road Rockville MD 20877

Procter & Gamble Company

TransMolecular, Inc. 840 Memorial Drive Cambridge MA 02139

TransMolecular, Inc. 840 Memorial Drive Cambridge MA 02139

Trophos SA 13288 Marseille cedex FRANCE

3333 Burnet Ave. MLC 5006

Bioniche Pharma USA LLC 272 E. Deerpath Road Suite 304

200 Great Valley Parkway

200 Great Valley Parkway

Montreal, Quebec, H4S 2C8

244 Great Valley Parkway

Sharon Wood Technical Center

11370 Reed Hartman Highway

Cincinnati OH 45241

Parc scientifique de Luminy

Cincinnati Children's Hospital Medical Center

Cincinnati OH 45229-3039

Alan L. Buchman, M.D., M.S.P.H.

Feinberg School of Medicine, Dept. of Gastroentero

676 N. St. Clair St., Suite 1400

Chicago IL 60611

Lake Forest IL 60045

Curis, Inc. 61 Moulton Street Cambridge MA 02138

8500 Hidden River Pkwy. Tampa FL 33637

Gilead Sciences, Inc. 77575 W. 103rd Avenue Suite 102

EMD Serono, Inc. One Technology Place Rockland MA 02370

Regeneron Pharmaceuticals Inc Tarrytown NY 10591

Syntex-Synergen Neuroscience 3200 Walnut Street Boulder CO 80301

Syntex-Synergen Neuroscience 3200 Walnut Street Boulder CO 80301

Transave, Inc. 11 Deer Park Drive

Matrix Pharmaceutical, Inc. 34700 Campus Drive Fremont CA 94555-3612

Matrix Pharmaceutical, Inc. 34700 Campus Drive Fremont CA 94555-3612

Winston Laboratories, Inc. Vernon Hills IL 60061

920 US Highway 202

P. O. Box 300

920 Route 202 PO Box 300

Bausch & Lomb Pharmaceuticals, Inc.

Westminster CO 80021

777 Old Saw Mill River Road

Monmouth Junction NJ 08852-1923

100 Fairway Drive, Suite 134

Ortho Biotech Oncology Research & Development

Johnson & Johnson Pharmaceutical Research & Dev.,

Raritan NJ 08869

Ortho Biotech Oncology Research & Development

Unit of J & J Pharmaceutical Research & Developmen

Raritan NJ 08869

Johnson & Johnson Pharmaceutical R & D, LLC

Raritan NJ 08869-0602

Ortho Biotech Oncology Research & Development

Unit of J & J Pharmaceutical Research & Dev., LLC

920 Route 202 South, P.O. Box 300

Raritan NJ 08869-0602

Actelion Pharmaceuticals Ltd. Gewerbestrasse 16 SWITZERLAND

Pfizer Inc. 235 East 42nd Street 150-3-46

Pharmacia & Upjohn 7000 Portage Road Unit 0633-298-113

3423 Hill Canyon Avenue

Lundbeck, Inc. Four Parkway North Deerfield IL 60015

4545 Horizon Hill Blvd.

Hoffmann-La Roche, Inc. 340 Kingsland Street Nutley NJ 07110

Jazz Pharmaceuticals, Inc. 3180 Porter Drive Palo Alto CA 94304

Auxilium Pharmaceuticals, Inc. Malvern PA 19335

Effective Pharmaceuticals, Inc. 150 Broadway Suite 1800

EnVivo Pharmaceuticals, Inc. 480 Arsenal Street Watertown MA 02472

Brugnara, Carlo M.D. The Children's Hospital

Genta, Inc. Two Connell Drive

New York NY 10017

Kalamazoo MI 49001-0199

Autoimmunity Research Foundation Thousand Oaks CA 91360

Genzyme Corp (Ilex Products, Inc.)

San Antonio TX 78229-2263

40 Valley Stream Parkway

New York NY 10038

300 Longwood Avenue, Bader 760

Boston MA 02115

Berkeley Heights NJ 07922

Novo Nordisk, Inc. 100 College Road West Princeton NJ 08540

Novo Nordisk, Inc. 100 College Road West Princeton NJ 08540

Novo Nordisk, Inc. 100 College Road West Princeton NJ 08540

4520 East-West Highway Third Floor

Allermed Labortories, Inc. 7203 Convoy Court San Diego CA 92111

Integrative Therapeutics, Inc. 825 Challenger Drive Green Bay WI 54311

AR Scientific, Inc. 1100 Orthodox Street Philadelphia PA 19124

AR Scientific, Inc. 1100 Orthodox Street Philadelphia PA 19124

Pharmacontrol Corporation

Auxilium Pharmaceuticals, Inc. Malvern PA 19355

OXiGENE, Inc. 230 Third Avenue Waltham MA 02451

OXiGENE, Inc 321 Arsenal Street Watertown MA 02472

Xenova Biomedix Limited 957 Budkingham Avenue Slough UNITED KINGDOM

Jarrow Formulas, Inc. 1824 S. Robertson Blvd.

Cognetix, Inc. 421 Wakara Way Salt Lake City UT 84108

Sucampo Pharma Americas, Inc.

Bethesda MD 20814

661 Palisade Ave., P.O. Box 931

Englewood Cliffs NJ 07632

40 Valley Stream Parkway

Los Angeles CA 90035-4317

OncoVista, Inc. 14785 Omicron Drive San Antonio TX 78245

1387 Marina Way South Richmond CA 94804

Drossapharm LTD 4002 Basel SWITZERLAND

Viralytics Limited P. O. Box 1045 Pymble Business Centre AUSTRALIA

Avicena Group, Inc. 228 Hamilton Avenue Palo Alto CA 94301

Avicena Group, Inc. 580 California St. Suite 1600

Department 0322

ImmuCell Corporation 56 Evergreen Drive Portland ME 04103

Duke University Medical Center Erwin Road

Cytel Corporation 3525 John Hopkins Court San Diego CA 92121

Cytel Corporation 3525 John Hopkins Court San Diego CA 92121

Cytel Corporation 3525 John Hopkins Court San Diego CA 92121

Lux Biosciences, Inc. Plaza 10, 14th Floor

Maas Biolab,LLC 1155 University Blvd., SE

Neurobiological Technologies, Inc.

San Francisco CA 94104

University of California, San Diego

Aroian Laboratory, Div. of Biological Sciences

LaJolla CA 92093-0322

Division of Pediatric Allergy & Immunology

Durham NC 27710

Hoarborside Financial Center

Jersey City NJ 07302

Tecnology Ventures Corporation Technopolis

Albuquerque NM 87106

Sigmoid Pharma Limited Dublin City University IRELAND

Sigmoid Pharma Limited Dublin City University IRELAND

APT Pharmaceuticals, Inc. 700 Airport Blvd. Suite 350

APT Pharmaceuticals, Inc. 700 Airport Blvd. Suite 350

Allergan, Inc. 2525 Dupont Drive P.O. Box 19534

Allergan, Inc. 2525 Dupont Drive P.O. Box 19534

NOVAGALI Pharma SA Batiment Genavenir IV F-91058-Evry cedex FRANCE

Novagali Pharma S.A. 1 rue Pierre Fontaine 91058 Evry cedex FRANCE

Novagali Pharma S.A. 1 rue Pierre Fontaine 91058 Evry cedex FRANCE

Lux Biosciences, Inc. Plaza 10, 14th Floor

RTP Pharma Corporation 4364 South Alston Avenue

University Of Georgia

Berlex Laboratories, Inc. 300 Fairfield Road Wayne NJ 07470

Adherex Technologies, Inc. 4620 Creekstone Drive Durham NC 27703

Burlingame CA 94010

Burlingame CA 94010

Irvine CA 92623-9534

Irvine CA 92623-9534

Harborside Financial Center

Jersey City NJ 07302

200 Westpark Corporate Center

Durham NC 27713-2280

College Of Veterinary Medicine

Department of Small Animal Medicine

Athens GA 30602

9 Commercial Blvd. Novato CA 94949

Bennu Pharmaceuticals 9 Commerical Blvd Novato CA 94949

Thoene, Jess G., M.D. 300 NIB, 1192 SE

9841 Washingtonian Blvd Suite 500

Genzyme Corporation One Mountain Rd. P.O. Box 9322

GenVec, Inc. 12111 Parklawn Drive Rockville MD 20852

Genzyme Corporation One Mountain Road P.O. Box 9322

Genetic Therapy, Inc. 938 Clopper Road Gaithersburg MD 20878

Bruce Frankel, MD

Celator Pharmaceuticals, Inc. 303 B College Road East Princeton NJ 08540

Vical Inc. San Diego CA 92121

Vical Incorporated San Diego CA 92121

Bayer Corporation 400 Morgan Lane

Norwich Eaton Pharmaceuticals P.O. Box 191 Norwich NY 13815

Bennu Pharmaceuticals, Inc. (dual EMEA)

University of Michigan Medical School

Ann Arbor MI 48109-0408

Sigma-Tau Pharmaceuticals, Inc.

Gaithersburg MD 20878

Framingham MA 01701-9322

Framingham MA 01701-9322

Medical University of South Carolina

96 Jonathan Lucas Street, Suite 428 CSB

Charleston SC 29425

10390 Pacific Center Court

10390 Pacific Center Court

Pharmaceutical Division, Biological Products

New Haven CT 06516

37 Cleveland Lane P.O. Box 5290

37 Cleveland Lane P.O. Box 5290

37 Cleveland Lane P.O. Box 5290

Diatos USA, LLC 15310 Amberly Drive Tampa FL 33647

Helsinn Healthcare SA Lugano SWITZERLAND

MediWound, Ltd. 3, Azrieli Center Tel-Aviv 67023 ISRAEL

Eisai Medical Research, Inc. 6611 Tributary Street Baltimore MD 21224-6515

Eisai Medical Research, Inc. 6611 Tributary Street Baltimore MD 21224-6515

Eisai Medical Research, Inc. 6611 Tributary Street Suite 200

ApoPharma, Inc. 200 Barmac Drive CANADA

ApoPharma, Inc. A Division of Apotex Research Inc. Toronto, Canada M9L 1T9 CANADA

Biomedical Frontiers, Inc. 1095 10th Avenue, SE Minneapolis MN 55414

Gentium SpA Piazza XX Settembre, 2 ITALY

Gentium SpA Piazza XX Settembre, 2 22079 Villa Guardia (CO) ITALY

Jacobus Pharmaceutical Company, Inc.

Princeton NJ 08540

Jacobus Pharmaceutical Company

Princeton NJ 08540

Jacobus Pharmaceutical Company

Princeton NJ 08540

Via Pian Scairolo, 6912 Pazzallo

Baltimore MD 21224-6515

Crinos International Via Belvedere 1 Villa Guardia, Italy 22079

Genelabs Technologies, Inc. 505 Penobscot Drive Redwood City CA 94063

Paladin Labs, Inc. Montreal CANADA

Pharmadigm, Inc. 2401 Foothill Drive

Pharmadigm, Inc. 2401 Foothill Drive

Roberts Pharmaceutical Corp. Meridian Center II Four Industrial Way West

Peptimmune, Inc. 64 Sidney Street

Allergan 2525 Dupont Drive P. O. Box 19534

EyeGate Phardmaceuticals, Inc. 100 Beaver Street Waltham MA 02453

Pharmos Corporation 99 Wood Avenue Suite 311

BCY LifeSciences Inc. 160 Eglinton Ave. East Suite 600 CANADA

Holles Laboratories, Inc. 30 Forest Notch Cohasset MA 02025

Biomedical Frontiers, Inc. 1095 10th Avenue S.E. Minneapolis MN 55414

Kennedy & Hoidal, M.D.'s

6111 Royalmount Avenue, Suite 102

Quebec H4P 2T4

Salt Lake City UT 84109-1405

Salt Lake City UT 84109-1405

Eatontown NJ 07724-2274

Cambridge MA 02139-4170

Irvine CA 92623-9534

Iselin NJ 08830

Toronto, Ontario M4P 3B

University Of Utah Medical Center

50 North Medical Drive, Room 4R240

Salt Lake City UT 84132

Osaka 541 JAPAN

Luitpold Pharmaceuticals, Inc.. 800 Adams Avenue

Luitpold Pharmaceuticals, Inc. 800 Adams Avenue 1st Floor

Luitpold Pharmaceuticals, Inc.. 800 Adams Avenue

Baxter Healthcare Corporation 1620 Waukegan Road McGaw Park IL 60085

Warner-Lambert Company Ann Arbor MI 48106

Bristol-Myers Squibb Evansville IN 47721

Connaught Laboratories Route 611, P.O. Box 187 Swiftwater PA 18370

CIS-US 10 DeAngelo Drive Bedford MA 01730

Genzyme Corporation 153 Second Avenue Waltham MA 02451

Allertein Therapeutics, LLC 640 Sasco Hill Road Fairfield CT 06824

Sirion Therapeutics, Inc. Tampa FL 33619

Bette S. Pollard, LLC 11008 Lamplighter Lane Potomac MD 20854

PrimeCyte, Inc. 130 Fifth Ave., N. Seattle WA 98109-4933

PrimeCyte, Inc. 130 Fifth Ave., N. Seattle WA 98109-4933

Ueno Fine Chemicals Industry, Ltd.

2-31 Koraibashi, Higashi-ku

Clinical Research & Development

Valley Forge PA 19403

Valley Forge PA 19403

Clinical Research and Development

Valley Forge PA 19403

2800 Plymouth Rd., P.O. Box 1047

2400 West Lloyd Expressway

9314 E. Broadway Avenue

Boehringer Mannheim Corp. 1301 Piccard Drive Rockville MD 20850

Sigma-Tau Research, Inc. 9841 Washingtonian Blvd Suite 502

Besins Internaitonal, US Inc. 610 Herndon Parkway Suite 750

Abela Pharmaceuticals, Inc. 21581 Midcrest Drive Lake Forest CA 92630

Abela Pharmaceuticals, Inc. 21581 Midcrest Drive Lake Forest CA 92630

Research Industries Corp.

Cancer Technologies, Inc. 7301 East 22nd Street Suite 10E

Cancer Technologies, Inc. 7301 East 22nd Street Suite 10E

Forum Products, Inc. 33 Flying Point Road Southampton NY 11968

Lloyd E. King, Jr. 1900 Patterson Street Suite 104

ImmunoTherapeutics, Inc. 3505 Riverview Circle Moorhead MN 56560

29949 S.R. 54 West Wesley Chapel FL 33543

Anthra Pharmaceuticals, Inc. Princeton NJ 08540

Pharmaquest Corporation 4470 Redwood Highway San Rafael CA 94903

DNage B.V. Darwinweg 24 NETHERLANDS

Gaithersburg MD 20878

Herndon VA 20170

Tucson AZ 85710

Tucson AZ 85710

Nashville TN 37203

Discovery Experimental & Development, Inc.

103 Carnegie Center, Suite 102

Chestnut Run, Maple Run Centre Rd.

Expression Genetics, Inc. 2215 Mock Road Huntsville AL 35801

Vical Incorporated 9373 Towne Center Dr. Suite 100

AVAX Technologies, Inc. Building 9, Suite 200

Luitpold Pharmaceuticals, Inc. 800 Adams Avenue 1st Floor

920 US Highway 202 P. O. Box 300

One Health Plaza

Supratek Pharma Inc. 215Bouchard Blvd Dorval CANADA

BioAlliance Pharma Paris FRANCE

Supratek Pharma, Inc. 215 Bouchard Blvd Dorval, Quebec H9S 1A9 CANADA

Demegen, Inc. 100 Technology Drive Suite 440 B

Thallion Pharmaceuticals, Inc. 7150 Alexander-Fleming H4S 2C8 Montreal CANADA

Chelsea Therapeutics, Inc. Charlotte NC 28277

Lantibio, Inc. 100 Europa Drive Suite 421

DuPont Pharmaceuticals Company

Wilmington DE 19805

San Diego CA 92121-3088

9200 Indian Creek Parkway

Overland Park KS 66210

Valley Forge PA 19403

Johnson & Johnson Pharmaceutical Research & Dev.

Raritan NJ 08869

Novartis Pharmaceuticals Corporation

East Hanover NJ 07936-1080

Quebec H9S 1A9

59, Bd Gal Martial Valin - 75015

Pittsburgh PA 15219

13950 Ballantyne Corporate Place

Chapel Hill NC 27517

Mayo Foundation Rochester MN 55905

Mayo Foundation Rochester MN 55905

Dyax Corp 300 Technology Square Cambridge MA 02139

Alexion Pharmaceuticals, Inc. 352 Knotter Drive Cheshire CT 06410

Alexion Pharmaceuticals, Inc. 352 Knotter Drive Cheshire CT 06410

Alexion Pharmaceuticals, Inc. 352 Knotter Drive Cheshire CT 06410

Novartis Pharmaceuticals Corp. One Health Plaza

Allos Therapeutics, Inc. 11080 CirclePoint Road Suite 200

VBL Pharmaceuticals, Inc. 216 Robin Way Menlo Park CA 94025

Marion Merrell Dow, Inc. P.O. Box 9627 Kansas City MO 64134

Innapharma, Inc. 10 Mountainview Road

Warner-Lambert Company 2800 Plymouth Road

VivoRx 2825 Santa Monica Blvd. 2nd Floor

200 First Street Southwest

200 First Street Southwest

59 Route 10/Bldg 122/N142

East Hanover NJ 07936-1080

Westminster CO 80020

Upper Saddle River NJ 07458

Parke-Davis Pharmaceutical Research Division

Ann Arbor MI 48105

Santa Monica CA 90404-2429

Adherex Technologies, Inc. 4620 Creekstone Drive Research Triangle Park

G.D. Searle & Company 4901 Searle Parkway Skokie IL 60077

G.D. Searle & Company 4901 Searle Parkway Skokie IL 60077

Raptor Therapeutics, Inc. 9 Commercial Boulevard Suite 200

Eli Lilly and Company Lilly Corporate Center Indianapolis IN 46285

Eli Lilly and Company Lilly Corporate Center Indianapolis IN 46285

Chiron Vision 500 Iolab Drive Claremont CA 91711

Ethicon, Inc. P.O. Box 151 Somerville NJ 08876

920 U.S. Highway Route 202, P.O. Box 300

Route 202 South P.O. Box 300

920 US Highway 202

Route 202, P.O. Box 300 Raritan NJ 08869

Chugai-USA, Inc. 3780 Hawthorn Court Waukegan IL 60087

Glaxo Wellcome Inc. 5 Moore Drive

Durham NC 27703

Novato CA 94949-6118

Johnson & Johnson Pharmaceutical Research & Dev.,

Raritan NJ 08869-0602

R. W. Johnson Pharmaceutical Research Institute

Raritan NJ 08869

Ortho Biotech Oncology Research & Development

Johnson & Johnson Pharmaceutical R & D, LLC

Raritan NJ 08869-0602

R. W. Johnson Pharmaceutical Research Institute

Research Triangle Park NC 27709

Upjohn Company 301 Henrietta Street Kalamazoo MI 49001

Immunomedics, Inc. 300 American Road Morris Plains NJ 07950

Immunomedics, Inc. 300 American Road Morris Plains NJ 07950

Neurochem, Inc. Saint-Laurent CANADA

Feigin Center Suite 1120

Genentech, Inc 1 DNA Way

EUSA Pharma (US), Inc. 1980 South Easton Road Suite 250

Lyphomed, Inc.

Organon Teknika Corporation

McDonnell Douglas Corp St. Louis MO 63166

Ascend Therapeutics, Inc. 607 Herndon Parkway Suite 110

Immunex Corporation 51 University Street Seattle WA 98101-2936

Orfagen FRANCE

7220 Frederick Banting, Suite 100

Quebec H4S 2A1

Center for Cell and Gene Therapy

Houston TX 77030-2399

South San Francisco CA 94080-4990

Doylestown PA 18901

P.O. Box 516, 107/2 MS10

Herndon VA 21070

Parc Technologique du Canal

31521 Ramonville Saint Agne Cedex

Orfagen FRANCE

Bio-Technology General Corp. 70 Wood Avenue, South Iselin NJ 08830

U.S. Bioscience 100 Front Street

Laxdale Ltd. UNITED KINGDOM

MGI Pharma, Inc. Suite 110

MGI Pharma, Inc. Suite 110

SuperGen, Inc. San Ramon CA 94583

SuperGen, Inc. Suite 10

One Health Plaza

Osiris Therpeutics, Inc. 2001 Aliceanna Street Baltimore MD 21231-3043

OSI Pharmaceuticals, Inc. 58 South Service Road Suite 110

100 College Road West Princeton NJ 08540

Novo Nordisk, Inc. 100 College Road West Princeton NJ 08540

Parc Technologique du Canal

31521 Ramonville Saint Agne Cedex

West Conshohocken PA 19428

Kings Park House, Laurelhill Business Park

Polmaise Road, Stirling FK7 9JQ

6300 West Old Shakoppe Rd.

Bloomington MN 55438-2318

6300 West Old Shakoppe Rd.

Bloomington MN 55438-2318

Two Annabel Lane, Suite 220

Two Annabel Lane, Suite 220

San Ramon CA 94583

Novartis Pharmaceuticals Corporation

East Hanover NJ 07936-1080

Melville NY 11747

Novo Nordisk Pharmaceuticals, INc.

CSL Behring L.L.C. 1020 First Ave. PO Box 61501

Zymogenetics, Inc. 4225 Roosevelt Way Seattle WA 98105

Acorda Therapeutics 15 Skyline Dr. Hawthorne NY 10532

Acorda Therapeutics, Inc. 15 Skyline Dr. Hawthorne NY 10532

Neuropharm, Ltd. Fetcham Park House UNITED KINGDOM

Cancer Research UK 61 Lincoln's Inn Fields London WC2A 3PX UNITED KINGDOM

4650 Sunset Blve, MS 55

Degussa AG Weissfrauenstr.9 D-60287 Frankfurt GERMANY

Oclassen Pharmaceuticals, Inc. 100 Pelican Way San Rafael CA 94901

Alpha Therapeutic Corporation 5555 Valley Boulevard Los Angeles CA 90032

Melville Biologics, Inc. 310 East 67th Street New York NY 10021

Chiron Vision 9342 Jeronimo Road Irvine CA 92718

Amgen, Inc. 1840 Dehavilland Drive

Amgen, Inc. One Amgen Center Dr.

King of Prussia PA 19406-0901

Leatherhead, Surrey KT22 9HD

USC-CHLA Institute for Pediatric Clinical Research

Childrens Hospital Los Angeles

Los Angeles CA 90027

Thousand Oaks CA 91320

Thousand Oaks CA 91320-1799

Franco Muggia, M.D. 160 East 34th Street New York NY 10016

Berlex Laboratories, Inc. 15049 San Pablo Avenue P.O. Box 4099

Farmacon, Inc. Post House, Suite 213 1720 Post Road East

Janssen Research Foundation P.O. Box 200

Lederle Laboratories 401 N. Middletown Road

Hoffmann-La Roche, Inc. 340 Kingsland Street Nutley NJ 07110-1199

Hoffmann-La Roche, Inc. 340 Kingsland Street Nutley NJ 07110-1199

Ethypharm SA 92213 Saint-Cloud Cedex

Neuropharm, Ltd. Felcham Park House Lower Road, Leatherhead UNITED KINGDOM

Hollander, Eric MD

Gilead Sciences, Ince. 2025 First Avenue Seattle WA 98121

Questcor Pharmaceuticals, Inc. 3260 Whipple Road

1730 Michael Lane

Centocor, Inc. Malvern PA 19355-1307

Richmond CA 94804-0099

Westport CT 06880-5643

Titusville NJ 08560

Division of American Cyanamid Company

Pearl River NY 10965

194 Bureaux de la Colline - Batiment D

The Mount Sinai School of Medicine

One Gustave L. Levy Place

New York NY 10029-6574

Union City CA 94587-1217

The Cure Our Children Foundation

Pacific Palisades CA 90272-2037

200 Great Vallley Parkway

Topo Target A/S Symbion Science Park Fruebjergvej 3 DENMARK

Receptor BioLogix, Inc. 1140 Veterans Blvd. Suite A

Receptor BioLogix, Inc. 1140 Veterans Blvd. Suite A

Warner-Lambert Company 2800 Plymouth Road

Biocraft Laboratories, Inc. 18-01 River Road Fair Lawn NJ 07410

Sigma Chemical Company

Zurier, Robert B. M.D. 55 Lake Avenue

Marinus Pharmaceuticals, Inc. 21 Business Park Drive Branford CT 06405

Sirion Therapeutics, Inc. Tampa FL 33619

Burroughs Wellcome Company 3030 Cornwallis Road P.O. Box 12700

Fidia Pharmaceutical Corp. Washington DC 20005

Amgen One Amgen Center Drive Mail Stop 17-2-A

Memgen, LLC 7557 Rambler Road Dallas TX 75231

Ark Therapeutics Ltd. 1 Fitzroy Mews London UNITED KINGDOM

South San Francisco CA 94080

South San Francisco CA 94080

Parke-Davis Pharmaceutical Research Division

Ann Arbor MI 48105

University of Massachusetts Medical Center

Worcester MA 01655

9314 East Broadway Avenue

Research Triangle Park NC 27709

1401 Eye Street, N.W. Suite 900

Thousand Oaks CA 91320-1799

MediGene, Inc. Suite 230

ProcesScience, Inc (PSI) 117 Woodberry Lane Fayetteville NY 13066

Lipha Pharmaceuticals, Inc. 9 West 57th Street Suite 3825

Liposome Company, Inc. One Research Way Princeton NJ 08540

Teva Neurosciences, Inc. P. O. Box 1005 Horsham PA 19044-8005

TEVA Pharmaceuticals, USA 1090 Horsham Road North Wales PA 19454

Protherics, Inc. Brentwood TN 37027

Threshold Pharmaceuticals, Inc. 1300 Seaport Blvd. Redwood City CA 94063

ProtAffin Biotechnologie AG A-8020 Graz AUSTRIA

Ucyclyd Pharma, Inc 8125 N. Hayden Rd.

Hyperion Therapeutics, Inc. 601 Gateway Blvd. Suite 200

Moser, Hugo W. M.D. Johns Hopkins University

Sciele Pharma, Inc. Five Concourse Parkway Suite 1800

10650 Scripps Ranch Blvd.

San Diego CA 92131

New York NY 10019-2701

5214 Maryland Way, Suite 405

Impulszentrum Graz - West

Chugai Pharmaceutical Co., Ltd.

Subsidiary of Medicis Pharmaceutical Corporation

Scottsdale AZ 85258

South San Francisco CA 94080

Kennedy Krieger Institute, 707 North Broadway

Baltimore MD 21205

Atlanta GA 30328

GlycoMimetics, Inc. 101 Orchard Ridge Drive Gaithersburg MD 20878

Gradalis, Inc. 2545 Golden Bear Drive Carrollton TX 75006

Centocor, Inc. Malvern PA 19355-1307

Reidenberg, Marcus M. M.D.

Genzyme Corporation 500 Kendall Street Cambridge MA 02142

DrugRecure Aps Scion DTU Boge alle 5, 1,tv DENMARK

Schering Corporation 2000 Galloping Hill Road Kenilworth NJ 07033

Schering Corporation 2000 Galloping Hill Road Kenilworth NJ 07033

Schering Corporation 2000 Galloping Hill Road Kenilworth NJ 07033

Schering Corporation 2000 Galloping Hill Road Kenilworth NJ 07033

Schering Corporation 2000 Galloping Hill Road Kenilworth NJ 07033

North American Biologicals, Inc. 12280 Wilkins Avenue Rockville MD 20852

One Enterprise Way Aliso Viejo CA 92656

59 Route 10

Watson Laboratories, Inc. 311 Bonnie Circle PO Box 1900

200 Great Valley Parkway

The New York Hospital - Cornell Medical Center

525 East 68th Street, Box 70

New York NY 10021

Valeant Pharmaceuticals International

Novartis Pharmaceuticals Corporation

East Hanover NJ 07936-1080

Corona CA 91718-1900

5 Research Parkway P.O. Box 5100

Tel-Aviv 68012 ISRAEL

9801 Washingtonian Blvd Suite 220

CPL, Inc. Suite 145

Orphan Europe Immeuble Le Guillaumet 92046 Paris La Defense FRANCE

Orphan Europe Immeuble Le Guillaumet FRANCE

Bonkovsky, Herbert L. M.D. 55 Lake Avenue North

Apex Bioscience, Inc. 109 Conner Drive `

Vectura Group, Inc. 1 Prospect West Wiltshire SN14 6FH UNITED KINGDOM

Ockham Biotech Limited Manor Farm 98 Swanwick Lane UNITED KINGDOM

Trillium Therapeutics, Inc. 96 Skyway Avenue M9W 4Y4 CANADA

Boca Raton FL 33487

Boca Raton FL 33487

Cubist Pharmaceuticals 65 Hayden Avnue Lexington MA 02421

Bristol-Myers Squibb Pharmaceutical Research Institute

Wallingford CT 06492-7660

Collgard Biopharmaceuticals Ltd.

Textile House, 2 Koifman St.

Cadila Pharmaceuticals Limited, Inc.

Gaithersburg MD 20878

16020 Swingley Ridge Road

Chesterfield MO 63017

70 avenue du General de Gaulle,

92056 Paris La Defense

University Of Massachusetts Medical Center

Worcester MA 01655

Chapel Hill NC 27514

Biotest Pharmaceuticals Corporation

5800 Park of Commerce Blvd., NW

Biotest Pharmaceuticals Corporation

5800 Park of Commerce Blvd, NW

Genetic Therapy, Inc. 938 Clopper Road Gaithersburg MD 20878

EpiCept Corporation Tarrytown NY 10591

EpiCept Corporation Tarrytown NY 10591

Anderson, Karl E., M.D.

Hemacare Corporation Sherman Oaks CA 91403

Vical Incorporated San Diego CA 92121

American BioScience, Inc. 2730 Wilshire Blvd. #110 Santa Monica CA 90403

Rhone-Poulenc Rorer Pharm. 500 Arcola Road Collegeville PA 19426

Gliknik, Inc. 801 W. Baltimore Street Baltimore MD 21201

6055 Lusk Boulevard

PDL BioPharma, Inc. 34801 Campus Drive Fremont CA 94555

Pharming/Genzyme LLC c/o Genzyme Corporation 1 Mountain Rd.

1801 Maple Avenue Suite 4300

Medarex, Inc. 519 Route 173 West Bloomsbury NJ 08804

777 Old Saw Mill River Road

777 Old Saw Mill River Road

University of Texas Medical Branch at Galveston

Route J-09, 700 The Strand

Galveston TX 77550

4954 Van Nuys Boulevard

9373 Towne Centre Dr., Suite 100

StressGen Biotechnologies, Inc. is now Nventa

Nventa Biopharmaceuticals Corporation

San Diego CA 19426-2655

Framingham MA 01701-9322

Falk Center for Molecular Therapeutics

Evanston IL 60201

Genmab A/S Tolbodgade 33 DK-1253 Copenhagen K DENMARK

BioInvent International AB Solvegatan 41 SWEDEN

Centocor, Inc. Malvern PA 19355-1307

Centocor, Inc. Malvern PA 19355-1307

Genzyme Corporation One Kendall Square Cambridge MA 02139

Genzyme Corporation 500 Kendall Street Cambridge MA 02142

Bone Therapeutics S.A. 8, rue Adrienne Bolland BELGIUM

3 Avenue des Tropiques 91985 Courtaboeuf Cedex FRANCE

Biotest Diagnostics Corporation 66 Ford Road Denville NJ 07834

Bio Products Laboratory Dagger Lane Hertfordshire, WD6 3BX UNITED KINGDOM

Protein Therapeutics, Inc. 70 Calle Encanto Tucson AZ 85716

Protein Therapeutics, Inc. 70 Calle Encanto Tucson AZ 85716

Protein Therapeutics, Inc. 70 Calle Encanto Tuscon AZ 85716

Centocor, Inc. Malvern PA 19355

200 Great Valley Parkway

200 Great Valley Parkway

Laboratoire francais du Fractionnement et des Biot

244 Great Valley Parkway

Centocor, Inc. Malvern PA 19355

Pharmalink AB P. O. Box 625 SWEDEN

NABI Boca Raton FL 33487

NABI Boca Raton FL 33487

NABI Boca Raton FL 33487

Medarex, Inc. 519 Route 173 West Bloomsbury NJ 08804

5 Research Parkway

IRX Therapeutics, Inc. 140 West 57th Street New York City NY 10019

CuraGen Corporation 322 East Main Street Branford CT 06405

Kenta Biotech Limited Rehhagstrsase SWITZERLAND

One Health Plaza

Centocor, Inc. Malvern PA 19355-1307

Octapharma USA, Inc. 121 River Street 12th Floor

Octapharma USA, Inc. 121 River Street 12th Floor

Enobia Pharma, Inc. 2901 Rachel Street East Montreal, QC H1W 4A4 CANADA

244 Great Valley Parkway

5800 Park of Commerce Blvd., NW

5800 Park of Commerce Blvd., N.W.

5800 Park of Commerce Blvd., NW

Bristol-Myers Squibb Pharmaceutical Research Insti

Signature 91 Bldg/3SIG-3012

Wallingford CT 06492

Novartis Pharmaceuticals Corporation

East Hanover NJ 07936-1080

200 Great Valley PArkway

Hoboken NJ 07030

Hoboken NJ 07030

GemVax A/S Drammensveien 100 0273 Oslo NORWAY

MicroGeneSys, Inc. 1000 Research Parkway Meriden CT 06450

Centocor, Inc Malvern PA 19355-1307

MedImmune, Inc. 35 West Watkins Mill Rd. Gaithersburg MD 20878

MacroGenics, Inc. 1500 East Gude Drive Rockville MD 20850

Genzyme Corporation 500 Kendall Street Cambridge MA 02142

Biotransplant, Inc. Building 75, 3rd. Ave. Charlestown Navy Yard

Hoffmann-La Roche, Inc. 340 Kingsland Street Nutley NJ 07110-1199

Selexys Pharmaceuticals Corp. 800 Research Parkway Suite 338

Biogen IdecInc. 3030 Callan Rd. San Diego CA 92121

Teijin America, Inc. 600 Alexander Park Suite 304

Morphotek, Inc. 210 Welsh Pool Road Exton PA 19341

Stromedix, Inc. One Canal Park Cambridge MA 02141

CoTherix 5000 Shoreline Court Suite 101

Barbeau Pharma, Inc. 790 W. Frontage Road Suite 125

200 Great Valley Parkway

Charlestown MA 02129

Oklahoma OK 73104

Princeton NJ 08540

South San Francisco CA 94080

Northfield IL 60093

DuoCort AB SWEDEN

Jazz Pharmaceuticals 3180 Porter Drive Palo Alto CA 94304

Hall, Alan H., M.D. PO Box 24

UPM Pharmaceuticals, Inc. 6200 Seaforth Street Baltimore MD 21224

Nexell Therapeutics Wilmington DE 19808

Nexell Therapeutics, Inc. Wilmington DE 19808

TransMolecular, Inc. 840 Memorial Drive Second Floor

GlaxoSmithKline PO Box 13398 Five Moore Drive

Farmacon-IL, LLC 1720 Post Road East Suite 213

Jerini AG Invalidenstr, 130 10115 Berlin GERMANY

Jerini AG A subsidiary of Shire PLC Invalidenstr. 130 GERMANY

Pharmacia & Upjohn 7000 Portage Road Unit 0633-298-113

Pharmacia & Upjohn 7000 Portage Road Unit 0633-298-113

Kullagatan 8-10, S-252 20 Helsingborg

Mile 5.0 Pass Creek Road

Elk Mountain WY 82324

2751 Centerville Rd., Suite 210

2751 Centerville Rd., Suite 210

Cambridge MA 02139 Research Triangle Park NC 27709-3398

Westport CT 06880-5643

Kalamazoo MI 49001-0199

Kalamazoo MI 49001-0199

Pharmacia & Upjohn 7000 Portage Road Unit 0633-298-113

Hammerstrasse 47 SWITZERLAND

Hammerstrasse 47 SWITZERLAND

Santhera Pharmaceuticals LLC Hammerstrasse 25 CH-4410 Liestal SWITZERLAND

NeoPharm, Inc. Lake Forest IL 60045

ArmaGen Technologies, Inc. 914 Colorado Ave. Santa Monica CA 90401

Bristol-Myers Squibb Company P.O. Box 4000 Mail Stop D12-02

P.O. Box 4000 Princeton NJ 08543

NeoPharm, Inc. 150 Field Drive Suite 195

Protox Therapeutics, Inc. 1210-885 West Georgia San Diego CANADA

Berlex Laboratories, Inc. 300 Fairfield Road Wayne NJ 07470

Berlex Laboratories, Inc. 300 Fairfield Road Wayne NJ 07470

Centocor, Inc. Malvern PA 19355

AmpliMed Corporation 4380 N. Campbell Ave. Tucson AZ 85718

Kalamazoo MI 49001-0199

Santhera Pharmaceuticals Limited

Santhera Pharaceuticals Limited

225 East Deerpath, Suite 250

Princeton NJ 08543-4000

Bristol-Myers Squibb Pharmaceutical Research Institute

Lake Forest IL 60045

Vancouver, British Columbia

244 Great Valley Parkway

AmpliMed Corporation 2321 Camino La Zorrela Tucson AZ 85718

AmpliMed Corporation 2321 Camino La Zorrela Tucson AZ 85718

AmpliMed Corporation 2321 Camino La Zorrela Tucson AZ 85718

Vital Therapies, Inc. 15222 Avenue of Science Suite C

Ramat Gan 52621 ISRAEL

ZLB Bioplasma AG Wankdorfstrasse 10 CH-3000 Bern 22 SWITZERLAND

Baxter Healthcare Corporation, Baxter Bioscience

750 Lexington Avenue New York NY 10022

155 East 56th Street New York NY 10022

New York NY 10022

CSL Behring 1020 First Avenue P.O. Box 61501

2 Tesseneer Drive

2 Tesseneer Drive

ALK Laboratories, Inc. Research Center 27 Village Lane

San Diego CA 92128

OMRIX Biopharmaceuticals, Ltd.

Plasma Fractionation Institute

Westlake Village CA 91362

Immuno Clinical Research Corp.

Immuno Clinical Research Corp.

Immuno Clinical Research Corp.

750 Lexington Avenue, 19th Floor

King of Prussia PA 19406-0901

Medical Research Laboratories International

Highland Heights KY 41076

Medical Research Laboratories International

Highland Heights KY 41076

Wallingford CT 06492

Therion Biologics Corporation 76 Rogers Street Cambridge MA 02142

Centocor, Inc. Malvern PA 19355

Hybritech, Inc. 11095 Torreyanna Road San Diego CA 92196

9701 Richmond Avenue Houston TX 77042

Centocor, Inc. 200 Great Valley Parkway

Centocor, Inc. Malvern PA 19355-1307

Centocor, Inc. Malvern PA 19355-1307

Centocor, Inc. Malvern PA 19355-1307

Introgen Therapeutics, Inc. 2250 Holcombe Blvd

Inhibitex, Inc. 8995 Westside Parkway Suite 150

EUSA Pharma 650 College Road East Suite 3100

Newport Pharmaceuticals Newport Beach CA 92663

Hoffmann-La Roche, Inc. 340 Kingsland Street Nutley NJ 07110-1199

Hoffmann-La Roche, Inc. 340 Kingsland Street Nutley NJ 07110

244 Great Valley Parkway

RadioIsotope Therapy of America (RITA) Foundation

Malvern PA 19355-1307

200 Great Valley Parkway

200 Great Valley Parkway

200 Great Valley Parkway

Houston TX 77030

Alpharetta GA 30004

Princeton NJ 08540

897 West Sixteenth Street

Hoffmann-La Roche, Inc. 340 Kingsland Street Nutley NJ 07119

Hoffmann-La Roche, Inc. 340 Kingsland Street Nutley NJ 07110-1199

Hoffmann-La Roche, Inc. 340 Kingsland Street Nutley NJ 07110-1199

Schering Corporation 2000 Galloping Hill Road Kenilworth NJ 07033

Schering Corporation 2000 Galloping Hill Road Kenilworth NJ 07033

Schering Corporation 2000 Galloping Hill Road Kenilworth NJ 07033

Schering Corporation 2000 Galloping Hill Road Kenilworth NJ 07033

Schering Corporation 2000 Galloping Hill Road Kenilworth NJ 07033

Schering Corporation 2000 Galloping Hill Road Kenilworth NJ 07033

Schering Corporation 2000 Galloping Hill Road Kenilworth NJ 07033

Schering Corporation 2000 Galloping Hill Road Kenilworth NJ 07033

Schering Corporation 2000 Galloping Hill Road Kenilworth NJ 07033

Glaxo Wellcome Inc. 5 Moore Drive

Burroughs Wellcome Company 3030 Cornwallis Road

Research Triangle Park NC 27709

Research Triangle Pk NC 27709

Biogen, Inc. 14 Cambridge Center Cambridge MA 02142

Biogen, Inc. 14 Cambridge Center Cambridge MA 02142

Biogen, Inc. 14 Cambridge Center Cambridge MA 02142

Berlex Laboratories, Inc. Richmond CA 94804

EMD Serono, Inc. One Technology Place Rockland MA 02370

Biogen, Inc. 14 Cambridge Center Cambridge MA 02142

Biogen, Inc. 14 Cambridge Center Cambridge MA 02142

Biogen, Inc. 14 Cambridge Center Cambridge MA 02142

EMD Serono, Inc. One Technology Place Rockland MA 02370

Herrengasse 21 Furstentum Liechtenstein GERMANY

InterMune, Inc. 3280 Bayshore Boulevard Brisbane CA 94005

Genentech, Inc. 1 DNA Way

Ernest C.Borden 9500 Euclid Avenue

Immunex Corporation 51 University Street Seattle WA 98101

Immunex Corporation 51 University Street Seattle WA 98101

15049 San Pablo Avenue, P.O. Box 4099

Foundation for Fatal Rare Diseases

South San Francisco CA 94080-4990Center for Cancer Drud

Discovery and Development

Clevland OH 44195

Amgen, Inc. One Amgen Center Drive

Amgen, Inc. One Amgen Center Drive

Tarrytown NY 10591

Hoffmann-La Roche, Inc. 340 Kingsland Street Nutley NJ 07110

Hoffmann-La Roche, Inc. 340 Kingsland Street Nutley NJ 07110

Hoffmann-La Roche, Inc. 340 Kingsland Street Nutley NJ 07110

Hoffmann-La Roche, Inc. 340 Kingsland Street Nutley NJ 07110

Immunex Corporation 51 University Street Seattle WA 98101

Sandoz Pharmaceuticals Corp. 59 Route 10 East Hanover NJ 07936

Digestive Care, Inc. 1120 Win Drive Bethlehem PA 18017

GammaCan Ltd. 39 Jerusalem Street ISRAEL

Octapharma USA, Inc. 121 River Street Hoboken NJ 07030

DraxImage Kirkland, Quebec H9H 4J4 CANADA

160 Second street Cambridge MA 02142

Brogan Pharmaceuticals, LLC 312 Lacebark Street Schererville IN 46375

Thousand Oaks CA 91320-1799

Thousand Oaks CA 91320-1799

Regeneron Pharmaceuticals, Inc.

777 Old Saw Mill River Road

Div. of Draxis Specialty Pharmaceuticals, Inc.

Molecular Insight Pharmaceuticals

Brogan Pharmaceuticals, Inc. 9800 Connecticut Drive

David E. Kuhl, M.D.

Immunomedics, Inc. 300 American Road Morris Plains NJ 07950

Immunomedics, Inc. 300 American Road Morris Plains NJ 07950

Immunomedics, Inc. 300 American Road Morris Plains NJ 07950

IBC Pharmaceuticals, L.L.C. 300 American Rd. Morris Plains NJ 07950

Lederle Laboratories Division 401 N. Middletown Road

Immunomedics, Inc. 300 American Road Morris Plains NJ 07950

Immunomedics, Inc. 300 American Road Morris Plains NJ 07950

Immunomedics, Inc. 300 American Road Morris Plains NJ 07950

Immunomedics, Inc. 300 American Road Morris Plains NJ 07950

Peregrine Pharmaceuticals, Inc. 14282 Franklin Ave. Tustin CA 92780-7017

Eisai Medical Research, Inc. 55 Challengaer Road Ridgefield Park NJ 07660

Eisai Medical Research, Inc. 55 Challenger Road

c/o Purdue Technology Center

Crown Point IN 46307

University of Michigan Medical Center/1500 E. Med.

B1G412 /0028 University Hospital

Ann Arbor MI 48109-0028

American Cyanamide Company

Pearl River NY 10965

Rodgefield Park NJ 07660

Alpha Therapeutic Corporation 5555 Valley Boulevard Los Angeles CA 90032

Perrine, Susan P., M.D. Boston University Cancer Research Center

Amicus Therapeutics, Inc. 6 Cedar Brook Drive Cranbury NJ 08512

Fairfield Clinical Trials, LLC 200 Steep Hill Road Weston CT 06883

Academic Pharmaceuticals 21 N. Skokie Hwy Lake Bluff IL 60044

Incyte Corporation Experimental Station Bldg E400/6430

Glovax Co., Ltd.

Pharmedic Company 28101 Ballard Road Lake Forest IL 60045

Pharmalucence, Inc. 10 DeAngelo Drive Bedford MA 01730

Transcend Therapeutics, Inc. Cambridge MA 02139

Transcend Therapeutics, Inc. Cambridge MA 02139

Watson Laboratories, Inc. 311 Bonnie Circle P.O. Box 1900

Frontier Pharmaceutical, Inc. SUNY Farmingdale Conklin Hall

VSL Pharmaceuticals, Inc. 800 S. Frederick Avenue Gaithersburg MD 20877

VSL Pharmaceuticals, Inc. 800 S. Frederick Ave. Gaithersburg MD 20877

Boston MA 02118

Wilmington DE 19880

Room 307, Koryo Academytel, 437-3

Ahyun-Dong, Mapo-Gu, Seoul 121-010

640 Memorial Drive, 3rd Floor West

640 Memorial Drive, 3rd Floor West

Corona CA 91718-1900

Farmingdale NY 11735

Roxane Laboratories, Inc. P.O. Box 16532

CepTor Corporation 200 International Circle Hunt Valley MD 21030

Vion Pharmaceuticals, Inc. Four Science Park New Haven CT 06511

Rare Disease Therapeutics, Inc. 2550 Meridian Blvd. Franklin TN 37067

Fromm, Gerhard M.D. Pittsburgh PA 15261

Osmotica Kft.

Osmotica Kft.

Osmotica Kft.

Lev, Meir M.D.

Brigham and Women's Hospital Channing Laboratory Dept. of Medicine

Williams, MD, James W.

Celgene Corporation 86 Morris Avenue Summit NJ 07901

Celgene Corporation 86 Morris Avenue Summit NJ 07901

Columbus OH 43216-6532

University Of Pittsburgh School of Medicine

The City College, City University Of NY Medical Sc

Convent Avenue at 138 Street

New York NY 10031

Boston MA 02115

Rush-Presbyterian-St. Luke's Medical Ctr., Dept. o

1653 West Congress Parkway

Chicago IL 60612-3833

Errant Gene Therapeutics, LLC Suite 300

Cephalon, Inc. 41 Moores Road Frazer PA 19355

5 Moore Drive PO Box 13398

CEL-SCI Corporation 8229 Boone Blvd. Suite 802

Neuromuscular Adjuncts, Inc. S.U.N.Y. at Stony Brook H.S.C. T18-020

Iolab Pharmaceuticals 500 Iolab Drive Claremont CA 94608

Suite 500

9841 Washingtonian Blvd Suite500

Suite 500

9841 Washingtonian Blvd Suite 500

9841 Washingtonian Blvd Suite 500

Solvay Pharmaceuticals, Inc. 901 Sawyer Road Marietta GA 30062

Mpex Pharmaceuticals, Inc. San Diego CA 92121

Emmaus Medical, Inc. 3870 Del Amo Blvd Unit 507

Implicit Bioscience Pty Ltd P. O. Box 2072. Toowong Business Center AUSTRALIA

218 North Jefferson Street

Chicago IL 60661

Glaxo Wellcome Research and Development

Research Triangle Park NC 27709

Vienna VA 22182

Stony Brook NY 11794-8181

Sigma-Tau Pharmaceuticals, Inc.

9841 Washingtonian Blvd.

Gaithersburg MD 20878

Sigma-Tau Pharmaceuticals, Inc.

Gaithersburg MD 20878

Sigma-Tau Pharmaceuticals, Inc.

9841 Washingtonian Blvd.

Gaithersburg MD 20878

Sigma-Tau Pharmaceuticals, Inc.

Gaithersburg MD 20878

Sigma-Tau Pharmaceuticals, Inc.

Gaithersburg MD 20878

11535 Sorrento Valley Road

Torrance CA 90503-7701

Barrier Therapeutics, Inc 600 College Road East Princeton NJ 08540

Seattle Genetics, Inc. Bothell WA 98021

Seattle Genetics, Inc. Bothell WA 98021

Protein Design Labs, Inc. 34801 Campus Drive Fremont CA 94555

Genzyme Corporation Metrowest Place P.O. Box 9322

Fujisawa USA, Inc. 3 Parkway North Center Deerfield IL 60015

Callisto Pharmaceuticals, Inc. 420 Lexington Avenue New York NY 10170

Callisto Pharmaceuticals, Inc. 420 Lexington Avenue New York NY 10170

Aradigm Corporation 3929 Point Eden Way Hayward CA 94545

Aradigm Corporation 3929 Point Eden Way Hayward CA 94545

Transave, Inc. 11 Deer Park Drive

Vernon Knight, M.D. One Baylor Plaza

PARI Pharma GmbH Moosstrasse 3 GERMANY

GP-Pharm SA Quinti de Mediona Barcelona SPAIN

MedGenesis Therapeutix, Inc. 730-730 View Street Victoria, BC V8W 3Y7 CANADA

21823 30th Drive Southeast

21823 30th Drive Southeast

Framingham MA 01701-9322

Monmouth Junction NJ 08852-1923

Baylor College of Medicine, Dept. of Molecular Phy

Houston TX 77030

Pol. Ind. Els Vinyets els Fogars n 2,

Endorex Corp. 900 North Shore Drive Lake Bluff IL 60044

Endorex Corp. 900 North Shore Drive Lake Bluff IL 60044

The University of Texas Unit 038

Bio-Path, Inc. Ogden UT 84403

Liposome Company, Inc. One Research Way Princeton NJ 08540

MedGenesis Therapeutix, Inc. 730-730-View Street Victoria, BC, V8W 3Y7 CANADA

Antigenics Incorporated 3 Forbes Road Lexington MA 02421

Oncothyreon Canada, Inc. 2011-94 St., NW Suite 200 CANADA

Oncothyreon Canada, Inc. 2011 - 94th Street NW 200 Edmonston, AB CANADA

Cell Therapeutics, Inc. Suite 400

Spectrum Pharmaceuticals, Inc. 157 Technology Drive Irvine CA 92618

Route 202, P.O. Box 300 Raritan NJ 08869

Lexington MA 02421-7966

M.D. Anderson Cancer Center

Houston TX 77030

3293 Harrison Blvd., Suite 230

201 Elliot Avenue West201

Seattle WA 98119

R. W. Johnson Pharmaceutical Research Institute

Interneuron Pharmaceuticals, Inc.

99 Hayden Ave., Suite 200

Tyson And Associates 12832 Chadron Avenue Hawthorne CA 90250

Nyxis Neurotherapies, Inc. 1801 Maple Avenue Suite 4300

510 King's Rd North Point HONG KONG

Discovery Laboratories, Inc 2600 Kelly Road Warrington PA 18976

Discovery Laboratories, Inc. 2600 Kelly Road Warrington PA 18976

Discovery Laboratories, Inc. 2600 Kelly Road Warrington PA 18976

Discovery Laboratories, Inc. 2600 Kelly Road Warrington PA 18976

Discovery Laboratories, Inc. 2600 Kelly Road Warrington PA 18976

G.D. Searle & Company 4901 Searle Parkway Skokie IL 60077

Vivendy Therapeutics LTD Peter Merian -Strasse 45 SWITZERLAND

Celsion Corpora tion Columbia MD 21046

Actelion Pharmaceuticals Ltd. Gewerbestrasse 16 SWITZERLAND

Baxter Healthcare Corporation Route 120 & Wilson Road

Gliknik, Inc. 801 W. Baltimore Street Baltimore MD 21201

Evanston IL 60201

CMS Peptides Patent Holding Company Limited

Unit 2106, 21st Floor, Island Place Tower

10220-L Old Columbia Road

Round Lake IL 60073-0490

ARIAD Pharmaceuticals, Inc 26 Landsdowne Street

ActivBiotics, Inc. 110 Hartwell Avenue Lexington MA 02421

Pharmaxis Ltd. 10 Rodborough Rd. NSW 2086 AUSTRALIA

Progen Industries Limited P. O. Box 28 Richlands 4077 AUSTRALIA

ViroPharma Inc. 730 Stockton Drive Exton PA 19341

3 Francis St. Belmont MA 02478

Glycomed, Inc 860 Atlantic Avenue Alameda CA 94501

10865 Altman Row Suite 200

Collipp, Platon J. M.D. 176 Memorial Drive Jesup GA 31545

Targacept, Inc. 200 East First St. Suite 300

Insmed, Inc. Richmond VA 23235

Cephalon, Inc. 41 Moores Road P. O. Box 4011

Yaupon Therapeutics, Inc. Radnor PA 19087

MedImmune, LLC One MedImmune Way Gaithersburg MD 20878

Cambridge MA 02139-4234

Multidisciplinary Association for Psychedelic Studies, Inc.

GenStar Therapeutics Corporation

San Diego CA 92121-1113

Winston-Salem NC 27101-4165

8720 Stony Point Parkway

Frazer PA 19355

259 Radnor Chester Road

821 Westview Street Philadelphia PA 19119

Mepha AG 4143 Dornach POSTFASH 137 SWITZERLAND

Mepha AG 4143 Dornach POSTFASH 137 SWITZERLAND

Building 41

CancerVax Corporation 2110 Rutherford Road Carlsbad CA 92008

5 Research Parkway P. O. Box 5100

533 Old Corvallis Road Hamilton MT 59840

Neurim Pharmaceuticals, Ltd. 8 Hanechoshet St. Tel-Aviv ISRAEL

Sack, Robert, M.D.

CyDex Pharmaceuticals, Inc. 10513 W. 84th Terrace Lenexa KS 66214

5 Moore Drive PO Box 13398

Delcath Systems, Inc. Rockefeller Center New York NY 10020

Delcath Systems, Inc. Rockefeller Center 23rd Floor

Cinergen, LLC 146 Medinah Drive Blue Bell PA 19422-3212

ZaBeCor Pharmaceutical Company, LLC

Hoag Memorial Hospital Presbyterian

Hoag Cancer Center Cell Biology Laboratory

Newport Beach CA 92658

Bristol-Myers Squibb Research Inst

Wallingford CT 06492

Ribi ImmunoChem Research, Inc.

Oregon Health Sciences University

3181 S.W. Sam Jackson Park Road

Portland OR 97201

Glaxo Wellcome Research and Development

Research Triangle Park NC 27709

New York NY 10020

Cinergen 146 Medinah Drive Blue Bell PA 19422-3212

P.O. Box 7929 Philadelphia PA 19101

AstraZeneca Pharmaceuticals 1800 Concord Pike PO Box 15437

Shire 725 Chesterbrook Blvd. Wayne PA 19087-5637

Asta Medica , Inc. 890 East St.

Genopia USA, Inc. 90 Gold Street, 6N New York NY 10038

Wyeth-Ayerst Laboratories P.O. Box 8299

Echo Therapeutics, Ltd. 10 Forge Parkway Franklin MA 02038

Therakos, Inc. 437 Creamery Way Exton PA 19431

Amylin Pharmaceuticals, Inc. 9360 Towne Centre Drive San Diego CA 92121

Amylin Pharmaceuticals, Inc. 9360 Towne Center Drive San Diego CA 92121

Formac Pharmaceuticals, NV Gaston Geenslaan 1 BELGIUM

Galderma Laboratories, Inc. P.O. Box 331329 Fort Worth TX 76163

GlaxoSmithKline Pharmaceuticals

Wilmington DE 19850-5437

Tewksbury MA 01876-1496

Philadelphia PA 19101-8299

Searle 4901 Searle Parkway Skokie IL 60077

S.L.A. Pharma (UK) Ltd Elite House Leavesden UNITED KINGDOM

Aton Pharma, Inc. 3150 Brunswick Place Lawrenceville NJ 08648

Tau Therapeutics, LLC 2988 Cove Trace Charlottesville VA 22911

Tau Therapeutics, LLC 2988 Cove Trace Charlottesville VA 22911

Cav-Con, Inc. 55 Knollwood Road Farmington CT 06032

Thrombotargets Corp. 2530 Meridian Parkway Durham NC 27713

Thrombotargets Corp. 2530 Meridian Parkway Suite 3023

Schwarz Biosciences, Inc. Raleigh NC 27617

Immuno-Designed Molecules 9 Parker Irvine CA 92618-1605

HRA Pharma 15 , rue Beranger 75003 Paris FRANCE

Corcept Therapeutics, Inc. 149 Commonwealth Drive Menlo Park CA 94025

Actelion Pharmaceuticals Ltd Innovation Centre CH-4123, Allschwil SWITZERLAND

Immunomedics, Inc. 300 American Road Morris Plains NJ 07950

Watford WD25 7SA

Durham NC 27713

8010 Arco Corporate Drive

Immunomedics, Inc. 300 American Road Morris Plains NJ 07950

AUSTRIA

Paladin Labs (USA), Inc. 160 Greentree Drive Suite 101

Lederle Laboratories Division 401 N. Middletown Road

Gynuity Health Projects, LLC 15 East 26th Street New York NY 10010

ILEX Oncology, Inc. 4545 Horizon Hill Blvd.

Biopharmaceutics, Inc. 990 Station Road Bellport NY 11713

Biopharmaceutics, Inc. 990 Station Road Bellport NY 11713

Mobius Therapeutics, Inc. 743 Spirit 40 Park Drive Chesterfield MO 63005

IOP Inc. Costa Mesa CA 92626

Immunomedics, Inc. 300 American Rd. Morris Plains NJ 07950

Immunomedics, Inc. 300 American Road Morris Plains NJ 07950

Schering Corporation 2000 Galloping Hill Road Kenilworth NJ 07033

ExperGen Drug Development GmbH

Hernalser Haupstrasse 24/16

Dover DE 19904

Division of American Cyanamid Company

Pearl River NY 10965

Autoimmunity Research Foundation

Autoimmunity Research, Inc. Thousand Oaks CA 91360

San Antonio TX 78229-2263

3100 Airway Avenue, Suite 106

Schering Corporation 2000 Galloping Hill Road Kenilworth NJ 07033

Ester Neurosciences Ltd. 11 HaManoflm St. ISRAEL

3030 Callan Road San Diego CA 92121

11011 Torreyana Road San Diego CA 92121

Centocor, Inc. Malvern PA 19355

PO Box 14186 One Park Drive

VivoRx Autoimmune, Inc. Santa Monica CA 90404

Protein Design Labs, Inc. 2375 Garcia Avenue Mountain View CA 94043

Protein Design Labs, Inc. 2375 Garcia Avenue Mountain View CA 94043

Protein Design Labs, Inc. 34801 Campus Dr. Fremont CA 94555

ViRexx Medical Corporation 8223 Roper Road Edmonton CANADA

Pfizer, Inc. 235 East 42nd Street New York NY 10017

Glaxo Wellcome Inc. 5 Moore Drive PO Box 13398

Pharmacyclics, Inc. 999 East Arques Avenue

Ackerstein Towers, Bldg B, 10th Floor

IDEC Pharmaceuticals Corporation

IDEC Pharmaceuticals Corporation

244 Great Valley Parkway

United Therapeutics Corporation

Research Triangle Park NC 27709

2825 Santa Monica Blvd., Suite 200

Research Triangle Park NC 27709

Sunnyvale CA 94085-4521

FeRx Incorporated Suite #250

North American Biologicals, Inc. 12280 Wilkins Avenue Rockville MD 20852

North American Biologicals, Inc. 12280 Wilkins Avenue Rockville MD 20852

One Health Plaza

Astra Pharmaceuticals, L.P. 725 Chesterbrook Blvd. Wayne PA 19087-5677

Peregrine Pharmaceuticals, Inc. 14272 Franklin Ave. Suite 100

Antisoma plc West Africa House Hanger Lane Ealing UNITED KINGDOM

475 Huntington Drive San Marino CA 91108

475 Huntington Drive San Marino CA 91108

Glendale CA 91203

Statens Seruminstitut 5 Artillerivej DK-2300 Copenhagen S SWEDEN

Hoffman-La Roche, Inc. 340 Kingsland Street Nutley NJ 07110

AutoImmune, Inc. 128 Spring Street Lexington MA 02173

Abbott Nutrition Abbott Laboratories 625 Cleveland Ave.

4330 La Jolla Village Drive

San Diego CA 92122

Novartis Pharmaceuticals Corporation

East Hanover NJ 07936-1080

Tustin CA 92780

London W5 3QR

Epeius Biotechnologies Corporation

Epeius Biotechnologies Corporation

Epeius Biotechnologies Corporation

345 Pioneer Drive, 1803W

Columbus OH 43215-1724

Orexo AB Box 303 Virdings alle 32 A SWEDEN

AB Science 3, avenue George V FRANCE

Aegerion Pharmaceuticals, Inc. Center Pointe IV Suite 304

Amgen, Inc. One Amgen Center Drive

Vertex Pharmaceuticals, Inc. 130 Waverly St.

MethylGene 7220 Frederick Banting St. Laurant CANADA

MethylGene 7220 Frederick Banting Quebec H4S 2A1 CANADA

Ambit Biosciences Corporation San Diego CA 92121

AB Science 3, avenue George V FRANCE

Abbott Laboratories D-491, AP30-1E

CytRx Corporation 3030 Bunker Hill Street Suite 101

Abbott Laboratories 200 Abbott Park Road

Abbott Laboratories 200 Abbott Park Road

93 Worcester Street Suite 101

Pfizer, Inc. 50 Pequot Avenue 6025-A3106

Bridgewater NJ 08807

Thousand Oaks CA 91320-1799

Cambridge MA 02139-4242

4215 Sorrento Valley Boulevard

Pharmaceuticals Products Division

Abbott Park IL 60064-6157

San Diego CA 92109

Global Pharmaceuticals Research & Development

Abbott Park IL 60064-6157

Global Pharmaceuticals Research & Development

Abbott Park IL 60064-6157

Coley Pharmaceuticals Group, Inc.

Wellesley MA 02481

New London CT 06320

NeuroSearch A/S 93 Pederstrupvej DK-2750 Ballerup DENMARK

Boca Raton FL 33487

Cook Pharma 109 Graylyn Drive Chapel Hill NC 27516

Juncos Industrial Park PUERTO RICO

William M. Lee, MD, FACP 5323 Harry Hines Blvd

ExSAR Corporation 11 Deer Park Drive

Medco Research, Inc. 8455 Beverly Blvd. Suite 308

NAPA of the Bahamas Dubuque IA 52002

Abbott Laboratories 200 Abbott Park Road

Sequella, Inc. Rockville MD 20850

Amarillo Biosciences, Inc. 4134 Business Park Drive Amarillo TX 79110

Amarillo Biosciences, Inc. 4134 Business Park Drive Amarillo TX 79110

Amarillo Biosciences, Inc. 4134 Business Park Drive Amarillo TX 79110

WATSON Laboratories, Inc. 33 Ralph Avenue P.O. Box 30

Biotest Pharmaceuticals Corporation

5800 Park of Commerce Blvd., NW

Galephar Pharmaceutical Research, Inc.

Road 198, No. 100 km. 14.7

Juncos 00777-3873University of Texas

Southwestern Medical Center at

Dallas TX 75390-9151

Monmouth Junction NJ 08852

Los Angeles CA 90048

3560 Pennsylvania Avenue, Suite 7

Pharmaceutical Products Division

Abbott Park IL 60064

9610 Medical Center Drive

Copiaque NY 11726-0030

Centocor, Inc. Malvern PA 19355

Ericsson, Arthur Dale, M.D. Houston TX 77303

Ferring Laboratories, Inc. Suffern NY 10901

Fleischmann, Jonathan M.D. 3395 Scranton Road

University of Arizona Tucson AZ 85723

One Health Plaza

YM Biosciences Inc. 5045 Orbitor Drive CANADA

Xechem International, Inc. 379 Thornall Street Edison NJ 08837

Romark Laboratories, L.C. Suite 880

Swedish Orphan AB Kungsgatan 37, 7th Floor SE-111 56 SWEDEN

INO Therapeutics 6 Route 173 Clinton NJ 08809

SensorMedics Corporation

INO Therapeutics 6 Route 173 Clinton NJ 08809

INO Therapeutics, Inc. 54 Old Highway 22 Clinton NJ 08809

200 Great Valley Parkway

6560 Fannin, Scurlock Tower, Suite 720

400 Rella Boulevard, Suite 201

MetroHealth Medical Center

Cleveland OH 44109

Valley Fever Center for Excellence (1-111 INF)

Novartis Pharmaeuticals Corporation

East Hanover NJ 07936-1080

Mississauga, Ontario L4W 4Y4

6200 Courtney Campbell Causeway

Tampa FL 33607

22705 Savi Ranch Parkway

Yorba Linda CA 92887-4645

Thomas, MD, Jeffrey Evan

45 Hartwell Ave. Lexington MA 02421

Pfizer, Inc. La Jolla Laboratories

Nuvelo, Inc. Inc. 201 Industrial Road Suite 310

Antisoma Research Ltd. Hanger Lane Ealing UNITED KINGDOM

Antisoma Research Ltd. Hanger Lane Ealing, London UNITED KINGDOM

800 Research Parkway Suite 200

Gemin X, Inc. 5 Great Valley Parkway Malvern PA 19355

Gemin X, Inc. 5 Great Valley Parkway Malvern PA 19355

400 Chesterfield Pkwy. Suite 100

Genta Inc. Two Connell Drive

Genta, Inc. Two Connell Drive

Genta, Inc, Two Connell Drive

Genta, Inc. Two Connell Drive

GlaxoSmithKline One Franklin Plaza Phildelphia PA 19101

Thomas Jefferson University and Wills Neurosensory

834 Walnut Street, Suite 650

Philadelphia PA 19107-5102

Synta Pharmaceuticals Corporation

10646 Science Center Drive

San Diego CA 92121

San Carlos CA 94070-

Novazyme Pharmaceuticals, Inc.

Oklahoma City OK 73104

Gemin X Pharmaceuticals US, Inc.

Malvern PA 19355

Berkeley Heights NJ 07922

Berkeley Heights NJ 07922

Berkeley Heights NJ 07922

Berkeley Heights NJ 07922

Implicit Bioscience Pty Ltd P. O. Box 2072 Toowong Business Center AUSTRALIA

Omex International, Inc. 6001 Savoy, Suite 110 Houston TX 77036

3715 Haven Avenue Menlo Park CA 94025

3715 Haven Avenue Menlo Park CA 94025

Durham NC 27713

Pronova Biocare, AS PO Box 420 1327 Lysaker NORWAY

Daimlerstrasse 16 GERMANY

Hammerstrasse 47 SWITZERLAND

Antigenics, Inc. 3 Forbes Road Lexington MA 02421

Cytogen Corporation 600 College Road East Princeton NJ 08540

TRF Technologies, Inc. Burlingame CA 94010

Oxis International, Inc. Portland OR 97217-3935

Debio Pharm S.A. Rue des Terreaux 17 CH-1000 SWITZERLAND

OxThera, Inc. 13709 Progress Blvd. #17 Alachua FL 32615

Bio-Technology General Corp. 70 Wood Avenue, South Iselin NJ 08830

ChemGenex Pharmaceuticals, Inc.

ChemGenex Pharmaceuticals, Inc.

Research Triangle Pharmaceuticals

4364 South Alston Avenue

Fresenius Kabi Deutschland GmbH

Santhera Pharmaceuticals Limited

863 Mitten Road, Suite 101

6040 N. Cutter Circle, Suite 317

Bio-Technology General Corp. 70 Wood Avenue, South Iselin NJ 08830

Savient Pharmaceuticals, Inc. East Brunswick NJ 08816

Bio-Technology General Corp. East Brunswick NJ 08816

Bio-Technology General Corp. 70 Wood Avenue South Iselin NJ 08830

P.O. Box 80027 Wilmington DE 19880

Cardiome Pharma Corp. 3650 Westbrook Mall Vancouver, B.C. CANADA

Inspire Pharmaceuticals, Inc. 4222 Emperor Blvd. Suite 470

Inspire Pharmaceuticals, Inc. Durham NC 27703

MediGene AG Lochhamer Str. 11 GERMANY

4400 Biscayne Boulevard Miami FL 33137

Protherics, Inc. 5214 Maryland Way Suite 405

Protherics, Inc. 5214 Maryland Way Brentwood TN 37027

Oasmia Pharmaceutical AB Vallongatan Uppsala SWEDEN

Immtech Pharmaceuticals, Inc. 150 Fairway Drive Vernon Hills IL 60061

One Tower Center Boulevard, 12th floor

One Tower Center Boulevard, 12 th floor

DuPont Merck Pharmaceutical Company

Durham NC 27703

4222 Emperor Blvd., Suite 470

Baker Norton Pharmaceuticals, Inc.

Brentwood TN 37027

Immtech Pharmaceuticsl, Inc. 150 Fairway Drive Vernon Hills IL 60061

Immtech Pharmaceuticals, Inc. 150 Fairway Drive Suite 150

Ziopharm Oncology, Inc. Boston MA 02129

One Health Plaza

Marlyn Nutraceuticals, Inc. 14851 N. Scottsdale Rd. Scottsdale AZ 85254

NPS Pharmaceuticals, Inc. 300 Interpace Parkway Parsippany NJ 07054

Office of the Surgeon General Department of the Army 1430 Veteran's Drive

MedImmune, Inc. 35 West Watkins Mill Rd. Gaithersburg MD 20878

Ear Foundation Santa Barbara CA 93105

One Health Plaza

49 Convent Dr. MSC4405 Bldg. 49, Room B1EE16

Hoffman-La Roche Inc. 340 Kingsland St. Nutley NJ 07110-1199

Hoffman-La Roche Inc. 340 Kingsland St. Nutley NJ 07110-1199

Schering-Plough Corporation 2000 Galloping Hill Road Kenilworth NJ 07933-0530

Chiron Corporation 4560 Horton Street Emeryville CA 94608

Vernon Hills IL 60061

One First Avenue, Parris Building 34

Novartis Pharmaceuticals Corporation

East Hanover NJ 07936-1080

Ft. Detrick MD 21702

2420 Castillo Street, Suite 100

Novartis Pharmaceutical Corporation

East Hanover NJ 07936-1080

National Institute of Mental Health, NIH

Bethesda MD 20892-4405

Polaris Pharmaceuticals, Inc. Suite 106

Polaris Pharmaceuticals, Inc. 6370 Nancy Ridge Drive

Amgen, Inc. One Amgen Center Dr.

BioCryst Pharmaceuticals, Inc. 2190 Parkway Lake Drive Birmingham AL 35244

Aventis Behring L.L.C. 1020 First Avenue PO Box 61501

Fisons Corporation Rochester NY 14603

Goerzallee 253 GERMANY

TRF Pharma, Inc. 863 Mitten Road Burlingame CA 94010

SuperGen, Inc. 4140 Dublin Blvd. Suite 200

SuperGen, Inc. 4140 Dublin Blvd. Suite 200

SuperGen, Inc. 4140 Dublin Blvd. Suite 200

Digna Biotech, S.L. Pamplona (Navarra) SPAIN

Digna Biotech, S.L. SPAIN

Ardana Bioscience Ltd. 38 Melville Street Scotland UNITED KINGDOM

A Polaris Group Company

San Diego CA 92121

A Polaris Group Company

San Diego CA 92121

Thousand Oaks CA 91320-1789

King of Prussia PA 19406-0901

755 Jefferson Rd., P.O. Box 1710

Heyl Chemisch-Pharmazeutische Fabrik GMBH & Co. KG

Fedderal of Republic of Germany

Dublin CA 94568

Dublin CA 94568

Dublin CA 94568

Avenida Carlos III el Noble

Avenida Carlos III el Noble, 36, 1 Dcha. 31003

Alliance Pharmaceutical Corp. 3040 Science Park Road San Diego CA 92191

Scios Nova, Inc. 2450 Bayshore Parkway Mountain View CA 94043

Sallee, Floyd R. M.D., Ph.D. 3333 Burnet Ave.

Elan Drug Delivery, Inc. 1300 Gould Dr. Gainesville GA 30504

Biomarin Pharmaceutical 105 Digital Drive Novato CA 94949

Elan Drug Delivery, Inc. 1300 Gould Dr. Gainesville GA 30504

S.L.A. Pharma Leavesden, Watford UNITED KINGDOM

Medea Research Laboratories

1730 Michael Lane

Isis Pharmaceuticals, Inc. 1896 Rutherford Road Carlsbad CA 92008

Poniard Pharmaceuticals 300 Elliott Avenue West Seattle WA 98119

UCB Pharma, Inc. 1950 Lake Park Drive Smyrna GA 30080

Burroughs Wellcome Company 3030 Cornwallis Road P.O. Box 12700

Copernicus Therapeutics, Inc. 11000 Cedar Avenue Cleveland OH 44106

Cincinnati Children's Hospital Medical Center

Cincinnati OH 45229-3039

Unit 3, Hill Farm Industrial Estate

Port Jefferson Business Center

200 Wilson Street, Building D-6

Port Jefferson NY 11776

The Cure Our Children Foundation

Pacific Palisades CA 90272-2037

Research Triangle Park NC 27709

Talecris Biotherapeutics, Inc. 8368 US 70 West Clayton NC 27520

BTG International, Ltd 10 Fleet Place London EC4M 7SB UNITED KINGDOM

BTG International Ltd 10 Fleet Place London EC4M 7SB UNITED KINGDOM

PharmaMar USA, Inc University Park at M.I.T. The Richards Building 64

PharmaMar USA, Inc. University Park at M.I.T. The Rishards Building

CytRx Corporation 154 Technology Parkway Norcross GA 30092

SynthRx Corporation 4606 Willow Bellaire TX 77401

CytRx Corporation 154 Technology Parkway Norcross GA 30092

CytRx Corporation 154 Technology Parkway Norcross GA 30092

Hemispherx Biopharma, Inc. One Penn Center 1617 JFK Boulevard

Hemispherx Biopharma, Inc. One Penn Center 1617 JFK Boulevard

Hemispherx Biopharma, Inc. One Penn Center 1617 JFK Boulevard

Hemispherx Biopharma, Inc. One Penn Center 1617 JFK Boulevard

Savient Pharmaceuticals, Inc. East Brunswick NJ 08816

Cambridge MA 02139-4170Cambridge MA 02139-4170

Philadelphia PA 19103

Philadelphia PA 19103

Philadelphia PA 19103

Philadelphia PA 19103

One Tower Center Boulevard, 14th floor

EnzymeRx, LLC 17 Arcadian Avenue Suite 104

EnzymeRx, LLC 17 Arcadian Avenue Suite 104

EnzymeRx, LLC 17 Arcadian Avenue Suite 104

Oncovir Washington DC 20008

Oncovir 3203 Cleveland Ave., NW

Oncovir 3203 Cleveland Ave., NW

Oncovir 3203 Cleveland Ave., NW

Capmed USA P.O. Box 14 Bryn Mawr PA 19010

Polyphenon E International, Inc. 655 Third Avenue New York NY 10017

Polynoma LLC San Diego CA 92130

Diacrin/Genzyme LLC One Kendall Square

Diacrin/Genzyme LLC One Kendall Square

Diacrin/Genzyme LLC One Kendall Square

Diacrin/Genzyme LLC One Kendall Square

Titan Pharmaceuticals, Inc. Post Office Plaza

Paramus NJ 07652

Paramus NJ 07652

Paramus NJ 07652

3202 Cleveland Avenue N.W.

Washington DC 20008-3450

Washington DC 20008-3450

Washington DC 20008-3450

11622 El Camino Real #100

Cambridge MA 02139-1562

Cambridge MA 02139-1562

Cambridge MA 02129-1562

Cambridge MA 02139-1562

50 Division Street, Suite 503

Somerville NJ 08876

Axcan Scandipharm Inc. 22 Inverness Parkway Birmingham AL 35242

QLT Phototherapeutics, Inc. Lederle Laboratories

900 Ridgebury Road PO Box 368

900 Ridgebury Road PO Box 368

Schering-Plough Corporation 2000 Galloping Hill Road Kenilwortoh NJ 07033

Willen Drug Company

Framework Therapeutics, LLC 1564 33rd Street, NW Washington DC 20007

The Vaccine Company P. O. Box 93921 Carmel CA 93921

The Vaccine Company P. O. Box 93921 Carmel CA 93921

The Vaccine Company P. O. Box 93921 Carmel CA 93921

Pharmos 2 Innovation Drive Alachua FL 32615

Pharmos 2 Innovation Drive Alachua FL 32615

Pharmos 2 Innovation Drive Alachua FL 32615

Pharmos 2 Innovation Drive Alachua FL 32615

401 North Middletown Road

Pearl River NY 10965

Boehringer Ingelheim Pharmaceuticals, Inc.

Ridgefield CT 06877

Boehringer Ingelheim Pharmaceuticals, Inc.

Ridgefield CT 06877

Allos Therapeutics, Inc. 11080 CirclePoint Road Westminster CO 80020

Allos Therapeutics, Inc. Westminister CO 80020

Allos Therapeutics, Inc. 11080 CirclePoint Road Suite 200

900 Ridgebury Road Ridgefield CT 06877

Cambridge Neuroscience, Inc. Cambridge MA 02139

EM Pharmaceuticals, Inc.

Pharmacia Inc. P.O. Box 16529

Sanofi Winthrop, Inc. 90 Park Avenue New York NY 10016

9841 Washingtonian Blvd Suite 500

Watson Laboratories, Inc. 311 Bonnie Circle Corona CA 91720

Bausch & Lomb Pharmaceuticals Division

Pierre Fabre Dermatologie Les-Cauquillous FRANCE

LTT Baio-Pharma Co., Ltd JAPAN

Alpha Therapeutic Corporation 5555 Valley Boulevard Los Angeles CA 90032

11080 Circle Point Road, Suite 200

Westminster CO 80020

Boehringer-Ingelheim Pharmaceuticals, Inc.

1 Kendall Square, Bldg. 700

Columbus OH 43216-6529

Sigma-Tau Pharmaceuticals, Inc.

Gaithersburg MD 20878

8500 Hidden River Parkway

Tampa FL 33637

Research & Development Division

2-5-1 Atago, Minato-ku, Tokyo

Biophysica, Inc. 2159 Avenida de la Playa Suite B

New York NY 10022

New York NY 10022

UCB Pharma, Inc. 1950 Lake Park Drive Smyrna GA 30080

Abbott Laboratories 200 Abbott Park Road Abbott Park IL

Scios Nova, Inc. 2450 Bayshore Parkway Mountain View CA 94043

ImmuneWorks, Inc. 351 West 10th Street Indianapolis IN 46202

Able Laboratories, Inc. 200 Highland Avenue Suite 30

AutoImmune, Inc. 128 Spring Street Lexington MA 02421

Cellular Sciences, Inc 84 park Avenue P.O. Box 968

Lyphomed, Inc.

Zydus Pharmaceuticals, Inc. 210 Carnegie Center Princeton NJ 08540

Ascenta Therapeutics, Inc. 101 Lindenwood Drive Suite 405

Seaside Therapeutics, Inc. 840 Memorial Drive Cambridge MA 02139

11801 Research Drive Suite D

La Jolla CA 92037

Immuno Clinical Research Corp.

750 Lexington Avenue, 19th Floor

Immuno Clinical Research Corp.

750 Lexington Avenue, 19th Floor

Needham MA 02494

Flemington NJ 08822

Malvern PA 19355

Applied Genetic Technologies Corp.

Alachua FL 32615

Children's Hospital of Pittsburgh University of Pittsburgh Pittsburgh PA 15213

Alfacell Corporation 225 Belleville Ave. Bloomfield NJ 07003

OncoImmune, Inc. 4532 Benderton Court Columbus OH 43220

ARIAD Pharmaceuticals, Incx. 26 Landsdowne Street

Human Genome Sciences, Inc. 14200 Shady Grove Road Rockville MD 20850

12085 Research Drive Suite 110

MedImmune, LLC One MedImmune Way Gaithersburg MD 20878

MedImmune, LLC One MedImmune Way Gaithersburg MD 20878

Oncology Business Unit One Health Plaza

Oncology Business Unit One Health Plaza

Xoma (US) LLC 2910 Seventh Street Berkeley CA 94710

Elusys Therapeutics, Inc. 25 Riverside Drive P.O. Box 102

PharmaOrigin ApS Scion DTU Boge alle 5, 1.tv DENMARK

Alseres Pharmaceuticals, Inc. 85 Main Street Hopkinton MA 01748

Cambridge MA 02139-4234

Applied Genetic Technologies Corp.

Alachua FL 32615

Novartis Pharmaceutical Corporation

East Hanover NJ 07986

Novartis Pharmaceutical Corporation

East Hanover NJ 07936

Pine Brook NJ 07058

Baxter Healthcare Corporation Baxter Bioscience

Baxter Healthcare Corporation Baxter Bioscience

Henogen S.A. B-6041-Gosselies BELGIUM

PharmAthene, Inc. One Park Place Suite 450

Viventia Biotech, Inc. 10 Four Seasons Place CANADA

NPS Allelix Corp. 6850 Goreway Dr. Ontario L4V 1V7 CANADA

Arriva Pharmaceuticals, Inc. 1010 Atlantic Avenue Alameda CA 94501

Arriva Pharmaceuticals, Inc. 2020 Challenger Drive Alameda CA 94501

Roslin, Edinburgh EH259PP Scotland UNITED KINGDOM

Arriva Pharmaceuticals, Inc. 1010 Atlantic Avenue Alameda CA 94501

101 Binney Street Cambridge MA 02142

Zymenex A/S Roskildevej 12 C DENMARK

Wyeth Pharmaceuticals, Inc. P. O. Box 8299

AT III LLC c/o Genzyme Corporation

700 Main Street Cambridge MA 02139

Westlake Village CA 91362

Westlake Village CA 91362

Rue des Professeurs Jenner et Brachet, 12

Annapolis MD 21401

Toronto ON M9B 6H7

PPL Therapeutics (Scotland) Limited

Merrimack Pharmaceuticals, Inc.

Philadelphia PA 19101-8299

15 Pleasant St. Connector, P.O. Box 9322

Framingham MA 01701

Shire Human Genetic Therapies

Pharming Technologies B.V. Archimedesweg 4 NETHERLANDS

Pharming Technologies B.V. Archimedesweg 4 NETHERLANDS

Pharming N.V. Cipalstreet 3 B-2440 Geel BELGIUM

Pharming N.V. Cipalstreet 3 B-2440 Geel BELGIUM

Genentech, Inc.

CC10 Sweden AB Kornhamnstorg 53 Box 2077 SWEDEN

Syntonix Pharmaceuticals Waltham MA 02451

EntreMed, Inc. Rockville MD 20850

EntreMed, Inc. Rockville MD 20850

Pharming Technologies B.V. Archimedesweg 4 NETHERLANDS

CuraGen Corporation 322 East Main Street Branford CT 06405

Biogen, Inc. 14 Cambridge Center Cambridge MA 02142

Biogen, Inc. 14 Cambridge Center Cambridge MA 02124

Nora Therapeutics, Inc. 2400 Boston Street Baltimore MD 21224

800 Research Parkway Suite 200

460 Point San Bruno Boulevard

South San Francisco CA 94080

A Subsidiary of Biogen Idec

9640 Medical Center Drive

9640 Medical Center Drive

Novazyme Pharmaceuticals, Inc.

Oklahoma City OK 73104

SymbioTec GmbH Sciene Park Saar 1 Saarbruecken GERMANY

Pharmacia & Upjohn 7000 Portage Road

Pharmacia & Upjohn 7000 Portage Road

GroPep Pty Ltd. Gate 11, Victoria Dr. Adelaide SA 5000 AUSTRALIA

Cephalon, Inc. 41 Moores Road P. O. Box 4011

Insmed, Inc. Suite 200

Genetics Institute, Inc. 87 CambridgePark Drive Cambridge MA 02140

Zymo Genetics, Inc Seattle WA 98102

Amgen Inc. One Amgen Center Dr.

Lysosomal Acid Lipase, LLC 3700 Airpark Drive

ThromboGenics Ltd Dublin IRELAND

Adienne S.r.1. 24128 Bergamo 64/B Boseta Street ITALY

Adienne S.r.1. ITALY

Novartis Pharmaceuticals Corp. One Health Plaza UNITED KINGDOM

Kalamazoo MI 49001-0199

Kalamazoo MI 49001-0199

Frazer PA 19355

8720 Stony Point Parkway

Glen Allen VA 23235-

1201 Eastlake Avenue East

Thousand Oaks CA 91320-1799

Subsidiary of Kentucky BioProcessing, LLC

Owensboro KY 42301

Unit 14, Bridgecourt Office Park

24128 Bergamo, 64/B Broseta Street

East Hanover NJ 07936-1080

Genentech, Inc. 1 DNA Way

Dyax Corporation 300 Technology Square Cambridge MA 02139

Luitpold Pharmaceuticals, Inc. P. O. Box 9001 One Luitpold Drive

Zymenex A/S Roskildevej 12C 3400 Hillerod DENMARK

ZymenexA/S Roskildevej 12C 3400 Hillerod DENMARK

ProRetina Therapeutics, S.L. 28224 Pozuelo de Alarcon SPAIN

Connetics Corporation Palo Alto CA 94303

Fovea Pharmaceuticals Paris FRANCE

Genentech, Inc. 1 DNA Way

Proteon Therapeutics, Inc. 200 West Street Waltham MA 02451

1303 North Mission Road

Biogen, Inc. 14 Cambridge Center Cambridge MA 02142

Biogen, Inc. 14 Cambridge Center Cambridge MA 02142

Biogen, Inc. 14 Cambridge Center Cambridge MA 02142

South San Francisco CA 94080

Shirley NY 11967

Centro de Empresas de Pozuelo

3400 West Bayshore Road

12 Rue Jean Antoine de Baif

South San Francisco CA 94080-4990

David T. Woodley, MD and Mei Chen, MD

USC Department of Dermatology, Cancer Research Lab

Los Angeles CA 90033

Biogen, Inc. 14 Cambridge Center Cambridge MA 02142

Biogen, Inc. 14 Cambridge Center Cambridge MA 02142

Amgen, Inc. One Amgen Center Dr.

PEPGEN Corporation Alameda CA 94502

Ipsen Limited 190 Bath Road Berkshire S11 3XE UNITED KINGDOM

Y's Therapeutics, Inc. 1111 Bayhill Drive Suite 405

Y's Therapeutics, Inc. 866 Malcolm Road Burlingame CA 94010

Genetic Therapy, Inc. 938 Clopper Road Gaithersburg MD 20878

Amgen, Inc. 3200 Walnut Street Boulder CO 80301

Amgen Inc. 3200 Walnut Street Boulder CO 80301

Biogen, Inc. 14 Cambridge Center Cambridge MA 02142

Genentech, Inc.

Suite 450

Aerovance, Inc. 2929 Seventh Street Berkeley CA 94710

Thousand Oaks CA 91320-1799

1301 Harbor Bay Parkway

San Bruno CA 94066-3002

460 Point San Bruno Boulevard

South San Francisco CA 94080

Artielle ImmunoTherapeutics, Inc.

9020 SW Washington Square Road

Tigard, OR 97223-4332

Sanofi-Synthelabo Research 9 Great Valley Parkway Malvern PA 19355

146 Flanders Drive Hillsborough NJ 08876

AstraZeneca LP 725 Chesterbrook Blvd. Wayne PA 19087-5677

Dompe s.p.a. Via Campo di Pile 67100 - L'Aquila ITALY

Questcor Pharmaceuticals, Inc. 3260 Whipple Road

NIH/NIDCR 10 Convent Drive

Ception Therapeutics, Inc. 101 Lindenwood Drive Suite 400, Valleybrook III

MedImmune, Inc. Gaithersburg MD 20878

Infinity Pharmaceuticals, Inc. 780 Memorial Drive Cambridge MA 02139

P. O. Box 8355 1800 Concord Pike

Cephalon, Inc. 41 Moores Road Frazer PA 19355

AVAX technologies, Inc. Building 9, Suite 200

Genzyme Corporation One Mountain Road P.O. Box 9322

Abbott 200 Abbott Park Rd.

Abbott 200 Abbott Park Rd.

Telluride Pharmaceutical Corporation

Union City CA 94587-1217

Bldg 10/Rm 2N236 - DASS/CC

Bethesda MD 20892

Malvern PA 19335

35 West Watkins Mill Road

AstraZeneca Pharmaceuticals LP

Wilmington DE 19803-8355

9200 Indian Creek Parkway

Overland Park KS 66210

Framingham MA 01701-9322

Abbott Laboratories, Dept. 389, Bldg. J-45

Abbott Park IL 60064-6135

Abbott Laboratories, Dept. 389, Bldg. J-45

Abbott Park IL 60064-6133

Targeted Genetics Corporation Seattle WA 98101

Insmed Inc. 4851 Lake Brooke Drive Glen Allen VA 23060

ThromboGenics Inc. Unit 14 Walkinstown Avenue Dublin 12 IRELAND

3300 Hyland Avenue Costa Mesa CA 92626

ImmunoGen, Inc. 148 Sidney Street Cambridge MA 02139

ImmunoGen, Inc. 148 Sidney Street Cambridge MA 02139

ImmunoGen, Inc. 148 Sidney Street Cambridge MA 02139

ImmunoGen, Inc. 148 Sidney Street Cambridge MA 02139

ImmunoGen, Inc. 148 Sidney Street Cambridge MA 02139

ImmunoGen, Inc. 148 Sidney Street Cambridge MA 02139

Pfizer, Inc. 235 East 42nd Street New York NY 10017

PathoGenesis Corporation 201 Elliott Avenue West Suite 150

Hoechst Marion Roussel, Inc. P.O. Box 9627 Mail Station: H3-M2516

Hoechst Marion Roussel , Inc. P.O. Box 9627 Mail Station: H3-M2516

Salix Pharmaceuticals, Inc. Morrisville NC 27560

1100 Olive Way, Suite 100

Valeant Pharmaceuticals International

Seattle WA 98119 Kansas City MO 64134-0627

Kansas City MO 64134-0627

1700 Perimeter Park Drive

Sparta Pharmaceuticals, Inc. 111 Rock Road Horsham PA 19044-2310

500 Arcola Road PO Box 5096

Mason OH 08807

Genentech, Inc. 1 DNA Way

Genentech, Inc. 1 DNA Way

Genentech, Inc. 1DNA Way MS 241A

AVI BioPharma, Inc. One SW Columbia Street Portland OR 97258

MERCK & Co., Inc. 126 East Lincoln Ave. Rahway NJ 07065

One Broadway Cambridge MA 02142

Pharmacia & Upjohn 7000 Portage Road

Provectus Pharmaceuticals, Inc. 7327 Oak Ridge Highway Knoxville TN 37931

Byk Gulden Pharmaceuticals Byk-Gulden StraBe 2 78467 Konstanz GERMANY

Altana Pharma 220 Park avenue Florham Park NJ 07932

SuperGen, Inc. 4140 Dublin Blvd. Suite 200

EntreMed Incorporated 9640 Medical Center Dr. Rockville MD 20850

Rhone-Poulenc Rorer Pharmaceuticals, Inc.

Collegeville PA 19426-0800

Proctor and Gamble Pharmaceuticals

8700 Mason-Montgomery Road

South San Francisco CA 94080-4990

South San Francisco CA 94080-4990

South San Francisco CA 94080

Gloucester Pharmaceuticals, Inc.

Kalamazoo MI 49001-0199

Dublin CA 94568

Genopia USA, Inc. 90 Gold Street, 6N New York NY 10038

Sunrise FL 33323

Phytopharm plc Corpus Christi House UNITED KINGDOM

1250 S. Collegeville Road

Debiovision Inc. Montreal, Quebec

Schering Corporation 2000 Galloping Hill Rd. Kenilworth NJ 07033

Suite 405 CANADA

Teva Pharmaceuticals USA 650 Cathill Rd. Sellersville PA 18960

Synergen, Inc. 1885 33rd Street Boulder CO 80301

Neotropix, Inc. 351 Phoenixville Pike Malvern PA 19355

EMD Serono, Inc. One Technology Place Rockland MA 02370

EMD Serono, Inc. One Technology Place Rockland MA 02370

Cell Technology, Inc. 1668 Valtec Lane Boulder CO 80306

Seattle Genetics, Inc. Bothell WA 98021

Seattle Genetics, Inc Bothell WA 98021

Seattle Genetics, Inc. Bothell WA 98021

Concordia Pharmaceuticals, Inc.

1550 Sawgrass Corporate Parkway

Godmanchester, Cambridgeshire PE29 2HY

SmithKline Beecham Pharmaceuticals

Collegeville PA 19426-0989

666 Sherbrooke Street West, Suite 1400

Chemokine Therapeutics Corporation

190 Agronomy Road (UBC)

Vancouver, BC V6T 1Z3

21823 30th Drive Southeast

21823 30th Drive, Southeast

21823 30th Drive Southeast

Seattle Genetics, Inc. Bothell WA 98021

Richard I. Breuer, M.D. Evanston IL 60201

Richard I. Breuer Evanston IL 60201

Synthes (USA) 1690 Russell Road PO Box 1766

MedImmune, LLC One MedImmune Way Gaithersburg 20878

New London CT 06320

One Franklin Plaza Philadelphia PA 19101

101 Federal Street Boston MA 02110

40 Landsdowne Street Cambridge MA 02139

Framework Therapeutics, LLc 1564 33rd Street, NW Washington DC 20007

IC-MedTech Corporation 9902 Indian Creek Lane El Cajon CA 92021

Stacpoole, Peter W. M.D., Ph.D. University of Florida P.O. Box 100277

Stacpoole, Peter W. M.D., Ph.D. University of Florida P.O. Box 100277

Questcor Pharmaceuticals, Inc. 3260 Whipple Rd.

21823 30th Drive Southeast

1000 Central Street, Suite 615

1000 Central Street, Suite 615

Paoli PA 19301

Pfizer Global Research and Development

50 Pequot Avenue 6025-B4137

SmithKline Beecham Pharmaceuticals

HemaQuest Pharmaceuticals, Inc.

Millennium Pharmaceuticals, Inc.

Gainesville FL 32610

Gainesville FL 32610

Union City CA 94587-1217

Stacpoole, Peter W. M.D., Ph.D. University Of Florida P.O. Box 100277

EBD Group 2032 Corte del Nogal Suite 120

Questcor Pharmaceuticals, Inc. 3260 Whipple Rd.

Boise ID 83702

Theragenics Corporation

Hope Pharmaceuticals, Inc Scottsdale AZ 85260

Hope Pharmaceuticals 8260 East Gelding Drive Scottsdale AZ 85260

Hope Pharmaceuticals 8260 E. Gelding Drive Scottsdale AZ 85260

Aires Pharmaceuticals, Inc. 4690 Executive Drive Suite 150

Hope Pharmaceuticals 8260 E. Gelding Drive Scottsdale AZ 85260

Keystone Pharmaceuticals, Inc. 26072 Merit Circle Laguna Hills CA 92653

Ucyclyd Pharma, Inc. 8125 North Hayden Road Scottsdaale AZ 85258

Tikvah Therapeutics, Inc. 75 5th Street, NW. Atlanta GA 30308

Ucyclyd Pharma, Inc. 8125 N. Hayden Road Scottsdale AZ 85258

Gainesville FL 32610

Carlsbad CA 92011

Union City CA 94587-0700

Neutron Technology Corp.& Neutron R&D Partner

877 Main Street, Suite 402

8260 E. Gelding Drive #104

San Diego CA 92121

Elan Drug Delivery, Inc. 1300 Gould Dr. Gainesville GA 30504

Medicis Pharmaceutical Corp. 8125 N. Hayden Road Scottsdale AZ 85258

Cellular Sciences, Inc. 84 Park Avenue P. O. Box 968

VioQuest Pharmaceuticals, Inc. 180 Mt. Airy Road Suite 102

Adherex Technologies, Inc. 4620 Creekstone Drive Suite 200

Akorn, Inc. 2500 Millbrook Drive Buffalo Grove IL 60089

Keystone Pharmaceuticals, Inc. 26072 Merit Circle Laguna Hills CA 92653

Solbec Pharmaceuticals Limited P. O. Box 2142 WA 6018 AUSTRALIA

Solbec Pharmaceuticals Limited P. O. Box 2142 AUSTRALIA

Avant Immunotherapeutics, Inc. 119 Fourth Ave. Needham MA 02494-2725

T Cell Sciences, Inc. 119 Fourth Avenue

Octapharma USA, Inc. 121 River Street 12th Floor

Ferring Laboratories, Inc. Suffern NY 10901

UCB, Inc. 1950 Lake Park Drive Smyrna GA 30080

Genentech, Inc.

Flemington NJ 08822

Basking Ridge NJ 07920

Durham NC 27703

Osbourne Park, Western Australia 6017

Needham Heights MA 02194

Hoboken NJ 07030

400 Rella Boulevard, Suite 201

460 Point San Bruno Boulevard

South San Francisco CA 94080

Eli Lilly and Company Lilly Corporate Center Indianapolis IN 46285

Novo Nordisk Pharmaceuticals 100 Overlook Center Suite 200

Novo Nordisk Pharmaceuticals 100 Overlook Center Suite 200

Bio-Technology General Corp. 70 Wood Avenue, South Iselin NJ 08830

EMD Serono, Inc. One Technology Place Rockland MA 02370

EMD Serono, Inc. One Technology Place Rockland MA 02370

EMD Serono, Inc. One Technology Place Rockland MA 02370

Bayer Pharmaceuticals Corp. 400 Morgan Lane New Haven CT 06516

Bristol-Myers Squibb 5 Research Parkway P.O. Box 5100

Berlex Laboratories, Inc. 300 Fairfield Road Wayne NJ 07470

Ocera Therapeutics, Inc. 12651 High Bluff Drive San Diego CA 92130

500 Arcola Road Collegeville PA 19426

Genaera Corporation 5110 Campus Drive

National Institutes of Health Suite 7111

National Institutes of Health NCI/DCTD

Princeton NJ 08540

Princeton NJ 08540

Wallingford CT 06492

Rhone-Poulenc Rorer Pharmaceuticals

Plymouth Meeting PA 19462

Cancer Therapy Evaluation Program/DCTD/NCI

Rockville MD 20852

Cancer Therapy Evaluation Program

Rockville MD 20852

Sanofi Winthrop, Inc. 9 Great Valley Parkway Malvern PA 19355

Sanofi Winthrop, Inc. 9 Great Valley Parkway Malvern PA 19355

Boca Raton FL 33487

Gamida Cell Ltd 5, Nahum Hafzadi St. Jerusalem 95484 ISRAEL

Novatech SA 13685 Aubagne FRANCE

Novatech SA 13685 Aubagne FRANCE

Biocodex 7, avenue Gallieni 94250 Gentilly FRANCE

Sugen, Inc. 230 East Grand Ave.

Sugen, Inc. 230 East Grand Ave.

Sanofi Winthrop, Inc. 90 Park Avenue New York NY 10016-1389

Sanofi Winthrop, Inc. 90 Park Avenue New York NY 10016-1389

Fuisz Technologies, Ltd. 14555 Avion at Lakeside Chantilly VA 20151

Darby Pharmaceuticals, Inc. 100 Banks Avenue

Biotest Pharmaceuticals Corporation

5800 Park of Commerce Blvd, NW

Avenue du Vent des Dames - Z.l. les Paluds

Avenue du Vent des Dames - Z.l. les Paluds

South San Francisco CA 94080-4811

South San Francisco CA 94080-4811

Rockville Centre NY 11570

Darby Pharmaceuticals, Inc. 100 Banks Avenue

700 Main Street Cambridge MA 02139

37 Cleveland Lane P.O. Box 5290

Pharmacia-Chiron Partnership 4560 Horton Street Emeryville CA 94608

Bio-Technology General Corp. 70 Wood Avenue, South Iselin NJ 08830

Warner-Lambert Company 2800 Plymouth Road

Merritt, T. Allen M.D. 2516 Stockton Boulevard Sacramento CA 95817

Synsorb Biotech Inc. Calgary, Alberta CANADA

Rare Disease Therapeutics, Inc. 2550 Meridian Blvd Nashville TN 37217

Repligen Corporation 41 Seyon Street Waltham MA 02453

ChiRhoClin, Inc. 15500 Gallaudet Ave.

ChiRhoClin, Inc. 15500 Gallaudet Ave.

ChiRhoClin, Inc. 15500 Gallaudet Ave.

ChiRhoClin, Inc. 1550 Gallaudet Ave.

Rockville Centre NY 11570

Shire Human Genetic Therapies, Inc.

Jacobus Pharmaceutical Company

Princeton NJ 08540

Parke-Davis Pharmaceutical Research Division

Ann Arbor MI 48105-2430

201, 1204 Kensington Road, N.W.

Silver Spring MD 20905-4176

Silver Spring MD 20905-4176

Silver Spring MD 20905-4176

Silver Spring MD 20905-4176

ChiRhoClin, Inc. 15500 Gallaudet Ave.

AGI Dermatics 205 Buffalo Avenue Freeport NY 11520

Fujisawa USA, Inc. 3 Parkway North Center Deerfield IL 60015

Eli Lilly and Company Lilly Corporate Center Indianapolis IN 46285

Tap Holdings Inc. 2355 Waukegan Road Deerfield IL 60015

Agennix, Inc. 8 Greenway Plaza Houston TX 77046

Agennix, Inc. 8 Greenway Plaza Suite 910

Agennix, Inc. Greenway Plaza Suite 910

Agennix, Inc. 8 Greenway Plaza Suite 910

TEVA Neuroscience, Inc. 425 Privet Road Horsham PA 19044-8005

TEVA Neuroscience P. O. Box 1005 Horsham PA 19044-8005

CytRx Corporation 3030 Bunker Hill Road Suite 101

Bristol-Myers Squibb 5 Research Parkway

Nexell Therapeutics Inc. 9 Parker Irvine CA 92618-1605

Silver Spring MD 20905-4176

Houston TX 77046

Houston TX 77046

Houston TX 77046

San Diego CA 92109

research and Development

Wallingford CT 06492-7660

TransDerm, Inc. 2161 Delaware Aenue Santa Cruz CA 95060

Endocyte, Inc. 1205 Kent Ave. West Lafayette IN 47906

NeoRx Corporation 410 West Harrison Seattle WA 98119-4007

Immunomedics, Inc. 300 American Road Morris Plains NJ 07950

Immunomedics, Inc. 300 American Road Morris Plains NJ 07950

Immunomedics, Inc. 300 American Road Morris Plains NJ 07950

Immunomedics, Inc. 300 American Road Morris Plains NJ 07950

Theseus Imaging Corporation 124 Mount Auburn Street Suite 200 North

Taiho Pharma USA, Inc. 210 Carnegie Center Princeton NJ 08540

Belpharma N.V. Brussels BELGIUM

Biolitec Pharma Ireland Ltd. United Drug House Dublin IRELAND

2000 Galloping Hill Road Kenilworth NJ 07033

2000 Galloping Hill Rd. Kenilworth NJ 07033

Gilead Sciences, Inc. 333 Lakeside Drive Foster city CA 94404

ErgoNex Pharma GmbH Ruetistr. 20 CH-9050 Appenzell SWITZERLAND

Cambridge MA 02138

67 Winston Churchill Avenue

Schering-Plough Research Institute

Schering-Plough Research Institute

Biomeasure, Inc. 27 Maple St. Milford MA 01757-3650

Ferring Laboratories, Inc. Suffern NY 10901

Orphan Therapeutics, LLC 3 Werner Way

Genta, Inc. 200 Connell Drive Berkley Heights NJ 07922

Genta Inc. 200 Connell Drive

Watson Laboratories Research Park 417 Wakara Way

Star Pharmaceuticals, Inc. 1990 N.W. 44th Street

Bio-Technology General Corp. 70 Wood Avenue South Iselin NJ 08830

Prestwick Pharmaceuticals, Inc. 1825 K Street, NW Suite 1475

Danforth, Jr., MD, Elliot University of Vermont 84 Beartown Rd.

Sanofi-Aventis Pharma 9 Great valley Parkway Malvern PA 19355-1304

Antisense Pharma GmbH Josef-Engert-Str. 9 93053 Regensberg GERMANY

Kuros Biosurgery AG Technoiparkstrasse 1 Zurich SWITZERLAND

Celgene Corporation 86 Morris Avenue Summit NJ 07901

400 Rella Boulevard, Suite 201

Round Valley Executive Center

Lebanon NJ 08833

Berkeley Heights NJ 07922

Salt Lake City UT 84108

Pompano Beach FL 33064

Washington DC 20006

Underhill VT 05489

Andrulis Research Corporation Beltsville MD 20705

Celgene Corporation P.O. Box 4914 7 Powder Horn Drive

Celgene Corporation 7 Powder Horn Dr. Warren NJ 07059

Pediatric Pharmaceuticals, Inc. 718 Bradford Avenue Westfield NJ 07090

Pediatric Pharmaceuticals, Inc. 718 Bradford Avenue Westfield NJ 07090

Pediatric Pharmaceuticals, Inc. 718 Bradford Avenue Westfield NJ 07090

Celgene Corporation P.O. Box 4914 7 Powder Horn Drive

Andrulis Research Corporation Beltsville MD 20705

Andrulis Research Corporation Beltsville MD 20705

Celgene Corporation 7 Powder Horn Dr. Warren NJ 07059

Celgene Corporation P.O. Box 4914 7 Powder Horn Srive

Celgene Corporation 7 Powder Horn Dr. Warren NJ 07059

Adienne S.r.l. Bergamo ITALY

SciClone Pharmaceuticals, Inc. 901 Mariner's Island Blvd San Mateo CA 94404

11800 Baltimore Avenue, Suite 113

Warren NJ 07059

Warren NJ 07059

11800 Baltimore Avenue, Suite 113

11800 Baltimore Avenue, Suite 113

Warren NJ 07059

24128 Bergamo, 64/B Broseta Street

SciClone Pharmaceuticals, Inc. 950 Tower Lane Suite 900

SciClone Pharmaceuticals, Inc. 901 Mariner's Island Blvd.

SciClone Pharmaceuticals, Inc.

3 Bethesda Metro Center Suite 700

Iolab Pharmaceuticals 500 Iolab Drive Claremont CA 91711

Sanofi-Synthelabo, Inc. 9 Great Valley Parkway PO Box 3026

3300 Hyland Avenue Costa Mesa CA 92626

Arginox Pharmceuticals, Inc. 120 Constitution Drive Menlo Park CA 94025

Miravant Medical Technologies 336 Bollay Drive Goleta CA 93117

P. O. Box 368 900 Ridgebury Road

920 U.S. Highway 202 Raritan NJ 08869

Sanofi-Aventis US, Inc. 11 Great Valley Parkway P. O. Box 3026

Laphal Laboratoires 75116 Paris FRANCE

Aastrom Biosciences, Inc. Domino's Farms

Foster City CA 94404-2125

San Mateo CA 94404-1593

901 Mariner's Blvd., Suite 205

San Mateo CA 94404-1593

RegeneRx Biopharmaceuticals, Inc.

Bethesda MD 20814

Malvern PA 19355

Valeant Research & Development

Boehringer Ingelheim Pharmaceuticals, Inc.

Ridgefield CT 06877 Johnson & Johnson

Pharmaceutical Research & Dev.

Malvern PA 19355

48 Bis, Rue des Belles-Feuilles

24 Frank Lloyd Wright Drive

Ann Arbor MI 48105

Aastrom Biosciences, Inc. Domino's Farms, Lobby L Ann Arbor MI 48105

Orfagen FRANCE

Athena Neurosciences, Inc. 800 Gateway Boulevard

Novartis Pharmaceuticals Corp. Drug Regulatory Affairs One Health Plaza

Axentis Pharma AG 138 Limmatquai CH-8001 Zurich SWITZERLAND

Sterling Winthrop 9 Great Valley Parkway Malvern PA 19355

Biogen IDEC Inc. 3030 Callan Road San Diego CA 92121

Orion Corporation P.O. Box 65 02101 Espoo FINLAND

Chroma Therapeutics Ltd. 93 Milton Park Oxfordshire OX14 4RY UNITED KINGDOM

920 US Highway 202 P. O. Box 300

920 U S Highway 202 Raritan NJ 08869

TheraQuest Biosciences, LLC 146 Medinah Drive Blue Bell PA 19422-3212

TheraQuest Biosciences, LLC 146 Medinah Drive Blue Bell PA 19422-3212

Pharmacia Inc. P.O. Box 16529 Columbus OH 43216

Parc Technologique Du Canal-4

31521 Ramonville Saint Agne

South San Francisco CA 94080

East Hanover NJ 07936-1080

Johnson & Johnson Pharmaceutical Research & Dev.

Raritan NJ 08869

Ortho Biotech Oncology Research & Development

Pharmacia Inc. P.O. Box 16529 Columbus OH 43216

AUSTRALIA

Celtrix Pharmaceuticals, Inc. 3055 Patrick Henry Drive Santa Clara CA 95054

Roslin, Edinburgh EH259PP Scotland UNITED KINGDOM

Genentech, Inc. 1 DNA Way

Medac GmbH Fehlandtstrasse 3 D-20354 Hamburg GERMANY

Antigenics, Inc. 3 Forbes Road Lexington MA 02421

Antigenics, Inc. 3 Forbes Road Lexington MA 02421

34 Sherrill Rd. Marshfield MA 02050

Cell Works Inc. 6200 Seaforth Street Baltimore MD 21224-6506

VioQuest Pharmaceuticals, Inc. 180 Mt. Airy Road Basking Ridge NJ 07920

Baylor Research Institute 3330 Live Oak Blvd Dallas TX 75204

Baylor Research Institute 3812 Elm Street

Medimmune Oncology, Inc. One MedImmune Way Gaithersburg MD 20878

Medimmune Oncology, Inc. One MedImmune Way Gaithersburg MD 20878

Medimmune Oncology, Inc. One MedImmune Way Gaithersburg MD 20878

Medimmune Oncology, Inc. One MedImmune Way Gaithersburg MD 20878

Angiogen Pharmaceuticals, Pty. Ltd.

Level 31, ABN AMRO Tower

88 Phillip Street Sydney, N.S.W. 2000

PPL Therapeutics (Scotland) Limited

South San Francisco CA 94080-4990

Hannan Ophthalmic Marketing Services, Inc

Institute of Metabolic Disease

Dallas TX 75226

Medimmune Oncology, Inc. One MedImmune Way Gaithersburg MD 20878

Debio R.A. Inc. Mclean VA 22102

Chembiomed, Ltd. P.O. Box 8050, Station F Edmonton, Alberta CANADA

Chembiomed, Ltd. P.O. Box 8050 Edmonton, Alberta CANADA

Chembiomed, Ltd. P.O. Box 8050 Edmonton, Alberta CANADA

Chembiomed, Ltd. P.O. Box 8050 Edmonton, Alberta CANADA

Hemotec Medical Products, Inc. Box 19255 Johnston RI 02919

CustomCare Pharmacy 5710 Hoover Blvd Tampa FL 33634

Structural GenomiX, Inc. (SGX) 10505 Roselle Street San Diego CA 92121

EMD Serono, Inc. One Technology Place Rockland MA 02370

EMD Serono, Inc. One Technology Place Rockland MA 02370

Kennedy & Hoidal, M.D.'s

arGentis Pharmaceuticals, LLC 20 South Dudley Street Memphis TN 38139

AB Science 3, avenue GeorgeV 75008 Paris FRANCE

30 New York Avenue P. O. Box 331

7929 Westpark Drive, Suite 400

University of Utah Health Sciences Center

50 North Medical Drive, Room 4R240

Salt Lake City UT 84132-0001

Gel-Tec, Division of Tishcon Corp

Westbury NY 11590

30 New York Avenue P.O. Box 331

30 New York Ave. PO Box 331

Wilex Biotechnology GmbH Grillparzerstrasse 10B 81675 Munich GERMANY

Vitreo Retinal Techologies, Inc 2 Venture Plaza Irvine CA 92618

Inspire Pharmaceuticals, Inc. Durham NC 27703

Inspire Pharmaceuticals, Inc. Durham NC 27703

EMD Serono, Inc. One Technology Place Rockland MA 02370

Chiron Vision 500 Iolab Drive Claremont CA 91711

5200 Maryland Way Brentwood TN 37027

59 Route 10

Leas Research Products 78 Fallon Drive North Haven CT 06473

Gel-Tec, Division of TISHCON Corporation

Westbury NY 11590

Gel-Tec, Division of Tishcon Corp.

Westbury NY 11590

4222 Emperor Boulevard, Suite 470

4222 Emperor Boulevard, Suite 470

Asklepion Pharmaceuticals, LLC

Novartis Pharmaceuticals Corporation

East Hanover NJ 07936-1080

Verenta Pharmaceuticals, Inc. 10901 Granada Lane Suite 101

Neuropharm Ltd, Fetcham Park House Surrey KT22 9HD UNITED KINGDOM

Topo Target Germany AG Paul-Ehrlich Str. 42-44 GERMANY

AstraZeneca Pharmaceutical LP 1800 Concord Pike

H3 Pharma, Inc. Montreal, Quebec, CANADA

Debiovision, Inc. Suite 1400 CANADA

Debiopharm S.A. 17 rue des Terreaux CH-1000 Lausanne 9 SWITZERLAND

Debiopharm S.A. 17 rue des Terreaux CH-1000 Lausanne 9 SWITZERLAND

H3 Pharma, Inc. Montreal, Quebec

Anthera Pharmaceuticals, Inc. 25801 Industrial Blvd. Suite B

Cangene Corporation 155 Innovation Drive R3T 5Y3 CANADA

PhiloGene, Inc. 174 Summit Avenue Summit NJ 07901

mondoBIOTECH Europark Austrasse 79

4364 South Alston Avenue

Leawood KS 66211

D-60596 Frankfurt am Main

Wilmington DE 19830-8355

666 Sherbrooke Street West Suite 1400

666 Sherbrooke Street West

Montreal, Quebec H3A 1E7

666 Sherbrooke Street West, Suite 1400

Hayward CA 94545

Research Triangle Pharmaceuticals

200 Westpark Corporate Center

Durham NC 27713-2280

Immunomedics, Inc. 300 American Road Morris Plains NJ 07950

BioMarin Pharmaceutical Inc. 105 Digital Drive Novato CA 94949

Ovation Pharmaceuticals, Inc. Four Parkway North Deerfield IL 60015

Stuart Pharmaceuticals Division of ICI Americas Wilmington DE 19897

Stuart Pharmaceuticals Division of ICI Americas Wilmington DE 19897

Hana Biosciences, Inc. 7000 Shoreline Court

Hana Biosciences, Inc 7000 Shoreline Court Suite 370

ZOR Pharmaceuticals, LLC Suite 118

Meritage Pharma, Inc. 12481 High Bluff Drive Suite 160

Wellstat Therapeutics Corp. 930 Clopper Road Gaithersburg MD 20878

Merck Research Laboratories Merck & Co., Inc. P. O. Box 2000, RY 32-605

Merck & Co., Inc. Rahway NJ 07065-0900

VAXON-Biotech 3-5 impasse Reille FRANCE

Circe Biomedical, Inc. 99 Hayden Ave. Lexington MA 02421-7995

South San Francisco CA 94080

South San Francisco CA 94080

100-A Eastwood Center Drive

Wilmington NC 28403

San Diego CA 92130

Rahway NJ 07065-0900

P. O. Box 2000, RY 32-605

MAT Biopharma 4 rue Pierre Fontaine FRANCE

Immunomedics, Inc. 300 American Rd. Morris Plains NJ 07950

National Cancer Institute, DCT Bethesda MD 20892

Kanisa Pharmaceuticals, Inc. 12264 El Camino Real San Diego CA 02130

NIH, Executive Plaza North, Room 7-18