TwinLink™ cotton technology combines season-long Bt protection against worm pests with its powerful weed management technology. It contains two Bayer proprietary Bt genes that provide effective management of major lepidopteran pests, such as tobacco budworm, pink bollworm, cotton bollworm and cotton leafworm. TwinLink also confers full tolerance to Liberty® herbicide to control a wide range of broadleaf and grass weeds.

TwinLink will be available as a GlyTol® LibertyLink® TwinLink (GLT) trait package, which provides two Bt genes plus full tolerance to Liberty herbicide and glyphosate. This trait package is a powerful tool for high-level caterpillar control and offers two choices for over-the-top, broad-spectrum herbicide applications. GLT gives growers the flexibility to choose the herbicide applications that best fit their cotton-growing conditions and farm management practices. Growers have the ability to rotate herbicide modes of action to control weeds effectively and reduce the potential of weed resistance.

TwinLink produces two insecticidal Bt proteins, Cry1Ab and Cry2Ae, with independent actions for highly effective control of key leaf- and fruit-feeding lepidopteran pests. These novel Bt genes protect against a wide range of worm pests to help cotton growers maximize yield potential and fiber quality.

As with all Bt cottons, plant stress can sometimes affect the expression of Bt proteins. To maximize

the value of the TwinLink technology, it is best to manage your cotton to avoid significant periods of plant stress. Follow local guidelines for seeding rates, fertilization, seedling protection and other practices that promote good plant health.

New TwinLink™ TechnologyGives Cotton Growers the Power to Control Weeds and Pests Together

Bayer CropScience LP, 2 T.W. Alexander Drive, Research Triangle Park, NC 27709. Always read and follow label instructions. Bayer (reg’d), the Bayer Cross (reg’d), FiberMax®, GlyTol®, Liberty®, LibertyLink®, Stoneville®, Stoneville Design (reg’d), TwinLink™ and the Water Droplet Design (reg’d) are trademarks of Bayer. Liberty and TwinLink are not registered in all states. WideStrike is a registered trademark of Dow AgroSciences. Bollgard II is a registered trademark of Monsanto Technology LLC. For additional product information call toll-free 1-866-99-BAYER (1-866-992-2937) or visit our website at www.BayerCropScience.usCR0713TWNLNKA006V00R0

IMPORTANT: This bulletin is not intended to provide adequate information for use of these products. Read the label before using these products. Observe all label directions and precautions while using these products.

COTTON TRAIT LAUNCH PLAN*

+

+ +

+ +

2011

*Product launches are Bayer CropScience projections and are subject to regulatory approvals.** TwinLink™ contains built-in tolerance to Liberty® herbicide.

2012 2013 2014 2015 2016

next generationinsect resistance

+ +

COTTON TRAIT PIPeLINe ThROuGh 2016

TWINLINk FIeLd TRIAL ReseARCheR LOCATIONs

*Product launches are Bayer CropScience projections and are subject to regulatory approvals.**TwinLink contains built-in tolerance to Liberty herbicide.

Figure B Since 2008, more than 200 independent field trials have been conducted across U.S. cotton-growing regions measuring yield, weed control, insect damage and fiber quality. This map shows the researchers that have been involved in TwinLink testing.

The INNOvATIve TeChNOLOGIes keeP COMING

TwinLink technology is just the latest in a series of innovative weed and pest management solutions for cotton growers currently being developed by Bayer CropScience, the No. 1 provider of cottonseed to the global market. Bayer CropScience is committed to providing cotton growers with the diverse cotton products needed to plant the right variety on the right field.

Prior to planting TwinLink cotton seed, growers must read and sign the Bayer Grower Technology Agreement. Doing so confirms the reading of and compliance with the requirements and recommendations detailed in the current IRM Guide as well as the Trait and Technology Use Manual.

4

1

6 5

7

18

17

14

16

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21

9 8 12

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1920

10, 1122, 232, 3

1- Peter Ellsworth, Univ. of Ariz.2- Scott Akin, Univ. of Ark.3- Gus Lorenz, Univ. of Ark.4- R. Humphries, BCS, Shafter, Calif.5- Phillip Roberts, Univ. of Ga.,

Tifton, Ga.6- Ron Smith, Univ. of Ga.7- Lex Tyson, BCS, Albany, Ga.8- R. Leonard, LSU, Winnsboro, La.9- S. Miscinski, LSU, Shreveport, La.

10- Angus Catchot, Miss. St. Univ.11- Jeff Gore, Miss. St. Univ.12- Ryan Jackson, USDA13- D. Hughes, BCS14- J. Bacheler, N.C. State Univ.15- JR Bradley/VanDuyn/Rinehardt,

Chemtrol, Edenton, N.C.16- D. Reisig, N.C. State Univ.17- McCarty/Crooks, Carolina

Ag-Research18- Jeremy Greene, Clemson Univ.,

Elko, S.C.19- S. Baker, BCS, Memphis, Tenn.20- Scott Stewart, Univ. of Tenn.21- J. Adamczyk, USDA, Weslaco, Texas22- G. Henniger, BCS, Lubbock, Texas23- David Kerns, Texas A&M Univ.

GLyTOL LIbeRTyLINk TWINLINk† (GLT) COTTON TRAIT

* Confers a high level of protection from bollworms and a high level of glufosinate tolerance

** Confers only a moderate level of bollworm protection and moderate glufosinate tolerance

† It is anticipated that the first cotton varieties containing TwinLink will be available in the U.S. beginning in 2014, pending international import approvals.

= high-Level Protection = No Protection

= Moderate Protection = Not Labeled for use

Monsanto b2RF

bayer GLT* dow WRF**

Glyphosate Tolerance

Liberty herbicide Tolerance

bollworm Protection

All of the current Bt technologies, including TwinLink, work best when fields are free from weeds. Weeds can provide a food source for many of the lepidopteran pests that infest cotton and may allow small larvae to become bigger. Larger larvae are more tolerant to Bt proteins and may not be killed if they move onto the cotton crop.

Good weed control is another component of maximizing TwinLink value for insect control. Growers are advised to inquire with local authorities, such as their respective local Extension specialist, crop adviser or Bayer representative for cotton management recommendations specific for their area.

TwinLink cotton technology will be available to U.S. cotton growers in high-yielding, high-quality FiberMax® and Stoneville® cotton seed varieties beginning in the 2014 growing season, pending additional regulatory approvals in key import countries.

IRM ANd ReFuGe

Refuges are essential for Insect Resistance Management (IRM) of TwinLink. It is for this reason that the U.S. Environmental Protection Agency (EPA) mandates planting of refuge for TwinLink and other Bt cotton varieties. Refuges are a portion of the farming landscape that do not contain specific Bt genes and generate an abundance of susceptible target pests. Refuges provide a mechanism to delay the rate at

which resistance to Bt cotton increases in target pest populations, therein promoting the long-term effectiveness of the technology.

The EPA has approved TwinLink for use with its natural refuge option for much of the central and eastern Cotton Belt (see Figure A). Natural refuges consist of plants on which the target pests of TwinLink can develop, other than non-Bt cotton refuges planted by growers. Thus, natural refuges consist of both crop and non crop plants.

Natural refuge is not an option in pink bollworm-infested areas. Thus, structured or planted refuge is required in Arizona, California, New Mexico and the 15 counties in the El Paso/Trans-Pecos region of Texas (see Figure A). However, specific counties within these areas may have exemptions from this requirement by regulatory authorities, in accordance with state programs to eradicate pink bollworm. Growers are advised to inquire with local authorities, such as their respective State Departments of Agriculture, about whether such exemptions apply to the specific counties where they will plant TwinLink cotton.

Details on refuge requirements are available in the current Bayer CropScience Insect Resistance Management (IRM) Guide. The IRM program for TwinLink cotton is updated annually by Bayer based on feedback from grower and industry groups as well as input from Extension, research and regulatory experts.

Bollgard II TwinLink Non-Bt (100% boll damage)

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oll

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olls

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Gus Lorenz, University of Arkansas, 2011. This test site contained the heaviest sustained bollworm pressure of all test sites in 2011. Boll damage ratings showing the average damage on a weekly basis in August on each technology type (one non-Bt line, five TwinLink lines and two Bollgard II lines).

*Difference is not statistically significant between TwinLink and Bollgard II.

TWINLINk ANd bOLLGARd II vs. NON-Bt COTTON

Research conducted by Scott Stewart, University of Tennessee, 2011. Cumulative boll damage by plot.

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GL Variety A Non-Bt

11.5

TwinLink Variety A

13.5

TwinLink Variety B

12.8

Bollgard II Variety A

30

Bollgard II Variety B

AveRAGe WeekLy bOLL dAMAGe*

TWINLINk TesTING

Bayer CropScience has conducted extensive field research assessing the performance of TwinLink cotton varieties. Since 2008, more than 200 independent field trials have been conducted across U.S. cotton-growing regions measuring yield, weed control, insect damage and fiber quality (see Figure B on back page). This research has shown TwinLink technology provides:

• Broad-spectrum lepidopteran insect control comparable to Bollgard II®

• Complete control of tobacco budworm, pink bollworm and loopers

• Reduced bollworm damage through superior bollworm protection comparable to Bollgard II

• Significant reduction in damage caused by armyworms

• Greater efficiency and flexibility for weed and insect control that allows growers to make the right decisions for their farms

• GLT provides a wide application window for over-the-top applications of glyphosate or Liberty herbicide products

• Herbicide-tolerant traits with proven crop protection with no impact on yield or quality

hawaii

Figure ARefuge requirements and planting restrictions for TwinLink cotton. Producers should consult local authorities prior to planting to confirm requirements for specific fields or locations.

Structured refuge must be planted

Natural refuge

Planting prohibited

No state registration

sPeCTRuM OF ACTIvITy

Good Control suppression 0% Control

Cotton Leafworm Alabama argillacea

Cabbage Looper Trichoplusia ni

Soybean Looper Pseudoplusia includens

Tobacco Budworm Heliothis virescens

Pink Bollworm Pectinophora gossypiella

Cotton Bollworm Helicoverpa zea

American Bollworm Helicoverpa armigera

Yellowstriped Armyworm Spodoptera ornithogalli

Tropical Armyworm Spodoptera litura

Fall Armyworm Spodoptera frugiperda

Southern Armyworm Spodoptera eridania

Beet Armyworm Spodoptera exigua

Saltmarsh Caterpillar Estigmene acrea

Cotton Leaf Perforator Bucculatrix thurberiella

Cutworms Agrotis spp.

Beneficial Insects

Nontarget pests

PLANTING ResTRICTIONs ANd ReFuGe ReQuIReMeNTs FOR TWINLINk COTTON